US20010020177A1 - Method of blood pressure moderation - Google Patents

Method of blood pressure moderation Download PDF

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Publication number
US20010020177A1
US20010020177A1 US09/767,062 US76706201A US2001020177A1 US 20010020177 A1 US20010020177 A1 US 20010020177A1 US 76706201 A US76706201 A US 76706201A US 2001020177 A1 US2001020177 A1 US 2001020177A1
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United States
Prior art keywords
blood pressure
pericardium
acupuncture point
patient
stimulating
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Granted
Application number
US09/767,062
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US6393324B2 (en
Inventor
Gregory Gruzdowich
David Swenson
Thomas Grey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RELIEF BAND MEDICAL TECHNOLOGIES LLC
Abbott Laboratories
Original Assignee
Gruzdowich Gregory J.
Swenson David D.
Grey Thomas L.
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Application filed by Gruzdowich Gregory J., Swenson David D., Grey Thomas L. filed Critical Gruzdowich Gregory J.
Priority to US09/767,062 priority Critical patent/US6393324B2/en
Publication of US20010020177A1 publication Critical patent/US20010020177A1/en
Assigned to SEQUEL LIMITED PARTNERSHIP II reassignment SEQUEL LIMITED PARTNERSHIP II GRANT OF IP SECURITY INTEREST Assignors: WOODSIDE BIOMEDICAL, INC.
Priority to US10/150,570 priority patent/US6658298B2/en
Application granted granted Critical
Publication of US6393324B2 publication Critical patent/US6393324B2/en
Assigned to ABBOTT LABORATORIES reassignment ABBOTT LABORATORIES ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WOODSIDE BIOMEDICAL, INC.
Assigned to ABBOTT LABORATORIES reassignment ABBOTT LABORATORIES ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WOODSIDE BIOMEDICAL, INC.
Assigned to RELIEF BAND MEDICAL TECHNOLOGIES LLC reassignment RELIEF BAND MEDICAL TECHNOLOGIES LLC NUNC PRO TUNC ASSIGNMENT (SEE DOCUMENT FOR DETAILS). Assignors: WOODSIDE BIOMEDICAL, INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/907—Acupuncture

Definitions

  • This invention relates to moderation of blood pressure.
  • High blood pressure and low blood pressure are usually treated with drugs.
  • Several proposals have been made to treat blood pressure with electrical stimulus applied to the body.
  • Terry, et al Treating Refractory Hypertension By Nerve Stimulation, U.S. Pat. No. 5,707,400 (Jan. 13, 1998) proposes implantation of an electrical coil around the vagus nerve, which runs superficially through the neck, and stimulation of the vagus nerve to lower high blood pressure.
  • Zhu, Blood Pressure Depressor U.S. Pat. No. 5,891,181 (Apr. 6, 1999) proposes electrical stimulation of nerves in the ear lobe to lower blood pressure.
  • the device uses non-invasive nerve stimulation whereby electricity is passed through two electrodes to stimulate nerves located on the ventral side of the wrist (this anatomical position is sometimes referred to as the palmar side of the wrist).
  • the treatment provided by the device is sometimes referred to as electro-acupuncture, which is a form of acupuncture, and the ventral site of application is referred to in the acupuncture art as the P 6 point, pericardium 6 point, or master point of the pericardium meridian (sometimes referred to as the vascular meridian).
  • a primary object of the invention is to provide a non-chemical, non-invasive, painless and inexpensive method of alleviating nausea. It is also portable, self-contained and convenient to the patient. Electrical pulse repetition rate of approximately 70 pulses per second and a pulse width of 80 microseconds has been found to provide effective relief of nausea in a patient.
  • Our currently preferred electrical pulse pattern comprises about 350 microsecond pulse width at about 31 pulses per second at power levels of about 10-35 milli-amps peak pulse height. Thus a wide range of pulse patterns may be used in noninvasive nerve stimulation devices.
  • the method described below employs use of the device described in Bertolucci, Nausea Control Device, U.S. Pat. 4,981,146, Jan. 1, 1991, and similar devices for moderation of blood pressure in patients suffering from high or low blood pressure.
  • a patient desiring to moderate his or her blood pressure places a pair of electrodes on the inside (ventral side) of the wrist, and applying electrical stimulation to the wrist through these electrodes. This has the effect of moderating blood pressure in the patient, lowering high blood pressure and raising low blood pressure.
  • the electrodes, pulse generating circuitry, and power supply are most conveniently packaged in a wrist-watch like housing which is held to the wrist with a watch band or with adhesive on the device.
  • the technique accomplished by the device is referred to as electro-acupuncture or non-invasive nerve stimulation.
  • FIGURE illustrates placement of an electroacupuncture over the P 6 acupuncture point on the human wrist.
  • the electrodes are on the underside of the housing 6 , the required battery and control electronics are housed within the housing, and input mechanisms are located on the outer face of the housing.

Abstract

A method of controlling the blood pressure in a patient with high blood pressure or low blood pressure utilizing a non-invasive nerve stimulation device applied to the wrist.

Description

    RELATED PATENTS
  • This is a continuation of U.S. application Ser. No. 09/307,272 filed May 7, 1999, now U.S. Pat. No. [0001] 6,______,______.
    • FIELD OF THE INVENTION
  • This invention relates to moderation of blood pressure. [0002]
    • BACKGROUND OF THE INVENTION
  • High blood pressure and low blood pressure are usually treated with drugs. Several proposals have been made to treat blood pressure with electrical stimulus applied to the body. For example, Terry, et al, Treating Refractory Hypertension By Nerve Stimulation, U.S. Pat. No. 5,707,400 (Jan. 13, 1998) proposes implantation of an electrical coil around the vagus nerve, which runs superficially through the neck, and stimulation of the vagus nerve to lower high blood pressure. Zhu, Blood Pressure Depressor, U.S. Pat. No. 5,891,181 (Apr. 6, 1999) proposes electrical stimulation of nerves in the ear lobe to lower blood pressure. Pomeranz, et al, Electrotherapy Acupuncture Apparatus and Method, U.S. Pat. No. 4,566,064 (Dec. 3 1985) mentions blood pressure as an indication for electro-acupuncture, but does not mention any point of application. [0003]
  • Bertolucci, Nausea Control Device, U.S. Pat. 4,981,146, Jan. 1, 1991, describes a nausea control device in the form of a watch-like housing attachable to the human wrist by an adjustable attachment band. The device uses non-invasive nerve stimulation whereby electricity is passed through two electrodes to stimulate nerves located on the ventral side of the wrist (this anatomical position is sometimes referred to as the palmar side of the wrist). The treatment provided by the device is sometimes referred to as electro-acupuncture, which is a form of acupuncture, and the ventral site of application is referred to in the acupuncture art as the P[0004] 6 point, pericardium 6 point, or master point of the pericardium meridian (sometimes referred to as the vascular meridian). A primary object of the invention is to provide a non-chemical, non-invasive, painless and inexpensive method of alleviating nausea. It is also portable, self-contained and convenient to the patient. Electrical pulse repetition rate of approximately 70 pulses per second and a pulse width of 80 microseconds has been found to provide effective relief of nausea in a patient. Our currently preferred electrical pulse pattern comprises about 350 microsecond pulse width at about 31 pulses per second at power levels of about 10-35 milli-amps peak pulse height. Thus a wide range of pulse patterns may be used in noninvasive nerve stimulation devices.
  • Recently, we have discovered that the application of electrical stimulus to the wrist, on the ventral side of the wrist and near the P[0005] 6 acupuncture point, effectively moderates blood pressure.
    • SUMMARY
  • The method described below employs use of the device described in Bertolucci, Nausea Control Device, U.S. Pat. 4,981,146, Jan. 1, 1991, and similar devices for moderation of blood pressure in patients suffering from high or low blood pressure. A patient desiring to moderate his or her blood pressure places a pair of electrodes on the inside (ventral side) of the wrist, and applying electrical stimulation to the wrist through these electrodes. This has the effect of moderating blood pressure in the patient, lowering high blood pressure and raising low blood pressure. The electrodes, pulse generating circuitry, and power supply are most conveniently packaged in a wrist-watch like housing which is held to the wrist with a watch band or with adhesive on the device. The technique accomplished by the device is referred to as electro-acupuncture or non-invasive nerve stimulation. [0006]
    • DETAILED DESCRIPTION OF THE FIGURE
  • The FIGURE illustrates placement of an electroacupuncture over the P[0007] 6 acupuncture point on the human wrist.
    • DETAILED DESCRIPTION OF THE INVENTION
  • Our discovery derives from speculation regarding the potential biological effects of electrical stimulation of the P[0008] 6 acupuncture point beyond the suppression of nausea described in the Bertolucci patent. Volunteer patients were tested for blood pressure, with two blood pressure measurements taken about five minutes apart. All subjects had the ReliefBand® NST™ non-invasive nerve stimulation device placed on their left wrist, as shown in the FIGURE, for approximately thirty minutes. The ReliefBand® NST™ non-invasive nerve stimulation device 1 was secured with strap 2 to the ventral side of the wrist 3 such that the pair of electrodes 4 were disposed over the median nerve 5 (indicated by the phantom line) in contact with the skin in the vicinity of the P6 acupuncture point. The electrodes are on the underside of the housing 6, the required battery and control electronics are housed within the housing, and input mechanisms are located on the outer face of the housing. After thirty minutes of treatment, the blood pressure of each patient was measured twice (measurements were separated by five minutes interval). A statistically significant reduction in blood pressure was observed in the group. In some patients, blood pressure was lowered by as much as ten percent. One patient whose blood pressure was considered abnormally low was increased toward the normal range (systolic pressure of 100 mmHG was raised approximately 10%). Patients with normal blood pressure at the start of the test were not observed to have significant changes in their blood pressure after application of the stimulation.
  • The mechanism of action is not thoroughly understood. However, we expect that both high blood pressure and low blood pressure conditions should be moderated by application of the same electrical stimulation to the ventral side of the wrist (or the P[0009] 6 acupuncture point or the median nerve). The technique accomplished by the device is referred to as electro-acupuncture or non-invasive nerve stimulation, and has components of acupuncture effect and acupressure. While we used the ReliefBand® NST™ non-invasive nerve stimulation device, any suitable means of applying electrical stimulation to the median nerve should work to moderate blood pressure. Also, while we applied the electrical stimulation to the median nerve at its superficial route through the wrist, stimulation of the median nerve along its entire course should provide similar benefits.
  • While the preferred embodiments of the methods have been described in reference to the environment in which they were developed, they are merely illustrative of the principles of the inventions. Other embodiments and configurations may be devised without departing from the spirit of the inventions and the scope of the appended claims. [0010]

Claims (15)

We claim:
1. A method for moderating blood pressure in a patient comprising non-invasively stimulating the pericardium-6 acupuncture point.
2. The method of
claim 1
, wherein the non-invasively stimulating comprises non-invasively electrically stimulating.
3. A method of moderating blood pressure in a patient with abnormal blood pressure; said method comprising:
mounting a non-invasive stimulation device onto the pericardium-6 acupuncture point; and
stimulating the pericardium-6 acupuncture point.
4. The method of
claim 3
, wherein the stimulating comprises electrically stimulating.
5. A method of moderating blood pressure in a patient with abnormal blood pressure; said method comprising:
mounting a non-invasive stimulation device onto the pericardium-6 acupuncture point;
generating a stimulation signal; and
stimulating the pericardium-6 acupuncture point.
6. A method of moderating blood pressure in a patient comprising the steps of:
mounting at least one electrode onto the pericardium-6 acupuncture point;
generating a stimulation signal; and
delivering the stimulation signal to the at least one electrode to stimulate the pericardium-6 acupuncture point.
7. The method of
claim 6
, wherein the mounting step comprises:
providing a wristwatch-like housing carrying the at least one electrode and a circuit for generating the stimulation signal; and
providing securing means for mounting the at least one electrode near the pericardium-6 acupuncture point.
8. The method of
claim 6
, wherein said delivering step comprises delivering an intermittent stimulation signal.
9. The method of
claim 6
, wherein said delivering step comprises delivering a continuous stimulation signal.
10. A method for reducing the blood pressure in a patient with high blood pressure, said method comprising the steps of:
mounting a non-invasive stimulation device onto the pericardium-6 acupuncture point; and
stimulating the pericardium-6 acupuncture point.
11. A method for reducing the blood pressure in a patient with high blood pressure, said method comprising the steps of:
applying an electro-acupuncture device to the pericardium-6 acupuncture point; and
stimulating the pericardium-6 acupuncture point with the electro-acupuncture device.
12. A method for reducing the blood pressure in a patient with high blood pressure comprising the steps of:
mounting a non-invasive electrical stimulation device onto the pericardium-6 acupuncture point;
generating an electrical stimulation signal; and
delivering the electrical stimulation signal to the pericardium-6 acupuncture point.
13. A method for increasing the blood pressure in a patient with low blood pressure, said method comprising the steps of:
mounting a non-invasive stimulation device onto the pericardium-6 acupuncture point; and
stimulating the pericardium-6 acupuncture point.
14. A method for increasing the blood pressure in a patient with low blood pressure, said method comprising the steps of:
applying an electro-acupuncture device to the pericardium-6 acupuncture point; and
stimulating the pericardium-6 acupuncture point with the electro-acupuncture device.
15. A method for increasing the blood pressure in a patient with low blood pressure comprising the steps of:
mounting a non-invasive electrical stimulation device onto the pericardium-6 acupuncture point;
generating an electrical stimulation signal; and
delivering the electrical stimulation signal to the pericardium-6 acupuncture point.
US09/767,062 1999-05-07 2001-01-22 Method of blood pressure moderation Expired - Fee Related US6393324B2 (en)

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