US20050267567A1 - Device and method for treating ischemic heart disease - Google Patents

Device and method for treating ischemic heart disease Download PDF

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Publication number
US20050267567A1
US20050267567A1 US11/186,745 US18674505A US2005267567A1 US 20050267567 A1 US20050267567 A1 US 20050267567A1 US 18674505 A US18674505 A US 18674505A US 2005267567 A1 US2005267567 A1 US 2005267567A1
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Prior art keywords
narrowing
stent
lumen
tissue
coronary sinus
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Abandoned
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US11/186,745
Inventor
Ilan Shalev
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Neovasc Medical Ltd
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Neovasc Medical Ltd
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Priority to US11/186,745 priority Critical patent/US20050267567A1/en
Publication of US20050267567A1 publication Critical patent/US20050267567A1/en
Priority to US12/632,762 priority patent/US20100179643A1/en
Assigned to HALPERIN, HAIM reassignment HALPERIN, HAIM ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SHALEV, ILAN
Assigned to NEOVASC MEDICAL LTD. reassignment NEOVASC MEDICAL LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NEOVASC INC.
Assigned to NEOVASC INC. reassignment NEOVASC INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HALPERIN, HAIM
Abandoned legal-status Critical Current

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    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter

Definitions

  • the present invention relates to a device and method for treating ischemic heart disease and, more particularly, to a coronary sinus stent and to surgical methods for implanting same.
  • the present invention involves implantation of the stent in the coronary sinus as a means of treating patients suffering from, for example, diffuse coronary artery disease, especially in cases where conventional balloon catheterization, bypass surgery and drugs are infeasible or ineffective treatment methods.
  • the carbon dioxide carrying blood leaves the heart muscle via a system of coronary veins which begin as small vessels and progressively merge into larger vessels. As in other organs, the veins are approximately parallel to the arteries, although the blood flow therein is in the opposite direction.
  • the coronary veins terminate in a reservoir referred to as the coronary sinus, which, in turn, drains into the right atrium where it mixes with venous blood from peripheral organs. Venous blood is pumped from the right atrium into the pulmonary arteries which perfuse the lung and facilitate an exchange of gases, with carbon dioxide being replaced with oxygen.
  • cardiac ischemia In cases where the supply of blood flowing to the heart muscle via the coronary arteries is insufficient, oxygenation of the muscle tissue of the heart is reduced, producing a condition known as cardiac ischemia. Ischemia can result in atrophy and or necrosis of tissue. In the case of cardiac ischemia, this atrophy or necrosis reduces heart function and adversely affects the blood supply to the remainder of the body. Patients suffering from cardiac ischemia typically suffer from chest pains and difficulty in breathing. Cardiac ischemia may precipitate a heart attack in some cases.
  • Cardiac ischemia is most often caused by atherosclerosis or other conditions which block one or more coronary arteries.
  • Current treatment options include balloon catheterization, bypass surgery and treatment with drugs. Balloon catheterization and bypass surgery are only feasible options if the coronary artery blockage exists in a small number of discrete locations, usually in fairly large blood vessels.
  • Balloon catheterization involves insertion of a catheter with an inflatable tip via a peripheral blood vessel into the affected coronary artery.
  • the procedure is performed with the aid of a visualization (imaging) device (e.g., ultrasound, X-ray, fluoroscopy) which shows the catheter tip and the coronary artery occlusion.
  • imaging e.g., ultrasound, X-ray, fluoroscopy
  • the tip When the tip is in proximity to the occlusion, it is inflated, thereby widening the artery and releasing the occlusion.
  • the balloon catheter serves for placing a stent within the artery and to extend or erect the stent to its service dimensions in a process known as stent catheterization.
  • Bypass surgery is an invasive procedure which involves opening the thoracic cavity and implanting a tube so as to replace or bypass an occluded portion of the coronary artery.
  • the tube may be either artificial, or a peripheral blood vessel derived from the patient. While this method has proven efficacy, it has all of the disadvantages inherent in invasive surgery, e.g., post-surgical infection, complications with anesthesia, relatively long recovery time and high cost.
  • drugs include, for example, nitrates, ⁇ -blockers and calcium channel blockers.
  • drugs treated with drugs often continue to have difficulty performing daily activities, suffer from shortness of breath and chest pains.
  • This procedure is an open chest (thoracic) procedure, and therefore suffers all the limitations associated with such procedures, including, but not limited to, post-surgical infection, complications with anesthesia, relatively long recovery time and high cost.
  • the prior art fails to teach minimal invasive means of reducing the flow of blood exiting the coronary sinus without thoracic surgery.
  • a narrowing intraluminal stent for placement in a body lumen having a cross sectional dimension
  • the narrowing intraluminal stent comprising a hollow body having a first end, a second end, and a flow passage being defined therethrough from the first end to the second end, the hollow body being designed for intraluminal placement in the body lumen and having at least one portion of an inner cross sectional dimension smaller than the cross sectional dimension of the body lumen, so as to artificially narrow a passage through the body lumen.
  • a method of artificially narrowing a passage through a body lumen having a cross sectional dimension comprising the step of implanting a narrowing intraluminal stent in the body lumen, thereby artificially narrowing the passage through a body lumen.
  • a method of initiating or accelerating angiogenesis in order to treat or prevent ischemia comprising the step of artificially narrowing a passage through a blood vessel having a cross sectional dimension by implanting a narrowing intraluminal stent therein, thereby reducing a flow of blood therethrough, creating back pressure and initiating or accelerating angiogenesis upstream thereto.
  • the stent is constructed of a biologically inert material.
  • the stent is coated with a biologically inert material.
  • the biologically inert material is selected from the group consisting of stainless steel, nitinol and biocompatible plastic material.
  • the hollow body further includes at least one expandable portion for affixing the narrowing intraluminal stent in the body lumen.
  • the lumen is a coronary sinus and the stent is configured for placement therein so as to decrease a flow of blood therethrough.
  • the decrease in flow of blood through the coronary sinus is sufficient so as to cause coronary angiogenesis.
  • the inner cross sectional dimension of the hollow body is greater than 7 mm 2 and less than 28 mm 2 .
  • the length of the hollow body, from the first end to the second end is greater than 20 mm and less than 50 mm.
  • an aspect ratio defined by an inner cross sectional diameter of the hollow body divided by a length of the hollow body from the first end to the second end is greater than 0.1 and less than 0.2.
  • a ratio defined by a narrowest inner cross sectional diameter of the hollow body divided by a length of the hollow body from the first end to the second end is greater than 0.1 and less than 0.2.
  • the at least one expandable portion expands as a result of an occurrence selected from the group consisting of (i) application of a force which expands the at least one expandable portion; and (ii) removal of a force which contracts the at least one expandable portion.
  • the force which expands the at least one expandable portion is suppliable by an inflatable balloon of a catheter receivable within the hollow body of the stent.
  • the affixing of the narrowing intraluminal stent in the body lumen occurs as a result of a cause selected from the group consisting of (i) a physical contact between a portion of the narrowing intraluminal stent and an inner surface of the body lumen; and (ii) a biological process occurring in cells of an inner surface of the body lumen as a result of a presence therein of the narrowing intraluminal stent.
  • the hollow body further includes at least two expandable portions for affixing the narrowing intraluminal stent in the body lumen.
  • an integrity of the at least one expandable portion is preserved during a transition from elasticity to plasticity.
  • the at least one expandable portion comprises a collapsible grid.
  • the step of implanting the narrowing intraluminal stent in the body lumen is effected with a catheter.
  • guiding the catheter to the lumen is effected under imaging.
  • the step of implanting the narrowing intraluminal stent in the body lumen and the step of expanding the at least one expandable portion are effected with a balloon catheter.
  • guiding the balloon catheter to the lumen is effected under imaging.
  • the imaging is accomplished by a method selected from the group consisting of computer assisted tomography (CT), magnetic resonance imaging (MRI), proton emission tomography (PET), ultrasonography, three dimensional ultrasonography, fluoroscopy, electrophysiological imaging, X-ray imagery and echocardiography.
  • CT computer assisted tomography
  • MRI magnetic resonance imaging
  • PET proton emission tomography
  • ultrasonography three dimensional ultrasonography
  • fluoroscopy electrophysiological imaging
  • electrophysiological imaging X-ray imagery and echocardiography
  • the present invention successfully addresses the shortcomings of the presently known configurations by providing a device and method for treating or preventing cardiac ischemia caused by, for example, diffuse coronary artery disease which does not require thoracic surgery.
  • FIG. 1 is a perspective view of one embodiment of a core construction of the stent of the present invention shown in a non-expanded position;
  • FIG. 2 is a perspective view of the same embodiment of the core construction of the stent of the present invention in an expanded position;
  • FIGS. 3 a - b show the particulars of a construction of a collapsible grid for use in constructing the stent depicted in FIGS. 1 and 2 ;
  • FIG. 4 is a schematic diagram illustrating placement of a stent, the core construction thereof is depicted in FIGS. 1 and 2 , in a body lumen by means of a balloon catheter;
  • FIGS. 5 a - b schematically illustrate an alternate method for placing a stent of the present invention within a body lumen
  • FIG. 6 is a cross sectional view of a stent according to the present invention situated within a body lumen.
  • the present invention is of a device and method which can be used in treating or preventing ischemic heart disease and, more particularly, to a coronary sinus narrowing stent and to surgical methods for implanting same.
  • the present invention involves implantation of the stent in the coronary sinus as a means of treating patients suffering from, for example, diffuse coronary artery disease, especially in cases where conventional balloon catheterization, bypass surgery and drugs are infeasible or ineffective treatment methods.
  • FIGS. 1-6 illustrate a narrowing intraluminal stent for placement in a body lumen 28 , which stent is referred to hereinbelow as stent 20 .
  • Stent 20 includes a hollow body 22 .
  • Body 22 has a first end 24 , a second end 26 , and a flow passage 30 (see FIG. 6 ) defined therethrough, from first end 24 to second end 26 .
  • Hollow body 22 is designed for intraluminal placement in the body lumen 28 and has at least one portion 32 of an inner cross sectional dimension smaller than a cross sectional dimension 34 of body lumen 28 , so as to artificially narrow a passage through body lumen 28 .
  • the present invention is also provides a method of artificially narrowing a passage through body lumen 28 having a cross sectional dimension 34 .
  • the method includes the step of implanting stent 20 in body lumen 28 , thereby artificially narrowing the passage through body lumen 28 .
  • Such placement when in a blood vessel, is used to initiate or accelerate angiogenesis in order, for example, to treat or prevent ischemia by reducing a flow of blood through the blood vessel, creating back pressure and initiating or accelerating angiogenesis upstream thereto.
  • stent 20 is preferably constructed of, or it is coated with, a biologically inert material.
  • Biologically inert materials suited for use in constructing or coating stent 20 include, but are not necessarily limited to, stainless steel, nitinol and biocompatible plastic material.
  • hollow body 22 may further include at least one expandable portion 36 (two are pictured) so as to fix stent 20 in lumen 28 .
  • hollow body 22 In order to more firmly affix stent 20 within lumen 28 , it is often desirable for hollow body 22 to further include at least two expandable portions 36 as pictured in FIGS. 1, 2 , 4 , 5 and 6 .
  • Stent 20 is often configured so that integrity of expandable portion 36 is preserved during a transition from elasticity to plasticity.
  • expandable portion 36 takes the form of a collapsible grid 42 containing a plurality of holes 48 . Grid 42 is generally fully contained within a coating 46 (see, FIGS.
  • FIGS. 3 a - b show an example of details of the construction of a collapsible grid for use as part of stent 20 .
  • Stent 20 is depicted in FIG. 2 in an expanded position with expandable portions 36 , expanded so that flow passage 30 (indicated by bent arrow) is clearly visible (see also FIG. 6 ; hollow arrow).
  • lumen 28 is often a coronary sinus and stent 20 is configured for placement therein, so as to decrease a flow of blood therethrough. Decreasing the flow of blood through the coronary sinus, if the decrease is of sufficient magnitude, can cause coronary angiogenesis, thereby eventually reliving cardiac ischemia.
  • stent 20 is often constructed with an inner cross sectional dimension 32 of hollow body 22 greater than 7 mm 2 and less than 28 mm 2 .
  • stent 20 is often constructed with a length of hollow body 22 , from first end 24 to second end 26 , greater than 20 mm and less than 50 mm.
  • These dimensions produce an aspect ratio defined by an inner cross sectional diameter of the hollow body divided by a length of hollow body 22 from first end 24 to second end 26 which is greater than 0.1 and less than 0.2.
  • a ratio defined by a widest inner cross sectional diameter of said hollow is body divided by a narrowest inner cross sectional diameter of said hollow body is greater than 2.6 and less than 4.3.
  • expansion of expandable portions 36 may be achieved, for example, by application of a force which expands expandable portions 36 or by removal of a force which contracts expandable portions 36 as is further explained hereinbelow.
  • the force which expands the expandable portion 36 is suppliable by, for example, an inflatable balloon 40 of a catheter 38 receivable within hollow body 22 of stent 20 ( FIG. 4 ).
  • Catheter 38 may used to implant stent 20 into the body of a patient, for example via the femoral vein, through the superior vena cava and the right atrium to the coronary sinus.
  • Guidance of catheter 38 may be effected under imaging. Imaging may be accomplished, for example, by computer assisted tomography (CT), magnetic resonance imaging (MRI), proton emission tomography (PET), ultrasonography, three dimensional ultrasonography, fluoroscopy, electrophysiological imaging, X-ray imagery or echocardiogaphy.
  • Stent 20 may be fixed in place, for example, as a result of a physical contact 44 between a portion of stent 20 and an inner surface of lumen 28 .
  • stent 20 may be fixed in place, as a result of a biological process occurring in cells of an inner surface of lumen 28 as a result of a presence therein of stent 20 .
  • Biological processes which would tend to fix stent 20 in place include, but are not limited to, secretion of a fluid, cell death, tissue growth, scarring, clotting, swelling and localized inflammation.
  • balloon 40 is deflated and withdrawn along with catheter 38 . The end result of this process is that the effective cross sectional dimension of lumen 28 is reduced from its original size 34 to the size of inner cross sectional dimension 32 of hollow body 22 of stent 20 .
  • FIGS. 5 a - b An alternate method of affixing stent 20 in lumen 28 is illustrated in FIGS. 5 a - b .
  • This method relies upon removal of a force which contracts expandable portion 36 .
  • this method employs a catheter 38 equipped with a piston 50 .
  • stent 20 is inserted in catheter 38 in a collapsed position.
  • stent 20 has at least one expandable portion 36 (two are pictured) having an inherent spring-like memory. Insertion and guidance are as described hereinabove for the balloon catheterization method.
  • a flow passage 30 through lumen 28 is now limited by cross sectional dimension 32 of stent 20 and not by cross sectional dimension 34 of lumen 28 . This limitation occurs as a result of contact 44 between stent 20 and lumen 28 . Flow through holes 48 of expandable portion 36 is prevented by coating 46 on stent 20 .

Abstract

A narrowing intraluminal stent is disclosed and comprises a hollow body and a flow passage therethrough, the hollow body designed for intraluminal placement and having at least one portion of an inner cross sectional dimension smaller than the cross sectional dimension of the lumen, so as to artificially narrow a passage through the body lumen. A method of artificially narrowing a passage through a body lumen using the stent is also disclosed.

Description

    RELATED APPLICATIONS
  • This application is a Divisional application of U.S. application Ser. No. 09/534,968, filed on Mar. 27, 2000, the disclosure of which is incorporated herein by reference.
  • FIELD AND BACKGROUND OF THE INVENTION
  • The present invention relates to a device and method for treating ischemic heart disease and, more particularly, to a coronary sinus stent and to surgical methods for implanting same. Specifically, the present invention involves implantation of the stent in the coronary sinus as a means of treating patients suffering from, for example, diffuse coronary artery disease, especially in cases where conventional balloon catheterization, bypass surgery and drugs are infeasible or ineffective treatment methods.
  • Blood arrives at the heart muscle via coronary arteries which begin as vessels with a diameter of several millimeters and branch progressively to smaller and smaller vessels in order to supply all the cells of the heart muscle. Blood arriving at the heart carries oxygen and nutrients which are exchanged for carbon dioxide and other wastes produced by cellular respiration. The carbon dioxide carrying blood leaves the heart muscle via a system of coronary veins which begin as small vessels and progressively merge into larger vessels. As in other organs, the veins are approximately parallel to the arteries, although the blood flow therein is in the opposite direction. The coronary veins terminate in a reservoir referred to as the coronary sinus, which, in turn, drains into the right atrium where it mixes with venous blood from peripheral organs. Venous blood is pumped from the right atrium into the pulmonary arteries which perfuse the lung and facilitate an exchange of gases, with carbon dioxide being replaced with oxygen.
  • In cases where the supply of blood flowing to the heart muscle via the coronary arteries is insufficient, oxygenation of the muscle tissue of the heart is reduced, producing a condition known as cardiac ischemia. Ischemia can result in atrophy and or necrosis of tissue. In the case of cardiac ischemia, this atrophy or necrosis reduces heart function and adversely affects the blood supply to the remainder of the body. Patients suffering from cardiac ischemia typically suffer from chest pains and difficulty in breathing. Cardiac ischemia may precipitate a heart attack in some cases.
  • Cardiac ischemia is most often caused by atherosclerosis or other conditions which block one or more coronary arteries. Current treatment options include balloon catheterization, bypass surgery and treatment with drugs. Balloon catheterization and bypass surgery are only feasible options if the coronary artery blockage exists in a small number of discrete locations, usually in fairly large blood vessels.
  • Balloon catheterization involves insertion of a catheter with an inflatable tip via a peripheral blood vessel into the affected coronary artery. The procedure is performed with the aid of a visualization (imaging) device (e.g., ultrasound, X-ray, fluoroscopy) which shows the catheter tip and the coronary artery occlusion. When the tip is in proximity to the occlusion, it is inflated, thereby widening the artery and releasing the occlusion. In cases, the balloon catheter serves for placing a stent within the artery and to extend or erect the stent to its service dimensions in a process known as stent catheterization. These procedures are often preferred by patients and doctors because it is relatively non-invasive.
  • Bypass surgery is an invasive procedure which involves opening the thoracic cavity and implanting a tube so as to replace or bypass an occluded portion of the coronary artery. The tube may be either artificial, or a peripheral blood vessel derived from the patient. While this method has proven efficacy, it has all of the disadvantages inherent in invasive surgery, e.g., post-surgical infection, complications with anesthesia, relatively long recovery time and high cost.
  • Patients with cardiac ischemia caused by blockage of many small vessels are not candidates for balloon catheterization or bypass surgery and are currently treatable only with drugs. These drugs include, for example, nitrates, β-blockers and calcium channel blockers. Unfortunately, patients treated with drugs often continue to have difficulty performing daily activities, suffer from shortness of breath and chest pains.
  • It has long been known that reducing the flow of blood exiting the coronary sinus can have beneficial effects on cardiac ischemia (Gross L. Blum L., Silverman G. J Exper. Med. (1937) 85:91, 1937; Robertson H. H. (1935) Am Heart. J. 10:533; Beck C. S., Leighninger D. S. (1954) Am. Heart J. 156:1226; Beck C. S., Leighninger D. S. (1955) Am. Heart J. 159:1264; Beck C. S., Leighninger D. S. (1961) Med. Tms. (NY) 89:17; Beck C. S., Leighninger D. S., Brofman B. L., Bond J. F. (1958) J. Amer. Med. Ass. 168:2110; Sandler G., Slesser B. V., Lawson C. W. (1967) Thorax 22:34). It is believed that reducing the flow of blood exiting the coronary sinus increases the blood pressure in the coronary arteries, thereby inducing the formation of new blood vessels, a process known as angiogenesis. The prior art procedure of reducing the flow of blood exiting the coronary sinus involves placement of a narrowing ring external to the coronary sinus, so as to narrow its inner diameter and thereby restrict blood flow therethrough. This procedure, however, is an open chest (thoracic) procedure, and therefore suffers all the limitations associated with such procedures, including, but not limited to, post-surgical infection, complications with anesthesia, relatively long recovery time and high cost. However, the prior art fails to teach minimal invasive means of reducing the flow of blood exiting the coronary sinus without thoracic surgery.
  • There is thus a widely recognized need for, and it would be highly advantageous to have, a device and method for reducing the flow of blood exiting the coronary sinus without thoracic surgery as a means of treating or preventing cardiac ischemia caused by, for example, diffuse coronary artery disease.
  • SUMMARY OF THE INVENTION
  • According to one aspect of the present invention there is provided a narrowing intraluminal stent for placement in a body lumen having a cross sectional dimension, the narrowing intraluminal stent comprising a hollow body having a first end, a second end, and a flow passage being defined therethrough from the first end to the second end, the hollow body being designed for intraluminal placement in the body lumen and having at least one portion of an inner cross sectional dimension smaller than the cross sectional dimension of the body lumen, so as to artificially narrow a passage through the body lumen.
  • According to another aspect of the present invention there is provided a method of artificially narrowing a passage through a body lumen having a cross sectional dimension, the method comprising the step of implanting a narrowing intraluminal stent in the body lumen, thereby artificially narrowing the passage through a body lumen.
  • According to yet another aspect of the present invention there is provided a method of initiating or accelerating angiogenesis in order to treat or prevent ischemia, the method comprising the step of artificially narrowing a passage through a blood vessel having a cross sectional dimension by implanting a narrowing intraluminal stent therein, thereby reducing a flow of blood therethrough, creating back pressure and initiating or accelerating angiogenesis upstream thereto.
  • According to further features in preferred embodiments of the invention described below, the stent is constructed of a biologically inert material.
  • According to still further features in the described preferred embodiments, the stent is coated with a biologically inert material.
  • According to further features in preferred embodiments of the invention described below, the biologically inert material is selected from the group consisting of stainless steel, nitinol and biocompatible plastic material.
  • According to still further features in the described preferred embodiments, the hollow body further includes at least one expandable portion for affixing the narrowing intraluminal stent in the body lumen.
  • According to still further features in the described preferred embodiments, the lumen is a coronary sinus and the stent is configured for placement therein so as to decrease a flow of blood therethrough.
  • According to still further features in the described preferred embodiments, the decrease in flow of blood through the coronary sinus is sufficient so as to cause coronary angiogenesis.
  • According to still further features in the described preferred embodiments, the inner cross sectional dimension of the hollow body is greater than 7 mm2 and less than 28 mm2.
  • According to still further features in the described preferred embodiments, the length of the hollow body, from the first end to the second end, is greater than 20 mm and less than 50 mm.
  • According to still further features in the described preferred embodiments, an aspect ratio defined by an inner cross sectional diameter of the hollow body divided by a length of the hollow body from the first end to the second end is greater than 0.1 and less than 0.2.
  • According to still further features in the described preferred embodiments, a ratio defined by a narrowest inner cross sectional diameter of the hollow body divided by a length of the hollow body from the first end to the second end is greater than 0.1 and less than 0.2.
  • According to still further features in the described preferred embodiments, the at least one expandable portion expands as a result of an occurrence selected from the group consisting of (i) application of a force which expands the at least one expandable portion; and (ii) removal of a force which contracts the at least one expandable portion.
  • According to still further features in the described preferred embodiments, the force which expands the at least one expandable portion is suppliable by an inflatable balloon of a catheter receivable within the hollow body of the stent.
  • According to still further features in the described preferred embodiments, the affixing of the narrowing intraluminal stent in the body lumen occurs as a result of a cause selected from the group consisting of (i) a physical contact between a portion of the narrowing intraluminal stent and an inner surface of the body lumen; and (ii) a biological process occurring in cells of an inner surface of the body lumen as a result of a presence therein of the narrowing intraluminal stent.
  • According to still further features in the described preferred embodiments, the hollow body further includes at least two expandable portions for affixing the narrowing intraluminal stent in the body lumen.
  • According to still further features in the described preferred embodiments, an integrity of the at least one expandable portion is preserved during a transition from elasticity to plasticity.
  • According to still further features in the described preferred embodiments, the at least one expandable portion comprises a collapsible grid.
  • According to still further features in the described preferred embodiments, the step of implanting the narrowing intraluminal stent in the body lumen is effected with a catheter.
  • According to still further features in the described preferred embodiments, guiding the catheter to the lumen is effected under imaging.
  • According to still further features in the described preferred embodiments, the step of implanting the narrowing intraluminal stent in the body lumen and the step of expanding the at least one expandable portion are effected with a balloon catheter.
  • According to still further features in the described preferred embodiments, guiding the balloon catheter to the lumen is effected under imaging.
  • According to still further features in the described preferred embodiments, the imaging is accomplished by a method selected from the group consisting of computer assisted tomography (CT), magnetic resonance imaging (MRI), proton emission tomography (PET), ultrasonography, three dimensional ultrasonography, fluoroscopy, electrophysiological imaging, X-ray imagery and echocardiography.
  • The present invention successfully addresses the shortcomings of the presently known configurations by providing a device and method for treating or preventing cardiac ischemia caused by, for example, diffuse coronary artery disease which does not require thoracic surgery.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The invention is herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of the preferred embodiments of the present invention only, and are presented in the cause of providing what is believed to be the most useful and readily understood description of the principles and conceptual aspects of the invention. In this regard, no attempt is made to show structural details of the invention in more detail than is necessary for a fundamental understanding of the invention, the description taken with the drawings making apparent to those skilled in the art how the several forms of the invention may be embodied in practice.
  • In the drawings:
  • FIG. 1 is a perspective view of one embodiment of a core construction of the stent of the present invention shown in a non-expanded position;
  • FIG. 2 is a perspective view of the same embodiment of the core construction of the stent of the present invention in an expanded position;
  • FIGS. 3 a-b show the particulars of a construction of a collapsible grid for use in constructing the stent depicted in FIGS. 1 and 2;
  • FIG. 4 is a schematic diagram illustrating placement of a stent, the core construction thereof is depicted in FIGS. 1 and 2, in a body lumen by means of a balloon catheter;
  • FIGS. 5 a-b schematically illustrate an alternate method for placing a stent of the present invention within a body lumen; and
  • FIG. 6 is a cross sectional view of a stent according to the present invention situated within a body lumen.
  • DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The present invention is of a device and method which can be used in treating or preventing ischemic heart disease and, more particularly, to a coronary sinus narrowing stent and to surgical methods for implanting same. Specifically, the present invention involves implantation of the stent in the coronary sinus as a means of treating patients suffering from, for example, diffuse coronary artery disease, especially in cases where conventional balloon catheterization, bypass surgery and drugs are infeasible or ineffective treatment methods.
  • The principles and operation of a device and methods which can be used for treating or preventing ischemic heart disease according to the present invention may be better understood with reference to the drawings and accompanying descriptions.
  • Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of the components set forth in the following description or illustrated in the drawings. The invention is capable of other embodiments or of being practiced or carried out in various ways. Also, it is to be understood that the phraseology and terminology employed herein is for the purpose of description and should not be regarded as limiting.
  • Referring now to the drawings, FIGS. 1-6 illustrate a narrowing intraluminal stent for placement in a body lumen 28, which stent is referred to hereinbelow as stent 20. Stent 20 includes a hollow body 22. Body 22 has a first end 24, a second end 26, and a flow passage 30 (see FIG. 6) defined therethrough, from first end 24 to second end 26. Hollow body 22 is designed for intraluminal placement in the body lumen 28 and has at least one portion 32 of an inner cross sectional dimension smaller than a cross sectional dimension 34 of body lumen 28, so as to artificially narrow a passage through body lumen 28.
  • Accordingly, the present invention is also provides a method of artificially narrowing a passage through body lumen 28 having a cross sectional dimension 34. The method includes the step of implanting stent 20 in body lumen 28, thereby artificially narrowing the passage through body lumen 28. Such placement, when in a blood vessel, is used to initiate or accelerate angiogenesis in order, for example, to treat or prevent ischemia by reducing a flow of blood through the blood vessel, creating back pressure and initiating or accelerating angiogenesis upstream thereto.
  • In order to facilitate safe use of stent 20, and to allow practice of is the methods described hereinabove, stent 20 is preferably constructed of, or it is coated with, a biologically inert material. Biologically inert materials suited for use in constructing or coating stent 20 include, but are not necessarily limited to, stainless steel, nitinol and biocompatible plastic material.
  • Because the function of stent 20 requires that it be affixed within lumen 28, hollow body 22 may further include at least one expandable portion 36 (two are pictured) so as to fix stent 20 in lumen 28. In order to more firmly affix stent 20 within lumen 28, it is often desirable for hollow body 22 to further include at least two expandable portions 36 as pictured in FIGS. 1, 2, 4, 5 and 6. Stent 20 is often configured so that integrity of expandable portion 36 is preserved during a transition from elasticity to plasticity. Frequently, expandable portion 36 takes the form of a collapsible grid 42 containing a plurality of holes 48. Grid 42 is generally fully contained within a coating 46 (see, FIGS. 4 and 6), for example, a biologically inert coating as described hereinabove. FIGS. 3 a-b show an example of details of the construction of a collapsible grid for use as part of stent 20. Stent 20 is depicted in FIG. 2 in an expanded position with expandable portions 36, expanded so that flow passage 30 (indicated by bent arrow) is clearly visible (see also FIG. 6; hollow arrow).
  • Because the invention was originally conceived to address the problem of ischemic heart disease, lumen 28 is often a coronary sinus and stent 20 is configured for placement therein, so as to decrease a flow of blood therethrough. Decreasing the flow of blood through the coronary sinus, if the decrease is of sufficient magnitude, can cause coronary angiogenesis, thereby eventually reliving cardiac ischemia.
  • In order to suit stent 20 for use in a coronary sinus as described hereinabove, stent 20 is often constructed with an inner cross sectional dimension 32 of hollow body 22 greater than 7 mm2 and less than 28 mm2. For the same reason, stent 20 is often constructed with a length of hollow body 22, from first end 24 to second end 26, greater than 20 mm and less than 50 mm. These dimensions produce an aspect ratio defined by an inner cross sectional diameter of the hollow body divided by a length of hollow body 22 from first end 24 to second end 26 which is greater than 0.1 and less than 0.2.
  • According to a preferred embodiment of the present invention a ratio defined by a widest inner cross sectional diameter of said hollow is body divided by a narrowest inner cross sectional diameter of said hollow body is greater than 2.6 and less than 4.3.
  • During use of stent 20, expansion of expandable portions 36 may be achieved, for example, by application of a force which expands expandable portions 36 or by removal of a force which contracts expandable portions 36 as is further explained hereinbelow.
  • The force which expands the expandable portion 36 is suppliable by, for example, an inflatable balloon 40 of a catheter 38 receivable within hollow body 22 of stent 20 (FIG. 4). Catheter 38 may used to implant stent 20 into the body of a patient, for example via the femoral vein, through the superior vena cava and the right atrium to the coronary sinus. Guidance of catheter 38, whether a balloon catheter or any other type of catheter, may be effected under imaging. Imaging may be accomplished, for example, by computer assisted tomography (CT), magnetic resonance imaging (MRI), proton emission tomography (PET), ultrasonography, three dimensional ultrasonography, fluoroscopy, electrophysiological imaging, X-ray imagery or echocardiogaphy. After stent 20 has reached the desired position in lumen 28, the coronary sinus in this example, balloon 40 is inflated, thereby expanding expandable portion 36 and affixing stent 20 within lumen 28. Stent 20 may be fixed in place, for example, as a result of a physical contact 44 between a portion of stent 20 and an inner surface of lumen 28. Alternately, stent 20 may be fixed in place, as a result of a biological process occurring in cells of an inner surface of lumen 28 as a result of a presence therein of stent 20. Biological processes which would tend to fix stent 20 in place include, but are not limited to, secretion of a fluid, cell death, tissue growth, scarring, clotting, swelling and localized inflammation. After placement of stent 20, balloon 40 is deflated and withdrawn along with catheter 38. The end result of this process is that the effective cross sectional dimension of lumen 28 is reduced from its original size 34 to the size of inner cross sectional dimension 32 of hollow body 22 of stent 20.
  • An alternate method of affixing stent 20 in lumen 28 is illustrated in FIGS. 5 a-b. This method relies upon removal of a force which contracts expandable portion 36. In contrast to the balloon catheter method described hereinabove, this method employs a catheter 38 equipped with a piston 50. As shown in FIG. 5 a, stent 20 is inserted in catheter 38 in a collapsed position. In this case, stent 20 has at least one expandable portion 36 (two are pictured) having an inherent spring-like memory. Insertion and guidance are as described hereinabove for the balloon catheterization method. After stent 20 has reached the desired position in lumen 28, the coronary sinus in this example, piston 50 is translated as indicated by an arrow, while catheter 38 is retracted as indicated by a pair of arrows. Stent 20 is thereby ejected into lumen 28, where expandable portion 36, having an inherent spring-like memory, expands to affix stent 20 within lumen 28 (FIG. 5 b). As in the balloon catheterization method, the end result of this process is that the effective cross sectional dimension of lumen 28 is reduced from its original size 34 to the size of inner cross sectional dimension 32 of hollow body 22 of stent 20.
  • As can be seen in FIG. 6, regardless of the method chosen to place stent 20 in lumen 28, a flow passage 30 through lumen 28 is now limited by cross sectional dimension 32 of stent 20 and not by cross sectional dimension 34 of lumen 28. This limitation occurs as a result of contact 44 between stent 20 and lumen 28. Flow through holes 48 of expandable portion 36 is prevented by coating 46 on stent 20.
  • Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims. All publications cited herein are incorporated by reference in their entirety. Citation or identification of any reference in this section or in any other section of this application shall not be construed as an admission that such reference is available as prior art to the present invention.

Claims (16)

1. A method of affecting blood flow in coronary vessels, comprising:
(a) transvascularly guiding a catheter to a coronary sinus; and
(b) narrowing a cross-sectional dimension of a flow lumen of said coronary sinus using said catheter.
2. A method according to claim 1, wherein narrowing comprises deploying a flow reducer in said coronary sinus.
3. A method according to claim 2, wherein deploying comprises deploying using a balloon.
4. A method according to claim 2, wherein deploying comprises deploying a self-expanding reducer.
5. A method according to claim 1, wherein narrowing comprises narrowing in a manner that increases back pressure.
6. A method according to claim 1, wherein narrowing comprises narrowing in a manner that initiates angiogenesis.
7. A method according to claim 1, wherein narrowing comprises narrowing in a manner that accelerates angiogenesis.
8. A method according to claim 1, wherein narrowing comprises narrowing in a manner that prevents ischemic heart disease.
9. A method according to claim 1, wherein narrowing comprises permanently narrowing.
10. A method according to claim 1, comprising:
determining that a patient has ischemic heart disease; and
performing (a)-(b).
11. A method according to claim 1, comprising reducing said a diameter of said cross-section by a factor of at least 2.6.
12. A method of improving perfusion of a tissue, comprising:
(a) identifying a tissue having a deficient degree of blood flow there through; and
(b) transvascularly narrowing a cross-sectional diameter of a vessel carrying blood from said tissue.
13. A method according to claim 12, wherein said vessel comprises a coronary sinus.
14. A method according to claim 12, wherein said tissue comprises cardiac tissue.
15. A method according to claim 12, wherein said narrowing is sufficient to cause angiogenesis in said tissue.
16. A method according to claim 12, wherein narrowing comprises implanting a flow reducer in said vessel.
US11/186,745 2000-03-27 2005-07-21 Device and method for treating ischemic heart disease Abandoned US20050267567A1 (en)

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US11/186,745 Abandoned US20050267567A1 (en) 2000-03-27 2005-07-21 Device and method for treating ischemic heart disease
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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060167543A1 (en) * 1999-12-31 2006-07-27 Bailey Steven R Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20090177262A1 (en) * 2006-04-26 2009-07-09 Carlos Oberti Apparatus and method for treating cardiovascular diseases
US20100087907A1 (en) * 2007-02-16 2010-04-08 Emory University Apparatus And Methods For Treating The Aorta
US20110106244A1 (en) * 2008-01-25 2011-05-05 Markus Ferrari Medical apparatus for the therapeutic treatment of an insufficient cardiac valve
US8556954B2 (en) 2000-03-27 2013-10-15 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
US9114035B2 (en) * 2006-04-26 2015-08-25 The Cleveland Clinic Foundation Apparatus and method for treating cardiovascular diseases
US20150265350A1 (en) * 2014-03-24 2015-09-24 Terumo Kabushiki Kaisha Treatment device
US10993805B2 (en) 2008-02-26 2021-05-04 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11185405B2 (en) 2013-08-30 2021-11-30 Jenavalve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
US11337800B2 (en) 2015-05-01 2022-05-24 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US11357624B2 (en) 2007-04-13 2022-06-14 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US11517431B2 (en) 2005-01-20 2022-12-06 Jenavalve Technology, Inc. Catheter system for implantation of prosthetic heart valves
US11564794B2 (en) 2008-02-26 2023-01-31 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11589981B2 (en) 2010-05-25 2023-02-28 Jenavalve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US11723783B2 (en) 2019-01-23 2023-08-15 Neovasc Medical Ltd. Covered flow modifying apparatus

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709465B2 (en) 1999-03-18 2004-03-23 Fossa Medical, Inc. Radially expanding ureteral device
IL153753A0 (en) * 2002-12-30 2003-07-06 Neovasc Medical Ltd Varying-diameter vascular implant and balloon
US6953476B1 (en) * 2000-03-27 2005-10-11 Neovasc Medical Ltd. Device and method for treating ischemic heart disease
US20020032478A1 (en) * 2000-08-07 2002-03-14 Percardia, Inc. Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel
CA2708603C (en) * 2001-03-13 2015-02-17 Yoram Richter Method and apparatus for stenting
US6863683B2 (en) 2001-09-19 2005-03-08 Abbott Laboratoris Vascular Entities Limited Cold-molding process for loading a stent onto a stent delivery system
AU2003247526A1 (en) 2002-06-12 2003-12-31 Mitral Interventions, Inc. Method and apparatus for tissue connection
AU2003219503A1 (en) * 2002-08-08 2004-02-25 Neovasc Medical Ltd. Geometric flow regulator
US20060106449A1 (en) * 2002-08-08 2006-05-18 Neovasc Medical Ltd. Flow reducing implant
EP1549254A4 (en) * 2002-09-27 2007-11-07 Medlogics Device Corp Implantable stent with modified ends
US7875068B2 (en) * 2002-11-05 2011-01-25 Merit Medical Systems, Inc. Removable biliary stent
DE10362223B4 (en) * 2003-01-21 2010-02-04 pfm Produkte für die Medizin AG Basic coil shape
US9271825B2 (en) * 2003-02-06 2016-03-01 Mike Arkusz Pulsating stent graft
IL154531A (en) 2003-02-19 2006-04-10 Yair Tal Device and method for regulating blood flow
US7025779B2 (en) * 2003-02-26 2006-04-11 Scimed Life Systems, Inc. Endoluminal device having enhanced affixation characteristics
WO2004098459A1 (en) * 2003-04-30 2004-11-18 Rex Medical, L.P. Vein filter
US20050004647A1 (en) * 2003-07-03 2005-01-06 William Cook Europe Aps Hybrid stent apparatus
US20050070993A1 (en) * 2003-09-29 2005-03-31 Peter Boekstegers Methods of retroperfusion and related devices
IL158960A0 (en) 2003-11-19 2004-05-12 Neovasc Medical Ltd Vascular implant
JP4301935B2 (en) * 2003-12-26 2009-07-22 テルモ株式会社 Device for retaining embolus member
US8500774B2 (en) 2004-01-22 2013-08-06 Rex Medical, L.P. Vein filter
US9510929B2 (en) 2004-01-22 2016-12-06 Argon Medical Devices, Inc. Vein filter
US7704266B2 (en) 2004-01-22 2010-04-27 Rex Medical, L.P. Vein filter
US7976562B2 (en) 2004-01-22 2011-07-12 Rex Medical, L.P. Method of removing a vein filter
US8162972B2 (en) 2004-01-22 2012-04-24 Rex Medical, Lp Vein filter
US7998220B2 (en) * 2004-02-04 2011-08-16 Murphy Timothy P Methods for treating obesity
DE102004012351A1 (en) * 2004-03-11 2005-09-29 pfm Produkte für die Medizin AG Device for recanalizing a cavity, organ or vessel
WO2005087140A1 (en) 2004-03-11 2005-09-22 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
ITMO20040129A1 (en) * 2004-05-25 2004-08-25 G A M A H S S R L BLOOD VESSEL FILTER.
CA2575812C (en) * 2004-08-02 2015-03-17 Merkechten En Patenten Nederland B.V. (M.P.N.) Device and method for treating a vessel
CA2580124C (en) 2004-09-27 2014-05-13 Rex Medical, L.P. Vein filter
WO2006054107A2 (en) * 2004-11-19 2006-05-26 Medtronic Inc. Method and apparatus for treatment of cardiac valves
ES2764992T3 (en) 2005-04-04 2020-06-05 Flexible Stenting Solutions Inc Flexible stent
DE102005016103B4 (en) * 2005-04-08 2014-10-09 Merit Medical Systems, Inc. Duodenumstent
DE102005019649A1 (en) 2005-04-26 2006-11-02 Alveolus Inc. Flexible stent for positioning in lumen of esophagus comprises tube and stabilization members defined circumferentially about tube, where each member extends inwardly in tube to define inner diameter that is less than inner diameter of tube
EP1885288B1 (en) 2005-05-13 2015-03-18 Merit Medical Systems, Inc. Drainage stent and associated method
US10070977B2 (en) * 2005-05-24 2018-09-11 Inspire M.D. Ltd Stent apparatuses for treatment via body lumens and methods of use
US8961586B2 (en) * 2005-05-24 2015-02-24 Inspiremd Ltd. Bifurcated stent assemblies
US8043323B2 (en) 2006-10-18 2011-10-25 Inspiremd Ltd. In vivo filter assembly
DE102005032308A1 (en) * 2005-07-11 2007-01-18 Campus Gmbh & Co. Kg Endovascular implant for the occlusion of a blood vessel
CA2619429A1 (en) * 2005-08-22 2007-03-01 Incept, Llc Flared stents and apparatus and methods for making and using them
US8956400B2 (en) * 2005-10-14 2015-02-17 Flexible Stenting Solutions, Inc. Helical stent
CA2629534C (en) 2005-11-10 2015-02-24 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
US8828091B2 (en) * 2006-03-23 2014-09-09 Boston Scientific Scimed, Inc. Movable stent reinforcement
US8333000B2 (en) 2006-06-19 2012-12-18 Advanced Cardiovascular Systems, Inc. Methods for improving stent retention on a balloon catheter
US20090234431A1 (en) * 2006-08-22 2009-09-17 The Trustees Of Columbia University In The City Of New York Arteriovenous graft blood flow controllers and methods
US20080051879A1 (en) * 2006-08-23 2008-02-28 Cook Incorporated Methods of treating venous valve related conditions with a flow-modifying implantable medical device
US7643879B2 (en) * 2006-08-24 2010-01-05 Cardiac Pacemakers, Inc. Integrated cardiac rhythm management system with heart valve
US10076401B2 (en) 2006-08-29 2018-09-18 Argon Medical Devices, Inc. Vein filter
CN102836023B (en) 2006-10-18 2015-12-02 印斯拜尔Md有限公司 The support casing of braiding
WO2008062414A2 (en) 2006-11-22 2008-05-29 Inspiremd Ltd. Optimized stent jacket
WO2008066206A1 (en) * 2006-11-30 2008-06-05 Keio University Abnormal electrical conduction-blocking apparatus using photodynamic therapy (pdt)
US7988723B2 (en) 2007-08-02 2011-08-02 Flexible Stenting Solutions, Inc. Flexible stent
CN101152111B (en) * 2007-09-07 2010-07-14 中国人民解放军第四军医大学第一附属医院 Pulmonary artery coarctation bracket for pulmonary hypertension surgery treatment
US20090187211A1 (en) * 2007-12-21 2009-07-23 Abbott Laboratories Vena cava filter having hourglass shape
DE102008015781B4 (en) * 2008-03-26 2011-09-29 Malte Neuss Device for sealing defects in the vascular system
EP2282684B1 (en) * 2008-04-03 2016-06-15 Cook Medical Technologies LLC Occlusion device
US20090281379A1 (en) * 2008-05-12 2009-11-12 Xlumena, Inc. System and method for transluminal access
US9226820B2 (en) * 2008-07-15 2016-01-05 St. Jude Medical, Inc. Axially anchoring collapsible and re-expandable prosthetic heart valves for various disease states
US9820746B2 (en) * 2008-07-28 2017-11-21 Incube Laboratories LLC System and method for scaffolding anastomoses
CN102292053A (en) 2008-09-29 2011-12-21 卡迪尔克阀门技术公司 Heart valve
WO2010040009A1 (en) 2008-10-01 2010-04-08 Cardiaq Valve Technologies, Inc. Delivery system for vascular implant
US9149376B2 (en) 2008-10-06 2015-10-06 Cordis Corporation Reconstrainable stent delivery system
US9211202B2 (en) * 2008-10-24 2015-12-15 Wisconsin Alumni Research Foundation Apparatus and method for treating an aneurysm
US20100131049A1 (en) * 2008-11-24 2010-05-27 Medtronic Vascular, Inc. One-Way valve Prosthesis for Percutaneous Placement Within the Venous System
EP2196174B1 (en) 2008-12-12 2014-02-26 Abbott Laboratories Vascular Enterprises Limited Process for loading a stent onto a stent delivery system
US8888836B2 (en) * 2009-04-07 2014-11-18 Medtronic Vascular, Inc. Implantable temporary flow restrictor device
US9060891B2 (en) * 2009-04-07 2015-06-23 Medtronic Vascular, Inc. Implantable temporary flow restrictor device
EP4119098A1 (en) 2009-04-15 2023-01-18 Edwards Lifesciences CardiAQ LLC Vascular implant and delivery system
US8052737B2 (en) * 2009-05-05 2011-11-08 Medtronic Vascular, Inc. Implantable temporary flow restrictor device
US20120130467A1 (en) * 2009-07-24 2012-05-24 Selden Nathan R Interfacial stent and method of maintaining patency of surgical fenestrations
EP2868299B1 (en) 2009-08-24 2022-08-10 New Phase Ltd Phase change and shape change materials
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US20110106234A1 (en) * 2009-10-30 2011-05-05 Axel Grandt Interluminal medical treatment devices and methods
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
DE102009052002B4 (en) * 2009-11-05 2012-09-27 Acandis Gmbh & Co. Kg A medical device for recanalizing body cavities and set comprising such device
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US20110224785A1 (en) 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US8864811B2 (en) 2010-06-08 2014-10-21 Veniti, Inc. Bi-directional stent delivery system
US9301864B2 (en) 2010-06-08 2016-04-05 Veniti, Inc. Bi-directional stent delivery system
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
US9579193B2 (en) 2010-09-23 2017-02-28 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
EP3459500B1 (en) 2010-09-23 2020-09-16 Edwards Lifesciences CardiAQ LLC Replacement heart valves and delivery devices
US10321998B2 (en) 2010-09-23 2019-06-18 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
US9233014B2 (en) 2010-09-24 2016-01-12 Veniti, Inc. Stent with support braces
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
JP6162690B2 (en) * 2011-05-20 2017-07-12 ビーエフケイダブリュ・リミテッド・ライアビリティ・カンパニーBfkw, Llc Intraluminal device with increased anti-migration and intraluminal methods
EP2739214B1 (en) 2011-08-05 2018-10-10 Cardiovalve Ltd Percutaneous mitral valve replacement and sealing
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10238483B2 (en) * 2011-09-16 2019-03-26 3Dt Holdings, Llc Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment success
US9549817B2 (en) 2011-09-22 2017-01-24 Transmural Systems Llc Devices, systems and methods for repairing lumenal systems
KR101330397B1 (en) * 2011-11-01 2013-11-15 재단법인 아산사회복지재단 A device for blood vessel anastomosis using the self-expandable material or structure and a method for blood vessel anastomosis using the same
WO2013120082A1 (en) 2012-02-10 2013-08-15 Kassab Ghassan S Methods and uses of biological tissues for various stent and other medical applications
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
ES2687546T3 (en) * 2012-06-26 2018-10-25 V.V.T. Med Ltd. Occlusion and narrowing of biodegradable blood vessels
ES2647893T3 (en) 2012-06-26 2017-12-27 V.V.T. Med Ltd. Vascular occlusion devices
US9858387B2 (en) 2013-01-15 2018-01-02 CathWorks, LTD. Vascular flow assessment
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
AU2014214700B2 (en) 2013-02-11 2018-01-18 Cook Medical Technologies Llc Expandable support frame and medical device
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
ITRM20130271A1 (en) * 2013-05-07 2014-11-08 Fond Ptv Policlinico Tor Vergata SHUNT SURGICAL DEVICE
US10058315B2 (en) 2014-03-27 2018-08-28 Transmural Systems Llc Devices and methods for closure of transvascular or transcameral access ports
KR102493269B1 (en) * 2014-06-18 2023-01-27 보스톤 싸이엔티픽 싸이메드 인코포레이티드 Biliary stent
IL250181B1 (en) * 2014-07-20 2023-12-01 Bruckheimer Elchanan Pulmonary artery implant apparatus
WO2016016899A1 (en) 2014-07-30 2016-02-04 Mitraltech Ltd. Articulatable prosthetic valve
CH710439A1 (en) 2014-12-18 2016-06-30 Intellistent Ag Adjustable multi-lumen stent.
WO2016125160A1 (en) 2015-02-05 2016-08-11 Mitraltech Ltd. Prosthetic valve with axially-sliding frames
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
US20160346453A1 (en) * 2015-05-30 2016-12-01 Rex Medical, L.P. Vascular device
US10426482B2 (en) 2015-09-15 2019-10-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Devices and methods for effectuating percutaneous Glenn and Fontan procedures
EP3393372A4 (en) * 2015-12-22 2019-08-21 Prodeon, Inc. System and method for increasing a cross-sectional area of a body lumen
CN108882981B (en) 2016-01-29 2021-08-10 内奥瓦斯克迪亚拉公司 Prosthetic valve for preventing outflow obstruction
US10363130B2 (en) 2016-02-05 2019-07-30 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
CN105943198A (en) * 2016-05-24 2016-09-21 李雷 Combined stent used for TIPS operation
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
EP3848003A1 (en) 2016-08-10 2021-07-14 Cardiovalve Ltd. Prosthetic valve with concentric frames
US11771434B2 (en) 2016-09-28 2023-10-03 Restore Medical Ltd. Artery medical apparatus and methods of use thereof
WO2018090148A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US11432950B2 (en) 2017-03-23 2022-09-06 Nipro Corporation Stent
EP3624704A4 (en) * 2017-06-05 2021-03-10 Restore Medical Ltd Double walled fixed length stent like apparatus and methods of use thereof
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10595874B2 (en) 2017-09-21 2020-03-24 W. L. Gore & Associates, Inc. Multiple inflation endovascular medical device
GB201718299D0 (en) 2017-11-03 2017-12-20 Ab Wasstand Dev Stents
EP3703612A4 (en) * 2017-11-03 2021-08-18 The Brain Protection Company PTY Ltd Implantable damping device for modifying blood flow characteristics
CN109833521B (en) * 2017-11-29 2021-10-26 郑州大学 Method and device for preparing artificial blood vessel
GB201720803D0 (en) 2017-12-13 2018-01-24 Mitraltech Ltd Prosthetic Valve and delivery tool therefor
GB201800399D0 (en) 2018-01-10 2018-02-21 Mitraltech Ltd Temperature-control during crimping of an implant
WO2019190917A1 (en) * 2018-03-29 2019-10-03 Boston Scientific Scimed, Inc. Flow control valve
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
CN114025716A (en) 2019-02-07 2022-02-08 Nxt生物医疗有限责任公司 Rivet diverter and deployment method
MX2021009918A (en) * 2019-02-17 2022-06-24 Aorto Medical LLC Flow restricting stent-graft.
CA3135753C (en) 2019-04-01 2023-10-24 Neovasc Tiara Inc. Controllably deployable prosthetic valve
CA3136334A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
WO2020236931A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
CN114144144A (en) 2019-06-20 2022-03-04 内奥瓦斯克迪亚拉公司 Low-profile prosthetic mitral valve
CN110403732B (en) * 2019-07-04 2022-06-03 李娅娜 A vein ring contracts tectorial membrane support device for myocardial ischemia coronary vein blood vessel
WO2021178401A1 (en) * 2020-03-03 2021-09-10 The Regents Of The University Of California Cerebral dural venous sinus stent
WO2021226014A2 (en) * 2020-05-04 2021-11-11 Vahaticor Llc Vascular flow and pressure modulator

Citations (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US571639A (en) * 1896-11-17 Sounding device
US3620218A (en) * 1963-10-31 1971-11-16 American Cyanamid Co Cylindrical prosthetic devices of polyglycolic acid
US4106129A (en) * 1976-01-09 1978-08-15 American Hospital Supply Corporation Supported bioprosthetic heart valve with compliant orifice ring
US4297749A (en) * 1977-04-25 1981-11-03 Albany International Corp. Heart valve prosthesis
US4494531A (en) * 1982-12-06 1985-01-22 Cook, Incorporated Expandable blood clot filter
US4501263A (en) * 1982-03-31 1985-02-26 Harbuck Stanley C Method for reducing hypertension of a liver
US4601718A (en) * 1982-12-13 1986-07-22 Possis Medical, Inc. Vascular graft and blood supply method
US4727873A (en) * 1984-04-17 1988-03-01 Mobin Uddin Kazi Embolus trap
US4994066A (en) * 1988-10-07 1991-02-19 Voss Gene A Prostatic stent
US5007926A (en) * 1989-02-24 1991-04-16 The Trustees Of The University Of Pennsylvania Expandable transluminally implantable tubular prosthesis
US5026377A (en) * 1989-07-13 1991-06-25 American Medical Systems, Inc. Stent placement instrument and method
US5064435A (en) * 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5078736A (en) * 1990-05-04 1992-01-07 Interventional Thermodynamics, Inc. Method and apparatus for maintaining patency in the body passages
US5129902A (en) * 1990-04-20 1992-07-14 Marlowe Goble E Endosteal ligament retainer and process
US5201757A (en) * 1992-04-03 1993-04-13 Schneider (Usa) Inc. Medial region deployment of radially self-expanding stents
US5246445A (en) * 1990-04-19 1993-09-21 Instent Inc. Device for the treatment of constricted ducts in human bodies
US5282823A (en) * 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5304194A (en) * 1991-10-02 1994-04-19 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
US5330482A (en) * 1991-06-17 1994-07-19 Wilson-Cook Medical Inc. Endoscopic extraction devices, wire basket stone extractors, stent retrievers, snares and method of constructing the same
US5342348A (en) * 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
US5354309A (en) * 1991-10-11 1994-10-11 Angiomed Ag Apparatus for widening a stenosis in a body cavity
US5375612A (en) * 1992-04-07 1994-12-27 B. Braun Celsa Possibly absorbable blood filter
US5382261A (en) * 1992-09-01 1995-01-17 Expandable Grafts Partnership Method and apparatus for occluding vessels
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5409019A (en) * 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
US5476506A (en) * 1994-02-08 1995-12-19 Ethicon, Inc. Bi-directional crimped graft
US5514176A (en) * 1995-01-20 1996-05-07 Vance Products Inc. Pull apart coil stent
US5554185A (en) * 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5575818A (en) * 1995-02-14 1996-11-19 Corvita Corporation Endovascular stent with locking ring
US5609627A (en) * 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5618301A (en) * 1993-10-07 1997-04-08 Angiomed Ag Reducing stent, device with reducing stent and use of a reducing stent
US5645551A (en) * 1989-07-18 1997-07-08 United States Surgical Corporation Apparatus and method for applying surgical clips
US5653744A (en) * 1995-04-27 1997-08-05 Khouri Biomedical Research, Inc. Device and method for vascular anastomosis
US5655548A (en) * 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5662713A (en) * 1991-10-09 1997-09-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5683411A (en) * 1994-04-06 1997-11-04 William Cook Europe A/S Medical article for implantation into the vascular system of a patient
US5695504A (en) * 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5709335A (en) * 1994-06-17 1998-01-20 Heartport, Inc. Surgical stapling instrument and method thereof
US5713908A (en) * 1995-01-09 1998-02-03 Jameel; Irfan Mufty Laparascopic suturing instrument
US5732872A (en) * 1994-06-17 1998-03-31 Heartport, Inc. Surgical stapling instrument
US5741333A (en) * 1995-04-12 1998-04-21 Corvita Corporation Self-expanding stent for a medical device to be introduced into a cavity of a body
US5755769A (en) * 1992-03-12 1998-05-26 Laboratoire Perouse Implant Expansible endoprosthesis for a human or animal tubular organ, and fitting tool for use thereof
US5755779A (en) * 1995-12-07 1998-05-26 Horiguchi; Sachio Blood stream adjuster
US5772668A (en) * 1992-06-18 1998-06-30 American Biomed, Inc. Apparatus for placing an endoprosthesis
US5782905A (en) * 1996-05-03 1998-07-21 Zuli Holdings Ltd. Endovascular device for protection of aneurysm
US5782844A (en) * 1996-03-05 1998-07-21 Inbae Yoon Suture spring device applicator
US5797930A (en) * 1996-12-26 1998-08-25 Dan Siev Surgical implement and method of suturing
US5810850A (en) * 1992-10-19 1998-09-22 Indiana University Foundation Apparatus and method for positive closure of an internal tissue membrane opening
US5843117A (en) * 1996-02-14 1998-12-01 Inflow Dynamics Inc. Implantable vascular and endoluminal stents and process of fabricating the same
US5873906A (en) * 1994-09-08 1999-02-23 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US5876445A (en) * 1991-10-09 1999-03-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5876418A (en) * 1994-01-13 1999-03-02 Angiomed Ag Device for providing a duct in a living body
US5897588A (en) * 1997-03-14 1999-04-27 Hull; Cheryl C. Coronary stent and method of fabricating same
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6015432A (en) * 1998-02-25 2000-01-18 Cordis Corporation Wire reinforced vascular prosthesis
US6053873A (en) * 1997-01-03 2000-04-25 Biosense, Inc. Pressure-sensing stent
US6070589A (en) * 1997-08-01 2000-06-06 Teramed, Inc. Methods for deploying bypass graft stents
US6071292A (en) * 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US6110198A (en) * 1995-10-03 2000-08-29 Medtronic Inc. Method for deploying cuff prostheses
US6120534A (en) * 1997-10-29 2000-09-19 Ruiz; Carlos E. Endoluminal prosthesis having adjustable constriction
US6159156A (en) * 1997-08-15 2000-12-12 Rijksuniversiteit Leiden Pressure sensor for use in an artery
US6168614B1 (en) * 1990-05-18 2001-01-02 Heartport, Inc. Valve prosthesis for implantation in the body
US6254627B1 (en) * 1997-09-23 2001-07-03 Diseno Y Desarrollo Medico S.A. De C.V. Non-thrombogenic stent jacket
US6277082B1 (en) * 1999-07-22 2001-08-21 C. R. Bard, Inc. Ischemia detection system
US20010021872A1 (en) * 1999-12-31 2001-09-13 Bailey Steven R. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6296603B1 (en) * 1998-05-26 2001-10-02 Isostent, Inc. Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms
US6348066B1 (en) * 1995-11-07 2002-02-19 Corvita Corporation Modular endoluminal stent-grafts and methods for their use
US6447539B1 (en) * 1996-09-16 2002-09-10 Transvascular, Inc. Method and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion
US6579306B1 (en) * 1998-01-14 2003-06-17 Klinikum Mannheim Ggmbh Expansion catheter for bypass surgery including two expansion zones and therebetween an intermediate constriction

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334629A (en) * 1964-11-09 1967-08-08 Bertram D Cohn Occlusive device for inferior vena cava
US4047252A (en) 1976-01-29 1977-09-13 Meadox Medicals, Inc. Double-velour synthetic vascular graft
US4292974A (en) * 1980-01-30 1981-10-06 Thomas J. Fogarty Dilatation catheter apparatus and method
US4705517A (en) * 1985-09-03 1987-11-10 Becton, Dickinson And Company Percutaneously deliverable intravascular occlusion prosthesis
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5102417A (en) * 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
CH668192A5 (en) * 1985-11-29 1988-12-15 Schneider Medintag Ag CATHETER FOR TREATING NARROW BODIES, FOR EXAMPLE IN A BLOOD VESSEL.
US4893623A (en) 1986-12-09 1990-01-16 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
US4813934A (en) * 1987-08-07 1989-03-21 Target Therapeutics Valved catheter device and method
US6730105B2 (en) * 1988-07-29 2004-05-04 Samuel Shiber Clover leaf shaped tubular medical device
DK0474748T3 (en) * 1989-05-31 1995-05-01 Baxter Int Biological flap prosthesis
ATE120377T1 (en) 1990-02-08 1995-04-15 Howmedica INFLATABLE DILATATOR.
DE4018525C2 (en) * 1990-06-09 1994-05-05 Kaltenbach Martin Expandable area catheter
DE9014230U1 (en) 1990-10-13 1991-11-21 Angiomed Ag, 7500 Karlsruhe, De
DE69116130T2 (en) 1990-10-18 1996-05-15 Ho Young Song SELF-EXPANDING, ENDOVASCULAR DILATATOR
US5380316A (en) * 1990-12-18 1995-01-10 Advanced Cardiovascular Systems, Inc. Method for intra-operative myocardial device revascularization
US5304220A (en) * 1991-07-03 1994-04-19 Maginot Thomas J Method and apparatus for implanting a graft prosthesis in the body of a patient
US5222980A (en) * 1991-09-27 1993-06-29 Medtronic, Inc. Implantable heart-assist device
US5211658A (en) 1991-11-05 1993-05-18 New England Deaconess Hospital Corporation Method and device for performing endovascular repair of aneurysms
US5209727A (en) * 1992-01-29 1993-05-11 Interventional Technologies, Inc. Guide wire with integral angioplasty balloon
US5405377A (en) 1992-02-21 1995-04-11 Endotech Ltd. Intraluminal stent
US5336178A (en) * 1992-11-02 1994-08-09 Localmed, Inc. Intravascular catheter with infusion array
US5425765A (en) * 1993-06-25 1995-06-20 Tiefenbrun; Jonathan Surgical bypass method
US5464449A (en) * 1993-07-08 1995-11-07 Thomas J. Fogarty Internal graft prosthesis and delivery system
DE4418336A1 (en) 1994-05-26 1995-11-30 Angiomed Ag Stent for widening and holding open receptacles
US5397355A (en) * 1994-07-19 1995-03-14 Stentco, Inc. Intraluminal stent
US5653743A (en) * 1994-09-09 1997-08-05 Martin; Eric C. Hypogastric artery bifurcation graft and method of implantation
US6579314B1 (en) * 1995-03-10 2003-06-17 C.R. Bard, Inc. Covered stent with encapsulated ends
DE19509464C1 (en) * 1995-03-20 1996-06-27 Horst J Dr Med Jaeger Implant for artery or vein, with anchor piece fixed to wall of vessel
US5620439A (en) * 1995-06-06 1997-04-15 George S. Abela Catheter and technique for endovascular myocardial revascularization
FR2739783B1 (en) * 1995-10-13 1998-01-23 Ela Medical Sa DEFIBRILLATOR / ACTIVE IMPLANTABLE CARDIOVERVER MEDICAL DEVICE WITH HEADSET DEFIBRILLATION
US5840008A (en) * 1995-11-13 1998-11-24 Localmed, Inc. Radiation emitting sleeve catheter and methods
NL1001878C2 (en) 1995-12-12 1997-06-17 Cordis Europ A method of manufacturing a stent and a tubular member and catheter therefor.
US5797935A (en) * 1996-09-26 1998-08-25 Interventional Technologies Inc. Balloon activated forced concentrators for incising stenotic segments
US5870081A (en) * 1996-10-03 1999-02-09 Primax Electronics Ltd. Mouse housing structure
US6015431A (en) * 1996-12-23 2000-01-18 Prograft Medical, Inc. Endolumenal stent-graft with leak-resistant seal
GB9706766D0 (en) 1997-04-03 1997-05-21 Sulzer Vascutek Ltd Endovascular prostheses
AU744343B2 (en) 1997-04-11 2002-02-21 Transvascular, Inc. Methods and apparatus for transmyocardial direct coronary revascularization
US6013055A (en) * 1997-11-13 2000-01-11 Boston Scientific Corporation Catheter balloon having selected folding characteristics
SG71881A1 (en) 1998-01-08 2000-04-18 Microsense Cardiovascular Sys Method and device for fixation of a sensor in a bodily lumen
US6264687B1 (en) * 1998-04-20 2001-07-24 Cordis Corporation Multi-laminate stent having superelastic articulated sections
US6325813B1 (en) 1998-08-18 2001-12-04 Scimed Life Systems, Inc. Method and apparatus for stabilizing vascular wall
WO2000032092A1 (en) 1998-11-25 2000-06-08 Ball Semiconductor, Inc. Intraluminal monitoring system
US6129706A (en) * 1998-12-10 2000-10-10 Janacek; Jaroslav Corrugated catheter balloon
US6364903B2 (en) * 1999-03-19 2002-04-02 Meadox Medicals, Inc. Polymer coated stent
US6293968B1 (en) 1999-09-02 2001-09-25 Syde A. Taheri Inflatable intraluminal vascular stent
US6334866B1 (en) * 2000-01-14 2002-01-01 William H. Wall Stent device for performing endovascular repair of aneurysms
US6953476B1 (en) * 2000-03-27 2005-10-11 Neovasc Medical Ltd. Device and method for treating ischemic heart disease
CA2981561C (en) * 2001-10-04 2020-08-25 Neovasc Medical Ltd. Flow reducing implant
US7985234B2 (en) * 2002-02-27 2011-07-26 Boston Scientific Scimed, Inc. Medical device
US20060106449A1 (en) * 2002-08-08 2006-05-18 Neovasc Medical Ltd. Flow reducing implant
AU2003219503A1 (en) * 2002-08-08 2004-02-25 Neovasc Medical Ltd. Geometric flow regulator
US7422595B2 (en) * 2003-01-17 2008-09-09 Scion Cardio-Vascular, Inc. Proximal actuator for medical device

Patent Citations (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US571639A (en) * 1896-11-17 Sounding device
US3620218A (en) * 1963-10-31 1971-11-16 American Cyanamid Co Cylindrical prosthetic devices of polyglycolic acid
US4106129A (en) * 1976-01-09 1978-08-15 American Hospital Supply Corporation Supported bioprosthetic heart valve with compliant orifice ring
US4297749A (en) * 1977-04-25 1981-11-03 Albany International Corp. Heart valve prosthesis
US4501263A (en) * 1982-03-31 1985-02-26 Harbuck Stanley C Method for reducing hypertension of a liver
US4494531A (en) * 1982-12-06 1985-01-22 Cook, Incorporated Expandable blood clot filter
US4601718A (en) * 1982-12-13 1986-07-22 Possis Medical, Inc. Vascular graft and blood supply method
US4727873A (en) * 1984-04-17 1988-03-01 Mobin Uddin Kazi Embolus trap
US4994066A (en) * 1988-10-07 1991-02-19 Voss Gene A Prostatic stent
US5007926A (en) * 1989-02-24 1991-04-16 The Trustees Of The University Of Pennsylvania Expandable transluminally implantable tubular prosthesis
US5026377A (en) * 1989-07-13 1991-06-25 American Medical Systems, Inc. Stent placement instrument and method
US5645551A (en) * 1989-07-18 1997-07-08 United States Surgical Corporation Apparatus and method for applying surgical clips
US5246445A (en) * 1990-04-19 1993-09-21 Instent Inc. Device for the treatment of constricted ducts in human bodies
US5129902A (en) * 1990-04-20 1992-07-14 Marlowe Goble E Endosteal ligament retainer and process
US5078736A (en) * 1990-05-04 1992-01-07 Interventional Thermodynamics, Inc. Method and apparatus for maintaining patency in the body passages
US6168614B1 (en) * 1990-05-18 2001-01-02 Heartport, Inc. Valve prosthesis for implantation in the body
US5064435A (en) * 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5330482A (en) * 1991-06-17 1994-07-19 Wilson-Cook Medical Inc. Endoscopic extraction devices, wire basket stone extractors, stent retrievers, snares and method of constructing the same
US5304194A (en) * 1991-10-02 1994-04-19 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
US5662713A (en) * 1991-10-09 1997-09-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5876445A (en) * 1991-10-09 1999-03-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5354309A (en) * 1991-10-11 1994-10-11 Angiomed Ag Apparatus for widening a stenosis in a body cavity
US5755769A (en) * 1992-03-12 1998-05-26 Laboratoire Perouse Implant Expansible endoprosthesis for a human or animal tubular organ, and fitting tool for use thereof
US5282823A (en) * 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5201757A (en) * 1992-04-03 1993-04-13 Schneider (Usa) Inc. Medial region deployment of radially self-expanding stents
US5375612A (en) * 1992-04-07 1994-12-27 B. Braun Celsa Possibly absorbable blood filter
US5772668A (en) * 1992-06-18 1998-06-30 American Biomed, Inc. Apparatus for placing an endoprosthesis
US5382261A (en) * 1992-09-01 1995-01-17 Expandable Grafts Partnership Method and apparatus for occluding vessels
US5810850A (en) * 1992-10-19 1998-09-22 Indiana University Foundation Apparatus and method for positive closure of an internal tissue membrane opening
US5409019A (en) * 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
US5342348A (en) * 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
US5618301A (en) * 1993-10-07 1997-04-08 Angiomed Ag Reducing stent, device with reducing stent and use of a reducing stent
US5876418A (en) * 1994-01-13 1999-03-02 Angiomed Ag Device for providing a duct in a living body
US5476506A (en) * 1994-02-08 1995-12-19 Ethicon, Inc. Bi-directional crimped graft
US5609627A (en) * 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5683411A (en) * 1994-04-06 1997-11-04 William Cook Europe A/S Medical article for implantation into the vascular system of a patient
US5709335A (en) * 1994-06-17 1998-01-20 Heartport, Inc. Surgical stapling instrument and method thereof
US5732872A (en) * 1994-06-17 1998-03-31 Heartport, Inc. Surgical stapling instrument
US5554185A (en) * 1994-07-18 1996-09-10 Block; Peter C. Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same
US5873906A (en) * 1994-09-08 1999-02-23 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
US5713908A (en) * 1995-01-09 1998-02-03 Jameel; Irfan Mufty Laparascopic suturing instrument
US5514176A (en) * 1995-01-20 1996-05-07 Vance Products Inc. Pull apart coil stent
US5575818A (en) * 1995-02-14 1996-11-19 Corvita Corporation Endovascular stent with locking ring
US5695504A (en) * 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5741333A (en) * 1995-04-12 1998-04-21 Corvita Corporation Self-expanding stent for a medical device to be introduced into a cavity of a body
US5653744A (en) * 1995-04-27 1997-08-05 Khouri Biomedical Research, Inc. Device and method for vascular anastomosis
US6110198A (en) * 1995-10-03 2000-08-29 Medtronic Inc. Method for deploying cuff prostheses
US6348066B1 (en) * 1995-11-07 2002-02-19 Corvita Corporation Modular endoluminal stent-grafts and methods for their use
US5755779A (en) * 1995-12-07 1998-05-26 Horiguchi; Sachio Blood stream adjuster
US5843117A (en) * 1996-02-14 1998-12-01 Inflow Dynamics Inc. Implantable vascular and endoluminal stents and process of fabricating the same
US5782844A (en) * 1996-03-05 1998-07-21 Inbae Yoon Suture spring device applicator
US5782905A (en) * 1996-05-03 1998-07-21 Zuli Holdings Ltd. Endovascular device for protection of aneurysm
US6447539B1 (en) * 1996-09-16 2002-09-10 Transvascular, Inc. Method and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion
US5655548A (en) * 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5797930A (en) * 1996-12-26 1998-08-25 Dan Siev Surgical implement and method of suturing
US6053873A (en) * 1997-01-03 2000-04-25 Biosense, Inc. Pressure-sensing stent
US5897588A (en) * 1997-03-14 1999-04-27 Hull; Cheryl C. Coronary stent and method of fabricating same
US6071292A (en) * 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US6070589A (en) * 1997-08-01 2000-06-06 Teramed, Inc. Methods for deploying bypass graft stents
US6159156A (en) * 1997-08-15 2000-12-12 Rijksuniversiteit Leiden Pressure sensor for use in an artery
US6254627B1 (en) * 1997-09-23 2001-07-03 Diseno Y Desarrollo Medico S.A. De C.V. Non-thrombogenic stent jacket
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
US6120534A (en) * 1997-10-29 2000-09-19 Ruiz; Carlos E. Endoluminal prosthesis having adjustable constriction
US6579306B1 (en) * 1998-01-14 2003-06-17 Klinikum Mannheim Ggmbh Expansion catheter for bypass surgery including two expansion zones and therebetween an intermediate constriction
US6015432A (en) * 1998-02-25 2000-01-18 Cordis Corporation Wire reinforced vascular prosthesis
US6296603B1 (en) * 1998-05-26 2001-10-02 Isostent, Inc. Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms
US6277082B1 (en) * 1999-07-22 2001-08-21 C. R. Bard, Inc. Ischemia detection system
US20010021872A1 (en) * 1999-12-31 2001-09-13 Bailey Steven R. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992597B2 (en) 1999-12-31 2015-03-31 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US7799069B2 (en) * 1999-12-31 2010-09-21 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20060167543A1 (en) * 1999-12-31 2006-07-27 Bailey Steven R Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US9421100B2 (en) 1999-12-31 2016-08-23 ABPS Venture One, Ltd., a wholly owned subsidiary of Palmaz Scientific, Inc. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US11497503B2 (en) 2000-03-27 2022-11-15 Neovasc Medical Ltd. Methods for treating abnormal growths in the body using a flow reducing implant
US10542994B2 (en) 2000-03-27 2020-01-28 Neovasc Medical Ltd. Methods for treating abnormal growths in the body using a flow reducing implant
US8556954B2 (en) 2000-03-27 2013-10-15 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
US8858612B2 (en) 2000-03-27 2014-10-14 Neovasc Medical Inc. Methods for treating abnormal growths in the body using a flow reducing implant
US9364354B2 (en) 2000-03-27 2016-06-14 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
US11517431B2 (en) 2005-01-20 2022-12-06 Jenavalve Technology, Inc. Catheter system for implantation of prosthetic heart valves
US9114035B2 (en) * 2006-04-26 2015-08-25 The Cleveland Clinic Foundation Apparatus and method for treating cardiovascular diseases
US8652201B2 (en) * 2006-04-26 2014-02-18 The Cleveland Clinic Foundation Apparatus and method for treating cardiovascular diseases
US20090177262A1 (en) * 2006-04-26 2009-07-09 Carlos Oberti Apparatus and method for treating cardiovascular diseases
US20100087907A1 (en) * 2007-02-16 2010-04-08 Emory University Apparatus And Methods For Treating The Aorta
US11357624B2 (en) 2007-04-13 2022-06-14 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US8758430B2 (en) * 2008-01-25 2014-06-24 Jenavalve Technology, Inc. Medical apparatus for the therapeutic treatment of an insufficient cardiac valve
US20110106244A1 (en) * 2008-01-25 2011-05-05 Markus Ferrari Medical apparatus for the therapeutic treatment of an insufficient cardiac valve
US10993805B2 (en) 2008-02-26 2021-05-04 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11154398B2 (en) 2008-02-26 2021-10-26 JenaValve Technology. Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11564794B2 (en) 2008-02-26 2023-01-31 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US11589981B2 (en) 2010-05-25 2023-02-28 Jenavalve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US11185405B2 (en) 2013-08-30 2021-11-30 Jenavalve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
US10835317B2 (en) * 2014-03-24 2020-11-17 Terumo Kabushiki Kaisha Treatment device
US20150265350A1 (en) * 2014-03-24 2015-09-24 Terumo Kabushiki Kaisha Treatment device
US11337800B2 (en) 2015-05-01 2022-05-24 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US11065138B2 (en) 2016-05-13 2021-07-20 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
US11197754B2 (en) 2017-01-27 2021-12-14 Jenavalve Technology, Inc. Heart valve mimicry
US11723783B2 (en) 2019-01-23 2023-08-15 Neovasc Medical Ltd. Covered flow modifying apparatus

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ATE460141T1 (en) 2010-03-15
US20100179643A1 (en) 2010-07-15
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CA2404330A1 (en) 2001-10-04
WO2001072239A3 (en) 2002-03-28
US6953476B1 (en) 2005-10-11
EP1276437A2 (en) 2003-01-22
ES2343002T3 (en) 2010-07-21
US20030097172A1 (en) 2003-05-22
DE60141511D1 (en) 2010-04-22
WO2001072239A2 (en) 2001-10-04
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AU4678101A (en) 2001-10-08
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BR0109681A (en) 2004-06-22
DK1276437T3 (en) 2010-07-05

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