US20060135994A1 - Barbed Suture in Combination with Surgical Needle - Google Patents
Barbed Suture in Combination with Surgical Needle Download PDFInfo
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- US20060135994A1 US20060135994A1 US11/307,900 US30790006A US2006135994A1 US 20060135994 A1 US20060135994 A1 US 20060135994A1 US 30790006 A US30790006 A US 30790006A US 2006135994 A1 US2006135994 A1 US 2006135994A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/04—Non-resorbable materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06004—Means for attaching suture to needle
- A61B2017/06028—Means for attaching suture to needle by means of a cylindrical longitudinal blind bore machined at the suture-receiving end of the needle, e.g. opposite to needle tip
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B2017/06057—Double-armed sutures, i.e. sutures having a needle attached to each end
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
- A61B2017/06176—Sutures with protrusions, e.g. barbs
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Abstract
Description
- This application is a divisional application of U.S. patent application Ser. No. 10/065,278, filed Sep. 30, 2002, the entire contents of which are incorporated herein by reference.
- This invention relates, in general, to a barbed suture useful for connecting bodily tissue in various surgical contexts, and more particularly, to the optimization of the disposition and/or configuration of the barbs on such barbed sutures.
- Various surgical methods employing sutures have been used in the past for closing or binding together wounds in human or animal tissue, such as skin, muscles, tendons, internal organs, nerves, blood vessels, and the like. More specifically, the surgeon may use a surgical needle with an attached conventional suture (which can be a smooth monofilament or can be a multi-filament) to pierce the tissue alternately on opposing faces of the wound and thus sew the wound closed. Whether the wound is accidental or surgical, loop stitching is the method often used, especially for surface wounds. The surgical needle is then removed and the ends of the suture are tied, typically with at least three overhand throws to form a knot.
- As is well known, conventional sutures can be of non-absorbable material such as silk, nylon, polyester, polypropylene, or cotton, or can be of bio-absorbable material such as glycolic acid polymers and copolymers or lactic acid polymers and copolymers.
- Since the time of their conception, barbed sutures, which are generally of the same materials as conventional sutures, have offered numerous advantages over closing wounds with conventional sutures. A barbed suture includes an elongated body that has one or more spaced barbs, which project from the body surface along the body length. The barbs are arranged to allow passage of the barbed suture in one direction through tissue but resist movement of the barbed suture in the opposite direction. Thus, the main advantage of barbed sutures has been the provision of a non-slip attribute. Accordingly, barbed sutures do not have to be knotted, like conventional sutures. Like a conventional suture, a barbed suture may be inserted into tissue using a surgical needle.
- For instance, U.S. Pat. No. 3,123,077 to Alcamo describes an elongated cord for sewing human flesh, where the cord has a body portion and sharp-edged, resilient barbs projecting from the body at acute angles relative to the body. The barbed suture can be passed through tissue in one direction, but resists movement in the opposite direction.
- Sutures with barbs disposed in a bi-directional arrangement, also called double-armed sutures, are shown in U.S. Pat. No. 5,931,855 to Buncke and U.S. Pat. No. 6,241,747 to Ruff. More particularly, the suture has barbs facing toward one end of the suture for about half the suture length and barbs facing in the opposite direction toward the other end of the suture for the other half of the suture length. This arrangement allows the barbs to move in the same direction as each respective suture end is inserted into the first and second sides of a wound. Such bi-directional barbed sutures not only are especially suitable for closing wounds with edges prone to separation, but also obviate the need to secure suture ends together with knotted loops.
- Of interest is European Published Patent Application No. 1,075,843 A1 to Sulamanidze and Mikhailov, published Feb. 2, 2001, derived from PCT/RU99/00263 (published as WO 00/51658 on Sep. 8, 2000), priority to RU 99103732 (Mar. 3, 1999), which shows conical barbs arranged sequentially along the length of a thread and oriented in a direction opposite to that of the thread tension, with the distance between barbs being not less than 1.5 times the thread diameter.
- Also of interest is U.S. Pat. No.5,342,376 to Ruff. This patent shows an insertion device that is useful for positioning a barbed suture in order to close a wound. The insertion device has a tubular body for receiving a barbed suture, and preferably also has a handle to facilitate manipulation of the device by the surgeon. The insertion device is recommended for use with a barbed suture where the suture portion being inserted includes barbs facing a direction opposed to the direction of insertion. Such sutures with barbs opposing the direction of insertion are also shown in '376 to Ruff.
- The disclosures of all patents and patent applications mentioned here are incorporated by reference.
- Escarpment of barbs into a monofilament, depending on the barb cut depth, reduces the straight pull tensile strength since the effective suture diameter is decreased. However, the straight pull tensile strength of a barbed suture should be compared to the minimum knot pull strength of a conventional suture (a non-barbed suture) in accordance with the United States Pharmacopoeia since failure of conventional sutures (which have to be knotted and must meet a minimum knot pull tensile strength) occurs most frequently at the knot due to increased local stress.
- To optimize the performance of a barbed suture, it is advantageous to consider varying the barb geometry (barb cut angle, barb cut depth, barb cut length, barb cut distance, etc.) and/or the spatial arrangement of the barbs. This should not only enhance the tensile strength of a barbed suture, but also should enhance the ability of a barbed suture in holding and maintaining wound edges together. Unlike conventional sutures, which place tensions directly at the knots, barbed sutures can spread out the tension along the escarped suture length, often evenly along the length. Optimizing the disposition and/or the configuration of the barbs should therefore further increase the effectiveness of the new barbed suture in maximizing the holding strength and minimizing the gap formation along the wound edges. The latter is particularly beneficial for promoting wound healing.
- Also, such new barbed sutures should approximate tissue quickly with appropriate tension, alleviate distortion of tissue, and help to minimize scarring, due to the self-retaining benefits imparted by the barbs. The new barbed sutures would be especially useful in surgeries where minimization of scarring is imperative, such as cosmetic surgery, as well as in surgeries where space is limited, such as endoscopic surgery or microsurgery.
- Accordingly, the present invention provides a barbed suture for connecting human or animal tissue. The barbed suture comprises an elongated body having a first end and a second end. The barbed suture further comprises a plurality of barbs projecting from the body. Each barb is adapted for enabling the barbed suture to resist movement, when in tissue, in the direction that is opposite from the direction in which that barb faces. The barbed suture further comprises the barbs being disposed on the body in a disposition selected from a staggered disposition, a twist cut multiple spiral disposition, an overlapping disposition, a random disposition, or combinations thereof.
- For the staggered disposition, the twist cut multiple spiral disposition, and/or the overlapping disposition, the barbs may all be facing toward only one of the first and second ends. Alternatively, the barbed suture may have at least a first portion and a second portion, where the barbs of the first portion are facing toward the first end and the barbs of the second portion are facing toward the second end.
- Also, in an alternative embodiment, the present invention provides a barbed suture for connecting human or animal tissue, where the suture comprises an elongated body having a first end and a second end. The suture further comprises a plurality of barbs projecting from the body. Each barb is adapted for enabling the suture to resist movement, when the suture is in tissue, in the direction that is opposite from the direction in which that barb faces. The suture further comprises the barbs having a configuration selected from a barb cut angle θ ranging from about 140 degrees to about 175 degrees, a barb cut depth with a ratio of cut depth to suture diameter ranging from about 0.05 to about 0.6, a barb cut length with a ratio of cut length to suture diameter ranging from about 0.2 to about 2, a barb cut distance with a ratio of cut distance to suture diameter ranging from about 0.1 to about 6, a corrugated underside, an arcuate base, varying sizes, or combinations thereof.
- For the twist cut multiple spiral disposition, the barbed suture preferably has a spirality α angle ranging from about 5 degrees to about 25 degrees.
- For the overlapping disposition, it is meant that at least two adjacent barbs are disposed where one overlaps the other. During escarpment of the barbs, the overlapping is created by a barb (i.e., the overlapping barb) being escarped into the topside of another adjacent barb (i.e., the overlapped barb), and so on. Hence, part of the topside of the overlapped barb becomes part of the underside of the overlapping barb, and so on. Thus, with the overlapping disposition, the barb cut distance between the overlapping barb and the overlapped barb may be shorter than the barb cut length of overlapped second barb, whereas, in general for barbed sutures, the barb cut distance between two barbs ≧ the barb cut length.
- In still another embodiment, the present invention provides a barbed suture for connecting human or animal tissue in combination with a surgical needle, where the combination comprises a barbed suture attached to a surgical needle. The suture comprises a plurality of barbs projecting from an elongated body having a first end and a second end. Each barb is adapted for enabling the suture to resist movement, when the suture is in tissue, in the direction that is opposite from the direction in which that barb faces. The ratio of the surgical needle diameter to the suture diameter preferably is about 3:1 or less. Suitably, any of the inventive barbed sutures described here may be attached to a surgical needle.
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FIG. 1A is a side view of one embodiment of the present invention, showing a barbed suture with barbs disposed in a 180 degree staggered spacing; -
FIG. 1B is a sectional view alongline 1B-1B of the barbed suture inFIG. 1A ; -
FIG. 2A is a side view of another embodiment of the present invention, showing a barbed suture that is bi-directional with barbs disposed in a 180 degree staggered spacing; -
FIG. 2B is a sectional view alongline 2B-2B of the barbed suture inFIG. 2A ; -
FIG. 3A is a side view of another embodiment of the present invention, showing a barbed suture with barbs disposed in a 120 degree staggered spacing; -
FIG. 3B is a sectional view alongline 3B-3B of the barbed suture inFIG. 3A ; -
FIG. 4A is a side view of another embodiment of the present invention, showing a barbed suture that is bi-directional with barbs disposed in a 120 degree staggered spacing; -
FIG. 4B is a sectional view alongline 4B-4B of the barbed suture inFIG. 4A ; -
FIG. 5A is a side view of another embodiment of the present invention, showing a barbed suture with barbs disposed in a twist cut multiple spiral disposition; -
FIG. 5B is a sectional view alongline 5B-5B of the barbed suture inFIG. 5A ; -
FIG. 6A is a side view of another embodiment of the present invention, showing a barbed suture that is bi-directional with barbs disposed in a twist cut multiple spiral disposition; -
FIG. 6B is a sectional view alongline 6B-6B of the barbed suture inFIG. 6A ; -
FIG. 7A is a sectional side view of a barbed suture, which is bi-directional with barbs disposed in a twist cut multiple spiral disposition like the barbed suture inFIG. 6A , but illustrated in an enlarged section; -
FIG. 7B is the sectional side view as illustrated inFIG. 7A , but rotated and clamped to align the barbs for measurement of the cut distance between the barbs; -
FIG. 8 is a side view of another embodiment of the present invention, showing a barbed suture with barbs in a random disposition; -
FIG. 9 is a sectional side view of another embodiment of the present invention, showing a barbed suture having a barb with a corrugated or serrated underside; -
FIG. 10A is a sectional perspective view another embodiment of the present invention, showing a barbed suture having a barb with an arcuate base; -
FIG. 10B is a sectional top plan view of the barbed suture inFIG. 10A ; -
FIG. 10C is a cross-sectional view alongline 10C-10C ofFIG. 10B ; -
FIG. 10D is a cross-sectional view alongline 10D-10D ofFIG. 10B ; -
FIG. 11 is a sectional side view of another embodiment of the present invention, showing a barbed suture with barbs of various sizes; -
FIG. 12A is a sectional perspective view of another embodiment of the present invention, showing a barbed suture with barbs in an overlapping disposition; -
FIG. 12B is a perspective view of a portion of the overlapping barbs of the suture ofFIG. 12A ; -
FIG. 12C is a plan view of the portion of barbs ofFIG. 12B ; -
FIG. 12D is a side view alongline 12D-12D ofFIG. 12C ; and -
FIGS. 13A, 13B , 13C, and 13D show various surgical needles, where a barbed suture is attached to each surgical needle. -
FIGS. 14A, 14B , 14C, and 14D show various surgical needles, where a barbed suture is attached to each surgical needle by shrink wrapping. -
FIGS. 15A, 15B , 15C, and 15D show various surgical needles, where a barbed suture is attached to each surgical needle by channel wrapping. -
FIGS. 16A, 16B , 16C, and 16D show various surgical needles, where a barbed suture is attached to each surgical needle by eyelet threading. - As used here, the term “wound” means a surgical incision, cut, laceration, severed tissue or accidental wound in human or animal skin or other human or animal bodily tissue, or other condition in a human or animal where suturing, stapling, or the use of another tissue connecting device may be required.
- Also as used here, the term “tissue” includes, but is not limited to, tissues such as skin, fat, fascia, bone, muscle, organs, nerves, or blood vessels, or fibrous tissues such as tendons or ligaments.
- Moreover, the term “polymer” as used here generally includes, but is not limited to, homopolymers, copolymers (such as block, graft, random and alternating copolymers), terpolymers, et cetera, and blends and modifications thereof. Furthermore, the term “polymer” shall include all possible structures of the material. These structures include, but are not limited to, isotactic, syndiotactic, and random symmetries.
- Although the sutures are described below in a preferred embodiment with a circular cross section, the sutures could also have a non-circular cross sectional shape that could increase the surface area and facilitate the formation of the barbs. Other cross sectional shapes may include, but are not limited to, oval, triangle, square, parallelepiped, trapezoid, rhomboid, pentagon, hexagon, cruciform, and the like. Typically, barbs are cut into a polymeric filament that has been formed by extrusion using a die with a circular cross section, and thus, the cross section of the filament will be circular, as that is what results during such extrusion. However, extrusion dies can be custom made with any desired cross-sectional shape.
- Hence, the term “diameter” as used here is intended to mean the transverse length of the cross section, regardless of whether the cross section is circular or some other shape.
- Suitable diameters for the inventive sutures described below may range from about 0.001 mm to about 1 mm, and of course, the diameter may be from about 0.01 mm to about 0.9 mm, or from about 0.015 mm to about 0.8 mm. The typical diameter ranges from about 0.01 mm to about 0.5 mm. The length of the suture can vary depending on several factors such as the length and/or depth of the wound to be closed, the type of tissue to be joined, the location of the wound, and the like. Typical suture lengths range from about 1 cm to about 30 cm, more particularly from about 2 cm to about 22 cm.
- The terms “staggered” and “staggering” as used here in relation to the disposition of barbs on a suture are intended to mean that the suture has at least two sets of barbs that are offset with respect to each other, where the first set is aligned longitudinally on the suture and the second set is aligned longitudinally on the suture, but a plane perpendicular to the suture and cutting transversely through the suture and intersecting the base of a barb of the first set will not intersect the base of a barb of the second set.
- The barbs project from the exterior surface of the suture body on which the barbs are disposed. Depending on the intended end use of the barbed suture, barbs of different sizes may be employed. In general, larger barbs are more suitable for joining certain types of tissue such as fat tissue or soft tissue. On the other hand, smaller barbs are more suitable for joining other types of tissue, such as collagen dense tissue.
- As noted above, barbed sutures may be made from the same materials used for making conventional loop sutures. Any particular chosen material for the barbed suture depends on the strength and flexibility requirements.
- More specifically, barbed sutures may be formed from a bio-absorbable material that allows the suture to degrade and thus to be absorbed over time into the tissue as the wound heals. Generally, bio-absorbable materials are polymeric, and depending on the particular polymer selected, the degradation time in the wound ranges from about 1 month to over 24 months. The use of bio-absorbable materials eliminates the necessity of removing the sutures from the patient.
- Various bio-absorbable polymers include, but are not limited to, polydioxanone, polylactide, polyglycolide, polycaprolactone, and copolymers thereof. Commercially available examples are polydioxanone (sold as PDS II, a trade name used by Ethicon for selling surgical sutures), copolymer of about 67% glycolide and about 33% trimethylene carbonate (sold as MAXON®, a trademark registered to American Cyanamid for surgical sutures), and copolymer of about 75% glycolide and about 25% caprolactone (sold as MONOCRYL®, a trademark registered to Johnson &Johnson for sutures and suture needles). Barbed sutures made from such bio-absorbable materials are useful in a wide range of applications.
- Additionally, barbed sutures may be formed from a non-absorbable material, which may be a polymer. Such polymers include, but are not limited to, polypropylene, polyamide (also known as nylon), polyester (such as polyethylene terephthlate, abbreviated here as PET), polytetrafluoroethylene (such as expanded polytetrafluoroethylene, abbreviated here as ePTFE and sold by Gore as GOR-TEX®), polyether-ester (such as polybutester, which is the condensation polymerization of dimethyl terephthlate, polytetramethylene ether glycol, and 1,4-butanediol, and which is marketed by Davis & Geck and by U.S. Surgical, companies owned by Tyco, under the name NOVAFIL®, which is a trademark registered to American Cyanamid for surgical sutures), or polyurethane. Alternatively, the non-absorbable material may be metal (e.g., steel), metal alloys, natural fiber (e.g., silk, cotton, et cetera), and the like.
- Most of the barbed sutures discussed below are described as having their ends being pointed and formed of a material sufficiently stiff to allow for piercing tissue. It is contemplated that the ends of the barbed sutures may comprise a surgical needle. In this embodiment, the barbed suture is adapted for attachment, such as by swaging, channel wrapping, heat shrinking, or eyelet threading to the surgical needle for insertion into tissue.
- Attachment by swaging is well described and is typically accomplished by inserting the suture end into the surgical needle hole that is longitudinally disposed at one end of the surgical needle (usually the hole has been drilled longitudinally into one end of the needle), followed by crimping the resultant about the needle hole so that the suture is secured to the surgical needle for insertion into tissue. Also, some surgical needles with a longitudinal hole in one end are heat-shrinkable tubes that are heat shrunk after insertion of the suture in order to attach the suture to the surgical needle. Additionally, some surgical needles have a channel or trough at one end, and the suture is laid in the trough, followed by wrapping to secure the suture to the surgical needle. Surgical needles with a conventional eyelet type of hole transversely disposed in one end of the surgical needle could also be used, but are not preferred for barbed sutures. For the present invention, part of the discussion below regards surgical needles swaged with barbed sutures, but it is contemplated that any other suitable means of attaching needles can be employed.
- Attachment of sutures and surgical needles is described in U.S. Pat. No. 3,981,307 Borysko, U.S. Pat. No. 5,084,063 to Korthoff, U.S. Pat. No. 5,102,418 to Granger et al., U.S. Pat. No. 5,123,911 to Granger et al., U.S. Pat. No. 5,500,991 to Demarest et al., U.S. Pat. No. 5,722,991 to Colligan, U.S. Pat. No. 6,012,216 to Esteves et al., and U.S. Pat. No. 6,163,948 to Esteves et al. A method for the manufacture of surgical needles is described in U.S. Pat. No. 5,533,982 to Rizk et al. Further, it is noted that the surgical needle may be coated, the coating allowing for the needle of the inventive combination surgical needle/barbed suture to be inserted into tissue with less force than if the surgical needle were not coated. The coating may be a polymer, for instance, a silicone resin coating. For example, an improved siliconized surgical needle that requires significantly less force to effect tissue penetration than a standard siliconized surgical needle is described in U.S. Pat. No. 5,258,013 to Granger et al.
- The barbs are disposed in various arrangements on the body of the suture. The barbs may be formed using any suitable method, including injection molding, stamping, cutting, laser, and the like. With regard to cutting, in general, polymeric threads or filaments are purchased, and then the barbs are cut onto the filament body.
- The cutting may be manual, but that is labor intensive and not cost effective.
- A very suitable cutting machine is disclosed in U.S. patent application Ser. No. 09/943,733 to Genova et al., assignors to Quill Medical, filed Aug. 31, 2001, the disclosure of which is incorporated by reference. Such a cutting machine has a plurality of blades for escarpment of barbs onto a suture filament. A typical cutting machine for manufacturing barbed sutures utilizes a cutting bed, a vise, one or more blade assemblies, and sometimes a template or guide for the blades. The suture filament is placed in the bed and held by the vise, with the transverse direction of the blades generally disposed in the transverse direction of the suture filament, in order to cut a plurality of axially spaced barbs disposed on the exterior of a suture filament.
- With reference now to the drawings, where like reference numerals designate corresponding or similar elements throughout the several views, shown in
FIG. 1A is a side view of a barbed suture according to the present invention and generally designated at 1. -
Suture 1 includeselongated body 2 that is generally circular in cross section and that terminates in end 4. End 4 is illustrated in one embodiment as being pointed for penetrating tissue, but it is contemplated that end 4 may comprise a surgical needle (not shown) for insertion into tissue. (The other end is not shown.) Also,suture 1 includes plurality of closely spacedbarbs 7, 9 arranged in a staggered unidirectional disposition. More specifically, axially spaced barbs 7 are radially arranged about 180 degrees from and staggered with respect to axially spacedbarbs 9, withbarbs 7, 9 facing pointed end 4. First set of barbs 7 define a plane that is substantially coplanar with the plane defined by second set ofbarbs 9, and consequently,barbs 7, 9 define substantially the same one plane due to the radial 180 degree arrangement. -
FIG. 1B , which is a cross sectional view alongline 1B-1B ofsuture 1 inFIG. 1A , more clearly illustrates angle X, namely the radial 180 degree arrangement of barbs 7 with respect tobarbs 9. As also can be seen fromFIG. 1B , the stippling illustrates that first barb 7 of barbs 7 is closer to pointed end 4 (not shown inFIG. 1B ), and thus, seems to be larger than farther awayfirst barb 9 ofbarbs 9, due to the staggering. A transverse plane that is perpendicular to suturebody 2 and that intersects the base of one barb 7 of barbs 7 does not intersect the base of anybarb 9 ofbarbs 9. -
Suture 1 may be made with a cutting machine that produces two sets ofbarbs 7, 9, usually one set at a time, in a staggered position alongsuture 1, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al. - First set of barbs 7 is created by placing and holding a suture filament in the vise, and then, the set of blades, with a predetermined length, splices into the suture filament at an angle selected to create barbs 7 pointing in one direction toward pointed end 4. Second set of
barbs 9 is created similarly after offsetting the blades longitudinally (to create the staggering) approximately half of the longitudinal distance between two of barbs 7 and also rotating the suture filament about 180 degrees on the vise, which is equipped to accommodate first set of barbs 7 that are already cut. - Shown in
FIG. 2A issuture 10, which is another embodiment of the present invention and is likesuture 1, except thatsuture 10 is bi-directional.Suture 10 includes elongatedbody 12 that is generally circular in cross section.Elongated body 12 terminates in first and second pointed ends 14, 16 for penetrating tissue. Also, it is contemplated that one or both ends 14, 16 may comprise a surgical needle (not shown) for insertion into tissue. Also,suture 10 includes plurality of closely spacedbarbs - More specifically, plurality of axially spaced
barbs 17 are radially arranged about 180 degrees from and staggered with respect to plurality of axially spacedbarbs 19, withbarbs end 14 for a portion (about half of the length) ofsuture 10. Similarly, plurality of axially spacedbarbs 18 are radially arranged about 180 degrees from and staggered with respect to plurality of axially spacedbarbs 20, withbarbs end 16 for another portion (approximately the other half of the length) ofsuture 10. First set ofbarbs barbs barbs barbs barbs -
FIG. 2B is a cross sectional view alongline 2B-2B ofsuture 10 inFIG. 2A , more clearly illustrating angle X, namely the radial 180 degree arrangement. Due to the staggering,first barb 17 ofbarbs 17 is closer to pointed end 14 (not shown inFIG. 2B ), and thus, appears larger than farther awayfirst barb 19 ofbarbs 19, as is illustrated by the stippling. A transverse plane that is perpendicular to suturebody 12 and that intersects the base of onebarb 17 ofbarbs 17 does not intersect the base of anybarb 19 ofbarbs 19. Likewise, a transverse plane that is perpendicular to suturebody 12 and that intersects the base of onebarb 18 ofbarbs 18 does not intersect the base of anybarb 20 ofbarbs 20. -
Suture 10 may be made with the same cutting machine assuture 1, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al., except with the following change in blade direction. - For first set of
bi-directional barbs barbs 17 facing in one direction towardpointed end 14. Next, the blades are rotated 180 degrees so that they are now disposed in the opposite direction and over the uncut half of the length. The blades are then allowed to splice into the other half of the length of the suture filament with a second cutting action to createbarbs 18 facing in the opposite direction towardpointed end 16. - Next, the blades are offset longitudinally (to create the staggering) about half of the longitudinal distance between two of
barbs 17, and also the suture filament is rotated about 180 degrees on the vice, which is equipped to accommodate first set ofbi-directional barbs bi-directional barbs barbs 20 facing in one direction towardpointed end 16. The first cutting action is followed by rotating the blades longitudinally 180 degrees so that they are now disposed in the opposite direction and over the uncut half of the length. The blades are then allowed to splice into the other half of the length of the suture filament with a second cutting action to createbarbs 19 facing in the opposite direction towardpointed end 14. - In an alternative embodiment (not shown) for
bi-directional suture 10, the portion ofsuture 10 withbarbs pointed end 16 and the portion ofsuture 10 withbarbs pointed end 14. With this variation, the barbed suture would be inserted into tissue with an insertion device, such as that shown in the above-noted U.S. Pat. No. 5,342,376 to Ruff. Additionally, it is noted that, if desired, barbs may be escarped so that there may be two portions with barbs facing one end and one portion with barbs facing the other end, or two portions with barbs facing one end and two portions with barbs facing the other end, and so on (not shown), and thus, if a portion of barbs is not facing the suture end to which those barbs are adjacent, then, the barbed suture would be inserted into tissue with an insertion device. - An advantage of a barbed suture having a radial 180 degree arrangement with staggering is that the 180 degree spacing is readily fabricated on relatively small diameter filaments and the staggering improves anchoring performance. Thus, in thin and delicate tissue, where a smaller suture is desirable, the staggered 180 degree spacing generates effective anchoring performance.
- Turning now to
FIG. 3A , depicted is a side view of another embodiment of a suture according to the present invention, and generally designated atsuture 30.Suture 30 is likesuture 1 shown inFIG. 1A , except that the radial spacing forsuture 30 is 120 degrees instead of 180 degrees as is shown forsuture 1. - More particularly,
suture 30 includes elongatedbody 32 that is generally circular in cross section and that terminates inpointed end 34 for penetrating tissue. It is contemplated thatend 34 may comprise a surgical needle (not shown) so that the suture can be inserted into tissue. (The other end is not shown.) Additionally,suture 30 includes plurality of closely spacedbarbs pointed end 34. Hence, the disposition ofbarbs - Also, axial spaced
barbs 35 are radially arranged about 120 degrees from and staggered with respect to axially spacedbarbs 37, which are radially arranged about 120 degrees from and staggered with respect to axially spacedbarbs 39. Hence, axially spacedbarbs 39 are also arranged about 120 degrees from and staggered with respect to axially spacedbarbs 35. As a result of the radial 120 degree arrangement, first set ofbarbs 35 define substantially the same one plane; second set ofbarbs 37 define substantially another same one plane; and third set ofbarbs 39 define substantially still another same one plane. Thus,suture 30 hasbarbs -
FIG. 3B is a cross sectional view alongline 3B-3B ofsuture 30 inFIG. 3A and shows with more particularity angle Y, namely the radial 120 degree arrangement ofbarbs 35 with respect tobarbs 37,barbs 37 with respect tobarbs 39, andbarbs 39 with respect tobarbs 35. - As illustrated by the stippling,
first barb 35 ofbarbs 35, because of the staggering, is closer to pointed end 34 (not shown inFIG. 3B ), and thus, seems to be larger than farther awayfirst barb 37 ofbarbs 37. Also,first barb 37 ofbarbs 37, due to the staggering, is closer to pointed end 34 (not shown inFIG. 3B ), and thus, seems to be larger than even farther awayfirst barb 39 ofbarbs 39. A transverse plane that is perpendicular to suturebody 32 and that intersects the base of onebarb 35 ofbarbs 35 does not intersect the base of anybarb 37 ofbarbs 37. Likewise, a transverse plane that is perpendicular to suturebody 32 and that intersects the base of onebarb 37 ofbarbs 37 does not intersect the base of anybarb 39 ofbarbs 39. Similarly, a transverse plane that is perpendicular to suturebody 32 and that intersects the base of onebarb 39 ofbarbs 39 does not intersect the base of anybarb 35 ofbarbs 35. -
Suture 30 may be made with the same cutting machine assuture 1, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al. The cutting machine is now used to produce three sets ofbarbs suture 30. - First set of
barbs 35 is created by placing and holding a suture filament in the vise, followed by the blades, after having been adjusted to a predetermined length, splicing into the suture filament at an angle that is chosen to createbarbs 35 so that all are facing in the same direction towardpointed end 34. - Next, the blades are offset longitudinally (to create the staggering) approximately half of the longitudinal distance between two of
barbs 35. Also, the filament is rotated about 120 degrees on the vise, which is equipped to accommodate first set ofbarbs 35 that have already been cut, and then second set ofbarbs 37 is created in a similar manner. - Likewise, the blades are again offset longitudinally (to create the staggering) approximately half the longitudinal distance between two of
barbs 35, and also the suture filament is rotated about 120 degrees on the vise, which is equipped to accommodate both already cut first set ofbarbs 35 and already cut second set ofbarbs 37. Following the longitudinal movement and rotation, third set ofbarbs 39 is created in a similar manner. - Preferably, each successive barb is escarped at a position about 120 degrees around
suture body 32 from the preceding barb and does not overlap with any other barb. - With reference now to
FIG. 4A , illustrated issuture 40, another embodiment of the present invention.Suture 40 is similar tosuture 30, except thatsuture 40 is bi-directional.Suture 40 includes elongatedbody 42 that is generally circular in cross section and that terminates in first and second pointed ends 44, 46 for penetrating tissue. Also, it is contemplated that one or both ends 44, 46 may comprise a surgical needle (not shown) in order to be inserted into tissue.Suture 40 further includes plurality of closely spacedbarbs - For about half of the length of
suture 40, axially spacedbarbs 47 are circumferentially arranged about 120 degrees from and staggered with respect to axially spacedbarbs 49, which are radially arranged about 120 degrees from and staggered with respect to axially spacedbarbs 51. Consequently, axially spacedbarbs 51 are also arranged about 120 degrees from and staggered with respect to axially spacedbarbs 47. Thus, a portion ofsuture 40 has all ofbarbs pointed end 44. - For the other half of the length of
suture 40, axially spacedbarbs 48 are radially arranged about 120 degrees from and staggered with respect to axially spacedbarbs 50, which are radially arranged about 120 degrees from and staggered with respect to axially spacedbarbs 52. Consequently, axially spacedbarbs 52 are also arranged about 120 degrees from and staggered with respect to axially spacedbarbs 48. Thus, another portion ofsuture 40 has all ofbarbs pointed end 46. - As a result of the radial 120 degree arrangement, first set of
barbs barbs barbs -
FIG. 4B , which is a cross sectional view alongline 4B-4B ofsuture 40 inFIG. 4A , shows more clearly angle Y, namely the radial 120 arrangement with greater specificity. As illustrated by the stippling,first barb 47 ofbarbs 47, on account of the staggering, is closer to pointed end 44 (not shown inFIG. 4B ), and thus, appears larger than farther awayfirst barb 49 ofbarbs 49. Also because of the staggering,first barb 49 ofbarbs 49 is closer to pointed end 44 (not shown inFIG. 4B ), and thus, appears larger than even farther awayfirst barb 51 ofbarbs 51. - A transverse plane that is perpendicular to suture
body 42 and that intersects the base of onebarb 47 ofbarbs 47 does not intersect the base of anybarb 49 ofbarbs 49. Likewise, a transverse plane that is perpendicular to suturebody 32 and that intersects the base of onebarb 49 ofbarbs 49 does not intersect the base of anybarb 51 ofbarbs 51. Similarly, a transverse plane that is perpendicular to suturebody 42 and that intersects the base of onebarb 51 ofbarbs 51 does not intersect the base of anybarb 47 ofbarbs 47. Also, a transverse plane that is perpendicular to suturebody 42 and that intersects the base of onebarb 48 ofbarbs 48 does not intersect the base of anybarb 50 ofbarbs 50. Likewise, a transverse plane that is perpendicular to suturebody 32 and that intersects the base of onebarb 50 ofbarbs 50 does not intersect the base of anybarb 52 ofbarbs 52. Similarly, a transverse plane that is perpendicular to suturebody 42 and that intersects the base of onebarb 52 ofbarbs 52 does not intersect the base of anybarb 48 ofbarbs 48. -
Suture 40 may be made with the same cutting machine assuture 1, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al., except with the following change in blade direction. - For first set of
bi-directional barbs barbs 47 facing in one direction towardpointed end 44. Then, the blades are rotated 180 degrees so that they are now disposed in the opposite direction and over the uncut half of the length. The blades then are allowed to splice into the other half of the length of the suture filament with a second cutting action to createbarbs 48 facing in the opposite direction towardpointed end 46. - Next, the blades are offset longitudinally (to create the staggering) for about half the longitudinal distance between two of
barbs 47, and also the suture filament is rotated about 120 degrees on the vise, which is equipped to accommodate first set ofbi-directional barbs bi-directional barbs barbs 50 facing in one direction towardpointed end 46. The first cutting action is followed by rotating the blades 180 degrees so that they are now disposed in the opposite direction and over the uncut half of the suture filament. They then splice into the other half of the length of the suture filament with a second cutting action to createbarbs 49 facing in the opposite direction towardpointed end 44. - Then, the blades are again offset longitudinally (to create the staggering) for about half the longitudinal distance between two of
barbs 47. Additionally, the suture filament again is rotated about 120 degrees on the vise, which is equipped to accommodate already cut first set ofbi-directional barbs bi-directional barbs bi-directional barbs barbs 51 facing in one direction towardpointed end 44. The first cutting action is followed by rotating the blades 180 degrees so that they are now disposed in the opposite direction and over the uncut half of the suture filament. They next splice into the other half of the length of the suture filament with a second cutting action to createbarbs 52 facing in the opposite direction towardpointed end 46. - Preferably, each successive barb is escarped at a position about 120 degrees around
suture body 42 from the preceding barb and does not overlap with any other barb. - In an alternative embodiment (not shown) for
bi-directional suture 40, the portion ofsuture 40 havingbarbs pointed end 46 and the portion ofsuture 40 havingbarbs pointed end 44. With this variation, the barbed suture would be inserted into tissue with an insertion device, such as that shown in the above-noted U.S. Pat. No. 5,342,376 to Ruff. Additionally, it is noted that, if desired, barbs may be escarped so that there may be two portions with barbs facing one end and one portion with barbs facing the other end, or two portions with barbs facing one end and two portions with barbs facing the other end, and so on (not shown), and thus, if a portion of barbs is not facing the suture end that those barbs are adjacent, then, the barbed suture would be inserted into tissue with an insertion device. - An advantage of a barbed suture with a radial 120 degree arrangement is that the barbs exert force in three distinct planes that compliment each other, resulting in maximization of the retention force of the suture overall. As noted above, the staggering enhances anchoring performance.
- Turning now to
FIG. 5A , shown is another embodiment of the present invention, which is generally designated atsuture 60, with radial spacing that is in a twist cut multiple spiral.Suture 60 includes elongatedbody 62 of generally circular cross section.Elongated body 62 terminates inpointed end 64 for penetrating tissue. Also, it is contemplated thatend 64 may comprise a surgical needle (not shown) for insertion into tissue. Furthermore,suture 60 includes plurality of closely spacedbarbs 67 arranged in a twist cut multiple spiral pattern aroundbody 62 and facing in the same direction towardpointed end 64. -
FIG. 5B is a cross sectional view alongline 5B-5B ofsuture 60 inFIG. 5A . Due to the twist cut multiple spiral disposition, eachrespective barb 67 seems to be smaller and smaller as each is farther and farther away from pointed end 64 (not shown inFIG. 5B ), the illusion of size difference being illustrated by the stippling. -
Suture 60 may be constructed with a similar cutting machine as that used for makingsuture 1, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al. With a twist cutting method,barbs 67 may be produced in multiple spirals that preferably are created at the same time as the suture filament is held stationary, instead of being rotated, when the cutting takes place. - More particularly, a suture filament that is about 7 inches (about 178 mm) in length, is longitudinally twisted for a portion of the suture length, such as 39 times for a portion that is about 4.5 inches (about 114 mm) of the suture length. Thus, an end is secured, and the other end is grasped and rotated 360 degrees, 39 times, so the portion of the suture filament is twisted when the suture is then placed and held in the vise.
- Twisting preferably is performed 28 to 50 times, and may be performed more or less, such as 19 to 70 times. Suitably, twisting may be from about 2 to about 17 twists per inch, or about 3 to about 15 twists per inch, or about 5 to about 13 twists per inch (per inch being per 25.4 mm).
- Next, the blades, after having been adjusted to a predetermined length, simultaneously splice into the suture filament. The cutting action makes cuts to create
barbs 67 so that all are facing in the same direction towardpointed end 64. After twist cut multiple spiralbarbed suture 60 is released from the vice and untwisted,barbs 67 are disposed in multiple spirals onsuture 60. - Turning now to
FIG. 6A , shown is another embodiment of the present invention, which is generally designated atsuture 70.Suture 70 is of a twist cut multiple spiral disposition and thus is similar tosuture 60, except thatsuture 70 is bi-directional.Suture 70 includes elongatedbody 72 that is generally circular in cross section and that terminates in first and second pointed ends 74, 76 for penetrating tissue. It is contemplated that one or both ofends -
Suture 70 further includes plurality of closely spacedbarbs body 72.Barbs suture 70, with each end portion EP ofsuture 70 being barb-free. More particularly, plurality ofbarbs 77 are arranged in a multiple spiral pattern with allbarbs 77 facing towardpointed end 74 for a part (about half) of middle portion MP along the length ofsuture 70. Similarly, plurality ofbarbs 78 are arranged in a multiple spiral pattern with allbarbs 78 facing towardpointed end 76 for another part (the other approximate half) of middle potion MP along the length ofsuture 70. -
FIG. 6B is a cross sectional view alongline 6B-6B ofsuture 60 inFIG. 6A . Due to the multiple spiral configuration, eachrespective barb 77 seems to be smaller and smaller as each is farther and farther away from pointed end 74 (not shown inFIG. 6B ), as illustrated by the stippling. -
Suture 70 may be made with the same cutting machine assuture 60, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al., but with the following change in blade direction. Using the twist cutting method,barbs 77 may be produced in multiple spirals that preferably are created at the same time, and then after the direction change for the blades,barbs 78 may be produced in multiple spirals that preferably are created at the same time. Thus during the cutting, the suture filament is held stationary instead of being rotated. - More specifically, a section of about 4.5 inches (about 114 mm) in length of a suture filament is twisted, such as 39 times for a suture about 7 inches (about 178 mm) in length. Thus, an end is secured, and the other end is grasped and rotated 360 degrees, 39 times, so the twisted section of the suture filament has about 8⅔ twists per inch (per 25.4 mm) when the suture filament is then is placed and held in the vise.
- Twisting preferably is performed 28 to 50 times, and may be performed more or less, such as 19 to 70 times. Suitably, twisting may be from about 2 to about 17 twists per inch, or about 3 to about 15 twists per inch, or about 5 to about 13 twists per inch (per inch being per 25.4 mm).
- Next, the blades, after having been adjusted to a predetermined length, splice into approximately half of the approximately 3 inch (approximately 76 mm) length of middle portion MP of the approximately 4.5 inch (approximately 114 mm) twisted section of the suture filament in a first cutting action with the blades making cuts to create
barbs 77 so that all are facing in one direction towardpointed end 74. Depending on how many blades there are on the cutting machine and howmany barbs 77 are desired, there may be one cutting motion to cut allbarbs 77 simultaneously, or there may be repeated cutting motions until the desired number ofbarbs 77 are escarped into a portion of the suture filament. - Then, the blades are rotated 180 degrees so that they are now disposed in the opposite direction and over the other half of the approximately 3 inch (approximately 76 mm) length of middle portion MP of the approximately 4.5 inch (approximately 114 mm) twisted section of the suture filament. The blades are then allowed to splice into the other half in a second cutting action with the blades making cuts to create
barbs 78 so that all are facing in the opposite direction towardpointed end 76. Depending on how many blades there are on the cutting machine and howmany barbs 78 are desired, there may be one cutting motion to cut allbarbs 78 simultaneously, or there may be repeated cutting motions until the desired number ofbarbs 78 are escarped into a portion of the suture filament. - When twist cut multiple spiral
barbed suture 70 is released from the vise and untwisted, the first cuts and the second cuts result inbarbs suture 70, the two respective portions defining middle portion MP of about 3 inches (about 76 mm) in length. - More particularly, several twist cut multiple spiral, barbed sutures were manufactured from a monofilament having a diameter of about 0.018 inch (about 0.457 mm) and spun from polydioxanone (which is a synthetic absorbable suture material). A diameter of about 0.018 inch (about 0.457 mm) is slightly larger than the size 0 synthetic absorbable suture, which has a diameter range from about 0.35 mm to about 0.399 mm in accordance with the specifications of the United States Pharmacopoeia (USP).
- Each suture contained a total of 78 barbs introduced in two respective multiple spiral patterns around the circumference of the suture. Since the barbed suture was bi-directional, the barbs were divided into a left group with 39 barbs disposed on a first portion of the suture and a right group with 39 barbs on a second portion of the suture, each group opposing the direction of the other group from the approximate middle of the suture. The specific cutting machine employed had 13 blades. Thus, for each group of 39 barbs, there were 3 cutting motions (3×13=39), with the blades being offset with a guide for each of the 3 cutting motions.
- Each suture was about 7 inches (about 178 mm) long. The middle portion MP was about 3 inches (about 76 mm) long and contained the 78 barbs that were escarped into the suture filament. Extending beyond the 3 inch (76 mm) barbed middle portion MP were two unbarbed end portions EP of the suture that were each about 2 inches (about 51 mm) long. Depending on the suturing technique, one or both ends of the barbed suture may be sufficiently pointed and rigid for insertion into tissue, or may comprise a straight or curved surgical needle.
- The strength of the twist cut, 7 inch (178 mm) barbed sutures was tested by two methods. One method was a straight pull tensile strength test with a Universal Tester and the other method was an in vivo performance test with dogs.
- For the straight pull tensile strength measurement, testing was performed using a Test Resources Universal Tester, Model 200Q. The average reading of 10 repeated measurements made for each kind of suture was recorded for the barbed sutures and for the comparison unbarbed sutures.
- Comparison unbarbed sutures were polydioxanone monofilaments (a synthetic absorbable suture material) of various suture diameters of about 0.018 inch (about 0.457 mm), about 0.015 inch (about 0.381 mm), and about 0.0115 inch (about 0.292 mm), which are respectively slightly larger than the United States Pharmacopoeia sizes 0, 2-0, and 3-0 for synthetic absorbable sutures. In accordance with United States Pharmacopoeia specifications for synthetic absorbable sutures, size 0 has a diameter range of about 0.35 mm to about 0.399 mm; size 2-0 has a diameter range of about 0.30 mm to about 0.339 mm; and size 3-0 has a diameter range of about 0.20 mm to about 0.249 mm.
- Each barbed suture was gripped at each end by being held with cork gasket padding in two respective serrated jaws, whereas each unbarbed suture was gripped at each end by being wrapped around two respective capstan roller grips. Capstan rollers were used for holding the unbarbed sutures to avoid stress and distension.
- The portion of each suture specimen between the two gripped places was about 5 inches (about 126 mm) in length, which, in the case of barbed sutures, contained the entire 3 inches (76 mm) of the barbed middle portion.
- Each specimen was pulled longitudinally at a rate of about 10 inches (about 254 mm) per minute until breakage occurred. The peak load was recorded as the straight pull tensile strength.
- The results are summarized in Table 6A below, and the far right column denotes the USP knot pull test minimum requirements for conventional (unbarbed) sutures made from a synthetic absorbable material.
TABLE 6A (Tensile Strength) USP Minimum Straight Requirements Barbed or Suture Pull for Knot Unbarbed Size (pounds) Pull (pounds) Unbarbed 0 17.72 8.60 Unbarbed 2-0 11.86 5.91 Unbarbed 3-0 8.82 3.90 Barbed 0 7.03 not applicable - As can be seen, escarpment of barbs into the size 0 polydioxanone monofilament reduced the straight pull tensile strength by approximately 60% as compared to the conventional unbarbed size 0 polydioxanone monofilament (7.03 pounds=40% of 17.72 pounds).
- However, the straight pull tensile strength of 7.03 pounds at breakage for the size 0 polydioxanone barbed suture (which, due to the escarpment of the barbs, has an effective diameter that is smaller than the diameter of the conventional unbarbed size 0 polydioxanone suture) compared favorably with the minimum USP knot pull requirement of 8.60 pounds for the size 0 polydioxanone conventional unbarbed suture.
- Additional straight pull tensile strength tests were performed on additional size 0 polydioxanone barbed sutures, as discussed below in Tables 7K-7Z, in connection with
FIGS. 7A and 7B . - For the in vivo performance, 3 mongrel dogs, each about 14 kg, were used. On each dog, 7 incisions were made at the thorax (twice), thigh (twice), flank, ventral midline, and paramedian, each of the 7 incisions having 1, 2, or 3 closure sites. The length of each incision ranged from about 0.5 inch (about 12.5 mm) to about 4 inches (about 101 mm) and the depth of each incision was from the superficial dermis to the peritoneum.
- Using the barbed sutures (all made from size 0 polydioxanone monofilament), 24 of the sites were closed. For comparison, the remaining sites were closed with various diameter sizes of conventional unbarbed sutures (1 site with size 2-0 silk braided filament, 6 sites with size 2-0 nylon monofilament, and 7 sites with size 3-0 polydioxanone monofilament), which were knotted. All closing of sites was performed according to a randomized scheme.
- The dogs were monitored daily, and then subjected to euthanasia at 14 days. At the time of death, the incisions were evaluated macroscopically. With regard to various tissues, incision sizes, and locations on the dogs, all sites apposed with the size 0 polydioxanone barbed sutures stayed closed and appeared to be healing normally throughout the 14 day observation period. No dehiscence occurred.
- The site apposed with the conventional unbarbed silk sutures and the sites apposed with the conventional unbarbed polydioxanone sutures also healed will without complications. No dehiscence occurred.
- For the 6 topical skin sites closed with the size 2-0 nylon monofilament conventional unbarbed sutures, 3 sites exhibited partial or complete suture loss, apparently due to self-mutilation by the dogs. Knots in the conventional sutures possibly caused discomfort by creating localized pressure, and animals cannot understand that they should not manipulate the sutures. Thus, barbed sutures should help obviate the problem of an animal manipulating and pulling out the sutures.
- In summary, the in vivo performance of the size 0 polydioxanone barbed sutures was efficacious when compared to the size 2-0 silk braided filament unbarbed sutures, the size 2-0 nylon monofilament unbarbed sutures, and the size 3-0 polydioxanone monofilament unbarbed sutures.
- In an alternative embodiment (not shown) for bi-directional twist cut, multiple
spiral suture 70, the portion ofsuture 70 on which is disposedbarbs 77 may havebarbs 77 facing towardpointed end 76 and the portion ofsuture 70 on which is disposedbarbs 78 may havebarbs 78 facing towardpointed end 74. With this variation, the barbed suture would be inserted into tissue with an insertion device, such as that shown in the above-noted U.S. Pat. No. 5,342,376 to Ruff. Also if desired, it is noted that barbs may be escarped so that there may be 2 portions with barbs facing an end and 1 portion with barbs facing the other end, or 2 portions with barbs facing an end and 2 portions with barbs facing the other end, and so on (not shown), and thus, if a portion of barbs is not facing the suture end to which those barbs are adjacent, then, the barbed suture would be inserted into tissue with an insertion device. - An advantage of a barbed suture having a twist cut, multiple spiral disposition is that such a barbed suture affords better wound holding capability as compared to the 120 degree spaced barbed suture. The reason is that the twist cut, multiple spiral pattern results in groups of barbs that complement successive and preceding groups of barbs, which tends to provide improved anchoring when the suture is in tissue. This feature is especially useful for tissue such as fat tissue, which has fewer connective fibers compared with other types of tissues, so that greater suture retention force is desirable.
- With reference now to
FIG. 7A , shown is a sectional side view ofbarbed suture 80.Barbed suture 80 has plurality of closely spacedbarbs 81 onelongated suture body 82 of generally circular cross section. Eachbarb 81 hasbarb tip 85. Shown are suture longitudinal axis A, suture diameter SD, barb length L, barb cut depth D, barb cut angle θ, cut distance P, spirality angle α, cut-out depression CD, and tip T of cut-out depression CD. -
FIG. 7B is the sectional side view as illustrated inFIG. 7A , but rotated and clamped to align the barbs for measurement of the cut distance P betweenbarbs 81.Barbed suture 80 is a twist cut, multiple spiral, bi-directional barbed suture, likesuture 70 inFIG. 6A , but illustrated as an enlarged section in order to show more detail with respect to the configuration ofbarbs 81 vis-a-vis suture longitudinal axis A, suture diameter SD, barb length L, barb cut depth D, barb cut angle θ, cut distance P, spirality angle α, cut-out depression CD, and terminus T of cut-out depression CD. - More specifically, several twist cut, multiple spiral, barbed sutures were manufactured from monofilament spun from polydioxanone and having a diameter of about 0.018 inch (about 0.457 mm, which is slightly more than the USP requirement for a size 0 synthetic absorbable suture). Each suture contained 78 barbs introduced in 2 separate multiple spiral patterns around the circumference of the suture. Since the barbs were bi-directional, they were divided into a left group with 39 barbs and a right group with 39 barbs, each group opposing the direction of the other group from the approximate middle of the suture. Each suture was about 7 inches (about 178 mm) long. The middle portion was about 3 inches (about 76 mm) of the suture and contained the 78 barbs that were escarped into the suture filament. Extending beyond the 3 inch (76 mm) barbed middle portion toward each suture end were two unbarbed end portions of the suture filament that were each about 2 inches (about 51 mm) long. Depending on the stitching technique, one or both ends of the barbed suture may be sufficiently pointed and rigid for insertion into tissue, or may comprise a straight or curved needle.
- In order to characterize the configuration of
barbs 81, anOptem Zoom 100 custom microscope with both ring and back lighting was used together with a CCD brand video camera in order to measure selectedbarbs 81 at ×21.5 magnification from each of the left and right groups. - The average was calculated for 10 repeated measurements (5 from the left group of barbs and 5 from the right group of barbs on the same suture) that were made for each of cut angle θ and cut depth D. Barb cut angle θ was measured from the surface of the cut to the outer surface of
barbed suture 80. Barb cut depth D was measured along a perpendicular from the outer surface ofbarbed suture 80 toward longitudinal axis A ofbarbed suture 80. The measurements enabled cut length L to be calculated using the following formula.
L=D/{Sin (180-θ)} - Also, angle α of spirality was measured microscopically on various
barbed sutures 80 as follows. When the twisted suture filament is gripped by the vise during cutting ofbarbs 81, the vise leaves a very light mark designated as line M impressed on the suture filament. Thus, line M will be parallel to the longitudinal axis of the vise while the twisted suture filament is being held in the vise. If the vise does not leave a light mark on the suture filament, then line M can be determined in that it is parallel to a line connecting the two respective terminus T of the two successive cut-out depressions CD left insuture body 82 from the escarpment of twosuccessive barbs 81. After cutting ofbarbs 81, whenbarbed suture 80 is released from the vise and untwisted so thatsuture 80 lies free, then line M spirals onsuture body 82 aroundbarbed suture 80, forming angle α of spirality. - Specifically for measuring spirality angle α, the
Optem Zoom 100 custom microscope was set with ring lighting at 60 and back lighting at coarse 12 andfine 10. Also, imaging analysis system software was used. Spirality angle α was then measured between the outer surface of the barbed suture and line M. The average was calculated for 10 repeated measurements (5 from the left group of barbs and 5 from the right group of barbs on the same suture). - Then,
barbed suture 80 was mounted in a twisting device with one end ofsuture 80 clamped in a fixed position. The other end ofsuture 80 was rotated to insert twist untilbarbs 81 were aligned. Next onbarbed suture 80, longitudinal cut distance P between twoadjacent barbs 81 was measured microscopically between the two respective terminus T of the two successive cut-out depressions CD left insuture body 82 from the escarpment of twosuccessive barbs 81. The average was calculated for 10 repeated measurements (5 from the left group of barbs and 5 from the right group of barbs on the same suture). - The results are summarized in the following Tables 7A, 7B, 7C, and 7D.
TABLE 7A (size 0 barbed suture) Ratio of D, L, or P over Suture Diameter Measurement Units Left Right (0.457 mm) cut angle θ degrees 156 ± 2 157 ± 1 not applicable cut depth D mm 0.15 ± 0.02 0.16 ± 0.04 0.35 cut length L mm 0.36 ± 0.03 0.40 ± 0.10 0.87 cut distance P mm 0.90 ± 0.17 0.88 ± 0.15 1.92 -
TABLE 7B (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 151 1.642 not applicable cut depth D mm 0.215 0.027 0.47 cut length L mm 0.446 0.042 0.97 cut distance P mm 0.962 0.073 2.1 spirality angle α degrees 20.833 1.602 not applicable -
TABLE 7C (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 154 2.870 not applicable cut depth D mm 0.205 0.033 0.45 cut length L mm 0.469 0.044 1.03 cut distance P mm 0.975 0.103 2.13 spirality angle α degrees 19.333 1.506 not applicable -
TABLE 7D (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 155 2.390 not applicable cut depth D mm 0.186 0.026 0.41 cut length L mm 0.437 0.039 0.96 cut distance P mm 0.966 0.071 2.11 spirality angle α degrees 18.833 2.137 not applicable - Also, some additional measurements of angle α were performed on a few additional bi-directional twist cut, multiple spiral barbed sutures with a diameter of about 0.018 inch (about 0.457 mm, slightly more than the USP requirement for a size 0 synthetic absorbable suture). The mean average was 16.87 and the standard deviation was ±0.85.
- Additionally, measurements of barb cut angle θ, barb length L, barb cut depth D, and cut distance P were performed on 3 additional bi-directional twist cut, multiple spiral barbed sutures like
sutures 80, but having a diameter of about 0.0115 inch (about 0.292 mm, which is slightly more than the USP requirement for a size 3-0 synthetic absorbable suture), and measurements of spirality angle α were performed on 2 of these 3 additional barbed sutures. Also, measurements of barb cut angle θ, barb length L, barb cut depth D, cut distance P, and spirality angle α were performed on 3 additional bi-directional twist cut, multiple spiral barbed sutures likesutures 80, but with a diameter of about 0.015 inch (about 0.381 mm, which is slightly more than the USP requirement for a size 2-0 synthetic absorbable suture). The results are summarized in the following Tables 7E, 7F, 7G, 7H, 7I, and 7J.TABLE 7E (size 3-0 barbed suture) Ratio of D, L, or P over Suture Standard Diameter Measurement Units Average Deviation (0.292 mm) cut angle θ degrees 166 1.651 not applicable cut depth D mm 0.107 0.007 0.37 cut length L mm 0.443 0.042 1.52 cut distance P mm 0.956 0.079 3.27 spirality angle α degrees not not applicable not applicable tested -
TABLE 7F (size 3-0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.292 mm) cut angle θ degrees 164 2.055 not applicable cut depth D mm 0.106 0.006 0.36 cut length L mm 0.395 0.042 1.35 cut distance P mm 0.959 0.074 3.28 spirality angle α degrees 7.329 0.547 not applicable -
TABLE 7G (size 3-0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.292 mm) cut angle θ degrees 165 1.031 not applicable cut depth D mm 0.104 0.009 0.36 cut length L mm 0.390 0.035 1.34 cut distance P mm 0.975 0.103 3.34 spirality angle α degrees 7.258 0.636 not applicable -
TABLE 7H (size 2-0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.381 mm) cut angle θ degrees 160.2 1.320 not applicable cut depth D mm 0.152 0.019 0.40 cut length L mm 0.449 0.057 1.18 cut distance P mm 0.944 0.098 2.48 spirality angle α degrees 9.40 1.606 not applicable -
TABLE 7I (size 2-0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.381 mm) cut angle θ degrees 161.0 1.707 not applicable cut depth D mm 0.158 0.014 0.41 cut length L mm 0.489 0.054 1.28 cut distance P mm 0.962 0.054 2.52 spirality angle α degrees 7.96 1.075 not applicable -
TABLE 7J (size 2-0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.381 mm) cut angle θ degrees 161.0 1.506 not applicable cut depth D mm 0.154 0.017 0.40 cut length L mm 0.474 0.058 1.24 cut distance P mm 0.973 0.068 2.55 spirality angle α degrees 6.53 1.755 not applicable - Additional measurements were performed on several other twist cut, multiple spiral, barbed sutures manufactured from monofilament spun from polydioxanone and having a diameter of about 0.018 inch (about 0.457 mm, which is slightly more than the USP requirement for a size 0 synthetic absorbable suture) and thus similar to the above-described tested barbed sutures, except that these other barbed sutures were cut with a different cutting machine, namely a machine with one blade that moved longitudinally along the twisted filament between cutting strokes and that was controlled with a computer to make the various cuts for the escarpment of the barbs. These other barbed sutures were also tested for straight pull tensile strength and for chamois cloth closure strength. (A discussion of how chamois cloth closure strength is performed can be seen below in connection with
FIGS. 13A and 13B .) The results for these other barbed sutures are summarized in the following Tables 7K-7Z.TABLE 7K (size 0 barbed suture) Ratio of D, L, or P over Suture Standard Diameter Measurement Units Average Deviation (0.457 mm) cut angle θ degrees 152.6 0.718 not applicable cut depth D mm 0.221 0.011 0.48 cut length L mm 0.479 0.022 1.05 cut distance P mm 0.784 0.015 1.71 spirality angle α degrees 12.9 0.453 not applicable -
TABLE 7L (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 152.4 0.947 not applicable cut depth D mm 0.216 0.014 0.47 cut length L mm 0.465 0.024 1.02 cut distance P mm 0.774 0.015 1.69 spirality angle α degrees 13.2 0.349 not applicable -
TABLE 7M (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 152.3 0.576 not applicable cut depth D mm 0.227 0.015 0.50 cut length L mm 0.489 0.034 1.07 cut distance P mm 0.796 0.018 1.74 spirality angle α degrees 13.1 0.193 not applicable -
TABLE 7N (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 152.8 0.612 not applicable cut depth D mm 0.207 0.007 0.45 cut length L mm 0.453 0.016 0.99 cut distance P mm 0.798 0.017 1.75 spirality angle α degrees 13.6 0.560 not applicable -
TABLE 7O (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 152.9 0.549 not applicable cut depth D mm 0.188 0.016 0.41 cut length L mm 0.413 0.030 0.90 cut distance P mm 0.787 0.024 1.72 spirality angle α degrees 13.8 0.270 not applicable -
TABLE 7P (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 153.1 0.655 not applicable cut depth D mm 0.204 0.007 0.45 cut length L mm 0.451 0.019 0.99 cut distance P mm 0.792 0.018 1.73 spirality angle α degrees 13.6 0.410 not applicable -
TABLE 7Q (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 163.1 0.505 not applicable cut depth D mm 0.245 0.013 0.54 cut length L mm 0.842 0.045 1.84 cut distance P mm 0.774 0.009 1.69 spirality angle α degrees 10.8 0.449 not applicable -
TABLE 7R (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 161.1 1.126 not applicable cut depth D mm 0.233 0.017 0.51 cut length L mm 0.721 0.035 1.58 cut distance P mm 0.773 0.010 1.69 spirality angle α degrees 12.6 0.189 not applicable -
TABLE 7S (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 160.9 0.708 not applicable cut depth D mm 0.240 0.014 0.52 cut length L mm 0.734 0.037 1.61 cut distance P mm 0.774 0.009 1.69 spirality angle α degrees 13.6 0.312 not applicable -
TABLE 7T (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 154.6 1.434 not applicable cut depth D mm 0.210 0.009 0.46 cut length L mm 0.492 0.026 1.08 cut distance P mm 0.538 0.011 1.18 spirality angle α degrees 12.3 0.223 not applicable -
TABLE 7U (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 152.9 0.809 not applicable cut depth D mm 0.212 0.014 0.46 cut length L mm 0.464 0.026 1.01 cut distance P mm 0.530 0.015 1.16 spirality angle α degrees 13.7 0.411 not applicable -
TABLE 7V (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 153.4 0.903 not applicable cut depth D mm 0.221 0.010 0.48 cut length L mm 0.495 0.023 1.08 cut distance P mm 0.537 0.012 1.17 spirality angle α degrees 13.9 0.605 not applicable -
TABLE 7W (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 155.2 0.829 not applicable cut depth D mm 0.202 0.008 0.44 cut length L mm 0.483 0.017 1.06 cut distance P mm 0.789 0.031 1.73 spirality angle α degrees 12.6 0.328 not applicable -
TABLE 7X (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 155.5 0.799 not applicable cut depth D mm 0.200 0.010 0.44 cut length L mm 0.484 0.027 1.06 cut distance P mm 0.798 0.017 1.75 spirality angle α degrees 11.8 0.362 not applicable -
TABLE 7Y (size 0 barbed suture) Ratio of D, L, or Standard P over Suture Measurement Units Average Deviation Diameter (0.457 mm) cut angle θ degrees 155.4 0.560 not applicable cut depth D mm 0.196 0.008 0.43 cut length L mm 0.471 0.017 1.03 cut distance P mm 0.799 0.019 1.75 spirality angle α degrees 11.8 0.496 not applicable -
TABLE 7Z Chamois Cloth Straight Pull Closure Strength Barbed Suture Strength (pounds) (pounds to rupture) Sample 17.29 11.23 (Tables 7K-7M) Sample 28.73 12.14 (Tables 7N-7P) Sample 38.5 9.22 (Tables 7Q-7S) Sample 4 5.92 9.27 (Tables 7T-7V) Sample 5 7.69 9.97 (Tables 7W-7Y) - Although all the above-noted measurements were performed on bi-directional, twist cut, multiple spiral barbed sutures, the below-noted desirable ranges for measurements for barb length L, barb cut depth D, barb cut angle θ, and/or cut distance P should be the same for the various other inventive barbed sutures described here.
- A suitable ratio of cut length L to barbed suture diameter SD ranges from about 0.2 to about 2, more preferably from about 0.4 to about 1.7, even more preferably from about 0.8 to about 1.5. However, very suitable barbed sutures may have a ratio of cut length L to barbed suture diameter SD from about 1 down to about 0.2, whereby the ratio of the highest possible barb elevation (the elevation of
barb tip 85 above suture body 82) to the suture diameter SD correspondingly ranges from about 1 down to about 0.2. (The highest possible barb elevation is the same as the barb length L.) Also, a suitable ratio of cut depth D to barbed suture diameter SD ranges from about 0.05 to about 0.6, more preferably from about 0.1 to about 0.55, even more preferably from about 0.2 to about 0.5. - Regardless, length L may be desirably varied depending on the intended end use, since larger barbs are more suitable for joining certain types of tissue such as fat tissue or soft tissue, whereas smaller barbs are more suitable for joining other types of tissues such as fibrous tissue. As discussed in more detail below vis-a-vis
FIG. 11 , there will also be instances where a barb configuration that is a combination of large, medium, and/or small barbs disposed on the same suture will be desirable, for instance, when the barbed suture is employed in tissue that has differing layer structures. - Cut angle θ formed between the barb and the elongated suture body desirably would range from about 140 degrees to about 175 degrees, more preferably would range from about 145 degrees to about 173 degrees. The most preferred cut angle θ for all barbs ranges from about 150° to about 170°.
- For instance, for a polydioxanone barbed suture with a diameter of about 0.018 inch (about 0.457 mm), which is slightly larger that the USP requirement for a synthetic absorbable suture of size 0, the preferred barb length L would be 0.45 mm; the preferred barb depth D would be 0.2 mm; and the preferred barb cut angle would be 153 degrees.
- Longitudinal spacing between any two barbs is generally effected with the goal of creating as many barbs as possible along the suture, and is a factor in the ability of the barbed suture to anchor tissues while maintaining firmness. As barbs are spaced farther apart, tissue-anchoring capacity decreases. Nevertheless, if barbs are spaced too close, the integrity of the filament may be jeopardized, which could lead to a tendency of the barbs to peel back and also to a decrease in suture tensile strength.
- Generally, a suitable ratio of cut distance P to barbed suture diameter SD ranges from about 0.1 to about 6, more preferably from about 0.5 to about 4.5, even more preferably from about 1.0 to about 3.5. Very suitable barbed sutures may have a ratio of cut distance P to barbed suture diameter SD from about 1.5 down to about 0.2, whereby cut distance P may be as low as about 0.1, particularly for the overlapping barb embodiment, which is discussed in more detail below vis-à-vis
FIGS. 12A, 12B , 12C, and 12D. - Additionally, spirality angle α formed between line M and the longitudinal direction of the elongated suture body for a twist cut, multiple spiral barbed suture typically would range from about 5 degrees to about 25 degrees, more preferably from about 7 degrees to about 21 degrees. The most preferred angle α for all barbs on a twist cut, multiple spiral barbed suture is about 10° to about 18°.
- Turning now to
FIG. 8 , shown issuture 90, which is another embodiment of the present invention.Suture 90 includes elongatedbody 92 that is generally circular in cross section.Elongated body 92 terminates in first and second pointed ends 94, 96 for penetrating tissue. It is contemplated that one or both ends 94, 96 may comprise a surgical needle (not shown) for insertion into tissue. Additionally,suture 90 includes plurality of closely spacedbarbs 97 arranged in a random disposition. -
Suture 90 may be made with the same cutting machine as the above-discussed sutures, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al. With combinations of the above-described methods for making the 180 degree disposition (sutures 1, 10), the 120 degree disposition (sutures 30, 40), and/or the twist cut multiple spiral disposition (sutures 60, 70, 80),barbed suture 90 with a very random barb disposition is obtained. The advantage of the random disposition is that the many barb angles provide superior anchoring in tissues and thus afford superior wound holding properties. With the random disposition, the barbed suture would be inserted into tissue with an insertion device, such as that shown in the above-noted U.S. Pat. No. 5,342,376 to Ruff. - With regard to
FIG. 9 , shown is a sectional side view ofbarbed suture 100, which is another embodiment of the present invention.Suture 100 includeselongated suture body 102 of generally circular cross section. Also,suture body 102 has disposed on it a plurality of closely spacedbarbs 107. Eachbarb 107 has a barb configuration such thatbarb underside 108 is serrated or corrugated. One or both suture ends (not shown) are pointed for penetrating tissue and it is contemplated that one or both may comprise a surgical needle (not shown) for insertion into tissue. - Suture 100 may be made with the same cutting machine as the above-discussed sutures, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al.
Barb 107 havingserrated underside 108 is achieved by vibrating or oscillating the cutting blades of the cutting device when barbs are being escarped into the body of a monofilament. It is intended that any of the barbed sutures of the present invention as described here may have barbs with a configuration that includes a serrated or corrugated underside. - With reference now to
FIGS. 10A and 10B , depicted inFIG. 10A is a perspective view and depicted inFIG. 10B is a top view ofbarbed suture 110, which is another embodiment of the present invention.Suture 110 includeselongated suture body 112 of generally circular cross section. Also,suture body 112 has disposed on it a plurality of closely spacedbarbs 115 having barb tips 117 (onebarb 115 is shown for purposes of brevity).Barb 115 has a configuration with anarcuate base 119 wherebarb 115 is attached to suturebody 112. One or both suture ends (not shown) are pointed for penetrating tissue and it is contemplated that one or both may comprise a surgical needle (not shown) for insertion into tissue. -
FIGS. 10C and 10D are cross-sectional views respectively alongline 10C-10C andline 10D-10D ofFIG. 10B .FIG. 10C and 10D further clarify thatbarb 115 becomes narrower going frombase 119 towardtip 117. - Suture 110 may be made with the same cutting machine as the above-discussed sutures, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al. To achieve
barb 115 havingarcuate base 119, the cutting device is provided with cutting blades with ends that are correspondingly arcuate with respect toarcuate base 119. - It is intended that any of the barbed sutures of the present invention as described here may have barbs with a configuration that includes an arcuate base. The arcuate base should enhance tissue anchoring as compared to a flat, linear base. Regardless, it is not desired for the base to be circular or oval, which would result from conical shaped barbs, as that could decrease tissue anchoring.
- Shown in
FIG. 11 is a sectional side view of a barbed suture that is another embodiment of the present invention, and that is generally designated at 120.Suture 120 includeselongated body 122 that is generally circular in cross section.Elongated body 122 terminates inend 124.End 124 is pointed for penetrating tissue and it is contemplated thatend 124 may comprise a surgical needle (not shown) for insertion into tissue. (The other end is not shown, and also may be pointed for penetrating tissue and may comprise a surgical needle for penetrating tissue.) - Also,
suture 120 includes plurality of closely spacedbarbs 125, plurality of closely spacedbarbs 127, and plurality of closely spacedbarbs 129.Barbs 125 are relatively small in size with a relatively short barb length as compared tobarbs 127, which are relatively medium in size with a relatively medium barb length, as compared tobarbs 129, which are relatively large in size with a relatively long barb length. - Suture 120 may be made with the same cutting machine as the above-described sutures were made, such as the cutting device described in the above-noted Ser. No. 09/943,733 to Genova et al. By altering the amount of blade movement during cutting into a suture filament, then the barb cut length is made longer or shorter, as desired, to result in each of the three sets of
barbs - For instance, relatively larger barbs are desirable for joining fat and soft tissues, whereas relatively smaller barbs are desirable for joining fibrous tissues. Use of a combination of large, medium, and/or small barbs on the same suture helps to ensure maximum anchoring properties when barb sizes are customized for each tissue layer. Only two different sized sets of barbs (not shown) may be escarped into
suture body 122, or additional sets of barbs (not shown) with four, five, six, or more different sized sets than three sizes as illustrated for sets ofbarbs suture body 122 as desired, in accordance with the intended end use. Also, althoughsuture 120 is illustrated with the barbs being unidirectional, it is intended that barbed sutures with barbs having a configuration of varying sizes in accordance with the invention also may be bi-directional barbed sutures or random barbed sutures or any of the other inventive barbed sutures described here. -
FIG. 12A is a perspective view of another embodiment of the present invention, showingbarbed suture 130 having elongatedbody 132 of generally circular cross section. One or both suture ends (not shown) are pointed for penetrating tissue and it is contemplated that one or both ends may comprise a surgical needle (not shown) for insertion into tissue. - Suture 130 further includes plurality of
barbs 135 projecting frombody 132 such that at least two longitudinally adjacent first andsecond barbs 135 are disposed onbody 132 wherefirst barb 135 overlapssecond barb 135 if first andsecond barbs 135, which is readily apparent ifbarbs 135 are laid flat onbody 132. -
FIG. 12B is a perspective view of a portion of overlappingbarbs 135 of the overlapping dispositionbarbed suture 130 ofFIG. 12A , andFIG. 12C is a top plan view ofFIG. 12B .FIG. 12D is a cross-sectional view alongling 12D-12D ofFIG. 12C . As can be more clearly seen fromFIGS. 12B, 12C , and 12D, during escarpment ofbarbs 135, overlappingfirst barb 135 is escarped into part of topside TS of overlappedsecond barb 135, and so on. Part of topside TS of overlappedsecond barb 135 becomes part of underside US of overlappingfirst barb 135. - Thus, with the overlapping disposition, the barb cut distance between
first barb 135 andsecond barb 135 may be shorter than the barb cut length of overlappedsecond barb 135, whereas, in general for barbed sutures, the barb cut distance between two barbs ≧ the barb cut length. Particularly for the overlapping barb disposition, very suitable barbed sutures may have a ratio of the barb cut distance to the barbed suture diameter from about 1.5 down to about 0.2, since the barb cut distance P may be as low as about 0.1. (See discussion ofFIG. 7 for comments vis-à-vis the barb cut length and the barb cut distance.) This overlapping disposition allows for closely packingmany barbs 135 onbody 132, and typically,barbs 135 are thin, as compared to when the barb cut distance between two barbs ≧ the barb cut length. - Also, although
suture 130 is illustrated withbarbs 135 being unidirectional, it is intended to include thatsuture 130 in accordance with the invention also may be a bi-directional barbed suture as described here. -
FIGS. 13A, 13B , 13C, 13D. 14A, 14B, 14C, 14D, 15A, 15B, 15C, 15D, 16A, 16B, 16C, and 16D show various surgical needles, where a barbed suture is attached to each surgical needle. In order to facilitate insertion into tissue, the surgical needles may be coated with a polymer, for instance, as described above vis-à-vis U.S. Pat. No. 5,258,013 to Granger et al. -
FIG. 13A shows surgical needle N1 that is a straight elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N1 has pointed tip T1 for insertion into tissue and also has hole H1. Surgical needle N1 is illustrated as attached, such as by swaging, to barbed suture S1. Barbed suture S1 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N1 has diameter D1 in the transverse direction, which is illustrated as a relatively thin diameter, such as about 0.02 inch (about 0.51 mm). As discussed above vis-a-vis swaging, surgical needle N1, after having suture S1 inserted into hole H1, may be crimped by standard procedures about hole H1 to hold suture S1 in place for suturing tissue. -
FIG. 13B shows surgical needle N2 that is a straight elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N2 has pointed tip T2 for insertion into tissue and also has hole H2. Surgical needle N2 is illustrated as attached, such as by swaging, to barbed suture S2. Barbed suture S2 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N2 has diameter D2 in the transverse direction, which is illustrated as a suitably thin diameter, such as about 0.032 inch (about 0.81 mm), but not as thin as diameter D1 of surgical needle N1. As discussed above vis-à-vis swaging, surgical needle N2, after having suture S2 inserted into hole H2, may be crimped by standard procedures about hole H2 to hold suture S2 in place for use in suturing tissue. -
FIG. 13C shows surgical needle N3 that is a curved elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N3 has pointed tip T3 for insertion into tissue and also has hole H3. Surgical needle N3 is illustrated as attached, such as by swaging, to barbed suture S3. Barbed suture S3 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N3 has diameter D3 in the transverse direction, which is illustrated as a relatively thin diameter, such as about 0.02 inch (about 0.51 mm). As discussed above vis-à-vis swaging, surgical needle N3, after having suture S3 inserted into hole H3, may be crimped by standard procedures about hole H3 to hold suture S3 in place for use in suturing tissue. -
FIG. 13D shows surgical needle N4 that is a curved elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N4 has pointed tip T4 for insertion into tissue and also has hole H4. Surgical needle N4 is illustrated as attached, such as by swaging, to barbed suture S4. Barbed suture S4 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N4 has diameter D4 in the transverse direction, which is illustrated as a suitably thin diameter, such as about 0.032 inch (about 0.81 mm), but not as thin as diameter D3 of surgical needle N3. As discussed above vis-à-vis swaging, surgical needle N4, after having suture S4 inserted into hole H4, may be crimped by standard procedures about hole H4 to hold suture S4 in place for use in suturing tissue. -
FIG. 14A shows surgical needle N1 that is a straight elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N1 has pointed tip T1 for insertion into tissue and also has hole H1. Barbed suture S1 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N1 has diameter D1 in the transverse direction, which is illustrated as a relatively thin diameter, such as about 0.02 inch (about 0.51 mm). Surgical needle N1 is illustrated as attached by shrink wrapping SW1 to barbed suture S1. More particularly, surgical needle N1, after having suture S1 inserted into hole H1, is shown having shrink wrapping SW1, illustrated in cutaway and disposed about needle/suture N1/S1, where the end of suture S1 is disposed in hole H1 at the end of needle N1, in order to hold suture S1 in place for suturing tissue. Surgical needle S1 may be crimped by standard procedures about hole H1 to help hold suture S1 in place. -
FIG. 14B shows surgical needle N2 that is a straight elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N2 has pointed tip T2 for insertion into tissue and also has hole H2. Barbed suture S2 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N2 has diameter D2 in the transverse direction, which is illustrated as a suitably thin diameter, such as about 0.032 inch (about 0.81 mm), but not as thin as diameter D1 of surgical needle N1. Surgical needle N2 is illustrated as attached by shrink wrapping SW2 to barbed suture S2. More particularly, surgical needle N2, after having suture S2 inserted into hole H2, is shown having shrink wrapping SW2, illustrated in cutaway and disposed about needle/suture N2/S2, where the end of suture S2 is disposed in hole H2 at the end of needle N2, in order to hold suture S2 in place for suturing tissue. Surgical needle S2 may be crimped by standard procedures about hole H2 to help hold suture S2 in place. -
FIG. 14C shows surgical needle N3 that is a curved elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N3 has pointed tip T3 for insertion into tissue and also has hole H3. Barbed suture S3 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N3 has diameter D3 in the transverse direction, which is illustrated as a relatively thin diameter, such as about 0.02 inch (about 0.51 mm). Surgical needle N3 is illustrated as attached by shrink wrapping SW3 to barbed suture S3. More particularly, surgical needle N3, after having suture S3 inserted into hole H3, is shown having shrink wrapping SW3, illustrated in cutaway and disposed about needle/suture N3/S3, where the end of suture S3 is disposed in hole H3, at the end of needle N3, in order to hold suture S3 in place for suturing tissue. Surgical needle S3 may be crimped by standard procedures about hole H3 to help hold suture S3 in place. -
FIG. 14D shows surgical needle N4 that is a curved elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N4 has pointed tip T4 for insertion into tissue and also has hole H4. Barbed suture S4 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N4 has diameter D4 in the transverse direction, which is illustrated as a suitably thin diameter, such as about 0.032 inch (about 0.81 mm), but not as thin as diameter D3 of surgical needle N3. Surgical needle N4 is illustrated as attached by shrink wrapping SW4 to barbed suture S4. More particularly, surgical needle N4, after having suture S4 inserted into hole H4, is shown having shrink wrapping SW4, illustrated in cutaway and disposed about needle/suture N4/S4, where the end of suture S4 is disposed in hole H4, at the end of needle N4, in order to hold suture S4 in place for suturing tissue. Surgical needle S4 may be crimped by standard procedures about hole H4 to help hold suture S4 in place. -
FIG. 15A shows surgical needle N1 that is a straight elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N1 has pointed tip T1 for insertion into tissue and also has channel C1. Barbed suture S1 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N1 has diameter D1 in the transverse direction, which is illustrated as a relatively thin diameter, such as about 0.02 inch (about 0.51 mm). Surgical needle N1 is illustrated as attached by channel wrapping CW1 to barbed suture S1. More particularly, surgical needle N1, after having suture S1 placed into channel C1, is shown having channel wrapping CW1, illustrated in cutaway and disposed about needle/suture N1/S1, where the end of suture S1 is disposed in channel C1 at the end of the needle N1, in order to hold suture S1 in place for suturing tissue. Surgical needle S1 may be crimped by standard procedures about channel C1 to help hold suture S1 in place. -
FIG. 15B shows surgical needle N2 that is a straight elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N2 has pointed tip T2 for insertion into tissue and also has channel C2. Barbed suture S2 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N2 has diameter D2 in the transverse direction, which is illustrated as a suitably thin diameter, such as about 0.032 inch (about 0.81 mm), but not as thin as diameter D1 of surgical needle N1. Surgical needle N2 is illustrated as attached by channel wrapping CW2 to barbed suture S2. More particularly, surgical needle N1, after having suture S2 placed into channel C2, is shown having channel wrapping CW2, illustrated in cutaway and disposed about needle/suture N2/S2, where the end of suture S2 is disposed in channel C2 at the end of the needle N2, in order to hold suture S2 in place for suturing tissue. Surgical needle S2 may be crimped by standard procedures about channel C2 to help hold suture S2 in place. -
FIG. 15C shows surgical needle N3 that is a curved elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N3 has pointed tip T3 for insertion into tissue and also has channel C3. Barbed suture S3 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N3 has diameter D3 in the transverse direction, which is illustrated as a relatively thin diameter, such as about 0.02 inch (about 0.51 mm). Surgical needle N3 is illustrated as attached by channel wrapping CW3 to barbed suture S3. More particularly, surgical needle N3, after having suture S3 placed into channel C3, is shown having channel wrapping CW3, illustrated in cutaway and disposed about needle/suture N3/S3, where the end of suture S3 is disposed in channel C3, at the end of needle N3, in order to hold suture S3 in place for suturing tissue. Surgical needle S3 may be crimped by standard procedures about channel C3 to help hold suture S3 in place. -
FIG. 15D shows surgical needle N4 that is a curved elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N4 has pointed tip T4 for insertion into tissue and also has channel C4. Barbed suture S4 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N4 has diameter D4 in the transverse direction, which is illustrated as a suitably thin diameter, such as about 0.032 inch (about 0.81 mm), but not as thin as diameter D3 of surgical needle N3. Surgical needle N4 is illustrated as attached by channel wrapping CW4 to barbed suture S4. More particularly, surgical needle N4, after having suture S4 placed into channel C4, is shown having channel wrapping CW4, illustrated in cutaway and disposed about needle/suture N4/S4, where the end of suture S4 is disposed in channel C4, at the end of needle N4, in order to hold suture S4 in place for suturing tissue. Surgical needle S4 may be crimped by standard procedures about channel C4 to help hold suture S4 in place. -
FIG. 16A shows surgical needle N1 that is a straight elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N1 has pointed tip T1 for insertion into tissue and also has eyelet E1. Barbed suture S1 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N1 has diameter D1 in the transverse direction, which is illustrated as a relatively thin diameter, such as about 0.02 inch (about 0.51 mm). Surgical needle N1 is illustrated as attached by eyelet threading to barbed suture S1. More particularly, surgical needle N1 is shown having suture S1 placed through eyelet E1, where the end of suture S1 is disposed in eyelet E1 at the end of the needle N1. In order to help hold suture S1 in place for suturing tissue, suture S1 may be looped more than once by standard procedures through eyelet E1 or suture S1 may be knotted by standard procedures. -
FIG. 16B shows surgical needle N2 that is a straight elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N2 has pointed tip T2 for insertion into tissue and also has eyelet E2. Barbed suture S2 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N2 has diameter D2 in the transverse direction, which is illustrated as a suitably thin diameter, such as about 0.032 inch (about 0.81 mm), but not as thin as diameter D1 of surgical needle N1. Surgical needle N2 is illustrated as attached by eyelet threading to barbed suture S2. More particularly, surgical needle N2 is shown having suture S2 placed through eyelet E2, where the end of suture S2 is disposed in eyelet E2 at the end of the needle N2. In order to help hold suture S2 in place for suturing tissue, suture S2 may be looped more than once by standard procedures through eyelet E2 or suture S1 may be knotted by standard procedures. -
FIG. 16C shows surgical needle N3 that is a curved elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N3 has pointed tip T3 for insertion into tissue and also has eyelet E3. Barbed suture S3 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N3 has diameter D3 in the transverse direction, which is illustrated as a relatively thin diameter, such as about 0.02 inch (about 0.51 mm). Surgical needle N3 is illustrated as attached by eyelet threading to barbed suture S3. More particularly, surgical needle N3 is shown having suture S3 placed through eyelet E3, where the end of suture S3 is disposed in eyelet E3, at the end of needle N3. In order to help hold suture S3 in place for suturing tissue, suture S3 may be looped more than once by standard procedures through eyelet E3 or suture S3 may be knotted. -
FIG. 16D shows surgical needle N4 that is a curved elongated needle in the longitudinal direction and that is generally circular in cross section. Surgical needle N4 has pointed tip T4 for insertion into tissue and also has eyelet E4. Barbed suture S4 is a barbed suture including, but not limited to, any of the above-described barbed sutures. Additionally, surgical needle N4 has diameter D4 in the transverse direction, which is illustrated as a suitably thin diameter, such as about 0.032 inch (about 0.81 mm), but not as thin as diameter D3 of surgical needle N3. Surgical needle N4 is illustrated as attached by eyelet threading to barbed suture S4. More particularly, surgical needle N4 is shown having suture S4 placed through eyelet E4, at the end of needle N4. In order to help hold suture S4 in place for suturing tissue, suture S4 may be looped more than once by standard procedures through eyelet E4 or suture S4 may be knotted by standard procedures. - Needle tips T1, T2, T3, and T4 are schematically illustrated as pointed, but, as is well known, surgical needles come with various kinds of pointed tips, such as taper point, taper cutting, ball point, cutting edge, diamond point, thin line, and lancet point, and it is intended to include, but not be limited to, all such needle tips. Taper point, taper cutting, and diamond point are preferred needle tips for surgical needles used with barbed sutures.
- As is well known in the art, needle diameter for surgical needles used with conventional (i.e., unbarbed) sutures is considered unimportant, and often very thick surgical needles are used with thin conventional sutures such that the ratio of surgical needle diameter to conventional suture diameter is 4:1 or even higher, such as 4.43:1.
- However, with the surgical needle/barbed suture combination of the present invention (for either a straight needle or a curved needle), the thinner that the surgical needle is, then the more preferable that the surgical needle/barbed suture is, with the desired needle diameter being thinner and thinner as it approaches the barbed suture diameter, and it is possible that the needle diameter may be even thinner than the barbed suture diameter.
- In general for the present invention, a relatively thin surgical needle attached to a barbed suture is more preferable for approximating tissue when stitching a wound closed than a relatively thick surgical needle threaded with a barbed suture. The reason is that the relatively thin surgical needle attached to a barbed suture allows for greater engagement of barbs in tissue, and therefore provides better closure strength to the approximated tissue that has been sutured to prevent the opposing sides of the closed wound from pulling apart, as compared to the closure strength provided to approximated tissue that has been sutured with the relatively thick surgical needle.
- The most important feature for the combination of the surgical needle attached to the barbed suture is that the surgical needle diameter should be of sufficient width in order to make a hole or a channel in the end, such by drilling, to allow for insertion of the barbed suture into the hole or the channel. Nevertheless, as the surgical needle diameter increases, the surgical needle is still suitable as long as the ratio of the surgical needle diameter to the barbed suture diameter is about 3:1 or less.
- Accordingly, a desirable ratio of surgical needle diameter to barbed suture diameter, for either a straight needle or a curved needle, is about 3:1 or less, more preferably about 2:1 or less, most preferably about 1.8:1 or less. Furthermore, particularly if channel needles are employed, the ratio of surgical needle diameter to barbed suture diameter may be as low as about 1:1 or less, or even lower, for instance, about 0.9:1 or less, or about 08:1 or less, or as low as about 0.5:1. It will be appreciated by the person of ordinary skill in the art that care should be taken with extremely thin needles so as to ameliorate the possibility of localized weakness, which may compromise tissue insertion.
- Closure strength of thin surgical needles, both having a ratio of surgical needle diameter to barbed suture diameter suitable for the present invention, was tested as follows.
- Various pieces of chamois leather (manufactured by U.S. Chamois of Florida) having a thickness of about 0.6 in (about 15.2 mm) were cut with a wound having a length of about 1.25 inch (about 32 mm).
- A first specimen was made from a piece of chamois leather by stitching together the respective edges of the wound with a drilled end surgical needle (item no. 382077A purchased from Sulzle Company) which was swaged with a barbed suture. In other words, after insertion of the barbed suture into the needle hole, the needle was crimped about the hole to secure the barbed suture during stitching. After stitching closed the wound, the piece of chamois leather was cut to a rectangular shape of about 3 inches (about 76 mm) in length by about 1.25 inches (about 32 mm) in width, where the stitched wound was in the middle of the length and transverse the width. The needle was a taper point, curved surgical needle (⅜ of a circle), with a length of about 22 mm and a relatively thin diameter of about 0.020 inch (about 0.51 mm).
- Then, using the same stitching method, a second specimen was made from another piece of chamois leather by stitching together the respective edges of the wound, using a drilled end surgical needle (item no. 383271A purchased from Sulzle Company) swaged with the same kind of barbed suture, i.e., the surgical needle was crimped about the needle hole, after insertion of the barbed suture into the hole, to secure the barbed suture during stitching. For the second specimen, the needle was a taper point curved surgical needle (⅜ of a circle) with a length of about 22 mm and a suitable thin diameter of about 0.032 inch (about 0.81 mm), although not as thin as the diameter of the needle used for first specimen.
- Each barbed suture for each specimen was a bi-directional, twist cut multiple spiral, polydioxanone barbed suture like
suture 70 inFIG. 6A , except that each barbed suture had a diameter of about 0.0115 inch (about 0.291 mm, which is slightly larger than the USP requirement for a size 3-0 synthetic absorbable suture), instead of a suture diameter of about 0.018 inch (about 0.457 mm). - Both the first and the second specimens of stitched chamois cloth were tested for closure strength using a Test Resources Universal Tester, Model 200Q. Each specimen was gripped by two respective serrated jaws. Then, each specimen was pulled longitudinally at a rate of about 10 inches per minute (about 254 mm per minute) until complete rupture. The peak load in pounds reached before complete wound disruption was recorded as the closure strength. The results were that the first specimen (which was sutured with the needle that had a relatively thin diameter of about 0.020 inch, about 0.51 mm) took 5.88 pounds until wound disruption occurred and the specimen pulled apart back into 2 pieces, whereas the second specimen (which was stitched with the needle that had a suitably thin diameter of about 0.032 inch, about 0.81 mm, but not as thin as the needle for the first specimen) took only 2.88 pounds until the wound disruption and the specimen pulled apart back into 2 pieces.
- The results are summarized in Table 13A below.
TABLE 13A (Chamois Cloth Closure Strength) Needle Barbed Suture Pounds to Specimen Diameter Diameter Ratio* Rupture First 0.020 inch 0.0115 inch 1.74 5.88 Second 0.032 inch 0.0115 inch 2.78 2.88
*Ratio of surgical needle diameter to barbed suture diameter.
- Also, various pieces of rat skin were cut and stitched for testing of more surgical needles swaged with barbed sutures as follows.
- Three freshly killed Sprague-Dawley rats, each about 600 to 700 g, were used. Two full-thickness skin incisions were made on the back of each rat to create wounds. Each wound was about 4 cm in length and parallel to the spine.
- For each rat, one of the two wounds was closed with a drilled end, curved surgical needle that was a Sulzle item no. 382273A, which was ⅜ circle. The needle had a length of 18 mm and a diameter of about 0.022 inch (about 0.56 mm). Also, the needle had a taper point needle tip where the needle tip had been ground to a 3-facet cut to approximate a taper cutting needle tip to facilitate penetration of rat tissue. The needle was swaged to a barbed suture.
- The other of the two wounds was closed using the same suturing technique, but with a drilled end, curved surgical needle that was a Sulzle item no. 832679A, which was ⅜ circle. The needle had a length of about 18 mm and a diameter of about 0.026 inch (about 0.66 mm). Also, the needle had a diamond point needle tip. The needle was swaged to a barbed suture.
- Each barbed suture for each specimen was a bi-directional, twist cut multiple spiral, polydioxanone barbed suture like
suture 70 inFIG. 6A , except that each barbed suture had a diameter of about 0.015 inch (about 0.381 mm, which is slightly larger than the USP requirement for a size 2-0 synthetic absorbable suture), instead of a suture diameter of about 0.018 inch (about 0.457 mm). - For each stitched wound, a tissue specimen that was approximately a square measuring about 4 cm×about 4 cm, with the stitched wound in the middle paralleling two opposing tissue edges, was retrieved for closure strength testing.
- The force to open each wound was determined using a Test Resources Universal Tester, Model 200Q. For each tissue specimen, the two edges paralleling each stitched wound were mounted in the two respective serrated jaws of the tester.
- Then, each specimen was pulled longitudinally at a rate of about 2 inches per minute (about 51 mm per minute) until complete rupture occurred. The maximum force encountered before complete wound disruption was recorded as the closure strength.
- The results were averaged from the first set of three wounds closed with a needle having a diameter of about 0.022 inch (about 0.56 mm) and swaged to a barbed suture. Also, the results were averaged from the second set of three wounds closed with a needle having a diameter of about 0.026 inch (about 0.66 mm) and swaged to a barbed suture.
- The results are summarized in Table 13B below.
TABLE 13B (Rat Skin Closure Strength) Average of 3 Needle Barbed Suture Wounds Specimens Diameter Diameter Ratio* Pounds to Rupture First set of 3 0.022 inch 0.015 inch 1.47 11.9 Second set 0.026 inch 0.015 inch 1.73 8.1 of 3
*Ratio of surgical needle diameter to barbed suture diameter.
- Thus, the lower the ratio of surgical needle diameter to barbed suture diameter, then the better the closure strength when suturing a wound closed with a surgical needle attached to a barbed suture. In general, the thinner the surgical needle, the better the closure strength, particularly for delicate tissues; however, for tough tissues, such as muscle and bowel, thicker needles are preferred. Thus, what is important, regardless of whether the needle is thick or thin or somewhere in the middle, is that the ratio of surgical needle diameter to barbed suture diameter should be about 3:1 or less, more preferably about 2:1 or less.
- Although the present invention has been shown and described in detail with regard to only a few exemplary embodiments of the invention, it should be understood by those skilled in the art that it is not intended to limit the invention to the specific embodiments disclosed. Various modifications, omissions, and additions may be made to the disclosed embodiments without materially departing from the novel teachings and advantages of the invention, particularly in light of the foregoing teachings. For instance, the barbed suture of the present invention can be used alone or with other closure methods, such as staples and/or skin adhesives, to aid in holding the position of the tissue. Accordingly, it is intended to cover all such modifications, omissions, additions, and equivalents as may be included within the spirit and scope of the invention as defined by the following claims.
Claims (17)
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