EP1891201A4 - Pharmacokinetic-based culture system with biological barriers - Google Patents

Pharmacokinetic-based culture system with biological barriers

Info

Publication number
EP1891201A4
EP1891201A4 EP06813188A EP06813188A EP1891201A4 EP 1891201 A4 EP1891201 A4 EP 1891201A4 EP 06813188 A EP06813188 A EP 06813188A EP 06813188 A EP06813188 A EP 06813188A EP 1891201 A4 EP1891201 A4 EP 1891201A4
Authority
EP
European Patent Office
Prior art keywords
pharmacokinetic
culture system
biological barriers
based culture
barriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06813188A
Other languages
German (de)
French (fr)
Other versions
EP1891201A2 (en
Inventor
Gregory T Baxter
Robert Freedman
Andrew Harrison
Scott Meyers
Aaron Sin
Michael Shuler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Publication of EP1891201A2 publication Critical patent/EP1891201A2/en
Publication of EP1891201A4 publication Critical patent/EP1891201A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
EP06813188A 2005-05-18 2006-05-17 Pharmacokinetic-based culture system with biological barriers Withdrawn EP1891201A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68213105P 2005-05-18 2005-05-18
PCT/US2006/018951 WO2007021343A2 (en) 2005-05-18 2006-05-17 Pharmacokinetic-based culture system with biological barriers

Publications (2)

Publication Number Publication Date
EP1891201A2 EP1891201A2 (en) 2008-02-27
EP1891201A4 true EP1891201A4 (en) 2011-11-09

Family

ID=37758004

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06813188A Withdrawn EP1891201A4 (en) 2005-05-18 2006-05-17 Pharmacokinetic-based culture system with biological barriers

Country Status (5)

Country Link
EP (1) EP1891201A4 (en)
JP (1) JP2008539787A (en)
CN (1) CN101223268A (en)
CA (1) CA2607965A1 (en)
WO (1) WO2007021343A2 (en)

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US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2007081386A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2077912B1 (en) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009015390A2 (en) * 2007-07-26 2009-01-29 University Of Chicago Co-incuating confined microbial communities
EP2200931B1 (en) 2007-09-19 2017-06-07 The Charles Stark Draper Laboratory, Inc. Microfluidic structures with circular cross-section
CN101939644B (en) * 2008-01-10 2014-06-11 休雷尔公司 Immune system modeling devices and methods
WO2009149257A1 (en) 2008-06-04 2009-12-10 The University Of Chicago The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
DK2313487T3 (en) 2008-07-16 2018-06-18 Childrens Medical Center ORGANIZING DEVICE WITH MICRO-CHANNELS AND METHODS OF APPLICATION
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
KR101796906B1 (en) 2009-03-24 2017-11-10 유니버시티 오브 시카고 Method for carrying out a reaction
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
WO2011024592A1 (en) 2009-08-26 2011-03-03 国立大学法人東京大学 Method for culture of hepatocytes
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
EP2486409A1 (en) 2009-10-09 2012-08-15 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP3447155A1 (en) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwich assays in droplets
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
KR102117921B1 (en) * 2011-02-28 2020-06-03 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Cell culture system
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013086486A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
CN102643742B (en) * 2012-04-18 2013-06-05 西安建筑科技大学 Autotrophic bacteria kinetic parameter measurement device and method
US9528082B2 (en) 2012-07-25 2016-12-27 The Charles Stark Draper Laboratory, Inc. Modular platform for multi-tissue integrated cell culture
WO2014120772A1 (en) 2013-01-29 2014-08-07 The Charles Stark Draper Laboratory, Inc. Modular platform for multi-tissue integrated cell culture
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (en) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Method for detection of latent retrovirus
WO2016127009A1 (en) 2015-02-04 2016-08-11 The Charles Stark Draper Laboratory, Inc. Actuated valve or pump for microfluidic devices
NL2015130B1 (en) * 2015-07-09 2017-02-01 Mimetas B V Barrier function measurements.
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN105385598B (en) * 2015-11-30 2017-12-29 赵明光 Human cerebral arteriovenous malformations biomechanical model and its vitro construction method
CN105950461B (en) * 2016-07-20 2017-10-24 江苏瑞明生物科技有限公司 The unicellular accurate delivery system of nanometer
WO2018071354A1 (en) * 2016-10-14 2018-04-19 Wake Forest University Health Sciences Multi-organ "body on a chip" apparatus utilizing a common media
WO2018232096A1 (en) * 2017-06-14 2018-12-20 EMULATE, Inc. Effects of space travel on human brain cells
JP2020531038A (en) * 2017-08-31 2020-11-05 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム Cell culture plates, devices and methods for in vitro exposure

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US6001585A (en) * 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US20030082795A1 (en) * 2001-04-25 2003-05-01 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
WO2004018617A1 (en) * 2002-08-26 2004-03-04 Japan Science And Technology Agency Microchamber for nerve cell culture
WO2004018618A1 (en) * 2002-08-26 2004-03-04 Japan Science And Technology Agency Cell-cultivation microchamber with semipermeable membrane
US20040077075A1 (en) * 2002-05-01 2004-04-22 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
WO2005033263A1 (en) * 2003-10-01 2005-04-14 Athena Capital Partners, Llc Circulating flow device for assays of cell cultures, cellular components and cell products

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US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
JP3853195B2 (en) * 2001-10-29 2006-12-06 株式会社ルネサステクノロジ Semiconductor device
JP4607432B2 (en) * 2003-05-12 2011-01-05 高木産業株式会社 Cell or tissue culture device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001585A (en) * 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US20030082795A1 (en) * 2001-04-25 2003-05-01 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
US20040077075A1 (en) * 2002-05-01 2004-04-22 Massachusetts Institute Of Technology Microfermentors for rapid screening and analysis of biochemical processes
WO2004018617A1 (en) * 2002-08-26 2004-03-04 Japan Science And Technology Agency Microchamber for nerve cell culture
WO2004018618A1 (en) * 2002-08-26 2004-03-04 Japan Science And Technology Agency Cell-cultivation microchamber with semipermeable membrane
WO2005033263A1 (en) * 2003-10-01 2005-04-14 Athena Capital Partners, Llc Circulating flow device for assays of cell cultures, cellular components and cell products

Also Published As

Publication number Publication date
CA2607965A1 (en) 2007-02-22
EP1891201A2 (en) 2008-02-27
WO2007021343A3 (en) 2007-06-21
JP2008539787A (en) 2008-11-20
WO2007021343A2 (en) 2007-02-22
CN101223268A (en) 2008-07-16

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Effective date: 20111010

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Effective date: 20120508