US20020010505A1 - Multilayered metal stent - Google Patents
Multilayered metal stent Download PDFInfo
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- US20020010505A1 US20020010505A1 US09/961,935 US96193501A US2002010505A1 US 20020010505 A1 US20020010505 A1 US 20020010505A1 US 96193501 A US96193501 A US 96193501A US 2002010505 A1 US2002010505 A1 US 2002010505A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
- A61F2002/91541—Adjacent bands are arranged out of phase
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
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Definitions
- the present invention relates to stents for deploying within body lumens, and more particularly, to optimizing the radiopacity of such stents.
- Stents are tubular structures that are implanted inside bodily conduits, blood vessels or other body lumens to widen and/or to help keep such lumens open.
- stents are delivered into the body while in a compressed configuration, and are thereafter expanded to a final diameter once positioned at a target location within the lumen.
- Stents are often used following or substituting for balloon angioplasty to repair stenosis and to prevent future restenosis and, more generally, may be used in repairing any of a number of tubular body conduits such as those in the vascular, biliary, genitourinary, gastrointestinal, respiratory and other systems.
- Exemplary patents in the field of stents formed of wire for example, include U.S. Pat.
- stents For stents to be effective, it is essential that they be accurately positioned at a target location within a desired body lumen. This is especially true where, for example, multiple stenting is required with overlapping stents to cover excessively long regions or bifurcating vessels. In these and other cases, it is often necessary to visually observe the stent both during placement in the body and after expansion of the stent. Various approaches have been attempted to achieve such visualization. For example, stents have been made from radiopaque (i.e., not allowing the passage of x-rays, gamma rays, or other forms of radiant energy) metals, such as tantalum and platinum, to facilitate fluoroscopic techniques.
- radiopaque i.e., not allowing the passage of x-rays, gamma rays, or other forms of radiant energy
- Another technique that has been used to achieve the visualization of stents is the joining of radiopaque markers to stents at predetermined locations.
- the joining of the stent and marker materials e.g., stainless steel and gold, respectively
- the present invention provides stents of optimized radiopacity and mechanical properties.
- the present invention includes a stent comprising a tubular member which comprises struts of a first material, and a first coating on the tubular member.
- the first coating substantially covers the tubular member and is substantially uniform in thickness.
- the first coating comprises a second material that is more radiopaque than the first material comprising the struts.
- the stent further comprises a second coating disposed between the tubular member and the first coating, wherein the second coating covers only a portion of the tubular member.
- the portion where the second coating exists appears darker than where only the first coating exists.
- the stent is a coated bifurcated stent for positioning in a body lumen that is bifurcated into a trunk lumen and a branch lumen.
- the stent has trunk and branch legs for positioning in trunk and branch lumens, respectively.
- the stent is coated with multiple layers of radiopaque materials such when the stent is observed with fluoroscopy, the branch leg appears darker than the trunk leg.
- FIG. 1A illustrates a coated patterned stent, in accordance with an embodiment of the present invention.
- FIG. 1B is a cross-sectional view of a typical strut from the stent of FIG. 1A.
- FIG. 2A illustrates a preferred stent configuration in an embodiment of the present invention.
- FIG. 2B illustrates a most preferred configuration for a single stent cell, in accordance with an embodiment of the present invention.
- FIG. 3A illustrates a patterned stent having multiple coatings thereon, in accordance with an embodiment of the present invention.
- FIG. 3B is a cross-sectional view of a typical strut from the stent of FIG. 3A, at a location where two coatings have been applied to the stent.
- FIG. 3C is a cross-sectional view of a typical strut from the stent of FIG. 3A, at a location where only one coating has been applied to the stent.
- FIG. 4A illustrates a first coated bifurcated stent, in accordance with an embodiment of the present invention.
- FIGS. 4 B- 4 C illustrate a second coated bifurcated stent, in accordance with an embodiment of the present invention.
- the present invention provides optimal radiopacity of stents without sacrificing mechanical properties or performance.
- a stent according to the present invention is made from a base material having desired mechanical properties (e.g., strength) and coated with a material to provide optimal, radiopacity to the stent.
- the radiopacity of the stents of the present invention is optimized in the sense that, during fluoroscopic procedures, the stents are entirely visible but are not so radiopaque that angiographic details are masked.
- the present invention thus provides for stents that have both the desired mechanical properties of the base material and the desired radiopacity of the coating material.
- the stents of the present invention have the additional benefit of being manufactured according to simple and reproducible techniques.
- stent 100 is a tubular member 101 comprising struts 110 as shown in FIG. 1A- 1 B.
- strut is intended to mean any structural member of a stent, such as any radial, longitudinal, or other members made from wire, cut stock, or other materials.
- Struts 110 comprise a first material that is selected for its mechanical properties such as, for example, the ability to be delivered into the body while in a compressed configuration, the ability to expand or be expanded once positioned to a target location, the ability to resist recoil, and the ability to hold open a body lumen during the stent lifetime.
- Typical exemplary materials for struts 110 include stainless steel and nitinol.
- Stent 100 further comprises a first coating 102 of a second material that is selected for its radiopacity. Coating 102 covers the entire tubular member 101 with the result that intersections of the first and second materials are not exposed to the exterior of the stent. By not exposing intersections of the first and second materials to the exterior of the stent, the risks of creating a junction potential in the blood and causing the electrolytic corrosion of the stent are precluded.
- FIG. 1B shows a cross-sectional view of coating 102 on a typical strut 110 of stent 100 .
- both the strut 110 and coating 102 shows both the strut 110 and coating 102 to be substantially square in cross-sectional shape, the actual cross-sectional shape of either or both of these elements is any desired or suitable shape, such as circular, oval-shaped, rectangular, or any of a number of irregular shapes.
- Coating 102 is applied to tubular member 101 according to any suitable technique such as, for example, electroplating, electroless plating, ion beam aided deposition, physical vapor deposition, chemical vapor deposition, electron beam evaporation, hot-dipping or any other suitable sputtering or evaporation process.
- Coating 102 comprises any suitable radiopaque material such as, for example, gold, platinum, silver and tantalum.
- the thickness of coating 102 is an important aspect of the present invention. A coating that is too thick will result in a stent that is overly radiopaque, and angiographic details will consequently be masked during subsequent fluoroscopy. In addition, stent rigidity often increases with coating thickness, thus making it difficult to expand the stent for placement in a body lumen if the coating is too thick. On the other hand, a radiopaque coating that is too thin will not be adequately visible during fluoroscopy. Depending on the material and configuration of the tubular member 101 ; and the material of the coating 102 , the thickness of coating 102 is optimized to provide the optimum balance between radiopacity and strength.
- coating 102 be approximately 1-20%, and more preferably approximately 5-15%, of the underlying strut thickness. In all embodiments of the present invention, coating 102 is applied to the entire stent such that it is wholly visible during fluoroscopy. Accordingly, any suboptimal expansion at any position along the stent is visible and any deviations from perfect circular expansion can be noticed.
- stents of the present invention are of any suitable configuration, although the patterned configurations as described in WO 96 03092 and commonly-assigned, allowed U.S. Pat. application Ser. No. 08/457,354, filed May 31, 1995 and incorporated herein by reference, are preferred for all embodiments of the present invention.
- stent 100 is a tube having sides that are formed into a plurality of two orthogonal meander patterns intertwined with each other.
- the term “meander pattern” is used herein to describe a periodic pattern about a center line and “orthogonal meander patterns” are patterns having center lines that are orthogonal to each other.
- stent 100 optionally includes two meander patterns 11 and 12 .
- Meander pattern 11 is a vertical sinusoid having a vertical center line 9 .
- Meander pattern 11 has two loops 14 and 16 per period wherein loops 14 open to the right while loops 16 open to the left. Loops 14 and 16 share common members 15 and 17 , where member 15 connects from one loop 14 to its following loop 16 and member 17 connects from one loop 16 to its following loop 14 .
- Meander pattern 12 is a horizontal pattern having a horizontal center line 13 .
- Meander pattern 12 also has loops, labeled 18 and 20 , which may be oriented in the same or opposite directions. The stent configuration shown in FIG.
- FIG. 2A illustrates a detailed view of a single cell of the most preferred stent configuration of the present invention.
- stent 200 includes a second coating 202 applied between the struts 110 of stent 200 and first coating 102 .
- second coating 202 covers only a portion or multiple portions of stent 200 so that isolated regions of stent 200 are most visible during fluoroscopy.
- second coating 202 is applied to one or both of the proximate 111 and distal 112 ends of stent 100 , as shown in FIG. 3A.
- first coating 102 covers the entire stent 200 shown in FIGS. 3 A- 3 C.
- 3B and 3C show cross-sectional views of struts 110 of stent 100 where second coating 202 has and has not been applied, respectively.
- Such isolated marking is useful for the accurate positioning of the ends of stents, such as, for example, in the case of multiple stenting wherein the overlapping length is important, or, for example, in the case of ostial stenting wherein the position of the stent end relative to the ostium is important.
- Second coating 202 comprises a suitable radiopaque material such as gold, platinum, silver and tantalum, and may be the same or different material as first coating 102 .
- Second coating 202 is applied to stent 200 by any suitable technique, such as those described for the application of first coating 102 .
- Second coating 202 is applied only to a portion or multiple portions of tubular member 101 , for example, by masking during the application of second coating 202 or by isolated etching after second coating 202 is applied. It is to be appreciated that although coating 202 is herein described to be a “second” coating, it is applied to stent 200 before the application of first coating 102 .
- second coating 202 has a thickness that will result in increased radiopacity at the portion(s) where second coating 202 exists when compared with the portion(s) where second coating 202 does not exist. Because second coating 202 is applied to only a portion or multiple portions of stent 200 , it can be thickly applied without significantly affecting the resistance of stent 200 to expand or affecting the visibility of arterial details during fluoroscopy. Like first coating 102 , the thickness of second coating 202 is optimized to provide a desired balance between stent radiopacity and other properties. In general, however, second coating 202 is typically as thick or thicker than first coating 102 .
- first and second coatings 102 , 202 When both first and second coatings 102 , 202 are applied, it is generally preferred that the thickness of first and second coatings 102 , 202 are about 1-5% and 5-15%, respectively, of the underlying stent strut thickness. Furthermore, the combined thickness of first and second coatings 102 , 202 typically does not exceed 25% of the underlying stent strut thickness. As an illustrative example, second coating 202 is applied to a thickness of about 10 microns onto a stent having 100 micron diameter struts. First coating 102 is then applied to a thickness of about 1 micron.
- stent 300 is a bifurcated stent as shown in FIG. 4A.
- Stent 300 comprises a tubular member 301 that is bifurcated into tubular trunk and branch legs 310 , 311 for positioning in trunk and branch lumens of a bifurcated lumen, respectively.
- the entire stent is coated with first coating 102 as described for the embodiments shown in FIGS. 1 and 3.
- Branch leg 311 includes second coating 202 disposed between tubular member 301 and first coating 102 such that when stent 300 is observed with fluoroscopy, branch leg 311 appears darker than the trunk leg 310 .
- FIGS. 3B and 3C The cross-sectional views of the struts of stent 300 thus appear as shown in FIGS. 3B and 3C for branch and trunk legs 311 , 310 , respectively.
- Such a configuration is useful for aligning and inserting branch leg 311 into a branch lumen.
- branch leg 311 may be selectively inserted into branch aperture 312 of tubular member 301 so that tubular member 301 and trunk leg 310 are separately delivered into a bifurcated lumen.
- tubular member 301 is provided with a branch aperture 312 as shown in FIG. 4B.
- branch aperture 312 is aligned with the corresponding branch lumen.
- Tubular member portion 301 of stent 300 is thereafter expanded to secure its position in the lumen to be treated, and branch leg 311 is delivered through branch aperture 312 so that part of branch leg 311 is positioned into the branch lumen.
- Branch leg 311 is thereafter expanded as shown in FIG.
- a region 313 surrounding branch aperture 312 includes both first and second coatings 102 , 202 such that region 313 is most visible during fluoroscopy.
- the cross-sectional view of the struts 110 of stent 300 appear as shown in FIG. 3B for region 313 , and as shown in FIG. 3C elsewhere.
- Such a configuration is useful for aligning branch aperture 312 with a branch lumen so that branch leg 310 is thereafter easily inserted into the branch lumen.
Abstract
Coated stents for increased radiopacity. In one embodiment, the present invention includes a stent in the form of a tubular member comprising struts of a first material, and a first coating on the tubular member. The first coating substantially covers the tubular member and is substantially uniform in thickness. The first coating comprises a second material that is more radiopaque than the first material. In another embodiment, the stent further comprises a second coating between the tubular member and the first coating, wherein the second coating covers only a portion of the tubular member. In yet another embodiment, the stent is a coated bifurcated stent for positioning in a bifurcated body lumen.
Description
- The present invention relates to stents for deploying within body lumens, and more particularly, to optimizing the radiopacity of such stents.
- Stents are tubular structures that are implanted inside bodily conduits, blood vessels or other body lumens to widen and/or to help keep such lumens open. Typically, stents are delivered into the body while in a compressed configuration, and are thereafter expanded to a final diameter once positioned at a target location within the lumen. Stents are often used following or substituting for balloon angioplasty to repair stenosis and to prevent future restenosis and, more generally, may be used in repairing any of a number of tubular body conduits such as those in the vascular, biliary, genitourinary, gastrointestinal, respiratory and other systems. Exemplary patents in the field of stents formed of wire, for example, include U.S. Pat. Nos. 5,019,090 to Pichuk; 5,161,547 to Tower; 4,950,227 to Savin et al.; 5,314,472 to Fontaine; 4,886,062 and 4,969,458 to Wiktor; and 4,856,516 to Hillstead; each of which is incorporated herein by reference. Stents formed of cut stock metal, for example, are described in U.S. Pat. Nos. 4,733,665 to Palmaz; 4,762,128 to Rosenbluth; 5,102,417 to Palmaz and Schatz; 5,195,984 to Schatz; WO 91 FR013820 to Meadox; and WO 96 03092 to Medinol, each of which is incorporated herein by reference. Bifurcating stents are described in U.S. Pat. No. 4,994,071 to MacGregor, and commonly-assigned U.S. Pat. application Ser. No. 08/642,297, filed May 3, 1996, each of which is incorporated herein by reference.
- For stents to be effective, it is essential that they be accurately positioned at a target location within a desired body lumen. This is especially true where, for example, multiple stenting is required with overlapping stents to cover excessively long regions or bifurcating vessels. In these and other cases, it is often necessary to visually observe the stent both during placement in the body and after expansion of the stent. Various approaches have been attempted to achieve such visualization. For example, stents have been made from radiopaque (i.e., not allowing the passage of x-rays, gamma rays, or other forms of radiant energy) metals, such as tantalum and platinum, to facilitate fluoroscopic techniques. One of the potential problems with such stents, however, is that a useful balance of radiopacity and stent strength is difficult, if not impossible, to achieve. For example, in order to form such a stent of adequate strength, it is often necessary to increase stent dimensions such that the stent becomes overly radiopaque. Consequently, fluoroscopy of such a stent after deployment can hide the angiographic details of the vessel in which it is implanted, thus making it difficult to assess problems such as tissue prolapse and hyperplasia.
- Another technique that has been used to achieve the visualization of stents is the joining of radiopaque markers to stents at predetermined locations. The joining of the stent and marker materials (e.g., stainless steel and gold, respectively), however, can create a junction potential or turbulence in blood and thus promote thrombotic events, such as clotting. Consequently, the size of the markers is minimized to avoid this problem, with the adverse effect of greatly decreasing fluoroscopic visibility and rendering such visibility orientation-sensitive.
- Yet another technique that has been used to achieve the visualization of stents is to simply increase the thickness of such stents to thereby increase radiopacity. Overly thick stent struts, however, effectively create an obstruction to blood flow. In addition, design limitations for stents having thick struts often result in large gaps between these struts, thus decreasing the support of a surrounding lumen. Furthermore, overly thick stent struts could adversely affect stent flexibility.
- There is thus a need for the increased radiopacity of stents without sacrificing stent mechanical properties or performance. The coating of stents with radiopaque materials is described in U.S. Pat. No. 5,607,442 to Fishell et al. According to this patent, the disclosed radiopaque coating is much thicker on longitudinal stent members when compared with radial stent members such that only the longitudinal stent members are visible during fluoroscopy.
- The present invention provides stents of optimized radiopacity and mechanical properties.
- In one embodiment, the present invention includes a stent comprising a tubular member which comprises struts of a first material, and a first coating on the tubular member. The first coating substantially covers the tubular member and is substantially uniform in thickness. The first coating comprises a second material that is more radiopaque than the first material comprising the struts.
- In another embodiment of the present invention, the stent further comprises a second coating disposed between the tubular member and the first coating, wherein the second coating covers only a portion of the tubular member. When the stent is observed with fluoroscopy, the portion where the second coating exists appears darker than where only the first coating exists.
- In yet another embodiment of the present invention, the stent is a coated bifurcated stent for positioning in a body lumen that is bifurcated into a trunk lumen and a branch lumen. The stent has trunk and branch legs for positioning in trunk and branch lumens, respectively. In this embodiment, the stent is coated with multiple layers of radiopaque materials such when the stent is observed with fluoroscopy, the branch leg appears darker than the trunk leg.
- FIG. 1A illustrates a coated patterned stent, in accordance with an embodiment of the present invention.
- FIG. 1B is a cross-sectional view of a typical strut from the stent of FIG. 1A.
- FIG. 2A illustrates a preferred stent configuration in an embodiment of the present invention.
- FIG. 2B illustrates a most preferred configuration for a single stent cell, in accordance with an embodiment of the present invention.
- FIG. 3A illustrates a patterned stent having multiple coatings thereon, in accordance with an embodiment of the present invention.
- FIG. 3B is a cross-sectional view of a typical strut from the stent of FIG. 3A, at a location where two coatings have been applied to the stent.
- FIG. 3C is a cross-sectional view of a typical strut from the stent of FIG. 3A, at a location where only one coating has been applied to the stent.
- FIG. 4A illustrates a first coated bifurcated stent, in accordance with an embodiment of the present invention.
- FIGS.4B-4C illustrate a second coated bifurcated stent, in accordance with an embodiment of the present invention.
- The present invention provides optimal radiopacity of stents without sacrificing mechanical properties or performance. A stent according to the present invention is made from a base material having desired mechanical properties (e.g., strength) and coated with a material to provide optimal, radiopacity to the stent. The radiopacity of the stents of the present invention is optimized in the sense that, during fluoroscopic procedures, the stents are entirely visible but are not so radiopaque that angiographic details are masked. The present invention thus provides for stents that have both the desired mechanical properties of the base material and the desired radiopacity of the coating material. The stents of the present invention have the additional benefit of being manufactured according to simple and reproducible techniques.
- In one embodiment of the present invention,
stent 100 is atubular member 101 comprisingstruts 110 as shown in FIG. 1A-1B. The term “strut”, as used herein, is intended to mean any structural member of a stent, such as any radial, longitudinal, or other members made from wire, cut stock, or other materials.Struts 110 comprise a first material that is selected for its mechanical properties such as, for example, the ability to be delivered into the body while in a compressed configuration, the ability to expand or be expanded once positioned to a target location, the ability to resist recoil, and the ability to hold open a body lumen during the stent lifetime. Typical exemplary materials forstruts 110 include stainless steel and nitinol.Stent 100 further comprises afirst coating 102 of a second material that is selected for its radiopacity. Coating 102 covers the entiretubular member 101 with the result that intersections of the first and second materials are not exposed to the exterior of the stent. By not exposing intersections of the first and second materials to the exterior of the stent, the risks of creating a junction potential in the blood and causing the electrolytic corrosion of the stent are precluded. FIG. 1B shows a cross-sectional view ofcoating 102 on atypical strut 110 ofstent 100. Although FIG. 1B shows both thestrut 110 andcoating 102 to be substantially square in cross-sectional shape, the actual cross-sectional shape of either or both of these elements is any desired or suitable shape, such as circular, oval-shaped, rectangular, or any of a number of irregular shapes. -
Coating 102 is applied totubular member 101 according to any suitable technique such as, for example, electroplating, electroless plating, ion beam aided deposition, physical vapor deposition, chemical vapor deposition, electron beam evaporation, hot-dipping or any other suitable sputtering or evaporation process. Coating 102 comprises any suitable radiopaque material such as, for example, gold, platinum, silver and tantalum. - The thickness of
coating 102 is an important aspect of the present invention. A coating that is too thick will result in a stent that is overly radiopaque, and angiographic details will consequently be masked during subsequent fluoroscopy. In addition, stent rigidity often increases with coating thickness, thus making it difficult to expand the stent for placement in a body lumen if the coating is too thick. On the other hand, a radiopaque coating that is too thin will not be adequately visible during fluoroscopy. Depending on the material and configuration of thetubular member 101; and the material of thecoating 102, the thickness ofcoating 102 is optimized to provide the optimum balance between radiopacity and strength. In general, however, it is preferred thatcoating 102 be approximately 1-20%, and more preferably approximately 5-15%, of the underlying strut thickness. In all embodiments of the present invention, coating 102 is applied to the entire stent such that it is wholly visible during fluoroscopy. Accordingly, any suboptimal expansion at any position along the stent is visible and any deviations from perfect circular expansion can be noticed. - The stents of the present invention are of any suitable configuration, although the patterned configurations as described in WO 96 03092 and commonly-assigned, allowed U.S. Pat. application Ser. No. 08/457,354, filed May 31, 1995 and incorporated herein by reference, are preferred for all embodiments of the present invention. As an example of such a configuration (a closeup of which is shown in FIGS. 2A and 2B),
stent 100 is a tube having sides that are formed into a plurality of two orthogonal meander patterns intertwined with each other. The term “meander pattern” is used herein to describe a periodic pattern about a center line and “orthogonal meander patterns” are patterns having center lines that are orthogonal to each other. - As shown in FIG. 2A,
stent 100 optionally includes twomeander patterns 11 and 12. Meander pattern 11 is a vertical sinusoid having a vertical center line 9. Meander pattern 11 has twoloops loops 14 open to the right whileloops 16 open to the left.Loops common members member 15 connects from oneloop 14 to its followingloop 16 andmember 17 connects from oneloop 16 to its followingloop 14.Meander pattern 12 is a horizontal pattern having ahorizontal center line 13.Meander pattern 12 also has loops, labeled 18 and 20, which may be oriented in the same or opposite directions. The stent configuration shown in FIG. 2A, withorthogonal meander patterns 11 and 12, provides for a high degree of stent flexibility to facilitate expansion, yet results in a high degree of rigidity once the stent is expanded. FIG. 2B illustrates a detailed view of a single cell of the most preferred stent configuration of the present invention. - In another embodiment of the invention as shown in FIGS.3A-3C,
stent 200 includes asecond coating 202 applied between thestruts 110 ofstent 200 andfirst coating 102. In distinction tofirst coating 102, however,second coating 202 covers only a portion or multiple portions ofstent 200 so that isolated regions ofstent 200 are most visible during fluoroscopy. For example,second coating 202 is applied to one or both of the proximate 111 and distal 112 ends ofstent 100, as shown in FIG. 3A. As in the embodiment shown in FIGS. 1A-1B, however,first coating 102 covers theentire stent 200 shown in FIGS. 3A-3C. FIGS. 3B and 3C show cross-sectional views ofstruts 110 ofstent 100 wheresecond coating 202 has and has not been applied, respectively. Such isolated marking is useful for the accurate positioning of the ends of stents, such as, for example, in the case of multiple stenting wherein the overlapping length is important, or, for example, in the case of ostial stenting wherein the position of the stent end relative to the ostium is important. -
Second coating 202 comprises a suitable radiopaque material such as gold, platinum, silver and tantalum, and may be the same or different material asfirst coating 102.Second coating 202 is applied tostent 200 by any suitable technique, such as those described for the application offirst coating 102.Second coating 202 is applied only to a portion or multiple portions oftubular member 101, for example, by masking during the application ofsecond coating 202 or by isolated etching aftersecond coating 202 is applied. It is to be appreciated that althoughcoating 202 is herein described to be a “second” coating, it is applied tostent 200 before the application offirst coating 102. - When used,
second coating 202 has a thickness that will result in increased radiopacity at the portion(s) wheresecond coating 202 exists when compared with the portion(s) wheresecond coating 202 does not exist. Becausesecond coating 202 is applied to only a portion or multiple portions ofstent 200, it can be thickly applied without significantly affecting the resistance ofstent 200 to expand or affecting the visibility of arterial details during fluoroscopy. Likefirst coating 102, the thickness ofsecond coating 202 is optimized to provide a desired balance between stent radiopacity and other properties. In general, however,second coating 202 is typically as thick or thicker thanfirst coating 102. When both first andsecond coatings second coatings second coatings second coating 202 is applied to a thickness of about 10 microns onto a stent having 100 micron diameter struts.First coating 102 is then applied to a thickness of about 1 micron. - In another embodiment of the present invention,
stent 300 is a bifurcated stent as shown in FIG. 4A.Stent 300 comprises atubular member 301 that is bifurcated into tubular trunk andbranch legs first coating 102 as described for the embodiments shown in FIGS. 1 and 3.Branch leg 311, however, includessecond coating 202 disposed betweentubular member 301 andfirst coating 102 such that whenstent 300 is observed with fluoroscopy,branch leg 311 appears darker than thetrunk leg 310. The cross-sectional views of the struts ofstent 300 thus appear as shown in FIGS. 3B and 3C for branch andtrunk legs branch leg 311 into a branch lumen. - Alternatively,
branch leg 311 may be selectively inserted intobranch aperture 312 oftubular member 301 so thattubular member 301 andtrunk leg 310 are separately delivered into a bifurcated lumen. In this case,tubular member 301 is provided with abranch aperture 312 as shown in FIG. 4B. Whentubular member 301 is delivered to a bifurcated lumen,branch aperture 312 is aligned with the corresponding branch lumen.Tubular member portion 301 ofstent 300 is thereafter expanded to secure its position in the lumen to be treated, andbranch leg 311 is delivered throughbranch aperture 312 so that part ofbranch leg 311 is positioned into the branch lumen.Branch leg 311 is thereafter expanded as shown in FIG. 4C in an amount sufficient for its external surface to engage the portion of thetubular member 301 defining thebranch aperture 312 and secure thebranch leg 311 in the branch lumen andtubular member portion 301. In this embodiment of the invention, aregion 313 surroundingbranch aperture 312 includes both first andsecond coatings region 313 is most visible during fluoroscopy. In other words, the cross-sectional view of thestruts 110 ofstent 300 appear as shown in FIG. 3B forregion 313, and as shown in FIG. 3C elsewhere. Such a configuration is useful for aligningbranch aperture 312 with a branch lumen so thatbranch leg 310 is thereafter easily inserted into the branch lumen. - The present invention provides stents having optimal radiopacity without sacrificing stent properties or performance. Those with skill in the art may recognize various modifications to the embodiments of the invention described and illustrated herein. Such modifications are meant to be covered by the spirit and scope of the appended claims.
Claims (18)
1. A stent for deploying within a body lumen, said stent comprising:
a tubular member comprising struts which comprise a first material, said tubular member having a proximal end and a distal end and a longitudinal bore therethrough; and
a first coating on said tubular member, said first coating substantially covering said tubular member and being substantially uniform in thickness, said first coating comprising a second material;
wherein said second material is more radiopaque than said first material.
2. The stent of claim 1 , wherein the thickness of said first coating is approximately 1-20 percent of the thickness of an underlying strut.
3. The stent of claim 2 , wherein the thickness of the first coating is approximately 5-15 percent of the thickness of an underlying strut.
4. The stent of claim 1 , wherein said first coating is approximately 0.5-20 microns in thickness.
5. The stent of claim 1 , wherein said first material is selected from the group consisting of stainless steel and nitinol.
6. The stent of claim 1 , wherein said second material is selected from the group consisting of gold, platinum, silver and tantalum.
7. The stent of claim 1 , further comprising a second coating disposed between said tubular member and said first coating, said second coating covering only a portion of said tubular member.
8. The stent of claim 7 , wherein said second coating is located at said proximal or said distal end of said tubular member.
9. The stent of claim 7 , wherein when the stent is observed with fluoroscopy, said stent appears darker at the portion where said second coating exists than where said second coating does not exist.
10. The stent of claim 7 , wherein the thickness of said second coating is approximately 1-20 percent of the thickness of an underlying strut.
11. The stent of claim 10 , wherein the thickness of the second coating is approximately 5-15 percent of the thickness of an underlying strut.
12. The stent of claim 7 , wherein said second coating is approximately 0.5-20 microns in thickness.
13. The stent of claim 12 , wherein said second coating is approximately 5-15 microns in thickness.
14. The stent of claim 12 , wherein said first coating is approximately 1 micron in thickness.
15. The stent of claim 7 , wherein said second coating comprises a material selected from the group consisting of gold, platinum, silver and tantalum.
16. The stent of claim 1 , wherein said tubular member is bifurcated into a trunk leg and a branch leg for positioning in respective trunk and branch lumens of a bifurcated lumen.
17. The stent of claim 16 , further comprising a second coating between said tubular member and said first coating, said second coating covering only said branch leg.
18. The stent of claim 16 , wherein:
said tubular member includes a branch aperture;
said branch leg may be selectively disposed within said tubular member; and
a region of said tubular member adjacent to said branch aperture includes a second coating between said tubular member and said first coating.
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Cited By (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030093011A1 (en) * | 1998-06-17 | 2003-05-15 | Jalisi Marc Mehrzad | Performance enhancing coating on intraluminal devices |
WO2004103220A2 (en) * | 2003-05-15 | 2004-12-02 | Boston Scientific Limited | Medical devices and methods of making the same |
US20050131522A1 (en) * | 2003-12-10 | 2005-06-16 | Stinson Jonathan S. | Medical devices and methods of making the same |
US6926734B1 (en) * | 1996-05-29 | 2005-08-09 | Avantec Vascular Corporation | Radially expansible vessel scaffold having modified radiopacity |
US20050261760A1 (en) * | 2004-05-20 | 2005-11-24 | Jan Weber | Medical devices and methods of making the same |
US20050288768A1 (en) * | 2004-06-28 | 2005-12-29 | Krzysztof Sowinski | Two-stage stent-graft and method of delivering same |
US20060155370A1 (en) * | 2002-10-22 | 2006-07-13 | Medtronic Vascular, Inc. | Stent with intermittent coating |
US20060259126A1 (en) * | 2005-05-05 | 2006-11-16 | Jason Lenz | Medical devices and methods of making the same |
US20070038176A1 (en) * | 2005-07-05 | 2007-02-15 | Jan Weber | Medical devices with machined layers for controlled communications with underlying regions |
US20070156231A1 (en) * | 2006-01-05 | 2007-07-05 | Jan Weber | Bioerodible endoprostheses and methods of making the same |
WO2007094577A1 (en) * | 2006-02-15 | 2007-08-23 | Mal-Soo Jun | Bio artificial lacrimal canaliculus |
US20070224116A1 (en) * | 2006-03-27 | 2007-09-27 | Chandru Chandrasekaran | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
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US20070270942A1 (en) * | 2006-05-19 | 2007-11-22 | Medtronic Vascular, Inc. | Galvanic Corrosion Methods and Devices for Fixation of Stent Grafts |
US20080004691A1 (en) * | 2006-06-29 | 2008-01-03 | Boston Scientific Scimed, Inc. | Medical devices with selective coating |
US20080071350A1 (en) * | 2006-09-18 | 2008-03-20 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20080071357A1 (en) * | 2006-09-18 | 2008-03-20 | Girton Timothy S | Controlling biodegradation of a medical instrument |
US20080086195A1 (en) * | 2006-10-05 | 2008-04-10 | Boston Scientific Scimed, Inc. | Polymer-Free Coatings For Medical Devices Formed By Plasma Electrolytic Deposition |
US20080109072A1 (en) * | 2006-09-15 | 2008-05-08 | Boston Scientific Scimed, Inc. | Medical devices and methods of making the same |
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US20080130520A1 (en) * | 2005-06-09 | 2008-06-05 | Whirlpool Corporation | Network for communicating information related to a consumable to an appliance |
US20080140176A1 (en) * | 2006-10-18 | 2008-06-12 | Krause Arthur A | Medical stent and devices for localized treatment of disease |
US20080147177A1 (en) * | 2006-11-09 | 2008-06-19 | Torsten Scheuermann | Endoprosthesis with coatings |
US20080161906A1 (en) * | 2006-12-28 | 2008-07-03 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US20080183277A1 (en) * | 2006-09-15 | 2008-07-31 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US20080294246A1 (en) * | 2007-05-23 | 2008-11-27 | Boston Scientific Scimed, Inc. | Endoprosthesis with Select Ceramic Morphology |
US20080294236A1 (en) * | 2007-05-23 | 2008-11-27 | Boston Scientific Scimed, Inc. | Endoprosthesis with Select Ceramic and Polymer Coatings |
US20090018639A1 (en) * | 2007-07-11 | 2009-01-15 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090029077A1 (en) * | 2007-07-27 | 2009-01-29 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US20090035448A1 (en) * | 2007-07-31 | 2009-02-05 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
US20090076588A1 (en) * | 2007-09-13 | 2009-03-19 | Jan Weber | Endoprosthesis |
US20090118809A1 (en) * | 2007-11-02 | 2009-05-07 | Torsten Scheuermann | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
US20090118813A1 (en) * | 2007-11-02 | 2009-05-07 | Torsten Scheuermann | Nano-patterned implant surfaces |
US20090118822A1 (en) * | 2007-11-02 | 2009-05-07 | Holman Thomas J | Stent with embedded material |
US20090143855A1 (en) * | 2007-11-29 | 2009-06-04 | Boston Scientific Scimed, Inc. | Medical Device Including Drug-Loaded Fibers |
US20090281613A1 (en) * | 2008-05-09 | 2009-11-12 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20100004733A1 (en) * | 2008-07-02 | 2010-01-07 | Boston Scientific Scimed, Inc. | Implants Including Fractal Structures |
US20100008970A1 (en) * | 2007-12-14 | 2010-01-14 | Boston Scientific Scimed, Inc. | Drug-Eluting Endoprosthesis |
US20100030326A1 (en) * | 2008-07-30 | 2010-02-04 | Boston Scientific Scimed, Inc. | Bioerodible Endoprosthesis |
US20100087910A1 (en) * | 2008-10-03 | 2010-04-08 | Jan Weber | Medical implant |
US20100137978A1 (en) * | 2008-12-03 | 2010-06-03 | Boston Scientific Scimed, Inc. | Medical Implants Including Iridium Oxide |
US20100137977A1 (en) * | 2007-08-03 | 2010-06-03 | Boston Scientific Scimed, Inc. | Coating for Medical Device Having Increased Surface Area |
US20100222873A1 (en) * | 2009-03-02 | 2010-09-02 | Boston Scientific Scimed, Inc. | Self-Buffering Medical Implants |
US20100228341A1 (en) * | 2009-03-04 | 2010-09-09 | Boston Scientific Scimed, Inc. | Endoprostheses |
US20100233238A1 (en) * | 2006-03-24 | 2010-09-16 | Boston Scientific Scimed, Inc. | Medical Devices Having Nanoporous Coatings for Controlled Therapeutic Agent Delivery |
US20100272882A1 (en) * | 2009-04-24 | 2010-10-28 | Boston Scientific Scimed, Inc. | Endoprosthese |
US20100274352A1 (en) * | 2009-04-24 | 2010-10-28 | Boston Scientific Scrimed, Inc. | Endoprosthesis with Selective Drug Coatings |
US20100280612A1 (en) * | 2004-12-09 | 2010-11-04 | Boston Scientific Scimed, Inc. | Medical Devices Having Vapor Deposited Nanoporous Coatings For Controlled Therapeutic Agent Delivery |
US20100286763A1 (en) * | 1998-04-11 | 2010-11-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US20110022158A1 (en) * | 2009-07-22 | 2011-01-27 | Boston Scientific Scimed, Inc. | Bioerodible Medical Implants |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20110238151A1 (en) * | 2010-03-23 | 2011-09-29 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US8052743B2 (en) | 2006-08-02 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
US8057841B2 (en) | 2004-02-12 | 2011-11-15 | University Of Akron | Mechanically attached medical device coatings |
US8057534B2 (en) | 2006-09-15 | 2011-11-15 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
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US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
US8128689B2 (en) | 2006-09-15 | 2012-03-06 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8303643B2 (en) | 2001-06-27 | 2012-11-06 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US8353949B2 (en) | 2006-09-14 | 2013-01-15 | Boston Scientific Scimed, Inc. | Medical devices with drug-eluting coating |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
US8449603B2 (en) | 2008-06-18 | 2013-05-28 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
US8920491B2 (en) | 2008-04-22 | 2014-12-30 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
US8932346B2 (en) | 2008-04-24 | 2015-01-13 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
US9284409B2 (en) | 2007-07-19 | 2016-03-15 | Boston Scientific Scimed, Inc. | Endoprosthesis having a non-fouling surface |
US11547583B2 (en) * | 2016-09-09 | 2023-01-10 | Micro Medical Solutions, Inc. | Method and apparatus for treating critical limb ischemia |
Families Citing this family (162)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2192520A1 (en) | 1996-03-05 | 1997-09-05 | Ian M. Penn | Expandable stent and method for delivery of same |
EP1477133B9 (en) | 1996-03-05 | 2007-11-21 | Evysio Medical Devices Ulc | Expandable stent |
US6796997B1 (en) | 1996-03-05 | 2004-09-28 | Evysio Medical Devices Ulc | Expandable stent |
US6440165B1 (en) * | 1996-05-03 | 2002-08-27 | Medinol, Ltd. | Bifurcated stent with improved side branch aperture and method of making same |
US6770092B2 (en) | 1996-05-03 | 2004-08-03 | Medinol Ltd. | Method of delivering a bifurcated stent |
US7641685B2 (en) | 1996-05-03 | 2010-01-05 | Medinol Ltd. | System and method for delivering a bifurcated stent |
US7686846B2 (en) | 1996-06-06 | 2010-03-30 | Devax, Inc. | Bifurcation stent and method of positioning in a body lumen |
US8728143B2 (en) | 1996-06-06 | 2014-05-20 | Biosensors International Group, Ltd. | Endoprosthesis deployment system for treating vascular bifurcations |
US7238197B2 (en) | 2000-05-30 | 2007-07-03 | Devax, Inc. | Endoprosthesis deployment system for treating vascular bifurcations |
IT1289815B1 (en) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT AND RELATED PRODUCTION PROCESS |
JP4583597B2 (en) * | 1998-05-05 | 2010-11-17 | ボストン サイエンティフィック リミテッド | Smooth end stent |
JP4741728B2 (en) * | 1998-06-04 | 2011-08-10 | ニューヨーク・ユニバーシティ | Intravascular thin film device and stroke treatment |
US8382821B2 (en) | 1998-12-03 | 2013-02-26 | Medinol Ltd. | Helical hybrid stent |
US20040267349A1 (en) * | 2003-06-27 | 2004-12-30 | Kobi Richter | Amorphous metal alloy medical devices |
AU3844499A (en) * | 1999-05-07 | 2000-11-21 | Salviac Limited | Improved filter element for embolic protection device |
JP2002543875A (en) * | 1999-05-07 | 2002-12-24 | サルヴィアック・リミテッド | Improved filter element for embolic protection devices |
DE19951477A1 (en) * | 1999-10-26 | 2001-05-03 | Biotronik Mess & Therapieg | Stent |
US6733513B2 (en) | 1999-11-04 | 2004-05-11 | Advanced Bioprosthetic Surfaces, Ltd. | Balloon catheter having metal balloon and method of making same |
US6379383B1 (en) | 1999-11-19 | 2002-04-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal device exhibiting improved endothelialization and method of manufacture thereof |
US8458879B2 (en) | 2001-07-03 | 2013-06-11 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Method of fabricating an implantable medical device |
EP1239795B1 (en) * | 1999-12-23 | 2006-12-06 | Edwards Lifesciences Corporation | Enhanced visualization of medical implants |
US6355058B1 (en) * | 1999-12-30 | 2002-03-12 | Advanced Cardiovascular Systems, Inc. | Stent with radiopaque coating consisting of particles in a binder |
US7758627B2 (en) | 2000-03-01 | 2010-07-20 | Medinol, Ltd. | Longitudinally flexible stent |
US7141062B1 (en) | 2000-03-01 | 2006-11-28 | Medinol, Ltd. | Longitudinally flexible stent |
US8920487B1 (en) | 2000-03-01 | 2014-12-30 | Medinol Ltd. | Longitudinally flexible stent |
US6723119B2 (en) | 2000-03-01 | 2004-04-20 | Medinol Ltd. | Longitudinally flexible stent |
US7828835B2 (en) | 2000-03-01 | 2010-11-09 | Medinol Ltd. | Longitudinally flexible stent |
SG86458A1 (en) | 2000-03-01 | 2002-02-19 | Medinol Ltd | Longitudinally flexible stent |
US8496699B2 (en) | 2000-03-01 | 2013-07-30 | Medinol Ltd. | Longitudinally flexible stent |
US7621947B2 (en) | 2000-03-01 | 2009-11-24 | Medinol, Ltd. | Longitudinally flexible stent |
US8202312B2 (en) | 2000-03-01 | 2012-06-19 | Medinol Ltd. | Longitudinally flexible stent |
WO2001089421A2 (en) | 2000-05-22 | 2001-11-29 | Orbus Medical Technologies Inc. | Self-expanding stent |
US6652579B1 (en) | 2000-06-22 | 2003-11-25 | Advanced Cardiovascular Systems, Inc. | Radiopaque stent |
US6540775B1 (en) | 2000-06-30 | 2003-04-01 | Cordis Corporation | Ultraflexible open cell stent |
WO2002022050A2 (en) * | 2000-09-12 | 2002-03-21 | Scimed Life Systems, Inc. | Selectively etched radiopaque intraluminal device |
US7118592B1 (en) | 2000-09-12 | 2006-10-10 | Advanced Cardiovascular Systems, Inc. | Covered stent assembly for reduced-shortening during stent expansion |
US7101391B2 (en) * | 2000-09-18 | 2006-09-05 | Inflow Dynamics Inc. | Primarily niobium stent |
US6699278B2 (en) * | 2000-09-22 | 2004-03-02 | Cordis Corporation | Stent with optimal strength and radiopacity characteristics |
US6761708B1 (en) * | 2000-10-31 | 2004-07-13 | Advanced Cardiovascular Systems, Inc. | Radiopaque marker for a catheter and method of making |
AU2002233936A1 (en) | 2000-11-07 | 2002-05-21 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal stent, self-fupporting endoluminal graft and methods of making same |
US7077837B2 (en) * | 2000-11-20 | 2006-07-18 | Implant Sciences Corporation | Multi-layered radiopaque coating on intravascular devices |
US6398806B1 (en) | 2000-12-26 | 2002-06-04 | Scimed Life Systems, Inc. | Monolayer modification to gold coated stents to reduce adsorption of protein |
US6635082B1 (en) | 2000-12-29 | 2003-10-21 | Advanced Cardiovascular Systems Inc. | Radiopaque stent |
JP2002263194A (en) * | 2001-03-13 | 2002-09-17 | Inprest Co Ltd | Stent |
EP1258230A3 (en) | 2001-03-29 | 2003-12-10 | CardioSafe Ltd | Balloon catheter device |
US20020161376A1 (en) * | 2001-04-27 | 2002-10-31 | Barry James J. | Method and system for delivery of coated implants |
DE60120955T3 (en) * | 2001-07-20 | 2015-06-25 | Cid S.P.A. | stent |
GB0121980D0 (en) | 2001-09-11 | 2001-10-31 | Cathnet Science Holding As | Expandable stent |
US7252679B2 (en) * | 2001-09-13 | 2007-08-07 | Cordis Corporation | Stent with angulated struts |
US7776379B2 (en) | 2001-09-19 | 2010-08-17 | Medlogics Device Corporation | Metallic structures incorporating bioactive materials and methods for creating the same |
US20030060873A1 (en) * | 2001-09-19 | 2003-03-27 | Nanomedical Technologies, Inc. | Metallic structures incorporating bioactive materials and methods for creating the same |
US20030077310A1 (en) | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US7294146B2 (en) * | 2001-12-03 | 2007-11-13 | Xtent, Inc. | Apparatus and methods for delivery of variable length stents |
US7182779B2 (en) * | 2001-12-03 | 2007-02-27 | Xtent, Inc. | Apparatus and methods for positioning prostheses for deployment from a catheter |
US8080048B2 (en) | 2001-12-03 | 2011-12-20 | Xtent, Inc. | Stent delivery for bifurcated vessels |
US7147656B2 (en) * | 2001-12-03 | 2006-12-12 | Xtent, Inc. | Apparatus and methods for delivery of braided prostheses |
US20040186551A1 (en) | 2003-01-17 | 2004-09-23 | Xtent, Inc. | Multiple independent nested stent structures and methods for their preparation and deployment |
US7137993B2 (en) * | 2001-12-03 | 2006-11-21 | Xtent, Inc. | Apparatus and methods for delivery of multiple distributed stents |
US20030135266A1 (en) | 2001-12-03 | 2003-07-17 | Xtent, Inc. | Apparatus and methods for delivery of multiple distributed stents |
US7351255B2 (en) | 2001-12-03 | 2008-04-01 | Xtent, Inc. | Stent delivery apparatus and method |
US7309350B2 (en) | 2001-12-03 | 2007-12-18 | Xtent, Inc. | Apparatus and methods for deployment of vascular prostheses |
US7892273B2 (en) | 2001-12-03 | 2011-02-22 | Xtent, Inc. | Custom length stent apparatus |
DK175391B1 (en) * | 2002-02-13 | 2004-09-20 | Danfoss As | Column implant and method of manufacture thereof |
US7083822B2 (en) * | 2002-04-26 | 2006-08-01 | Medtronic Vascular, Inc. | Overlapping coated stents |
US7637935B2 (en) | 2002-05-06 | 2009-12-29 | Abbott Laboratories | Endoprosthesis for controlled contraction and expansion |
WO2003094798A1 (en) | 2002-05-08 | 2003-11-20 | Abbott Laboratories | Endoprosthesis having foot extensions |
US20030225448A1 (en) * | 2002-05-28 | 2003-12-04 | Scimed Life Systems, Inc. | Polar radiopaque marker for stent |
US6945995B2 (en) * | 2002-08-29 | 2005-09-20 | Boston Scientific Scimed, Inc. | Stent overlap point markers |
US6878162B2 (en) | 2002-08-30 | 2005-04-12 | Edwards Lifesciences Ag | Helical stent having improved flexibility and expandability |
US9561123B2 (en) | 2002-08-30 | 2017-02-07 | C.R. Bard, Inc. | Highly flexible stent and method of manufacture |
CA2499961C (en) | 2002-09-26 | 2014-12-30 | Advanced Bio Prosthetic Surfaces, Ltd. | High strength vacuum deposited nitinol alloy films, medical thin film graft materials and method of making same |
JP2006500997A (en) * | 2002-09-27 | 2006-01-12 | メドロジックス デバイス コーポレイション | Implantable stent with modified end |
US6638301B1 (en) * | 2002-10-02 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device with radiopacity |
US20060149365A1 (en) * | 2002-10-22 | 2006-07-06 | Medtronic Vascular, Inc. | Stent with eccentric coating |
US20040093056A1 (en) | 2002-10-26 | 2004-05-13 | Johnson Lianw M. | Medical appliance delivery apparatus and method of use |
US7875068B2 (en) | 2002-11-05 | 2011-01-25 | Merit Medical Systems, Inc. | Removable biliary stent |
US7637942B2 (en) | 2002-11-05 | 2009-12-29 | Merit Medical Systems, Inc. | Coated stent with geometry determinated functionality and method of making the same |
US7959671B2 (en) | 2002-11-05 | 2011-06-14 | Merit Medical Systems, Inc. | Differential covering and coating methods |
AU2002356575B2 (en) | 2002-11-08 | 2009-07-16 | Jean-Claude Laborde | Endoprosthesis for vascular bifurcation |
US20040143317A1 (en) * | 2003-01-17 | 2004-07-22 | Stinson Jonathan S. | Medical devices |
US7637934B2 (en) | 2003-03-31 | 2009-12-29 | Merit Medical Systems, Inc. | Medical appliance optical delivery and deployment apparatus and method |
US7604660B2 (en) | 2003-05-01 | 2009-10-20 | Merit Medical Systems, Inc. | Bifurcated medical appliance delivery apparatus and method |
US7625398B2 (en) | 2003-05-06 | 2009-12-01 | Abbott Laboratories | Endoprosthesis having foot extensions |
US7625401B2 (en) | 2003-05-06 | 2009-12-01 | Abbott Laboratories | Endoprosthesis having foot extensions |
US7241308B2 (en) | 2003-06-09 | 2007-07-10 | Xtent, Inc. | Stent deployment systems and methods |
US9155639B2 (en) | 2009-04-22 | 2015-10-13 | Medinol Ltd. | Helical hybrid stent |
US9039755B2 (en) | 2003-06-27 | 2015-05-26 | Medinol Ltd. | Helical hybrid stent |
US7208172B2 (en) | 2003-11-03 | 2007-04-24 | Medlogics Device Corporation | Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices |
US20060085062A1 (en) * | 2003-11-28 | 2006-04-20 | Medlogics Device Corporation | Implantable stent with endothelialization factor |
US20050119723A1 (en) * | 2003-11-28 | 2005-06-02 | Medlogics Device Corporation | Medical device with porous surface containing bioerodable bioactive composites and related methods |
US7403966B2 (en) * | 2003-12-08 | 2008-07-22 | Freescale Semiconductor, Inc. | Hardware for performing an arithmetic function |
US7326236B2 (en) | 2003-12-23 | 2008-02-05 | Xtent, Inc. | Devices and methods for controlling and indicating the length of an interventional element |
US8992592B2 (en) | 2004-12-29 | 2015-03-31 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
US8632580B2 (en) | 2004-12-29 | 2014-01-21 | Boston Scientific Scimed, Inc. | Flexible medical devices including metallic films |
US8998973B2 (en) | 2004-03-02 | 2015-04-07 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
US8591568B2 (en) | 2004-03-02 | 2013-11-26 | Boston Scientific Scimed, Inc. | Medical devices including metallic films and methods for making same |
US7901447B2 (en) | 2004-12-29 | 2011-03-08 | Boston Scientific Scimed, Inc. | Medical devices including a metallic film and at least one filament |
US7323006B2 (en) | 2004-03-30 | 2008-01-29 | Xtent, Inc. | Rapid exchange interventional devices and methods |
US7763064B2 (en) | 2004-06-08 | 2010-07-27 | Medinol, Ltd. | Stent having struts with reverse direction curvature |
US20050283226A1 (en) * | 2004-06-18 | 2005-12-22 | Scimed Life Systems, Inc. | Medical devices |
US8317859B2 (en) | 2004-06-28 | 2012-11-27 | J.W. Medical Systems Ltd. | Devices and methods for controlling expandable prostheses during deployment |
US20050288766A1 (en) | 2004-06-28 | 2005-12-29 | Xtent, Inc. | Devices and methods for controlling expandable prostheses during deployment |
US7780721B2 (en) | 2004-09-01 | 2010-08-24 | C. R. Bard, Inc. | Stent and method for manufacturing the stent |
US20060064155A1 (en) * | 2004-09-01 | 2006-03-23 | Pst, Llc | Stent and method for manufacturing the stent |
WO2006063181A1 (en) * | 2004-12-06 | 2006-06-15 | Surmodics, Inc. | Multifunctional medical articles |
EP1871292B1 (en) | 2005-04-04 | 2019-10-23 | Flexible Stenting Solutions, Inc. | Flexible stent |
US7854760B2 (en) | 2005-05-16 | 2010-12-21 | Boston Scientific Scimed, Inc. | Medical devices including metallic films |
US20060282149A1 (en) | 2005-06-08 | 2006-12-14 | Xtent, Inc., A Delaware Corporation | Apparatus and methods for deployment of multiple custom-length prostheses (II) |
US7938851B2 (en) | 2005-06-08 | 2011-05-10 | Xtent, Inc. | Devices and methods for operating and controlling interventional apparatus |
EP1895938B1 (en) | 2005-06-30 | 2019-02-20 | Abbott Laboratories | Endoprosthesis having foot extensions |
US11026822B2 (en) | 2006-01-13 | 2021-06-08 | C. R. Bard, Inc. | Stent delivery system |
US20070173925A1 (en) * | 2006-01-25 | 2007-07-26 | Cornova, Inc. | Flexible expandable stent |
EP3127508A1 (en) | 2006-02-14 | 2017-02-08 | Angiomed GmbH & Co. Medizintechnik KG | Highly flexible stent |
US8801777B2 (en) * | 2007-04-18 | 2014-08-12 | David Elmaleh | Intravascular device with netting system |
JP2009530060A (en) | 2006-03-20 | 2009-08-27 | エックステント・インコーポレーテッド | Apparatus and method for deploying connected prosthetic segments |
US20070281117A1 (en) | 2006-06-02 | 2007-12-06 | Xtent, Inc. | Use of plasma in formation of biodegradable stent coating |
GB0615658D0 (en) * | 2006-08-07 | 2006-09-13 | Angiomed Ag | Hand-held actuator device |
US20080177371A1 (en) * | 2006-08-28 | 2008-07-24 | Cornova, Inc. | Implantable devices and methods of forming the same |
US9339593B2 (en) * | 2007-01-11 | 2016-05-17 | Robert L. Bjork, JR. | Drug-eluting coronary artery stent coated with anti-platelet-derived growth factor antibodies overlaying extracellular matrix proteins with an outer coating of anti-inflammatory (calcineurin inhibitor) and/or anti-proliferatives |
EP2101683A4 (en) * | 2007-01-11 | 2014-12-03 | Robert Lamar Bjork Jr | Multiple drug-eluting coronary artery stent for percutaneous coronary artery intervention |
US8333799B2 (en) | 2007-02-12 | 2012-12-18 | C. R. Bard, Inc. | Highly flexible stent and method of manufacture |
US8328865B2 (en) * | 2007-02-12 | 2012-12-11 | C. R. Bard, Inc. | Highly flexible stent and method of manufacture |
US20080199510A1 (en) | 2007-02-20 | 2008-08-21 | Xtent, Inc. | Thermo-mechanically controlled implants and methods of use |
US8486132B2 (en) | 2007-03-22 | 2013-07-16 | J.W. Medical Systems Ltd. | Devices and methods for controlling expandable prostheses during deployment |
GB0713497D0 (en) | 2007-07-11 | 2007-08-22 | Angiomed Ag | Device for catheter sheath retraction |
US7988723B2 (en) | 2007-08-02 | 2011-08-02 | Flexible Stenting Solutions, Inc. | Flexible stent |
US8142490B2 (en) * | 2007-10-24 | 2012-03-27 | Cordis Corporation | Stent segments axially connected by thin film |
WO2009076460A2 (en) * | 2007-12-12 | 2009-06-18 | Cornova, Inc. | Flexible expandable stent and methods of deployment |
KR100947094B1 (en) * | 2008-01-02 | 2010-03-10 | 주식회사 디오 | Stent for medical use and manufacturing method thereof |
US9101503B2 (en) | 2008-03-06 | 2015-08-11 | J.W. Medical Systems Ltd. | Apparatus having variable strut length and methods of use |
US8828071B2 (en) | 2008-09-25 | 2014-09-09 | Advanced Bifurcation Systems, Inc. | Methods and systems for ostial stenting of a bifurcation |
US8808347B2 (en) | 2008-09-25 | 2014-08-19 | Advanced Bifurcation Systems, Inc. | Stent alignment during treatment of a bifurcation |
US8821562B2 (en) | 2008-09-25 | 2014-09-02 | Advanced Bifurcation Systems, Inc. | Partially crimped stent |
EP2344068B1 (en) | 2008-09-25 | 2022-10-19 | Advanced Bifurcation Systems Inc. | Partially crimped stent |
US11298252B2 (en) | 2008-09-25 | 2022-04-12 | Advanced Bifurcation Systems Inc. | Stent alignment during treatment of a bifurcation |
US9149376B2 (en) | 2008-10-06 | 2015-10-06 | Cordis Corporation | Reconstrainable stent delivery system |
EP2338534A2 (en) * | 2009-12-21 | 2011-06-29 | Biotronik VI Patent AG | Medical implant, coating method and implantation method |
EP2549958A4 (en) | 2010-03-24 | 2016-09-14 | Advanced Bifurcation Systems Inc | Methods and systems for treating a bifurcation with provisional side branch stenting |
CN109363807B (en) | 2010-03-24 | 2021-04-02 | 高级分支系统股份有限公司 | System and method for treating a bifurcation |
GB201017834D0 (en) | 2010-10-21 | 2010-12-01 | Angiomed Ag | System to deliver a bodily implant |
EP2672925B1 (en) | 2011-02-08 | 2017-05-03 | Advanced Bifurcation Systems, Inc. | Multi-stent and multi-balloon apparatus for treating bifurcations |
EP2672932B1 (en) | 2011-02-08 | 2018-09-19 | Advanced Bifurcation Systems, Inc. | System for treating a bifurcation with a fully crimped stent |
WO2014062713A1 (en) | 2012-10-15 | 2014-04-24 | Elmaleh David R | Material structures for intravascular device |
EP2952160A4 (en) * | 2013-01-30 | 2016-08-17 | Terumo Corp | Organism lumen treatment system, and stent |
KR101690178B1 (en) | 2014-12-19 | 2016-12-27 | 공주대학교 산학협력단 | High precision stent spin coating apparatus and the method thereof |
KR101651635B1 (en) * | 2014-12-30 | 2016-08-29 | 충남대학교산학협력단 | Magnetic resonance image distortion relaxation method of biomatters |
US9456914B2 (en) | 2015-01-29 | 2016-10-04 | Intact Vascular, Inc. | Delivery device and method of delivery |
KR101761797B1 (en) | 2015-08-12 | 2017-07-26 | 주식회사 시브이바이오 | The biodegradable stent |
KR102032752B1 (en) * | 2017-08-29 | 2019-10-17 | (주)시지바이오 | Stent and preparing method of the same |
RU184121U1 (en) * | 2017-10-06 | 2018-10-16 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) | STENT SELF-EXTENDING COLORECTAL |
US10709463B2 (en) | 2017-12-11 | 2020-07-14 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
US11058444B2 (en) | 2017-12-11 | 2021-07-13 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
CA3101217C (en) | 2018-06-11 | 2023-03-28 | Boston Scientific Scimed, Inc. | Sphincterotomes and methods for using sphincterotomes |
US10874411B2 (en) | 2018-06-22 | 2020-12-29 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
DE102018218130A1 (en) * | 2018-10-23 | 2020-04-23 | Karlsruher Institut für Technologie | Stent for implantation in a cavity of a human or animal body and method for producing an X-ray-opaque layer structure on a stent |
US11612430B2 (en) | 2019-03-19 | 2023-03-28 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
US11191558B2 (en) | 2019-06-12 | 2021-12-07 | Covidien Lp | Retrieval of material from corporeal lumens |
US11523838B2 (en) | 2019-06-12 | 2022-12-13 | Covidien Lp | Retrieval of material from corporeal lumens |
US11395668B2 (en) | 2019-12-12 | 2022-07-26 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
US11944557B2 (en) | 2020-08-31 | 2024-04-02 | Boston Scientific Scimed, Inc. | Self expanding stent with covering |
US11963713B2 (en) * | 2021-06-02 | 2024-04-23 | Covidien Lp | Medical treatment system |
US11944374B2 (en) | 2021-08-30 | 2024-04-02 | Covidien Lp | Electrical signals for retrieval of material from vessel lumens |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
EP0556940A1 (en) | 1986-02-24 | 1993-08-25 | Robert E. Fischell | Intravascular stent |
US5024232A (en) | 1986-10-07 | 1991-06-18 | The Research Foundation Of State University Of Ny | Novel radiopaque heavy metal polymer complexes, compositions of matter and articles prepared therefrom |
US4969458A (en) | 1987-07-06 | 1990-11-13 | Medtronic, Inc. | Intracoronary stent and method of simultaneous angioplasty and stent implant |
WO1989003197A1 (en) | 1987-10-08 | 1989-04-20 | Terumo Kabushiki Kaisha | Instrument and apparatus for securing inner diameter of lumen of tubular organ |
US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
US5019090A (en) | 1988-09-01 | 1991-05-28 | Corvita Corporation | Radially expandable endoprosthesis and the like |
US5207706A (en) | 1988-10-05 | 1993-05-04 | Menaker M D Gerald | Method and means for gold-coating implantable intravascular devices |
US5464438A (en) | 1988-10-05 | 1995-11-07 | Menaker; Gerald J. | Gold coating means for limiting thromboses in implantable grafts |
US4950227A (en) | 1988-11-07 | 1990-08-21 | Boston Scientific Corporation | Stent delivery system |
US4856516A (en) | 1989-01-09 | 1989-08-15 | Cordis Corporation | Endovascular stent apparatus and method |
US4994071A (en) * | 1989-05-22 | 1991-02-19 | Cordis Corporation | Bifurcating stent apparatus and method |
US5628790A (en) | 1989-07-25 | 1997-05-13 | Smith & Nephew, Inc. | Zirconium oxide zirconium nitride coated valvular annuloplasty rings |
US5611347A (en) | 1989-07-25 | 1997-03-18 | Smith & Nephew, Inc. | Zirconium oxide and zirconium nitride coated percutaneous devices |
US5176617A (en) | 1989-12-11 | 1993-01-05 | Medical Innovative Technologies R & D Limited Partnership | Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct |
US5344425A (en) | 1990-09-14 | 1994-09-06 | Interface Biomedical Laboratories, Corp. | Intravascular stent and method for conditioning the surfaces thereof |
US5161547A (en) | 1990-11-28 | 1992-11-10 | Numed, Inc. | Method of forming an intravascular radially expandable stent |
US5314472A (en) | 1991-10-01 | 1994-05-24 | Cook Incorporated | Vascular stent |
EP0633798B1 (en) * | 1992-03-31 | 2003-05-07 | Boston Scientific Corporation | Vascular filter |
US5630840A (en) | 1993-01-19 | 1997-05-20 | Schneider (Usa) Inc | Clad composite stent |
ES2166370T3 (en) * | 1993-01-19 | 2002-04-16 | Schneider Usa Inc | IMPLANTABLE FILAMENT IN COMPOSITE MATERIAL. |
US5609627A (en) * | 1994-02-09 | 1997-03-11 | Boston Scientific Technology, Inc. | Method for delivering a bifurcated endoluminal prosthesis |
US5733303A (en) | 1994-03-17 | 1998-03-31 | Medinol Ltd. | Flexible expandable stent |
JP2825452B2 (en) * | 1994-04-25 | 1998-11-18 | アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド | Radiopak stent marker |
US5636641A (en) | 1994-07-25 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | High strength member for intracorporeal use |
US5649977A (en) | 1994-09-22 | 1997-07-22 | Advanced Cardiovascular Systems, Inc. | Metal reinforced polymer stent |
IL115755A0 (en) * | 1994-10-27 | 1996-01-19 | Medinol Ltd | X-ray visible stent |
DE19506188C2 (en) | 1995-02-22 | 2003-03-06 | Miladin Lazarov | Implant and its use |
FR2733682B1 (en) * | 1995-05-04 | 1997-10-31 | Dibie Alain | ENDOPROSTHESIS FOR THE TREATMENT OF STENOSIS ON BIFURCATIONS OF BLOOD VESSELS AND LAYING EQUIPMENT THEREFOR |
US5607442A (en) * | 1995-11-13 | 1997-03-04 | Isostent, Inc. | Stent with improved radiopacity and appearance characteristics |
US6174329B1 (en) * | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
US5824045A (en) | 1996-10-21 | 1998-10-20 | Inflow Dynamics Inc. | Vascular and endoluminal stents |
US5858556A (en) * | 1997-01-21 | 1999-01-12 | Uti Corporation | Multilayer composite tubular structure and method of making |
DE29701758U1 (en) | 1997-02-01 | 1997-03-27 | Jomed Implantate Gmbh | Radially expandable stent for implantation in a body vessel, particularly in the area of a vascular branch |
US5919126A (en) * | 1997-07-07 | 1999-07-06 | Implant Sciences Corporation | Coronary stent with a radioactive, radiopaque coating |
-
1998
- 1998-08-21 NO NO19983878A patent/NO311781B1/en not_active IP Right Cessation
- 1998-08-23 WO PCT/IL1998/000401 patent/WO1999025272A1/en active Application Filing
- 1998-08-23 AU AU88829/98A patent/AU8882998A/en not_active Abandoned
- 1998-08-23 IL IL12589798A patent/IL125897A/en not_active IP Right Cessation
- 1998-08-24 SG SG1998003283A patent/SG67545A1/en unknown
- 1998-08-25 NZ NZ331532A patent/NZ331532A/en unknown
- 1998-08-25 CA CA002245805A patent/CA2245805C/en not_active Expired - Fee Related
- 1998-08-26 AU AU81929/98A patent/AU757255B2/en not_active Ceased
- 1998-08-31 AR ARP980104342A patent/AR015161A1/en not_active Application Discontinuation
- 1998-09-03 PL PL98328338A patent/PL328338A1/en unknown
- 1998-09-07 KR KR1019980036711A patent/KR100309485B1/en not_active IP Right Cessation
- 1998-09-21 CN CN98119664A patent/CN1217216A/en active Pending
- 1998-09-23 BR BR9803598-3A patent/BR9803598A/en not_active IP Right Cessation
- 1998-10-06 DE DE69839141T patent/DE69839141T2/en not_active Expired - Lifetime
- 1998-10-06 AT AT98118836T patent/ATE386476T1/en not_active IP Right Cessation
- 1998-10-06 EP EP98118836A patent/EP0916317B1/en not_active Revoked
- 1998-10-06 DE DE19846013A patent/DE19846013A1/en not_active Ceased
- 1998-10-19 CZ CZ983355A patent/CZ335598A3/en unknown
- 1998-10-21 SK SK1458-98A patent/SK145898A3/en unknown
- 1998-11-06 UA UA98115916A patent/UA53646C2/en unknown
- 1998-11-10 RU RU98120257/14A patent/RU2211684C2/en not_active IP Right Cessation
- 1998-11-12 JP JP32206798A patent/JP3640007B2/en not_active Expired - Fee Related
- 1998-11-12 EE EE9800313A patent/EE03801B1/en not_active IP Right Cessation
- 1998-11-13 GB GB9824854A patent/GB2331246B/en not_active Expired - Fee Related
-
1999
- 1999-06-18 US US09/335,599 patent/US6315794B1/en not_active Expired - Fee Related
-
2001
- 2001-09-24 US US09/961,935 patent/US20020010505A1/en not_active Abandoned
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US6926734B1 (en) * | 1996-05-29 | 2005-08-09 | Avantec Vascular Corporation | Radially expansible vessel scaffold having modified radiopacity |
US8066763B2 (en) | 1998-04-11 | 2011-11-29 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US20100286763A1 (en) * | 1998-04-11 | 2010-11-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US8480599B2 (en) | 1998-06-17 | 2013-07-09 | Abbott Cardiovascular Systems, Inc. | Composite radiopaque intracorporeal product |
US20110166479A1 (en) * | 1998-06-17 | 2011-07-07 | Abbott Cardiovascular Systems, Inc. | Composite radiopaque intracorporeal product |
US7905003B2 (en) | 1998-06-17 | 2011-03-15 | Abbott Cardiovascular Systems Inc. | Process for proving a composite radiopaque intracorporeal product |
US7294356B2 (en) * | 1998-06-17 | 2007-11-13 | Advanced Cardiovascular Systems, Inc. | Performance enhancing coating on intraluminal devices |
US20030093011A1 (en) * | 1998-06-17 | 2003-05-15 | Jalisi Marc Mehrzad | Performance enhancing coating on intraluminal devices |
US20080228108A1 (en) * | 1998-06-17 | 2008-09-18 | Marc Mehrzad Jalisi | Composite Radiopaque Intracorporeal Product |
US8303643B2 (en) | 2001-06-27 | 2012-11-06 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US20060155370A1 (en) * | 2002-10-22 | 2006-07-13 | Medtronic Vascular, Inc. | Stent with intermittent coating |
US8435286B2 (en) * | 2002-10-22 | 2013-05-07 | Medtronic Vascular, Inc. | Stent with intermittent coating |
WO2004103220A3 (en) * | 2003-05-15 | 2005-02-03 | Scimed Life Systems Inc | Medical devices and methods of making the same |
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US20050131522A1 (en) * | 2003-12-10 | 2005-06-16 | Stinson Jonathan S. | Medical devices and methods of making the same |
US8057841B2 (en) | 2004-02-12 | 2011-11-15 | University Of Akron | Mechanically attached medical device coatings |
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US7955373B2 (en) * | 2004-06-28 | 2011-06-07 | Boston Scientific Scimed, Inc. | Two-stage stent-graft and method of delivering same |
US20050288768A1 (en) * | 2004-06-28 | 2005-12-29 | Krzysztof Sowinski | Two-stage stent-graft and method of delivering same |
US20100280612A1 (en) * | 2004-12-09 | 2010-11-04 | Boston Scientific Scimed, Inc. | Medical Devices Having Vapor Deposited Nanoporous Coatings For Controlled Therapeutic Agent Delivery |
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US20080130520A1 (en) * | 2005-06-09 | 2008-06-05 | Whirlpool Corporation | Network for communicating information related to a consumable to an appliance |
US20070038176A1 (en) * | 2005-07-05 | 2007-02-15 | Jan Weber | Medical devices with machined layers for controlled communications with underlying regions |
US20070156231A1 (en) * | 2006-01-05 | 2007-07-05 | Jan Weber | Bioerodible endoprostheses and methods of making the same |
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US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
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US20070224244A1 (en) * | 2006-03-22 | 2007-09-27 | Jan Weber | Corrosion resistant coatings for biodegradable metallic implants |
US20100233238A1 (en) * | 2006-03-24 | 2010-09-16 | Boston Scientific Scimed, Inc. | Medical Devices Having Nanoporous Coatings for Controlled Therapeutic Agent Delivery |
US8574615B2 (en) | 2006-03-24 | 2013-11-05 | Boston Scientific Scimed, Inc. | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
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US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
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US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US20110189377A1 (en) * | 2006-05-12 | 2011-08-04 | Boston Scientific Scimed, Inc. | Coating for Medical Devices Comprising An Inorganic or Ceramic Oxide and a Therapeutic Agent |
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US20070270942A1 (en) * | 2006-05-19 | 2007-11-22 | Medtronic Vascular, Inc. | Galvanic Corrosion Methods and Devices for Fixation of Stent Grafts |
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US8128689B2 (en) | 2006-09-15 | 2012-03-06 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
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US20080183277A1 (en) * | 2006-09-15 | 2008-07-31 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US20080071350A1 (en) * | 2006-09-18 | 2008-03-20 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8002821B2 (en) | 2006-09-18 | 2011-08-23 | Boston Scientific Scimed, Inc. | Bioerodible metallic ENDOPROSTHESES |
US20080071357A1 (en) * | 2006-09-18 | 2008-03-20 | Girton Timothy S | Controlling biodegradation of a medical instrument |
US20080086195A1 (en) * | 2006-10-05 | 2008-04-10 | Boston Scientific Scimed, Inc. | Polymer-Free Coatings For Medical Devices Formed By Plasma Electrolytic Deposition |
US20080140176A1 (en) * | 2006-10-18 | 2008-06-12 | Krause Arthur A | Medical stent and devices for localized treatment of disease |
US7981150B2 (en) * | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
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US8080055B2 (en) | 2006-12-28 | 2011-12-20 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
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US20090018639A1 (en) * | 2007-07-11 | 2009-01-15 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
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US20100228341A1 (en) * | 2009-03-04 | 2010-09-09 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
US20100274352A1 (en) * | 2009-04-24 | 2010-10-28 | Boston Scientific Scrimed, Inc. | Endoprosthesis with Selective Drug Coatings |
US20100272882A1 (en) * | 2009-04-24 | 2010-10-28 | Boston Scientific Scimed, Inc. | Endoprosthese |
US20110022158A1 (en) * | 2009-07-22 | 2011-01-27 | Boston Scientific Scimed, Inc. | Bioerodible Medical Implants |
US20110238151A1 (en) * | 2010-03-23 | 2011-09-29 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
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