US1948982A - Hypodermic syringe - Google Patents

Hypodermic syringe Download PDF

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Publication number
US1948982A
US1948982A US628790A US62879032A US1948982A US 1948982 A US1948982 A US 1948982A US 628790 A US628790 A US 628790A US 62879032 A US62879032 A US 62879032A US 1948982 A US1948982 A US 1948982A
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Prior art keywords
plunger
barrel
contact
syringe
annular
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US628790A
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Robert K Cutter
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Bayer Corp
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Cutter Laboratories Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513Piston constructions to improve sealing or sliding

Definitions

  • This invention relates to improvements in the construction of hypodermic syringes particularly designed for use in connection with the storage, transportation, preservation and application of biological and similar products which are stored, transported, preserved or dispensed in syringe containers.
  • Objects of the present invention are generally to improve and simplify the construction and operation of devices of the character described; to provide a syringe charged with the medicine to be injected and which may function as a storage container but not permit leakage of the medicine from the front to the rear of the plunger even when subjected to vibration such as occurs during transit; to provide an improved type of piston or plunger which will not permit leakage from the front to the back thereof; to provide an improved piston or plunger which will not jam when pushed forward to eject the medicine from the syringe; to provide a piston or plunger which will permit a greater tolerance between the outer surface thereof and the inner surface of the cylinder or barrel in which it is used; to provide a plunger which is adapted to'be constructed entirely of a resilient material such as rubber or the like; other objects being apparent from a reading of the appended description taken in connection with the accompanying drawing which illustrates the invention.
  • Fig. 1 is a central longitudinal section through the syringe; and
  • Fig. 2 is a perspective view of the plunger showing the operating handle attached thereto.
  • A indicates a cylinder or barrel which in this instance is preferably constructed of glass, although it may be made of any suitable material.
  • the discharge end of the cylinder is reduced in diameter to form a neck 2 in which is inserted a rubber sealing plug 3 and this is in turn designed to receive a hollow needle 4 through which the serum is discharged.
  • the opposite end of the cylinder or barrel is open and provided with a flange 5 and this is protected by means of an annular rubber ring 6 which functions as a finger grip.
  • a combination plunger and sealing plug generally indicated at B and for suitable attachment thereto I provide an operating handle 7.
  • the periphery of the head terminates in an annular flange or ring 10 which forms the contact member of the plunger, and the exterior surface 11 of this member forms a snug fit with relation to the inner surface of the barrel.
  • the head member 8 also carries a plug or filler member 12 and there is an annular groove or space 13 formed between said plug and contact ring 10 to permit free expansion and contraction thereof.
  • the annular groove 13 should be of subtsantially greater depth than the contacting surface 11, while the width of this groove may be sufficient to admit liquid so that a pressure will be exerted on the walls thereof when forward movement is imparted to the plunger during discharge of the medicine; while that part 10 comprised between the annular groove13 and the exterior surface 11 (taken on a cross section) should be of sufficient thickness to make and maintain a good contact with the inner surface of the barrel in order to prevent suificient yielding to permit passage of liquid from ahead of the plunger to points therebehind, such thickness being determined-with a consideration of the softness and flexibility and possibly other characteristics of the material of which the plunger is made.
  • the projection 14 serves only to reduce the residual syringe contents to a minimum and is here shaped to fit the syringe neck as close.- ly as possible- It will, of course, be modified in shape to fit the neck of any syringe and it can be entirely eliminated, if desired, in which case a depression or well is formed within the annular contact ring 10.
  • the plunger as a whole will preferably be constructed of soft rubber or a similar material and in actual operation it will be inserted in the open end of the barrel after the barrel has been sterilized.
  • the barrel is then filled with serum through the neck and the plug prevents escape, leakage, or contamination of the serum content.
  • Products such as diphtheria anti-toxin, tetanus anti-toxin, as well as many other products, may be sold and transported in, and served to the patient from, syringes comprising my new invention.
  • the plunger when the plunger is forced inwardly by means of the operating handle the plunger as a whole tends to slightly compress due to frictional resistance and this compressing action further assists in maintaining a snug engagement between the plunger and the barrel.
  • plunger mechanism illustrated in this instance is primarily intended for antitoxin syringes which are filled with a single charge and which are discarded after first use, it is obvious that the plunger may be employed in connection with permanent syringes and like devices.
  • shank or extension 9 may be provided with molded threads or the like so that it may be readily connected with a rod or any other plunger operating mechanism of suitable construction.
  • the annular ring 10 of the plunger is sufficiently resilient to expand by compression, friction and by the application of pressure, while due to its resiliency it may be contracted or forced inwardly when inserted into a barrel, while said part 10 is suiliciently strong to maintain a position against the inner surface of the barrel which will prevent rearward movement of the medicine therepast.
  • a plunger thus constructed permits a greater tolerance between the plunger and the inner surface of the barrel than is usually possible with ordinary plungers.
  • plunger structure accordingly, has several advantages, towit, it will function both as a plunger and as a sealing plug. Due to the tolerance permitted, it will fit a greater number of cylinders of varying size with less tendency to leakage or sticking.
  • the groove 13v have a depth which is substantially twice the length of the contact surface 11 with the inner wall of the barrel and that the sealing plug and plunger B be made entirely of soft flexible rubber, but these specific features are not necessarily limitations of my invention. It is to be noted that 'it is not essential nor even very important that the pressure exerted by the liquid on moving the plunger forward in the syringe should be the cause of contact between the surface 11 of the plunger head and the inside surface of the barrel; but what is from the syringe and to exert sufficient force The against the inside wall of the barrel to prevent leakage while the fluid in the syringe is being expelled therefrom or during jarring in transportation, and such thickness and strength will, of course, be dependent upon the resilience and other physical characteristics of the material of which the plunger'is made which is preferably rubber.
  • a combined container and syringe comprising a barrel and a soft, flexible, resilient, elastic member therewithin, said member having a rearward portion the periphery of which is substantially smaller than the inner periphery of said barrel to form a manipulating shank adapted to accommodate a manipulating handle, an annular outwardly flaring portion on the forward end of said shank having an outer periphery substantially smaller than the inner face of said barrel except where said portion engages therewith and an integral annular contact portion on the forward end of said flaring portion and extending forwardly therefrom, the outer periphery of said contact portion being normally slightly larger than the inner face of said barrel, both said annular portions being throughout of substantial thickness sufiicient to maintain a continuous contact between said contact portion and said barrel during shipment and storage and also to prevent curling back to maintain a continuous ring of contact between said contact portion and said barrel on pushing said member forwardly.
  • a combined container and syringe comprising a barrel and a soft, flexible, resilient, elastic member therewithin, said member having a forward portion, a rearward portion and an intermediate portion connecting said two first mentioned portions, the forward face of said forward portion having an annular groove therein extending through said forward portion and at least into said intermediate portion, the outer periphery of said rearward portion being substantially smaller than the interior of said barrel to form a manipulating shank, said forward portion being normally slightly larger than said interior to form a contact portion, said contact portion having a ring of contact with the interior of said barrel, the outer wall of said groove being at all points thereof a substantial distance away from said contact surface, said intermediate portion graduating in cross-section from that of said contact portion to that of said shank portion, all of said contact and intermediate portions being of a thickness sufficient to maintain said contact during shipment and storage and toprevent curling back to maintain said contact on pushing said member forwardly.

Description

R. K. CUTTER Feb. 27, 1934.
HYPODERMI C SYRINGE Original Filed July 21, 1930 IN V EN TOR.
BY (/W A TT Patented F eb. 27, 1934 UNITED STATES PATENT OFFICE The Cutter Laboratory, Berkeley, Calif., a corporation of California Continuation of application Serial No. 469,447,
July 21, 1930. This application August 15, 1932;
Serial No. 628,790
2 Claims.
This application is a continuation of my application Serial No. 469,447, filed July 21, 1930, for Hypodermic syringe.
This invention relates to improvements in the construction of hypodermic syringes particularly designed for use in connection with the storage, transportation, preservation and application of biological and similar products which are stored, transported, preserved or dispensed in syringe containers.
Objects of the present invention are generally to improve and simplify the construction and operation of devices of the character described; to provide a syringe charged with the medicine to be injected and which may function as a storage container but not permit leakage of the medicine from the front to the rear of the plunger even when subjected to vibration such as occurs during transit; to provide an improved type of piston or plunger which will not permit leakage from the front to the back thereof; to provide an improved piston or plunger which will not jam when pushed forward to eject the medicine from the syringe; to provide a piston or plunger which will permit a greater tolerance between the outer surface thereof and the inner surface of the cylinder or barrel in which it is used; to provide a plunger which is adapted to'be constructed entirely of a resilient material such as rubber or the like; other objects being apparent from a reading of the appended description taken in connection with the accompanying drawing which illustrates the invention. In such drawing- Fig. 1 is a central longitudinal section through the syringe; and
Fig. 2 is a perspective view of the plunger showing the operating handle attached thereto.
Referring to the drawing in detail and particularly Fig. 1, A indicates a cylinder or barrel which in this instance is preferably constructed of glass, although it may be made of any suitable material. The discharge end of the cylinder is reduced in diameter to form a neck 2 in which is inserted a rubber sealing plug 3 and this is in turn designed to receive a hollow needle 4 through which the serum is discharged.
The opposite end of the cylinder or barrel is open and provided with a flange 5 and this is protected by means of an annular rubber ring 6 which functions as a finger grip. Adapted to be inserted in the cylinder or barrel A is a combination plunger and sealing plug generally indicated at B and for suitable attachment thereto I provide an operating handle 7. The plunger con- ,sists of a head member 8, one end of which terminates in a shank-like extension 9 which is adapted to receive the operating handle. The periphery of the head terminates in an annular flange or ring 10 which forms the contact member of the plunger, and the exterior surface 11 of this member forms a snug fit with relation to the inner surface of the barrel. The head member 8 also carries a plug or filler member 12 and there is an annular groove or space 13 formed between said plug and contact ring 10 to permit free expansion and contraction thereof. The annular groove 13 should be of subtsantially greater depth than the contacting surface 11, while the width of this groove may be sufficient to admit liquid so that a pressure will be exerted on the walls thereof when forward movement is imparted to the plunger during discharge of the medicine; while that part 10 comprised between the annular groove13 and the exterior surface 11 (taken on a cross section) should be of sufficient thickness to make and maintain a good contact with the inner surface of the barrel in order to prevent suificient yielding to permit passage of liquid from ahead of the plunger to points therebehind, such thickness being determined-with a consideration of the softness and flexibility and possibly other characteristics of the material of which the plunger is made. This part between the annular groove 13 and the outer periphery is so made that it normally tends to have an outer periphery slightly greater than the inner periphery of the barrel. The projection 14 serves only to reduce the residual syringe contents to a minimum and is here shaped to fit the syringe neck as close.- ly as possible- It will, of course, be modified in shape to fit the neck of any syringe and it can be entirely eliminated, if desired, in which case a depression or well is formed within the annular contact ring 10.
The plunger as a whole will preferably be constructed of soft rubber or a similar material and in actual operation it will be inserted in the open end of the barrel after the barrel has been sterilized. The barrel is then filled with serum through the neck and the plug prevents escape, leakage, or contamination of the serum content. Products such as diphtheria anti-toxin, tetanus anti-toxin, as well as many other products, may be sold and transported in, and served to the patient from, syringes comprising my new invention. Some of these products are necessary for the saving of human life, but it often happens that a physician will carry necessary products for many miles to the patient only to find that on arrival a substantial part of the medicine has leaked beyond the plunger and has become dried and un-usable, and this is one of the disadvantages, and it is a very great one, which has in practical use been obviated by my invention. Now, when the syringe is to be employed, end pressure is applied to the operating handle and the plunger will then be forced inwardly and during such movement will discharge the serum through the hollow needle. During such inward movement pressure is applied to the liquid and, as this enters the annular groove 13 formed between the filler plug 12 and the contact ring 10, an outward pressure is exerted on the inner face of the contact ring, thus forcing the contact face '11 into snug engagement with the inner surface of the barrel and insuring complete discharge of the serum content.
Furthermore, when the plunger is forced inwardly by means of the operating handle the plunger as a whole tends to slightly compress due to frictional resistance and this compressing action further assists in maintaining a snug engagement between the plunger and the barrel.
While the plunger mechanism illustrated in this instance is primarily intended for antitoxin syringes which are filled with a single charge and which are discarded after first use, it is obvious that the plunger may be employed in connection with permanent syringes and like devices. In that case the shank or extension 9 may be provided with molded threads or the like so that it may be readily connected with a rod or any other plunger operating mechanism of suitable construction.
In actual practice, the annular ring 10 of the plunger is sufficiently resilient to expand by compression, friction and by the application of pressure, while due to its resiliency it may be contracted or forced inwardly when inserted into a barrel, while said part 10 is suiliciently strong to maintain a position against the inner surface of the barrel which will prevent rearward movement of the medicine therepast. A plunger thus constructed permits a greater tolerance between the plunger and the inner surface of the barrel than is usually possible with ordinary plungers. plunger structure, accordingly, has several advantages, towit, it will function both as a plunger and as a sealing plug. Due to the tolerance permitted, it will fit a greater number of cylinders of varying size with less tendency to leakage or sticking. It is contractable and it is also automatically expansible when pressure or friction is applied and, as it is constructed of rubber, it may be molded or otherwise formed. It will be observed that no matter where a cross section is taken on the head of my novel plunger, it will comprise space free from plunger material.
I prefer that the groove 13v have a depth which is substantially twice the length of the contact surface 11 with the inner wall of the barrel and that the sealing plug and plunger B be made entirely of soft flexible rubber, but these specific features are not necessarily limitations of my invention. It is to be noted that 'it is not essential nor even very important that the pressure exerted by the liquid on moving the plunger forward in the syringe should be the cause of contact between the surface 11 of the plunger head and the inside surface of the barrel; but what is from the syringe and to exert sufficient force The against the inside wall of the barrel to prevent leakage while the fluid in the syringe is being expelled therefrom or during jarring in transportation, and such thickness and strength will, of course, be dependent upon the resilience and other physical characteristics of the material of which the plunger'is made which is preferably rubber. This is important since a jar which might exert no pressure on the fluid, say a jar from the side, and which consequently would have little or no effect on keeping the annular contact surface 11 against the inside wall of the barrel, would tend to have quite the opposite effect, namely, to make a break or opening so that fluid could leak from the front to the back of the plunger.
While certain features of the present invention are more or less specifically described, I wish is understood that various changes may be resorted to within the scope of the appended claims; similarly, that the materials and finishes of the several parts employed may be such as the manufacturer may decide or varying conditions or uses may demand.
Having thus described my invention, what I claim and desire to secure by Letters Patent is:
l. A combined container and syringe comprising a barrel and a soft, flexible, resilient, elastic member therewithin, said member having a rearward portion the periphery of which is substantially smaller than the inner periphery of said barrel to form a manipulating shank adapted to accommodate a manipulating handle, an annular outwardly flaring portion on the forward end of said shank having an outer periphery substantially smaller than the inner face of said barrel except where said portion engages therewith and an integral annular contact portion on the forward end of said flaring portion and extending forwardly therefrom, the outer periphery of said contact portion being normally slightly larger than the inner face of said barrel, both said annular portions being throughout of substantial thickness sufiicient to maintain a continuous contact between said contact portion and said barrel during shipment and storage and also to prevent curling back to maintain a continuous ring of contact between said contact portion and said barrel on pushing said member forwardly.
2. A combined container and syringe comprising a barrel and a soft, flexible, resilient, elastic member therewithin, said member having a forward portion, a rearward portion and an intermediate portion connecting said two first mentioned portions, the forward face of said forward portion having an annular groove therein extending through said forward portion and at least into said intermediate portion, the outer periphery of said rearward portion being substantially smaller than the interior of said barrel to form a manipulating shank, said forward portion being normally slightly larger than said interior to form a contact portion, said contact portion having a ring of contact with the interior of said barrel, the outer wall of said groove being at all points thereof a substantial distance away from said contact surface, said intermediate portion graduating in cross-section from that of said contact portion to that of said shank portion, all of said contact and intermediate portions being of a thickness sufficient to maintain said contact during shipment and storage and toprevent curling back to maintain said contact on pushing said member forwardly.
ROBERT K. CUTTER.
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Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2473734A (en) * 1947-05-31 1949-06-21 Arthur E Smith Hypodermic syringe
US2473733A (en) * 1947-05-31 1949-06-21 Arthur E Smith Syringe
US2574964A (en) * 1949-06-24 1951-11-13 Eisenstark Julius Syringe
US2575425A (en) * 1948-10-15 1951-11-20 Harry W Nelson Plastic hypodermic syringe
US2707466A (en) * 1951-07-18 1955-05-03 Cook Waite Lab Inc Hypodermic syringe
US2798487A (en) * 1952-05-09 1957-07-09 Becton Dickinson Co Syringe assembly
US3150801A (en) * 1960-09-06 1964-09-29 Clark H Hamilton Syringe
US3200813A (en) * 1962-12-24 1965-08-17 George J Christakis Aspirating syringes
US3354882A (en) * 1964-10-26 1967-11-28 Pharmaseal Lab Hypodermic syringe
US4051850A (en) * 1975-11-21 1977-10-04 Tischlinger Edward A Disposable medicament injector
FR2365350A1 (en) * 1975-11-03 1978-04-21 Kendall & Co IMPROVEMENTS WITH HYPODERMIC SYRINGES
US4153056A (en) * 1977-06-16 1979-05-08 Jules Silver Syringe with removable length adjusting member
US4159713A (en) * 1977-06-02 1979-07-03 Becton, Dickinson And Company Blood gas syringe
US4215701A (en) * 1978-08-21 1980-08-05 Concord Laboratories, Inc. Elastomeric plunger tip for a syringe
US4354507A (en) * 1978-01-17 1982-10-19 Concord Laboratories Syringe
US4411275A (en) * 1981-11-02 1983-10-25 Concord Laboratories, Inc. Syringe
EP0321414A2 (en) * 1987-12-16 1989-06-21 Albert Chanson Self-protecting syringe
EP1180377A1 (en) * 2000-08-16 2002-02-20 Schering Aktiengesellschaft Syringe with piston
US20030035744A1 (en) * 2001-08-20 2003-02-20 Taiji Horita Injector assembly capable of preventing subsequent dripping, as well as plunger and seal member for the injector assembly
US20070287965A1 (en) * 2006-06-13 2007-12-13 Nordson Corporation Liquid dispensing syringe
US20080269687A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Adhesive Patch Systems and Methods
US20080269713A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Automated filling systems and methods
US20080264261A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20080269680A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US20080269681A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20080269682A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
EP2016962A1 (en) 2007-07-20 2009-01-21 VOCO GmbH Spray and method for metered release of material
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US9199030B2 (en) 2005-05-06 2015-12-01 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
USD750228S1 (en) 2007-06-12 2016-02-23 Nordson Corporation Piston for a liquid dispensing syringe
US10598283B2 (en) * 2015-03-24 2020-03-24 Dorothy Feibleman Extrusion seal devices and methods
US11148338B2 (en) 2015-03-24 2021-10-19 Dorothy Feibleman Devices, systems, and methods for extruding materials bearing millefiori-like patterns

Cited By (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2473734A (en) * 1947-05-31 1949-06-21 Arthur E Smith Hypodermic syringe
US2473733A (en) * 1947-05-31 1949-06-21 Arthur E Smith Syringe
US2575425A (en) * 1948-10-15 1951-11-20 Harry W Nelson Plastic hypodermic syringe
US2574964A (en) * 1949-06-24 1951-11-13 Eisenstark Julius Syringe
US2707466A (en) * 1951-07-18 1955-05-03 Cook Waite Lab Inc Hypodermic syringe
US2798487A (en) * 1952-05-09 1957-07-09 Becton Dickinson Co Syringe assembly
US3150801A (en) * 1960-09-06 1964-09-29 Clark H Hamilton Syringe
US3200813A (en) * 1962-12-24 1965-08-17 George J Christakis Aspirating syringes
US3354882A (en) * 1964-10-26 1967-11-28 Pharmaseal Lab Hypodermic syringe
FR2365350A1 (en) * 1975-11-03 1978-04-21 Kendall & Co IMPROVEMENTS WITH HYPODERMIC SYRINGES
US4051850A (en) * 1975-11-21 1977-10-04 Tischlinger Edward A Disposable medicament injector
US4159713A (en) * 1977-06-02 1979-07-03 Becton, Dickinson And Company Blood gas syringe
US4153056A (en) * 1977-06-16 1979-05-08 Jules Silver Syringe with removable length adjusting member
US4354507A (en) * 1978-01-17 1982-10-19 Concord Laboratories Syringe
US4372325A (en) * 1978-01-17 1983-02-08 Concord Laboratories, Inc. Method for taking a blood sample
US4215701A (en) * 1978-08-21 1980-08-05 Concord Laboratories, Inc. Elastomeric plunger tip for a syringe
US4411275A (en) * 1981-11-02 1983-10-25 Concord Laboratories, Inc. Syringe
EP0321414A3 (en) * 1987-12-16 1989-09-20 Albert Chanson Self-protecting syringe
EP0321414A2 (en) * 1987-12-16 1989-06-21 Albert Chanson Self-protecting syringe
EP1180377A1 (en) * 2000-08-16 2002-02-20 Schering Aktiengesellschaft Syringe with piston
WO2002013892A1 (en) * 2000-08-16 2002-02-21 Schering Aktiengesellschaft Plunger syringe
US20030035744A1 (en) * 2001-08-20 2003-02-20 Taiji Horita Injector assembly capable of preventing subsequent dripping, as well as plunger and seal member for the injector assembly
US6796217B2 (en) * 2001-08-20 2004-09-28 Taisei Kako Co., Inc. Injector assembly capable of preventing subsequent dripping, as well as plunger and seal member for the injector assembly
US9199030B2 (en) 2005-05-06 2015-12-01 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US20070287965A1 (en) * 2006-06-13 2007-12-13 Nordson Corporation Liquid dispensing syringe
US9958067B2 (en) * 2006-06-13 2018-05-01 Nordson Corporation Liquid dispensing syringe
US20080264261A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8597270B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Automated filling systems and methods
US20080269681A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US20080269682A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US10772796B2 (en) 2007-04-30 2020-09-15 Medtronic Minimed, Inc. Automated filling systems and methods
US20090198215A1 (en) * 2007-04-30 2009-08-06 Medtronic Minimed, Inc. Adhesive patch systems and methods
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US20110230834A1 (en) * 2007-04-30 2011-09-22 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8083716B2 (en) * 2007-04-30 2011-12-27 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8172929B2 (en) 2007-04-30 2012-05-08 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US20080269680A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US9089641B2 (en) 2007-04-30 2015-07-28 Medtronic Minimed, Inc. Automated filling systems and methods
US20080269713A1 (en) * 2007-04-30 2008-10-30 Medtronic Minimed, Inc. Automated filling systems and methods
US9205191B2 (en) 2007-04-30 2015-12-08 Medtronic Minimed, Inc. Automated filling systems and methods
US9980879B2 (en) 2007-04-30 2018-05-29 Medtronic Minimed, Inc. Automated filling systems and methods
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