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Numéro de publicationUS20060052867 A1
Type de publicationDemande
Numéro de demandeUS 10/935,730
Date de publication9 mars 2006
Date de dépôt7 sept. 2004
Date de priorité7 sept. 2004
Autre référence de publicationEP1804726A1, EP1804726B1, EP2455042A2, EP2455042A3, US8591570, US9480556, US20080161910, US20080161911, US20140052242, WO2006029062A1
Numéro de publication10935730, 935730, US 2006/0052867 A1, US 2006/052867 A1, US 20060052867 A1, US 20060052867A1, US 2006052867 A1, US 2006052867A1, US-A1-20060052867, US-A1-2006052867, US2006/0052867A1, US2006/052867A1, US20060052867 A1, US20060052867A1, US2006052867 A1, US2006052867A1
InventeursJose Revuelta, Jack Lemmon, Timothy Ryan
Cessionnaire d'origineMedtronic, Inc
Exporter la citationBiBTeX, EndNote, RefMan
Liens externes: USPTO, Cession USPTO, Espacenet
Replacement prosthetic heart valve, system and method of implant
US 20060052867 A1
Résumé
A method of functionally replacing a previously implanted prosthetic heart valve. The method includes positioning a replacement prosthetic heart valve within an internal region defined by the previously implanted prosthetic heart valve. The replacement prosthetic heart valve is then physically docked to the previously implanted prosthetic heart valve. With this technique, the previously implanted prosthetic heart valve serves as a platform for securement of the replacement prosthetic heart valve to the patient's native tissue.
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Revendications(40)
1. A method of functionally replacing a previously implanted prosthetic heart valve, the method comprising:
positioning a replacement prosthetic heart valve within an internal region defined by the previously implanted prosthetic heart valve; and
physically docking the replacement prosthetic heart valve to the previously implanted prosthetic heart valve.
2. The method of claim 1, wherein following fastening, the replacement prosthetic heart valve is anchored relative to native bodily tissue via the previously implanted prosthetic heart valve.
3. The method of claim 1, wherein physically docking the replacement prosthetic heart valve to the previously implanted prosthetic heart valve is characterized by a physical connection apart from an interface provided by a radial pressure of the replacement prosthetic heart valve along an axial length of the previously implanted prosthetic heart valve.
4. The method of claim 1, wherein the replacement prosthetic heart valve includes valve leaflets, and further wherein following fastening, the valve leaflets of the replacement prosthetic heart valve function as natural valve leaflet replacements.
5. The method of claim 4, wherein the previously implanted prosthetic heart valve includes valve leaflets, the method further comprising:
preventing movement of the valve leaflets of the previously implanted prosthetic heart valve.
6. The method of claim 1, wherein the replacement prosthetic heart valve includes a support structure transitionable from a collapsed state to an expanded state, and further wherein the step of positioning the replacement prosthetic heart valve with the previously implanted prosthetic heart valve includes deploying the support structure in the collapsed state.
7. The method of claim 6, further comprising:
transitioning the support structure to the expanded state following the step of positioning the replacement prosthetic heart valve within the previously implanted prosthetic heart valve.
8. The method of claim 1, wherein the replacement prosthetic heart valve includes coupling means, and further wherein physically docking the replacement prosthetic heart valve includes:
securing the coupling means to the previously implanted prosthetic heart valve.
9. The method of claim 8, wherein the coupling means includes an anchor, and further wherein securing the coupling means includes:
attaching the anchor to an inflow side of the previously implanted prosthetic heart valve.
10. The method of claim 9, wherein attaching the anchor includes piercing a surface of the previously implanted prosthetic heart valve.
11. The method of claim 8, wherein the coupling means includes an anchor, and further wherein securing the coupling means includes:
attaching the anchor to an outflow side of the previously implanted prosthetic heart valve.
12. The method of claim 11, wherein the coupling means includes a second anchor, and further wherein securing the coupling means includes:
attaching the second anchor to the inflow side of the previously implanted prosthetic heart valve.
13. The method of claim 8, wherein the coupling means includes a component selected from the group consisting of a barb, clip, staple, eyelet, tab, and hook.
14. The method of claim 8, wherein the replacement prosthetic heart valve includes a support structure transitionable from a contracted state to an expanded state, an end portion of the support structure defining an increased diameter as compared to an intermediate portion in the expanded state, and further wherein the coupling means includes the enlarged diameter end portion and further wherein securing the coupling means includes:
transitioning the support structure to the expanded state; and
lodging the enlarged end portion against the previously implanted prosthetic heart valve.
15. The method of claim 14, wherein the coupling means includes opposing end portions of the support structure having enlarged diameters in the expanded state, and further wherein securing the coupling means further includes:
capturing the previously implanted heart valve between the opposing end portions.
16. The method of claim 1, further comprising:
deploying a gasket material between the previously implanted prosthetic heart valve and the replacement prosthetic heart valve prior to the step of physically docking the replacement prosthetic heart valve.
17. The method of claim 1, further comprising:
deploying a second replacement prosthetic heart valve within an internal region defined by the replacement prosthetic heart valve; and
physically docking the second replacement prosthetic heart valve to the previously implanted prosthetic heart valve.
18. The method of claim 1, wherein the previously implanted prosthetic heart valve includes connection means and the replacement prosthetic heart valve includes coupling means, and further wherein physically docking the replacement prosthetic heart valve to the previously implanted prosthetic heart valve includes securing the coupling means to the connection means.
19. A prosthetic heart valve for functionally replacing a previously implanted prosthetic heart valve, the prosthetic heart valve comprising:
a support structure;
leaflets mounted to the support structure;
coupling means associated with the support structure and adapted to physically dock the prosthetic heart valve to a previously implanted heart valve.
20. The prosthetic heart valve of claim 19, wherein the support structure is a stent.
21. The prosthetic heart valve of claim 20, wherein the stent is transitionable from a collapsed state to an expanded state having an enlarged diameter as compared to the collapsed state.
22. The prosthetic heart valve of claim 21, wherein the coupling means is defined, at least in part, by the stent in the expanded state in which at least one end portion of the stent defines an enlarged diameter as compared to a diameter of an intermediate portion of the stent.
23. The prosthetic heart valve of claim 19, wherein the coupling means is attached to the stent.
24. The prosthetic heart valve of claim 23, wherein the coupling means includes an anchor component consisting of a barb, clip, staple, post, eyelet, and hook.
25. The prosthetic heart valve of claim 19, wherein the coupling means is adapted to retract radially in the collapsed state and extend radially in the expanded state.
26. The prosthetic heart valve of claim 19, wherein the leaflets are formed from a material selected from the group consisting of autologous tissue, xenograph material, and synthetic.
27. The prosthetic heart valve of claim 19, wherein the coupling means extends radially outwardly relative to the leaflets.
28. The prosthetic heart valve of claim 19, further comprising:
a gasket material mounted to an exterior of the support structure.
29. A prosthetic heart valve comprising:
a support structure;
leaflets mounted to the support structure; and
connection means associated with the support structure and adapted to effectuate physical docking of a replacement heart valve to the prosthetic heart valve.
30. The prosthetic heart valve of claim 29, wherein the connection means includes a component selected from the group consisting of a rib, hook, barb, eyelet, ring, clip and staple.
31. The prosthetic heart valve of claim 29, wherein the support structure includes a covering material to which the leaflets are attached, and further wherein the connection means extends from the covering material.
32. The prosthetic heart valve of claim 29, wherein the support structure defines a sewing ring, and further wherein at least a portion of the connection means extends from the sewing ring.
33. The prosthetic heart valve of claim 29, wherein the support structure defines stent posts, and further wherein at least a portion of the connection means extends from the stent posts.
34. The prosthetic heart valve of claim 33, wherein the connection means includes a plurality of protrusions, respective ones of which extend from respective ones of the stent posts.
35. A prosthetic heart valve system comprising:
a first prosthetic heart valve for initial implantation to native heart tissue and including:
a support structure,
leaflets mounted to the support structure,
connection means associated with the support structure; and
a replacement prosthetic heart valve for functionally replacing the first prosthetic heart valve following implant of the first prosthetic heart valve, the replacement prosthetic heart valve including:
a support structure,
leaflets mounted to the support structure,
coupling means associated with the support structure;
wherein the connection means and the coupling means are configured such that the coupling means engages the connection means to physically dock the replacement prosthetic heart valve to the first prosthetic heart valve.
36. The system of claim 35, wherein the connection means and the coupling means include complimentary components.
37. The system of claim 35, wherein the connection means includes a ring and the coupling means includes a protrusion adapted to engage the ring.
38. The system of claim 35, wherein the connection means includes a component extending from an inflow side of the first prosthetic heart valve and the coupling means includes a component extending from an inflow side of the replacement prosthetic heart valve.
39. The system of claim 35, wherein the connection means includes a component extending form an outflow side of the first prosthetic heart valve and the coupling means includes a component extending from an outflow side of the replacement prosthetic heart valve.
40. The system of claim 35, wherein the connection means and coupling means are adapted to provide a longitudinal interface therebetween relative to a length of the first and replacement prosthetic heart valves.
Description
    BACKGROUND
  • [0001]
    The present invention relates to prosthetic heart valves. More particularly, it relates to a device and method for functionally replacing a deficient, previously implanted prosthetic heart valve.
  • [0002]
    Implantable heart valve prostheses have long been used to replace various diseased or damaged natural aortic valves, mitral valves, pulmonic valves, and tricuspid valves of the heart. The actual shape and configuration of any particular prosthetic heart valve is, of course, dependent upon the valve being replaced. Generally, the known heart valve prostheses are either bioprostheses or mechanical heart valve prostheses.
  • [0003]
    The bioprostheses or “tissue valves” are generally made of a suitable animal tissue or materials (e.g., harvested porcine valve leaflets, bovine or equine pericardial leaflets, synthetic material leaflets, etc.) that may be mounted onto a stationary metal or plastic frame, referred to as a “stent”. Regardless of whether a stent is provided, bioprosthetic/synthetic heart valves are generally tubular (i.e., when the leaflets are “open”, an internal passage is defined through which fluid (e.g., blood) can flow), and include a sewing or suture ring.
  • [0004]
    The sewing or suture ring provides a means for fixing the prosthetic heart valve to the patient's native heart valve orifice tissue (e.g., native annulus or valvular rim) associated with the native heart valve being repaired or replaced. In particular, an exacting surgical implantation technique is traditionally employed whereby the heart is stopped (cardiopulmonary bypass) and opened followed by surgical removal of damaged or diseased natural valve structure. Subsequently, the prosthetic heart valve is properly oriented within the native valvular area, with the sewing ring being seated against or at the native annulus or valvular rim. Sutures are then used to affix the sewing ring to the natural tissue.
  • [0005]
    A successfully implanted prosthetic heart valve will normally function without problem for many years. In certain instances, however, deficiencies may become evident shortly after implant or within a few years (especially in younger patients). Common functional deficiencies relate to calcification of the prosthetic heart valve leaflets, stenosis, and prosthetic heart valve insufficiency.
  • [0006]
    Under these and other circumstances, the prosthetic heart valve does not function properly, or no longer functions properly, and conventionally is surgically removed and replaced. Removal of a previously implanted prosthetic heart valve entails the same surgical intervention described above, coupled with the need to implant a new prosthetic heart valve. As a point of reference, while well-accepted, the conventional surgical intervention described above is difficult to perform and can result in patient injury or more severe complications. In fact, due to physical weakness, implantation of a prosthetic heart valve via the conventional surgical technique may be considered either too high risk or contra-indicated for certain patients. Further, removal of a previously implanted prosthetic heart valve requires cutting of the sutures that otherwise secure the prosthesis to the native annulus/valvular rim, and re-stitching of a new sewing ring. These activities can further compromise the integrity of the valvular rim and lead to recovery complications, morbidity and mortality.
  • [0007]
    Though unrelated to the specifically addressing prosthetic heart valve replacement concerns, efforts have been made to devise a prosthetic heart valve capable of being delivered percutaneously via transcatheter implantation thus avoiding the complications associated with conventional surgical intervention. For example, Andersen et al., U.S. Pat. No. 6,168,614, the teachings of which are incorporated herein by reference, describes a heart valve prosthesis for implantation in the body by use of a catheter. The valve prosthesis consists of a support structure with a tissue valve connected to it, whereby the support structure is delivered in a collapsed state through a blood vessel and secured to a desired valve location with the support structure in an expanded state. Other percutaneously-delivered prosthetic heart valves have been suggested having a generally similar configuration, such as by Bonhoeffer, P. et al., “Transcatheter Implantation of a Bovine Valve in Pulmonary Position.” Circulation, 2002; 102:813-816 and Cribier, A. et al. “Percutaneous Transcatheter Implantation of an Aortic Valve Prosthesis for Calcific Aortic Stenosis.” Circulation, 2002; 106:3006-3008, the teachings of which are incorporated herein by reference. These techniques appear to rely upon a frictional engagement between the expanded support structure and the native tissue to maintain a position of the delivered prosthesis. That is to say, with the transcatheter technique, conventional sewing of the prosthetic heart valve to the patient's native tissue cannot be performed. Similarly, Bonhoeffer, P. et al., “Percutaneous Insertion of the Pulmonary Valve.” J Am Coll Cardiol, 2002; 39:1664-1669, the teachings of which are incorporated herein by reference, describe percutaneous delivery of a biological valve, sutured to an expandable stent, within a previously implanted valved or non-valved conduit, or a previously implanted valve. Again, it appears that radial expansion of the secondary valve stent is the sole means for placing and maintaining the replacement valve.
  • [0008]
    Prosthetic heart valves continue to be essential tools in the treatment of patient's suffering from cardiac deficiencies. Further, the investigation into percutaneously-delivered prosthetic heart valves appears promising. Unfortunately, the inability to rigidly affix a percutaneous prosthetic heart valve remains problematic. Therefore, a need exists for a prosthetic heart valve and related method of implant that is conducive to percutaneous delivery for replacing a deficient, previously implanted prosthetic heart valve.
  • SUMMARY
  • [0009]
    One aspect of the present invention relates to a method of functionally replacing a previously implanted prosthetic heart valve. The method includes positioning a replacement prosthetic heart valve within an internal region defined by the previously implanted prosthetic heart valve. The replacement prosthetic heart valve is then physically docked to the previously implanted prosthetic heart valve. With this technique, the previously implanted prosthetic heart valve serves as a platform for securement of the replacement prosthetic heart valve to the patient's native tissue.
  • [0010]
    Another aspect of the present invention relates to a prosthetic heart valve for functionally replacing a previously implanted prosthetic heart valve. The prosthetic heart valve includes a support structure, leaflets, and coupling means. The leaflets are mounted to the support structure. The coupling means is associated with the support structure and is adapted to physically dock the prosthetic heart valve to a previously implanted prosthetic heart valve.
  • [0011]
    Another aspect of the present invention relates to a prosthetic heart valve comprising a support structure, leaflets, and connection means. The leaflets are mounted to the support structure. The connection means is associated with the support structure and is adapted to effectuate physical docking of a replacement prosthetic heart valve to the prosthetic heart valve.
  • [0012]
    Another aspect of the present invention relates to a prosthetic heart valve system comprising a first prosthetic heart valve and a replacement heart valve. The first prosthetic heart valve is configured for initial implantation to native heart tissue and includes a support structure, leaflets, and connection means. The leaflets are mounted to the support structure and the connection means is associated with the support structure. The replacement prosthetic heart valve includes a support structure, leaflets, and coupling means. The leaflets are mounted to the support structure and the coupling means is associated with the support structure. With this in mind, the connection means and the coupling means are configured such that the coupling means engages the connection means to physically dock the replacement prosthetic heart valve to the first prosthetic heart valve following implantation of the first prosthetic heart valve.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0013]
    FIG. 1A is a side, perspective view of a prosthetic heart valve in accordance with the present invention;
  • [0014]
    FIG. 1B is a side view of the prosthetic heart valve of FIG. 1A, with portions removed to better illustrate interior leaflets;
  • [0015]
    FIG. 1C is an end view of the prosthetic heart valve of FIG. 1A;
  • [0016]
    FIGS. 2A-2C illustrate percutaneous deployment of the prosthetic heart valve of FIG. 1A within a previously implanted prosthetic heart valve;
  • [0017]
    FIG. 3 is a side perspective view of an alternative embodiment prosthetic heart valve in accordance with the present invention physically docked or connected to a previously implanted prosthetic heart valve;
  • [0018]
    FIG. 4A is a side view of an alternative embodiment prosthetic heart valve in accordance with the present invention;
  • [0019]
    FIG. 4B is a side view of the prosthetic heart valve of FIG. 4A mounted to a previously implanted prosthetic heart valve;
  • [0020]
    FIG. 5 is a side, cross-sectional view of an alternative embodiment prosthetic heart valve physically connected or docked to a previously implanted prosthetic heart valve;
  • [0021]
    FIG. 6A is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention;
  • [0022]
    FIG. 6B is a side view of a replacement prosthetic heart valve physically docked or connected to the prosthetic heart valve of FIG. 6A;
  • [0023]
    FIG. 7 is a side view of an alternative embodiment prosthetic heart valve;
  • [0024]
    FIG. 8 is a side view of an alternative embodiment pros ethic heart valve;
  • [0025]
    FIG. 9A is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention;
  • [0026]
    FIG. 9B is a side view of a replacement prosthetic heart valve physically docking or connecting to the prosthetic heart valve of FIG. 9A;
  • [0027]
    FIG. 10A is a side, perspective view of a prosthetic heart valve adapted to couple with a replacement prosthetic heart valve in accordance with the present invention; and
  • [0028]
    FIG. 10B is a side view of a replacement prosthetic heart valve physically docked or connected to the prosthetic heart valve of FIG. 10A.
  • DETAILED DESCRIPTION
  • [0029]
    One embodiment of a prosthetic heart valve 10 in accordance with the present invention is shown in FIG. 1A. The prosthetic heart valve 10 includes a support structure 12, leaflets 14, and coupling means 16 (referenced generally in FIG. 1A). Details on the various components are described below. In general terms, however, the support structure 12 is generally tubular, with the leaflets 14 being secured to an interior of the support structure 12. The coupling means 16 extends radially outwardly relative to the leaflets 14. As described below, the coupling means 16 is adapted to physically dock or connect the prosthetic heart valve 10 to a previously implanted prosthetic heart valve (not shown) to achieve a connective interface between the physical structures of the prosthetic heart valve 10 and the previously implanted prosthetic heart valve apart from and in addition to any interface that may be effectuated by radial press-fitting of the prosthetic heart valve 10 against the previously implanted prosthetic heart valve. As used throughout this specification, the term “prosthetic heart valve” is in reference to a bioprosthetic heart valve or a heart valve configuration utilizing synthetic leaflets, and excludes mechanical heart valves characterized as having a mechanically coupled, metal occluding disk or leaflet structure.
  • [0030]
    The support structure 12 is, in one embodiment, a wire stent capable of transitioning from a collapsed state to an expanded state (shown in FIG. 1A). In one embodiment, individual wires 20 comprising the support structure 12 are formed of a metal or other material that facilitates folding of the support structure 12 to a contracted state in which an internal diameter defined by the support structure 12 is greatly reduced from an internal diameter in the expanded state. Thus, for example, in the collapsed state, the support structure 12 can be mounted over a delivery device, such as a balloon catheter, as described below. Alternatively, the wires 20 can be formed from a shape memory material such as a nickel titanium alloy (NiTi or Nitinol®). With this configuration, the support structure 12 is self-transitionable from the contracted state to the expanded state, such as by the application of heat, energy, etc.
  • [0031]
    As described in greater detail below, the prosthetic heart valve 10 is, following an implantation procedure, physically docked to a previously implanted prosthetic heart valve (not shown). With this in mind, a longitudinal length and diameter of the support structure 12 in the expanded state is related to the previously implanted prosthetic heart valve to which the prosthetic heart valve 10 is applied. Thus, the support structure 12 can assume a variety of different longitudinal lengths and/or diameters. In one embodiment, for example, the support structure 12 has a longitudinal length in the expanded state that is slightly greater than a length of the previously implanted prosthetic heart valve, and a free-standing outer diameter that is greater than an inner diameter of the previously implanted prosthetic heart valve. With this one embodiment, upon transitioning toward the expanded state, the support structure 12 presses against an inner diameter of the previously implanted prosthetic heart valve. With the one embodiment of FIG. 1A, the support structure 12 defines a right cylinder in the expanded state. However, as described in greater detail below, other shapes are equally acceptable. For example, portions of the support structure 12 can define an enlarged diameter as compared to other portions. Further, depending upon the previously implanted heart valve being functionally replaced, the support structure 12 can be less uniform along a longitudinal length thereof, such as when functionally replacing a Freestyle™ bioprosthetic tissue valve available from Medtronic, Inc., or similar prosthetic heart valve whereby the support structure 12 wall can be cut away.
  • [0032]
    The leaflets 14 are secured to an interior of the support structure 12. FIG. 1B better illustrate this relationship, whereby portions of the wires 20 are removed from the drawing. The leaflets 14 can be formed from a variety of materials, such as autologous tissue, xenograph material, or synthetics as are known in the art. With the embodiment of FIGS. 1A and 1B, the leaflets 14 are provided as a homogenous, biological valve structure, such as a porcine, bovine, or equine valve. Alternatively, the leaflets 14 can be provided independent of one another (e.g., bovine or equine pericardial leaflets) and subsequently assembled to the support structure 12. Further, while three of the leaflets 14 are illustrated in FIGS. 1A and 1B, the prosthetic heart valve 10 of the present invention can incorporate more or fewer leaflets than three.
  • [0033]
    In more general terms, the combination support structure 12/leaflets 14 can assume a variety of other configurations varying from that shown and described, including any known prosthetic heart valve design. In one embodiment, the support structure 12/leaflets 14 is any known expandable prosthetic heart valve configuration, whether balloon expandable, self-expanding, or unfurling (as described, for example, in U.S. Pat. Nos. 3,671,979; 4,056,854; 4,994,077; 5,332,402; 5,370,685; 5,397,351; 5,554,185; 5,855,601; and 6,168,614; U.S. patent application Publication No. 2004/0034411; Bonhoeffer P., et al., “Percutaneous Insertion of the Pulmonary Valve”, Pediatric Cardiology, 2002; 39:1664-1669; Anderson H R, et al., “Transluminal Implantation of Artificial Heart Valves”, EUR Heart J., 1992; 13:704-708; Anderson, J. R., et al., “Transluminal Catheter Implantation of New Expandable Artificial Cardiac Valve”, EUR Heart J., 1990, 11: (Suppl) 224a; Hilbert S. L., “Evaluation of Explanted Polyurethane Trileaflet Cardiac Valve Prosthesis”, J Thorac Cardiovascular Surgery, 1989; 94:419-29; Block P C, “Clinical and Hemodyamic Follow-Up After Percutaneous Aortic Valvuloplasty in the Elderly”, The American Journal of Cardiology, Vol. 62, Oct. 1, 1998; Boudjemline, Y., “Steps Toward Percutaneous Aortic Valve Replacement”, Circulation, 2002; 105:775-558; Bonhoeffer, P., “Transcatheter Implantation of a Bovine Valve in Pulmonary Position, a Lamb Study”, Circulation, 2000:102:813-816; Boudjemline, Y., “Percutaneous Implantation of a Valve in the Descending Aorta In Lambs”, EUR Heart J, 2002; 23:1045-1049; Kulkinski, D., “Future Horizons in Surgical Aortic Valve Replacement: Lessons Learned During the Early Stages of Developing a Transluminal Implantation Technique”, ASAIO J, 2004; 50:364-68; the teachings of all of which are incorporated herein by reference. Thus, the support structure 12 can include other features, not specifically described or shown, apart from the coupling means 16. In an alternative embodiment, the support structure 12 has a non-expandable design, but is sized and shaped to nest within a previously implanted heart valve (not shown) in a manner that presses features of the previously implanted heart valve (e.g., leaflets) outwardly relative to the native conduit.
  • [0034]
    Regardless of the exact configuration of the support structure 12 and leaflets 14, the coupling means 16 is connected to, or formed as part of, the support structure 12 and, in one embodiment, includes an inflow section 30 and an outflow section 32. With the one embodiment of FIG. 1A, the inflow section 30 consists of a plurality of discrete anchors 34 formed as extensions of individual ones of the wires 20 otherwise comprising the support structure 12. Alternatively, the anchors 34 can be separately formed and attached to the support structure 12. As described in greater detail below, the inflow anchors 34 are configured to engage a sewing ring (not shown) of a previously implanted prosthetic heart valve (not shown). Alternatively, the inflow anchors 34 can be configured to engage other structure(s) of the previously implanted prosthetic heart valve. With this in mind, in one embodiment each of the inflow anchors 34 has a hook-like shape and terminates in a barbed end 36. The curvature associated with each of the inflow anchors 34 is such that the respective barbed ends 36 extend inwardly relative to an inflow end 38 of the support structure 12.
  • [0035]
    The outflow section 32 similarly includes, with the one embodiment of FIG. 1A, a plurality of outflow anchors 40 each in the form of a hook terminating in a barbed end 42. As described in greater detail below, each of the outflow anchors 40 are adapted to project around the stent structure (not shown) associated with a previously implanted prosthetic heart valve (not shown), with the respective barbed ends 42 engaging within material associated with that stent structure. Thus, with the one embodiment of FIG. 1A, the radius of curvature associated with the outflow anchors 40 is less than a radius of curvature associated with the inflow anchors 34. Alternatively, the anchors 40 can be configured the physically dock with other structure(s) provided by the previously implanted heart valve.
  • [0036]
    Any number of the inflow anchors 34 and/or the outflow anchors 40 can be provided with the prosthetic heart valve 10 of the present invention, and preferably correlates with the previously implanted prosthetic heart valve. Further, the anchors 34, 40 can assume a variety of forms that are or are not identical, such as barbs, clips, staples, hooks, etc. Also, while the anchors 34, 40 are illustrated as extending from opposing ends, respectively, of the support structure 12, alternatively, the anchors 34 and/or 40 can be intermediately disposed along a longitudinal length of the support structure 12.
  • [0037]
    With additional reference to FIG. 1C, the prosthetic heart valve 10 is constructed by securing the leaflets 14 to an interior periphery of the support structure 12. To this end, a wide variety of attachment techniques can be employed. For example, the leaflets 14 can be sewn to the support structure 12. Alternatively, other coupling techniques, such as crimping, adhesive, etc., can be employed. The coupling means 16 are similarly secured to the support structure 12 extending radially outwardly relative to the leaflets 14. As a point of reference, FIG. 1C illustrates the outflow section 32 of the coupling means 16. Regardless, the coupling means 16 or portions thereof, can be integrally or homogenously formed with the support structure 12. Alternatively, the coupling means 16, or portions thereof, can be separately formed and assembled to the support structure 12. In one embodiment, construction and/or attachment of the coupling means 16 is such that in the expanded state of the support structure 12 (FIGS. 1A-1C), the coupling means extends radially outwardly, whereas in the contracted state (not shown), the coupling means 16 is retracted.
  • [0038]
    The prosthetic heart valve 10 of the present invention is uniquely adapted to facilitate an implantation technique whereby the prosthetic heart valve 10 is mounted to a previously implanted prosthetic heart valve. By way of reference, FIG. 2A illustrates, in simplified form, a native heart valve 50 of a patient to which a previously implanted prosthetic heart valve 52 has been secured. The native heart valve 50 can be any of the human heart valves (i.e., mitral valve, tricuspid valve, aortic valve, or pulmonary valve), it being understood that the type and orientation of the previously implanted prosthetic heart valve 52 will correspond with the particular form, shape, and function of the native heart valve 50. Regardless, the native heart valve 50 defines a valve annulus or valvular rim 54 from which a lumen 56 defined by the native heart valve 50 extends.
  • [0039]
    The previously implanted prosthetic heart valve 52 is, in one embodiment, any known prosthetic heart valve or valved conduit, and thus can assume a variety of forms. In most general terms, the previously implanted prosthetic heart valve 52 includes a valve structure 60 connected to a sewing ring 62. The valve structure 60 may or may not include an internal stent, but is generally tubular in form, defining an internal region 64 (referenced generally) extended from an inflow end 66 to an outflow end 68. With the exemplary embodiment of FIG. 2A, the previously implanted prosthetic heart valve 52 includes stent posts 69 (for example, a biological, aortic or mitral prosthetic heart valve including a stent with three commissure posts), it being understood that the prosthetic heart valve of the present invention can be employed to functionally replace stentless prosthetic heart valves as well. Relative to the view of FIG. 2A, the internal region 62 is essentially encompassed by the valve structure 60, it being understood that the valve structure 60 selectively allows for fluid flow into or out of the lumen 56 of the natural heart valve 50; thus, the internal region 64 is openable to the lumen 56. For ease of illustration, leaflets associated with the previously implanted prosthetic heart valve 52 are not shown in FIG. 2A. Regardless, the previously implanted prosthetic heart valve 52 has been implanted via accepted surgical techniques, whereby the sewing ring 62 is sewn or attached to the annulus 54 of the native heart valve 50.
  • [0040]
    At some time following implant, it may be discovered that the previously implanted prosthetic heart valve 52 is functionally deficient due to one or more of a variety of factors, such as stenosis, valve failure, inflammation, native valve insufficiency, etc. Regardless, rather than removing the previously implanted prosthetic heart valve 52 and implanting a second, similarly formed prosthetic heart valve via rigorous open heart surgical techniques, the method of the present invention leaves the previously implanted prosthetic heart valve 52 in place, and deploys the prosthetic heart valve 10 (FIG. 1A) onto the previously implanted prosthetic heart valve 52.
  • [0041]
    In one embodiment, the prosthetic heart valve 10 is delivered to the native heart valve 52 percutaneously, as represented in simplified form in FIG. 2B. In general terms, a transcatheter assembly 70 is provided, including a delivery catheter 72, a balloon catheter 74, and a guide wire 76. The delivery catheter 72 is of a type known in the art, and defines a lumen 78 within which the balloon catheter 74 is received. The balloon catheter 74, in turn, defines a lumen (not shown) within which the guide wire 76 is slidably disposed. Further, the balloon catheter 74 includes a balloon 80 that is fluidly connected to an inflation source (not shown). The transcatheter assembly 70 is appropriately sized for a desired percutaneous approach to the native heart valve 50. For example, the transcatheter assembly 70 can be sized for delivery to the native heart valve 50 via an opening at a carotid artery, a jugular vein, a sub-clavian vein, femoral artery or vein, etc. Essentially, any percutaneous intercostals penetration can be made to facilitate use of the transcatheter assembly 70.
  • [0042]
    With the above in mind, prior to delivery, the prosthetic heart valve 10 is mounted over the balloon 80 in a contracted state as shown in FIG. 2B. As compared to the expanded state of FIG. 1A, the support structure 12 is compressed onto itself and the balloon 80, thus defining a decreased inner diameter (as compared to an inner diameter in the expanded state). Further, the coupling means 16, including the inflow and outflow anchors 34, 40, are retracted in the contracted state (as compared to an extended orientation of the coupling means 16 in the expanded state of FIG. 1A).
  • [0043]
    With the prosthetic heart valve 10 mounted to the balloon 80, the transcatheter assembly 70 is delivered through a percutaneous opening (not shown) in the patient via the delivery catheter 72. The native heart valve 50 is located by extending the guide wire 76 from a distal end 82 of the delivery catheter 72, with the balloon catheter 74 otherwise retracted within the delivery catheter 72. In this regard, the guide wire 76 passes through the internal region 64 defined by the previously implanted prosthetic heart valve 52.
  • [0044]
    Once the native heart valve 50 has been located, the balloon catheter 74 is advanced distally from the delivery catheter 72 along the guide wire 76, with the balloon 80/prosthetic heart valve 10 positioned relative to the previously implanted heart valve 52 as shown in FIG. 2B. More particularly, the balloon 80/prosthetic heart valve 10 is positioned within the internal region 64 of the previously implanted prosthetic heart valve 52, with the inflow anchors 34 positioned adjacent the inflow end 66/sewing ring 62 of the previously implanted prosthetic heart valve 52, whereas the outflow anchors 40 are positioned adjacent the outflow end 68 of the previously implanted prosthetic heart valve 52. In an alternative embodiment, the prosthetic heart valve 10 is delivered to the previously implanted prosthetic heart valve 52 via a minimally invasive surgical incision (non-percutaneously). In another alternative embodiment, the prosthetic heart valve 10 is delivered via open heart/chest surgery. Regardless, with the prosthetic heart valve 10 in the contracted state, the support structure 12 readily moves within the internal region 64 of the previously implanted prosthetic heart valve 52, and the coupling means 16, which is otherwise retracted, does not unintentionally contact or engage portions of the previously implanted prosthetic heart valve 52. In one embodiment, the prosthetic heart valve 10 includes a radiopaque material to facilitate visual confirmation of proper placement of the prosthetic heart valve 10 relative to the previously implanted prosthetic heart valve 52. Alternatively, other known surgical visual aids can be incorporated into the prosthetic heart valve 10.
  • [0045]
    Once the prosthetic heart valve 10 is properly positioned, the balloon catheter 74 is operated to inflate the balloon 80, thus transitioning the prosthetic heart valve 10 to the expanded state as shown in FIG. 2C. As a point of reference, the transcatheter assembly 70 is removed from the view of FIG. 2C. Alternatively, where the support structure 12 is formed of a shape memory material, the prosthetic heart valve 10 self-transitions to the expanded state of FIG. 2C (and thus can be percutaneously delivered by an appropriate catheter device other than a balloon catheter). Similarly, with an alternative configuration, the prosthetic heart valve 10 can be unfurled to the expanded state, again without the assistance of a balloon catheter. Regardless, the support structure 12 expands within the internal region 64 of the previously implanted heart valve 52, radially pressing against the valve structure 60. To this end, where the previously implanted prosthetic heart valve 52 includes leaflets (not shown), radial expansion of the support structure 12 presses against these leaflets, lodging them against the valve structure 60.
  • [0046]
    With the prosthetic heart valve 10 in the expanded state, the coupling means 16 physically docks or connects the prosthetic heart valve 10 to the previously implanted prosthetic heart valve 52. For example, as shown in FIG. 2C, the inflow anchors 34 lodge within the sewing ring 62 of the previously implanted prosthetic heart valve 52, such as via the barbed end 36 (FIG. 1A) associated with each of the inflow anchors 34. The outflow anchors 40 wrap around the outflow end 68 of the previously implanted prosthetic heart valve 52, with the corresponding barbed ends 42 lodging within an outer fabric therein. For example, each of the outflow anchors 40 wraps about a corresponding stent post 69 of the previously implanted prosthetic heart valve 52. Notably, the physical docking or connection between the coupling means 16 and the previously implanted heart valve 52 is apart from, or in addition to, any frictional, radial interface between the prosthetic heart valve 10 and the previously implanted heart valve 52 otherwise achieved by radial force or pressure exerted by the support structure 12 against the previously implanted heart valve 52 in the expanded state.
  • [0047]
    With the above-described technique, the prosthetic heart valve 10 serves as a functional replacement for the previously implanted prosthetic heart valve 52, utilizing the sewing ring 62 of the previously implanted prosthetic heart valve 52 as a platform for securement relative to the native heart valve 50. That is to say the sewing ring 62 of the previously implanted heart valve 52 has previously been sutured to the annulus or valvular rim 56 of the native heart valve 50; by fastening the prosthetic heart valve 10 to the sewing ring 62, no additional suturing is required. Following fastening of the prosthetic heart valve 10 to the previously implanted prosthetic heart valve 52, the leaflets 14 (one of which is shown in FIG. 2C) serve as replacement valve leaflets, facilitating normal functioning of the native heart valve 50.
  • [0048]
    Attachment of the prosthetic heart valve 10 to the previously implanted prosthetic heart valve 52 can be accomplished in a variety of fashions other than that described with respect to the one embodiment of prosthetic heart valve 10 described above. For example, the coupling means 16 need not include inflow and outflow sections, but instead can be directly, physically docked to the previously implanted prosthetic heart valve 52 at only one end thereof. Further, while the coupling means 16 has been described as including hooks with barbed ends, other anchoring techniques can be employed whereby the anchors do not necessarily pierce through the previously implanted prosthetic heart valve 52 material. To this end, clip(s), staple(s), or other fastening devices can be employed.
  • [0049]
    For example, an alternative embodiment prosthetic heart valve 80 internally positioned and physically docked or connected to a previously implanted prosthetic heart valve 52 is shown in FIG. 3. The prosthetic heart valve 80 includes a support structure 82, leaflets (not shown) and coupling means 84 (referenced generally). In general terms, the support structure 82 and the leaflets can assume any of the forms previously described with respect to the prosthetic heart valve 10. (FIGS. 1A-1C) previously described. With the embodiment of FIG. 3, the coupling means 84 includes an outflow anchor 86, intermediate anchors 88 a, 88 b, and inflow anchors 90. As described below, each of the anchors 86-90 can achieve physical docking or connection of the prosthetic heart valve 80 to the previously implanted heart valve 52, such that one or more of the features 86-90 can be eliminated. Alternatively, or in addition, the coupling means 84 can include components not specifically shown in FIG. 3.
  • [0050]
    In one embodiment, the outflow anchor 86 is a clasp or hook formed as part of the support structure 82 at the outflow end thereof. For example, the support structure 82 can be a wire-formed stent, with an individual wire being bent, or two wires combined, to form the outflow anchor 86. The outflow anchor 86 is generally sized and shaped in accordance with an expected size and shape of a stent post 69 of the previously implanted prosthetic heart valve 52 for reasons described below. To this end, the outflow anchor 86 can be the result of normal manufacture techniques for forming a stent-type support structure. During implantation, the prosthetic heart valve 80 is positioned, in a contracted state, within the previously implanted prosthetic heart valve 52 with the outflow anchor 86 located beyond the previously implanted prosthetic heart valve 52, and in particular the stent posts 69. The prosthetic heart valve 80 is then transitioned to an expanded state (shown in FIG. 3). Once expanded, the prosthetic heart valve 80 is retracted relative to the previously implanted prosthetic heart valve 52 such that the outflow anchor 86 slides over one of the stent posts 69, thereby physically docking or connecting the prosthetic heart valve 80 to the previously implanted prosthetic heart valve 52. In one embodiment, the outflow anchor 86 is sized and shaped so as to readily clear a leading end of the stent post 69, but will more firmly dock or connect to the stent post 69 at an intermediate section thereof that is otherwise wider and/or thicker than the leading end. Where the previously implanted prosthetic heart valve 52 includes an internal wire frame (not shown) traversing an outflow periphery thereof (e.g., Carpentier-Edwards Bioprostheses, available from Edwards Lifescience), a more rigid physical docking or connection can be achieved. While the prosthetic hart valve 80 is illustrated in FIG. 3 as including a single outflow anchor 86, alternatively two or more of the outflow anchors 86 can be provided.
  • [0051]
    The intermediate anchors 88 a, 88 b are, in one embodiment, hooks or barbs, and extended generally radially outwardly from the support structure 82 at a location(s) between the opposing ends thereof. To this end, the intermediate anchors 88 a, 88 b are located to physically dock or connect to portions of the previously implanted prosthetic heart valve 52 at points other than leading ends of the stent posts 69. For example, the intermediate anchor 88 a is configured and positioned to pierce into material of the previously implanted prosthetic heart valve 52 (such as between adjacent stent posts 69 and/or along a length of one of the stent posts 69) upon transitioning of the prosthetic heart valve 80 to the expanded state. In one embodiment, the intermediate anchor 88 a pierces through an interior of the previously implanted prosthetic heart valve 52. The intermediate anchor 88 b, on the other hand, is configured and positioned to wrap about and contact an area of the previously implanted prosthetic heart valve 52 between adjacent ones of the stent posts 69 with the prosthetic heart valve 80 in the expanded state.
  • [0052]
    Where the previously implanted prosthetic heart valve 52 includes an internal wire frame (not shown) traversing an outflow periphery thereof (e.g., Carpentier-Edwards Bioprostheses, available from Edwards Lifescience), a more rigid physical docking or connection can be achieved. For example, the intermediate anchor 88 a extends immediately below (relative to the orientation of FIG. 3), and thus braces against the internal wire frame. Additionally, the intermediate anchor 88 b extends immediately above (relative to the orientation of FIG. 3), and thus braces against, the internal wire frame. In alternative embodiments, more or less of the intermediate anchors 88 a, 88 b can be provided as compared to the one embodiment illustrated in FIG. 3.
  • [0053]
    In one embodiment, the inflow anchors 90 are hooks or barbs extending from the support structure 82, although a variety of other constructions are also acceptable. Regardless, the inflow anchors 90 are constructed to facilitate physical docking or connection to the sewing ring 62 of the previously implanted prosthetic heart valve 52.
  • [0054]
    In addition or as an alternative to the coupling means described above, the support structure of the prosthetic heart valve can, in and of itself, be adapted to facilitate physical docking or connection to the previously implanted prosthetic heart valve 52. For example, an alternative embodiment prosthetic heart valve 100 in accordance with the present invention is shown in FIG. 4A. The prosthetic heart valve 100 is similar to the prosthetic heart valve 10 (FIG. 1A) previously described, and is adapted to functionally replace a previously implanted prosthetic heart valve (not shown). With this in mind, the prosthetic heart valve 100 includes a support structure 102, leaflets (not shown), and coupling means 104. With the one embodiment of FIG. 4A, the support structure 102 is a tubular, wire stent and defines, in the expanded state of FIG. 4A, opposing first and second end portions 106, 108 and an intermediate portion 110. The leaflets are similar to the leaflets 14 (FIG. 1A) previously described and are interiorly secured to the support structure 102 along the intermediate portion 110. As made clear below, the first and second end portions 106, 108 serve as the coupling means 104.
  • [0055]
    In particular, the support structure 102 is constructed such that in the expanded state of FIG. 4A, the first and second end portions 106, 108 define an increased outer diameter as compared to the intermediate portion 110. For example, the first end portion 106 increases in diameter from the intermediate portion 110 to a first end 112. Similarly, the second end portion 108 increases in diameter from the intermediate portion 110 to a second end 114. Alternatively, other shapes can be defined, and only one of the first or second end portions 106, 108 need define the increased diameter in the expanded state. Regardless, a maximum diameter defined by one or both of the first and second end portions 106, 108 corresponds with a diameter of a previously implanted prosthetic heart valve (not shown in FIG. 4A), with the maximum diameter being greater than a diameter of the previously implanted prosthetic heart valve. The support structure 102 need not assume the hourglass-like shape of FIG. 4A in a contracted state (not shown), but instead can be a substantially right cylinder amenable for delivery to a target site. Transition to the expanded state can be achieved in a variety of fashions, such as by an appropriately devised balloon catheter (e.g., a balloon catheter having three balloon sections inflatable to different outer diameters), or by employing a shape memory material for the support structure 102.
  • [0056]
    Regardless of exact construction, the prosthetic heart valve 100 is delivered in the contracted state, according to the techniques previously described. In particular, and with reference to FIG. 4B, the prosthetic heart valve 100 is positioned within the internal region 64 of the previously implanted prosthetic heart valve 52 (it being understood that in the view of FIG. 4B, the prosthetic heart valve 100 has been transitioned to the expanded state). Once properly positioned, the prosthetic heart valve 100 is transitioned to the expanded state, with the first and second end portions 106, 108 assuming the increased outer diameter as compared to the intermediate section 110. Once again, the support structure 102 presses against the previously implanted prosthetic heart valve 52 that is otherwise secured to the native heart valve 50 (FIG. 2A). Once in the expanded state, the coupling means 104 (i.e., the first and second end portions 106, 108) nest about the previously implanted prosthetic heart valve 52, thereby physically docking or connecting the prosthetic heart valve 100 to the previously implanted prosthetic heart valve 52. Notably, the coupling means 104 associated with FIGS. 4A and 4B can be used alone or in conjunction with the coupling means 16 (FIG. 1A) previously described.
  • [0057]
    Regardless of exact form, the coupling means associated with the prosthetic heart valve of the present invention need not effectuate a rigid, locking engagement with the previously implanted prosthetic heart valve 52. In fact, depending upon the exact form of the previously implanted prosthetic heart valve, effectuating a rigid engagement may be difficult. In more general terms, however, the coupling means associated with the prosthetic heart valve of the present invention is capable of remaining physically docked or connected to the previously implanted prosthetic heart valve 52 under backpressure conditions of at least 200 mHg.
  • [0058]
    To ensure a sealing relationship between the prosthetic heart valve 10, 100, and the previously implanted prosthetic heart valve 52, in an alternative embodiment, a gasket material can be provided as shown, for example, at 130 in FIG. 5. As a point of reference, FIG. 5 depicts the previously implanted prosthetic heart valve 52 in conjunction with an alternative embodiment prosthetic heart valve 10′ that is highly similar to the prosthetic heart valve 10 (FIG. 1A) previously described and further includes the gasket material 130. The gasket material 130 is, in one embodiment, attached to an outer circumference of the support structure 12 at or adjacent an annulus portion 132 that is otherwise expected to be positioned adjacent the annulus or valvular rim 54 of the previously implanted prosthetic heart valve 52. Alternatively, the gasket material 130 can encompass a more significant exterior length of the support structure 12. Regardless, the gasket material 130 can be made from fabric, felt, Teflon®, silicone, pericardium, or other polymeric or biological materials. As shown in FIG. 5, the gasket material 130 serves as a filler to prevent holes from forming between the prosthetic heart valve 10′ and the previously implanted prosthetic heart valve 52 adjacent the annulus or valvular rim 54, thus preventing leaching of blood back through this region.
  • [0059]
    In addition to, in one embodiment, providing the prosthetic heart valve 10 (FIG. 1A) with coupling means adapted to achieve physical docking or connection with a previously implanted prosthetic heart valve, in other embodiments, the present invention includes providing the previously implanted prosthetic heart valve with features that further facilitate the desired physical docking or connection. In this context, it is possible to reference the initial, first implanted prosthetic heart valve as a “first implanted prosthetic heart valve” and the subsequently implanted, functional replacement prosthetic heart valve (e.g., the prosthetic heart valve 10 of FIG. 1A) as a “replacement prosthetic heart valve”. With these definitions in mind, FIG. 6A illustrates one embodiment of a first implanted prosthetic heart valve 200 in accordance with the present invention. The first implanted prosthetic heart valve 200 can assume a variety of forms, but generally includes a support structure 202, leaflets (not shown), and connection means 206. The support structure 202 maintains the leaflets and facilitates attachment of the prosthetic valve 200 to a native heart valve (not shown). The connection means 206 is connected to, or formed by, the support structure 202, and promotes physical docking or connection of a replacement prosthetic heart valve (not shown, but for example, the prosthetic heart valve 10 of FIG. 1A) to the first prosthetic heart valve 200.
  • [0060]
    In the one embodiment of FIG. 6A , the support structure 202 defines a sewing ring 208 and includes a stent (hidden) forming stent posts 210 and encompassed by a covering 212, such as with a Medtronic® Hancock II® or Musiac® stented tissue valve. A wide variety of other stented tissue valves, such as those described in U.S. Pat. Nos. 4,680,031, 4,892,541, and 5,032,128, the teachings of which are incorporated herein by reference, can be employed as the support structure 202. Alternatively, the support structure 202 can be stentless, such as, for example, with a Freestyle® stentless bioprosthesis, available from Medtronic, Inc. Other acceptable stentless configurations are described in U.S. Pat. Nos. 5,156,621; 5,197,979; 5,336,258; 5,509,930; 6,001,126; 6,254,436; 6,342,070; 6,364,905; and 6,558,417, the teachings of all of which are incorporated herein by reference, to name but a few. Regardless, the leaflets (not shown) are attached to the support structure 202 (e.g., by sewing, crimping, adhesive, etc.), and can assume a variety of forms (autologous tissue, xenograph tissue, or synthetic material).
  • [0061]
    With the general construction of the support structure 202/leaflets in mind, the connection means 206 associated with the embodiment of FIG. 6A includes a wire ring 214 extending between the stent posts 210 (either adjacent the leading (or outflow) ends thereof as illustrated, or more closely positioned to the sewing ring 208). The wire ring 214 can be fastened to the support structure 202 in a variety of manners, including, for example, sewing the wire ring 214 to the fabric covering 212. While the wire ring 214 is illustrated as being a single, continuous structure, in an alternative embodiment, two or more individual wire segments are provided and secured to the support structure, with the segments combining to define a continuous or discontinuous ring-like structure 202. Regardless, the wire ring 214 is positioned so as to not interfere with functioning/movement of the leaflets adjacent an outflow (or inflow) end of the first prosthetic heart valve 200.
  • [0062]
    With further reference to FIG. 6B, the connection means 206, and in particular the wire ring 214, is adapted to promote physical docking or connecting of a replacement prosthetic heart valve 220 to the first prosthetic heart valve 200. By way of reference, the replacement prosthetic heart valve 220 is akin to the prosthetic heart valve 10 (FIG. 1A) previously described, and includes a support structure 222 and a coupling means in the form of outflow anchors or hooks 224. With this in mind, the first prosthetic heart valve 200 is initially implanted in a patient (not shown) and secured to native tissue (not shown), for example via the sewing ring 208. When desired, the first prosthetic heart valve 200 can be functionally replaced by the replacement prosthetic heart valve 220. More particular, the replacement prosthetic heart valve 220 can be delivered and positioned in a contracted state within the first prosthetic heart valve 220 pursuant to any of the techniques previously described. The replacement prosthetic heart valve 220 then transitions to the expanded state (shown in FIG. 6B), thereby deploying the coupling means or outflow hooks 224. The replacement prosthetic heart valve 220 is then maneuvered such that the hooks 224 engage the wire ring 214, thereby physically docking or connecting the replacement prosthetic heart valve 220 to the first prosthetic heart valve 200. Alternatively, the replacement prosthetic heart valve 220 can include differing coupling means, such as a detent, for capturing or physically connecting to the wire ring 214.
  • [0063]
    The connection means 206 associated with the first prosthetic heart valve 200 can assume a number of other configurations. For example, FIG. 7 illustrates an alternative embodiment first prosthetic heart valve 250 including a support structure 252, leaflets (not shown), and connection means 254 (referenced generally). The support structure 252 and the leaflets can assume any of the forms previously described. The connection means 254 includes a plurality of rings 256, respective ones of which extend from individual stent posts 258. Each of the rings 256 preferably extends in a radially outward fashion relative to the corresponding stent post 258, and is longitudinally open relative to a central axis defined by the support structure 252. Following initial implant, the first prosthetic heart valve 250 can be functionally replaced by a replacement prosthetic heart valve (not shown, but akin to the prosthetic heart valve 10 of FIG. 1A) by physically docking or connecting the coupling means (e.g., hooks) of the replacement prosthetic heart valve within the rings 256.
  • [0064]
    Yet another alternative embodiment first prosthetic heart valve 280 in accordance with the present invention is shown in FIG. 8 and includes a support structure 282, leaflets (not shown) and connection means 284 (referenced generally). The support structure 282 and the leaflets can assume any of the forms previously described. The connection means 284 is attached to, or formed by, the support structure 282 and includes a plurality of protrusions 286. With the one embodiment of FIG. 8, the protrusions 286 are hooks, although other configurations, such as posts, barbs, eyelets, etc., are equally acceptable. Regardless, the protrusions are positioned, in one embodiment, at an inflow side of the prosthetic heart valve 280, and are adapted to facilitate physical docking or connection with a corresponding coupling means or feature (e.g., post, hook, eyelet, etc.) of a replacement prosthetic heart valve (not shown) following a procedure to functionally replace the first prosthetic heart valve 280.
  • [0065]
    Yet another alternative embodiment first prosthetic heart valve 300 in accordance with the present invention is shown in FIG. 9A and includes a support structure 302, leaflets (not shown), and connection means 304 (referenced generally). The support structure 302 and the leaflets can assume any of the forms previously described. The connection means 304 is formed by the support structure 302 and, with the embodiment of FIG. 9A, includes a plurality of apertures 306 (shown generally in FIG. 9A). During a procedure to functionally replace the first prosthetic heart valve 300 with a replacement prosthetic heart valve 310 and as shown in FIG. 9B, the apertures 306 are sized to capture corresponding tabs 312 provided by the replacement prosthetic heat valve 310, thus physically docking or connecting the replacement prosthetic heart valve 310 to the first prosthetic heart valve 300. Further, with the one embodiment of FIG. 9B, additional coupling means 314 (e.g., barbed hooks) are provided with the replacement prosthetic heart valve 310 and also physically dock or connect to the first prosthetic heart valve 300.
  • [0066]
    Yet another alternative embodiment first prosthetic heart valve 330 is shown in FIG. 10A and includes a support structure 332, leaflets (not shown) and connection means 334 (referenced generally). The support structure 332 and the leaflets can assume any of the forms previously described, with the support structure 332 including stent posts 336 and a sewing ring 338. The connection means 334 is connected to, or formed by, the support structure 332 and includes, with the one embodiment of FIG. 10A, a plurality of outflow ribs 340 and an inflow rib 342. Respective ones of the outflow ribs 340 extend radially outwardly relative to respective ones of the stent posts 336 and are positioned along a length thereof, in one embodiment adjacent a leading end of the respective stent post 336. The inflow rib 342 is contiguous with, and extends axially from, the sewing ring 338. The connection means 334 is configured to facilitate physical docking or connection of a replacement prosthetic heart valve, such as the replacement valve 350 as shown in FIG. 10B. In one embodiment, the replacement prosthetic heart valve 350 has coupling means 352 (referenced generally) including tabs 354 and protrusions 356. The tabs 354 define capture slots 358 relative to a support structure 360 of the replacement prosthetic heart valve 350. Following a functional replacement procedure, the outflow ribs 340 are lodged within the capture slots 358 (formed, for example, by corresponding recess and radial extension features), and the protrusions 356 engage the inflow rib 342.
  • [0067]
    The embodiments of FIGS. 6A-10B above are but a few examples of combination first prosthetic heart valve/replacement prosthetic heart valve configurations in accordance with the present invention. In other alternative embodiments, the first prosthetic heart valve includes a magnetic material (such as internal, magnetic ring) whereas the replacement prosthetic heart valve includes a magnetic material connected to or provided as part of its support structure. Virtually any magnetic material could be employed, such as ferrous or ferritic materials, rare earth magnetic materials such as Neodymium (Nd—Fe—B) and Samarium cobalt magnets (SmCo), etc. During use, the replacement prosthetic heart valve is magnetically attracted to the magnetic material of the first prosthetic heart valve, thus facilitating physical docking or connection to the first prosthetic heart valve. In more general terms, the first prosthetic heart valve and the corresponding replacement valve are configured to provide complimentary features that promote physical docking or connection of the replacement prosthetic heart valve to the first prosthetic heart valve as part of a procedure to functionally replace the first prosthetic heart valve. To this end, the complimentary first prosthetic heart valve and replacement prosthetic heart valve can be packaged together and sold as a kit.
  • [0068]
    The prosthetic heart valve and related method of implantation presents a marked improvement over previous designs. In particular, by utilizing a previously implanted prosthetic heart valve as a platform to facilitate mounting relative to a native heart valve, the prosthetic heart valve of the present invention is highly amenable to percutaneous delivery. Further, by functionally replacing a previously implanted prosthetic heart valve, the deficient prosthetic heart valve need not be physically removed from the patient. Thus, the prosthetic heart valve and related method of implantation of the present invention can be used at any point during the “useful life” of a conventional prosthetic heart valve. Further, the methodology associated with the present invention can be repeated multiple times, such that several prosthetic heart valves of the present invention can be mounted on top of or within one another.
  • [0069]
    Although the present invention has been described with reference to preferred embodiments, workers skilled in the art will recognize that changes can be made in form and detail without departing from the spirit and scope of the present invention.
Citations de brevets
Brevet cité Date de dépôt Date de publication Déposant Titre
US334629 *19 janv. 1886 Elevated filter bed
US3642004 *5 janv. 197015 févr. 1972Life Support Equipment CorpUrethral valve
US3714671 *30 nov. 19706 févr. 1973Cutter LabTissue-type heart valve with a graft support ring or stent
US3795246 *26 janv. 19735 mars 1974Bard Inc C RVenocclusion device
US3868956 *5 juin 19724 mars 1975Ralph J AlfidiVessel implantable appliance and method of implanting it
US4425908 *22 oct. 198117 janv. 1984Beth Israel HospitalBlood clot filter
US4501030 *17 août 198126 févr. 1985American Hospital Supply CorporationMethod of leaflet attachment for prosthetic heart valves
US4574803 *17 févr. 198111 mars 1986Karl StorzTissue cutter
US4647283 *13 nov. 19843 mars 1987American Hospital Supply CorporationImplantable biological tissue and process for preparation thereof
US4648881 *29 nov. 198210 mars 1987American Hospital Supply CorporationImplantable biological tissue and process for preparation thereof
US4733665 *7 nov. 198529 mars 1988Expandable Grafts PartnershipExpandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4796629 *3 juin 198710 janv. 1989Joseph GrayzelStiffened dilation balloon catheter device
US4797901 *22 août 198610 janv. 1989Siemens AktiengesellschaftCircuit arrangement for testing a passive bus network with the carrier sense multiple access with collisions detection method
US4909252 *26 mai 198820 mars 1990The Regents Of The Univ. Of CaliforniaPerfusion balloon catheter
US4986830 *22 sept. 198922 janv. 1991Schneider (U.S.A.) Inc.Valvuloplasty catheter with balloon which remains stable during inflation
US4994077 *21 avr. 198919 févr. 1991Dobben Richard LArtificial heart valve for implantation in a blood vessel
US5002559 *30 nov. 198926 mars 1991NumedPTCA catheter
US5089015 *28 nov. 198918 févr. 1992Promedica InternationalMethod for implanting unstented xenografts and allografts
US5197979 *7 sept. 199030 mars 1993Baxter International Inc.Stentless heart valve and holder
US5285635 *22 juin 199315 févr. 1994General Electric CompanyDouble annular combustor
US5295958 *4 avr. 199122 mars 1994Shturman Cardiology Systems, Inc.Method and apparatus for in vivo heart valve decalcification
US5389106 *29 oct. 199314 févr. 1995Numed, Inc.Impermeable expandable intravascular stent
US5397351 *13 mai 199114 mars 1995Pavcnik; DusanProsthetic valve for percutaneous insertion
US5480424 *1 nov. 19932 janv. 1996Cox; James L.Heart valve replacement using flexible tubes
US5489294 *1 févr. 19946 févr. 1996Medtronic, Inc.Steroid eluting stitch-in chronic cardiac lead
US5496346 *25 mai 19935 mars 1996Advanced Cardiovascular Systems, Inc.Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US5500014 *9 mai 199419 mars 1996Baxter International Inc.Biological valvular prothesis
US5591195 *30 oct. 19957 janv. 1997Taheri; SydeApparatus and method for engrafting a blood vessel
US5609626 *22 juin 199411 mars 1997Baxter International Inc.Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts
US5713953 *15 févr. 19963 févr. 1998Sorin Biomedica Cardio S.P.A.Cardiac valve prosthesis particularly for replacement of the aortic valve
US5855597 *7 mai 19975 janv. 1999Iowa-India Investments Co. LimitedStent valve and stent graft for percutaneous surgery
US5855601 *21 juin 19965 janv. 1999The Trustees Of Columbia University In The City Of New YorkArtificial heart valve and method and device for implanting the same
US5860996 *29 avr. 199719 janv. 1999United States Surgical CorporationOptical trocar
US5861028 *9 sept. 199619 janv. 1999Shelhigh IncNatural tissue heart valve and stent prosthesis and method for making the same
US5868448 *5 déc. 19969 févr. 1999Suzuki Motor CorporationGlove box structure
US5868783 *16 avr. 19979 févr. 1999Numed, Inc.Intravascular stent with limited axial shrinkage
US5888201 *13 juin 199730 mars 1999Schneider (Usa) IncTitanium alloy self-expanding stent
US6022370 *25 sept. 19978 févr. 2000Numed, Inc.Expandable stent
US6029671 *22 mai 199629 févr. 2000Heartport, Inc.System and methods for performing endovascular procedures
US6168614 *20 févr. 19982 janv. 2001Heartport, Inc.Valve prosthesis for implantation in the body
US6171335 *22 janv. 19989 janv. 2001Aortech Europe LimitedHeart valve prosthesis
US6192944 *24 avr. 200027 févr. 2001Prodesco, Inc.Method of forming a textile member with undulating wire
US6342070 *14 déc. 199929 janv. 2002Edwards Lifesciences Corp.Stentless bioprosthetic heart valve with patent coronary protuberances and method of surgical use thereof
US6509930 *19 juin 200021 janv. 2003Hitachi, Ltd.Circuit for scan conversion of picture signal using motion compensation
US6676698 *5 déc. 200113 janv. 2004Rex Medicol, L.P.Vascular device with valve for approximating vessel wall
US6692513 *29 juin 200117 févr. 2004Viacor, Inc.Intravascular filter with debris entrapment mechanism
US6695878 *8 juin 200124 févr. 2004Rex Medical, L.P.Vascular device for valve leaflet apposition
US6846325 *7 sept. 200125 janv. 2005Viacor, Inc.Fixation band for affixing a prosthetic heart valve to tissue
US6866650 *2 févr. 200115 mars 2005Heartport, Inc.System for cardiac procedures
US6872223 *1 oct. 200129 mars 2005Boston Scientific CorporationControlled deployment of a medical device
US6986742 *5 mai 200517 janv. 2006Boston Scientific Scimed, Inc.Pressure transducer protection valve
US6989027 *29 avr. 200424 janv. 2006Medtronic Vascular Inc.Percutaneously delivered temporary valve assembly
US6989028 *30 janv. 200224 janv. 2006Edwards Lifesciences AgMedical system and method for remodeling an extravascular tissue structure
US6991649 *30 sept. 200331 janv. 2006Hans-Hinrich SieversArtificial heart valve
US7011681 *13 janv. 200314 mars 2006The Cleveland Clinic FoundationBioprosthetic cardiovascular valve system
US7160319 *14 févr. 20039 janv. 2007Scimed Life Systems, Inc.Multi-section filamentary endoluminal stent
US7175656 *18 avr. 200313 févr. 2007Alexander KhairkhahanPercutaneous transcatheter heart valve replacement
US7316706 *14 juin 20048 janv. 2008Medtronic Vascular, Inc.Tensioning device, system, and method for treating mitral valve regurgitation
US7329278 *13 févr. 200612 févr. 2008Corevalve, Inc.Prosthetic valve for transluminal delivery
US7335218 *28 août 200326 févr. 2008Heart Leaflet Technologies, Inc.Delivery device for leaflet valve
US20020029014 *15 oct. 20017 mars 2002Iowa-India Investments Company, LimitedDelivery mechanism for balloons, drugs, stents and other physical/mechanical agents and method of use
US20020032480 *13 sept. 200114 mars 2002Paul SpenceHeart valve and apparatus for replacement thereof
US20020032481 *9 oct. 200114 mars 2002Shlomo GabbayHeart valve prosthesis and sutureless implantation of a heart valve prosthesis
US20030014104 *2 mai 200216 janv. 2003Alain CribierValue prosthesis for implantation in body channels
US20030023303 *11 avr. 200230 janv. 2003Palmaz Julio C.Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US20030028247 *26 juil. 20026 févr. 2003Cali Douglas S.Method of cutting material for use in implantable medical device
US20030036791 *2 août 200220 févr. 2003Bonhoeffer PhilippImplant implantation unit and procedure for implanting the unit
US20030040771 *16 sept. 200227 févr. 2003Hideki HyodohMethods for creating woven devices
US20030040772 *16 sept. 200227 févr. 2003Hideki HyodohDelivery devices
US20030050694 *13 sept. 200113 mars 2003Jibin YangMethods and apparatuses for deploying minimally-invasive heart valves
US20030055495 *1 nov. 200220 mars 2003Pease Matthew L.Rolled minimally-invasive heart valves and methods of manufacture
US20040034411 *16 août 200219 févr. 2004Quijano Rodolfo C.Percutaneously delivered heart valve and delivery means thereof
US20040039436 *8 août 200326 févr. 2004Benjamin SpenserImplantable prosthetic valve
US20040049224 *5 août 200211 mars 2004Buehlmann Eric L.Target tissue localization assembly and method
US20040049262 *9 juin 200311 mars 2004Obermiller Joseph F.Stent valves and uses of same
US20040049266 *11 sept. 200211 mars 2004Anduiza James PeterPercutaneously deliverable heart valve
US20050010285 *25 févr. 200413 janv. 2005Lambrecht Gregory H.Cardiac valve procedure methods and devices
US20050010287 *1 oct. 200313 janv. 2005Ample Medical, Inc.Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet
US20050015112 *13 nov. 200320 janv. 2005Cohn William E.Cardiac valve procedure methods and devices
US20050033398 *30 juil. 200210 févr. 2005Jacques SeguinAssembly for setting a valve prosthesis in a corporeal duct
US20050043790 *4 juil. 200224 févr. 2005Jacques SeguinKit enabling a prosthetic valve to be placed in a body enabling a prosthetic valve to be put into place in a duct in the body
US20050049692 *2 sept. 20033 mars 2005Numamoto Michael J.Medical device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US20050049696 *13 oct. 20043 mars 2005Thorsten SiessDevice for intravascular cardiac valve surgery
US20050060029 *28 juil. 200417 mars 2005Trong-Phi LeImplantable device as organ valve replacement
US20050060030 *19 juil. 200417 mars 2005Lashinski Randall T.Remotely activated mitral annuloplasty system and methods
US20060004439 *29 juin 20055 janv. 2006Benjamin SpenserDevice and method for assisting in the implantation of a prosthetic valve
US20060009841 *9 sept. 200512 janv. 2006Rex MedicalPercutaneous aortic valve
US20060058775 *3 mai 200516 mars 2006Stevens John HSystem and methods for performing endovascular procedures
US20070005129 *5 sept. 20064 janv. 2007Christoph DammAnchoring system for implantable heart valve prostheses
US20070005131 *13 juin 20054 janv. 2007Taylor David MHeart valve delivery system
US20070010878 *11 nov. 200411 janv. 2007Medtronic Vascular, Inc.Coronary sinus approach for repair of mitral valve regurgitation
US20070016286 *20 juil. 200418 janv. 2007Herrmann Howard CPercutaneous heart valve
US20070027518 *1 avr. 20041 févr. 2007Case Brian CPercutaneously deployed vascular valves
US20070043432 *9 févr. 200522 févr. 2007Eric PerouseTubular prosthesis
US20070043435 *15 mai 200622 févr. 2007Jacques SeguinNon-cylindrical prosthetic valve system for transluminal delivery
US20070051377 *12 nov. 20048 mars 2007Medtronic Vascular, Inc.Cardiac valve annulus reduction system
US20080015671 *21 nov. 200517 janv. 2008Philipp BonhoefferMethod And Apparatus For Treatment Of Cardiac Valves
US20080021552 *30 juil. 200724 janv. 2008Shlomo GabbayApparatus To Facilitate Implantation
Référencé par
Brevet citant Date de dépôt Date de publication Déposant Titre
US74702857 févr. 200530 déc. 2008Children's Medical Center Corp.Transcatheter delivery of a replacement heart valve
US75788431 avr. 200325 août 2009Medtronic, Inc.Heart valve prosthesis
US76703687 févr. 20052 mars 2010Boston Scientific Scimed, Inc.Venous valve apparatus, system, and method
US76823853 juil. 200623 mars 2010Boston Scientific CorporationArtificial valve
US768239030 juil. 200223 mars 2010Medtronic, Inc.Assembly for setting a valve prosthesis in a corporeal duct
US770877524 mai 20064 mai 2010Edwards Lifesciences CorporationMethods for rapid deployment of prosthetic heart valves
US772266615 avr. 200525 mai 2010Boston Scientific Scimed, Inc.Valve apparatus, system and method
US77406556 avr. 200622 juin 2010Medtronic Vascular, Inc.Reinforced surgical conduit for implantation of a stented valve therein
US77586065 févr. 200420 juil. 2010Medtronic, Inc.Intravascular filter with debris entrapment mechanism
US777146924 oct. 200710 août 2010Medtronic, Inc.Method for implantation of fixation band and prosthetic heart valve to tissue
US777605312 déc. 200617 août 2010Boston Scientific Scimed, Inc.Implantable valve system
US778062716 juil. 200724 août 2010Boston Scientific Scimed, Inc.Valve treatment catheter and methods
US77807227 févr. 200524 août 2010Boston Scientific Scimed, Inc.Venous valve apparatus, system, and method
US778072627 juil. 200724 août 2010Medtronic, Inc.Assembly for placing a prosthetic valve in a duct in the body
US778534125 févr. 200531 août 2010Aortx, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US779903820 janv. 200621 sept. 2010Boston Scientific Scimed, Inc.Translumenal apparatus, system, and method
US781991519 déc. 200326 oct. 2010Edwards Lifesciences CorporationHeart valve holders and handling clips therefor
US78547551 févr. 200521 déc. 2010Boston Scientific Scimed, Inc.Vascular catheter, system, and method
US785476119 déc. 200321 déc. 2010Boston Scientific Scimed, Inc.Methods for venous valve replacement with a catheter
US786727423 févr. 200511 janv. 2011Boston Scientific Scimed, Inc.Valve apparatus, system and method
US787143615 févr. 200818 janv. 2011Medtronic, Inc.Replacement prosthetic heart valves and methods of implantation
US789227621 déc. 200722 févr. 2011Boston Scientific Scimed, Inc.Valve with delayed leaflet deployment
US78922815 janv. 200922 févr. 2011Medtronic Corevalve LlcProsthetic valve for transluminal delivery
US791456913 mai 200529 mars 2011Medtronics Corevalve LlcHeart valve prosthesis and methods of manufacture and use
US795118927 juil. 200931 mai 2011Boston Scientific Scimed, Inc.Venous valve, system, and method with sinus pocket
US79511976 avr. 200931 mai 2011Medtronic, Inc.Two-piece prosthetic valves with snap-in connection and methods for use
US79596743 mars 200414 juin 2011Medtronic, Inc.Suture locking assembly and method of use
US79678535 févr. 200828 juin 2011Boston Scientific Scimed, Inc.Percutaneous valve, system and method
US796785729 janv. 200728 juin 2011Medtronic, Inc.Gasket with spring collar for prosthetic heart valves and methods for making and using them
US797237729 août 20085 juil. 2011Medtronic, Inc.Bioprosthetic heart valve
US797237823 janv. 20095 juil. 2011Medtronic, Inc.Stents for prosthetic heart valves
US798115314 mars 200519 juil. 2011Medtronic, Inc.Biologically implantable prosthesis methods of using
US800282423 juil. 200923 août 2011Boston Scientific Scimed, Inc.Cardiac valve, system, and method
US800282614 oct. 200923 août 2011Medtronic Corevalve LlcAssembly for placing a prosthetic valve in a duct in the body
US801219810 juin 20056 sept. 2011Boston Scientific Scimed, Inc.Venous valve, system, and method
US801687729 juin 200913 sept. 2011Medtronic Corevalve LlcProsthetic valve for transluminal delivery
US80211611 mai 200620 sept. 2011Edwards Lifesciences CorporationSimulated heart valve root for training and testing
US802142122 août 200320 sept. 2011Medtronic, Inc.Prosthesis heart valve fixturing device
US802569531 janv. 200327 sept. 2011Medtronic, Inc.Biologically implantable heart valve system
US805275023 mars 20078 nov. 2011Medtronic Ventor Technologies LtdValve prosthesis fixation techniques using sandwiching
US80708003 mai 20076 déc. 2011Children's Medical Center CorporationTranscatheter heart valve prostheses
US807080123 févr. 20096 déc. 2011Medtronic, Inc.Method and apparatus for resecting and replacing an aortic valve
US807561528 mars 200713 déc. 2011Medtronic, Inc.Prosthetic cardiac valve formed from pericardium material and methods of making same
US809248714 juin 201010 janv. 2012Medtronic, Inc.Intravascular filter with debris entrapment mechanism
US80925243 déc. 200810 janv. 2012Children's Medical Center CorporationTranscatheter delivery of a replacement heart valve
US810537710 août 201031 janv. 2012Medtronic, Inc.Fixation band for affixing a prosthetic heart valve to tissue
US812868119 déc. 20036 mars 2012Boston Scientific Scimed, Inc.Venous valve apparatus, system, and method
US812869225 févr. 20056 mars 2012Aortx, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US81332708 janv. 200813 mars 2012California Institute Of TechnologyIn-situ formation of a valve
US813739414 janv. 201120 mars 2012Boston Scientific Scimed, Inc.Valve with delayed leaflet deployment
US813739813 oct. 200820 mars 2012Medtronic Ventor Technologies LtdProsthetic valve having tapered tip when compressed for delivery
US814249220 juin 200727 mars 2012Aortx, Inc.Prosthetic valve implantation systems
US814754127 févr. 20063 avr. 2012Aortx, Inc.Methods and devices for delivery of prosthetic heart valves and other prosthetics
US815785222 janv. 200917 avr. 2012Medtronic, Inc.Delivery systems and methods of implantation for prosthetic heart valves
US815785322 janv. 200917 avr. 2012Medtronic, Inc.Delivery systems and methods of implantation for prosthetic heart valves
US821116926 mai 20063 juil. 2012Medtronic, Inc.Gasket with collar for prosthetic heart valves and methods for using them
US822671025 mars 201124 juil. 2012Medtronic Corevalve, Inc.Heart valve prosthesis and methods of manufacture and use
US824667715 févr. 200821 août 2012Medtronic, Inc.Delivery systems and methods of implantation for replacement prosthetic heart valves
US830879810 déc. 200913 nov. 2012Edwards Lifesciences CorporationQuick-connect prosthetic heart valve and methods
US831282516 avr. 200920 nov. 2012Medtronic, Inc.Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US831352518 mars 200820 nov. 2012Medtronic Ventor Technologies, Ltd.Valve suturing and implantation procedures
US834899523 mars 20078 janv. 2013Medtronic Ventor Technologies, Ltd.Axial-force fixation member for valve
US834899623 mars 20078 janv. 2013Medtronic Ventor Technologies Ltd.Valve prosthesis implantation techniques
US834899823 juin 20108 janv. 2013Edwards Lifesciences CorporationUnitary quick connect prosthetic heart valve and deployment system and methods
US834899913 févr. 20128 janv. 2013California Institute Of TechnologyIn-situ formation of a valve
US834900312 avr. 20118 janv. 2013Medtronic, Inc.Suture locking assembly and method of use
US837686519 juin 200719 févr. 2013Cardiacmd, Inc.Torque shaft and torque shaft drive
US840398127 févr. 200626 mars 2013CardiacMC, Inc.Methods and devices for delivery of prosthetic heart valves and other prosthetics
US84146412 mars 20129 avr. 2013Boston Scientific Scimed, Inc.Valve with delayed leaflet deployment
US841464323 mars 20079 avr. 2013Medtronic Ventor Technologies Ltd.Sinus-engaging valve fixation member
US841464527 août 20109 avr. 2013Medtronic, Inc.Transcatheter valve delivery systems and methods
US843092525 févr. 200530 avr. 2013Cardiacmd, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US84309272 févr. 200930 avr. 2013Medtronic, Inc.Multiple orifice implantable heart valve and methods of implantation
US844962527 oct. 200928 mai 2013Edwards Lifesciences CorporationMethods of measuring heart valve annuluses for valve replacement
US846036527 mai 201111 juin 2013Boston Scientific Scimed, Inc.Venous valve, system, and method with sinus pocket
US84603731 juil. 201111 juin 2013Medtronic, Inc.Method for implanting a heart valve within an annulus of a patient
US847002322 juin 201125 juin 2013Boston Scientific Scimed, Inc.Percutaneous valve, system, and method
US850079824 mai 20066 août 2013Edwards Lifesciences CorporationRapid deployment prosthetic heart valve
US850079920 juin 20076 août 2013Cardiacmd, Inc.Prosthetic heart valves, support structures and systems and methods for implanting same
US85008028 mars 20116 août 2013Medtronic, Inc.Two-piece prosthetic valves with snap-in connection and methods for use
US850662013 nov. 200913 août 2013Medtronic, Inc.Prosthetic cardiac and venous valves
US85066259 août 201013 août 2013Edwards Lifesciences CorporationContoured sewing ring for a prosthetic mitral heart valve
US851124419 oct. 201220 août 2013Medtronic, Inc.Methods and apparatuses for assembly of a pericardial prosthetic heart valve
US851239727 avr. 200920 août 2013Sorin Group Italia S.R.L.Prosthetic vascular conduit
US851239928 déc. 200920 août 2013Boston Scientific Scimed, Inc.Valve apparatus, system and method
US85124009 avr. 201020 août 2013Medtronic, Inc.Transcatheter heart valve delivery system with reduced area moment of inertia
US851240112 avr. 201020 août 2013Medtronic, Inc.Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US853537316 juin 200817 sept. 2013Sorin Group Italia S.R.L.Minimally-invasive cardiac-valve prosthesis
US853966216 juin 200824 sept. 2013Sorin Group Italia S.R.L.Cardiac-valve prosthesis
US854076830 déc. 201124 sept. 2013Sorin Group Italia S.R.L.Cardiac valve prosthesis
US855116220 déc. 20028 oct. 2013Medtronic, Inc.Biologically implantable prosthesis
US856267218 nov. 200522 oct. 2013Medtronic, Inc.Apparatus for treatment of cardiac valves and method of its manufacture
US856267321 sept. 201022 oct. 2013Medtronic, Inc.Stented transcatheter prosthetic heart valve delivery system and method
US856847426 avr. 201129 oct. 2013Medtronic, Inc.Transcatheter prosthetic heart valve post-dilatation remodeling devices and methods
US857425710 août 20095 nov. 2013Edwards Lifesciences CorporationSystem, device, and method for providing access in a cardiovascular environment
US85799664 févr. 200412 nov. 2013Medtronic Corevalve LlcProsthetic valve for transluminal delivery
US859157014 mars 200826 nov. 2013Medtronic, Inc.Prosthetic heart valve for replacing previously implanted heart valve
US860315911 déc. 200910 déc. 2013Medtronic Corevalve, LlcProsthetic valve for transluminal delivery
US86031616 juil. 200910 déc. 2013Medtronic, Inc.Attachment device and methods of using the same
US860877028 juil. 201017 déc. 2013Cardiacmd, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US86137657 juil. 201124 déc. 2013Medtronic, Inc.Prosthetic heart valve systems
US862307415 févr. 20087 janv. 2014Medtronic, Inc.Delivery systems and methods of implantation for replacement prosthetic heart valves
US862307521 avr. 20117 janv. 2014Medtronic, Inc.Transcatheter prosthetic heart valve delivery system and method with controlled expansion of prosthetic heart valve
US86230775 déc. 20117 janv. 2014Medtronic, Inc.Apparatus for replacing a cardiac valve
US862308022 sept. 20117 janv. 2014Medtronic, Inc.Biologically implantable prosthesis and methods of using the same
US862856623 janv. 200914 janv. 2014Medtronic, Inc.Stents for prosthetic heart valves
US862857018 août 201114 janv. 2014Medtronic Corevalve LlcAssembly for placing a prosthetic valve in a duct in the body
US864175723 juin 20114 févr. 2014Edwards Lifesciences CorporationSystems for rapidly deploying surgical heart valves
US865220323 sept. 201118 févr. 2014Cardiaq Valve Technologies, Inc.Replacement heart valves, delivery devices and methods
US865220430 juil. 201018 févr. 2014Medtronic, Inc.Transcatheter valve with torsion spring fixation and related systems and methods
US866331823 juil. 20074 mars 2014Hocor Cardiovascular Technologies LlcMethod and apparatus for percutaneous aortic valve replacement
US866331925 juil. 20084 mars 2014Hocor Cardiovascular Technologies LlcMethods and apparatus for percutaneous aortic valve replacement
US867299724 avr. 201218 mars 2014Boston Scientific Scimed, Inc.Valve with sinus
US867300020 mai 201118 mars 2014Medtronic, Inc.Stents for prosthetic heart valves
US868507714 mars 20121 avr. 2014Medtronics, Inc.Delivery systems and methods of implantation for prosthetic heart valves
US868508428 déc. 20121 avr. 2014Sorin Group Italia S.R.L.Prosthetic vascular conduit and assembly method
US869668918 mars 200815 avr. 2014Medtronic Ventor Technologies Ltd.Medical suturing device and method for use thereof
US869674210 oct. 201215 avr. 2014Edwards Lifesciences CorporationUnitary quick-connect prosthetic heart valve deployment methods
US869674316 avr. 200915 avr. 2014Medtronic, Inc.Tissue attachment devices and methods for prosthetic heart valves
US872170823 sept. 201113 mai 2014Medtronic Corevalve LlcProsthetic valve for transluminal delivery
US872171417 sept. 200813 mai 2014Medtronic Corevalve LlcDelivery system for deployment of medical devices
US872171727 janv. 201213 mai 2014Boston Scientific Scimed, Inc.Venous valve apparatus, system, and method
US872815630 janv. 201220 mai 2014Cardiac MD, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US874097621 avr. 20113 juin 2014Medtronic, Inc.Transcatheter prosthetic heart valve delivery system with flush report
US874745820 août 200710 juin 2014Medtronic Ventor Technologies Ltd.Stent loading tool and method for use thereof
US87474596 déc. 200710 juin 2014Medtronic Corevalve LlcSystem and method for transapical delivery of an annulus anchored self-expanding valve
US874746023 déc. 201110 juin 2014Medtronic Ventor Technologies Ltd.Methods for implanting a valve prothesis
US87474633 août 201110 juin 2014Medtronic, Inc.Methods of using a prosthesis fixturing device
US87713026 avr. 20078 juil. 2014Medtronic, Inc.Method and apparatus for resecting and replacing an aortic valve
US877134415 août 20138 juil. 2014Medtronic, Inc.Transcatheter heart valve delivery system with reduced area moment of inertia
US877134531 oct. 20118 juil. 2014Medtronic Ventor Technologies Ltd.Valve prosthesis fixation techniques using sandwiching
US877134625 juil. 20118 juil. 2014Medtronic Ventor Technologies Ltd.Valve prosthetic fixation techniques using sandwiching
US877798023 déc. 201115 juil. 2014Medtronic, Inc.Intravascular filter with debris entrapment mechanism
US878447816 oct. 200722 juil. 2014Medtronic Corevalve, Inc.Transapical delivery system with ventruculo-arterial overlfow bypass
US879535621 févr. 20145 août 2014Cardiaq Valve Technologies, Inc.Vascular implant
US880177624 févr. 200912 août 2014Medtronic Vascular, Inc.Infundibular reducer devices
US880177910 mai 201112 août 2014Medtronic Corevalve, LlcProsthetic valve for transluminal delivery
US88083695 oct. 201019 août 2014Mayo Foundation For Medical Education And ResearchMinimally invasive aortic valve replacement
US882156930 avr. 20072 sept. 2014Medtronic, Inc.Multiple component prosthetic heart valve assemblies and methods for delivering them
US882807926 juil. 20079 sept. 2014Boston Scientific Scimed, Inc.Circulatory valve, system and method
US883456316 déc. 200916 sept. 2014Sorin Group Italia S.R.L.Expandable prosthetic valve having anchoring appendages
US883456411 mars 201016 sept. 2014Medtronic, Inc.Sinus-engaging valve fixation member
US884066113 mai 200923 sept. 2014Sorin Group Italia S.R.L.Atraumatic prosthetic heart valve prosthesis
US884572020 sept. 201130 sept. 2014Edwards Lifesciences CorporationProsthetic heart valve frame with flexible commissures
US885227127 avr. 20117 oct. 2014Medtronic Vascular, Inc.Transcatheter prosthetic heart valve delivery device with biased release features
US887689221 avr. 20114 nov. 2014Medtronic, Inc.Prosthetic heart valve delivery system with spacing
US887689327 avr. 20114 nov. 2014Medtronic, Inc.Transcatheter prosthetic heart valve delivery device with passive trigger release
US887689423 mars 20074 nov. 2014Medtronic Ventor Technologies Ltd.Leaflet-sensitive valve fixation member
US887689523 mars 20074 nov. 2014Medtronic Ventor Technologies Ltd.Valve fixation member having engagement arms
US88768967 déc. 20114 nov. 2014Medtronic Corevalve LlcProsthetic valve for transluminal delivery
US889470222 janv. 201325 nov. 2014Cardiaq Valve Technologies, Inc.Replacement heart valve and method
US891145521 déc. 201216 déc. 2014Cardiaq Valve Technologies, Inc.Delivery system for vascular implant
US891149330 juil. 201316 déc. 2014Edwards Lifesciences CorporationRapid deployment prosthetic heart valves
US892049221 août 201330 déc. 2014Sorin Group Italia S.R.L.Cardiac valve prosthesis
US89266929 avr. 20106 janv. 2015Medtronic, Inc.Transcatheter prosthetic heart valve delivery device with partial deployment and release features and methods
US893234922 août 201113 janv. 2015Boston Scientific Scimed, Inc.Cardiac valve, system, and method
US89512809 juin 201010 févr. 2015Medtronic, Inc.Cardiac valve procedure methods and devices
US895640214 sept. 201217 févr. 2015Medtronic, Inc.Apparatus for replacing a cardiac valve
US89615935 déc. 201324 févr. 2015Medtronic, Inc.Prosthetic heart valve systems
US897452417 oct. 201310 mars 2015Medtronic, Inc.Stented transcatheter prosthetic heart valve delivery system and method
US898632928 oct. 201324 mars 2015Medtronic Corevalve LlcMethods for transluminal delivery of prosthetic valves
US898636117 oct. 200824 mars 2015Medtronic Corevalve, Inc.Delivery system for deployment of medical devices
US898637219 août 201324 mars 2015Medtronic, Inc.Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US898637410 mai 201124 mars 2015Edwards Lifesciences CorporationProsthetic heart valve
US899897911 févr. 20147 avr. 2015Medtronic Corevalve LlcTranscatheter heart valves
US89989809 avr. 20107 avr. 2015Medtronic, Inc.Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US899898115 sept. 20097 avr. 2015Medtronic, Inc.Prosthetic heart valve having identifiers for aiding in radiographic positioning
US900527721 déc. 201214 avr. 2015Edwards Lifesciences CorporationUnitary quick-connect prosthetic heart valve deployment system
US900527825 oct. 201214 avr. 2015Edwards Lifesciences CorporationQuick-connect prosthetic heart valve
US902310031 janv. 20135 mai 2015Cardiaq Valve Technologies, Inc.Replacement heart valves, delivery devices and methods
US90285426 sept. 201112 mai 2015Boston Scientific Scimed, Inc.Venous valve, system, and method
US906085611 févr. 201423 juin 2015Medtronic Corevalve LlcTranscatheter heart valves
US906085719 juin 201223 juin 2015Medtronic Corevalve LlcHeart valve prosthesis and methods of manufacture and use
US906085913 juil. 201223 juin 2015Medtronic, Inc.Delivery systems and methods of implantation for replacement prosthetic heart valves
US906679920 janv. 201130 juin 2015Medtronic Corevalve LlcProsthetic valve for transluminal delivery
US907874713 nov. 201214 juil. 2015Edwards Lifesciences CorporationAnchoring device for replacing or repairing a heart valve
US9078993 *1 nov. 201214 juil. 2015Vascular Solutions, Inc.Aortic valve positioning systems, devices, and methods
US9089422 *23 janv. 200928 juil. 2015Medtronic, Inc.Markers for prosthetic heart valves
US912574112 mars 20138 sept. 2015Edwards Lifesciences CorporationSystems and methods for ensuring safe and rapid deployment of prosthetic heart valves
US91320083 oct. 201415 sept. 2015Medtronic, Inc.Transcatheter prosthetic heart valve delivery device with passive trigger release
US91383126 juin 201422 sept. 2015Medtronic Ventor Technologies Ltd.Valve prostheses
US913831410 févr. 201422 sept. 2015Sorin Group Italia S.R.L.Prosthetic vascular conduit and assembly method
US914935723 déc. 20136 oct. 2015Medtronic CV Luxembourg S.a.r.l.Heart valve assemblies
US914935823 janv. 20096 oct. 2015Medtronic, Inc.Delivery systems for prosthetic heart valves
US915561718 avr. 201413 oct. 2015Edwards Lifesciences CorporationProsthetic mitral valve
US916183610 févr. 201220 oct. 2015Sorin Group Italia S.R.L.Sutureless anchoring device for cardiac valve prostheses
US916813421 déc. 201127 oct. 2015Cardiacmd, Inc.Method for delivering a prosthetic heart valve with an expansion member
US91737383 déc. 20133 nov. 2015Medtronic, Inc.Transcatheter prosthetic heart valve delivery system and method with controlled expansion of prosthetic heart valve
US919246823 janv. 201424 nov. 2015Kardium Inc.Method for anchoring a mitral valve
US920496413 juin 20138 déc. 2015Kardium Inc.Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
US922682624 févr. 20105 janv. 2016Medtronic, Inc.Transcatheter valve structure and methods for valve delivery
US923788614 avr. 200819 janv. 2016Medtronic, Inc.Implant for treatment of a heart valve, in particular a mitral valve, material including such an implant, and material for insertion thereof
US9241792 *25 févr. 200926 janv. 2016Edwards Lifesciences CorporationTwo-step heart valve implantation
US92480163 mars 20102 févr. 2016Edwards Lifesciences CorporationProsthetic heart valve system
US924801720 mai 20112 févr. 2016Sorin Group Italia S.R.L.Support device for valve prostheses and corresponding kit
US928928910 févr. 201222 mars 2016Sorin Group Italia S.R.L.Sutureless anchoring device for cardiac valve prostheses
US929555028 mars 201429 mars 2016Medtronic CV Luxembourg S.a.r.l.Methods for delivering a self-expanding valve
US930183416 oct. 20095 avr. 2016Medtronic Ventor Technologies Ltd.Sinus-engaging valve fixation member
US930184310 nov. 20105 avr. 2016Boston Scientific Scimed, Inc.Venous valve apparatus, system, and method
US93080867 sept. 201112 avr. 2016Hocor Cardiovascular Technologies LlcMethod and system for balloon counterpulsation during aortic valve replacement
US931433425 nov. 201319 avr. 2016Edwards Lifesciences CorporationConformal expansion of prosthetic devices to anatomical shapes
US931433519 sept. 200819 avr. 2016Edwards Lifesciences CorporationProsthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
US933132812 déc. 20113 mai 2016Medtronic, Inc.Prosthetic cardiac valve from pericardium material and methods of making same
US9333073 *11 nov. 201410 mai 2016Edwards Lifesciences Cardiaq LlcVascular implant and delivery method
US9333074 *16 janv. 201510 mai 2016Edwards Lifesciences Cardiaq LlcVascular implant and delivery system
US933307712 mars 201310 mai 2016Medtronic Vascular Galway LimitedDevices and methods for preparing a transcatheter heart valve system
US933307822 nov. 201310 mai 2016Medtronic, Inc.Heart valve assemblies
US933310022 nov. 201310 mai 2016Medtronic, Inc.Stents for prosthetic heart valves
US93393775 mars 201317 mai 2016Edwards Lifesciences Cardiaq LlcBody cavity prosthesis
US9339378 *31 janv. 201317 mai 2016Edwards Lifesciences Cardiaq LlcVascular implant and delivery system
US9339379 *31 janv. 201317 mai 2016Edwards Lifesciences Cardiaq LlcVascular implant and delivery system
US9339380 *21 févr. 201417 mai 2016Edwards Lifesciences Cardiaq LlcVascular implant
US933938224 janv. 201417 mai 2016Medtronic, Inc.Stents for prosthetic heart valves
US936432220 déc. 201314 juin 2016Edwards Lifesciences CorporationPost-implant expandable surgical heart valve configurations
US937041812 mars 201321 juin 2016Edwards Lifesciences CorporationRapidly deployable surgical heart valves
US937041930 nov. 201021 juin 2016Boston Scientific Scimed, Inc.Valve apparatus, system and method
US937531020 déc. 201328 juin 2016Edwards Lifesciences CorporationSurgical heart valves adapted for post-implant expansion
US938707112 sept. 201412 juil. 2016Medtronic, Inc.Sinus-engaging valve fixation member
US939311227 févr. 201419 juil. 2016Medtronic Ventor Technologies Ltd.Stent loading tool and method for use thereof
US939311523 janv. 200919 juil. 2016Medtronic, Inc.Delivery systems and methods of implantation for prosthetic heart valves
US942108324 juin 201323 août 2016Boston Scientific Scimed Inc.Percutaneous valve, system and method
US94335149 janv. 20126 sept. 2016Edwards Lifesciences Cardiaq LlcMethod of securing a prosthesis
US943976223 janv. 201313 sept. 2016Edwards Lifesciences CorporationMethods of implant of a heart valve with a convertible sewing ring
US945689622 janv. 20134 oct. 2016Edwards Lifesciences Cardiaq LlcBody cavity prosthesis
US945689919 sept. 20134 oct. 2016Medtronic, Inc.Transcatheter prosthetic heart valve post-dilatation remodeling devices and methods
US946852712 juin 201418 oct. 2016Edwards Lifesciences CorporationCardiac implant with integrated suture fasteners
US9474597 *21 juil. 201125 oct. 2016Kevin D. AccolaProsthetic heart valves and devices, systems and methods for prosthetic heart valves
US94746097 oct. 201525 oct. 2016Boston Scientific Scimed, Inc.Venous valve, system, and method with sinus pocket
US948055623 oct. 20131 nov. 2016Medtronic, Inc.Replacement prosthetic heart valve, system and method of implant
US948056031 janv. 20131 nov. 2016Edwards Lifesciences Cardiaq LlcMethod of securing an intralumenal frame assembly
US948056414 janv. 20141 nov. 2016Hocor Cardiovascular Technologies, LlcMethods and apparatus for percutaneous aortic valve replacement
US948631319 nov. 20148 nov. 2016Sorin Group Italia S.R.L.Cardiac valve prosthesis
US9486336 *22 janv. 20138 nov. 2016Edwards Lifesciences Cardiaq LlcProsthesis having a plurality of distal and proximal prongs
US949832921 oct. 201322 nov. 2016Medtronic, Inc.Apparatus for treatment of cardiac valves and method of its manufacture
US20040138741 *19 déc. 200315 juil. 2004Robert StobieHeart valve holders and handling clips therefor
US20050203614 *25 févr. 200515 sept. 2005Cardiacmd, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US20050203615 *25 févr. 200515 sept. 2005Cardiacmd, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US20050203617 *25 févr. 200515 sept. 2005Cardiacmd, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same
US20050203618 *3 déc. 200415 sept. 2005Adam SharkawyProsthetic cardiac valves and systems and methods for implanting thereof
US20050228494 *29 mars 200413 oct. 2005Salvador MarquezControlled separation heart valve frame
US20050234546 *7 févr. 200520 oct. 2005Alan NugentTranscatheter delivery of a replacement heart valve
US20060206202 *18 nov. 200514 sept. 2006Philippe BonhoefferApparatus for treatment of cardiac valves and method of its manufacture
US20060253189 *3 juil. 20069 nov. 2006Boston Scientific CorporationArtificial valve
US20060287717 *24 mai 200621 déc. 2006Rowe Stanton JMethods for rapid deployment of prosthetic heart valves
US20060287719 *24 mai 200621 déc. 2006Rowe Stanton JRapid deployment prosthetic heart valve
US20070073387 *1 sept. 200629 mars 2007Forster David CProsthetic Heart Valves, Support Structures And Systems And Methods For Implanting The Same
US20070162113 *16 févr. 200712 juil. 2007Adam SharkawyProsthetic cardiac valves and systems and methods for implanting thereof
US20070203561 *27 févr. 200630 août 2007Cardiacmd, Inc. A California CorporationMethods and devices for delivery of prosthetic heart valves and other prosthetics
US20070203575 *27 févr. 200630 août 2007Cardiacmd, Inc., A California CorporationMethods and devices for delivery of prosthetic heart valves and other prosthetics
US20070239265 *6 avr. 200611 oct. 2007Medtronic Vascular, Inc.Catheter Delivered Valve Having a Barrier to Provide an Enhanced Seal
US20070239266 *6 avr. 200611 oct. 2007Medtronic Vascular, Inc.Reinforced Surgical Conduit for Implantation of a Stented Valve Therein
US20070239269 *7 avr. 200611 oct. 2007Medtronic Vascular, Inc.Stented Valve Having Dull Struts
US20070244544 *14 avr. 200618 oct. 2007Medtronic Vascular, Inc.Seal for Enhanced Stented Valve Fixation
US20070244545 *14 avr. 200618 oct. 2007Medtronic Vascular, Inc.Prosthetic Conduit With Radiopaque Symmetry Indicators
US20070244546 *18 avr. 200618 oct. 2007Medtronic Vascular, Inc.Stent Foundation for Placement of a Stented Valve
US20070254273 *1 mai 20061 nov. 2007Hugues LafranceSimulated heart valve root for training and testing
US20080065206 *24 oct. 200713 mars 2008Liddicoat John RFixation band for affixing a prosthetic heart valve to tissue
US20080071366 *23 mars 200720 mars 2008Yosi TuvalAxial-force fixation member for valve
US20080126131 *17 juil. 200629 mai 2008Walgreen Co.Predictive Modeling And Risk Stratification Of A Medication Therapy Regimen
US20080161910 *14 mars 20083 juil. 2008Revuelta Jose MReplacement prosthetic heart valve, system and method of implant
US20080208327 *27 févr. 200728 août 2008Rowe Stanton JMethod and apparatus for replacing a prosthetic valve
US20080215144 *15 févr. 20084 sept. 2008Ryan Timothy RReplacement prosthetic heart valves and methods of implantation
US20080228254 *15 févr. 200818 sept. 2008Ryan Timothy RDelivery systems and methods of implantation for replacement prosthetic heart valves
US20080228263 *15 févr. 200818 sept. 2008Ryan Timothy RDelivery systems and methods of implantation for replacement prosthetic heart valves
US20090030503 *23 juil. 200729 janv. 2009Ho Paul CMethod and apparatus for percutaneous aortic valve replacement
US20090030510 *25 juil. 200829 janv. 2009Ho Paul CMethods and apparatus for percutaneous aortic valve replacement
US20090082858 *3 déc. 200826 mars 2009Children's Medical Center CorporationTranscatheter Delivery of a Replacement Heart Valve
US20090099554 *30 sept. 200816 avr. 2009Forster David CElongate Flexible Torque Instruments And Methods Of Use
US20090132035 *12 sept. 200821 mai 2009Roth Alex TProsthetic Heart Valves, Support Structures and Systems and Methods for Implanting the Same
US20090138079 *9 oct. 200828 mai 2009Vector Technologies Ltd.Prosthetic heart valve for transfemoral delivery
US20090192591 *23 janv. 200930 juil. 2009Medtronic, Inc.Markers for Prosthetic Heart Valves
US20090210052 *20 juin 200720 août 2009Forster David CProsthetic heart valves, support structures and systems and methods for implanting same
US20090222082 *3 mai 20073 sept. 2009Children's Medical Center CorporationTranscatheter Heart Valve Prostheses
US20090228098 *20 juin 200710 sept. 2009Forster David CProsthetic valve implantation systems
US20090240264 *18 mars 200824 sept. 2009Yosi TuvalMedical suturing device and method for use thereof
US20090281609 *25 févr. 200912 nov. 2009Edwards LifesciencesTwo-step heart valve implantation
US20090287299 *23 janv. 200919 nov. 2009Charles TaborStents for prosthetic heart valves
US20100049306 *24 févr. 200925 févr. 2010Medtronic Vascular, Inc.Infundibular Reducer Devices
US20100063363 *10 août 200911 mars 2010Hamman Baron LSystem, device, and method for providing access in a cardiovascular environment
US20100076548 *19 sept. 200825 mars 2010Edwards Lifesciences CorporationProsthetic Heart Valve Configured to Receive a Percutaneous Prosthetic Heart Valve Implantation
US20100179634 *2 nov. 200915 juil. 2010Forster David CMethods and Devices for Delivery of Prosthetic Heart Valves and Other Prosthetics
US20100249894 *3 mars 201030 sept. 2010Edwards Lifesciences CorporationProsthetic heart valve system
US20100249908 *2 mars 201030 sept. 2010Edwards Lifesciences CorporationProsthetic heart valve system with positioning markers
US20100256724 *7 avr. 20107 oct. 2010Forster David CProsthetic Heart Valves, Scaffolding Structures, and Systems and Methods for Implantation of Same
US20100256752 *6 sept. 20077 oct. 2010Forster David CProsthetic heart valves, support structures and systems and methods for implanting the same,
US20100305691 *28 juil. 20102 déc. 2010Forster David CProsthetic Heart Valves, Scaffolding Structures, and Systems and Methods for Implantation of Same
US20110054598 *9 août 20103 mars 2011Edwards Lifesciences CorporationContoured Sewing Ring for a Prosthetic Mitral Heart Valve
US20110082540 *15 nov. 20107 avr. 2011Forster David CProsthetic Heart Valves, Scaffolding Structures, and Systems and Methods for Implantation of Same
US20110098602 *27 oct. 200928 avr. 2011Edwards Lifesciences CorporationApparatus and Method for Measuring Body Orifice
US20110098804 *21 sept. 201028 avr. 2011Hubert YeungStented transcatheter prosthetic heart valve delivery system and method
US20110098805 *27 août 201028 avr. 2011Joshua DworkTranscatheter valve delivery systems and methods
US20110190877 *8 mars 20114 août 2011Medtronic, Inc.Two-Piece Prosthetic Valves with Snap-In Connection and Methods for Use
US20130041405 *15 oct. 201214 févr. 2013Kardium Inc.Method and device for closing holes in tissue
US20130109960 *1 nov. 20122 mai 2013Vascular Solutions, Inc.Aortic valve positioning systems, devices, and methods
US20130138207 *31 janv. 201330 mai 2013Cardiaq Valve Technologies, Inc.Vascular implant and delivery system
US20130144380 *31 janv. 20136 juin 2013Cardiaq Valve Technologies, Inc.Vascular implant and delivery system
US20130261741 *21 juil. 20113 oct. 2013Kevin D. AccolaProsthetic Heart Valves and Devices, Systems and Methods for Prosthetic Heart Valves
US20140172086 *21 févr. 201419 juin 2014Cardiaq Valve Technologies, Inc.Vascular implant and delivery system
US20140276616 *13 mars 201418 sept. 2014Syntheon Cardiology, LlcCatheter-based devices and methods for identifying specific anatomical landmarks of the human aortic valve
US20140309731 *24 juin 201416 oct. 2014Cardiaq Valve Technologies, Inc.Vascular implant
USD7326669 août 201123 juin 2015Medtronic Corevalve, Inc.Heart valve prosthesis
USD7553845 mars 20143 mai 2016Edwards Lifesciences Cardiaq LlcStent
DE102011108143A1 *21 juil. 201124 janv. 2013Maximilian KüttingModular system for producing catheter-based heart valve prostheses and prosthesis for other human flap positions, has sail sheet carrying base element and anchoring elements, which is connected to base element
EP2059191A2 *20 juin 200720 mai 2009AorTx, Inc.Prosthetic valve implantation systems
EP2254512A1 *23 janv. 20091 déc. 2010Medtronic, Inc.Markers for prosthetic heart valves
EP2254512B1 *23 janv. 20096 janv. 2016Medtronic, Inc.Markers for prosthetic heart valves
EP2306934A1 *22 juil. 200913 avr. 2011Hocor Cardiovascular Technologies, LlcMethods and apparatus for percutaneous aortic valve replacement
EP2306934A4 *22 juil. 20094 déc. 2013Hocor Cardiovascular Technologies LlcMethods and apparatus for percutaneous aortic valve replacement
WO2008035337A219 sept. 200727 mars 2008Ventor Technologies, Ltd.Fixation member for valve
WO2008100600A1 *15 févr. 200821 août 2008Medtronic, Inc.Replacement prosthetic heart valves and methods of implantation
WO2008103295A2 *15 févr. 200828 août 2008Medtronic, Inc.Replacement prosthetic heart valves and methods of implantation
WO2008103295A3 *15 févr. 200830 oct. 2008Medtronic IncReplacement prosthetic heart valves and methods of implantation
WO2009108615A1 *24 févr. 20093 sept. 2009Medtronic Vascular Inc.Infundibular reducer devices
WO2010045238A213 oct. 200922 avr. 2010Medtronic Ventor Technologies Ltd.Prosthetic valve having tapered tip when compressed for delivery
WO2011068262A1 *3 déc. 20099 juin 2011M.I.Tech Co.,IncStent for bile duct
WO2011106137A13 févr. 20111 sept. 2011Medtronic Inc.Mitral prosthesis
WO2011112706A29 mars 201115 sept. 2011Medtronic Inc.Sinus-engaging fixation member
Classifications
Classification aux États-Unis623/2.18, 623/902, 623/2.38
Classification internationaleA61F2/24
Classification coopérativeA61F2230/0013, A61F2/2418, A61F2220/0016, A61F2220/0008, A61F2230/0078, A61F2250/0039, A61F2250/0063, A61F2/2409
Classification européenneA61F2/24D6
Événements juridiques
DateCodeÉvénementDescription
7 juin 2005ASAssignment
Owner name: MEDTRONIC, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:REVUELT, JOSE M.;LEMMON, JACK D.;RYAN, TIMOTHY R.;REEL/FRAME:023561/0087;SIGNING DATES FROM 20040913 TO 20041004