US20040249363A1 - Implantable, refillable infusion device and septum replacement kit - Google Patents
Implantable, refillable infusion device and septum replacement kit Download PDFInfo
- Publication number
- US20040249363A1 US20040249363A1 US10/869,978 US86997804A US2004249363A1 US 20040249363 A1 US20040249363 A1 US 20040249363A1 US 86997804 A US86997804 A US 86997804A US 2004249363 A1 US2004249363 A1 US 2004249363A1
- Authority
- US
- United States
- Prior art keywords
- housing
- bellows
- infusion device
- fluid
- implantable infusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/14586—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/14586—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
- A61M5/14593—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm the diaphragm being actuated by fluid pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/04—Tools for specific apparatus
- A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
Definitions
- the invention relates to implantable infusion devices for controllable in vivo delivery of drugs to a patient.
- Implantable infusion devices provide a patient with an in vivo source of a drug to be administered, in a device which permits controlled delivery of the drug over a predetermined time period.
- Certain drugs such as, for example, chemotherapy drugs and opioids, may be most effective if administered at a constant dose rate, instead of at discrete intervals.
- a typical infusion device or pump includes a hermetically sealed outer housing which holds a vapor pressure fluid or other means for exerting a compressive force on a compressible or flexible inner drug reservoir which communicates with a drug delivery port.
- the drug may be disposed in the outer housing, with a propellant disposed in the inner housing.
- the outer housing When the outer housing is filled with the drug, the propellant in the inner housing is compressed and changes state from a vapor to a liquid, thereby recharging the driving mechanism of the device.
- the outer housing may be divided into two chambers separated by a liquid-impermeable diaphragm. One chamber contains the drug and includes a drug delivery port, and the other chamber contains a propellant or spring member for exerting a force against the diaphragm so as to expel the drug through the delivery port.
- the infusion device must meet numerous requirements for safety and efficacy.
- the housing material must not react with body fluids or with the drugs and propellants inside the housing.
- the membrane or flexible barrier between the chambers must not leak and must be impermeable to gas-phase fluids so as to prevent contamination of the drug with the propellant. Since the device is designed for implantation into a patient, great care must be taken to prevent any leakage of either the drug or the propellant into the patient's body.
- the device is desirably as small and lightweight as possible so as to cause minimum invasive trauma, discomfort and disfigurement to the patient, yet sufficiently large to provide a useful therapeutic dosage of the drug being administered and minimize the frequency with which the device must be recharged.
- Administration of a desired dosage of a drug over a period of time may require a controllable, constant flow of the drug from the device.
- a constant dose rate may be difficult to sustain.
- U.S. Pat. No. 3,840,009 to Michaels et al. discloses a vapor pressure drug delivery device which has two chambers separated by a flexible wall or bladder.
- the outer chamber contains a drug to be administered to a patient
- the inner chamber contains a pressure fluid which expands to conform to the shape of the outer chamber, thereby enabling expulsion of substantially all of the drug within the outer chamber.
- the pressure fluid is maintained at a positive pressure at the temperature at which the device is used, so that no external power source is required.
- U.S. Pat. No. 5,167,633 to Mann et al. discloses a medication infusion pump in which a constant pressure is exerted on a liquid medication to be administered.
- the pump includes a pressure reservoir in the form of a hollow enclosure with at least one flexible wall for containing a pressure fluid.
- the medication to be administered is outside of the pressure reservoir.
- the pressure fluid undergoes a phase change from a liquid to a vapor so as to expel the drug from the pump.
- the Mann et al. device is maintained at a negative pressure at the temperature of use to avoid leakage of medication from the pump into the patient.
- U.S. Pat. No. 5,514,103 to Srisathapat et al. discloses a medication infusion pump including a drug reservoir and a pressure fluid reservoir which are separated by a movable wall or flexible bag.
- the pressure fluid reservoir includes a spacer therein to prevent contraction of the pressure fluid reservoir below a minimum volume which is slightly greater than the liquid phase volume of the pressure fluid, so that a portion of the pressure fluid always remains in a vapor phase. As a result, even when the drug reservoir is completely filled, the pressure fluid is not entirely in the liquid phase. Thus, additional energy to reinstate a vapor phase is not required.
- U.S. Pat. No. 3,951,147 to Tucker et al. discloses a refillable implantable infusate pump in which a bellows containing a drug is contained within a housing which is filled with a pressure fluid or propellant.
- the Tucker et al. pump includes a filtering chamber to ensure removal of debris from the infusate drug prior to its delivery to the patient.
- U.S. Pat. No. 5,045,064 to Idriss discloses a constant pressure implantable pump which employs shape-memory metal bands around a reservoir containing a fluid to be infused.
- the bands compress the reservoir containing the fluid to be infused, thereby eliminating the need for a propellant.
- U.S. Pat. No. 5,395,324 to Hinrichs et al. discloses an infusion pump having a primary entry port leading to a drug reservoir, a separate bolus port leading to a bolus chamber, and means for ensuring that the bolus chamber is not inadvertently filled with the drug intended for the primary drug reservoir.
- U.S. Pat. No. 5,769,823 to Otto discloses an implantable infusion pump which comprises a plastic housing, a bellows chamber enclosing a propellant, and two separate resilient plastic bags enclosing an infusate.
- the bags are surrounded by glycerin or the like which binds with any propellant passing through the bellows wall into the housing, thereby preventing passage of the propellant through the housing into the patient.
- U.S. Pat. No. 5,575,770 to Melsky et al. discloses an implantable infusion pump having a valve-actuated bolus delivery chamber. Inadvertent administration of an overdose to the patient through the bolus delivery chamber is prevented by a design which requires the use of a side-access delivery needle, which is inserted through a pair of septa which are spaced apart to define a bolus chamber. The tip of the needle extends beyond the lower septum and depresses a lever to actuate the normally-closed valve. The side opening of the needle is disposed between the septa in the bolus chamber for delivery of the bolus dose to the bolus chamber. The design prevents erroneous dose delivery by requiring the simultaneous opening of the valve with delivery of the drug into the bolus using a side-access delivery needle.
- an implantable infusion device comprising a housing having an annular portion with an inner wall defining an interior region having a width dimension ID and extending along a central axis, a bottom portion extending from the annular portion and spanning a first end of the interior region, and a top portion extending from the annular portion and spanning a second end of the interior region and being opposite the bottom portion, the interior region being substantially closed.
- the device further includes a closed fluid-impermeable hollow bellows extending from one of the top and bottom portions of the housing and defining a variable volume region therein and having a plurality of serially coupled annular members extending between top and bottom portions of the bellows.
- the bellows has a maximum outer width dimension D′ where D′ is less than D.
- the portion of the housing from which the bellows extends includes a substantially planar annular peripheral portion disposed about a central portion.
- a pressure source is contained within the variable volume region of the bellows.
- the bellows is disposed within the interior region of the housing and rigidly coupled to the portion of the housing from which it extends.
- the annular members, of the bellows are spaced apart from the annular portion of the housing.
- the housing includes a recharging fluid flow path from points external to the housing to a region adjacent to the central portion of the portion of the housing from which the bellows extends.
- the housing further defines a fluid exit flow path extending from the region between the bellows and the annular portion of the housing to points external to the housing.
- the device further includes a pierceable, self-sealing septum disposed in the recharging fluid flow path and may further include a recharging fluid reservoir disposed along the recharging fluid flow path.
- the septum may be removable from the housing.
- the device further includes at least one of a flow restrictor and a filter disposed along the fluid exit flow path.
- the housing is made of a gas-impermeable material
- the bellows which encloses the pressure source is made of a substantially rigid, gas-impermeable material.
- the bellows is hermetically sealed.
- the pressure source comprises one or more of the group consisting of multiple-phase fluids, springs, shape memory metal alloys, Belville washers, and compressible materials.
- a multiple-phase fluid propellant is present in at least one of a liquid phase and a gas phase within the variable volume region of the bellows as a function of ambient temperature. Conversion of the propellant fluid from a liquid phase to a gas phase increases the volume displaced by the bellows in the interior region of the housing, thereby exerting a force on a fluid external to the bellows in the housing so as to provide a substantially constant flow rate of the fluid through the fluid exit flow path.
- the propellant is disposed in the variable volume region of the bellows at a pressure which is not less than atmospheric pressure at ambient temperature.
- the central portion of the bellows is offset from the plane of the annular peripheral portion of said bellows.
- a central region of the portion of the housing from which the bellows extends is correspondingly offset from the plane of the annular portion of the housing.
- the offset central region of the housing substantially nests within the offset central portion of the bellows.
- the housing and bellows are cylindrical.
- the device can further include a separate bolus port in fluid communication with the fluid exit flow path.
- the bolus port can include a pair of septa which are spaced apart to define a bolus reservoir therebetween.
- a side-access delivery needle having an opening near the center of its length is required to delivery a bolus dose of the infusate to the bolus reservoir.
- the bellows extends from the top portion of the housing. In another preferred embodiment, the bellows extends from the bottom portion of the housing.
- an implantable infusion device comprising a housing having an annular portion with an inner wall defining an interior region having a width dimension D and extending along a central axis, a bottom portion extending from the annular portion and spanning a first end of the interior region, and a top portion extending from the annular portion and spanning a second end of the interior region, the top portion being opposite the bottom portion, the interior region being substantially closed.
- the device further includes a closed fluid-impermeable hollow bellows disposed about a variable volume region and having a top member, a bottom member, and a plurality of serially coupled annular members extending therebetween. Junctions of the coupled annular members are coupled with flexures.
- the bellows has a maximum outer width dimension D′ where D′ is less than D.
- At least one of the top and bottom members includes a substantially planar annular peripheral portion disposed about a central portion.
- a pressure source is contained within the variable volume region of the bellows, and the bellows is disposed within the interior region of the housing with one of the top and bottom members facing and rigidly coupled to a corresponding portion of the housing.
- the annular members of the bellows are spaced apart from the annular portion of the housing.
- the housing includes a recharging fluid flow path from points external to the housing to a region adjacent to the central portion of one of the top and bottom members of the bellows.
- the region of coupling between the housing and the bellows defines a fluid dispersal flow path from the region adjacent to the central portion of the coupled member of the bellows to a region between the annular members of the bellows and the annular portion of the housing.
- the housing further defines a fluid exit flow path extending from the region between the bellows and the annular portion of the housing to points external to the housing.
- a central portion of at least one of the top and bottom members of the bellows is offset from the plane of the annular peripheral portion of the top and bottom members of the bellows.
- a central region of the portion of the housing which is coupled to the bellows is correspondingly offset from the plane of the annular portion of the housing, so that the offset central region of the portion of the housing which is coupled to the bellows nests within the central portion of the coupled portion of the bellows.
- the bellows is coupled to the top portion of the housing. In another preferred embodiment, the bellows is coupled to the bottom portion of the housing.
- a septum replacement kit for an enclosed device which is sealed with a septum, wherein the enclosed device defines a fluid reservoir, a fluid flow inlet and a fluid flow outlet.
- the kit comprises a compressible septum adapted to sealingly engage in the fluid flow inlet of the reservoir, and a septum installation tool adapted to compress the septum to a nominal insertion size, maintain the nominal insertion size of the septum prior to installation of the septum, and install the septum in the fluid flow inlet of the reservoir.
- the septum installation tool preferably comprises a tubular member adapted for insertion into the fluid flow inlet of the reservoir, an opening in the tubular member for insertion and retention of the septum therein, and a plunger member disposable in the tubular member for expulsion of the septum from the tubular member. Insertion of the septum into the tubular member compresses the septum. Expulsion of the septum from the tubular member into the fluid inlet reservoir permits the septum to expand to fill in and seal the fluid inlet reservoir.
- the septum is preferably made of a pierceable, self-sealing elastomeric or rubber-like material.
- FIG. 1 is a perspective view of an infusion device according to the invention
- FIG. 2 is a schematic diagram of the device which illustrates its structure and principles of operation
- FIG. 3 is a sagittal view of the device of FIG. 1;
- FIG. 4 is a sagittal view of an alternate design of the device, in which the sideport bolus port is located at an angle on a peripheral edge of the device;
- FIG. 5 is a sagittal view of a replaceable septum in a device according to the present invention.
- FIGS. 6A-6C illustrate a septum replacement kit and the steps for installing a replacement septum with a septum replacement tool
- FIGS. 7A-7B illustrate a bolus port safety feature which prevents inadvertent administration of an overdose of drug to the patient through the bolus injection port.
- the infusion device of the present invention combines several features known in the art in a novel and unobvious way.
- the device has a relatively low profile, as shown in FIGS. 1, 3 and 4 , and is remarkable in several aspects.
- the device can be housed in a lightweight, biologically inert material which need not be hermetically sealed. This is because, unlike most prior art infusion devices, the pressure source in the claimed device, which can be a propellant fluid, a mechanical spring or the like, or a combination of such elements, is contained in a separate enclosed container within the housing of the device, and the infusate, or drug to be administered, is outside the container containing the pressure source.
- the container for the pressure source ideally is in the form of a variable volume container, such as a metal bellows or a flexible bag or envelope.
- the variable volume container has a defined maximum and minimum volume.
- the infusate is administered to the patient from the device upon expansion of the variable volume container within the interior region of the housing until the variable volume container effectively fills the interior volume of the housing, at which point the infusate is substantially depleted.
- the device can also be transcutaneously recharged with infusate without requiring that the device be removed from the patient. Recharging the infusate effectively recharges the pressure source by compressing the variable volume container to its minimum volume and creating pressure which is used to expel the infusate from the device.
- the device also includes a separate bolus injection port for introduction of a bolus dose to the patient which bypasses the pressure source-driven delivery of the infusate from the principal reservoir of the device.
- Pierceable, self-sealing septa through which infusate can be injected into the device are located in the primary and bolus ports of the device for convenient introduction and containment of infusate and bolus injections.
- the housing can be made of a lightweight material, such as plastic, many features, such as fluid flow channels, compartments, needle stops and suture loops, can be integrated into the housing during its manufacture, which can be accomplished by molding or other low-cost, high-volume manufacturing processes.
- FIG. 1 shows a perspective view of the infusion device 10 according to the invention.
- FIG. 2 illustrates in schematic form the basic structure and principle of operation of the device.
- FIG. 3 is a detailed sectional view of the device of FIG. 1 along a sagittal (vertical longitudinal) axis.
- FIG. 4 is a sagittal view of an alternate design of the device, in which the side bolus port is located at an angle from a top edge of the device.
- FIG. 5 is a sagittal view of a replaceable septum for the device.
- FIGS. 6A-6C illustrate a septum replacement kit and a method of using it to remove a worn septum and replace it with a fresh septum.
- FIGS. 7A-7B illustrate a bolus safety feature which prevents the inadvertent administration of a principal dose of the drug to be infused through the bolus injection port.
- the device 10 is contained within a housing 12 made of a lightweight, durable, and biologically inert material, such as plastic.
- the housing is conveniently formed of an upper housing 12 a and a lower housing 12 b , which are joined with an o-ring 14 between them to create a fluid-impermeable seal.
- the halves of the housing can be joined by, for example, ultrasonic or thermal welding, solvent bonding, or other adhesive-based bonding.
- the housing of the device defines an interior region which forms a principal reservoir 16 for the infusate 18 , which is typically a drug to be administered over a period of time at a constant low dose to a patient into which the device has been surgically implanted.
- the infusate is introduced into the principal reservoir via a principal entry port 20 , which is sealed with a pierceable, self-sealing septum 22 .
- the infusate is delivered from the principal reservoir to a catheter 24 via exit flow path 25 , which may contain at least one of a filter 26 and a flow restrictor 28 .
- the device can include a separate restrictor chamber in the upper half 12 a .
- This separate restrictor chamber permits the use of interchangeable restrictors for establishing different infusate flow rates.
- a pressure source P contained within a variable volume enclosed chamber 30 , which may be attached to the housing, preferably to the upper housing 12 a , as detailed more fully below.
- the pressure source may be a multiple-phase fluid which expands from a liquid phase to a gas phase with increasing temperature, thereby increasing in volume and pushing against the walls of the variable volume container to enlarge it, thereby decreasing the volume of the principal reservoir 16 and expelling the infusate therein from the device.
- the pressure source can be a mechanical device, such as a spring or other compressible member, or a shape-memory metal alloy.
- a combination of a propellant fluid and a compressible mechanical member may also be used to obtain a desired infusate delivery rate from the device.
- the mechanical member may, but need not, exert a constant force throughout its stoke range.
- a propellant fluid is used as the pressure source within the variable volume chamber, it is desirable to have the minimum volume of the chamber be greater than the liquid volume of the propellant fluid, so that the propellant fluid must always exist in the chamber in both liquid and gas phases.
- a propellant fluid which is at a pressure of not less than one atmosphere at ambient temperature, so that at the temperature of use (typically nominal body temperature of the patient) the propellant is at a pressure which is even higher than one atmosphere of pressure. This allows the surgeon to prime and operate the device at ambient temperature in order to verify its performance prior to implantation of the device in the patient, thereby eliminating the need to warm the device and the infusate to body temperature.
- such a positive pressure device eliminates the risk that outside air or gases will be drawn into the device during storage of the device.
- the inert plastic housing containing the infusate 12 may, but need not, be hermetically sealed.
- the housing if made of a moldable or easily formed material, may include, for example, integrally formed needle stops 32 , 34 for the primary and bolus injection sites, as well as one or more integrally formed suture loops 36 for passage of anchoring sutures therethrough.
- the variable volume chamber 30 is desirably a substantially rigid, gas-impermeable bellows structure, as illustrated in FIGS. 3 and 4, or other similar rigid-walled or spring-driven structure which occupies a volume which approximates the volume of the principal reservoir 16 .
- Preferred materials for the bellows chamber include metals and plastics.
- An important feature of the variable volume chamber is its width dimension or diameter D′ relative to the diameter D of the housing. It is necessary to have D′ be less than D, so that the bellows walls are spaced from the housing walls, but only by so much as will allow the bellows walls to move freely within the housing.
- the device and bellows are illustrated as cylindrical in a preferred embodiment, they may have any convenient shape.
- variable volume chamber must not be located so that it obstructs the principal entry port for infusate when the principal reservoir is empty and the variable volume chamber is at its maximum volume.
- the variable volume chamber 30 may be attached to the housing so as to define a fluid flow path between the variable volume chamber and the housing.
- the chamber 30 and housing 12 may be designed to share a common wall which may be channeled to provide fluid flow paths along the interface between the housing and the chamber 30 .
- the bellows may be freely located in the interior region of the housing. In this embodiment, the free bellows is desirably held away from the infusate entry port by standoffs extending from the bellows or from the infusate entry port.
- the housing To ensure as low a profile as possible for the device, it is desirable to construct the housing so that the central portion of one or both of its top and bottom portions, along with corresponding central portions of the top and bottom members of the bellows, is offset or depressed from the nominal plane of the central portions as shown in FIGS. 3 and 4 to form a nested structure.
- the infusate entry port nests within a recessed central portion of the bellows.
- Reductions in the volume of the infusate chamber 30 reduce the amount of infusate that can be administered and increase the frequency with which the chamber 30 must be recharged if drug delivery is to take place over an extended period.
- the pressure source can be selected so as to maximize delivery from a given volume.
- the device includes a separate bolus injection port 38 , which includes a bolus entry port 40 sealed with a pierceable, self-sealing septum 42 , and leading to a bolus reservoir 44 , which is in fluid communication with the fluid exit flow path 25 and delivery catheter 24 , yet downstream of the filter 26 and flow restrictor 28 .
- Infusate introduced into the bolus port goes directly into the delivery catheter and bypasses the controlled release provided by the action of the pressure source and variable volume chamber on the infusate in the principal reservoir.
- Both the principal infusate entry port and the bolus injection port may include sensing devices known in the art which assist the patient and medical staff in locating the devices transdermally so that additional infusate can be introduced to the device without the need for external palpation or surgical removal of the device.
- the life of an implantable infusion device such as those described herein is determined in large part by the life of the septum through which the infusate is introduced.
- a self-sealing material such as an elastomer, silicone rubber or similar material, for the septum allows the septum to reseal after it has been pierced with a needle.
- self-sealing materials lose some elasticity after a certain number of uses and must be replaced to ensure that no infusate leaks out of the device.
- Septum life, and thus infusion device life, can be optimized by careful selection of the septum material and the dimensions of the septum and the septum chamber in the device. This is shown in FIG. 5.
- the ratio of the opening dimension of the septum chamber (B) to the width of the septum chamber (A) must be such that the entire septum volume can fit within the chamber opening B when the septum is compressed, and such that the chamber width A adequately compresses the septum to provide satisfactory puncture life.
- the selection of a material for the septum is also an important consideration, as its hardness, as measured by a durometer, must allow for adequate compression of the septum during insertion without comprising puncture life.
- the height of the septum chamber (C) must be sufficient to permit the compressed septum to fill the chamber and still be sufficiently axially compressed to achieve the desired puncture life.
- FIGS. 6A-6C A septum replacement kit allows the surgeon to replace a worn septum without surgically removing the device from the patient.
- a kit is illustrated in FIGS. 6A-6C.
- FIG. 6A shows a septum 22 , which is typically in the form of a cylindrical or square plug of height H and width W.
- the septum is preferably made of a compressible, resilient, penetrable, self-sealing material, such as a rubber or elastomer.
- FIG. 6B shows the septum lodged in a tubular member 46 , which is sized to fit into the entry port 20 , having width B, of the infusion device 12 .
- the septum is easily compressed sufficiently to be lodged into the tubular member 46 , and a plunger 48 is used to dislodge the septum from the tubular member into the septum chamber 50 , which has width A and height C, after it is inserted into the entry port 20 , as shown in FIG. 6C.
- the septum is radially compressed in the chamber to form a penetrable seal. The plunger and tubular member can then be withdrawn.
- Removal of a worn septum can be accomplished by inserting a sharp instrument into the septum to cut it into sections that can then be removed from the septum chamber with tweezers or other suitable instrument.
- FIGS. illustrate use of the septum replacement kit for replacing the primary septum 22
- the kit can also be used to replace the bolus septum 42 in the bolus injection port 40 .
- the device may include safety filling devices known in the art to ensure that the patient and medical staff can distinguish between the primary entry port and the bolus injection port so as to avoid inadvertent administration of relatively large doses intended to be administered over time to the patient.
- safety filling devices known in the art to ensure that the patient and medical staff can distinguish between the primary entry port and the bolus injection port so as to avoid inadvertent administration of relatively large doses intended to be administered over time to the patient.
- it may be difficult to determine whether a refill needle is positioned to enter the principal infusate port or the bolus port. Entry of the refill needle into the wrong port for the dose being administered can result in a patient receiving an excessive dose of the drug and therefore must be prevented.
- FIG. 7A illustrates the two infusate ports in a typical implantable infusion pump according to the invention.
- the device includes a principal, or center, access port ( 1 ) for administration of infusate into the device, and a bolus access port ( 2 ) for administration of a bolus injection directly to the patient.
- the center access port ( 1 ) includes a single septum, below which is disposed an infusate reservoir R. To fill the center access port ( 1 ), a refill needle having a hole in the tip, as shown in ( 1 ), is required.
- the side bolus access port ( 2 ) includes two septa which are spaced apart to define an infusate reservoir R between them.
- the top septum in the bolus access port ( 2 ) secures the delivery needle in place and provides a seal to prevent leakage of the bolus dose once the needle is removed from the bolus port.
- the bottom septum blocks the opening in the tip of a standard refill needle, shown in ( 1 ), should such a needle be inserted into the bolus port. Only a special needle with a side-access opening near the center of its length, as shown in ( 2 ), instead of at or near the tip, as shown in ( 1 ), can be used to fill the bolus port.
- FIG. 7B shows the result of using a standard delivery needle in the bolus port.
- the standard delivery needle includes an opening at its tip and no opening in the side. The opening in the tip will be blocked by the lower septum when the needle is inserted into the bolus port, and no infusate will be delivered.
- This design of the center and bolus ports in the device of the invention ensures that no bolus dose can be administered inadvertently to a patient, because only a bolus (side-access opening) needle can be used in the bolus port. If a standard delivery needle is accidentally inserted into the bolus port, no infusate can be delivered, and the surgeon can see immediately that the wrong needle is being toed, without administering any harmful dose to the patient.
Abstract
An implantable infusion device includes a lightweight, inert housing which contains an infusate for administration to a patient, and an enclosed, gas-impermeable variable volume chamber which contains a pressure source, such as propellant, mechanical spring, or the like. The variable volume chamber may be in the form of a rigid-walled expandable bellows structure or a nonstretchable flexible bag and is attached to the housing so as not to obstruct the entry port for introduction of infusate. The infusate is delivered from the device via a catheter in response to expansion of the variable volume chamber against the volume of infusate in the housing. A separate bolus injection port is provided which allows infusate to be safely introduced directly into the catheter and overrides the controlled pressure-driven delivery. The lightweight housing may include integrally formed needle stops and suture fastening loops.
Description
- This application is a continuation of U.S. application Ser. No. 09/481,298, filed Jan. 11, 2000, now pending.
- The invention relates to implantable infusion devices for controllable in vivo delivery of drugs to a patient.
- Implantable infusion devices provide a patient with an in vivo source of a drug to be administered, in a device which permits controlled delivery of the drug over a predetermined time period. Certain drugs, such as, for example, chemotherapy drugs and opioids, may be most effective if administered at a constant dose rate, instead of at discrete intervals.
- A typical infusion device or pump includes a hermetically sealed outer housing which holds a vapor pressure fluid or other means for exerting a compressive force on a compressible or flexible inner drug reservoir which communicates with a drug delivery port. Alternatively, the drug may be disposed in the outer housing, with a propellant disposed in the inner housing. When the outer housing is filled with the drug, the propellant in the inner housing is compressed and changes state from a vapor to a liquid, thereby recharging the driving mechanism of the device. In still other embodiments, the outer housing may be divided into two chambers separated by a liquid-impermeable diaphragm. One chamber contains the drug and includes a drug delivery port, and the other chamber contains a propellant or spring member for exerting a force against the diaphragm so as to expel the drug through the delivery port.
- The infusion device must meet numerous requirements for safety and efficacy. For example, the housing material must not react with body fluids or with the drugs and propellants inside the housing. Further, the membrane or flexible barrier between the chambers must not leak and must be impermeable to gas-phase fluids so as to prevent contamination of the drug with the propellant. Since the device is designed for implantation into a patient, great care must be taken to prevent any leakage of either the drug or the propellant into the patient's body. In addition, the device is desirably as small and lightweight as possible so as to cause minimum invasive trauma, discomfort and disfigurement to the patient, yet sufficiently large to provide a useful therapeutic dosage of the drug being administered and minimize the frequency with which the device must be recharged. It is desirable to make the pump refillable so that it need not be surgically removed and replaced when the drug is depleted. However, refillability of the pump requires a port which is either outside of the skin or transcutaneously accessible without introducing infection or risking the release of an excessive and potentially harmful amount of the drug into the patient. Also, in those devices in which a propellant is contained within a flexible bag which expands and contracts in response to changes in the propellant pressure, it is necessary to ensure that introduction of the drug to the drug reservoir surrounding the propellant bag is not impeded by the presence and location of the bag in the reservoir and/or does not puncture or pinch the bag. Thus, it may be necessary to affix the propellant chamber or bag to the housing so as to avoid such problems. There is the additional problem of ensuring that the drug reservoir can be fully depleted and refilled, for optimum efficiency of the device.
- Administration of a desired dosage of a drug over a period of time may require a controllable, constant flow of the drug from the device. However, as the drug is depleted from the reservoir, or if the force exerted on the drug reservoir cannot be controlled, a constant dose rate may be difficult to sustain.
- U.S. Pat. No. 3,840,009 to Michaels et al. discloses a vapor pressure drug delivery device which has two chambers separated by a flexible wall or bladder. The outer chamber contains a drug to be administered to a patient, and the inner chamber contains a pressure fluid which expands to conform to the shape of the outer chamber, thereby enabling expulsion of substantially all of the drug within the outer chamber. The pressure fluid is maintained at a positive pressure at the temperature at which the device is used, so that no external power source is required.
- U.S. Pat. No. 5,167,633 to Mann et al. discloses a medication infusion pump in which a constant pressure is exerted on a liquid medication to be administered. The pump includes a pressure reservoir in the form of a hollow enclosure with at least one flexible wall for containing a pressure fluid. The medication to be administered is outside of the pressure reservoir. The pressure fluid undergoes a phase change from a liquid to a vapor so as to expel the drug from the pump. The Mann et al. device is maintained at a negative pressure at the temperature of use to avoid leakage of medication from the pump into the patient.
- U.S. Pat. No. 5,514,103 to Srisathapat et al. discloses a medication infusion pump including a drug reservoir and a pressure fluid reservoir which are separated by a movable wall or flexible bag. The pressure fluid reservoir includes a spacer therein to prevent contraction of the pressure fluid reservoir below a minimum volume which is slightly greater than the liquid phase volume of the pressure fluid, so that a portion of the pressure fluid always remains in a vapor phase. As a result, even when the drug reservoir is completely filled, the pressure fluid is not entirely in the liquid phase. Thus, additional energy to reinstate a vapor phase is not required.
- U.S. Pat. No. 3,951,147 to Tucker et al. discloses a refillable implantable infusate pump in which a bellows containing a drug is contained within a housing which is filled with a pressure fluid or propellant. The Tucker et al. pump includes a filtering chamber to ensure removal of debris from the infusate drug prior to its delivery to the patient.
- U.S. Pat. No. 5,045,064 to Idriss discloses a constant pressure implantable pump which employs shape-memory metal bands around a reservoir containing a fluid to be infused. The bands compress the reservoir containing the fluid to be infused, thereby eliminating the need for a propellant.
- U.S. Pat. No. 5,395,324 to Hinrichs et al. discloses an infusion pump having a primary entry port leading to a drug reservoir, a separate bolus port leading to a bolus chamber, and means for ensuring that the bolus chamber is not inadvertently filled with the drug intended for the primary drug reservoir.
- U.S. Pat. No. 5,769,823 to Otto discloses an implantable infusion pump which comprises a plastic housing, a bellows chamber enclosing a propellant, and two separate resilient plastic bags enclosing an infusate. The bags are surrounded by glycerin or the like which binds with any propellant passing through the bellows wall into the housing, thereby preventing passage of the propellant through the housing into the patient.
- U.S. Pat. No. 5,575,770 to Melsky et al. discloses an implantable infusion pump having a valve-actuated bolus delivery chamber. Inadvertent administration of an overdose to the patient through the bolus delivery chamber is prevented by a design which requires the use of a side-access delivery needle, which is inserted through a pair of septa which are spaced apart to define a bolus chamber. The tip of the needle extends beyond the lower septum and depresses a lever to actuate the normally-closed valve. The side opening of the needle is disposed between the septa in the bolus chamber for delivery of the bolus dose to the bolus chamber. The design prevents erroneous dose delivery by requiring the simultaneous opening of the valve with delivery of the drug into the bolus using a side-access delivery needle.
- It would be advantageous to provide an implantable infusion pump which is of simple construction and operation, made of lightweight materials, inexpensive to manufacture, efficient in the delivery of medicine, and easy to refill.
- According to one aspect of the invention, there is provided an implantable infusion device, comprising a housing having an annular portion with an inner wall defining an interior region having a width dimension ID and extending along a central axis, a bottom portion extending from the annular portion and spanning a first end of the interior region, and a top portion extending from the annular portion and spanning a second end of the interior region and being opposite the bottom portion, the interior region being substantially closed. The device further includes a closed fluid-impermeable hollow bellows extending from one of the top and bottom portions of the housing and defining a variable volume region therein and having a plurality of serially coupled annular members extending between top and bottom portions of the bellows. Junctions of the coupled annular members are coupled with flexures. The bellows has a maximum outer width dimension D′ where D′ is less than D. The portion of the housing from which the bellows extends includes a substantially planar annular peripheral portion disposed about a central portion. A pressure source is contained within the variable volume region of the bellows. The bellows is disposed within the interior region of the housing and rigidly coupled to the portion of the housing from which it extends. The annular members, of the bellows are spaced apart from the annular portion of the housing. The housing includes a recharging fluid flow path from points external to the housing to a region adjacent to the central portion of the portion of the housing from which the bellows extends. The housing further defines a fluid exit flow path extending from the region between the bellows and the annular portion of the housing to points external to the housing.
- The device further includes a pierceable, self-sealing septum disposed in the recharging fluid flow path and may further include a recharging fluid reservoir disposed along the recharging fluid flow path. The septum may be removable from the housing.
- The device further includes at least one of a flow restrictor and a filter disposed along the fluid exit flow path.
- In one embodiment, the housing is made of a gas-impermeable material, and the bellows which encloses the pressure source is made of a substantially rigid, gas-impermeable material. In a preferred embodiment, the bellows is hermetically sealed.
- The pressure source comprises one or more of the group consisting of multiple-phase fluids, springs, shape memory metal alloys, Belville washers, and compressible materials. In one embodiment, a multiple-phase fluid propellant is present in at least one of a liquid phase and a gas phase within the variable volume region of the bellows as a function of ambient temperature. Conversion of the propellant fluid from a liquid phase to a gas phase increases the volume displaced by the bellows in the interior region of the housing, thereby exerting a force on a fluid external to the bellows in the housing so as to provide a substantially constant flow rate of the fluid through the fluid exit flow path.
- In a preferred embodiment, the propellant is disposed in the variable volume region of the bellows at a pressure which is not less than atmospheric pressure at ambient temperature.
- In one embodiment, the central portion of the bellows is offset from the plane of the annular peripheral portion of said bellows. A central region of the portion of the housing from which the bellows extends is correspondingly offset from the plane of the annular portion of the housing. The offset central region of the housing substantially nests within the offset central portion of the bellows.
- In one embodiment, the housing and bellows are cylindrical.
- The device can further include a separate bolus port in fluid communication with the fluid exit flow path. The bolus port can include a pair of septa which are spaced apart to define a bolus reservoir therebetween. A side-access delivery needle having an opening near the center of its length is required to delivery a bolus dose of the infusate to the bolus reservoir.
- In one preferred embodiment, the bellows extends from the top portion of the housing. In another preferred embodiment, the bellows extends from the bottom portion of the housing.
- According to another aspect of the invention, there is provided an implantable infusion device, comprising a housing having an annular portion with an inner wall defining an interior region having a width dimension D and extending along a central axis, a bottom portion extending from the annular portion and spanning a first end of the interior region, and a top portion extending from the annular portion and spanning a second end of the interior region, the top portion being opposite the bottom portion, the interior region being substantially closed. The device further includes a closed fluid-impermeable hollow bellows disposed about a variable volume region and having a top member, a bottom member, and a plurality of serially coupled annular members extending therebetween. Junctions of the coupled annular members are coupled with flexures. The bellows has a maximum outer width dimension D′ where D′ is less than D. At least one of the top and bottom members includes a substantially planar annular peripheral portion disposed about a central portion. A pressure source is contained within the variable volume region of the bellows, and the bellows is disposed within the interior region of the housing with one of the top and bottom members facing and rigidly coupled to a corresponding portion of the housing. The annular members of the bellows are spaced apart from the annular portion of the housing. The housing includes a recharging fluid flow path from points external to the housing to a region adjacent to the central portion of one of the top and bottom members of the bellows. The region of coupling between the housing and the bellows defines a fluid dispersal flow path from the region adjacent to the central portion of the coupled member of the bellows to a region between the annular members of the bellows and the annular portion of the housing. The housing further defines a fluid exit flow path extending from the region between the bellows and the annular portion of the housing to points external to the housing.
- In one embodiment, a central portion of at least one of the top and bottom members of the bellows is offset from the plane of the annular peripheral portion of the top and bottom members of the bellows. A central region of the portion of the housing which is coupled to the bellows is correspondingly offset from the plane of the annular portion of the housing, so that the offset central region of the portion of the housing which is coupled to the bellows nests within the central portion of the coupled portion of the bellows.
- In one preferred embodiment, the bellows is coupled to the top portion of the housing. In another preferred embodiment, the bellows is coupled to the bottom portion of the housing.
- According to still another aspect of the invention, there is provided a septum replacement kit for an enclosed device which is sealed with a septum, wherein the enclosed device defines a fluid reservoir, a fluid flow inlet and a fluid flow outlet. The kit comprises a compressible septum adapted to sealingly engage in the fluid flow inlet of the reservoir, and a septum installation tool adapted to compress the septum to a nominal insertion size, maintain the nominal insertion size of the septum prior to installation of the septum, and install the septum in the fluid flow inlet of the reservoir.
- The septum installation tool preferably comprises a tubular member adapted for insertion into the fluid flow inlet of the reservoir, an opening in the tubular member for insertion and retention of the septum therein, and a plunger member disposable in the tubular member for expulsion of the septum from the tubular member. Insertion of the septum into the tubular member compresses the septum. Expulsion of the septum from the tubular member into the fluid inlet reservoir permits the septum to expand to fill in and seal the fluid inlet reservoir.
- The septum is preferably made of a pierceable, self-sealing elastomeric or rubber-like material.
- These and other objects and advantages of the invention will in part be obvious and will in part appear hereinafter. The invention accordingly comprises the apparatus possessing the construction, combination of elements and arrangement of parts which are exemplified in the following detailed disclosure, the scope of which will be indicated in the claims.
- For a fuller understanding of the nature and objects of the present invention, reference should be made to the following detailed description taken in connection with the accompanying drawings, in which:
- FIG. 1 is a perspective view of an infusion device according to the invention;
- FIG. 2 is a schematic diagram of the device which illustrates its structure and principles of operation;
- FIG. 3 is a sagittal view of the device of FIG. 1;
- FIG. 4 is a sagittal view of an alternate design of the device, in which the sideport bolus port is located at an angle on a peripheral edge of the device;
- FIG. 5 is a sagittal view of a replaceable septum in a device according to the present invention;
- FIGS. 6A-6C illustrate a septum replacement kit and the steps for installing a replacement septum with a septum replacement tool; and
- FIGS. 7A-7B illustrate a bolus port safety feature which prevents inadvertent administration of an overdose of drug to the patient through the bolus injection port.
- Like features in the drawings are indicated with like numerals.
- The infusion device of the present invention combines several features known in the art in a novel and unobvious way. The device has a relatively low profile, as shown in FIGS. 1, 3 and4, and is remarkable in several aspects. First, the device can be housed in a lightweight, biologically inert material which need not be hermetically sealed. This is because, unlike most prior art infusion devices, the pressure source in the claimed device, which can be a propellant fluid, a mechanical spring or the like, or a combination of such elements, is contained in a separate enclosed container within the housing of the device, and the infusate, or drug to be administered, is outside the container containing the pressure source.
- The container for the pressure source ideally is in the form of a variable volume container, such as a metal bellows or a flexible bag or envelope. However, unlike an expandable balloon bag, the variable volume container has a defined maximum and minimum volume. The infusate is administered to the patient from the device upon expansion of the variable volume container within the interior region of the housing until the variable volume container effectively fills the interior volume of the housing, at which point the infusate is substantially depleted.
- The device can also be transcutaneously recharged with infusate without requiring that the device be removed from the patient. Recharging the infusate effectively recharges the pressure source by compressing the variable volume container to its minimum volume and creating pressure which is used to expel the infusate from the device.
- The device also includes a separate bolus injection port for introduction of a bolus dose to the patient which bypasses the pressure source-driven delivery of the infusate from the principal reservoir of the device. Pierceable, self-sealing septa through which infusate can be injected into the device are located in the primary and bolus ports of the device for convenient introduction and containment of infusate and bolus injections.
- In addition, because the housing can be made of a lightweight material, such as plastic, many features, such as fluid flow channels, compartments, needle stops and suture loops, can be integrated into the housing during its manufacture, which can be accomplished by molding or other low-cost, high-volume manufacturing processes.
- FIG. 1 shows a perspective view of the
infusion device 10 according to the invention. FIG. 2 illustrates in schematic form the basic structure and principle of operation of the device. FIG. 3 is a detailed sectional view of the device of FIG. 1 along a sagittal (vertical longitudinal) axis. FIG. 4 is a sagittal view of an alternate design of the device, in which the side bolus port is located at an angle from a top edge of the device. FIG. 5 is a sagittal view of a replaceable septum for the device. FIGS. 6A-6C illustrate a septum replacement kit and a method of using it to remove a worn septum and replace it with a fresh septum. FIGS. 7A-7B illustrate a bolus safety feature which prevents the inadvertent administration of a principal dose of the drug to be infused through the bolus injection port. - The
device 10 is contained within ahousing 12 made of a lightweight, durable, and biologically inert material, such as plastic. The housing is conveniently formed of anupper housing 12 a and alower housing 12 b, which are joined with an o-ring 14 between them to create a fluid-impermeable seal. The halves of the housing can be joined by, for example, ultrasonic or thermal welding, solvent bonding, or other adhesive-based bonding. - The housing of the device defines an interior region which forms a
principal reservoir 16 for theinfusate 18, which is typically a drug to be administered over a period of time at a constant low dose to a patient into which the device has been surgically implanted. The infusate is introduced into the principal reservoir via aprincipal entry port 20, which is sealed with a pierceable, self-sealingseptum 22. The infusate is delivered from the principal reservoir to acatheter 24 viaexit flow path 25, which may contain at least one of afilter 26 and aflow restrictor 28. - In one preferred embodiment of the invention, the device can include a separate restrictor chamber in the
upper half 12 a. This separate restrictor chamber permits the use of interchangeable restrictors for establishing different infusate flow rates. - Delivery of the infusate from the principal reservoir is driven by a pressure source P contained within a variable volume enclosed
chamber 30, which may be attached to the housing, preferably to theupper housing 12 a, as detailed more fully below. The pressure source may be a multiple-phase fluid which expands from a liquid phase to a gas phase with increasing temperature, thereby increasing in volume and pushing against the walls of the variable volume container to enlarge it, thereby decreasing the volume of theprincipal reservoir 16 and expelling the infusate therein from the device. Alternatively, the pressure source can be a mechanical device, such as a spring or other compressible member, or a shape-memory metal alloy. A combination of a propellant fluid and a compressible mechanical member may also be used to obtain a desired infusate delivery rate from the device. The mechanical member may, but need not, exert a constant force throughout its stoke range. - If a propellant fluid is used as the pressure source within the variable volume chamber, it is desirable to have the minimum volume of the chamber be greater than the liquid volume of the propellant fluid, so that the propellant fluid must always exist in the chamber in both liquid and gas phases. In addition, it is desirable to select a propellant fluid which is at a pressure of not less than one atmosphere at ambient temperature, so that at the temperature of use (typically nominal body temperature of the patient) the propellant is at a pressure which is even higher than one atmosphere of pressure. This allows the surgeon to prime and operate the device at ambient temperature in order to verify its performance prior to implantation of the device in the patient, thereby eliminating the need to warm the device and the infusate to body temperature. In addition, such a positive pressure device eliminates the risk that outside air or gases will be drawn into the device during storage of the device.
- The inert plastic housing containing the
infusate 12 may, but need not, be hermetically sealed. The housing, if made of a moldable or easily formed material, may include, for example, integrally formed needle stops 32, 34 for the primary and bolus injection sites, as well as one or more integrally formedsuture loops 36 for passage of anchoring sutures therethrough. - The
variable volume chamber 30 is desirably a substantially rigid, gas-impermeable bellows structure, as illustrated in FIGS. 3 and 4, or other similar rigid-walled or spring-driven structure which occupies a volume which approximates the volume of theprincipal reservoir 16. Preferred materials for the bellows chamber include metals and plastics. An important feature of the variable volume chamber is its width dimension or diameter D′ relative to the diameter D of the housing. It is necessary to have D′ be less than D, so that the bellows walls are spaced from the housing walls, but only by so much as will allow the bellows walls to move freely within the housing. It is desirable to have the bellows walls as close as possible to the housing walls so that maximum displacement of infusate can be achieved by movement of the bellows in the reservoir. However, drag of the bellows walls on the housing walls must be avoided. Thus, it is desirable to have the variable volume chamber centered in the principal reservoir for maximum volume and avoidance of drag and so that the distance D-D′ is sufficient to avoid such drag. - Although the device and bellows are illustrated as cylindrical in a preferred embodiment, they may have any convenient shape.
- Another important consideration is that the variable volume chamber must not be located so that it obstructs the principal entry port for infusate when the principal reservoir is empty and the variable volume chamber is at its maximum volume. In a preferred embodiment, the
variable volume chamber 30 may be attached to the housing so as to define a fluid flow path between the variable volume chamber and the housing. Alternatively, thechamber 30 andhousing 12 may be designed to share a common wall which may be channeled to provide fluid flow paths along the interface between the housing and thechamber 30. In still another alternate embodiment, the bellows may be freely located in the interior region of the housing. In this embodiment, the free bellows is desirably held away from the infusate entry port by standoffs extending from the bellows or from the infusate entry port. - To ensure as low a profile as possible for the device, it is desirable to construct the housing so that the central portion of one or both of its top and bottom portions, along with corresponding central portions of the top and bottom members of the bellows, is offset or depressed from the nominal plane of the central portions as shown in FIGS. 3 and 4 to form a nested structure. The infusate entry port nests within a recessed central portion of the bellows. Although only the top portions of the housing and bellows are shown as nested in FIGS. 3 and 4, the bottom portions of the housing and bellows could also be nested to further reduce the height of the device. Reductions in the volume of the
infusate chamber 30 reduce the amount of infusate that can be administered and increase the frequency with which thechamber 30 must be recharged if drug delivery is to take place over an extended period. However, the pressure source can be selected so as to maximize delivery from a given volume. - The device includes a separate
bolus injection port 38, which includes abolus entry port 40 sealed with a pierceable, self-sealingseptum 42, and leading to abolus reservoir 44, which is in fluid communication with the fluidexit flow path 25 anddelivery catheter 24, yet downstream of thefilter 26 and flowrestrictor 28. Infusate introduced into the bolus port goes directly into the delivery catheter and bypasses the controlled release provided by the action of the pressure source and variable volume chamber on the infusate in the principal reservoir. - Both the principal infusate entry port and the bolus injection port may include sensing devices known in the art which assist the patient and medical staff in locating the devices transdermally so that additional infusate can be introduced to the device without the need for external palpation or surgical removal of the device.
- The life of an implantable infusion device such as those described herein is determined in large part by the life of the septum through which the infusate is introduced. Use of a self-sealing material, such as an elastomer, silicone rubber or similar material, for the septum allows the septum to reseal after it has been pierced with a needle. However, even self-sealing materials lose some elasticity after a certain number of uses and must be replaced to ensure that no infusate leaks out of the device.
- Septum life, and thus infusion device life, can be optimized by careful selection of the septum material and the dimensions of the septum and the septum chamber in the device. This is shown in FIG. 5. The ratio of the opening dimension of the septum chamber (B) to the width of the septum chamber (A) must be such that the entire septum volume can fit within the chamber opening B when the septum is compressed, and such that the chamber width A adequately compresses the septum to provide satisfactory puncture life. The selection of a material for the septum is also an important consideration, as its hardness, as measured by a durometer, must allow for adequate compression of the septum during insertion without comprising puncture life. The height of the septum chamber (C) must be sufficient to permit the compressed septum to fill the chamber and still be sufficiently axially compressed to achieve the desired puncture life.
- A septum replacement kit allows the surgeon to replace a worn septum without surgically removing the device from the patient. Such a kit is illustrated in FIGS. 6A-6C. FIG. 6A shows a
septum 22, which is typically in the form of a cylindrical or square plug of height H and width W. The septum is preferably made of a compressible, resilient, penetrable, self-sealing material, such as a rubber or elastomer. FIG. 6B shows the septum lodged in atubular member 46, which is sized to fit into theentry port 20, having width B, of theinfusion device 12. The septum is easily compressed sufficiently to be lodged into thetubular member 46, and aplunger 48 is used to dislodge the septum from the tubular member into theseptum chamber 50, which has width A and height C, after it is inserted into theentry port 20, as shown in FIG. 6C. The septum is radially compressed in the chamber to form a penetrable seal. The plunger and tubular member can then be withdrawn. - Removal of a worn septum can be accomplished by inserting a sharp instrument into the septum to cut it into sections that can then be removed from the septum chamber with tweezers or other suitable instrument.
- Although the FIGS. illustrate use of the septum replacement kit for replacing the
primary septum 22, the kit can also be used to replace thebolus septum 42 in thebolus injection port 40. - In addition, the device may include safety filling devices known in the art to ensure that the patient and medical staff can distinguish between the primary entry port and the bolus injection port so as to avoid inadvertent administration of relatively large doses intended to be administered over time to the patient. When an implanted infusion pump is to be refilled, it may be difficult to determine whether a refill needle is positioned to enter the principal infusate port or the bolus port. Entry of the refill needle into the wrong port for the dose being administered can result in a patient receiving an excessive dose of the drug and therefore must be prevented.
- A bolus safety feature in accordance with the present invention is shown and described in connection with FIGS. 7A-7B. FIG. 7A illustrates the two infusate ports in a typical implantable infusion pump according to the invention. The device includes a principal, or center, access port (1) for administration of infusate into the device, and a bolus access port (2) for administration of a bolus injection directly to the patient. The center access port (1) includes a single septum, below which is disposed an infusate reservoir R. To fill the center access port (1), a refill needle having a hole in the tip, as shown in (1), is required.
- In contrast, the side bolus access port (2) includes two septa which are spaced apart to define an infusate reservoir R between them. The top septum in the bolus access port (2) secures the delivery needle in place and provides a seal to prevent leakage of the bolus dose once the needle is removed from the bolus port. The bottom septum blocks the opening in the tip of a standard refill needle, shown in (1), should such a needle be inserted into the bolus port. Only a special needle with a side-access opening near the center of its length, as shown in (2), instead of at or near the tip, as shown in (1), can be used to fill the bolus port.
- FIG. 7B shows the result of using a standard delivery needle in the bolus port. The standard delivery needle includes an opening at its tip and no opening in the side. The opening in the tip will be blocked by the lower septum when the needle is inserted into the bolus port, and no infusate will be delivered.
- This design of the center and bolus ports in the device of the invention ensures that no bolus dose can be administered inadvertently to a patient, because only a bolus (side-access opening) needle can be used in the bolus port. If a standard delivery needle is accidentally inserted into the bolus port, no infusate can be delivered, and the surgeon can see immediately that the wrong needle is being toed, without administering any harmful dose to the patient.
- Because certain changes may be made in the above apparatus without departing from the scope of the invention herein disclosed, it is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpreted in an illustrative and not a limiting sense.
Claims (42)
1. An implantable infusion device, comprising:
A. a housing having (a) an annular portion with an inner wall defining an interior region having a width dimension D and extending along a central axis, (b) a bottom portion extending from said annular portion and spanning a first end of said interior region, and (c) a top portion extending from said annular portion and spanning a second end of said interior region, said top portion being opposite said bottom portion, wherein said interior region is substantially closed; and
B. a closed fluid-impermeable hollow bellows extending from one of the top and bottom portions of the housing and defining a variable volume region therein and having a plurality of serially coupled annular members extending between top and bottom portions of the bellows, wherein junctions of said coupled annular members are coupled with flexures, said bellows having a maximum outer width dimension D′ where D′ is less than D, wherein the portion of the housing from which the bellows extends includes a substantially planar annular peripheral portion disposed about a central portion, wherein a pressure source is contained within said variable volume region of said bellows, and wherein said bellows is disposed within said interior region of said housing and rigidly coupled to said portion of the housing from which the bellows extends, whereby said annular members of said bellows are spaced apart from said annular portion of said housing,
wherein said housing includes a recharging fluid flow path from points external to said housing to a region adjacent to said central portion of said portion of said housing from which the bellows extends, and
wherein said housing further defines a fluid exit flow path extending from the region between said bellows and said annular portion of said housing to points external to said housing.
2. An implantable infusion device according to claim 1 , further comprising a pierceable, self-sealing septum disposed in said recharging fluid flow path.
3. An implantable infusion device according to claim 2 , wherein the septum is removable from the housing.
4. An implantable infusion device according to claim 1 , further comprising a recharging fluid reservoir disposed along said recharging fluid flow path.
5. An implantable infusion device according to claim 1 , further comprising at least one of a flow restrictor and a filter disposed along said fluid exit flow path.
6. An implantable infusion device according to claim 1 , wherein said housing is made of a gas-impermeable material.
7. An implantable infusion device according to claim 1 , wherein the pressure source comprises one or more of the group consisting of multiple-phase fluids, springs, shape memory metal alloys, Belville washers, and compressible materials.
8. An implantable infusion device according to claim 1 , wherein a multiple-phase fluid propellant is present in at least one of a liquid phase and a gas phase within said variable volume region of said bellows as a function of ambient temperature, wherein conversion of the propellant from a liquid phase to a gas phase increases the volume displaced by the bellows in the interior region of the housing, thereby exerting a force on a fluid external to said bellows in said housing so as to provide a substantially constant flow rate of said fluid through said fluid exit flow path.
9. An implantable infusion device according to claim 8 , wherein said propellant is disposed in said variable volume region of said bellows at a pressure which is not less than atmospheric pressure at ambient temperature.
10. An implantable infusion device according to claim 1 , wherein said bellows is made of a substantially rigid, gas-impermeable material.
11. An implantable infusion device according to claim 1 , wherein said bellows is hermetically sealed.
12. An implantable infusion device according to claim 1 , wherein said central portion of said bellows is offset from the plane of said annular peripheral portion of said bellows.
13. An implantable infusion device according to claim 12 , wherein a central region of said portion of said housing from which the bellows extends is correspondingly offset from the plane of the annular portion of the housing, wherein the offset central region of the housing substantially nests within said offset central portion of said bellows.
14. An implantable infusion device according to claim 1 , wherein the housing and bellows are cylindrical.
15. An implantable infusion device according to claim 1 , further comprising a separate bolus port in fluid communication with said fluid exit flow path.
16. An implantable infusion device according to claim 15 , further comprising a pair of septa disposed in said bolus port, wherein the septa are spaced apart to define a bolus reservoir therebetween, wherein a delivery needle having an opening near the center of its length is required to deliver infusate to the bolus reservoir.
17. An implantable infusion device according to claim 1 , wherein the bellows extends from the top portion of the housing.
18. An implantable infusion device according to claim 1 , wherein the bellows extends from the bottom portion of the housing.
19. An implantable infusion device, comprising:
A. a housing having (a) an annular portion with an inner wall defining an interior region having a width dimension D and extending along a central axis, (b) a bottom portion extending from said annular portion and spanning a first end of said interior region, and (c) a top portion extending from said annular portion and spanning a second end of said interior region, said top portion being opposite said bottom portion, wherein said interior region is substantially closed; and
B. a closed fluid-impermeable hollow bellows disposed about a variable volume region and having a top member, a bottom member, and a plurality of serially coupled annular members extending therebetween, wherein junctions of said coupled annular members are coupled with flexures, said bellows having a maximum outer width dimension D′ where D′ is less than D, wherein at least one of said top and bottom members includes a substantially planar annular peripheral portion disposed about a central portion, wherein a pressure source is contained within said variable volume region of said bellows, and wherein said bellows is disposed within said interior region of said housing with one of said top and bottom members facing and rigidly coupled to a corresponding portion of said housing, whereby said annular members of said bellows are spaced apart from said annular portion of said housing,
wherein said housing includes a recharging fluid flow path from points external to said housing to a region adjacent to said central portion of one of said top and bottom members of said bellows, and wherein the region of coupling between said housing and said bellows defines a fluid dispersal flow path from said region adjacent to said central portion of said coupled member of said bellows to a region between said annular members of said bellows and said annular portion of said housing, and
wherein said housing further defines a fluid exit flow path extending from the region between said bellows and said annular portion of said housing to points external to said housing.
20. An implantable infusion device according to claim 19 , further comprising a pierceable, self-sealing septum disposed in said recharging fluid flow path.
21. An implantable infusion device according to claim 20 , wherein the septum is removable from the housing.
22. An implantable infusion device according to claim 19 , further comprising a recharging fluid reservoir disposed along said recharging fluid flow path.
23. An implantable infusion device according to claim 19 , further including at least one of a flow restrictor and a filter disposed along said fluid exit flow path.
24. An implantable infusion device according to claim 19 , wherein said housing is made of a gas-impermeable material.
25. An implantable infusion device according to claim 19 , wherein the pressure source comprises one or more of the group consisting of multiple-phase fluids, springs, shape memory metal alloys, Belville washers, and compressible materials.
26. An implantable infusion device according to claim 19 , wherein a multiple-phase fluid propellant is present in at least one of a liquid phase and a gas phase within said variable volume region of said bellows as a function of ambient temperature, wherein conversion of the propellant from a liquid phase to a gas phase increases the volume displaced by the bellows in the interior region of the housing, thereby exerting a force on a fluid external to said bellows in said housing so as to provide a substantially constant flow rate of said fluid through said fluid exit flow path.
27. An implantable infusion device according to claim 26 , wherein said propellant is disposed in said variable volume region of said bellows at a pressure which is not less than atmospheric pressure at ambient temperature.
28. An implantable infusion device according to claim 19 , wherein said bellows is made of a substantially rigid, gas-impermeable material.
29. An implantable infusion device according to claim 19 , wherein said bellows is hermetically sealed.
30. An implantable infusion device according to claim 19 , wherein said central portion of at least one of the top and bottom members of said bellows is offset from the plane of said annular peripheral portion of said top and bottom members of said bellows.
31. An implantable infusion device according to claim 30 , wherein a central region of said portion of said housing coupled to the bellows is correspondingly offset from the plane of the annular portion of the housing, wherein the offset central region of said portion of the housing coupled to the bellows substantially nests within said central portion of the coupled portion of said bellows.
32. An implantable infusion device according to claim 19 , wherein the bellows is coupled to the top portion of the housing.
33. An implantable infusion device according to claim 19 , wherein the bellows is coupled to the bottom portion of the housing.
34. An implantable infusion device according to claim 19 , wherein the fluid dispersal flow path includes regions of increased surface contact area in the coupled region between the housing and the bellows.
35. An implantable infusion device according to claim 19 , wherein the housing and bellows are cylindrical.
36. An implantable infusion device according to claim 19 , further comprising a separate bolus port in fluid communication with said fluid exit flow path.
37. An implantable infusion device according to claim 36 , further comprising a pair of septa disposed in said bolus port, wherein the septa ape spaced apart to define a bolus reservoir therebetween, wherein a delivery needle having an opening near the center of its length is required to deliver infusate to the bolus reservoir.
38. An implantable infusion device, comprising:
A. a housing having (a) an annular portion with an inner wall defining an interior region having a width dimension D and extending along a central axis, (b) a bottom portion extending from said annular portion and spanning a first end of said interior region, and (c) a top portion extending from said annular portion and spanning a second end of said interior region, said top portion being opposite said bottom portion, wherein said interior region is substantially closed;
B. a closed fluid-impermeable hollow bellows extending from one of the top and bottom portions of the housing and defining a variable volume- region therein and having a plurality of serially coupled annular members extending between top and bottom portions of the bellows, wherein junctions of said coupled annular members are coupled with flexures, said bellows having a maximum outer width dimension D′ where D′ is less than D, wherein the portion of the housing from which the bellows extends includes a substantially planar annular peripheral portion disposed about a central portion, wherein a pressure source is contained within said variable volume region of said bellows, and wherein said bellows is disposed within said interior region of said housing and rigidly coupled to said portion of the housing from which the bellows extends, whereby said annular members of said bellows are spaced apart from said annular portion of said housing, wherein said housing includes a recharging fluid flow path from points external to said housing to a region adjacent to said central portion of said portion of said housing from which the bellows extends, and wherein said housing further defines a fluid exit flow path extending from the region between said bellows and said annular portion of said housing to points external to said housing; and
C. a separate bolus port in fluid communication with said fluid exit flow path, wherein said bolus port includes a pair of septa disposed therein and spaced apart to define a bolus reservoir therebetween, wherein a delivery needle having an opening near the center of its length is required to deliver infusate to the bolus reservoir.
39. An implantable infusion device, comprising:
A. a housing having (a) an annular portion with an inner wall defining an interior region having a width dimension D and extending along a central axis, (b) a bottom portion extending from said annular portion and spanning a first end of said interior region, and (c) a top portion extending from said annular portion and spanning a second end of said interior region, said top portion being opposite said bottom portion, wherein said interior region is substantially closed;
B. a closed fluid-impermeable hollow bellows disposed about a variable volume region and having a top member, a bottom member, and a plurality of serially coupled annular members extending therebetween, wherein junctions of said coupled annular members are coupled with flexures, said bellows having a maximum outer width dimension D′ where D′ is less than D, wherein at least one of said top and bottom members includes a substantially planar annular peripheral portion disposed about a central portion, wherein a pressure source is contained within said variable volume region of said bellows, and wherein said bellows is disposed within said interior region of said housing with one of said top and bottom members facing and rigidly coupled to a corresponding portion of said housing, whereby said annular members of said bellows are spaced apart from said annular portion of said housing, wherein said housing includes a recharging fluid flow path from points external to said housing to a region adjacent to said central portion of one of said top and bottom members of said bellows, and wherein the region of coupling between said housing and said bellows defines a fluid dispersal flow path from said region adjacent to said central portion of said coupled member of said bellows to a region between said annular members of said bellows and said annular portion of said housing, and wherein said housing further defines a fluid exit flow path extending from the region between said bellows and said annular portion of said housing to points external to said housing; and
C. a separate bolus port in fluid communication with said fluid exit flow path, wherein said bolus port includes a pair of septa disposed therein and spaced apart to define a bolus reservoir therebetween, wherein a delivery needle having an opening near the center of its length is required to deliver infusate to the bolus reservoir.
40. A septum replacement kit for an enclosed device which is sealed with a septum,
wherein the enclosed device defines a fluid reservoir, a fluid flow inlet and a fluid flow outlet, the kit comprising:
a compressible septum adapted to sealingly engage in the fluid flow inlet of the reservoir; and
a septum installation tool adapted to compress the septum to a nominal insertion size, maintain said nominal insertion size of said septum prior to installation of the septum, and install the septum in the fluid flow inlet of the reservoir.
41. A septum replacement kit according to claim 40 , wherein the septum installation tool comprises a tubular member adapted for insertion into the fluid flow inlet of the reservoir, an opening in the tubular member for insertion and retention of said septum therein, and a plunger member disposable in said tubular member for expulsion of said septum from the tubular member, wherein insertion of the septum into the tubular member compresses the septum, and wherein expulsion of the septum from the tubular member into the fluid inlet reservoir permits the septum to expand to fill in and seal the fluid inlet reservoir.
42. A septum replacement kit according to claim 40 , wherein the septum is made of a self-sealing elastomeric material.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/869,978 US20040249363A1 (en) | 2000-01-11 | 2004-06-17 | Implantable, refillable infusion device and septum replacement kit |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/481,298 US6764472B1 (en) | 2000-01-11 | 2000-01-11 | Implantable refillable infusion device |
US10/869,978 US20040249363A1 (en) | 2000-01-11 | 2004-06-17 | Implantable, refillable infusion device and septum replacement kit |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/481,298 Continuation US6764472B1 (en) | 2000-01-11 | 2000-01-11 | Implantable refillable infusion device |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040249363A1 true US20040249363A1 (en) | 2004-12-09 |
Family
ID=23911409
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/481,298 Expired - Lifetime US6764472B1 (en) | 2000-01-11 | 2000-01-11 | Implantable refillable infusion device |
US10/169,821 Expired - Lifetime US7108686B2 (en) | 2000-01-11 | 2001-01-11 | Implantable, refillable infusion device and septum replacement kit |
US10/869,978 Abandoned US20040249363A1 (en) | 2000-01-11 | 2004-06-17 | Implantable, refillable infusion device and septum replacement kit |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/481,298 Expired - Lifetime US6764472B1 (en) | 2000-01-11 | 2000-01-11 | Implantable refillable infusion device |
US10/169,821 Expired - Lifetime US7108686B2 (en) | 2000-01-11 | 2001-01-11 | Implantable, refillable infusion device and septum replacement kit |
Country Status (8)
Country | Link |
---|---|
US (3) | US6764472B1 (en) |
EP (1) | EP1253957B1 (en) |
AT (1) | ATE345828T1 (en) |
AU (1) | AU781796B2 (en) |
CA (1) | CA2392164C (en) |
DE (1) | DE60124671T2 (en) |
ES (1) | ES2277604T3 (en) |
WO (1) | WO2001051108A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050165384A1 (en) * | 2002-02-18 | 2005-07-28 | Danfoss A/S | Device for administering of medication in gluid form |
US20070043335A1 (en) * | 2005-07-22 | 2007-02-22 | Medtronic, Inc. | Miniature pump for drug delivery |
WO2008045308A2 (en) * | 2006-10-05 | 2008-04-17 | Kumar Anil B | Balloon catheter with manually operated valve and aspirator |
US7914499B2 (en) | 2006-03-30 | 2011-03-29 | Valeritas, Inc. | Multi-cartridge fluid delivery device |
US8070726B2 (en) | 2003-04-23 | 2011-12-06 | Valeritas, Inc. | Hydraulically actuated pump for long duration medicament administration |
US8876795B2 (en) | 2011-02-02 | 2014-11-04 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US9046192B2 (en) * | 2007-01-31 | 2015-06-02 | The Charles Stark Draper Laboratory, Inc. | Membrane-based fluid control in microfluidic devices |
US9089636B2 (en) | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
US9180054B2 (en) | 2004-01-29 | 2015-11-10 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US9211378B2 (en) | 2010-10-22 | 2015-12-15 | Cequr Sa | Methods and systems for dosing a medicament |
WO2019165342A1 (en) * | 2018-02-26 | 2019-08-29 | Primo Medical Group, Inc. | Variable volume infusion port |
US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11185677B2 (en) | 2017-06-07 | 2021-11-30 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
US11964145B2 (en) | 2020-07-13 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8177762B2 (en) | 1998-12-07 | 2012-05-15 | C. R. Bard, Inc. | Septum including at least one identifiable feature, access ports including same, and related methods |
US6471635B1 (en) | 2000-02-10 | 2002-10-29 | Obtech Medical Ag | Anal incontinence disease treatment with controlled wireless energy supply |
US6482145B1 (en) | 2000-02-14 | 2002-11-19 | Obtech Medical Ag | Hydraulic anal incontinence treatment |
US6464628B1 (en) | 1999-08-12 | 2002-10-15 | Obtech Medical Ag | Mechanical anal incontinence |
US6450173B1 (en) | 1999-08-12 | 2002-09-17 | Obtech Medical Ag | Heartburn and reflux disease treatment with controlled wireless energy supply |
US6764472B1 (en) * | 2000-01-11 | 2004-07-20 | Bard Access Systems, Inc. | Implantable refillable infusion device |
BR0108225B1 (en) | 2000-02-10 | 2010-02-09 | apparatus for the treatment of urinary incontinence. | |
BR0108223B1 (en) | 2000-02-10 | 2009-08-11 | mechanical apparatus for the treatment of impotence. | |
DE60113965T2 (en) | 2000-02-10 | 2006-07-06 | Potencia Medical Ag | TREATMENT OF HARNINE CONTINENCE WITH WIRELESS ENERGY SUPPLY |
DE60131726T2 (en) | 2000-02-11 | 2008-11-06 | Potencia Medical Ag | CONTROLLED IMPOTENA TREATMENT |
CN101138528B (en) | 2000-02-11 | 2015-02-25 | 波坦蒂卡股份公司 | Impotence treatment apparatus with energy transforming means |
DE60111019T2 (en) | 2000-02-14 | 2006-05-11 | Potencia Medical Ag | PROSTHESIS |
AU778113B2 (en) | 2000-02-14 | 2004-11-18 | Implantica Patent Ltd. | Male impotence prosthesis apparatus with wireless energy supply |
US20030100929A1 (en) | 2000-02-14 | 2003-05-29 | Peter Forsell | Controlled penile prosthesis |
US6712772B2 (en) * | 2001-11-29 | 2004-03-30 | Biocontrol Medical Ltd. | Low power consumption implantable pressure sensor |
US20040143221A1 (en) * | 2002-12-27 | 2004-07-22 | Shadduck John H. | Biomedical implant for sustained agent release |
US8946151B2 (en) * | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
US20040204692A1 (en) * | 2003-04-11 | 2004-10-14 | Kenneth Eliasen | Implantable vascular access device |
US7963956B2 (en) * | 2003-04-22 | 2011-06-21 | Antisense Pharma Gmbh | Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique |
US20050267422A1 (en) * | 2004-05-26 | 2005-12-01 | Kriesel Marshall S | Fluid delivery apparatus |
US20070156090A1 (en) * | 2004-05-26 | 2007-07-05 | Kriesel Marshall S | Fluid delivery apparatus |
US7601162B2 (en) | 2005-01-14 | 2009-10-13 | Ethicon Endo-Surgery, Inc. | Actuator for an implantable band |
US7879068B2 (en) | 2005-01-14 | 2011-02-01 | Ethicon Endo-Surgery, Inc. | Feedback sensing for a mechanical restrictive device |
EP1861161A4 (en) * | 2005-01-24 | 2012-05-16 | Neurosystec Corp | Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues |
US9474888B2 (en) | 2005-03-04 | 2016-10-25 | C. R. Bard, Inc. | Implantable access port including a sandwiched radiopaque insert |
EP1858565B1 (en) | 2005-03-04 | 2021-08-11 | C.R. Bard, Inc. | Access port identification systems and methods |
US7947022B2 (en) | 2005-03-04 | 2011-05-24 | C. R. Bard, Inc. | Access port identification systems and methods |
US8029482B2 (en) | 2005-03-04 | 2011-10-04 | C. R. Bard, Inc. | Systems and methods for radiographically identifying an access port |
WO2006116613A1 (en) | 2005-04-27 | 2006-11-02 | C.R. Bard, Inc. | Infusion apparatuses |
US10307581B2 (en) | 2005-04-27 | 2019-06-04 | C. R. Bard, Inc. | Reinforced septum for an implantable medical device |
EP2324880B1 (en) | 2005-04-27 | 2014-12-24 | C.R. Bard, Inc. | Infusion apparatuses provided with septum |
US8211060B2 (en) | 2005-05-10 | 2012-07-03 | Palyon Medical (Bvi) Limited | Reduced size implantable pump |
US7637892B2 (en) | 2005-05-10 | 2009-12-29 | Palyon Medical (Bvi) Limited | Variable flow infusion pump system |
US8915893B2 (en) | 2005-05-10 | 2014-12-23 | Palyon Medical (Bvi) Limited | Variable flow infusion pump system |
US8114055B2 (en) | 2005-05-10 | 2012-02-14 | Palyon Medical (Bvi) Limited | Implantable pump with infinitely variable resistor |
US8034030B2 (en) * | 2005-05-25 | 2011-10-11 | Palyon Medical (Bvi) Limited | Multi-reservoir implantable pump with variable flow rate capabilities |
WO2006126201A2 (en) * | 2005-05-26 | 2006-11-30 | Biocontrol Medical, Ltd. | Suture loops for implantable device |
US9687186B2 (en) | 2005-07-21 | 2017-06-27 | Steadymed Ltd. | Drug delivery device |
IL175460A (en) | 2006-05-07 | 2011-05-31 | Doron Aurbach | Drug delivery device |
US8186358B2 (en) * | 2005-07-29 | 2012-05-29 | Codman Neuro Sciences Sárl | System and method for locating an internal device in a closed system |
EP2926847B1 (en) * | 2005-11-02 | 2022-05-25 | MedicalTree Patents Ltd. | Implantable infusion device with advanceable and retractable needle |
US7722580B2 (en) * | 2005-11-02 | 2010-05-25 | Navilyst Medical, Inc. | Percutaneous access port |
US7708730B2 (en) | 2006-01-30 | 2010-05-04 | Palyon Medical (Bvi) Limited | Template system for multi-reservoir implantable pump |
CN109621078B (en) | 2006-02-09 | 2022-05-27 | 德卡产品有限公司 | System for controlling a wearable medical device |
US8870742B2 (en) | 2006-04-06 | 2014-10-28 | Ethicon Endo-Surgery, Inc. | GUI for an implantable restriction device and a data logger |
US8267905B2 (en) | 2006-05-01 | 2012-09-18 | Neurosystec Corporation | Apparatus and method for delivery of therapeutic and other types of agents |
JP4819581B2 (en) * | 2006-06-02 | 2011-11-24 | 富士フイルム株式会社 | Liquid storage device and image forming apparatus |
US7803148B2 (en) | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
US9308325B2 (en) * | 2006-06-19 | 2016-04-12 | Corium International, Inc. | Methods, devices, and kits for microjet drug delivery |
US9642986B2 (en) | 2006-11-08 | 2017-05-09 | C. R. Bard, Inc. | Resource information key for an insertable medical device |
US9265912B2 (en) | 2006-11-08 | 2016-02-23 | C. R. Bard, Inc. | Indicia informative of characteristics of insertable medical devices |
KR100867271B1 (en) * | 2007-03-09 | 2008-11-06 | 고려대학교 산학협력단 | Drug reservoir for implantable drug infusioin pump and the implantable drug infusion comprising the drug reservoir and the manufacturing method thereof |
US8603050B2 (en) * | 2007-06-07 | 2013-12-10 | The Alfred E. Mann Foundation For Scientific Research | Implantable infusion devices including apparatus for confirming side port access |
EP2164559B1 (en) | 2007-06-20 | 2017-10-25 | Medical Components, Inc. | Venous access port with molded and/or radiopaque indicia |
CA2693972C (en) | 2007-07-19 | 2019-01-15 | Medical Components, Inc. | Venous access port assembly with x-ray discernable indicia |
US9610432B2 (en) | 2007-07-19 | 2017-04-04 | Innovative Medical Devices, Llc | Venous access port assembly with X-ray discernable indicia |
US9579496B2 (en) | 2007-11-07 | 2017-02-28 | C. R. Bard, Inc. | Radiopaque and septum-based indicators for a multi-lumen implantable port |
US8100870B2 (en) * | 2007-12-14 | 2012-01-24 | Ethicon Endo-Surgery, Inc. | Adjustable height gastric restriction devices and methods |
US8636670B2 (en) | 2008-05-13 | 2014-01-28 | The Invention Science Fund I, Llc | Circulatory monitoring systems and methods |
US20090287120A1 (en) | 2007-12-18 | 2009-11-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
US9717896B2 (en) | 2007-12-18 | 2017-08-01 | Gearbox, Llc | Treatment indications informed by a priori implant information |
EP2244758A4 (en) * | 2008-01-28 | 2016-12-14 | Kirk Promotion Ltd | A drainage device comprising an active filter |
US8551044B2 (en) * | 2008-03-05 | 2013-10-08 | Flowonix Medical Incorporated | Multiple reservoir implantable drug infusion device and method |
US8369942B2 (en) * | 2008-03-20 | 2013-02-05 | The Invention Science Fund I, Llc | Subdermal material delivery device |
JP5050982B2 (en) * | 2008-04-24 | 2012-10-17 | セイコーエプソン株式会社 | Fluid ejection device and surgical scalpel |
US9180282B2 (en) * | 2008-09-05 | 2015-11-10 | Flowonix Medical Incorporated | Implantable drug delivery system having periodic drug delivery regimen to avoid granulomas |
CA2776467A1 (en) | 2008-10-10 | 2010-04-15 | Peter Forsell | Fastening means for implantable medical control assembly |
SI2349383T1 (en) | 2008-10-10 | 2022-02-28 | Medicaltree Patent Ltd. | Heart help device and system |
US10219898B2 (en) | 2008-10-10 | 2019-03-05 | Peter Forsell | Artificial valve |
WO2010042018A1 (en) | 2008-10-10 | 2010-04-15 | Milux Holding S.A. | Heart help device, system and method |
US9526649B2 (en) | 2008-10-10 | 2016-12-27 | Peter Forsell | Method and instrument for treating obesity |
EP2349025B1 (en) | 2008-10-10 | 2015-09-16 | Kirk Promotion LTD. | A system, an apparatus, and a method for treating a sexual dysfunctional female patient |
EP2349170B1 (en) | 2008-10-10 | 2023-09-27 | Implantica Patent Ltd. | Apparatus for the treatment of female sexual dysfunction |
EP2334354A4 (en) * | 2008-10-15 | 2014-01-22 | Symbios Medical Products Llc | Electronic flow control |
ES2906416T3 (en) | 2008-10-31 | 2022-04-18 | Bard Inc C R | Systems and methods to identify an access road |
US11890443B2 (en) | 2008-11-13 | 2024-02-06 | C. R. Bard, Inc. | Implantable medical devices including septum-based indicators |
US8932271B2 (en) | 2008-11-13 | 2015-01-13 | C. R. Bard, Inc. | Implantable medical devices including septum-based indicators |
JP5826170B2 (en) * | 2009-05-20 | 2015-12-02 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Assemblies for use in drug delivery devices |
US8715244B2 (en) | 2009-07-07 | 2014-05-06 | C. R. Bard, Inc. | Extensible internal bolster for a medical device |
JP5859959B2 (en) * | 2009-07-10 | 2016-02-16 | ミルックス・ホールディング・エスエイ | Implantable lubrication device and method for treating a human or mammalian patient with the device |
US10952836B2 (en) | 2009-07-17 | 2021-03-23 | Peter Forsell | Vaginal operation method for the treatment of urinary incontinence in women |
US9949812B2 (en) | 2009-07-17 | 2018-04-24 | Peter Forsell | Vaginal operation method for the treatment of anal incontinence in women |
CN102612343B (en) | 2009-11-17 | 2015-11-25 | C·R·巴德股份有限公司 | Comprise the coated molded entry port of anchoring device and identification division |
US8380312B2 (en) | 2009-12-31 | 2013-02-19 | Ams Research Corporation | Multi-zone stimulation implant system and method |
JP6141764B2 (en) * | 2010-05-18 | 2017-06-07 | シー・アール・バード・インコーポレーテッドC R Bard Incorporated | Reinforced septum for implantable medical devices |
US9173994B2 (en) * | 2010-08-20 | 2015-11-03 | Purdue Research Foundation | Touch-actuated micropump for transdermal drug delivery and method of use |
US9737660B2 (en) | 2010-08-25 | 2017-08-22 | Medtronic, Inc. | Drug infusion device with controllable valve |
US10143796B2 (en) * | 2010-08-25 | 2018-12-04 | Medtronic, Inc. | Fluid delivery device refill access |
EP2621558B1 (en) * | 2010-09-27 | 2018-11-21 | Steadymed Ltd. | Size-efficient drug-delivery device |
USD682416S1 (en) | 2010-12-30 | 2013-05-14 | C. R. Bard, Inc. | Implantable access port |
USD676955S1 (en) | 2010-12-30 | 2013-02-26 | C. R. Bard, Inc. | Implantable access port |
US20120191074A1 (en) * | 2011-01-21 | 2012-07-26 | Palyon Medical (Bvi) Limited | Reduced sized programmable pump |
US20120215183A1 (en) * | 2011-02-22 | 2012-08-23 | Medtronic Minimed, Inc. | Fluid infusion device having a sealing assembly for a fluid reservoir |
EP2556815A1 (en) * | 2011-08-10 | 2013-02-13 | Debiotech S.A. | Container for storing a drug such as insulin |
US9731112B2 (en) | 2011-09-08 | 2017-08-15 | Paul J. Gindele | Implantable electrode assembly |
US10010667B2 (en) * | 2011-10-18 | 2018-07-03 | Medtronic, Inc. | Implantable infusion device including anti-sealing reservoir |
US8591456B2 (en) | 2011-12-28 | 2013-11-26 | Palyon Medical (Bvi) Limited | Multiple reservoir programmable pump |
US8568360B2 (en) | 2011-12-28 | 2013-10-29 | Palyon Medical (Bvi) Limited | Programmable implantable pump design |
WO2013136327A1 (en) | 2012-03-15 | 2013-09-19 | Steadymed Ltd. | Enhanced infusion-site pain-reduction for drug-delivery devices |
ES2715311T3 (en) | 2012-03-19 | 2019-06-03 | Steadymed Ltd | Fluid connection mechanism for patch type pumps |
EP2948121B1 (en) | 2013-01-23 | 2017-11-29 | C.R. Bard Inc. | Low-profile access port |
US11420033B2 (en) | 2013-01-23 | 2022-08-23 | C. R. Bard, Inc. | Low-profile single and dual vascular access device |
US11464960B2 (en) | 2013-01-23 | 2022-10-11 | C. R. Bard, Inc. | Low-profile single and dual vascular access device |
US10463847B2 (en) | 2015-06-11 | 2019-11-05 | Steadymed Ltd. | Infusion set |
NL2015004B1 (en) * | 2015-06-19 | 2017-01-24 | Ipadic B V | Implantable infusion system. |
US9758786B2 (en) | 2016-02-09 | 2017-09-12 | Autotelic, Llc | Compositions and methods for treating pancreatic cancer |
USD870264S1 (en) | 2017-09-06 | 2019-12-17 | C. R. Bard, Inc. | Implantable apheresis port |
US11583627B1 (en) | 2018-10-18 | 2023-02-21 | University Of South Florida | Implantable drug storage devices for drug delivery |
JP2023553202A (en) | 2020-12-08 | 2023-12-20 | ルミナント バイオテク コーポレーション リミテッド | Improvements in devices and methods for delivering substances to animals |
Citations (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3682315A (en) * | 1969-10-20 | 1972-08-08 | Wolfgang Haller | Cartridge type column for treatment of liquid streams and substrate enclosure therefor |
US3731681A (en) * | 1970-05-18 | 1973-05-08 | Univ Minnesota | Implantable indusion pump |
US3896806A (en) * | 1971-01-08 | 1975-07-29 | Ceskoslovenska Akademie Ved | Implant for directed infusion of biologically active substances |
US3971376A (en) * | 1973-02-26 | 1976-07-27 | Ceskoslovenska Akademie Ved | Method and apparatus for introducing fluids into the body |
US4146029A (en) * | 1974-04-23 | 1979-03-27 | Ellinwood Jr Everett H | Self-powered implanted programmable medication system and method |
US4193397A (en) * | 1977-12-01 | 1980-03-18 | Metal Bellows Corporation | Infusion apparatus and method |
US4221219A (en) * | 1978-07-31 | 1980-09-09 | Metal Bellows Corporation | Implantable infusion apparatus and method |
US4258711A (en) * | 1979-02-05 | 1981-03-31 | Metal Bellows Corporation | Infusion apparatus and method |
US4286584A (en) * | 1978-06-16 | 1981-09-01 | Infusaid Corporation | Septum locating apparatus |
US4299220A (en) * | 1979-05-03 | 1981-11-10 | The Regents Of The University Of Minnesota | Implantable drug infusion regulator |
US4360019A (en) * | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
US4368737A (en) * | 1980-07-07 | 1983-01-18 | Purdue Research Foundation | Implantable catheter |
US4373527A (en) * | 1979-04-27 | 1983-02-15 | The Johns Hopkins University | Implantable, programmable medication infusion system |
US4417888A (en) * | 1982-03-15 | 1983-11-29 | Renal Systems, Inc. | Percutaneous implant |
US4447237A (en) * | 1982-05-07 | 1984-05-08 | Dow Corning Corporation | Valving slit construction and cooperating assembly for penetrating the same |
US4464178A (en) * | 1981-11-25 | 1984-08-07 | Dalton Michael J | Method and apparatus for administration of fluids |
US4496343A (en) * | 1982-06-14 | 1985-01-29 | Infusaid Corporation | Infusate pump |
US4505710A (en) * | 1983-05-13 | 1985-03-19 | Collins Earl R | Implantable fluid dispensing system |
US4525165A (en) * | 1979-04-27 | 1985-06-25 | The Johns Hopkins University | Fluid handling system for medication infusion system |
US4543088A (en) * | 1983-11-07 | 1985-09-24 | American Hospital Supply Corporation | Self-sealing subcutaneous injection site |
US4552561A (en) * | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
US4573994A (en) * | 1979-04-27 | 1986-03-04 | The Johns Hopkins University | Refillable medication infusion apparatus |
US4576211A (en) * | 1984-02-24 | 1986-03-18 | Farmitalia Carlo Erba S.P.A. | Safety device for connection of a syringe with the mouth or opening of a bottle containing a drug or a small tube for drug delivery from the syringe |
US4588394A (en) * | 1984-03-16 | 1986-05-13 | Pudenz-Schulte Medical Research Corp. | Infusion reservoir and pump system |
US4604090A (en) * | 1983-11-22 | 1986-08-05 | Consolidated Controls Corporation | Compact implantable medication infusion device |
US4619652A (en) * | 1982-12-23 | 1986-10-28 | Alza Corporation | Dosage form for use in a body mounted pump |
US4655765A (en) * | 1984-06-01 | 1987-04-07 | Parker Hannifin Corporation | Fitting with prestressed septum |
US4673391A (en) * | 1983-05-31 | 1987-06-16 | Koichi Sakurai | Non-contact controlled micropump |
US4687468A (en) * | 1984-10-01 | 1987-08-18 | Cook, Incorporated | Implantable insulin administration device |
US4692146A (en) * | 1985-10-24 | 1987-09-08 | Cormed, Inc. | Multiple vascular access port |
US4692147A (en) * | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
US4695273A (en) * | 1986-04-08 | 1987-09-22 | I-Flow Corporation | Multiple needle holder and subcutaneous multiple channel infusion port |
US4718893A (en) * | 1986-02-03 | 1988-01-12 | University Of Minnesota | Pressure regulated implantable infusion pump |
US4731051A (en) * | 1979-04-27 | 1988-03-15 | The Johns Hopkins University | Programmable control means for providing safe and controlled medication infusion |
US4760837A (en) * | 1987-02-19 | 1988-08-02 | Inamed Development Company | Apparatus for verifying the position of needle tip within the injection reservoir of an implantable medical device |
US4781680A (en) * | 1987-03-02 | 1988-11-01 | Vir Engineering | Resealable injection site |
US4810246A (en) * | 1987-11-04 | 1989-03-07 | L. Vad Technology, Inc. | Disposable cell culture chamber with remote access |
US4820273A (en) * | 1988-03-01 | 1989-04-11 | Eaton Corporation | Implantable medication infusion device and bolus generator therefor |
US4826487A (en) * | 1987-05-04 | 1989-05-02 | Victory Engineering Company | Alignment button for stereotaxic plug and method of using the same |
US4832054A (en) * | 1986-07-07 | 1989-05-23 | Medical Engineering Corporation | Septum |
US4834713A (en) * | 1987-10-30 | 1989-05-30 | Best Industries, Inc. | Catheter buttons |
US4857053A (en) * | 1988-08-29 | 1989-08-15 | Dalton Michael J | Matrix septum |
US4871351A (en) * | 1984-09-28 | 1989-10-03 | Vladimir Feingold | Implantable medication infusion system |
US4892518A (en) * | 1987-12-04 | 1990-01-09 | Biocontrol Technology, Inc. | Hemodialysis |
US4904241A (en) * | 1986-10-16 | 1990-02-27 | Medical Engineering Corp. | Septum with a needle stop at the fluid transfer port |
US4922926A (en) * | 1987-10-16 | 1990-05-08 | Siemens Aktiengesellschaft | Arrangement for delivering medications in an implantable medical device |
US4931050A (en) * | 1988-04-13 | 1990-06-05 | Shiley Infusaid Inc. | Constant pressure variable flow pump |
US4955861A (en) * | 1988-04-21 | 1990-09-11 | Therex Corp. | Dual access infusion and monitoring system |
US5006115A (en) * | 1989-07-25 | 1991-04-09 | Medtronic, Inc. | Needle placement sensor |
US5009644A (en) * | 1989-07-25 | 1991-04-23 | Medtronic, Inc. | Needle placement verifier |
US5053031A (en) * | 1988-03-29 | 1991-10-01 | Baxter International Inc. | Pump infusion system |
US5061242A (en) * | 1989-07-18 | 1991-10-29 | Infusaid, Inc. | Adjustable implantable drug infusion system |
US5085656A (en) * | 1989-05-10 | 1992-02-04 | Annemarie Schlogl GmbH & Co. KG | Implantable device for the dosed administration of medicaments to the human body |
US5088983A (en) * | 1989-09-26 | 1992-02-18 | Infusaid, Inc. | Pressure regulator for implantable pump |
US5135497A (en) * | 1991-07-08 | 1992-08-04 | Baxter International Inc. | Large volume pressurized fluid dispenser |
US5135502A (en) * | 1987-12-03 | 1992-08-04 | Medfusion Inc. | Solid introducer for catheter to a port and method of use |
US5137529A (en) * | 1990-02-20 | 1992-08-11 | Pudenz-Schulte Medical Research Corporation | Injection port |
US5176653A (en) * | 1990-02-15 | 1993-01-05 | Joel Metals | Improvements to implantable vascular access devices |
US5176644A (en) * | 1990-11-29 | 1993-01-05 | Minimed Technologies, Ltd. | Medication infusion pump with improved liquid-vapor pressure reservoir |
US5180365A (en) * | 1990-03-01 | 1993-01-19 | Ensminger William D | Implantable infusion device |
US5201728A (en) * | 1991-05-03 | 1993-04-13 | Giampapa Vincent C | Subcutaneous implantable multiple-agent delivery system |
US5207644A (en) * | 1991-03-04 | 1993-05-04 | Strecker Ernst P | Device with implantable infusion chamber and a catheter extending therefrom |
US5281210A (en) * | 1992-09-18 | 1994-01-25 | Infusaid, Inc. | Accumulator for implantable pump |
US5318540A (en) * | 1990-04-02 | 1994-06-07 | Pharmetrix Corporation | Controlled release infusion device |
US5328465A (en) * | 1992-10-30 | 1994-07-12 | Medtronic, Inc. | Apparatus and method for limiting access to septum |
US5395324A (en) * | 1991-06-07 | 1995-03-07 | Anschutz + Co., GmbH | Apparatus for the reliable filling of the container of an infusion pump |
US5443450A (en) * | 1994-04-29 | 1995-08-22 | Medtronic, Inc. | Medication delivery device and method of construction |
US5445616A (en) * | 1994-04-29 | 1995-08-29 | Medtronic, Inc. | Medication delivery device and method of construction |
US5507737A (en) * | 1993-04-22 | 1996-04-16 | Siemens Elema Ab | Apparatus for determining the volume of a bellows reservoir for medication in an implantable infusion system |
US5527277A (en) * | 1990-03-01 | 1996-06-18 | Michigan Transtech Corporation | Implantable access devices |
US5527307A (en) * | 1994-04-01 | 1996-06-18 | Minimed Inc. | Implantable medication infusion pump with discharge side port |
US5551849A (en) * | 1994-04-29 | 1996-09-03 | Medtronic, Inc. | Medication delivery device and method of construction |
US5558640A (en) * | 1994-03-17 | 1996-09-24 | Siemens Aktiengesellschaft | System for infusion of medicine into the body of a patient |
US5607418A (en) * | 1995-08-22 | 1997-03-04 | Illinois Institute Of Technology | Implantable drug delivery apparatus |
US5637088A (en) * | 1995-09-14 | 1997-06-10 | Wenner; Donald E. | System for preventing needle displacement in subcutaneous venous access ports |
US5667504A (en) * | 1993-10-08 | 1997-09-16 | Baumann; Hans | Process for the adjustment of a switchable flow limiting apparatus, and an apparatus operating according to the process |
US5707361A (en) * | 1994-03-10 | 1998-01-13 | Siemens Aktiengesellscahaft | Implantable infusion system with a neutral pressure medication container |
US5722957A (en) * | 1995-03-17 | 1998-03-03 | Fresenius Ag | Implantable infusion pump |
US5752930A (en) * | 1995-04-28 | 1998-05-19 | Medtronic, Inc. | Implantable techniques for infusing equal volumes of agents to spaced sites |
US5785681A (en) * | 1997-02-25 | 1998-07-28 | Minimed Inc. | Flow rate controller for a medication infusion pump |
US5814019A (en) * | 1995-03-17 | 1998-09-29 | Fresenius Ag | Implantable infusion pump |
US5890271A (en) * | 1997-07-30 | 1999-04-06 | Davco Packing And Seals, Inc. | Insertion tool |
US5897528A (en) * | 1998-04-30 | 1999-04-27 | Medtronic, Inc. | Filtered intracerebroventricular or intraspinal access port with direct cerebrospinal fluid access |
US5928195A (en) * | 1996-01-31 | 1999-07-27 | Malamud; Daniel | Remote control drug delivery device |
US6039712A (en) * | 1997-11-04 | 2000-03-21 | Terence M. Fogarty | Implantable injection port |
US6048328A (en) * | 1998-02-02 | 2000-04-11 | Medtronic, Inc. | Implantable drug infusion device having an improved valve |
US6053891A (en) * | 1996-08-26 | 2000-04-25 | Decampli; William M. | Apparatus and methods for providing selectively adjustable blood flow through a vascular graft |
US6168575B1 (en) * | 1998-01-29 | 2001-01-02 | David Pyam Soltanpour | Method and apparatus for controlling intraocular pressure |
US6228050B1 (en) * | 1999-04-30 | 2001-05-08 | Medtronic Inc. | Overfill protection systems for implantable drug delivery devices |
US6238367B1 (en) * | 2000-04-28 | 2001-05-29 | Medtronic, Inc. | Electrical connector for transducer of implantable drug infusion device |
US6280416B1 (en) * | 1999-02-19 | 2001-08-28 | Minimed Inc. | Constant flow medication infusion pump |
US6283949B1 (en) * | 1999-12-27 | 2001-09-04 | Advanced Cardiovascular Systems, Inc. | Refillable implantable drug delivery pump |
US6283943B1 (en) * | 1999-02-19 | 2001-09-04 | Minimed Inc. | Negative pressure pump |
US20030082507A1 (en) * | 2001-10-31 | 2003-05-01 | Stypulkowski Paul H. | System and method of treating stuttering by neuromodulation |
US20030088236A1 (en) * | 1999-03-18 | 2003-05-08 | Johnson Randolph Mellus | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
US6572583B1 (en) * | 2000-04-28 | 2003-06-03 | Medtronic, Inc. | Bulkhead for implantable infusion device |
US6589198B1 (en) * | 1998-01-29 | 2003-07-08 | David Soltanpour | Implantable micro-pump assembly |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS506630B1 (en) | 1971-02-01 | 1975-03-15 | ||
US3840009A (en) | 1971-12-27 | 1974-10-08 | Alza Corp | Self-powered vapor pressure delivery device |
US3951147A (en) | 1975-04-07 | 1976-04-20 | Metal Bellows Company | Implantable infusate pump |
SE413345B (en) | 1977-03-07 | 1980-05-19 | Gambro Ab | DEVICE INTENDED FOR INJECTION AND / OR SAMPLING THROUGH AN ELASTIC WALL |
US4490137A (en) | 1982-09-30 | 1984-12-25 | Moukheibir Nabil W | Surgically implantable peritoneal dialysis apparatus |
US4784645A (en) | 1982-11-04 | 1988-11-15 | The Johns Hopkins University | Apparatus for detecting a condition of a medication infusion system and providing an informational signal in response thereto |
DE3641107A1 (en) | 1985-12-03 | 1987-06-11 | Vladimir Feingold | SUBCUTANEOUS INPUT DEVICE |
US4710174A (en) | 1985-12-16 | 1987-12-01 | Surgical Engineering Associates, Inc. | Implantable infusion port |
US4714462A (en) | 1986-02-03 | 1987-12-22 | Intermedics Infusaid, Inc. | Positive pressure programmable infusion pump |
US4886501A (en) | 1987-08-25 | 1989-12-12 | Shiley Infusaid Inc. | Implantable device |
CA1333144C (en) | 1988-03-29 | 1994-11-22 | Baxter Travenol Laboratories, Inc. | Implantable drug delivery system |
US4978338A (en) | 1988-04-21 | 1990-12-18 | Therex Corp. | Implantable infusion apparatus |
AT391416B (en) | 1988-06-23 | 1990-10-10 | Annemarie Schloegl Ges M B H M | SEPTUM FOR IMPLANTABLE DEVICES FOR DELIVERING ACTIVE SUBSTANCES |
US5167638A (en) | 1989-10-27 | 1992-12-01 | C. R. Bard, Inc. | Subcutaneous multiple-access port |
US5045064A (en) | 1990-06-01 | 1991-09-03 | Infusaid, Inc. | Constant pressure implantable pump reservoir |
US5167625A (en) | 1990-10-09 | 1992-12-01 | Sarcos Group | Multiple vesicle implantable drug delivery system |
US5167633A (en) | 1990-11-29 | 1992-12-01 | Pacesetter Infusion, Ltd. | Liquid-vapor pressure reservoir for medication infusion pump |
US5290240A (en) | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
US5514103A (en) | 1994-06-14 | 1996-05-07 | Minimed Inc. | Medication infusion pump with improved pressure reservoir |
IE70735B1 (en) | 1994-08-15 | 1996-12-11 | Elan Med Tech | Orally administrable delivery device |
DE4432991C1 (en) | 1994-09-16 | 1995-10-26 | Fresenius Ag | Infusion pump for dispensing medicines into human body |
US5769823A (en) | 1995-03-23 | 1998-06-23 | Tricumed Gmbh | Implantable infusion pump |
US5575770A (en) * | 1995-04-05 | 1996-11-19 | Therex Corporation | Implantable drug infusion system with safe bolus capability |
US5908414A (en) | 1995-05-03 | 1999-06-01 | Tricumed Gmbh | Implantable infusion pump |
US5695490A (en) | 1995-06-07 | 1997-12-09 | Strato/Infusaid, Inc. | Implantable treatment material device |
US5776103A (en) | 1995-10-11 | 1998-07-07 | Science Incorporated | Fluid delivery device with bolus injection site |
US5976109A (en) | 1996-04-30 | 1999-11-02 | Medtronic, Inc. | Apparatus for drug infusion implanted within a living body |
DE19635056C2 (en) * | 1996-08-30 | 1998-07-02 | Tricumed Gmbh | Infusion pump |
US6169575B1 (en) * | 1996-09-26 | 2001-01-02 | Flashpoint Technology, Inc. | Method and system for controlled time-based image group formation |
DE19706139C1 (en) | 1997-02-18 | 1998-10-01 | Tricumed Gmbh | Implantable double injection port |
US5957890A (en) | 1997-06-09 | 1999-09-28 | Minimed Inc. | Constant flow medication infusion pump |
US6152898A (en) | 1999-04-30 | 2000-11-28 | Medtronic, Inc. | Overfill protection systems for implantable drug delivery devices |
US6764472B1 (en) * | 2000-01-11 | 2004-07-20 | Bard Access Systems, Inc. | Implantable refillable infusion device |
US6645176B1 (en) | 2000-04-28 | 2003-11-11 | Medtronic, Inc. | Spring loaded implantable drug infusion device |
US6485464B1 (en) | 2000-04-28 | 2002-11-26 | Medtronic, Inc. | Reduced height implantable drug infusion device |
-
2000
- 2000-01-11 US US09/481,298 patent/US6764472B1/en not_active Expired - Lifetime
-
2001
- 2001-01-11 WO PCT/US2001/000846 patent/WO2001051108A1/en active IP Right Grant
- 2001-01-11 EP EP01901975A patent/EP1253957B1/en not_active Expired - Lifetime
- 2001-01-11 AU AU27825/01A patent/AU781796B2/en not_active Ceased
- 2001-01-11 DE DE60124671T patent/DE60124671T2/en not_active Expired - Lifetime
- 2001-01-11 US US10/169,821 patent/US7108686B2/en not_active Expired - Lifetime
- 2001-01-11 CA CA002392164A patent/CA2392164C/en not_active Expired - Fee Related
- 2001-01-11 ES ES01901975T patent/ES2277604T3/en not_active Expired - Lifetime
- 2001-01-11 AT AT01901975T patent/ATE345828T1/en not_active IP Right Cessation
-
2004
- 2004-06-17 US US10/869,978 patent/US20040249363A1/en not_active Abandoned
Patent Citations (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3682315A (en) * | 1969-10-20 | 1972-08-08 | Wolfgang Haller | Cartridge type column for treatment of liquid streams and substrate enclosure therefor |
US3731681A (en) * | 1970-05-18 | 1973-05-08 | Univ Minnesota | Implantable indusion pump |
US3896806A (en) * | 1971-01-08 | 1975-07-29 | Ceskoslovenska Akademie Ved | Implant for directed infusion of biologically active substances |
US3971376A (en) * | 1973-02-26 | 1976-07-27 | Ceskoslovenska Akademie Ved | Method and apparatus for introducing fluids into the body |
US4146029A (en) * | 1974-04-23 | 1979-03-27 | Ellinwood Jr Everett H | Self-powered implanted programmable medication system and method |
US4193397A (en) * | 1977-12-01 | 1980-03-18 | Metal Bellows Corporation | Infusion apparatus and method |
US4286584A (en) * | 1978-06-16 | 1981-09-01 | Infusaid Corporation | Septum locating apparatus |
US4221219A (en) * | 1978-07-31 | 1980-09-09 | Metal Bellows Corporation | Implantable infusion apparatus and method |
US4258711A (en) * | 1979-02-05 | 1981-03-31 | Metal Bellows Corporation | Infusion apparatus and method |
US4360019A (en) * | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
US4373527A (en) * | 1979-04-27 | 1983-02-15 | The Johns Hopkins University | Implantable, programmable medication infusion system |
US4373527B1 (en) * | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
US4731051A (en) * | 1979-04-27 | 1988-03-15 | The Johns Hopkins University | Programmable control means for providing safe and controlled medication infusion |
US4525165A (en) * | 1979-04-27 | 1985-06-25 | The Johns Hopkins University | Fluid handling system for medication infusion system |
US4573994A (en) * | 1979-04-27 | 1986-03-04 | The Johns Hopkins University | Refillable medication infusion apparatus |
US4299220A (en) * | 1979-05-03 | 1981-11-10 | The Regents Of The University Of Minnesota | Implantable drug infusion regulator |
US4692147A (en) * | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
US4368737A (en) * | 1980-07-07 | 1983-01-18 | Purdue Research Foundation | Implantable catheter |
US4464178A (en) * | 1981-11-25 | 1984-08-07 | Dalton Michael J | Method and apparatus for administration of fluids |
US4417888A (en) * | 1982-03-15 | 1983-11-29 | Renal Systems, Inc. | Percutaneous implant |
US4447237A (en) * | 1982-05-07 | 1984-05-08 | Dow Corning Corporation | Valving slit construction and cooperating assembly for penetrating the same |
US4496343A (en) * | 1982-06-14 | 1985-01-29 | Infusaid Corporation | Infusate pump |
US4552561A (en) * | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
US4619652A (en) * | 1982-12-23 | 1986-10-28 | Alza Corporation | Dosage form for use in a body mounted pump |
US4505710A (en) * | 1983-05-13 | 1985-03-19 | Collins Earl R | Implantable fluid dispensing system |
US4673391A (en) * | 1983-05-31 | 1987-06-16 | Koichi Sakurai | Non-contact controlled micropump |
US4543088A (en) * | 1983-11-07 | 1985-09-24 | American Hospital Supply Corporation | Self-sealing subcutaneous injection site |
US4604090A (en) * | 1983-11-22 | 1986-08-05 | Consolidated Controls Corporation | Compact implantable medication infusion device |
US4576211A (en) * | 1984-02-24 | 1986-03-18 | Farmitalia Carlo Erba S.P.A. | Safety device for connection of a syringe with the mouth or opening of a bottle containing a drug or a small tube for drug delivery from the syringe |
US4588394A (en) * | 1984-03-16 | 1986-05-13 | Pudenz-Schulte Medical Research Corp. | Infusion reservoir and pump system |
US4655765A (en) * | 1984-06-01 | 1987-04-07 | Parker Hannifin Corporation | Fitting with prestressed septum |
US4871351A (en) * | 1984-09-28 | 1989-10-03 | Vladimir Feingold | Implantable medication infusion system |
US4687468A (en) * | 1984-10-01 | 1987-08-18 | Cook, Incorporated | Implantable insulin administration device |
US4692146A (en) * | 1985-10-24 | 1987-09-08 | Cormed, Inc. | Multiple vascular access port |
US4718893A (en) * | 1986-02-03 | 1988-01-12 | University Of Minnesota | Pressure regulated implantable infusion pump |
US4695273A (en) * | 1986-04-08 | 1987-09-22 | I-Flow Corporation | Multiple needle holder and subcutaneous multiple channel infusion port |
US4832054A (en) * | 1986-07-07 | 1989-05-23 | Medical Engineering Corporation | Septum |
US4904241A (en) * | 1986-10-16 | 1990-02-27 | Medical Engineering Corp. | Septum with a needle stop at the fluid transfer port |
US4760837A (en) * | 1987-02-19 | 1988-08-02 | Inamed Development Company | Apparatus for verifying the position of needle tip within the injection reservoir of an implantable medical device |
US4781680A (en) * | 1987-03-02 | 1988-11-01 | Vir Engineering | Resealable injection site |
US4826487A (en) * | 1987-05-04 | 1989-05-02 | Victory Engineering Company | Alignment button for stereotaxic plug and method of using the same |
US4922926A (en) * | 1987-10-16 | 1990-05-08 | Siemens Aktiengesellschaft | Arrangement for delivering medications in an implantable medical device |
US4834713A (en) * | 1987-10-30 | 1989-05-30 | Best Industries, Inc. | Catheter buttons |
US4810246A (en) * | 1987-11-04 | 1989-03-07 | L. Vad Technology, Inc. | Disposable cell culture chamber with remote access |
US5135502A (en) * | 1987-12-03 | 1992-08-04 | Medfusion Inc. | Solid introducer for catheter to a port and method of use |
US5248301A (en) * | 1987-12-03 | 1993-09-28 | Medfusion, Inc. | Transcutaneous infusion apparatus and methods of manufacture and use |
US4892518A (en) * | 1987-12-04 | 1990-01-09 | Biocontrol Technology, Inc. | Hemodialysis |
US4820273A (en) * | 1988-03-01 | 1989-04-11 | Eaton Corporation | Implantable medication infusion device and bolus generator therefor |
US5053031A (en) * | 1988-03-29 | 1991-10-01 | Baxter International Inc. | Pump infusion system |
US4931050A (en) * | 1988-04-13 | 1990-06-05 | Shiley Infusaid Inc. | Constant pressure variable flow pump |
US4955861A (en) * | 1988-04-21 | 1990-09-11 | Therex Corp. | Dual access infusion and monitoring system |
US4857053A (en) * | 1988-08-29 | 1989-08-15 | Dalton Michael J | Matrix septum |
US5085656A (en) * | 1989-05-10 | 1992-02-04 | Annemarie Schlogl GmbH & Co. KG | Implantable device for the dosed administration of medicaments to the human body |
US5061242A (en) * | 1989-07-18 | 1991-10-29 | Infusaid, Inc. | Adjustable implantable drug infusion system |
US5006115A (en) * | 1989-07-25 | 1991-04-09 | Medtronic, Inc. | Needle placement sensor |
US5009644A (en) * | 1989-07-25 | 1991-04-23 | Medtronic, Inc. | Needle placement verifier |
US5088983A (en) * | 1989-09-26 | 1992-02-18 | Infusaid, Inc. | Pressure regulator for implantable pump |
US5176653A (en) * | 1990-02-15 | 1993-01-05 | Joel Metals | Improvements to implantable vascular access devices |
US5137529A (en) * | 1990-02-20 | 1992-08-11 | Pudenz-Schulte Medical Research Corporation | Injection port |
US5180365A (en) * | 1990-03-01 | 1993-01-19 | Ensminger William D | Implantable infusion device |
US5556381A (en) * | 1990-03-01 | 1996-09-17 | The Michigan Transtech Corporation | Implantable access devices |
US5527277A (en) * | 1990-03-01 | 1996-06-18 | Michigan Transtech Corporation | Implantable access devices |
US5318540A (en) * | 1990-04-02 | 1994-06-07 | Pharmetrix Corporation | Controlled release infusion device |
US5176644A (en) * | 1990-11-29 | 1993-01-05 | Minimed Technologies, Ltd. | Medication infusion pump with improved liquid-vapor pressure reservoir |
US5207644A (en) * | 1991-03-04 | 1993-05-04 | Strecker Ernst P | Device with implantable infusion chamber and a catheter extending therefrom |
US5201728A (en) * | 1991-05-03 | 1993-04-13 | Giampapa Vincent C | Subcutaneous implantable multiple-agent delivery system |
US5395324A (en) * | 1991-06-07 | 1995-03-07 | Anschutz + Co., GmbH | Apparatus for the reliable filling of the container of an infusion pump |
US5135497A (en) * | 1991-07-08 | 1992-08-04 | Baxter International Inc. | Large volume pressurized fluid dispenser |
US5281210A (en) * | 1992-09-18 | 1994-01-25 | Infusaid, Inc. | Accumulator for implantable pump |
US5328465A (en) * | 1992-10-30 | 1994-07-12 | Medtronic, Inc. | Apparatus and method for limiting access to septum |
US5507737A (en) * | 1993-04-22 | 1996-04-16 | Siemens Elema Ab | Apparatus for determining the volume of a bellows reservoir for medication in an implantable infusion system |
US5667504A (en) * | 1993-10-08 | 1997-09-16 | Baumann; Hans | Process for the adjustment of a switchable flow limiting apparatus, and an apparatus operating according to the process |
US5707361A (en) * | 1994-03-10 | 1998-01-13 | Siemens Aktiengesellscahaft | Implantable infusion system with a neutral pressure medication container |
US5558640A (en) * | 1994-03-17 | 1996-09-24 | Siemens Aktiengesellschaft | System for infusion of medicine into the body of a patient |
US5527307A (en) * | 1994-04-01 | 1996-06-18 | Minimed Inc. | Implantable medication infusion pump with discharge side port |
US5551849A (en) * | 1994-04-29 | 1996-09-03 | Medtronic, Inc. | Medication delivery device and method of construction |
US5445616A (en) * | 1994-04-29 | 1995-08-29 | Medtronic, Inc. | Medication delivery device and method of construction |
US5443450A (en) * | 1994-04-29 | 1995-08-22 | Medtronic, Inc. | Medication delivery device and method of construction |
US5814019A (en) * | 1995-03-17 | 1998-09-29 | Fresenius Ag | Implantable infusion pump |
US5722957A (en) * | 1995-03-17 | 1998-03-03 | Fresenius Ag | Implantable infusion pump |
US5752930A (en) * | 1995-04-28 | 1998-05-19 | Medtronic, Inc. | Implantable techniques for infusing equal volumes of agents to spaced sites |
US5607418A (en) * | 1995-08-22 | 1997-03-04 | Illinois Institute Of Technology | Implantable drug delivery apparatus |
US5637088A (en) * | 1995-09-14 | 1997-06-10 | Wenner; Donald E. | System for preventing needle displacement in subcutaneous venous access ports |
US5928195A (en) * | 1996-01-31 | 1999-07-27 | Malamud; Daniel | Remote control drug delivery device |
US6053891A (en) * | 1996-08-26 | 2000-04-25 | Decampli; William M. | Apparatus and methods for providing selectively adjustable blood flow through a vascular graft |
US5785681A (en) * | 1997-02-25 | 1998-07-28 | Minimed Inc. | Flow rate controller for a medication infusion pump |
US5890271A (en) * | 1997-07-30 | 1999-04-06 | Davco Packing And Seals, Inc. | Insertion tool |
US6039712A (en) * | 1997-11-04 | 2000-03-21 | Terence M. Fogarty | Implantable injection port |
US6168575B1 (en) * | 1998-01-29 | 2001-01-02 | David Pyam Soltanpour | Method and apparatus for controlling intraocular pressure |
US6589198B1 (en) * | 1998-01-29 | 2003-07-08 | David Soltanpour | Implantable micro-pump assembly |
US6048328A (en) * | 1998-02-02 | 2000-04-11 | Medtronic, Inc. | Implantable drug infusion device having an improved valve |
US5897528A (en) * | 1998-04-30 | 1999-04-27 | Medtronic, Inc. | Filtered intracerebroventricular or intraspinal access port with direct cerebrospinal fluid access |
US6280416B1 (en) * | 1999-02-19 | 2001-08-28 | Minimed Inc. | Constant flow medication infusion pump |
US6283943B1 (en) * | 1999-02-19 | 2001-09-04 | Minimed Inc. | Negative pressure pump |
US20030088236A1 (en) * | 1999-03-18 | 2003-05-08 | Johnson Randolph Mellus | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
US6228050B1 (en) * | 1999-04-30 | 2001-05-08 | Medtronic Inc. | Overfill protection systems for implantable drug delivery devices |
US6283949B1 (en) * | 1999-12-27 | 2001-09-04 | Advanced Cardiovascular Systems, Inc. | Refillable implantable drug delivery pump |
US6238367B1 (en) * | 2000-04-28 | 2001-05-29 | Medtronic, Inc. | Electrical connector for transducer of implantable drug infusion device |
US6572583B1 (en) * | 2000-04-28 | 2003-06-03 | Medtronic, Inc. | Bulkhead for implantable infusion device |
US20030082507A1 (en) * | 2001-10-31 | 2003-05-01 | Stypulkowski Paul H. | System and method of treating stuttering by neuromodulation |
Cited By (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050165384A1 (en) * | 2002-02-18 | 2005-07-28 | Danfoss A/S | Device for administering of medication in gluid form |
US7517335B2 (en) | 2002-02-18 | 2009-04-14 | Cequr Aps | Device for administering of medication in fluid form |
US8945064B2 (en) | 2002-02-18 | 2015-02-03 | Cequr Sa | Device for administering of medication in fluid form |
US20090054867A1 (en) * | 2002-02-18 | 2009-02-26 | Peter Gravesen | Device for Administering of Medication in Fluid Form |
US9072828B2 (en) | 2003-04-23 | 2015-07-07 | Valeritas, Inc. | Hydraulically actuated pump for long duration medicament administration |
US9511187B2 (en) | 2003-04-23 | 2016-12-06 | Valeritas, Inc. | Hydraulically actuated pump for fluid administration |
US9125983B2 (en) | 2003-04-23 | 2015-09-08 | Valeritas, Inc. | Hydraulically actuated pump for fluid administration |
US8070726B2 (en) | 2003-04-23 | 2011-12-06 | Valeritas, Inc. | Hydraulically actuated pump for long duration medicament administration |
US11642456B2 (en) | 2003-04-23 | 2023-05-09 | Mannkind Corporation | Hydraulically actuated pump for fluid administration |
US10525194B2 (en) | 2003-04-23 | 2020-01-07 | Valeritas, Inc. | Hydraulically actuated pump for fluid administration |
US9180054B2 (en) | 2004-01-29 | 2015-11-10 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US9089636B2 (en) | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
US20070043335A1 (en) * | 2005-07-22 | 2007-02-22 | Medtronic, Inc. | Miniature pump for drug delivery |
US7931643B2 (en) * | 2005-07-22 | 2011-04-26 | Medtronic, Inc. | Miniature pump for drug delivery |
US8821443B2 (en) | 2006-03-30 | 2014-09-02 | Valeritas, Inc. | Multi-cartridge fluid delivery device |
US10493199B2 (en) | 2006-03-30 | 2019-12-03 | Valeritas, Inc. | Multi-cartridge fluid delivery device |
US8361053B2 (en) | 2006-03-30 | 2013-01-29 | Valeritas, Inc. | Multi-cartridge fluid delivery device |
US7914499B2 (en) | 2006-03-30 | 2011-03-29 | Valeritas, Inc. | Multi-cartridge fluid delivery device |
US9687599B2 (en) | 2006-03-30 | 2017-06-27 | Valeritas, Inc. | Multi-cartridge fluid delivery device |
WO2008045308A3 (en) * | 2006-10-05 | 2009-09-11 | Kumar Anil B | Balloon catheter with manually operated valve and aspirator |
WO2008045308A2 (en) * | 2006-10-05 | 2008-04-17 | Kumar Anil B | Balloon catheter with manually operated valve and aspirator |
US9046192B2 (en) * | 2007-01-31 | 2015-06-02 | The Charles Stark Draper Laboratory, Inc. | Membrane-based fluid control in microfluidic devices |
US9651166B2 (en) | 2007-01-31 | 2017-05-16 | The Charles Stark Draper Laboratory, Inc. | Membrane-based fluid control in microfluidic devices |
US9211378B2 (en) | 2010-10-22 | 2015-12-15 | Cequr Sa | Methods and systems for dosing a medicament |
US9764121B2 (en) | 2011-02-02 | 2017-09-19 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US8876795B2 (en) | 2011-02-02 | 2014-11-04 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
US11717670B2 (en) | 2017-06-07 | 2023-08-08 | Shifamed Holdings, LLP | Intravascular fluid movement devices, systems, and methods of use |
US11185677B2 (en) | 2017-06-07 | 2021-11-30 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11229784B2 (en) | 2018-02-01 | 2022-01-25 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11260211B2 (en) | 2018-02-26 | 2022-03-01 | Primo Medical Group, Inc. | Variable volume infusion port |
WO2019165342A1 (en) * | 2018-02-26 | 2019-08-29 | Primo Medical Group, Inc. | Variable volume infusion port |
JP2021514736A (en) * | 2018-02-26 | 2021-06-17 | プリモ メディカル グループ,インコーポレイテッド | Variable volume infusion port |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
US11964145B2 (en) | 2020-07-13 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
Also Published As
Publication number | Publication date |
---|---|
EP1253957A1 (en) | 2002-11-06 |
AU781796B2 (en) | 2005-06-16 |
US20030208184A1 (en) | 2003-11-06 |
DE60124671T2 (en) | 2007-09-13 |
US6764472B1 (en) | 2004-07-20 |
WO2001051108A1 (en) | 2001-07-19 |
CA2392164A1 (en) | 2001-07-19 |
US7108686B2 (en) | 2006-09-19 |
ES2277604T3 (en) | 2007-07-16 |
CA2392164C (en) | 2009-03-10 |
ATE345828T1 (en) | 2006-12-15 |
DE60124671D1 (en) | 2007-01-04 |
EP1253957B1 (en) | 2006-11-22 |
AU2782501A (en) | 2001-07-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6764472B1 (en) | Implantable refillable infusion device | |
ES2300082T3 (en) | TRANSCUTANEOUS SUPPLY MEDIA. | |
US4634427A (en) | Implantable demand medication delivery assembly | |
US6478783B1 (en) | Anti-sludge medication ports and related methods | |
JP3127020B2 (en) | Pharmaceutical infusion pump, pressure reservoir and method of using the same | |
EP2015830B1 (en) | Infusion device and overfill protection mechanism for use with same | |
US5607418A (en) | Implantable drug delivery apparatus | |
KR101802548B1 (en) | Fluid delivery device needle retraciton mechanisms, cartridges and expandable hydraulic fluid seals | |
US4681560A (en) | Subcutaneous infusion reservoir and pump system | |
US4468220A (en) | Low flow constant rate pump | |
ES2673480T3 (en) | Multi-stage fluid supply device and method | |
EP0291612B1 (en) | Implantable pump. | |
WO1999065540A9 (en) | Medical infusion device with a source of controlled compliance | |
JPH0852222A (en) | Medicine injection pump with improved pressure reservoir | |
CN110958893B (en) | Drug delivery device | |
EP0177250A2 (en) | Implantable insulin administration device | |
JPH02131778A (en) | Discharging method for medicine introduced into body and its dosing method thereby | |
US20230201454A1 (en) | Implantable intrathecal drug delivery system for chronic pain control | |
JPH10248928A (en) | Medical fluid supply jig and priming device | |
CN115443161A (en) | Pressurized medicine injector with function of preventing exposure of medicine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: INSET TECHNOLOGIES INCORPORATED, NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:INFUMEDICS, INC.;REEL/FRAME:021701/0484 Effective date: 20081009 |