EP2240470A4 - Improved and novel process for the preparation of bosentan - Google Patents
Improved and novel process for the preparation of bosentanInfo
- Publication number
- EP2240470A4 EP2240470A4 EP09705099A EP09705099A EP2240470A4 EP 2240470 A4 EP2240470 A4 EP 2240470A4 EP 09705099 A EP09705099 A EP 09705099A EP 09705099 A EP09705099 A EP 09705099A EP 2240470 A4 EP2240470 A4 EP 2240470A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- bosentan
- preparation
- improved
- novel process
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN103CH2008 | 2008-01-10 | ||
| IN2334CH2008 | 2008-09-24 | ||
| PCT/IN2009/000032 WO2009095933A2 (en) | 2008-01-10 | 2009-01-09 | Improved and novel process for the preparation of bosentan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2240470A2 EP2240470A2 (en) | 2010-10-20 |
| EP2240470A4 true EP2240470A4 (en) | 2012-05-23 |
Family
ID=40913375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP09705099A Withdrawn EP2240470A4 (en) | 2008-01-10 | 2009-01-09 | Improved and novel process for the preparation of bosentan |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP2240470A4 (en) |
| WO (1) | WO2009095933A2 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2222649A2 (en) | 2007-10-24 | 2010-09-01 | Generics (UK) Limited | Novel crystalline forms |
| EP2240469A2 (en) * | 2008-01-24 | 2010-10-20 | Actavis Group PTC EHF | Substantially pure and a stable crystalline form of bosentan |
| NZ587793A (en) | 2008-02-08 | 2012-06-29 | Generics Uk Ltd | Process for preparing bosentan |
| WO2010015623A1 (en) * | 2008-08-05 | 2010-02-11 | Farmaprojects, S. A. | Process for the preparation of endothelin receptor antagonists |
| WO2010032261A1 (en) * | 2008-08-12 | 2010-03-25 | Cadila Healthcare Limited | Process for preparation of bosentan |
| CN102272108A (en) * | 2008-11-03 | 2011-12-07 | 基因里克斯(英国)有限公司 | Hplc method for the analysis of bosentan and related substances and use of these substances as reference standards and markers |
| IT1393136B1 (en) | 2009-03-11 | 2012-04-11 | Sifa Vitor S R L | PROCEDURE FOR THE PREPARATION OF BOSENTAN |
| RU2011145813A (en) | 2009-04-13 | 2013-05-20 | Сандох Аг | METHOD FOR OBTAINING AN ENDOTHELIAL RECEPTOR ANTAGONIST (BOSENTAN) |
| WO2011021216A2 (en) * | 2009-08-10 | 2011-02-24 | Msn Laboratories Limited | Improved process for the preparation of 4-(1,1-dimethylethyl)-n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide |
| WO2011024056A2 (en) | 2009-08-27 | 2011-03-03 | Aurobindo Pharma Limited | An improved process for the preparation of bosentan |
| CA2781541A1 (en) * | 2009-11-12 | 2011-05-19 | Ranbaxy Laboratories Limited | Crystalline forms of bosentan salt and processes for their preparation |
| US9139537B2 (en) | 2010-08-11 | 2015-09-22 | Megafine Pharma(P) Ltd. | Process for preparation of bosentan |
| SI2621909T1 (en) * | 2010-10-01 | 2019-04-30 | Zach System S.P.A. | Process for preparing bosentan monohydrate and its intermediates |
| US20130245259A1 (en) | 2012-03-16 | 2013-09-19 | Natco Pharma Limited | Process for the preparation of bosentan monohydrate |
| WO2013186706A1 (en) * | 2012-06-12 | 2013-12-19 | Cadila Pharmaceuticals Ltd | Process for the preparation of bosentan |
| TR202018841A2 (en) * | 2020-11-23 | 2021-01-21 | Yilmaz Usta Duygu | FORMULATION OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFIED DRUG CARRIER SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292740A (en) * | 1991-06-13 | 1994-03-08 | Hoffmann-La Roche Inc. | Sulfonamides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW287160B (en) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| AU2001263850A1 (en) * | 2000-04-20 | 2001-11-07 | Actelion Pharmaceuticals Ltd | Pyrimidine-sulfonamides having endothelin-antagonist activity |
-
2009
- 2009-01-09 WO PCT/IN2009/000032 patent/WO2009095933A2/en active Application Filing
- 2009-01-09 EP EP09705099A patent/EP2240470A4/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5292740A (en) * | 1991-06-13 | 1994-03-08 | Hoffmann-La Roche Inc. | Sulfonamides |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009095933A2 (en) | 2009-08-06 |
| EP2240470A2 (en) | 2010-10-20 |
| WO2009095933A3 (en) | 2011-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2240470A4 (en) | Improved and novel process for the preparation of bosentan | |
| HK1141013A1 (en) | Process for the preparation of certain substituted sulfilimines | |
| ZA201202504B (en) | Process for the preparation of calcobutrol | |
| PL2151428T3 (en) | Process for the preparation of agomelatin | |
| SI2387566T1 (en) | Process for the preparation of rosuvastatin | |
| ZA200907191B (en) | Process for the preparation of gefitiib | |
| IL208792A0 (en) | Process for the preparation of amides | |
| HK1169396A1 (en) | Improved process for the preparation of ambrisentan and novel intermediates thereof | |
| PL390042A1 (en) | Process for the preparation of kvass | |
| SI2189442T1 (en) | Process and intermediates for the preparation of aliskiren | |
| EP2300467A4 (en) | Novel and improved processes for the preparation of paliperidone | |
| PT2151429E (en) | Process for the preparation of agomelatin | |
| IL243809A0 (en) | Process for the procuction of γ-ketosulfide compounds and γ-ketosulfide compounds | |
| EG26332A (en) | Process for the preparation of benzonorbornenes | |
| PL388931A1 (en) | Process for the preparation of fluorocarbfunctional silesquioxanes | |
| HU0700818D0 (en) | Process for the preparation of polyirocyanates of the diphenylmethone series | |
| IL208868A0 (en) | Processes for the preparation of amides | |
| IL211382A0 (en) | Process for the preparation of ethanedinitrile | |
| IL217460A0 (en) | Novel process for the preparation of 4-aminobut-2-enolides | |
| PL2462154T3 (en) | Novel crystal form of cdb-4124 and process for the preparation thereof | |
| IL213110A0 (en) | Process for the preparation of tetrazine derivatives | |
| GB0812613D0 (en) | Process for the preparation of 1-deoxyidonojirimycin | |
| EG27000A (en) | Process for the preparation of ibodutant (MEN15596) and related intermediates | |
| IL220160A (en) | Process for the preparation of defferasirox | |
| PL388933A1 (en) | Process for the preparation of fluorosilicones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20100810 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL BA RS |
|
| DAX | Request for extension of the european patent (deleted) | ||
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 401/04 20060101AFI20110706BHEP |
|
| TPAC | Observations filed by third parties |
Free format text: ORIGINAL CODE: EPIDOSNTIPA |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20120420 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 239/52 20060101ALI20120416BHEP Ipc: C07D 239/47 20060101AFI20120416BHEP |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20121120 |