EP2555689A1 - Bioabsorbable magnesium knots for securing surgical suture - Google Patents
Bioabsorbable magnesium knots for securing surgical sutureInfo
- Publication number
- EP2555689A1 EP2555689A1 EP11766292A EP11766292A EP2555689A1 EP 2555689 A1 EP2555689 A1 EP 2555689A1 EP 11766292 A EP11766292 A EP 11766292A EP 11766292 A EP11766292 A EP 11766292A EP 2555689 A1 EP2555689 A1 EP 2555689A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- knot
- suture
- magnesium
- absorbable
- knots
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 73
- 239000011777 magnesium Substances 0.000 title claims abstract description 73
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 72
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011701 zinc Substances 0.000 claims abstract description 8
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052751 metal Inorganic materials 0.000 claims description 15
- 239000002184 metal Substances 0.000 claims description 15
- 238000005336 cracking Methods 0.000 claims description 10
- 150000002739 metals Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 229910045601 alloy Inorganic materials 0.000 claims description 6
- 239000000956 alloy Substances 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 238000005275 alloying Methods 0.000 claims 6
- 238000001816 cooling Methods 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910000861 Mg alloy Inorganic materials 0.000 abstract description 17
- 238000002788 crimping Methods 0.000 abstract description 8
- 229910001297 Zn alloy Inorganic materials 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 20
- 206010052428 Wound Diseases 0.000 description 19
- 208000027418 Wounds and injury Diseases 0.000 description 19
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 15
- 239000000463 material Substances 0.000 description 15
- 239000010936 titanium Substances 0.000 description 15
- 229910052719 titanium Inorganic materials 0.000 description 15
- 230000035876 healing Effects 0.000 description 10
- 210000000988 bone and bone Anatomy 0.000 description 6
- 239000003356 suture material Substances 0.000 description 6
- 230000000399 orthopedic effect Effects 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 3
- 235000010210 aluminium Nutrition 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000003932 urinary bladder Anatomy 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 229910000521 B alloy Inorganic materials 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical class [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000002324 minimally invasive surgery Methods 0.000 description 2
- 238000012978 minimally invasive surgical procedure Methods 0.000 description 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 2
- 239000000622 polydioxanone Substances 0.000 description 2
- 239000004633 polyglycolic acid Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 229910001361 White metal Inorganic materials 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
- 238000002357 laparoscopic surgery Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 150000002680 magnesium Chemical class 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000002355 open surgical procedure Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 229910052761 rare earth metal Inorganic materials 0.000 description 1
- 150000002910 rare earth metals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 239000010969 white metal Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0467—Instruments for cutting sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00946—Material properties malleable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
- A61B2017/0488—Instruments for applying suture clamps, clips or locks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B2017/0496—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials for tensioning sutures
Definitions
- This invention relates generally to crimpable metal sleeves used to remotely secure sutures, and more particularly to such sleeves made from magnesium and its alloys.
- a surgeon's ability to hand tie a secure knot in a suture is severely compromised in many minimally invasive surgical procedures.
- absorbable sutures are preferred at remote tissue sites, it would be a significant advance to be able to readily create a strong, safe, low profile absorbable knot.
- laparoscopes video imaging equipment, trocar access ports, surgical insufflation and irrigation systems, graspers, scissors, cautery devices and suturing and stapling devices for wou nd closer have led to improved patient outcomes.
- Titanium Knot ® product is based on a surgical crimping technology that deforms a non-absorbable, malleable hollow titanium tube over suture strands to hold them together.
- the knots tested in this paper included the Suturelock ® , AN PA, San Mateo, California, mean tensile strength 1 4.7 N; Lapra-Ty* devices, Ethicon Endosurgery, Piscataway, New Jersey, 6.1 N; Hem-O-Lock clips, Week Closure Systems, Research Triangle Park, North Carolina, 5.4 N ; and an unspecified titanium clip, 3.0 N.
- the authors of this paper note that the hand tied knots "had substantially higher tensile strengths than any of the knot substitutes (P ⁇ 0.001 for all)" they tested. While the knots tested in the above study were less than half the strength of hand tied suture knots and below USP standards for minimal average knot strength, Titanium Knots ® tested under these conditions would have yielded knot strengths comparable to those of hand tied knots.
- bioabsorbable polymer such as a homopolymer, copolymer or a blend obtained from one or more monomers selected from the group consisting of glycolic acid, lactide, lactic acid p-dioxanne, E-caprolactone and trimethylene carbide.
- Lapra-Ty* clips can be made of absorbable polymers, but their bulkiness and inherent weakness raises questions regarding their efficacy in critical wound closure applications. To get the suture holding force strength minimally required by United States
- Heublein suggested employing various magnesium based vascular stents to temporarily hold a vessel open during healing (e.g. for opening coronary arteries).
- magnesium alloys for orthopedic structural implants and bio-absorbable stents have been previously reported by others to hold living tissue together (e.g., fractured bones) or apart (e.g., diseased arterial walls), to our knowledge, until now, no one has suggested the surgical use of magnesium alloys to hold non-native foreign materials (i.e., exogenous materials, not intrinsic to the body) like suture.
- non-native foreign materials i.e., exogenous materials, not intrinsic to the body
- our group is the first to describe the use of hollow magnesium components that are crimped together to hold suture materials.
- the use of hollow magnesium alloys to temporarily hold together exogenous materials is a new application not obvious to others over the past seven decades; until now, no one has suggested the use of magnesium for absorbable suture knots.
- an absorbable knot must be made of a material that has acceptable biocompatibility and excellent strength profiles over specific time periods. Magnesium is found throughout nature and is considered an essential component of the human body. The therapeutic potential of "Epsom salts" rich in magnesiu m have been recognized since the 1 7th century.
- Magnesium is an alkali earth metal from the second main group of the Periodic Table of Elements. This silvery white metal is the eighth most abundant element comprising 2.7% of the earth's crust and 0.1 3% of sea water. About 30 grams of magnesium is found in a healthy hu man, mostly in muscle and bone. The U.S. Government has recommended a regular daily adult allowance of magnesium intake of 420mg/day for males and 320mg/day for females.
- magnesium alloy mechanical properties can remain substantially strong enough to hold suture together long enough for many healing
- Magnesium has the highest strength to weight ratio of all structural metals. Magnesium is 36% lighter per unit volume than alu minum and 78% lighter than iron, both of which are not considered readily biocompatible. Magnesium (- 1 . 8 g/cm 3 ) is substantially less dense than titanium materials (4.5 - 4.7 g/cm 3 ). Magnesium based materials are available in a wide range of mechanical properties. Magnesium can be machined, cast, formed, welded, heat treated and annealed.
- AZ31 B A common example is AZ31 B-F magnesium alloy, where the last letter designates the "temper,” which here indicates “Fabricated,” contains 3% aluminum and 1 % zinc by weight and has a tensile strength of 260.0 MPa.
- Other preferred magnesium alloys incorporate small percentages of rare earth metals and or zirconium and yttriu m.
- the minimally invasive surgeon cannot simply hand tie knots in absorbable suture at remote sites as is easily achievable in open su rgery. While crimped, non-absorbable titanium sleeves have proved highly effective at securing suture together, they remain permanently within the patient.
- Bioabsorbable polymeric materials have not proved strong or durable enough for reliable, low profile, easy deployment for this application.
- the present invention is a novel development utilizing biocompatible, malleable, strong and absorbable alloys of magnesium to effectively place an automated remote suture knot that does not remain forever as a permanent foreign material at the suture site.
- a magnesium alloy knot made from AZ31 B alloy maintained the ability to hold suture together for a sufficient duration under simulated physiologic conditions.
- the Magnesium Knot was shaped like a hollow mushroom and weighed
- This embodiment of a Magnesium Knot has a wall thicknesses about 1 5% thicker than our current Titanium Knot ® .
- the hammer and anvil structures in the distal tip of the Titanium Knot ® crimper are modified to decrease the crimping depth and eliminate corners that concentrate stresses so that crimping between the hammer and anvil did not cause cracking of the
- the finished Magnesium Knots are rapidly heated in an argon gas environment to 650°F and maintained at that temperature for two hours. The Knots are then cooled gradually to room temperature over approximately four hours.
- knots were subsequently harvested at one, two and three week intervals post-op. Successful healing was demonstrated at gastric, urinary bladder and uterine tissue sites. Magnesium Knots, placed both from the inside and the outside of the urinary bladder, were also effective over this critical three week time interval in closing wounds in the bladder wall.
- FIG. 1 A is a perspective view of a Magnesium Knot within its delivery device over suture approaching a wound closure site.
- FIG. 1 B is a close-u p perspective view of a Magnesium Knot and suture now shown with its delivery device hidden.
- FIG. 2A is a cross-sectional view showing an un-crimped Magnesium Knot in the distal end of its delivery device positioned over suture upon apposed tissue edges.
- FIG. 2 B is a cross-sectional view of a crimped Magnesiu m Knot within the distal end of its delivery device still positioned upon opposed tissue edges, but now with suture tails cut.
- FIG. 3A shows a crimped Magnesiu m Knot immediately after release from its delivery device securing suture together to hold tissue wound edges in apposition.
- FIG. 3 B shows a Magnesium Knot and its suture partially absorbed during an early phase of wound healing.
- FIG. 3C shows the wound healing site at a later phase of wound healing after the Magnesium Knot and suture are no longer present.
- the Magnesium Knot 1 0 in accordance wi aspect of the present invention is shown in perspective view held within the distal tip of it delivery device 24, which also provides a suture exit hole 26.
- the relationship between a suture loop 1 2 and the Magnesium Knot 1 0 is illustrated to show the suture loop coursing and looping through both an apposing edge 1 4 of the left side of tissue wound segment 1 6 and a corresponding apposing edge 1 8 of the right side of tissue wound segment 20. Note that by advancing the
- FIG. 1 B shows a close-up of the Magnesium Knot 1 0 and suture 1 2, 22 of FIG. 1 A now with the tip of its delivery device 24 hidden to reveal the course of the suture as it passes through the Magnesium Knot 1 0 through the inside of its delivery device and out through the suture hole 26.
- one preferred magnesium alloy knot embodiment made from AZ31 B alloy, maintained the ability to hold suture together for a sufficient duration under simulated physiologic conditions.
- the Magnesium Knot was shaped like a hollow mushroom and weighed approximately 5.2 grams. While generally similar in shape to our current commercialized
- Titanium Knot ® this embodiment of a Magnesium Knot required wall thicknesses about 1 5% thicker than our current Titanium Knot ® .
- This embodiment also required the shapes of the hammer and anvil structures in the distal tip of the Titanium Knot ® crimper to be rounded and the depth of crimping reduced so that crimping between the hammer anvil did not cause cracking of the Magnesium Knot. It further required the development of a customized heat treating process to avoid cracking during crimping.
- the finished Magnesium Knots are rapidly heated in an argon gas environment to at least 600°F, preferably 650°F and maintained at that temperature for at least one hour, preferably two hours.
- the Knots are then cooled gradually to room temperature over approximately two hours, more preferably four hours.
- USDA Department of Agriculture
- the overall length of the Magnesium Knot 1 0 is preferably about 0.1 30 ⁇ 0.002 inches and the diameter of the mushroom cap or crown is 0.080 ⁇ 0.005 inches.
- the inside diameter of the elongated tubular portion is preferably about 0.035 ⁇ 0.005 inches and the outside diameter is approximately 0.0520 ⁇ 0.001 inches so that the wall thickness ranges from about 0.0078 to 0.0093 inches.
- the wall thickness will range from 0.002 to 0.01 9 inches. This is approximately 20% thicker than known knots and provides the characteristics described herein. While these dimensions have produced Knots that hold secu rely and do not crack, the dimensions may be changed as long as the secure holding and resistance to cracking are maintained.
- FIG. 2A and FIG. 2 B show in cross-section the pre-crimped
- the distal end of the delivery device consists of a tubular shaft tube 32 which is fixed to a structure providing an immobilized anvil 34 and deployable hammer 36.
- FIG. 2A shows mobile hammer 36 holding the un-crimped
- Magnesium Knot 1 0 between itself and fixed anvil 34. Wedge tip 38 with its attached suture blade 40 are in their most proximal position with the Magnesium Knot 1 0 adjacent to the wound closure site and with tension applied to the suture tails 22 (double arrows), so that the apposing wound edges 1 4 and 1 8 of tissue segments l 6 and 20 are held together.
- FIG. 2 B shows the now crimped Magnesium Knot 30 compressed between the fixed anvil 34 and the mobile hammer 36, which was driven down towards the fixed anvil 34 by the distal advancement of wedge tip 38, thereby compressing Magnesium Knot 30.
- the suture blade 40 which advances distally is attached to wedge tip 38 and transects the suture tails 22 above the crimped Magnesium Knot 30.
- the crimped Magnesium Knot 30 and its secured suture loop 1 2 are released from the delivery device, which is removed from the surgical site.
- the suture loop 1 2 is secured by the crimped Magnesium Knot 30 to hold together edges 1 4 and 1 8 from tissue segments 1 6 and 20.
- FIG. 3A, FIG. 3 B and FIG. 3C highlight the results of deploying a Magnesium Knot at a wound closure site upon acute deployment, at an
- FIG. 3A shows the crimped Magnesium Knot 30 and the free ends of suture loop 1 2 soon after deployment. Wound edges 1 4 and 1 8 are held together by the Magnesium Knot 30 and suture loop 1 2 to provide apposition for tissue segments 1 6 and 20.
- FIG. 3 B shows the same wound site of FIG. 3A, but now after the passage of time.
- the previously separate wound edges have begun to heal together re-establishing the intimate tissue plane 22 between tissue segments 1 6 and 20.
- the partially absorbed Magnesium Knot 50 shows an erosive loss of material along with material loss evident on the absorbing suture 52.
- FIG. 3C shows the same wound closure site as shown in FIG. 3A and FIG. 3 B now with all of the foreign magnesium alloy and suture material gone from the site of installation. At this stage, the tissue has remodeled so the previously separated wound edges become an almost indistinguishable healed zone 54.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/755,943 US8398680B2 (en) | 2010-04-07 | 2010-04-07 | Bioabsorbable magnesium knots for securing surgical suture |
PCT/US2011/021467 WO2011126588A1 (en) | 2010-04-07 | 2011-01-17 | Bioabsorbable magnesium knots for securing surgical suture |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2555689A1 true EP2555689A1 (en) | 2013-02-13 |
EP2555689A4 EP2555689A4 (en) | 2014-11-05 |
EP2555689B1 EP2555689B1 (en) | 2018-03-14 |
Family
ID=44761485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11766292.4A Active EP2555689B1 (en) | 2010-04-07 | 2011-01-17 | Bioabsorbable magnesium knots for securing surgical suture |
Country Status (3)
Country | Link |
---|---|
US (1) | US8398680B2 (en) |
EP (1) | EP2555689B1 (en) |
WO (1) | WO2011126588A1 (en) |
Cited By (1)
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US9585654B2 (en) | 2012-05-01 | 2017-03-07 | Dean & Webb, LLC | Segmentally rigid suture and suturing technique |
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US8617185B2 (en) * | 2007-02-13 | 2013-12-31 | P Tech, Llc. | Fixation device |
US8974476B2 (en) * | 2011-03-23 | 2015-03-10 | St. Jude Medical Puerto Rico Llc | Vascular closure device with compaction tube suture cutting port and methods |
US8968336B2 (en) | 2011-12-07 | 2015-03-03 | Edwards Lifesciences Corporation | Self-cinching surgical clips and delivery system |
US9078645B2 (en) | 2011-12-19 | 2015-07-14 | Edwards Lifesciences Corporation | Knotless suture anchoring devices and tools for implants |
US9078652B2 (en) | 2011-12-19 | 2015-07-14 | Edwards Lifesciences Corporation | Side-entry knotless suture anchoring clamps and deployment tools |
US9017347B2 (en) | 2011-12-22 | 2015-04-28 | Edwards Lifesciences Corporation | Suture clip deployment devices |
US8961594B2 (en) * | 2012-05-31 | 2015-02-24 | 4Tech Inc. | Heart valve repair system |
US10016193B2 (en) | 2013-11-18 | 2018-07-10 | Edwards Lifesciences Ag | Multiple-firing crimp device and methods for using and manufacturing same |
US9498202B2 (en) | 2012-07-10 | 2016-11-22 | Edwards Lifesciences Corporation | Suture securement devices |
AU2013345041B2 (en) | 2012-11-16 | 2018-08-02 | Brijjit Medical, Inc. | Fixation device for securing a linear element to a workpiece |
US20140276979A1 (en) * | 2013-03-15 | 2014-09-18 | Lsi Solutions, Inc. | Method and devices for securing bidirectional suture loops using coaxial mechanical fasteners |
CN105073026B (en) | 2013-07-11 | 2018-02-02 | 爱德华兹生命科学公司 | Without knot suture anchor installation system |
US10022114B2 (en) | 2013-10-30 | 2018-07-17 | 4Tech Inc. | Percutaneous tether locking |
CA2903891C (en) | 2014-05-30 | 2021-01-19 | Manouchehr A. Miraki | Systems for securing sutures |
US10603027B2 (en) * | 2014-07-08 | 2020-03-31 | Lsi Solutions, Inc. | Crimping instrument with reduced dimension, continued compatibility, and tissue protection features |
US11103235B2 (en) | 2014-07-08 | 2021-08-31 | Lsi Solutions, Inc. | Rotation adapter and receiver for minimally invasive surgical devices |
US9667884B2 (en) * | 2014-09-05 | 2017-05-30 | Lsi Solutions, Inc. | System and method for evaluating surgical knot formation |
JP6471341B2 (en) | 2014-12-10 | 2019-02-20 | エドワーズ・ライフサイエンシス・アーゲー | Multi-shot fixing device, method for using a multi-shot fixing device, and method for manufacturing a multi-shot fixing device |
SG10201901425QA (en) | 2014-12-24 | 2019-03-28 | Edwards Lifesciences Corp | Suture clip deployment devices |
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WO2011126588A1 (en) | 2011-10-13 |
US20110251641A1 (en) | 2011-10-13 |
US8398680B2 (en) | 2013-03-19 |
EP2555689A4 (en) | 2014-11-05 |
EP2555689B1 (en) | 2018-03-14 |
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