US20050192590A1 - Antimicrobial agent delivery system - Google Patents
Antimicrobial agent delivery system Download PDFInfo
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- US20050192590A1 US20050192590A1 US10/786,021 US78602104A US2005192590A1 US 20050192590 A1 US20050192590 A1 US 20050192590A1 US 78602104 A US78602104 A US 78602104A US 2005192590 A1 US2005192590 A1 US 2005192590A1
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- United States
- Prior art keywords
- hub
- delivery system
- delivery tube
- delivery
- intervention device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0082—Catheter tip comprising a tool
- A61M25/0084—Catheter tip comprising a tool being one or more injection needles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Definitions
- Embodiments of the present invention are directed to an improved system and method for delivering antimicrobial agents into catheters.
- Catheters have become widely used in modern medicine to provide one or more lumens into a patient's body through which a wide variety of procedures may be performed or fluids may be introduced or removed from the patient. Examples include catheters lumens through which minimally-invasive surgical procedures, such as angioplasty balloon deployment or tissue resection, may be performed, catheters for introducing therapeutic substances at desired sites within the patient, catheters for the removal and/or replacement of fluids, such has blood removal and replacement during hemodialysis, and catheters associated with activation of mechanisms for medical devices, such as activation of control cables or application of pneumatic pressure to inflate balloons or expand stents at target locations within the patient.
- minimally-invasive surgical procedures such as angioplasty balloon deployment or tissue resection
- catheters for introducing therapeutic substances at desired sites within the patient catheters for the removal and/or replacement of fluids, such has blood removal and replacement during hemodialysis
- catheters associated with activation of mechanisms for medical devices such as activation of control cables or application of pneumatic pressure to in
- central venous catheters characteristically, at an infected site a large number of microorganisms are adherent on the catheter, where there is an interaction between the pathogen and the catheter microsurface. Once so infected, the microorganisms adhere to the catheter and rapidly become encased in a polysaccharide matrix or biofilm which protects the microorganisms from the natural defenses of the host. While there have been recent developments of central venous catheters to attempt to reduce the incidence of nosocomial catheter-based infections, such as the use of catheters with liquid chlorohexidine and silver sulfadiazine, or with a combination of minocycline and rifampin, such infections have yet to be eliminated.
- antimicrobial agent-bearing intervention devices has been proposed for the management of nosocomial blood stream infections.
- Antimicrobial agents such as povidone-iodine, chlorhexidine, polymicrobial gel, isopropyl alcohol and hydrogen peroxide have long been used in medical practice as disinfectants, with iodine having been discovered to be one of the most effective antiseptics in the 1870s.
- iodine-bearing formulations have been developed that may be applied to, or incorporated into, medical devices to provide controlled in-situ release of iodine as an antimicrobial agent.
- an iodine-bearing polymeric rod that can be inserted into a catheter, where the rod delivers iodine to the catheter in order to manage catheter-based nosocomial bloodstream infections.
- an iodine-bearing polymeric intervention device is placed within an indwelling catheter.
- elemental iodine may be released to diffuse to the catheter wall, and if the catheter wall material is semi-permeable, to diffuse through the catheter wall to the exterior surface of the catheter.
- the iodine may be made available to eliminate micro-organisms on both the inner and outer micro-surfaces of the catheter.
- systems and methods of delivering antimicrobial agent-bearing intervention devices are provided for reduced handling and improved control of the intervention device.
- an antimicrobial agent delivery system includes an antimicrobial agent-bearing intervention device and a delivery tube containing the intervention device.
- the delivery tube facilitates manipulation of the intervention device.
- an antimicrobial agent delivery system in another embodiment, includes an antimicrobial agent-bearing rod, a delivery tube, and a hub.
- the delivery tube contains the rod, and the delivery tube facilitates manipulation of the rod.
- the hub is coupled to the rod, and movement of the hub ejects the rod from the delivery tube.
- the delivery tube may have a longitudinal partition and a hub opening, where the hub opening provides external access to the hub and the longitudinal partition guides the hub longitudinally.
- the hub is optionally disposed within the delivery tube.
- An extension arm may be connected to the hub and may extend through the hub opening. If desired, the extension arm may be connected to the hub at a tapered connection point, where the tapered connection point enables removal of the extension arm from the hub after ejection of the rod from the delivery tube.
- a method of fabricating an antimicrobial agent delivery system provides for coupling a hub to an antimicrobial agent-bearing rod.
- a longitudinal partition and a hub opening are formed in a delivery tube.
- the method further provides for disposing the rod within the delivery tube, where the hub opening provides external access to the catheter hub.
- FIG. 1A is a side view of an example a delivery tube according to one embodiment of the invention.
- FIG. 1B is a side view of an example of an antimicrobial agent delivery system before ejection according to one embodiment of the invention
- FIG. 1C is a side view of an example of an antimicrobial agent delivery system during ejection according to one embodiment of the invention.
- FIG. 2 is a side view of an example of antimicrobial agent delivery system according to another embodiment of the invention.
- FIG. 3 is a side view of an example of an antimicrobial agent delivery system having a multiple lumen geometry according to another embodiment of the invention.
- FIG. 4 is a side view of an example of an antimicrobial agent delivery system having a plunger according to another embodiment of the invention.
- FIG. 5A is a side view of an example of a tapered connection point between a hub and an extension arm according to an embodiment of the invention
- FIG. 5B is an end view of an alternative example of a tapered connection point between a hub and an extension arm according to another embodiment of the invention.
- FIG. 5C is a side view of a example of a non-tapered connection between a hub and an extension arm according to another embodiment of the invention.
- FIG. 6A is an end view of an example of a hub having surfaces defining one or more apertures that enable fluid transfer according to an embodiment of the invention
- FIG. 6B is an end view of another example of a hub having surfaces defining one or more apertures that enable fluid transfer according to another embodiment of the invention.
- FIGS. 7A and 7B are cut-away views of an example of a valve according to an embodiment of the invention.
- FIG. 8 is a flowchart of an example of a method of fabricating an antimicrobial agent delivery system according to one embodiment of the invention.
- FIGS. 1A-1C One embodiment of the present invention is illustrated in FIGS. 1A-1C .
- FIG. 1A shows a delivery tube 14 .
- the delivery tube 14 has a longitudinal partition, in this case a perforation 20 , and a hub opening 18 .
- the longitudinal partition may be perforated, as shown, pre-scored, a continuous slit, or any other configuration that enables the functioning as described below.
- FIGS. 1B and 1C show an antimicrobial agent delivery system 10 .
- the antimicrobial agent delivery system 10 includes an antimicrobial agent-bearing intervention device, such as rod 12 , and the delivery tube 14 .
- the antimicrobial agent-bearing intervention device may have any suitable geometry. For example, it may be a tube or have an irregular shape, etc.
- the delivery tube may have any suitable geometry. For example, it may have a cross-sectional geometry that is similar to or different from the cross-sectional geometry of the intervention device.
- the antimicrobial agent-bearing intervention device is a rod 12 is disposed within the delivery tube 14 .
- the delivery tube 14 facilitates manipulation of the rod 12 . That is, because the rod 12 is in the delivery tube 14 , the rod 12 can be moved by simply grasping the delivery tube 14 , without the need to handle the rod 12 itself.
- a hub 16 is coupled to the rod 12 .
- an extension arm 22 is coupled to the hub 16 .
- the extension arm 22 extends through the hub opening 18 .
- the operator can eject the rod 12 from the tube 14 by longitudinally moving the hub 16 via extension arm 22 .
- the hub opening 18 provides external access to the hub 16
- the perforation 20 guides the hub 16 longitudinally. Longitudinal movement of the hub 16 results in ejection of the rod 12 from the delivery tube 14 .
- the rod 12 can be removed from the delivery tube 14 for use with a catheter.
- FIG. 5A shows an embodiment in which the extension arm 22 a is tapered toward the point where it connects with the hub 16 a , such that the extension arm 22 a and the hub 16 a have a tapered connection point 24 a .
- the width of the extension arm 22 a is tapered.
- FIG. 5B shows an alternative embodiment in which the thickness of the extension arm 22 b is tapered toward the point where it connects with the hub 16 b , such that the extension arm 22 b and the hub 16 b have a tapered connection point 24 b .
- the tapered connection point 24 a or 24 b enables removal of the extension arm from the hub after ejection of the rod from the delivery tube 14 ( FIGS. 1A-1C ).
- the tapered connection may have other suitable configurations, or other types of geometries or structures may be used, to facilitate separation of the extension arm from the hub, if desired.
- the extension arm need not be tapered, as shown in FIG. 5C , leaving a non-tapered connection point 24 .
- a delivery system 31 includes an antimicrobial agent-bearing rod 26 and a delivery tube 32 .
- the antimicrobial agent-bearing rod 26 has a flex point 28 .
- a hub 30 is connected to the end of the antimicrobial agent-bearing rod and is disposed outside the delivery tube 32 . It should be noted that disposing the hub 30 outside the delivery tube 32 enables the delivery tube 32 to be reduced in size considerably.
- the illustrated delivery tube 32 has a longitudinal partition, where the partition is a continuous slit 34 rather than a perforation.
- the material of the delivery tube may be self-sealing.
- One such material would be thermoplastic polyurethane (TPU), which has a low durometer characteristic to provide a desired level of “tackiness” on the surfaces that define the slit 34 .
- TPU thermoplastic polyurethane
- the resulting slit 34 would provide a dynamic seal that can be broken and immediately re-sealed as the rod 26 is advanced through the delivery system 31 .
- FIG. 3 shows another alternative embodiment of an antimicrobial agent delivery system in which a delivery tube 36 has a multiple lumen geometry.
- the multiple lumen geometry is defined by a first tube 38 and a second tube 40 .
- An antimicrobial agent-bearing rod 42 is disposed within the first tube 38 .
- the rod 42 may be connected to a hub 44 that is disposed within the second tube 40 .
- the rod 42 may be connected to a hub disposed within the first tube 38 , and the hub may be connected to an extension arm that extends into the second tube 40 .
- the rod 42 connects to the hub 44 (or the extension arm projects) through a longitudinal partition 46 defined by surfaces in a wall 48 that connects the first tube 38 to the second tube 40 .
- the hub and rod can be advanced through the delivery tube 36 by manipulating an extension arm (not shown) along a longitudinal partition formed in the second tube 44 , by manipulating a plunger (not shown) into second tube 40 to act on the extension arm or hub, or by any other suitable actuation structure.
- a delivery system 50 includes a plunger 52 extending out of an end of a delivery tube 54 , where the plunger 52 is in contact with a hub 56 .
- the hub 56 is attached to an antimicrobial agent-bearing rod 58 .
- the delivery tube 54 has openings at both ends to accommodate the longitudinal movement of the plunger 52 as well as the rod 58 . It should be noted that this delivery system 50 does not require a longitudinal partition.
- FIG. 6A an end view of a hub is shown.
- the illustrated hub has surfaces defining one or more apertures 60 a that enable fluid transfer through the hub while the antimicrobial agent-bearing rod is installed in a catheter (not shown).
- FIG. 6B shows another possible configuration of apertures 60 b .
- the hub With the apertures, the hub enables flushing and aspiration to take place around the rod.
- the apertures can be readily included in hub 16 ( FIGS. 1A-1C ), hub 30 ( FIG. 2 ), hub 44 ( FIG. 3 ), and hub 56 ( FIG. 4 ).
- the outer surface of the above-described delivery tubes can include materials such as polyether block amide (PEBA), polyethylene, thermoplastic polyurethane (TPU), polyester elastomer, ionomer and thermoplastic vulcanizate to provide a relatively high surface texture. The result would be improved ergonomics and enhanced control.
- PEBA polyether block amide
- TPU thermoplastic polyurethane
- polyester elastomer polyester elastomer
- ionomer thermoplastic vulcanizate
- thermoplastic vulcanizate thermoplastic vulcanizate to provide a relatively high surface texture.
- the inner surface of the delivery tubes can include materials that are non-permeable to the particular antimicrobial agent being used.
- the inner surface of the delivery tube may include PET.
- FIGS. 7A and 7B show a valve 72 that can be incorporated into an anti-microbial agent delivery system such as any of the systems discussed above.
- Valve 72 is coupled to an open end of a delivery tube 74 , where the delivery tube 74 contains a hub 76 and rod 78 .
- the valve 72 attaches to the hub 76 and detaches from the delivery tube 74 when ejection of the rod 78 is complete.
- the valve 72 attached to the hub 76 as shown in FIG. 7B enables the flow of fluid to and from a catheter (not shown) to be restricted as desired.
- step 64 provides for coupling a hub to an antimicrobial agent-bearing rod.
- step 66 provides for extruding a delivery tube.
- Step 68 provides for forming a longitudinal partition and a hub opening in the delivery tube.
- Step 70 provides for disposing the rod within the delivery tube, where the hub opening provides external access to the hub.
- method 62 may further include the process of coupling an external arm to the hub, in which case the step of disposing the rod within the delivery tube would include having the extension arm extend through the hub opening.
- the rod may have a flex point, where the hub is disposed outside the delivery tube.
- a wide variety of cutting systems such as a laser cutting system or a mechanical cutting system, can be used to form the longitudinal partition and the hub opening at step 68 .
- step 64 may come after steps 66 or 68 .
Abstract
An antimicrobial agent delivery system and method are provided for an antimicrobial agent-bearing intervention device. A delivery tube contains the intervention device, where the delivery tube facilitates handling of the intervention device. In one example, the intervention device is a rod, and a hub is coupled to the rod. Longitudinal movement of the hub ejects the rod from the delivery tube.
Description
- Embodiments of the present invention are directed to an improved system and method for delivering antimicrobial agents into catheters.
- Catheters have become widely used in modern medicine to provide one or more lumens into a patient's body through which a wide variety of procedures may be performed or fluids may be introduced or removed from the patient. Examples include catheters lumens through which minimally-invasive surgical procedures, such as angioplasty balloon deployment or tissue resection, may be performed, catheters for introducing therapeutic substances at desired sites within the patient, catheters for the removal and/or replacement of fluids, such has blood removal and replacement during hemodialysis, and catheters associated with activation of mechanisms for medical devices, such as activation of control cables or application of pneumatic pressure to inflate balloons or expand stents at target locations within the patient.
- Inherent with the use of medical devices placed within a patient is the risk of infection from the medical device. While great strides have been made in the last century in preventing infection during surgical procedures, this risk has not been entirely eliminated. For example, it has been estimated that central venous catheters account for more than 90 percent of all nosocomial catheter-related blood stream infections.
- In the case of central venous catheters, characteristically, at an infected site a large number of microorganisms are adherent on the catheter, where there is an interaction between the pathogen and the catheter microsurface. Once so infected, the microorganisms adhere to the catheter and rapidly become encased in a polysaccharide matrix or biofilm which protects the microorganisms from the natural defenses of the host. While there have been recent developments of central venous catheters to attempt to reduce the incidence of nosocomial catheter-based infections, such as the use of catheters with liquid chlorohexidine and silver sulfadiazine, or with a combination of minocycline and rifampin, such infections have yet to be eliminated.
- The use of antimicrobial agent-bearing intervention devices has been proposed for the management of nosocomial blood stream infections. Antimicrobial agents such as povidone-iodine, chlorhexidine, polymicrobial gel, isopropyl alcohol and hydrogen peroxide have long been used in medical practice as disinfectants, with iodine having been discovered to be one of the most effective antiseptics in the 1870s. Recently, iodine-bearing formulations have been developed that may be applied to, or incorporated into, medical devices to provide controlled in-situ release of iodine as an antimicrobial agent. One potential application of such formulations is an iodine-bearing polymeric rod that can be inserted into a catheter, where the rod delivers iodine to the catheter in order to manage catheter-based nosocomial bloodstream infections. In this example, an iodine-bearing polymeric intervention device is placed within an indwelling catheter. As a result, elemental iodine may be released to diffuse to the catheter wall, and if the catheter wall material is semi-permeable, to diffuse through the catheter wall to the exterior surface of the catheter. Thus, the iodine may be made available to eliminate micro-organisms on both the inner and outer micro-surfaces of the catheter.
- Notwithstanding the advantages in catheter-based nosocomial blood stream infection management offered by the use of an iodine-bearing polymeric intervention device, installation or delivery of the device into the catheter presents a number of challenges. For example, during insertion into the catheter, it is highly desirable for the intervention device to remain sterile and, therefore, out of direct contact with equipment, hands, and any other non-sterile surfaces. In addition, due to the relatively low column strength of rod implementations of the intervention devices, control over the rod can be less than desired. There is therefore a need for a delivery system that provides sterility by reducing direct handling of antimicrobial agent-bearing intervention devices. There is also a need for a delivery system that enhances control over the insertion of the intervention device during insertion into the catheter lumen.
- In accordance with certain embodiments of the invention, systems and methods of delivering antimicrobial agent-bearing intervention devices are provided for reduced handling and improved control of the intervention device.
- In one embodiment, an antimicrobial agent delivery system includes an antimicrobial agent-bearing intervention device and a delivery tube containing the intervention device. The delivery tube facilitates manipulation of the intervention device.
- In another embodiment of the invention, an antimicrobial agent delivery system includes an antimicrobial agent-bearing rod, a delivery tube, and a hub. The delivery tube contains the rod, and the delivery tube facilitates manipulation of the rod. The hub is coupled to the rod, and movement of the hub ejects the rod from the delivery tube. The delivery tube may have a longitudinal partition and a hub opening, where the hub opening provides external access to the hub and the longitudinal partition guides the hub longitudinally. The hub is optionally disposed within the delivery tube. An extension arm may be connected to the hub and may extend through the hub opening. If desired, the extension arm may be connected to the hub at a tapered connection point, where the tapered connection point enables removal of the extension arm from the hub after ejection of the rod from the delivery tube.
- In yet another embodiment, a method of fabricating an antimicrobial agent delivery system provides for coupling a hub to an antimicrobial agent-bearing rod. A longitudinal partition and a hub opening are formed in a delivery tube. The method further provides for disposing the rod within the delivery tube, where the hub opening provides external access to the catheter hub.
- The foregoing and further objects, features and advantages of the invention will become apparent from the following detailed description with reference to the accompanying drawings, wherein like numerals are used to represent like elements and wherein:
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FIG. 1A is a side view of an example a delivery tube according to one embodiment of the invention; -
FIG. 1B is a side view of an example of an antimicrobial agent delivery system before ejection according to one embodiment of the invention; -
FIG. 1C is a side view of an example of an antimicrobial agent delivery system during ejection according to one embodiment of the invention; -
FIG. 2 is a side view of an example of antimicrobial agent delivery system according to another embodiment of the invention; -
FIG. 3 is a side view of an example of an antimicrobial agent delivery system having a multiple lumen geometry according to another embodiment of the invention; -
FIG. 4 is a side view of an example of an antimicrobial agent delivery system having a plunger according to another embodiment of the invention; -
FIG. 5A is a side view of an example of a tapered connection point between a hub and an extension arm according to an embodiment of the invention; -
FIG. 5B is an end view of an alternative example of a tapered connection point between a hub and an extension arm according to another embodiment of the invention; -
FIG. 5C is a side view of a example of a non-tapered connection between a hub and an extension arm according to another embodiment of the invention; -
FIG. 6A is an end view of an example of a hub having surfaces defining one or more apertures that enable fluid transfer according to an embodiment of the invention; -
FIG. 6B is an end view of another example of a hub having surfaces defining one or more apertures that enable fluid transfer according to another embodiment of the invention; -
FIGS. 7A and 7B are cut-away views of an example of a valve according to an embodiment of the invention; and -
FIG. 8 is a flowchart of an example of a method of fabricating an antimicrobial agent delivery system according to one embodiment of the invention. - Some possible embodiments of the invention are hereafter described. One embodiment of the present invention is illustrated in
FIGS. 1A-1C . -
FIG. 1A shows adelivery tube 14. Thedelivery tube 14 has a longitudinal partition, in this case aperforation 20, and ahub opening 18. The longitudinal partition may be perforated, as shown, pre-scored, a continuous slit, or any other configuration that enables the functioning as described below. -
FIGS. 1B and 1C show an antimicrobialagent delivery system 10. The antimicrobialagent delivery system 10 includes an antimicrobial agent-bearing intervention device, such asrod 12, and thedelivery tube 14. The antimicrobial agent-bearing intervention device may have any suitable geometry. For example, it may be a tube or have an irregular shape, etc. Similarly, the delivery tube may have any suitable geometry. For example, it may have a cross-sectional geometry that is similar to or different from the cross-sectional geometry of the intervention device. - In the assembled configuration shown in
FIG. 1A , the antimicrobial agent-bearing intervention device is arod 12 is disposed within thedelivery tube 14. Thedelivery tube 14 facilitates manipulation of therod 12. That is, because therod 12 is in thedelivery tube 14, therod 12 can be moved by simply grasping thedelivery tube 14, without the need to handle therod 12 itself. - A
hub 16 is coupled to therod 12. In this illustrated embodiment, anextension arm 22 is coupled to thehub 16. In the assembled configuration shown inFIG. 1A , theextension arm 22 extends through thehub opening 18. - The operator can eject the
rod 12 from thetube 14 by longitudinally moving thehub 16 viaextension arm 22. Thehub opening 18 provides external access to thehub 16, and theperforation 20 guides thehub 16 longitudinally. Longitudinal movement of thehub 16 results in ejection of therod 12 from thedelivery tube 14. Thus, without touching therod 12, therod 12 can be removed from thedelivery tube 14 for use with a catheter. -
FIG. 5A shows an embodiment in which the extension arm 22 a is tapered toward the point where it connects with thehub 16 a, such that the extension arm 22 a and thehub 16 a have a taperedconnection point 24 a. InFIG. 5A , the width of the extension arm 22 a is tapered.FIG. 5B shows an alternative embodiment in which the thickness of the extension arm 22 b is tapered toward the point where it connects with the hub 16 b, such that the extension arm 22 b and the hub 16 b have a tapered connection point 24 b. The taperedconnection point 24 a or 24 b enables removal of the extension arm from the hub after ejection of the rod from the delivery tube 14 (FIGS. 1A-1C ). The tapered connection may have other suitable configurations, or other types of geometries or structures may be used, to facilitate separation of the extension arm from the hub, if desired. Of course, the extension arm need not be tapered, as shown inFIG. 5C , leaving a non-tapered connection point 24. - Turning now to
FIG. 2 , another embodiment of an antimicrobial agent delivery system is shown. In this embodiment, adelivery system 31 includes an antimicrobial agent-bearingrod 26 and a delivery tube 32. The antimicrobial agent-bearingrod 26 has aflex point 28. Ahub 30 is connected to the end of the antimicrobial agent-bearing rod and is disposed outside the delivery tube 32. It should be noted that disposing thehub 30 outside the delivery tube 32 enables the delivery tube 32 to be reduced in size considerably. It should also be noted that the illustrated delivery tube 32 has a longitudinal partition, where the partition is acontinuous slit 34 rather than a perforation. In such a case, it may be advantageous to structure the material of the delivery tube to enable theslit 34 to be self-sealing. One such material would be thermoplastic polyurethane (TPU), which has a low durometer characteristic to provide a desired level of “tackiness” on the surfaces that define theslit 34. The resulting slit 34 would provide a dynamic seal that can be broken and immediately re-sealed as therod 26 is advanced through thedelivery system 31. -
FIG. 3 shows another alternative embodiment of an antimicrobial agent delivery system in which adelivery tube 36 has a multiple lumen geometry. The multiple lumen geometry is defined by afirst tube 38 and asecond tube 40. An antimicrobial agent-bearingrod 42 is disposed within thefirst tube 38. Therod 42 may be connected to ahub 44 that is disposed within thesecond tube 40. Alternatively, therod 42 may be connected to a hub disposed within thefirst tube 38, and the hub may be connected to an extension arm that extends into thesecond tube 40. Therod 42 connects to the hub 44 (or the extension arm projects) through alongitudinal partition 46 defined by surfaces in a wall 48 that connects thefirst tube 38 to thesecond tube 40. The hub and rod can be advanced through thedelivery tube 36 by manipulating an extension arm (not shown) along a longitudinal partition formed in thesecond tube 44, by manipulating a plunger (not shown) intosecond tube 40 to act on the extension arm or hub, or by any other suitable actuation structure. - Turning now to
FIG. 4 , another embodiment of an antimicrobial agent delivery system is shown. In this embodiment, a delivery system 50 includes aplunger 52 extending out of an end of a delivery tube 54, where theplunger 52 is in contact with ahub 56. Thehub 56 is attached to an antimicrobial agent-bearingrod 58. The delivery tube 54 has openings at both ends to accommodate the longitudinal movement of theplunger 52 as well as therod 58. It should be noted that this delivery system 50 does not require a longitudinal partition. - Turning now to
FIG. 6A , an end view of a hub is shown. The illustrated hub has surfaces defining one ormore apertures 60 a that enable fluid transfer through the hub while the antimicrobial agent-bearing rod is installed in a catheter (not shown).FIG. 6B shows another possible configuration of apertures 60 b. With the apertures, the hub enables flushing and aspiration to take place around the rod. The apertures can be readily included in hub 16 (FIGS. 1A-1C ), hub 30 (FIG. 2 ), hub 44 (FIG. 3 ), and hub 56 (FIG. 4 ). - The outer surface of the above-described delivery tubes can include materials such as polyether block amide (PEBA), polyethylene, thermoplastic polyurethane (TPU), polyester elastomer, ionomer and thermoplastic vulcanizate to provide a relatively high surface texture. The result would be improved ergonomics and enhanced control. It should also be noted that the inner surface of the delivery tubes can include materials that are non-permeable to the particular antimicrobial agent being used. For example, in the case of iodine, the inner surface of the delivery tube may include PET.
-
FIGS. 7A and 7B show avalve 72 that can be incorporated into an anti-microbial agent delivery system such as any of the systems discussed above.Valve 72 is coupled to an open end of adelivery tube 74, where thedelivery tube 74 contains ahub 76 androd 78. Thevalve 72 attaches to thehub 76 and detaches from thedelivery tube 74 when ejection of therod 78 is complete. Thevalve 72 attached to thehub 76 as shown inFIG. 7B enables the flow of fluid to and from a catheter (not shown) to be restricted as desired. - Turning now to
FIG. 8 , themethod 62 of fabricating an antimicrobial agent delivery system is shown. Specifically, step 64 provides for coupling a hub to an antimicrobial agent-bearing rod.Step 66 provides for extruding a delivery tube.Step 68 provides for forming a longitudinal partition and a hub opening in the delivery tube.Step 70 provides for disposing the rod within the delivery tube, where the hub opening provides external access to the hub. It should be noted thatmethod 62 may further include the process of coupling an external arm to the hub, in which case the step of disposing the rod within the delivery tube would include having the extension arm extend through the hub opening. Alternatively, the rod may have a flex point, where the hub is disposed outside the delivery tube. It should also be noted that a wide variety of cutting systems, such as a laser cutting system or a mechanical cutting system, can be used to form the longitudinal partition and the hub opening atstep 68. Also, step 64 may come aftersteps - While the invention has been described with reference to what are presently considered to be preferred embodiments thereof, it is to be understood that the invention is not limited to the disclosed embodiments or constructions. On the contrary, the protection sought for the invention as defined in the appended claims is intended to cover various modifications and equivalent arrangements. In addition, while the various elements of the disclosed invention are described and/or shown in various combinations and configurations, which are exemplary, other combinations and configurations, including more, less or only a single embodiment, are also within the spirit and scope of the present invention.
Claims (20)
1. An antimicrobial agent delivery system comprising:
an antimicrobial agent-bearing intervention device;
a hub coupled to the intervention device; and
a delivery tube for containing the intervention device, wherein the delivery tube facilitates handling of the intervention device;
wherein longitudinal movement of the hub ejects the intervention device from the delivery tube.
2. The delivery system of claim 1 , wherein the intervention device is a rod.
3. The delivery system of claim 1 , wherein the delivery tube has a longitudinal partition and a hub opening, wherein the hub opening provides external access to the hub, and wherein the longitudinal partition guides the hub longitudinally.
4. The delivery system of claim 3 , wherein the hub is disposed within the delivery tube, and wherein the delivery system further including an extension arm coupled to the hub and extending through the hub opening.
5. The delivery system of claim 4 , wherein the extension arm and the hub have a tapered connection point, and wherein the tapered connection point enables removal of the extension arm from the hub after ejection of the intervention device from the delivery tube.
6. The delivery system of claim 3 , wherein the intervention device has a flex point and the hub is disposed outside the delivery tube.
7. The delivery system of claim 3 , wherein the longitudinal partition is a perforation.
8. The delivery system of claim 3 , wherein the longitudinal partition is a continuous slit.
9. The delivery system of claim 8 , wherein the continuous slit is self-sealing.
10. The delivery system of claim 9 , wherein the delivery tube comprises a low durometer thermoplastic polyurethane or polyethylene.
11. The delivery system of claim 1 , wherein the delivery tube has a multiple lumen geometry defined by a first tube and a second tube, the intervention device being disposed within the first tube.
12. The delivery system of claim 1 , wherein the hub has one or more apertures that enable fluid transfer through the hub when the intervention device is installed in a catheter.
13. The delivery system of claim 1 , further including a plunger for pushing on the hub to eject the intervention device from the delivery tube.
14. The delivery system of claim 1 , wherein an outer surface of the delivery tube includes at least one of a polyether block amide (PEBA), thermoplastic polyurethane (TPU), polyester elastomer, ionomer and thermoplastic vulcanizate to provide a relatively high surface texture.
15. The delivery system of claim 1 , wherein the antimicrobial agent includes iodine, and wherein the delivery tube has an inner surface that is non-permeable to iodine.
16. The delivery system of claim 15 , wherein the inner surface of the delivery tube is polyester or a similar material non-permeable to the particular antimicrobial agent.
17. The delivery system of claim 1 , further including a valve coupled to an open end of the delivery tube.
18. A method of fabricating an antimicrobial agent delivery system comprising:
coupling a hub to an antimicrobial agent-bearing intervention device;
forming a longitudinal partition and a hub opening in a delivery tube; and
disposing the intervention device within the delivery tube, the hub opening providing external access to the hub.
19. The method of claim 18 , further including:
coupling an external arm to the hub; and
disposing the hub within the delivery tube, the extension arm extending through the hub opening.
20. The method of claim 18 , wherein the intervention device has a flex point, the method further including disposing the hub outside the delivery tube.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/786,021 US20050192590A1 (en) | 2004-02-26 | 2004-02-26 | Antimicrobial agent delivery system |
CA002556051A CA2556051A1 (en) | 2004-02-26 | 2005-01-27 | Antimicrobial agent delivery system |
PCT/US2005/003016 WO2005092421A1 (en) | 2004-02-26 | 2005-01-27 | Antimicrobial agent delivery system |
EP05712451A EP1718358A1 (en) | 2004-02-26 | 2005-01-27 | Antimicrobial agent delivery system |
US12/767,620 US8123728B2 (en) | 2004-02-26 | 2010-04-26 | Antimicrobial agent delivery system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/786,021 US20050192590A1 (en) | 2004-02-26 | 2004-02-26 | Antimicrobial agent delivery system |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/767,620 Division US8123728B2 (en) | 2004-02-26 | 2010-04-26 | Antimicrobial agent delivery system |
Publications (1)
Publication Number | Publication Date |
---|---|
US20050192590A1 true US20050192590A1 (en) | 2005-09-01 |
Family
ID=34886662
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/786,021 Abandoned US20050192590A1 (en) | 2004-02-26 | 2004-02-26 | Antimicrobial agent delivery system |
US12/767,620 Expired - Lifetime US8123728B2 (en) | 2004-02-26 | 2010-04-26 | Antimicrobial agent delivery system |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/767,620 Expired - Lifetime US8123728B2 (en) | 2004-02-26 | 2010-04-26 | Antimicrobial agent delivery system |
Country Status (4)
Country | Link |
---|---|
US (2) | US20050192590A1 (en) |
EP (1) | EP1718358A1 (en) |
CA (1) | CA2556051A1 (en) |
WO (1) | WO2005092421A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070239107A1 (en) * | 2003-12-15 | 2007-10-11 | Jon Lundberg | Device and Method for Administering Therapeutic Agents |
US20090143470A1 (en) * | 2003-03-24 | 2009-06-04 | Becton, Dickinson And Company | Invisible Antimicrobial Glove and Hand Antiseptic |
US7815599B2 (en) * | 2004-12-10 | 2010-10-19 | Boston Scientific Scimed, Inc. | Catheter having an ultra soft tip and methods for making the same |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050090785A1 (en) * | 2003-10-22 | 2005-04-28 | Tan Sharon M.L. | Catheter with a sidearm for delivery of antimicrobial agents to prevent infection |
US8936583B2 (en) | 2007-09-28 | 2015-01-20 | Hollister Incorporated | Multi-layer catheter tubes with odor barrier |
ES2739030T3 (en) * | 2007-09-28 | 2020-01-28 | Hollister Inc | Multi-layer anti-odor barrier tube, and combination of anti-odor barrier tube and anti-odor barrier collection bag |
US11045589B2 (en) | 2017-09-22 | 2021-06-29 | Becton, Dickinson And Company | 4% trisodium citrate solution for use as a catheter lock solution |
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- 2005-01-27 EP EP05712451A patent/EP1718358A1/en not_active Withdrawn
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Also Published As
Publication number | Publication date |
---|---|
US20100274201A1 (en) | 2010-10-28 |
EP1718358A1 (en) | 2006-11-08 |
US8123728B2 (en) | 2012-02-28 |
CA2556051A1 (en) | 2005-10-06 |
WO2005092421A1 (en) | 2005-10-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: SCIMED LIFE SYSTEMS, INC., MINNESOTA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FEELEY, KRISTIN;LAREAU, RAY;REEL/FRAME:015026/0389;SIGNING DATES FROM 20040212 TO 20040217 |
|
AS | Assignment |
Owner name: BOSTON SCIENTIFIC SCIMED, INC.,MINNESOTA Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:024288/0549 Effective date: 20041215 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- AFTER EXAMINER'S ANSWER OR BOARD OF APPEALS DECISION |