US20040172140A1 - Tissue stabilizing implant - Google Patents
Tissue stabilizing implant Download PDFInfo
- Publication number
- US20040172140A1 US20040172140A1 US10/793,265 US79326504A US2004172140A1 US 20040172140 A1 US20040172140 A1 US 20040172140A1 US 79326504 A US79326504 A US 79326504A US 2004172140 A1 US2004172140 A1 US 2004172140A1
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- US
- United States
- Prior art keywords
- tissue
- implant
- graft
- retainer
- bone
- Prior art date
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
Description
- This application is a continuation of application Ser. No. 10/279,451, filed Oct. 24, 2002. The aforementioned application Ser. No. 10/279,451 is itself a continuation of application Ser. No. 09/798,870, filed Mar. 1, 2001, now U.S. Pat. No. 6,503,277 B2. The aforementioned application Ser. No. 09/798,870 is itself a continuation of application Ser. No. 09/602,743, filed Jun. 23, 2000, now U.S. Pat. No. 6,361,565. The aforementioned application Ser. No. 09/602,743 is a continuation of application Ser. No. 09/263,006, filed Mar. 5, 1999, now U.S. Pat. No. 6,132,472. The aforementioned application Ser. No. 09/263,006 is itself a continuation of application Ser. No. 08/834,028, filed Apr. 11, 1997, now U.S. Pat. No. 5,888,219. The aforementioned application Ser. No. 08/834,028 is itself a divisional of application Ser. No. 08/590,193, filed Jan. 23, 1996, now U.S. Pat. No. 5,662,710. The aforementioned application Ser. No. 08/590,193 is itself a divisional of application Ser. No. 08/273,028, filed Jul. 8, 1994, now U.S. Pat. No. 5,545,222. The aforementioned application Ser. No. 08/273,028 is itself a divisional of application Ser. No. 07/728,247, filed Aug. 12, 1991, now U.S. Pat. No. 5,329,846. The benefit of the earlier filing dates of the aforementioned applications and patents is claimed.
- Tissue grafting, including bone grafting, is well known. Tissue such as bone is removed from one part of a body (the donor site) and inserted into tissue in another (the host site) part of the same (or another) body. It is desirable to be able to remove a piece of tissue graft material which is the exact size and shape needed for the host site where it will be implanted. However, it is rarely possible to do this.
- Accordingly, various tissue grafting techniques have been tried to solve this problem. For example, U.S. Pat. No. 4,678,470, granted to Nashef, discloses a method of creating bone graft material by machining a block of bone to a particular shape, or by pulverizing and milling it. The graft material is then tanned with glutaraldehyde to sterilize it. This process can produce bone plugs of a desired shape.
- In the Nashef process, the exogenic bone material selected for the graft is presumably dead at the beginning of the process. The process of pulverizing or milling the bone material destroys the structure of the bone tissue. The step of tanning it with glutaraldehyde then renders the graft material completely sterile. This condition is not conducive to graft healing and ingrowth. Specifically, applicant has found that it is desirable to maintain graft tissue in a living state during the grafting process. The use of living tissue in a graft will promote bone healing.
- The present invention is a tissue press for shaping or compressing a piece of tissue. The press includes first and second members movable relative to each other. First and second forming elements of different predetermined shapes are positionable on the first and second members on opposite sides of the piece of tissue. The first and second members are moved toward each other to shape or compress the tissue between the first and second forming elements.
- Means are preferably provided for monitoring and controlling the amount of force or pressure applied to the piece of tissue, in order to maintain the tissue in a viable living condition. Means may also be provided for draining off fluid from compressed tissue, so that the tissue can be implanted in a compressed state and imbibe fluid from the host site.
- The present invention is also a method of reshaping tissue for use as graft material comprising the steps of determining the shape which the tissue should possess as graft material; providing a tissue press, selecting forming elements adapted to press tissue approximately to the desired shape, and placing the forming elements on the tissue press; placing the tissue in the tissue press between the forming elements; operating the tissue press to shape the tissue between the forming elements to give the tissue the desired shape; and controlling the pressure on the tissue during the shaping step to minimize damage to or necrosis of the tissue.
- The present invention is also a method which includes the steps of determining the shape and size which the tissue should possess as graft material; placing the tissue in a tissue press having forming elements adapted to press tissue approximately to the shape and size desired; compressing the tissue in the tissue press to give the tissue the shape and size desired; controlling the pressure on the tissue during the compressing step to minimize damage to or necrosis of the tissue; and draining off fluid expressed during the compressing step.
- In accordance with another feature of the present invention, a retainer is provided for retaining tissue graft material in its compressed state. The retainer is placed around the compressed graft. The retainer can help to maintain the graft in a compressed configuration or in a specific shape for a period of time long enough to be placed in the body. The retainer may be made of a material which expands after it is placed in the body, to mechanically interlock the graft to the body.
- With the apparatus and method of the present invention, bone or other tissue can be compressed or reshaped or both, while preserving the tissue alive.
- Often, reshaping of graft tissue is necessary to obtain the best possible graft. For example, in an anterior cruciate ligament reconstruction, the graft material which is removed usually has a triangular cross-sectional configuration. This graft material is placed in an opening in bone formed by drilling with a round drill. When the triangular graft material is placed in the round opening, there is minimal physical contact between the graft material and the surrounding bone. This reduces the holding power of the graft and also reduces the ingrowth ability of the graft.
- Thus, an important feature of the present invention is that bone or other tissue such as ligament is reshaped while still leaving it in a whole condition and without substantial tissue damage. The tissue is placed in the tissue press of the present invention and sufficient force is applied to reshape the tissue to the desired shape—for example, a cylindrical shape as needed for an anterior cruciate ligament reconstruction. Excessive pressure on the tissue, which can damage or kill the tissue, is avoided as described below. A properly shaped graft is thus provided which is still in a living condition.
- Compression of graft tissue is also sometimes desirable. Generally, tissue is stronger when it is denser. Compressing graft tissue increases its density and thus strengthens the graft tissue. The graft tissue also stays together better.
- For example, a tendon is made of a plurality of fibers. The individual fibers are weak when separated or unraveled. If a tendon graft is implanted with the fibers in a loose condition, the graft is weak. On the other hand, if prior to implantation the tendon graft is compressed to orient and pack the fibers tightly, then the entire group of fibers acts as one whole unit and the graft is much stronger. Therefore, compressing the tendon graft gives it more mechanical integrity—making a smaller tendon graft much stronger.
- Similarly, bone tissue is stronger and better able to bear force when it is denser and more compact. Compressing bone graft tissue prior to implantation produces a stronger graft. Compression of bone or other tissue also allows a surgeon to convert a larger irregular shape into a smaller specific shape. Thus, the surgeon when removing the graft material from the donor Site is not limited by the conditions at the host site but can remove the graft material in the best way possible from the donor site. Similarly, the surgeon when implanting the graft material at the host site is not limited by the shape of the material removed (as dictated by the conditions at the donor site) but can implant the graft material in the best way possible to fit the conditions at the host site.
- The anterior cruciate ligament, for example, attaches to the femur and tibia at specific isometric locations. When the ligament is being replaced in an anterior cruciate ligament reconstruction, typical uncompressed graft material can be many times the size of those locations. In such a case it is necessary to drill openings much larger than desired in the bone to attach the new ligament. The graft tendon then tends to fall eccentrically in this larger opening, the functional anatomy of the ligament can not be recreated, and the functioning of the knee joint is compromised.
- However, if the graft material for the new ligament is compressed in accordance with the present invention, its size can be reduced substantially. This allows the surgeon to drill a substantially smaller opening in the bone to attach the new ligament/graft structure, so as to recreate the functional anatomy of the ligament.
- With the present invention, it is also possible to make a composite graft. For example, the graft material for an anterior cruciate ligament reconstruction is preferably tendon in the middle with bone at both ends. In accordance with the apparatus and method of the present invention, bone tissue can be compressed around the ends of tendon tissue to form a substitute anterior cruciate ligament more closely approximating the original.
- It should also be noted that tissues other than bone and tendon can be worked with the tissue press. For example, a surgeon can harvest liver cells or pancreas cells and then compress them into a particular shape. They can then optionally be placed into a sack or some type of structural support which can be introduced into the body.
- With the present invention, graft material can be formed into almost any shape. A specific pair of forming (mold) parts, having a desired predetermined shape, are positioned on the tissue press, and the tissue is shaped or compressed between the forming elements. In addition to three-dimensional shaped parts, it is also possible to make a flat piece of graft material. For example, shaved skin can be placed on a flat plate, perhaps on a retaining mesh. The cells are then subjected to pressure to adhere them together. A flat, even, piece of graft material is formed which is suitable for skin grafting.
- Compressing graft material in accordance with the present invention also allows the surgeon to build up a larger piece of graft material out of several smaller parts. Sometimes a relatively large piece of graft material is needed for a particular host site. It is often not feasible to take such a large piece of graft material without damaging the donor area. To avoid this problem, several smaller pieces of graft material are placed in the tissue press and pressure is used to at least temporarily form the smaller parts together as one larger whole. The larger graft piece is then inserted into the host site.
- Compressing graft material in accordance with the present invention also aids in introducing additional materials to the graft material. These additional materials could be antibiotics, bone growth enhancers, tri-calcium phosphate, fibrin, allograft or autograft material, etc. When added to the graft material under pressure, the added materials adhere to and become a part of the graft material and not merely something added to the surface of it. By combining physiologic solutions or a carrier such as a gelatin, polysaccharides, antibiotics or synthetic bone materials to the compressed bone, for example, it is possible to create a plug of living bone with the other materials added into it. This plug has the graft properties of the bone tissue in the plug, as well as the properties of the added material.
- When tissue is compressed, fluid may be forced out of (expressed from) the tissue. If tissue in this compressed and defluidized state is laid back in a tissue pouch or in a bone hole, body fluids from the host site are absorbed by the graft material. This imbibition causes swelling of the graft material and thus creates a mechanical interlock between the graft and the host. Such a mechanical interlock is not produced with a typical implantation process in which graft tissue is not compressed. Further, the swelling (enlarging) of the graft material allows the graft material to fill an opening of any given shape with a perfect fit of the graft material therein.
- As noted above, applicant has found that it is desirable to maintain bone graft tissue in a living state during the grafting process. It is important not to kill tissue used in grafting because the living graft cells provide a superior substrate for grafting and graft viability and improved tissue healing. There is significantly faster incorporation of living tissue than of dead tissue. The cells and the tissue that are implanted into the body therefore need to be maintained in a viable condition.
- Excess pressure on tissue can cause destruction of the tissue, disorganization of the tissue fibers and irregular mechanical structure which can damage the tissue graft. Thus, a feature of the present invention is that the pressure or force on the tissue being reshaped or compressed is monitored and controlled. Pressure can be monitored by suitable pressure sensors and readouts such as a pressure gauge. Pressure can be controlled by force limiting means such as a torque wrench or similar device.
- The desired pressure levels may vary. For example, it may be desirable to provide a higher compressive force for cortical bone than for cancellous bone. Similarly, it may be desirable to provide a higher compressive force for bone than for tendon tissue. The appropriate level of pressure or force is selectively available with the tissue press.
- A separate device or structure can be used to maintain graft tissue in the compressed state prior to and during implantation. This separate device or structure can be a mesh sack, a ring around a cylindrically shaped graft material, etc. This additional retainer structure can assist the surgeon in introducing the graft tissue into the body in the compacted condition, to provide a denser stronger graft and to allow imbibition for creating a mechanical interlock. The retainer can be made of a material which expands when placed in the body, to provide a mechanical interlock for the graft tissue.
- The foregoing and other features of the present invention will become apparent to one skilled in the art upon a consideration of the following description of the invention with reference to the accompanying drawings, wherein:
- FIG. 1 is a top plan view of a tissue press embodying the present invention;
- FIG. 2 is a top plan view of a tissue press similar to the tissue press of FIG. 1 and having a pressure sensing and monitoring mechanism;
- FIG. 3 is an elevational view of the tissue press of FIG. 2;
- FIGS. 3A and 3B illustrate a tissue press having means for removing excess tissue after compression;
- FIGS. 4A-4F illustrate a plurality of different forming elements for use in the tissue press of FIGS. 1-3;
- FIG. 5 is a view of a tissue press in accordance with a second embodiment of the invention;
- FIG. 6 is a view of a tissue press in accordance with a third embodiment of the invention;
- FIG. 6A illustrates a tissue press having means for limiting the amount of pressure applied to the tissue;
- FIGS. 7 and 7A illustrate a composite tissue graft such as compression of bone around tendon;
- FIG. 8 is a view of a tissue press in accordance with a fourth embodiment of the invention illustrating extrusion of tissue graft material;
- FIGS. 9A-9F illustrate a plurality of different retainers for compressed tissue;
- FIGS. 10A and 10B illustrate an expanding tissue retainer;
- FIGS. 11, 11A and11B illustrate an expanding surgical implant; and
- FIGS. 12 and 12A illustrate expanding surgical stabilization devices.
- The present invention relates to a tissue press and particularly to a tissue press for shaping or compressing bone or other tissue. The present invention is applicable to various constructions of tissue shaping or compressing apparatus. As representative of the present invention, FIG. 1 illustrates a
tissue press 10. - The
tissue press 10 includes abase 12. Thebase 12 has asupport surface 14 for supporting thebase 10 and thus thepress 10 on a table or other support (not shown). Thebase 12 has the same longitudinal cross-section throughout its width as is seen in elevation in FIG. 1. Twocylindrical pins 16 protect upwardly from thebase 12. AU-shaped saddle 18 is secured to thebase 12 byscrews 20. Apin opening 22 extends transversely through thesaddle 18. - The
tissue press 10 also includes ahandle 30. Thehandle 30 has aconnector portion 32 received between the upwardly projecting side portions of thesaddle 18 of thebase 12. Apin opening 34 extends transversely through theconnector portion 32 of thehandle 30. Theopening 34 is aligned with theopening 22 in thesaddle 18. Apivot pin 36 extends through thepin openings handle 30 andbase 12, respectively, and pivotally connects thehandle 30 to thebase 12. - Extending from the
connector portion 32 of thehandle 30 is a form-supportingportion 40 of thehandle 30. Achannel 42 is defined on the lower side of the form-supportingportion 40 between a pair of channel surfaces 44. Thechannel 42 extends transversely across the width of the form-supportingportion 40. Extending from the form-supportingportion 40 is acircular portion 46 of thehandle 30. Thecircular portion 46 has a manuallyengageable surface 48 for the application of force to thehandle 30. - A first forming
element 50 is slidably received on thebase 12. The first formingelement 50 has two vertically extendingpin openings 52 which receive thepins 16 of thebase 12. The first formingelement 50 has anupper surface 54 which includes a formingsurface 56. The formingsurface 56 has acylindrical surface portion 58. The first formingelement 50 has the same longitudinal cross-section throughout its width as is seen in elevation in FIG. 1. It should be understood that the first formingelement 50 can be connected with the base 12 in any other suitable manner. - A second forming
element 60 is slidably received in thechannel 42 of thehandle 30. The second formingelement 60 has two projectingedges 62 which engage the channel surfaces 44 of thehandle 30. The second formingelement 60 has alower surface 64 which includes a formingsurface 66. The formingsurface 66 includes acylindrical surface portion 68. The second formingelement 60 has the same longitudinal cross-section throughout its width as is seen in elevation in FIG. 1. It should be understood that the second formingelement 60 can be connected with thehandle 30 in any other suitable manner. - In operation of the
press 10, a pair of formingelements tissue 70 to the desired shape. For example, the formingelements element 50 is slid onto thepins 16 on thebase 12. The second formingelement 60 is slid into thechannel 42 in thehandle 30. Aset screw 72 is tightened to secure the second formingelement 60 to thehandle 30. - The piece of
tissue 70 to be shaped is placed between the first and second formingelements tissue 70 is preferably positioned on the formingsurface 56 of the first formingelement 50 as illustrated in FIG. 1. Thehandle 30 is then brought toward the base 12 in the direction indicated by thearrow 74, by the application of force to thehandle 30. The formingsurface 66 with itscylindrical surface portion 68 engages thetissue 70, and forces thetissue 70 against the formingsurface 56 with itscylindrical surface portion 58. Thetissue 70 is thereby formed to the desired shape. - It should be understood that with the
tissue press 10, tissue can be reshaped only, or reshaped and compressed. The amount and type of work performed on the tissue depends on the particular application, and is controlled by (i) the particular forming elements selected by the operator of the tissue press, and (ii) the amount of pressure or force applied to the tissue. For example, the forming elements can be selected so that they define between them a forming chamber having the same initial volume as the piece of tissue to be shaped. In this case, the piece of tissue is not compressed (that is, reduced in volume), but is merely reshaped. Alternatively, forming elements can be selected which will not merely reshape the piece of tissue but also will compress it, as described above. Because the first and second formingelements base 12 and handle 30, respectively, the surgeon can easily select first and second formingelements tissue 70 as desired. - As discussed above, it is important to control the pressure on the tissue in the
tissue press 10. There are many ways to do this. For example, in thepress 80 shown in FIGS. 2 and 3, a second formingelement 84 has anopening 82 which extends between itsupper surface 86 and its formingsurface 88. Anopening 90 in thehandle 92 is aligned with and in fluid communication with theopening 82. A pressure monitor device indicated schematically at 94 is in fluid communication with theopening 90 in thehandle 92, and thus with the formingsurface 88 on the second formingelement 84. Thepressure monitor device 94 can be any known device for displaying pressure, such as a dial readout, a bar movable axially in theopenings pressure monitor device 94 displays the pressure at the formingsurface 88 of the second formingelement 84. This is the pressure applied to the tissue being pressed in thepress 80. Thus, an operator of thepress 80 can observe thispressure monitor device 94 and limit the applied force accordingly, in order to avoid tissue damage or necrosis. - Alternatively, a strain gauge of a known construction, indicated schematically at96, can be placed on the forming
surface 88 of the second formingelement 84. Electric wires (not shown) transmit signals from thestrain gauge 96 to an electric readout device indicated schematically at 94. The electric readout indicates electrically the pressure applied to the tissue in thepress 80. Again, one can observe this pressure monitor device and limit the amount of force applied, in order to avoid tissue damage or necrosis. It should be understood that similar ways of monitoring the pressure on the tissue being pressed are the equivalent and are thus included within the scope of the invention. - Any of the tissue presses of the present invention can include means for cutting off excess tissue. As an example, FIGS. 3A and 3B illustrate a
tissue press 91 having anindependent cutoff arm 93 pivotally mounted adjacent thehandle 95. Thecutoff arm 93 has ablade portion 97 operable to cut off excess tissue compressed by thetissue press 91. Thecutoff arm 93 is, of course, merely illustrative of the many equivalent structures usable to remove excess tissue after the compressing or shaping operation. Thus, the length of the tissue graft material, as well as its compressed diameter, can be selectively controlled by operation of the tissue press. It should be noted that this cutting off process can be affected with the edges of the forming elements themselves, as illustrated in the apparatus in FIG. 5. - As noted above, the first forming
element 50 and the second formingelement 60 are removably received on thebase 12 and handle 30, respectively. Thus, forming elements having forming surfaces with other shapes can be easily placed in thetissue press 10, in order to shape or compress tissue into other shapes. A few of the many shapes obtainable are illustrated in FIG. 4. - FIG. 4A, for example, illustrates the forming
elements elements surface 104 on the first formingelement 100 and a formingsurface 106 on the second formingelement 102. FIG. 4C illustrates formingelements surface 112 on the first formingelement 108 and a formingsurface 114 on the second formingelement 110. - FIG. 4D illustrates forming
elements surface 120 on the first formingelement 116 and a formingsurface 122 on the second formingelement 118. FIG. 4E illustrates formingelements surface 128 on the first formingelement 124 and a formingsurface 130 on the second formingelement 126. FIG. 4F illustrates formingelements surface 136 on the first formingelement 132 and a formingsurface 138 on the second formingelement 134. Again, it should be understood that other shapes are conceivable and consequently are included within the scope of the invention. - In addition to three-dimensional shaped parts, it is also possible to make a flat piece of graft material. Forming elements like those shown in FIG. 4E are useful in this case. For example, a skin graft may be placed on an adhesive based mesh (possibly using fibrin) on the flat forming
surface 128. The cells are then subjected to pressure to adhere them together. The cells are spread out over a finer layer. A flat, even, piece of skin graft material is formed. This can then be cut or pressed or formed into a specific shape and then used as a skin substitute on the body. - Any forming element useful in the present invention can be coated with a non-stick coating to reduce adhesion of the compressed tissue to the forming elements. For example, the forming element100 (FIG. 4B) is indicated as having a
non-stick coating 105 such as a Teflon™. coating which may be applied in any suitable known manner. Such a coating can resist the binding of the tissue (or tissue additive such as fibrin discussed below) to the formingelement 100. In a second embodiment of the invention, illustrated in FIG. 5, atissue press 150 is fluid operated (pneumatic or hydraulic) rather than manually operated. Thepress 150 includes a base 152 having asupport surface 154 for supporting thebase 152 and thus thepress 150 on a table 15 or other support (not shown). A first formingelement 156 is attached to thebase 152. The first formingelement 156 may be slidably or otherwise attached to the base 152 in any suitable manner which blocks movement of the formingelement 156 relative to the base 152 during operation of 20 thepress 150 and which allows for easy interchange of formingelements 156. The first formingelement 156 has an upwardly facing formingsurface 158. Afluid drain opening 160 is in fluid communication with the formingsurface 158 of the first formingelement 156. - An air or
hydraulic cylinder 170 is fixed to thebase 152 above the first formingelement 156. Thecylinder 170 has aport 172 for the introduction of air or other fluid under pressure to operate apiston 174 in a known manner. A second formingelement 180 is connected to thepiston 174. The second formingelement 180 is attached to thepiston 174 in any suitable manner which blocks movement of the formingelement 180 relative to thepiston 174 during operation of thepress 150 and which allows for easy interchange of formingelements 180. The second formingelement 180 has a formingsurface 182 facing the formingsurface 158 on the first formingelement 156. - A
port 176 in thecylinder 170 is in fluid communication with the formingsurface 182 of the second formingelement 180. Connected to theport 176 is a pressure monitor device shown schematically at 178. - In operation of the
press 150, a pair of formingelements element 156 is attached to thebase 152. The second formingelement 180 is attached to thepiston 174. A piece of tissue to be shaped (not shown) is placed between the first and second formingelements surface 158 of the first formingelement 156. - The
cylinder 170 is then actuated to move the second formingelement 180 toward the first formingelement 156. The formingsurface 182 on the second formingelement 180 engages the tissue, and forces the tissue against the formingsurface 158 on the first formingelement 156. Pressure on the tissue is controlled through observation of themonitor device 178. The tissue is formed to the desired shape. Again, it should be understood that with thepress 150 tissue can be reshaped only, or compressed also, depending on the application, the forming elements selected, and the amount of force applied. - As discussed above, when tissue is compressed, fluid may be expressed from the tissue. In the
press 150, the second formingelement 180 fits within the first formingelement 156 to define between them a closed forming chamber in which the tissue is compressed. Expressed fluid is drained from the forming chamber through thefluid drain opening 160. If a closed forming chamber is not formed, as for example with the open-ended forming elements shown in FIG. 1-4, then expressed fluid can drain outwardly from the tissue being pressed, without the need for a separate fluid drain port. Of course, a separate fluid drain port could be provided in any of the forming elements of the present invention. - In a third embodiment of the invention, illustrated in FIG. 6, a
tissue press 200 includes a base 202 having asupport surface 204 for supporting thebase 202 and thus thepress 200 on a table or other support (not shown). A first formingelement 206 is attached to thebase 202. The first formingelement 206 may be slidably or otherwise attached to the base 202 in any suitable manner. The first formingelement 206 includes a plurality offirst fingers 208 which together have a formingsurface 210 to progressively compress bone or other tissue into a predetermined shape. - An
upper arm 220 is pivotally mounted to thebase 202 by apivot pin 222. A second formingelement 224 is connected to theupper arm 220 in a suitable manner. The second formingelement 224 includes a plurality ofsecond fingers 226 which together have a formingsurface 228 facing the formingsurface 210 on the first formingelement 206. Thesecond fingers 226 are interdigitable with thefirst fingers 208. - In operation of the
press 200, a pair of formingelements element 206 is attached to thebase 202. The second formingelement 224 is attached to theupper arm 220. A piece of tissue to be shaped (not shown) is placed between the first and second formingelements surface 210 of the first formingelement 206. The upper arm is pivoted toward the base to move the second formingelement 224 toward the first formingelement 206. The formingsurface 228 on the second formingelement 224 engages the tissue, and forces the tissue against the formingsurface 210 on the first formingelement 206. The tissue is formed to the desired shape. - Because the
second fingers 226 are interdigitable with thefirst fingers 208, thepress 200 is operable to compress tissue to different compressed sizes with only one pair of forming elements. As thesecond fingers 226 come together with thefirst fingers 208, they compress the tissue to a smaller and smaller diameter (shape). This allows for one pair of forming elements to provide compression to variable diameters or sizes. This works well with soft tissue applications, specifically tendons, to compress the tendon into a smaller shape. The amount of compression is based on the amount of pressure applied and the needed finished size. - As noted above, it is important to control the pressure or force applied to the tissue by the tissue press. Accordingly, the present invention provides means for limiting the amount of pressure applied to the tissue by the tissue press, that is, means for blocking application to the tissue of force in excess of a predetermined amount. Such means are schematically illustrated in FIG. 6A, which illustrates a
tissue press 300 having a known torque wrench assembly included therein. - The
press 300 includes abase 302. Attached to the base in the manner described above is a first formingpart 304. Also attached to the base is asaddle 306. Received in thesaddle 306 is theconnector portion 308 of ahandle assembly 310. Thepress 300 also includes apivot pin 312 pivotally interconnecting thehandle assembly 310 and thebase 302. - The
handle assembly 310 includes a form-supportingportion 314 to which there is attached in the manner described above a second formingpart 316. Thehandle assembly 310 also includes a second portion 318 connected to the form-supportingportion 314 by adrive mechanism 320. The second portion 318 includes aknurled section 322 which is rotatable about anaxis 324. On the second portion 318 there is agauge 326. - The
knurled section 322 is rotatable about theaxis 324 to set the torque value desired and as shown on thegauge 326. Thereafter, thehandle assembly 310 can be pivoted toward the base 302 in the direction indicated by thearrow 328 only until the preset amount of torque is applied. At that point, no more torque is transferred through thedrive mechanism 320 to the form-supportingportion 314. This limits the amount of pressure applied to the tissue by the second formingpart 316, that is, blocks application to the tissue of force in excess of a predetermined amount. - It should be understood that the torque wrench assembly or construction indicated in FIG. 6A is only illustrative of the many ways in which the amount of pressure applied to the tissue by the tissue press can be limited to a predetermined amount. There are other known mechanisms for performing the same function, and their use is included within the scope of the present invention.
- FIGS. 7 and 7A illustrate the use of a tissue press in accordance with the present invention to form a composite graft. As discussed above, with the present invention, it is also possible to make a composite graft. For example, the graft material for an anterior cruciate ligament reconstruction is preferably tendon in the middle with bone at both ends. In accordance with the apparatus and method of the present invention, bone tissue can be compressed around the ends of tendon tissue to form a substitute anterior cruciate ligament more closely approximating the original.
- Thus, as illustrated schematically in FIGS. 7 and 7A, the
tissue press 10 of FIG. 1-4 is being used to compressbone tissue 240 aroundtendon tissue 242 to form a substitute anteriorcruciate ligament 244. Thetendon 242 can be harvested from one site and thebone 240 can be harvested from another site. - It should be understood that the graft can be multiple tissue fragments rather than a composite material. Thus, the
tissue press 10, or indeed any tissue press in accordance with the present invention, can be used to compress, for example, multiple bone fragments into one larger piece. It should also be understood that the tissue press in accordance with the present invention can be used to add additional materials to body tissue material by pressure. For example, to bone tissue there can be added tri-calcium phosphate, an antibiotic, hydroxyapatite, allografts or autografts, or any other polymeric. This process is believed to be self-explanatory in light of the foregoing description, but for reference may be understood by referring to FIGS. 7 and 7A wherein 240 would be the bone tissue or other tissue to which material is being added (squeezed in under pressure), and 242 indicates the additional material being added to thetissue 240. - In this case, fibrin can be highly suitable for use as such an additional material. Fibrin is a blood component important in blood clotting. It can be separated or centrifuged from blood and has the nature of an adhesive gel. Fibrin can be used as an adhesive, either in a natural state or after being compressed, to hold together material such as separate tissue pieces pressed together in a tissue press of the present invention.
- In a fourth embodiment of the invention, illustrated in FIG. 8, a
tissue press 250 is operated to extrude rather than press material. Thepress 250 includes a base 252 having asupport surface 254 for supporting thebase 252 and thus thepress 250 on a table or other support (not shown). Adie 256 is attached to thebase 252. Thedie 256 may be slidably or otherwise attached to the base 252 in any suitable manner which blocks movement of thedie 256 relative to the base 252 during operation of thepress 250 and which allows for easy interchange of formingelements 256. Thedie 256 has an upwardly facingopening 258. Anextrusion opening 260 is in fluid communication with theopening 258 of thedie 256. - An air or
hydraulic cylinder 270 is fixed to thebase 252 above thedie 156. Thecylinder 270 has aport 272 for the introduction of air or other fluid under pressure to operate apiston 274 in a known manner. Aram 280 is connected to thepiston 274. Theram 280 has asurface 282 facing theopening 258 on thedie 256. - In operation of the
press 250, adie 256 is selected which will extrude tissue in the desired shape. Thedie 256 is attached to thebase 252. A piece of tissue to be extruded (not shown) is placed in theopening 258 of thedie 256. Thecylinder 270 is then actuated to move theram 280 toward thedie 256. Thesurface 282 on theram 280 engages the tissue, and forces the tissue into and through thedie 256, exiting through theopening 260. The tissue is extruded in the desired shape. As discussed above, a fluid drain port can be provided in thepress 250. - It can also be useful to heat or cool the tissue being worked in a tissue press of the present invention. Accordingly, the present invention contemplates the use of means for selectively controlling the temperature of the piece of tissue while it is being compressed or shaped. As an example, illustrated schematically in FIG. 4 is a
fluid passage 284 extending from the outer surface of the formingelement 124 and around the formingsurface 128 thereof. Fluid which is either heated or cooled flows through thepassage 284 and either cools or heats the material of the formingelement 124 in the area adjacent the formingsurface 128. Thus, the tissue, when it comes in contact with the formingsurface 128, can be selectively heated or cooled during the compression or reshaping operation. Heating can be useful in holding together materials being compressed, for example, and cooling can be useful to avoid tissue damage arising from overheating of tissue being compressed. It should be understood that other means of achieving these functions are contemplated, such as electrical heating elements. Further, both forming elements can be heated or cooled rather than just one. Any such equivalent structure is to be considered within the scope of the present invention. - Also in the present invention, a retainer is provided for retaining tissue graft material in its compressed state. After the graft is compressed, the retainer is placed around the graft. The retainer can help to maintain the graft in a compressed configuration or in a specific shape for a period of time long enough to be placed in the body.
- The retainer may be one of many different shapes. The shape of the retainer is chosen to meet the specific application. There are a number of suitable shapes, such as a ring, a cylinder, a cage, a rectangular shape, a mesh, a suture-like wrap, etc. Some of these are illustrated schematically in FIG. 9A-9F. It should be understood that this is not an exhaustive listing, but rather that these are merely exemplary of the principle involved, and accordingly, the invention is not limited to these particular shapes. For example, a retainer may be provided which is in the particular shape of the tissue material being compressed, which can be rectangular, cylindrical, planar, etc.
- FIG. 9A illustrates a plurality of bands or rings290 used to hold together compressed
tissue 292. FIG. 9B illustrates acage 294 which can be used to hold together thecompressed tissue 292 of FIG. 9A. Thecage 294 includes a plurality of crossedfilaments 296 which define between them a series ofopenings 298 for tissue ingrowth. FIG. 9C illustrates anothercage 300 which can be used to hold together thecompressed tissue 292 of FIG. 9A. Thecage 300 includes a plurality of longitudinally extendingfilaments 302 which define between them a series ofopenings 304 for tissue ingrowth. FIG. 9D illustrates a solid-walled cylinder 306 which can be used to hold together thecompressed tissue 292. FIG. 9E illustrates amesh cylinder 308 which can be used to hold together thecompressed tissue 292. FIG. 9F illustrates the wrapping of a cord orsuture 310 aroundcompressed tissue 312. - Any of these retainers may be made of various materials. The material of the retainer is chosen to meet the specific application. Some of the many materials which are suitable are biodegradable materials, ceramics (especially with bone-growth enhancers, hydroxyapatite, etc.); polymeric material such as Dacron® or other known surgical plastics; metal; or composite materials.
- In use, the graft material may be pushed into the retainer structure after graft material is compressed. Alternatively, the graft material may be compressed with the retainer structure. After the graft material is compressed in the retainer, the combined structure of graft plus retainer is placed in the host site in the body. The retainer helps to maintain the graft in a compressed configuration or in the specific shape into which it was compressed for a period of time long enough to be placed in the body.
- If the retainer is made of a biodegradable material, then the retainer degrades and disappears after a period of time. If the retainer is not made of a biodegradable material, then the retainer remains in the body. Tissue ingrowth occurs to bind the host tissue to the graft material. Tissue ingrowth through and around the retainer, between the host tissue and the graft material, is promoted if there are openings as discussed above in the retainer.
- The invention, the retainer may, if desired, be made of a material which expands after it is placed in the body, to mechanically interlock the graft to the body. The expansion can take place in one of two ways. First, the retainer can itself be compressed, as with the tissue, and then expand when placed in the body. Second, the retainer can be made of a material which expands when it comes in contact with water or other bodily fluids. (It should be noted that the tissue can itself be compressed then expand when contacted by water. As an example, a tendon can be compressed in a desiccated state, and as it imbibes water it expands and creates a firmer lock or tighter fit in the host site.)
- The expandable material can first be compressed with the tissue being grafted, and which then expands when placed in the body. The retainer is preferably made of a material which has more structural stability than the tissue being grafted, and provides mechanical integrity and structural support for the graft tissue. A retainer made of a solid polymeric material, for example, is useful to retain in a compressed state a tendon or bone tissue graft.
- These expandable materials can be used not only to retain graft material, but for any shape required for stabilization surgery, such as a wedge, screw, rivet, retaining ring, or spacer, an intramedullary rod, a joint replacement part such as a femoral component of acetabular cup, an expandable sleeve, or another mechanical structure. The expandable materials thus can be used both as a carrier or retainer for another material (e.g. tissue graft material) and on their own as a prosthetic element.
- There are a number of suitable materials which expand when they come in contact with water or other fluids. One is PEEK (polyether-etherketone). A desiccated biodegradable material, or a desiccated allograft may also be used.
- As a simple example, an expandable retainer330 (FIG. 10B) with
graft tissue 332 therein is placed into a tissue orbone space 334 defined by anedge 336 in host tissue 38. As theretainer 330 imbibes body fluids or water from thehost tissue 338, it expands radially outwardly into the tissue orbone space 334 and creates a mechanical interlock (FIG. 10A). It also expands radially inwardly and clamps on thegraft tissue 332. Therefore, thegraft tissue 332 is locked into the host site, without the necessity of damaging the tissue further through some other kind of attachment means. - For example, a hip replacement (femoral head) is typically made of metal. To implant the replacement, the softer, inner cancellous bone of the femur is first removed. The inner surface of the cortical bone is then machined to provide a close fit between the external surface of the replacement and the hard outer cortical bone material. All this requires a substantial opening in the femur and still does not guarantee a close enough fit for the implant.
- If, instead, the implant is made of an expanding material such as PEEK, only a smaller opening is needed, thus reducing trauma to the bone. Although it is best to lock against the cortical bone, it is possible to implant solely in the cancellous bone, which because of the expansion of the implant provides a better fit than a metal implant. A benefit of implanting in the cancellous bone is reduction of the danger of putting the implant in so tightly that the cortical bone is split (wedged open). Further, if the opening in the bone is not exactly the same shape as the outer surface of the implant, the implant expands to provide a custom contoured fit to the bone and provide immediate mechanical stability. Thus, less machining of the bone is needed, while at the same time obtaining a closer fit.
- Thus, as illustrated in FIG. 11-11B, a hip replacement (femoral head)340 is made of PEEK or another expandable material. The
replacement 340 is inserted into anintramedullary channel 342 cut into afemur 344. Thereplacement 340 is smaller in diameter than thechannel 342. Thereplacement 340 absorbs body fluids and expands to lock itself into thechannel 342 in thefemur 344. (It should be understood that the scale shown in FIG. 11-11B is exaggerated as to the amount by which thereplacement 340 expands.) - Similarly, a bone plate or other structure or tissue can be secured to a bone with a fastener made of such an expandable material. As illustrated schematically in FIGS. 12 and 12A, a
bone plate 350 is secured to abone 352. In FIG. 12, afastener 354 is used which has an unthreadedportion 356 extending into thebone 352. Thefastener 354, or at least theunthreaded portion 356, is made of PEEK or another suitable expandable material. Theportion 356 imbibes fluid from thebone 352 and expands radially outwardly, from an unexpanded condition as shown in phantom at 358 to an expanded condition as shown in solid lines at 360, to lock thefastener 354 into thebone 352. This enables the securing of theplate 350 to thebone 352 without cutting threads into thebone 352 as is usually done. - In FIG. 12A, a
fastener 362 has a threadedportion 364 extending into thebone 352. The threadedportion 364 is made of PEEK or another suitable expandable material. The threadedportion 364 imbibes fluid from thebone 352 and expands radially outwardly to additionally lock thefastener 362 into thebone 352. Alternatively, thefastener 362 of FIG. 12A may have acoating 366 on its portion threaded into thebone 352. Thecoating 366 is made of PEEK or another suitable expandable material. Thecoating 366 imbibes fluid from thebone 352 and expands radially outwardly to additionally lock the fastener into thebone 352. - When such a fastener is made of a non-metal expandable material, removal of the fastener simply entails drilling out the center thereof. This is much easier than with a typical metal bone screw.
- From the above description of the invention, those skilled in the art will perceive improvements, changes and modifications. Such improvements, changes and modifications within the skill of the art are intended to be covered by the appended claims.
Claims (23)
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US08/273,028 US5545222A (en) | 1991-08-12 | 1994-07-08 | Method using human tissue |
US08/590,193 US5662710A (en) | 1991-08-12 | 1996-01-23 | Tissue press method of use |
US08/834,028 US5888219A (en) | 1991-08-12 | 1997-04-11 | Method of using human tissue with a tissue press and system |
US09/263,006 US6132472A (en) | 1991-08-12 | 1999-03-05 | Tissue press and system |
US09/602,743 US6361565B1 (en) | 1991-08-12 | 2000-06-23 | Expandable hip implant |
US09/798,870 US6503277B2 (en) | 1991-08-12 | 2001-03-01 | Method of transplanting human body tissue |
US10/279,451 US6905517B2 (en) | 1991-08-12 | 2002-10-24 | Tissue grafting material |
US10/793,265 US7727283B2 (en) | 1991-08-12 | 2004-03-04 | Tissue stabilizing implant method |
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US10/279,451 Expired - Fee Related US6905517B2 (en) | 1991-08-12 | 2002-10-24 | Tissue grafting material |
US10/279,402 Expired - Fee Related US6860904B2 (en) | 1991-08-12 | 2002-10-24 | Method for tissue grafting |
US10/372,065 Expired - Fee Related US6776938B2 (en) | 1991-08-12 | 2003-02-21 | Method for forming implant containing tissue |
US10/371,265 Expired - Fee Related US6989029B2 (en) | 1991-08-12 | 2003-02-21 | Tissue cage |
US10/793,266 Abandoned US20040172033A1 (en) | 1991-08-12 | 2004-03-04 | Tissue stabilization device and method |
US10/793,265 Expired - Fee Related US7727283B2 (en) | 1991-08-12 | 2004-03-04 | Tissue stabilizing implant method |
US10/793,287 Expired - Fee Related US7070557B2 (en) | 1991-08-12 | 2004-03-04 | Tissue graft material and method of making |
US11/286,607 Expired - Fee Related US7462200B2 (en) | 1991-08-12 | 2005-11-23 | Method for tissue grafting |
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US09/871,936 Expired - Fee Related US6638309B2 (en) | 1991-08-12 | 2001-06-01 | Method of using body tissue |
US10/279,451 Expired - Fee Related US6905517B2 (en) | 1991-08-12 | 2002-10-24 | Tissue grafting material |
US10/279,402 Expired - Fee Related US6860904B2 (en) | 1991-08-12 | 2002-10-24 | Method for tissue grafting |
US10/372,065 Expired - Fee Related US6776938B2 (en) | 1991-08-12 | 2003-02-21 | Method for forming implant containing tissue |
US10/371,265 Expired - Fee Related US6989029B2 (en) | 1991-08-12 | 2003-02-21 | Tissue cage |
US10/793,266 Abandoned US20040172033A1 (en) | 1991-08-12 | 2004-03-04 | Tissue stabilization device and method |
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Also Published As
Publication number | Publication date |
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US6776938B2 (en) | 2004-08-17 |
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