US20020188171A1 - Lung reduction apparatus and method - Google Patents
Lung reduction apparatus and method Download PDFInfo
- Publication number
- US20020188171A1 US20020188171A1 US10/199,776 US19977602A US2002188171A1 US 20020188171 A1 US20020188171 A1 US 20020188171A1 US 19977602 A US19977602 A US 19977602A US 2002188171 A1 US2002188171 A1 US 2002188171A1
- Authority
- US
- United States
- Prior art keywords
- jacket
- lung
- cord
- free ends
- lung portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
Abstract
An apparatus and method reduces the size of a lung. The apparatus includes a jacket of flexible fabric configured to cover at least a portion of the lung. A lace, carried by the jacket, collapses the jacket about the lung portion. The jacket may further include a drawstring circumscribing the jacket at the base for closing the open base of the jacket about the lung portion. The collapsing of the jacket may be employed for both reducing the size of the lung and maintaining the lung in a reduced size condition or the lung portion may be deflated prior to the placement of the jacket over the lung portion, in which case, the jacket serves to prevent re-expansion of the lung portion.
Description
- The present invention is generally directed to an apparatus and method for treating Chronic Obstructive Pulmonary Disease (COPD). The present invention is more particularly directed to such an apparatus and method which may be implanted in the human body to provide lung size reduction by constricting at least a portion of a lung.
- Chronic Obstructive Pulmonary Disease (COPD) has become a major cause of morbidity and mortality in the United States over the last three decades. COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema. The airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles.
- The incidence, prevalence, and health-related costs of COPD are on the rise. Mortality due to COPD is also on the rise. In 1991 COPD was the fourth leading cause of death in the United States and had increased 33% since 1979.
- COPD affects the patient's whole life. It has three main symptoms: cough; breathlessness; and wheeze. At first, breathlessness may be noticed when running for a bus, digging in the garden, or walking up hill. Later, it may be noticed when simply walking in the kitchen. Overtime, it may occur with less and less effort until it is present all of the time.
- COPD is a progressive disease and currently has no cure. Current treatments for COPD include the prevention of further respiratory damage, pharmacotherapy, and surgery. Each is discussed below.
- The prevention of further respiratory damage entails the adoption of a healthy lifestyle. Smoking cessation is believed to be the single most important therapeutic intervention. However, regular exercise and weight control are also important. Patients whose symptoms restrict their daily activities or who otherwise have an impaired quality of life may require a pulmonary rehabilitation program including ventilatory muscle training and breathing retraining. Long-term oxygen therapy may also become necessary.
- Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled ∃-agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, Ipratropium bromide may be indicated. Further, courses of steroids, such as corticosterocds, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pheumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD.
- About 40 years ago, it was first postulated that the tethering force that tends to keep the intrathoracic airways open was lost in emphysema and that by surgically removing the most affected parts of the lungs, the force could be partially restored. Although the surgery was deemed promising, the procedure was abandoned.
- The lung volume reduction surgery (LVRS) was later revived. In the early 1990's, hundreds of patients underwent the procedure. However, the procedure has fallen out of favor due to the fact that Medicare stopped remitting for LVRS. Unfortunately, data is relatively scarce and many factors conspire to make what data exists difficult to interpret. The procedure is currently under review in a controlled clinical trial. However, what data does exist tends to indicate that patients benefited from the procedure in terms of an increase in forced expiratory volume, a decrease in total lung capacity, and a significant improvement in lung function, dyspnea, and quality of life.
- Improvements in pulmonary function after LVRS have been attributed to at least four possible mechanisms. These include enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricular filling.
- Lastly, lung tranplantation is also an option. Today, COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients.
- In view of the foregoing, there in a need in the art for a new and improved therapy for COPD. More specifically, there is a need for such a therapy which provides more permanent results than pharmacotherapy while being less traumatic than LVRS. The present invention is directed to an apparatus and method which provide such an improved therapy for COPD.
- The present invention provides an implantable apparatus for reducing the size of a lung. The apparatus includes a jacket of flexible fabric configured to cover at least a portion of a lung and collapsing means carried by the jacket for collapsing the jacket about the lung portion.
- The invention still further provides a method of reducing the size of a lung. The method includes the steps of disposing a jacket of flexible fabric over at least a portion of a lung. The collapsing of the jacket may serve to both reduce the size of the lung and maintain it in its reduced size condition. Alternatively, the lung portion may first be deflated whereupon the collapsed jacket serves to maintain the lung portion in a deflated, reduced size condition.
- The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like referenced numerals identify identical elements, and wherein:
- FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system;
- FIG. 2 is a sectional view similar to FIG. 1 but illustrating a respiratory system suffering from COPD;
- FIG. 3 is a perspective view illustrating a lung constriction apparatus embodying the present invention;
- FIG. 4 is a sectional view of the respiratory system of FIG. 2 with a lung constriction apparatus embodying the present invention being disposed over a lung portion to be reduced in size;
- FIG. 5 illustrates an initial step in collapsing the lung constricting apparatus about the lung portion;
- FIG. 6 illustrates a further step in collapsing the lung constriction apparatus;
- FIG. 7 illustrates the lung constricting apparatus being fully collapsed about the lung portion; and
- FIG. 8 illustrates the respiratory system after both left and right side lung portions have been reduced in size in accordance with the present invention.
- Referring now to FIG. 1, it is a sectional view of a healthy respiratory system. The
respiratory system 20 resides within thethorax 22 which occupies a space defined by thechest wall 24 and thediaphragm 26. - The
respiratory system 20 includes thetrachea 28, theleft mainstem bronchus 30, theright mainstem bronchus 32, and thebronchial branches respiratory system 20 further includesleft lung lobes right lung lobes - Characteristic of a healthy respiratory system is the arched or inwardly
arcuate diaphragm 26. As the individual inhales, thediaphragm 26 straightens to increase the volume of thethorax 22. This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air. When the individual exhales, the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes. - In contrast to the healthy respiratory system of FIG. 1, FIG. 2 illustrates a respiratory system suffering from COPD. Here it may be seen that the
lung lobes diaphragm 26 is not arched but substantially straight. Hence, this individual is incapable of breathing normally by moving thediaphragm 28. Instead, in order to create the negative pressure in thethorax 22 required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths. - It has been found that the
apex portion upper lung lobes upper lung lobe 56. However, as will be appreciated by those skilled in the art, the present invention may be applied to any lung portion without departing from the present invention. - The apparatus and method of the present invention treats COPD by deriving the benefits of lung volume reduction surgery without the need of performing lung volume reduction surgery. As will be seen hereinafter, the present invention contemplates permanent collapse of a lung portion or lung portions most affected. This leaves extra volume within the thorax for the diaphragm to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.
- Referring now to FIG. 3, it illustrates a
lung constriction apparatus 70 embodying the present invention. Theapparatus 70 takes the form of ajacket 72 formed of a flexible fabric such as an open mesh of polyester. The jacket includes anopen base 74 and acurved surface 76 extending from theopen base 74 and terminating in a closed, domed-shape end orapex 78. Theopen base 74 is dimensioned to be applied over and to cover the lung portion to be reduced in size. - The
constriction apparatus 70 further includes at least onelace 80 extending from the apex 78 to thebase 74. Thecord 82 forming thelace 80 has a pair of free ends 84 and 86 which are threaded through aguide tube 88 from thedistal end 90 of theguide tube 88 to theproximal end 92 of theguide tube 88. - The
guide tube 88 serves to maintain the free ends 84 and 86 of thecord 82 together. When the free ends 84 and 86 of thecord 82 are drawn while holding the guide tubedistal end 90 adjacent thebase 74, thejacket 72 is collapsed to reduce the inner volume of the jacket. This constriction of the jacket serves to collapse the jacket about the lung portion to be reduced in size. - As will be seen hereinafter, a plurality of laces may be carried by the jacket. As each lace is drawn, the jacket will be collapsed to a greater and controlled extent.
- The
jacket 72 further includes a piping 94 at thebase 74. Adraw string 96 is threaded through the piping to circumscribe thejacket 72 and thebase 74. The draw string has a pair of free ends 98 and 100. As will be seen hereinafter, after the laces are drawn to collapse thejacket 72 about the lung portion, the free ends 98 and 100 of thedraw string 96 may be pulled and drawn to close theopen base 74 of thejacket 72 about the lung portion. This will provide additional constriction to assure that the lung portion does not reinflate. It also serves to cut off all blood circulation to the lung portion. This promotes infarction and fibrosis. - Referring now to FIG. 4, it illustrates the
constriction device 70 after it has been placed over the apex of the upperright lung lobe 56 to cover thelung portion 66 of the rightupper lobe 56 referred to previously with respect to FIG. 2. Thejacket 72 covers thelung portion 66. At this point, the free ends 84 and 86 of the cord forming thelace 80 have not been drawn. - Referring now to FIG. 5, here it may be seen that the
lace 80 has been drawn by the pulling of the free ends 84 and 86 of the lace cord while holding theguide tube 88 such that itsdistal end 90 is closely adjacent thebase 74 of thejacket 72. As will be observed in FIG. 5, because thejacket 72 has been collapsed about thelung portion 66 of theupper lobe 56, thelung portion 66 has been reduced in size due to the constriction of thejacket 72. - FIG. 6 illustrates the
jacket 72 withadditional laces lung portion 66 of the upperright lobe 56 is now more fully reduced in size by the constriction of thejacket 72. - FIG. 7 illustrates the further constriction provided by the drawstring after being pulled. The free ends of the drawstring after being pulled may be then tied together and cut as illustrated. As can be seen in FIG. 7, the
lung portion 66 of the upperright lobe 56 has been drastically reduced in size. Further, the drawstring constriction will cut off circulation to thelung portion 66 to promote infarction and fibrosis. - FIG. 8 illustrates the respiratory system after both the
lung portion 66 of the upperright lobe 56 and thelung portion 62 of the upperleft lobe 52 have been treated as described above. Here it can be seen that the volumes of the rightupper lung lobe 56 and leftupper lung lobe 52 have been reduced in size by thejacket 72. This causes the lung lobes to occupy less volume within thethorax 22 to permit thediaphragm 26 to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling. - As can thus be seen from the foregoing, the present invention provides an apparatus and method for treating COPD by lung volume reduction. The lung volume reduction is achieved through the permanent collapsing of one or more lung portions, or lobes, or portions of lobes. The foregoing is achieved without the need for removing lung tissue. Following the treatment, the lung tissue within the thorax will occupy a lesser volume than previously occupied providing room for the diaphragm to assume its arcuate state to assist in normal breathing and to achieve the benefits of lung volume reduction.
- While particular embodiments of the present invention have been shown and described, modifications may be made. For example, while the jacket may be employed for reducing the size of a lung by constriction, the invention is not intended to be so limited. Rather, the lung portion may become deflated during surgery on its own or by other means known in the art. The jacket may then be placed on the lung portion while it is in a deflated condition. The jacket may then be collapsed about the lung portion to cinch down over the lung to maintain it in its deflated, reduced volume condition. The jacket would thus prevent re-expansion of the captured lung portion. The remaining portions of the lung may then be expanded, if necessary, by means known in the art. Hence, it is intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention.
Claims (18)
1. An implantable apparatus for reducing the size of a lung comprising:
a jacket of flexible fabric configured to cover at least a portion of a lung; and
collapsing means for collapsing the jacket about the lung portion.
2. The apparatus of claim 1 wherein the flexible fabric is an open mesh material.
3. The apparatus of claim 1 wherein the jacket includes an opening for applying the jacket to the lung portion, and a closed end.
4. The apparatus of claim 3 wherein the jacket includes a base defining the opening.
5. The apparatus of claim 4 wherein the collapsing means is carried by the jacket and comprises at least one lace extending from the closed end towards the base, the at least one lace including a cord having a pair of free ends which, when drawn, collapse the jacket about the lung portion.
6. The apparatus of claim 5 further including a guide tube having a distal end and a proximal end and wherein the free ends of the cord are threaded from the distal end of the guide tube to and through the proximal end of the guide tube.
7. The apparatus of claim 6 wherein the distal end of the guide tube is closely adjacent the base of the jacket.
8. The apparatus of claim 4 wherein the collapsing means includes a draw string circumscribing the jacket at the base, the draw string having a pair of free ends which, when drawn, close the open base of the jacket about the lung portion.
9. The apparatus of claim 1 wherein the flexible fabric is formed of polyester.
10. A method of reducing the size of a lung, the method including the steps of:
disposing a jacket of flexible fabric over at least a portion of a lung; and
collapsing the jacket about the lung portion.
11. The method of claim 10 wherein the open flexible fabric is an open mesh material.
12. The method of claim 11 wherein the open mesh material is a polyester mesh.
13. The method of claim 10 including the step of providing the jacket with a closed end and an opening to permit disposing the jacket over the lung portion.
14. The method of claim 13 wherein the collapsing step includes lacing a cord on the jacket from the closed end towards the opening, the cord when laced having a pair of free ends, and pulling on the free ends of the cord to cause the jacket to collapse about the lung portion.
15. The method of claim 14 wherein the collapsing step further includes tying the free ends of the cord together after the jacket is collapsed about the lung portion.
16. The method of claim 13 wherein the collapsing step includes circumscribing the opening with a cord, the cord having a pair of free ends, and pulling on the free ends of the cord to collapse the opening of the jacket about the lung portion.
17. The method of claim 16 wherein the collapsing step further includes typing the free ends of the cord together after the opening of the jacket is collapsed about the lung portion.
18. The method of claim 10 including the further step of deflating the lung portion prior to disposing the jacket over the lung portion.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/199,776 US20020188171A1 (en) | 1999-08-24 | 2002-07-18 | Lung reduction apparatus and method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/379,973 US6416554B1 (en) | 1999-08-24 | 1999-08-24 | Lung reduction apparatus and method |
US10/199,776 US20020188171A1 (en) | 1999-08-24 | 2002-07-18 | Lung reduction apparatus and method |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/379,973 Continuation US6416554B1 (en) | 1999-08-24 | 1999-08-24 | Lung reduction apparatus and method |
Publications (1)
Publication Number | Publication Date |
---|---|
US20020188171A1 true US20020188171A1 (en) | 2002-12-12 |
Family
ID=23499438
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/379,973 Expired - Lifetime US6416554B1 (en) | 1999-08-24 | 1999-08-24 | Lung reduction apparatus and method |
US10/199,776 Abandoned US20020188171A1 (en) | 1999-08-24 | 2002-07-18 | Lung reduction apparatus and method |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/379,973 Expired - Lifetime US6416554B1 (en) | 1999-08-24 | 1999-08-24 | Lung reduction apparatus and method |
Country Status (3)
Country | Link |
---|---|
US (2) | US6416554B1 (en) |
AU (1) | AU772041B2 (en) |
CA (1) | CA2316707C (en) |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040078054A1 (en) * | 1998-06-05 | 2004-04-22 | Broncus Technologies, Inc. | Method for lung volume reduction |
US7670282B2 (en) | 2004-06-14 | 2010-03-02 | Pneumrx, Inc. | Lung access device |
US7682332B2 (en) | 2003-07-15 | 2010-03-23 | Portaero, Inc. | Methods to accelerate wound healing in thoracic anastomosis applications |
US7686013B2 (en) | 2006-01-17 | 2010-03-30 | Portaero, Inc. | Variable resistance pulmonary ventilation bypass valve |
US7753052B2 (en) | 2003-06-05 | 2010-07-13 | Portaero, Inc. | Intra-thoracic collateral ventilation bypass system |
US7766938B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
US7766891B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Lung device with sealing features |
US7789083B2 (en) | 2003-05-20 | 2010-09-07 | Portaero, Inc. | Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease |
US7811274B2 (en) | 2003-05-07 | 2010-10-12 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
US7824366B2 (en) | 2004-12-10 | 2010-11-02 | Portaero, Inc. | Collateral ventilation device with chest tube/evacuation features and method |
US7896008B2 (en) | 2003-06-03 | 2011-03-01 | Portaero, Inc. | Lung reduction system |
US7909803B2 (en) | 2008-02-19 | 2011-03-22 | Portaero, Inc. | Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease |
US7931641B2 (en) | 2007-05-11 | 2011-04-26 | Portaero, Inc. | Visceral pleura ring connector |
US8062315B2 (en) * | 2007-05-17 | 2011-11-22 | Portaero, Inc. | Variable parietal/visceral pleural coupling |
US8104474B2 (en) | 2005-08-23 | 2012-01-31 | Portaero, Inc. | Collateral ventilation bypass system with retention features |
US8142455B2 (en) | 2006-03-13 | 2012-03-27 | Pneumrx, Inc. | Delivery of minimally invasive lung volume reduction devices |
US8163034B2 (en) | 2007-05-11 | 2012-04-24 | Portaero, Inc. | Methods and devices to create a chemically and/or mechanically localized pleurodesis |
US8220460B2 (en) | 2004-11-19 | 2012-07-17 | Portaero, Inc. | Evacuation device and method for creating a localized pleurodesis |
US8336540B2 (en) | 2008-02-19 | 2012-12-25 | Portaero, Inc. | Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease |
US8347881B2 (en) | 2009-01-08 | 2013-01-08 | Portaero, Inc. | Pneumostoma management device with integrated patency sensor and method |
US8475389B2 (en) | 2008-02-19 | 2013-07-02 | Portaero, Inc. | Methods and devices for assessment of pneumostoma function |
US8518053B2 (en) | 2009-02-11 | 2013-08-27 | Portaero, Inc. | Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease |
US8632605B2 (en) | 2008-09-12 | 2014-01-21 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US8721734B2 (en) | 2009-05-18 | 2014-05-13 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US8740921B2 (en) | 2006-03-13 | 2014-06-03 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US9125639B2 (en) | 2004-11-23 | 2015-09-08 | Pneumrx, Inc. | Steerable device for accessing a target site and methods |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5954766A (en) * | 1997-09-16 | 1999-09-21 | Zadno-Azizi; Gholam-Reza | Body fluid flow control device |
US6328689B1 (en) | 2000-03-23 | 2001-12-11 | Spiration, Inc., | Lung constriction apparatus and method |
US8474460B2 (en) | 2000-03-04 | 2013-07-02 | Pulmonx Corporation | Implanted bronchial isolation devices and methods |
US20030070683A1 (en) * | 2000-03-04 | 2003-04-17 | Deem Mark E. | Methods and devices for use in performing pulmonary procedures |
US6679264B1 (en) | 2000-03-04 | 2004-01-20 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
US6514290B1 (en) * | 2000-03-31 | 2003-02-04 | Broncus Technologies, Inc. | Lung elastic recoil restoring or tissue compressing device and method |
US6941950B2 (en) * | 2001-10-11 | 2005-09-13 | Emphasys Medical, Inc. | Bronchial flow control devices and methods of use |
US7798147B2 (en) | 2001-03-02 | 2010-09-21 | Pulmonx Corporation | Bronchial flow control devices with membrane seal |
US20040074491A1 (en) * | 2001-03-02 | 2004-04-22 | Michael Hendricksen | Delivery methods and devices for implantable bronchial isolation devices |
US6491706B1 (en) * | 2001-07-10 | 2002-12-10 | Spiration, Inc. | Constriction device including fixation structure |
US20030050648A1 (en) | 2001-09-11 | 2003-03-13 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US6592594B2 (en) | 2001-10-25 | 2003-07-15 | Spiration, Inc. | Bronchial obstruction device deployment system and method |
US10098640B2 (en) | 2001-12-04 | 2018-10-16 | Atricure, Inc. | Left atrial appendage devices and methods |
US6929637B2 (en) | 2002-02-21 | 2005-08-16 | Spiration, Inc. | Device and method for intra-bronchial provision of a therapeutic agent |
WO2003075796A2 (en) * | 2002-03-08 | 2003-09-18 | Emphasys Medical, Inc. | Methods and devices for inducing collapse in lung regions fed by collateral pathways |
US20030181922A1 (en) | 2002-03-20 | 2003-09-25 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US20030216769A1 (en) | 2002-05-17 | 2003-11-20 | Dillard David H. | Removable anchored lung volume reduction devices and methods |
US20030195385A1 (en) * | 2002-04-16 | 2003-10-16 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
WO2003096881A2 (en) * | 2002-05-14 | 2003-11-27 | University Of Pittsburgh | Device and method of use for functional isolation of animal or human tissues |
EP1507491A1 (en) * | 2002-05-28 | 2005-02-23 | Emphasys Medical, Inc. | Implantable bronchial isolation devices and lung treatment methods |
US20040059263A1 (en) * | 2002-09-24 | 2004-03-25 | Spiration, Inc. | Device and method for measuring the diameter of an air passageway |
ATE407629T1 (en) | 2002-07-26 | 2008-09-15 | Emphasys Medical Inc | BRONCHIAL FLOW DEVICE WITH A MEMBRANE SEAL |
US7814912B2 (en) | 2002-11-27 | 2010-10-19 | Pulmonx Corporation | Delivery methods and devices for implantable bronchial isolation devices |
US20060052669A1 (en) * | 2003-01-24 | 2006-03-09 | Hart Charles C | Internal tissue retractor |
US7100616B2 (en) * | 2003-04-08 | 2006-09-05 | Spiration, Inc. | Bronchoscopic lung volume reduction method |
US7497857B2 (en) | 2003-04-29 | 2009-03-03 | Medtronic, Inc. | Endocardial dispersive electrode for use with a monopolar RF ablation pen |
US7200559B2 (en) * | 2003-05-29 | 2007-04-03 | Microsoft Corporation | Semantic object synchronous understanding implemented with speech application language tags |
US7533667B2 (en) | 2003-05-29 | 2009-05-19 | Portaero, Inc. | Methods and devices to assist pulmonary decompression |
US7533671B2 (en) | 2003-08-08 | 2009-05-19 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US8206684B2 (en) | 2004-02-27 | 2012-06-26 | Pulmonx Corporation | Methods and devices for blocking flow through collateral pathways in the lung |
US7645285B2 (en) | 2004-05-26 | 2010-01-12 | Idx Medical, Ltd | Apparatus and methods for occluding a hollow anatomical structure |
US7549984B2 (en) | 2004-06-16 | 2009-06-23 | Pneumrx, Inc. | Method of compressing a portion of a lung |
US8409219B2 (en) | 2004-06-18 | 2013-04-02 | Medtronic, Inc. | Method and system for placement of electrical lead inside heart |
US7771472B2 (en) | 2004-11-19 | 2010-08-10 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
US7398782B2 (en) | 2004-11-19 | 2008-07-15 | Portaero, Inc. | Method for pulmonary drug delivery |
US8876791B2 (en) | 2005-02-25 | 2014-11-04 | Pulmonx Corporation | Collateral pathway treatment using agent entrained by aspiration flow current |
EP1906842B1 (en) | 2005-07-14 | 2016-12-21 | IDX Medical, Ltd. | Apparatus for occluding a hollow anatomical structure |
US8157818B2 (en) | 2005-08-01 | 2012-04-17 | Ension, Inc. | Integrated medical apparatus for non-traumatic grasping, manipulating and closure of tissue |
US20070208217A1 (en) | 2006-03-03 | 2007-09-06 | Acorn Cardiovascular, Inc. | Self-adjusting attachment structure for a cardiac support device |
US7691151B2 (en) | 2006-03-31 | 2010-04-06 | Spiration, Inc. | Articulable Anchor |
US7829986B2 (en) * | 2006-04-01 | 2010-11-09 | Stats Chippac Ltd. | Integrated circuit package system with net spacer |
US20080243141A1 (en) | 2007-04-02 | 2008-10-02 | Salvatore Privitera | Surgical instrument with separate tool head and method of use |
US8728093B2 (en) * | 2007-09-18 | 2014-05-20 | Boston Scientific Scimed, Inc. | Compression, banding and percutaneous airway ligation of emphysematous lung tissue |
US8043301B2 (en) | 2007-10-12 | 2011-10-25 | Spiration, Inc. | Valve loader method, system, and apparatus |
JP5570993B2 (en) | 2007-10-12 | 2014-08-13 | スピレーション インコーポレイテッド | Valve loader methods, systems, and apparatus |
US9393023B2 (en) | 2009-01-13 | 2016-07-19 | Atricure, Inc. | Apparatus and methods for deploying a clip to occlude an anatomical structure |
AU2010276239B2 (en) * | 2009-07-21 | 2015-08-06 | Applied Medical Resources Corporation | Surgical access device comprising internal retractor |
US9017349B2 (en) | 2010-10-27 | 2015-04-28 | Atricure, Inc. | Appendage clamp deployment assist device |
US9066741B2 (en) | 2010-11-01 | 2015-06-30 | Atricure, Inc. | Robotic toolkit |
US8636754B2 (en) | 2010-11-11 | 2014-01-28 | Atricure, Inc. | Clip applicator |
US8795241B2 (en) | 2011-05-13 | 2014-08-05 | Spiration, Inc. | Deployment catheter |
CA3099578C (en) | 2011-08-15 | 2023-10-03 | Atricure Inc. | Surgical device |
EP2758010B1 (en) | 2011-09-23 | 2017-02-08 | Pulmonx, Inc | Implant loading system |
EP2599461A1 (en) * | 2011-12-02 | 2013-06-05 | Rainer Zotz | A device for performing diagnostics and/or therapy |
CN104271075B (en) | 2011-12-02 | 2015-12-02 | 雷内·佐兹 | A kind of equipment for performing diagnosis and/or treatment |
US9282973B2 (en) | 2012-01-20 | 2016-03-15 | Atricure, Inc. | Clip deployment tool and associated methods |
AU2013328871B2 (en) | 2012-10-12 | 2018-08-16 | Diaxamed, Llc | Cardiac treatment system and method |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1284108B1 (en) | 1996-07-04 | 1998-05-08 | Carlo Rebuffat | SURGICAL PRESIDIUM FOR THE TREATMENT OF PULMONARY EMPHYSEMA |
US5702343A (en) * | 1996-10-02 | 1997-12-30 | Acorn Medical, Inc. | Cardiac reinforcement device |
US6241654B1 (en) * | 1999-07-07 | 2001-06-05 | Acorn Cardiovasculr, Inc. | Cardiac reinforcement devices and methods |
-
1999
- 1999-08-24 US US09/379,973 patent/US6416554B1/en not_active Expired - Lifetime
-
2000
- 2000-08-23 CA CA002316707A patent/CA2316707C/en not_active Expired - Fee Related
- 2000-08-24 AU AU53611/00A patent/AU772041B2/en not_active Ceased
-
2002
- 2002-07-18 US US10/199,776 patent/US20020188171A1/en not_active Abandoned
Cited By (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6997189B2 (en) | 1998-06-05 | 2006-02-14 | Broncus Technologies, Inc. | Method for lung volume reduction |
US20040078054A1 (en) * | 1998-06-05 | 2004-04-22 | Broncus Technologies, Inc. | Method for lung volume reduction |
US7828789B2 (en) | 2003-05-07 | 2010-11-09 | Portaero, Inc. | Device and method for creating a localized pleurodesis and treating a lung through the localized pleurodesis |
US8029492B2 (en) | 2003-05-07 | 2011-10-04 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
US7811274B2 (en) | 2003-05-07 | 2010-10-12 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
US7789083B2 (en) | 2003-05-20 | 2010-09-07 | Portaero, Inc. | Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease |
US7896008B2 (en) | 2003-06-03 | 2011-03-01 | Portaero, Inc. | Lung reduction system |
US7753052B2 (en) | 2003-06-05 | 2010-07-13 | Portaero, Inc. | Intra-thoracic collateral ventilation bypass system |
US7682332B2 (en) | 2003-07-15 | 2010-03-23 | Portaero, Inc. | Methods to accelerate wound healing in thoracic anastomosis applications |
US8323230B2 (en) | 2003-07-15 | 2012-12-04 | Portaero, Inc. | Methods and devices to accelerate wound healing in thoracic anastomosis applications |
US7775968B2 (en) | 2004-06-14 | 2010-08-17 | Pneumrx, Inc. | Guided access to lung tissues |
US7670282B2 (en) | 2004-06-14 | 2010-03-02 | Pneumrx, Inc. | Lung access device |
US7766891B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Lung device with sealing features |
US7766938B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
US8220460B2 (en) | 2004-11-19 | 2012-07-17 | Portaero, Inc. | Evacuation device and method for creating a localized pleurodesis |
US10034999B2 (en) | 2004-11-23 | 2018-07-31 | Pneumrx, Inc. | Steerable device for accessing a target site and methods |
US9125639B2 (en) | 2004-11-23 | 2015-09-08 | Pneumrx, Inc. | Steerable device for accessing a target site and methods |
US7824366B2 (en) | 2004-12-10 | 2010-11-02 | Portaero, Inc. | Collateral ventilation device with chest tube/evacuation features and method |
US8104474B2 (en) | 2005-08-23 | 2012-01-31 | Portaero, Inc. | Collateral ventilation bypass system with retention features |
US7726305B2 (en) | 2006-01-17 | 2010-06-01 | Portaero, Inc. | Variable resistance pulmonary ventilation bypass valve |
US7686013B2 (en) | 2006-01-17 | 2010-03-30 | Portaero, Inc. | Variable resistance pulmonary ventilation bypass valve |
US9782558B2 (en) | 2006-03-13 | 2017-10-10 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US8157837B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US10188397B2 (en) | 2006-03-13 | 2019-01-29 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US9474533B2 (en) | 2006-03-13 | 2016-10-25 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US8282660B2 (en) | 2006-03-13 | 2012-10-09 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US10226257B2 (en) | 2006-03-13 | 2019-03-12 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8668707B2 (en) | 2006-03-13 | 2014-03-11 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8740921B2 (en) | 2006-03-13 | 2014-06-03 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8142455B2 (en) | 2006-03-13 | 2012-03-27 | Pneumrx, Inc. | Delivery of minimally invasive lung volume reduction devices |
US8157823B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US9402971B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US9402632B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8932310B2 (en) | 2006-03-13 | 2015-01-13 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US7931641B2 (en) | 2007-05-11 | 2011-04-26 | Portaero, Inc. | Visceral pleura ring connector |
US8163034B2 (en) | 2007-05-11 | 2012-04-24 | Portaero, Inc. | Methods and devices to create a chemically and/or mechanically localized pleurodesis |
US8062315B2 (en) * | 2007-05-17 | 2011-11-22 | Portaero, Inc. | Variable parietal/visceral pleural coupling |
US7909803B2 (en) | 2008-02-19 | 2011-03-22 | Portaero, Inc. | Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease |
US8252003B2 (en) | 2008-02-19 | 2012-08-28 | Portaero, Inc. | Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease |
US8474449B2 (en) | 2008-02-19 | 2013-07-02 | Portaero, Inc. | Variable length pneumostoma management system for treatment of chronic obstructive pulmonary disease |
US8491602B2 (en) | 2008-02-19 | 2013-07-23 | Portaero, Inc. | Single-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease |
US8506577B2 (en) | 2008-02-19 | 2013-08-13 | Portaero, Inc. | Two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease |
US7927324B2 (en) | 2008-02-19 | 2011-04-19 | Portaero, Inc. | Aspirator and method for pneumostoma management |
US8021320B2 (en) | 2008-02-19 | 2011-09-20 | Portaero, Inc. | Self-sealing device and method for delivery of a therapeutic agent through a pneumostoma |
US8464708B2 (en) | 2008-02-19 | 2013-06-18 | Portaero, Inc. | Pneumostoma management system having a cosmetic and/or protective cover |
US8231581B2 (en) | 2008-02-19 | 2012-07-31 | Portaero, Inc. | Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease |
US8453637B2 (en) | 2008-02-19 | 2013-06-04 | Portaero, Inc. | Pneumostoma management system for treatment of chronic obstructive pulmonary disease |
US8453638B2 (en) | 2008-02-19 | 2013-06-04 | Portaero, Inc. | One-piece pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease |
US8430094B2 (en) | 2008-02-19 | 2013-04-30 | Portaero, Inc. | Flexible pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease |
US8365722B2 (en) | 2008-02-19 | 2013-02-05 | Portaero, Inc. | Multi-layer pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease |
US8475389B2 (en) | 2008-02-19 | 2013-07-02 | Portaero, Inc. | Methods and devices for assessment of pneumostoma function |
US8336540B2 (en) | 2008-02-19 | 2012-12-25 | Portaero, Inc. | Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease |
US8347880B2 (en) | 2008-02-19 | 2013-01-08 | Potaero, Inc. | Pneumostoma management system with secretion management features for treatment of chronic obstructive pulmonary disease |
US8348906B2 (en) | 2008-02-19 | 2013-01-08 | Portaero, Inc. | Aspirator for pneumostoma management |
US9192403B2 (en) | 2008-09-12 | 2015-11-24 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US9173669B2 (en) | 2008-09-12 | 2015-11-03 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US10058331B2 (en) | 2008-09-12 | 2018-08-28 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US8632605B2 (en) | 2008-09-12 | 2014-01-21 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US10285707B2 (en) | 2008-09-12 | 2019-05-14 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US8347881B2 (en) | 2009-01-08 | 2013-01-08 | Portaero, Inc. | Pneumostoma management device with integrated patency sensor and method |
US8518053B2 (en) | 2009-02-11 | 2013-08-27 | Portaero, Inc. | Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease |
US8721734B2 (en) | 2009-05-18 | 2014-05-13 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
Also Published As
Publication number | Publication date |
---|---|
AU5361100A (en) | 2001-03-01 |
US6416554B1 (en) | 2002-07-09 |
CA2316707C (en) | 2008-01-08 |
AU772041B2 (en) | 2004-04-08 |
CA2316707A1 (en) | 2001-02-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6416554B1 (en) | Lung reduction apparatus and method | |
CA2380968C (en) | Lung reduction device, system, and method | |
EP1078601B1 (en) | Kit for lung volume reduction | |
US6402754B1 (en) | Apparatus for expanding the thorax | |
US7896887B2 (en) | Apparatus and method for deployment of a bronchial obstruction device | |
US8414655B2 (en) | Removable lung reduction devices, systems, and methods | |
US20020112729A1 (en) | Intra-bronchial obstructing device that controls biological interaction with the patient | |
US20030212412A1 (en) | Intra-bronchial obstructing device that permits mucus transport | |
US20060235432A1 (en) | Intra-bronchial obstructing device that controls biological interaction with the patient | |
AU2002349977A1 (en) | Bronchial obstruction device deployment system and method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: SPIRATION, INC., WASHINGTON Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ALFERNESS, CLIFTON A.;LIN, RICHARD Y.;JAEGER, WILFRED E.;REEL/FRAME:013319/0657;SIGNING DATES FROM 20020913 TO 20020915 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: GYRUS ACMI, INC., MASSACHUSETTS Free format text: MERGER;ASSIGNOR:SPIRATION, INC.;REEL/FRAME:052401/0484 Effective date: 20200401 |