US20060235448A1 - Artificial gastric valve - Google Patents
Artificial gastric valve Download PDFInfo
- Publication number
- US20060235448A1 US20060235448A1 US11/397,795 US39779506A US2006235448A1 US 20060235448 A1 US20060235448 A1 US 20060235448A1 US 39779506 A US39779506 A US 39779506A US 2006235448 A1 US2006235448 A1 US 2006235448A1
- Authority
- US
- United States
- Prior art keywords
- artificial gastric
- stomach
- food
- valve
- tract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/0003—Apparatus for the treatment of obesity; Anti-eating devices
- A61F5/0013—Implantable devices or invasive measures
- A61F5/003—Implantable devices or invasive measures inflatable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/0003—Apparatus for the treatment of obesity; Anti-eating devices
- A61F5/0013—Implantable devices or invasive measures
- A61F5/0036—Intragastrical devices
- A61F5/004—Intragastrical devices remotely adjustable
- A61F5/0043—Intragastrical devices remotely adjustable using injection ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/0003—Apparatus for the treatment of obesity; Anti-eating devices
- A61F5/0013—Implantable devices or invasive measures
- A61F5/005—Gastric bands
- A61F5/0053—Gastric bands remotely adjustable
- A61F5/0056—Gastric bands remotely adjustable using injection ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/132—Tourniquets
- A61B17/135—Tourniquets inflatable
- A61B17/1355—Automated control means therefor
Definitions
- the present invention relates to a method and apparatus for treating obesity, and more specifically the invention relates to an artificial gastric valve that can be implanted in a patient for treating obesity.
- obesity In the opinion of many health care experts, obesity is the largest health problem facing westernized societies and is considered an epidemic. From a medical standpoint, obesity is the primary risk factor for type 2 diabetes and obstructive sleep apnea. It increases the chances for heart disease, pulmonary disease, infertility, osteoarthritis, cholecystitis and several major cancers, including breast and colon. People with Body Mass Index (“BMI”) greater than 40 are considered morbidly obese. People with BMI between 30 and 40 are considered obese. Most importantly, high BMI has been shown to cause a reduction in life expectancy.
- BMI Body Mass Index
- Gastric Bypass is the most common surgical procedure performed to treat morbid obesity. The procedure involves using a stapler that cuts and divides tissue. This is used to produce a pouch that serves as a smaller stomach. This pouch is attached to a limb of divided intestine. Finally, intestinal continuity is restored by attaching the intestine to the intestine.
- the purpose of the gastric band is to create a narrowing in the proximal stomach that functions as a valve.
- the valve reduces the space available for food in the stomach and delays the emptying of the stomach. This hopefully makes people eat less and want to eat less frequently.
- the band can be tightened with the insertion of liquid through a port that is placed beneath the skin. New generations will offer band inflation without an invasive needle stick. However, the outlet would still remain fixed and the band would still represent a high pressure zone.
- the attraction of the band includes its low peri-operative morbidity and mortality. Since there is no alteration of the GI tract itself, recovery is rapid. However the fixed high pressure zone leads to numerous issues.
- a simple concept to reduce food intake is the placement of a space occupying balloon. These are inserted with the help of an endoscope. The balloon is inflated to 600 to 850 cc. This occupies a large portion of space in the stomach and leads to early satiety.
- trans gastric pacing utilized by Transneuronix, which was recently purchased by Medtronics, for a minimal value of 260 million dollars. With incentives, the deal could be worth one billion dollars.
- This approach involves the insertion of electrical leads on the lesser curvature of the stomach, close to the fibers of the vagus nerve. These leads are attached to a pacemaker.
- Cyberonics Inc. has investigated the use of vagus nerve stimulation for obesity.
- Favorable animal data lead to a six patient clinical pilot. Results were similar to what was reported by Transneuronix. Two patients did well, two had limited efficacy and two had no effect at all. The conclusion was that there was a real effect, but that more investigation was needed to master the needed signal.
- Leptos a new start up is investigating the use of splanchnic nerve stimulation. Similar to the vagus nerve, the splanchnic nerve is a conduit for information from the stomach and intestines to the brain. Promising animal data has been generated and pilot human trials are planned. Leptos has completed a second round of financing at a valuation of 12 million dollars.
- Pacing strategies are attractive since they would be low risk procedures. However, they will be expensive and efficacy may prove difficult. Contrary to cardiac pacemakers, there is no short term way of determining whether you have achieved your clinical objective. As a result, improvements will be difficult to prove.
- Trans-oral approaches offer the potential to have access to the GI tract without incision. Theoretically, procedures could be done in an outpatient setting without general anesthesia or endotracheal intubation. These approaches could limit morbidity and make the development of sepsis, wound breakdown and fistula less likely. Finally, the potential reduced cost of outpatient procedures could make treatment more affordable.
- the concept of an oral device is to occupy the space under the roof of the mouth. This forces patients to take smaller bites, eat slowly and hopefully eat smaller meals.
- the device called the DDS, (Scientific Intake) is inserted by the patient prior to eating and removed at the conclusion of the meal. Each person has an impression produced and the device custom made. A recent modification allows for a chip to be inserted to check for compliance.
- Satiety Inc. a privately held start up, which has an approach to internally reduce the size of the gastric reservoir. They are developing tissue fusion and suturing device to accomplish this goal.
- Staple breakdown rates of 10-20% have been reported for externally applied staplers.
- How internal sutures or fusion techniques will hold in the acidic gastric environment remains to be determined.
- open procedures unless these procedures were reinforced with synthetic bands, they had very short term efficacy.
- Another major question will be the regulatory path and follow up period that the FDA will find acceptable. If more than one year of follow up is required, these durability issues may prove terminal.
- Another technique to reproduce the benefits of a gastric bypass transorally are gastric sleeves or elephant trunks.
- the idea is to utilize a graft, that is anchored to the GI tract by an attachment device such as a stent.
- the graft would be lodged into the jejunum or proximal ileum. Food would travel down the conduit, not mixing with the digestive enzymes and reduce small bowel absorption. This could potentially be combined with a gastric restrictive device to imitate a gastric bypass.
- Others have also proposed combining such a technique with an Adjustable Laparoscopic Gastric Band.
- Insertion of foreign bodies into the gastro intestinal tract is different than placing stents into the vascular system.
- the graft will serve as an absorber of the transient pressure increases seen with food consumption.
- the band is a synthetic medical device that can be thought of as a ring that goes around the first portion of the stomach. Inside the ring is an inflatable balloon. This balloon can be tightened by inflating fluid that makes the outlet of the stomach smaller.
- the purpose is to make the recipient eat less food and smaller portions. While the lap band is adjustable this does not change the fact that the restriction is fixed. The lap band creates a high pressure zone that delays food intake past this point. This high pressure is transmitted to all places above the band. This can lead to dysphagia, dilatation of the stomach and esophagus above the band, regurgitation and reflux. Furthermore, the persistent high pressure would make it more difficult for a limited bolus of food to initiate satiety signals. While early, research has shown that ghrelin (a hormone that has been linked to satiety) levels stay persistently high in lap band patients. Low ghrelin levels have been reported in post bypass patients and are thought to be partially responsible for the post operative anorexia experienced by patients.
- ghrelin a hormone that has been linked to satiety
- the advantages of the lap band, compared to gastric bypass are multiple.
- the gastrointestinal tract does not have to permanently altered.
- the operative morbidity and mortality is much lower.
- results are more variable. 10% of recipients have minimal weight loss. Secondary to poor weight loss or other symptoms caused by the fixed obstruction, the re-operative surgical rate is also approximately 10%.
- a method to create restriction of food flow in the stomach involves a device called gastric band in which a band is tightened around part of the stomach.
- the band operation does not modify the GI tract at the time of surgery, however because the restrictive band is fixed in diameter, it can create long term complications.
- the fixed high pressure caused by the obstruction is transmitted to the gastro esophageal junction and esophagus. These structures are forced to accommodate this increased load. This can result in adaption of the pouch, esophageal dysfunction, and severe dysphagia.
- gastric bands are fixed in diameter with the ability to change the diameter via injection of liquid into a balloon. This type of diameter change involves a visit to the physician and is not dynamic. Thus people develop gastric pouch dilation, stoma obstruction, motility disturbances (pseudo achalasia), esophagitis and other symptoms related to a fixed barrier in the stomach.
- the desired device would need to be easily placed. It would need to be reversible. It would need to make people eat less feel less hungry. It would need to be activated when it is needed, not be locked in the on position. It would need to be able to be altered to meet changing clinical needs.
- the present invention relates to a device which automatically, dynamically and progressively controls the stoma opening by using an Artificial Gastric Valve (“AGV”) that is placed around part of the GI tract, preferably around the upper part of the stomach.
- AGV Artificial Gastric Valve
- the AGV can change its inside diameter on demand and thereby when the diameter of the AGV is reduced the stomach is compressed and a restriction of the flow of food in the stomach is created. Similarly, when the diameter is increased the stomach is relaxed to its natural state.
- the change of diameter of the AGV which creates a change of diameter of the stomach and therefore restricts the flow of food occurs at times which are a function of start of food intake or other bodily actions taken by the patient consciously or unconsciously in relation to the start of eating.
- a sensor senses one or more of the bodily actions that are taken immediately after start of eating such as for example receptive relaxation, esophageal relaxation near the GE junction as a result of a bolus of food going down to the stomach or the expansion of the stomach at the point where the AGV is located.
- the indication of start of eating causes the AGV diameter to reduce thereby constricting the stomach and restricting the flow of food.
- the range of variation in the inside diameter of the AGV can be from the natural diameter of the stomach down to a diameter of about 0.3 to 1 cm which amounts to almost a complete closure of the inside of the stomach.
- the device augments the natural body response to eating and creates a satiety feeling in addition to the main progressive restrictive effect which prevents the patient from excessive eating and causes weight loss without the side effects of a fixed diameter gastric band.
- the opening and closing of the AGV can be titrated to the individual patient by programming the software in an electronic controller. This will also have a block out feature, preventing too frequent activation and repetitive activation during the same time period. Additionally, the memory function will allow for the physician to understand how frequently the patient is eating.
- the proposed system consists of an AGV padded on the inside to prevent erosion of the stomach tissue, a restrictive mechanism for reducing and increasing the inside diameter of the AGV, a sensor indicating start of eating and an electronic controller including an algorithm for automatically deciding on changing the diameter of the AGV, a power source based on a battery and possibly a remote charging system for charging a rechargeable battery. All of the parts are inserted laporascopically into the body. On the outside of the body it is possible to have a control unit for communicating with the controller 5 in the body in order to collect pertinent information and to modify the algorithm by re-programming the software in the controller. In addition the part of the remote charging system and its energy supply are on the outside.
- the proposed device being on demand, dynamically and progressively constricting the flow of food where most of the time the AGV is relaxed and the stomach is at its natural state, prevents major problems associated with constant restriction of gastric bands and therefore will prevent patients from additional operations and need to take out the implanted AGV.
- Problems associated with constant diameter gastric bands include gastric pouch dilation, stoma obstruction, motility disturbances such as pseudo achalasia, esophagitis and other symptoms related to a fixed barrier in the stomach.
- letting the stomach return to its natural state ensures a more natural feeling of satiety not affected by adaption of the stomach wall to fixed high pressure.
- the present invention offers the combination of augmentation of satiety with the known effectiveness of gastric restriction.
- the approach is as logical and simple as ABC and has a far greater chance for long term success than the competition.
- the system is based on the lessons the founders have learned with open, laparoscopic and experimental pacing procedures. It is based on the understanding of the proximal gastro intestinal tract. As the device employ external restriction, it is believed that the path for regulatory approval and reimbursement will be more predictable than other start up firms in the obesity sector.
- FIG. 1 a is a block diagram of the AGV of the present invention.
- FIG. 1 b is an illustration of the AGV positioned with respect to the stomach.
- FIG. 2 a is a schematic top view of the AGV.
- FIG. 2 b is a schematic side view of the AGV.
- FIG. 3 is an illustration of a mechanical embodiment of the present invention.
- FIG. 4 is an illustration of a embodiment of the present invention that includes a piston.
- FIG. 5 is an embodiment of the present invention that includes a liquid reservoir and pump.
- FIG. 6 is a drawing of the present invention disposed within the human body.
- FIG. 7 is a drawing of a sensor disposed on a tooth.
- FIG. 8 is a flow chart of a first control algorithm.
- FIG. 9 is a flow chart of a second control algorithm.
- FIG. 10 is a flow chart of a subroutine for programming the controller of the present invention.
- the present invention relates to an Activated Bariatric Concept (“ABC”) which is based on the insight gained by treating thousands of bariatric surgical patients and performing an equal number of procedures.
- Eating begins with the passage of a bolus of food into the esophagus. This bolus travels with the aid of peristaltic forces that are locally generated towards the stomach.
- a valve called the lower esophageal sphincter. This valve relaxes to allow food to enter.
- the stomach which sits in a relaxed position, changes to allow food to enter.
- At the level of the fundus there is receptive relaxation. This means that the wall of the stomach relaxes to allow the food that is entering the stomach to cause a smaller increase in pressure.
- the purpose of the present invention is to augment the natural response of the body.
- the object of the present invention is to sense the initiation of food consumption and provide alteration of the gastric tract that mimics what occurs when a person begins to eat.
- a powered device is activated that constricts one area of the stomach and allows expansion and distension of other areas.
- the result is to both physically restrict the amount of food that is eaten, as well as promote the satiety signals that are produced when distension or increased pressure in the gastric lumen occurs. This unique approach also times the signals to coincide to the period when the body is most receptive.
- the preferred embodiment of the present invention includes an externally placed gastric constrictor that is attached to a power source and sensing arm. As the constrictor tightens, the area above will distend and a smaller amount of food will cause a transient rise in pressure in the proximal stomach. The purpose is to augment what occurs in the rapid eating period. Furthermore the proximally placed constricting ring or valve will limit the reservoir available for food intake. This system will combine gastric restriction, and augment satiety.
- a further modification could include a trans orally placed internal system that will be lodged into the lumen of the stomach. This system will be anchored to the gastric wall and distend when stimulated occupying space and placing stretch on the gastric wall. Contrary to balloons, this system will exist in the relaxed position thus preventing gastric accommodation.
- the purpose of the present invention is to place an artificial valve on the stomach and preferably at a much higher level of the stomach than is conventional in the art.
- the valve begins to tighten when wet swallowing or eating commences. This provides progressive gastric restriction, limits food intake and promotes early satiety.
- the valve gradually loosens providing controlled emptying of the stomach and causing reduced hunger.
- the dynamic nature of the valve will prevent long term motility and esophageal dilation.
- the present invention includes a device that augments the natural response of the body to eating and reduces food intake.
- the device is preferably referred to as an Artificial Gastric Valve (“AGV”) based on progressive physical restriction of part of the gastrointestinal (GI) tract, preferably the stomach, with the restriction being controlled by the initiation of food intake.
- AGV Artificial Gastric Valve
- GI gastrointestinal
- the device is left in the relaxed position. Thus permanent derangements in esophageal and stomach anatomy and function would not be expected.
- FIG. 1 a a block diagram illustrates the device, and it is divided into portions that are either inside the body or that are outside the body. The method of operation is hereby described according to FIG. 1 a .
- An AGV 2 made of semi rigid material or thin metal strip, is disposed around the upper part of the stomach 1 in perpendicular to the vertical disposition of the stomach 1 so that the inside diameter of the AGV 2 is in contact with the outer part of the stomach 1 at the position where the AGV 2 is encircling the stomach.
- FIG. 1 b A preferred position of the AGV is shown in FIG. 1 b .
- the restrictive mechanism 3 is capable of constricting the AGV 2 as well as relaxing it.
- the restrictive mechanism 3 is capable of progressively reducing the inside diameter of the AGV 2 , creating a pressure on the stomach so that the diameter of the stomach is reduced and the flow of food through the stomach is restricted.
- a sensor 4 is capable of sensing the bodily reactions to the start of food ingestion and to send a signal indicating start of eating to a controller B 5 .
- the controller B 5 uses an algorithm 5 a , upon receiving the signal of start of eating from the sensor 4 , sends a signal to the restrictive mechanism 3 to operate, reduce the diameter of the AGV 2 and create a restriction on food flow. As a result the patient is prevented from eating excessively. After the patient stops eating, the controller B 5 sends a signal to the restrictive mechanism to relax and allows the stomach 1 to get back to its original diameter and natural state.
- the controller B 5 is using the algorithm 5 a to decide on the time between start of eating and close of the AGV 2 , the rate of closing the AGV 2 and the extent to which the AGV 2 is closed. Similarly the controller B 5 decides on how long after start of eating the AGV 2 opens, at what rate of opening and to what extent.
- the algorithm 5 a can be designed and individually adapted to the patient based on his or her eating habits and anatomy.
- the algorithm 5 a can be modified from outside the body by wireless signals from controller A 9 disposed outside the body to controller B 5 inside the body.
- controller A 9 can receive information from controller B 5 via bi-directional wireless communication to allow the physician to collect data and information on the times of operation of the restrictive mechanism 3 .
- the physician can modify the algorithm 5 a to allow the patient more or less freedom to eat by changing the time at which the restrictive mechanism 3 starts to operate after the patient starts to eat, the rate of opening, the extent of opening and the time the mechanism 3 relaxes the AGV 2 , the rate of relaxation and the extent of relaxation.
- the controller B 5 , restrictive mechanism 3 and sensor 4 for start of eating receive electrical power from a power source such as a battery or power source 6 . If needed, such battery can be charged using a remote charger A 8 which inductively transmits energy to charger B 7 for charging such battery.
- the algorithm 5 a preferably includes at least two embodiments as illustrated in the flow charts of FIGS. 8 and 9 .
- the algorithm 5 a controls the AGV 2 in accordance with an input signal from a sensor 4 .
- the AGV 2 is constricted in accordance with stored parameters and the timing of the constriction is stored in the memory of either controllers 5 , 9 .
- the relaxation of the AGV 2 is also controlled in accordance with the input signal from the sensor 4 and stored parameters.
- the algorithm 5 a controls the AGV 2 in accordance with arbitrary times that are programmed into the controllers 5 , 9 .
- arbitrary or predetermined times correspond to time periods when food is expected to be ingested.
- the AGV 2 is constricted in accordance with stored parameters and the timing of the constriction is stored in the memory of either controllers 5 , 9 .
- the relaxation of the AGV 2 is also controlled in accordance with arbitrary times and stored parameters. If desired the relaxation of the AGV 2 may be delayed by a predetermined time period determined by a physician.
- the stored parameter are programmed into the controllers 5 , 9 in accordance with the subroutine illustrated in the flow chart of FIG. 10 . It is also possible that the AGV 2 may be constricted and relaxed in accordance with input from the sensor 4 and at arbitrary or predetermined times programmed into the controllers 5 , 9 .
- the AGV 2 without the restrictive device 3 is shown in FIG. 2 a and FIG. 2 b .
- the AGV 2 is originally made of a long strip 10 shown in a top view having a predetermined length and width, made of semi rigid material, with ends 11 and 12 that connect to each other.
- the connection of the two ends could be with a buckle or a snap-on or other method to form a closed loop for embodiments in which the outer diameter of the AGV stays constant, or could be of a different type connection, such as connecting directly to a motor for other embodiments in which the outside diameter of the AGV changes during operation of the AGV.
- the length and width of strip 10 are approximately 10 cm and 1-5 cm respectively.
- a side view of side 13 of the AGV 2 is shown in FIG. 2 b .
- the inside of the strip 10 is padded with a cushioning material 14 that prevents erosion of the stomach tissue as a result of restricting and relaxing the stomach by the AGV 2 .
- the material can be soft material in one preferred embodiment and could be a balloon filled with liquid or gas in other embodiments.
- the balloon could be sealed, or could be connected to a source of liquid or gas and a restrictive mechanism inflates or deflates said balloon on demand.
- the AGV 2 is inserted into the body laporascopically, disposed around the stomach and the two ends of the strip 10 are connected together to create a closed loop, leaving the soft cushioning portion 14 in contact with the stomach tissue.
- the sensor 4 for start of eating relies on a known clinical fact that the process of start of eating is responsible for a series of bodily actions such as receptive relaxation of the stomach, saliva secretion, chewing, swallowing, secretion of hormones, change in blood glucose level, change in heart rate variability, expansion of the stomach and more.
- the sensor 4 for start of eating senses one or more of such bodily actions.
- the receptive relaxation of the stomach can be sensed by strain gauges attached to the outside of the stomach or by sensing the electrical signals associated with receptive relaxation. Such signals can be measured with electrodes attached to the outside wall of the stomach or by electromagnetic sensors in a way similar to the method of cutaneous Electro Gastro-Graphy (EGG).
- ECG cutaneous Electro Gastro-Graphy
- the electromagnetic sensing can be done inside the body, or can be done cutaneously and the results can be transmitted to controller A 9 .
- the sensor 4 can be placed in the oral cavity and be designed to detect the pressure of mastication or other oral signal.
- the sensor can also be placed at the level of the esophagus and can be internally placed by endoscopy to sit on the mucousa.
- the sensor 4 can be placed around the GE junction and detect pressure change, motion, or expansion of this area with the passage of a bolus of food.
- the sensor 4 could be placed anyplace within or external to the GI tract, with the purpose of activating a system that either constricts or distends the stomach.
- the sensor signal can include an ultrasound, infrared, electrical, radio frequency, magnetic, motion signal, that is directed at the lumen of the stomach or esophagus and initiates the process. For example as food goes through the lumen of the GI tract a signal is sent, and when this is absorbed, deflected or altered by food or luminal contents activates the system. Similarly a reflector could be placed opposite the signal and whenever the reflector is blocked the system is activated.
- the sensor can be current and voltage measurements on the stomach to measure parameters such as stomach impedance which correlates with start of eating.
- the sensor could be a infrared beam that is combined with spectroscopy to detect a change in tissue perfusion, such as an increase in oxygen saturation which correlates to increased arterial blood flow to the stomach when food arrives at the stomach and it is active.
- the sensor could be other measure of increased blood flow to the stomach or other signal such as temperature change, change in local chemistry, which detect a subtle change in local environment.
- the sensor 4 could also be placed in the arm or in a combination of places and detect a motion or action that is consistent with bringing food toward the GI tract.
- the sensor 4 could detect changes in saliva or other GI tract secretion that is produced with the onset of eating.
- the system can be placed on and constrict the stomach at a steady rate controlled manner to a predetermined level.
- the sensor 4 can serve as a gradient and each time the system detects food the constrictor is tightened or an internal system is inflated progressively.
- the system controller is equipped with a memory.
- the purpose is to determine the number of times the system is activated. This information can be used to change speed of constriction or inflation, provide information for clinicians and alter the rate of emptying or any of the parameters of the system.
- the memory can also store dietary information related to the output of sensor 4 or other sensors, for example a blood sugar sensor, that are coupled to the internal controller 5 .
- the memory can function as an internal data base of information and data that can be extracted by a physician utilizing the external controller 9 .
- the mechanism for progressive restriction of the stomach is mechanical in nature and acts directly on the AGV to tighten it or release it.
- Such mechanical action can be done for example by pulling one side of the strip 10 around the other part or inside the other part by use of a small motor as shown in FIG. 3 .
- the stomach cross section is indicated by 20
- the cushioning 21 can be a soft material or a sealed balloon.
- a small motor 23 acts on the AGV 22 to reduce its diameter by pulling or releasing one end of the AGV in relation to the other end of the AGV.
- the AGV itself does not change in dimensions, only a balloon 36 on the inside of the AGV is changes its volume and pressure.
- the stomach cross section is indicated by 32
- the AGV is indicated by 30 with 33 being the connection of the two ends of the AGV.
- a balloon 36 is connected to a tube 34 having a piston 39 and a mechanism to push liquid through the tube and into said balloon 36 .
- the inside 31 of the balloon 36 pushes against the stomach 32 .
- the borders of the balloon are indicated by 31 on the inside and 30 on the outside.
- the balloon 36 connects to the tube 34 and a piston, and the balloon 36 and the tube 34 are filled with a liquid such as saline solution.
- a motor 35 acts on the piston and thereby increases or decreases the pressure in the balloon 36 and therefore increases or decreases the diameter of the AGV on demand in a progressive manner.
- the pushing can be done by compressing a bellow filled with liquid.
- the stomach 41 is encircled with an AGV 42 and a balloon 43 similarly to embodiment 200 .
- the balloon 43 is filled with liquid, such as saline solution, and is connected via a tube 44 to a reservoir 45 and a pump 46 .
- the pump controlled by the controller B 5 , can pump the liquid into the balloon and out of the balloon and increase or decrease the diameter of the stomach 41 to create a progressive restriction on the flow of food and relaxation of the stomach when the patient is not eating.
- the system can be designed as a ring, helix or blanket. It could have compartments that are activated at different or the same time.
- the system could also be placed internally as a bezoar into the stomach anchored by an attachment to the gastric wall. Food would hit the sensor which would cause the inflation of the bezoar causing gastric distension.
- rate of inflation and deflation could be altered based on feedback of the system or device history.
Abstract
Description
- This application claims the benefit under
Title 35, U.S.C. §119 (e) of U.S. provisional application 60/670,546 filed on Apr. 13, 2005, the entire contents of which are hereby incorporated by reference. - 1. Field of the Invention
- The present invention relates to a method and apparatus for treating obesity, and more specifically the invention relates to an artificial gastric valve that can be implanted in a patient for treating obesity.
- 2. Description of the Related Art
- In the opinion of many health care experts, obesity is the largest health problem facing westernized societies and is considered an epidemic. From a medical standpoint, obesity is the primary risk factor for
type 2 diabetes and obstructive sleep apnea. It increases the chances for heart disease, pulmonary disease, infertility, osteoarthritis, cholecystitis and several major cancers, including breast and colon. People with Body Mass Index (“BMI”) greater than 40 are considered morbidly obese. People with BMI between 30 and 40 are considered obese. Most importantly, high BMI has been shown to cause a reduction in life expectancy. - From an economic standpoint, it is estimated that more than 100 billion dollars are spent on obesity and treating its major co-morbidities. This does not even consider the psychological and social costs of this epidemic problem. Despite these alarming facts, treatment options for obesity remain limited. The desire to eat and the body's counter regulatory system when caloric intake is reduced, makes the treatment of obesity quite a difficult task.
- The obesity epidemic and its medical impact have been well documented. Currently over 50 billion dollars are spent on over the counter weight loss products and programs. The number of invasive surgical procedures such as gastric bypass and lap band being performed for severe obesity is rapidly increasing. In the past 5 years there has been a 450% increase in surgical procedures for obesity. On average these procedures cost more than $25,000. Furthermore, the complicated nature of these procedures and potential for negative long term effects make only the most obese candidates for these procedures. Despite the efficacy of current surgical procedures, there is a large opportunity to vastly improve their effectiveness and limit their complications. It is only in the last several years, that a majority of health care providers viewed obesity as a disease that justified invasive and aggressive management. The data for the negative impact of obesity on health is now overwhelming. Current procedures are merely first generation approaches and have not made an overall impact on obesity treatment and prevention. Consequently, there is a large market opportunity for medical devices that better understand the pathophysiology of obesity.
- With over 60% of the United States Population obese or overweight, market size is limited only by the development of safe and effective technology. Currently, 150,000 bariatric cases are performed in the US. Approximately, 30,000 are lap bands. At present, staplers and medical devices for obesity are approximately a 500, million dollar market. This does not include the 50 billion dollars spent on weight loss products and programs. Nor does it include the estimated 100 billion dollar cost treating the complications of obesity. With the large discrepancy between need and effective treatments, most analysts believe that the obesity market could rival the cardiac stent market if proper devices are developed. The devices developed to date all have issues.
- Gastric Bypass
- Gastric Bypass is the most common surgical procedure performed to treat morbid obesity. The procedure involves using a stapler that cuts and divides tissue. This is used to produce a pouch that serves as a smaller stomach. This pouch is attached to a limb of divided intestine. Finally, intestinal continuity is restored by attaching the intestine to the intestine.
- Numerous things happen when a gastric bypass is performed. The new stomach is smaller and holds less food. Food goes directly into the small intestine, bypassing the bottom portion of the stomach and the initial area of the intestine. Food does not mix with the digestive juices from the liver and pancreas until a large potion of the GI tract has been passed. As a result, the operation makes people eat less and causes impaired absorption of food, minerals and vitamins.
- While effective, the bypass can cause numerous long term issues. There is a real mortality rate associated with the procedure. Poor iron absorption can cause anemia. Poor calcium absorption could cause osteopenia. Poor vitamin absorption can cause deficiency in Vitamin A, D, or thiamine. Additionally, there is a risk of marginal ulcer, stricture, and other morbidity.
- For these reasons, the number of patients seeking gastric bypass appears to have stabilized. For the last five years, growth has been exponential. Currently, patients are searching for the efficacy of bypass without the potential complications.
- Besides the standard gastric bypass, there are other procedures that are similar. They include banded bypass, bilio-pancreatic diversion with duodenal switch and Scopinaro procedure. All combine some gastric alteration with an intestinal bypass. All offer weight loss. But all have a short and long term complication profile that preclude them from being considered ideal treatments.
- Presently, all these procedures can be performed laparoscopically. While this offers faster recovery, reduced pain, and lower risk of hernia formation, it does not eliminate the short and long term complications associated with gastric bypass.
- Laparoscopic Adjustable Gastric Banding
- The purpose of the gastric band is to create a narrowing in the proximal stomach that functions as a valve. The valve reduces the space available for food in the stomach and delays the emptying of the stomach. This hopefully makes people eat less and want to eat less frequently. The band can be tightened with the insertion of liquid through a port that is placed beneath the skin. New generations will offer band inflation without an invasive needle stick. However, the outlet would still remain fixed and the band would still represent a high pressure zone.
- The attraction of the band includes its low peri-operative morbidity and mortality. Since there is no alteration of the GI tract itself, recovery is rapid. However the fixed high pressure zone leads to numerous issues.
- Certain patients never achieve an acceptable level of weight loss. When the band is tightened to enhance effect, there can be dilation of the pouch above the band and the esophagus. Patients complain of regurgitation and dysphagia. Also the high pressure that is transmitted proximally causes a stomach that is more resistant to distension and the forces caused by food bolus.
- Several companies are expected to enter the LAGB market. Ethicon Inc, a division of Johnson and Johnson is expecting approval of there obtech band in 2007. Additionally they have accumulated IP that involves improved design including self adjustment. Other band companies in Europe include Mid-Band and Helioscope. A new entry is Endo-Art which offers an improved method of non invasive band adjustment.
- Gastric Balloons
- A simple concept to reduce food intake is the placement of a space occupying balloon. These are inserted with the help of an endoscope. The balloon is inflated to 600 to 850 cc. This occupies a large portion of space in the stomach and leads to early satiety.
- There are numerous issues that have limited the clinical usefulness of balloons. The harsh acidic environment of the stomach can cause destruction of the balloon. As a result, the balloon needs to be replaced every six months. More importantly, the large balloon causes the stomach to reset. Since there is no external restriction the stomach can dilate. In fact the stomach can dilate to quite extreme levels. As the volume of a sphere changes with the radius to the third power, even a small level of dilatation can lead to an impressive increase in the size of the gastric reservoir.
- As a result, most view balloons as a bridge for very high risk patients, to more efficacious treatment modalities, such as gastric bypass. Old version of the balloon such as the Taylor or Guerin balloons were recalled from the market. Bioenterics, the maker of the lap band has re-introduced the Bioenterics intra-gastric balloon, with their improved silicone.
- Gastric Pacing
- There are several investigational designs that have explored using electrical stimulation with the use of a pacemaker to either the gastric tract or essential nerves. The most investigated is trans gastric pacing utilized by Transneuronix, which was recently purchased by Medtronics, for a minimal value of 260 million dollars. With incentives, the deal could be worth one billion dollars.
- This approach involves the insertion of electrical leads on the lesser curvature of the stomach, close to the fibers of the vagus nerve. These leads are attached to a pacemaker.
- There are numerous theories regarding the effect of gastric pacing. The orginal hypothesis was that the pacing interfered with the normal electrical system of the stomach and caused a delay in gastric emptying. This delay would allow the stomach to stay full and reduce food ingestion. Unfortunately, gastric emptying studies failed to show consistent delay in gastric emptying. More recent theories involve stimulation of enteric nerves, and local hormonal factors.
- Several large trials that have included sham arms have investigated the efficacy of gastric pacing. To date, they have not shown consistent efficacy. Recently, Medtronic announced that the most recent trial failed to demonstrate weight loss.
- Another version using similar technology is being employed by Impulse Dynamics which is a privately held Israeli based. In their system, impedance is measured and the gastric pacing is linked to a change in impedance. Clinical trials are being done in Vienna and the USA.
- Cyberonics Inc. has investigated the use of vagus nerve stimulation for obesity. Favorable animal data lead to a six patient clinical pilot. Results were similar to what was reported by Transneuronix. Two patients did well, two had limited efficacy and two had no effect at all. The conclusion was that there was a real effect, but that more investigation was needed to master the needed signal.
- Leptos, a new start up is investigating the use of splanchnic nerve stimulation. Similar to the vagus nerve, the splanchnic nerve is a conduit for information from the stomach and intestines to the brain. Promising animal data has been generated and pilot human trials are planned. Leptos has completed a second round of financing at a valuation of 12 million dollars.
- Perhaps the most futuristic approach is being developed by Intrapace. Their approach is to design an internally placed pacemaker that is inserted through a trans-oral approach. In addition to all the unknowns that the other stimulation products have, this approach adds new dimensions. They include the need for a small or rechargeable battery, limited space, the harsh gastric environment and the difficulty in generating the high power signal believed necessary to stimulate small C fibers.
- All pacing concepts are based on stimulating the intrinsic wiring of the stomach and mimic what happens when the stomach is stimulated by the ingestion of food. The problem is that while we know that this wiring exists, we do not know the morse code needed to decipher. The pacers generate an electrical signal that goes on or off. There is no crescendo or decrescendo response. Only Impulse Dynamics tries to overcome this obstacle. Additionally, there is no physiologic response to titrate the response. Thus only expensive clinical trials can be performed to see if the pacing is effective. The Transneuronix experience highlights these issues.
- Many patients lost weight in their clinical trial. However, when compared to placebo the response was not statistically significant. Other, than repeat an entire trial with different pacing parameters or a patient selection, there is little that can be done. Basically, improved parameters will need to be guessed and only a lengthy trial will determine whether effective.
- Pacing strategies are attractive since they would be low risk procedures. However, they will be expensive and efficacy may prove difficult. Contrary to cardiac pacemakers, there is no short term way of determining whether you have achieved your clinical objective. As a result, improvements will be difficult to prove.
- Other hurdles besides clinical approval, will be gaining reimbursement. These devices will be expensive and require battery change at regular intervals. Even if FDA requirements for pre-market approval are met, it will be a long time before reimbursement is obtained from a majority of commercial insurance plans. Furthermore, approval for Medicare reimbursement will be difficult. The expense of these devices and the cost of invasive implant and the need for battery change will reduce the number of potential self or cash pay recipients.
- Endoscopic or Trans Oral Restriction or Sleeves
- Trans-oral approaches offer the potential to have access to the GI tract without incision. Theoretically, procedures could be done in an outpatient setting without general anesthesia or endotracheal intubation. These approaches could limit morbidity and make the development of sepsis, wound breakdown and fistula less likely. Finally, the potential reduced cost of outpatient procedures could make treatment more affordable.
- There is an extensive list of trans-oral approaches that are being developed. These include oral devices, bezoars that occupy space in the stomach, internal suturing devices, stents and grafts that serve as a conduit for food bypassing areas of caloric absorption, gastric clamping or fusion techniques, radiofrequency ablation and intra gastric pacing. At present, an oral device and a balloon that occupies space have been utilized in clinical practice. Endoscopic suturing has been done for gastric fistulas and dilated gastrojejunostomy attachments with promising early results. Suturing has also been done as a primary procedure for obesity in South America.
- Oral Devices
- The concept of an oral device is to occupy the space under the roof of the mouth. This forces patients to take smaller bites, eat slowly and hopefully eat smaller meals. The device, called the DDS, (Scientific Intake) is inserted by the patient prior to eating and removed at the conclusion of the meal. Each person has an impression produced and the device custom made. A recent modification allows for a chip to be inserted to check for compliance.
- At present the device has been utilized by over 3000 people. There are no reports of any significant adverse events. An acute study performed at Pennington Institute revealed that the study group eat 23% less food and this was associated with a six pound weight loss. A multi-centered FDA trial was scheduled to begin in January of 2006, to objectively study the device and the compliance pattern of patients.
- The future market of this device is not designed to be competitive with the companies products. This approached is being advocated as a first line and for those with minimal obesity. For success there will need to be compliance and extensive behavior modification will be combined with the oral device.
- Internal Suturing and Gastric Clamping
- Several approaches are being designed to reduced the size of the stomach and perform an internal restrictive obesity operation. The idea is to reduce gastric capacity similar to what is done with a vertical banded gastroplasty. Several established and startup companies are examining these techniques. They are attempting to utilize either a combination of a suturing device and methods that fuse the walls of the stomach.
- Satiety Inc. a privately held start up, which has an approach to internally reduce the size of the gastric reservoir. They are developing tissue fusion and suturing device to accomplish this goal. There are several major issues. First there is the technical challenge of designing an endoscopic product that fits through a currently available endoscope or overtube to perform the procedure. Furthermore, if accomplished the durability of these procedures will have to be questioned. Staple breakdown rates of 10-20% have been reported for externally applied staplers. How internal sutures or fusion techniques will hold in the acidic gastric environment, remains to be determined. Furthermore, in open procedures, unless these procedures were reinforced with synthetic bands, they had very short term efficacy. Another major question will be the regulatory path and follow up period that the FDA will find acceptable. If more than one year of follow up is required, these durability issues may prove terminal.
- Gastric Sleeves
- Another technique to reproduce the benefits of a gastric bypass transorally are gastric sleeves or elephant trunks. The idea is to utilize a graft, that is anchored to the GI tract by an attachment device such as a stent. The graft would be lodged into the jejunum or proximal ileum. Food would travel down the conduit, not mixing with the digestive enzymes and reduce small bowel absorption. This could potentially be combined with a gastric restrictive device to imitate a gastric bypass. Others have also proposed combining such a technique with an Adjustable Laparoscopic Gastric Band.
- Numeorus start up companies that have raised capital at valuations approaching 20 million dollars, have taken this approach. They include GI Dynamics, Barosense and GastroRx.
- Issues with sleeves or conduit procedures include, difficulty in fixation, potential for obstruction and kinking, migration and an unknown effect on food consumption. As food is in reduced contact with intestinal mucosa, this could actually stimulate recipients to eat more to compensate.
- Insertion of foreign bodies into the gastro intestinal tract is different than placing stents into the vascular system. There are strong muscular contractions called peristalsis that drives food down the intestinal tract. These forces will make these devices difficult to anchor. Thus they will migrate and kink and cause intestinal obstruction. Additionally, the graft will serve as an absorber of the transient pressure increases seen with food consumption.
- These devices will have to overcome all these technical barriers. Once these are overcome, then efficacy will need to be determined. These devices have no real precedent surgical procedure to predict their long term effectiveness and durability.
- Most Common Techniques
- The most common operation in the United States is the Gastric Bypass. With gastric bypass many investigators have reported weight loss results that exceed 70% of excess weight. However, this efficacy does not come without complication. The accepted mortality of the procedure is 1 in 200. Even higher figures have recently been reported among beneficiaries of medicare. Furthermore, there is an increasing recidivism rate. Weight gain of 10 to 40% of maximum weight loss has been reported. Immediately after surgery, most patients report less desire to eat. Unfortunately, 6 to 12 months after surgery the urge to eat seems to return. Most, still cannot eat the portion size they once consumed. However they replace this with eating small amounts of calorically dense foods more often. There can be expansion of the pouch and dilation of the attachment between the stomach and the intestine.
- Another view, is that the operation is fixed and unlikely to work better than immediately after it was performed. As the patient challenges the procedure, the tissue changes to allow more food to enter. The negative reinforcement the operation offers decreases over time. We learn what to eat, how to eat it and sub consciously learn tricks that allow us to return to the habits that made the patient obese.
- Other common techniques include the lap band or adjustable gastric bands which have similar limitations. The band is a synthetic medical device that can be thought of as a ring that goes around the first portion of the stomach. Inside the ring is an inflatable balloon. This balloon can be tightened by inflating fluid that makes the outlet of the stomach smaller.
- The purpose is to make the recipient eat less food and smaller portions. While the lap band is adjustable this does not change the fact that the restriction is fixed. The lap band creates a high pressure zone that delays food intake past this point. This high pressure is transmitted to all places above the band. This can lead to dysphagia, dilatation of the stomach and esophagus above the band, regurgitation and reflux. Furthermore, the persistent high pressure would make it more difficult for a limited bolus of food to initiate satiety signals. While early, research has shown that ghrelin (a hormone that has been linked to satiety) levels stay persistently high in lap band patients. Low ghrelin levels have been reported in post bypass patients and are thought to be partially responsible for the post operative anorexia experienced by patients.
- The advantages of the lap band, compared to gastric bypass are multiple. The gastrointestinal tract does not have to permanently altered. There is no malabsorption of vitamins and minerals. The operative morbidity and mortality is much lower. On the other hand, results are more variable. 10% of recipients have minimal weight loss. Secondary to poor weight loss or other symptoms caused by the fixed obstruction, the re-operative surgical rate is also approximately 10%.
- As stated above, it is estimated that up to 60% of the population in the United States is obese or overweight. Of these patients, 5-6% are considered morbidly obese because they are approximately 50 kg above their ideal body weight. Treatment options include dietary modification, very low calorie liquid diet, pharmaceutical agents, counseling, exercise programs and surgery. Surgical procedures that restrict the size of the stomach and/or bypass parts of the intestine are the only remedies that provide lasting weight loss for the majority of morbidly obese individuals. Surgical procedures for morbid obesity are becoming more common based on long-term successful weight loss result. Increase awareness regarding the dangers of obesity combined with the fact that these procedures are now being done with a laparosope, in a minimally invasive manner, have made these procedures one of the fastest growing areas of surgery.
- The surgeries which create malabsorption, such as the by-pass operation, although effective in weight reduction, involve permanent modification of the GI tract and have a risk of short and long term complication and even death. A method to create restriction of food flow in the stomach involves a device called gastric band in which a band is tightened around part of the stomach. The band operation does not modify the GI tract at the time of surgery, however because the restrictive band is fixed in diameter, it can create long term complications. The fixed high pressure caused by the obstruction is transmitted to the gastro esophageal junction and esophagus. These structures are forced to accommodate this increased load. This can result in adaption of the pouch, esophageal dysfunction, and severe dysphagia. At present, only 50% of band recipients have what is considered a successful bariatric procedure. Annually 5% of patients require revision or band removal. Present day gastric bands are fixed in diameter with the ability to change the diameter via injection of liquid into a balloon. This type of diameter change involves a visit to the physician and is not dynamic. Thus people develop gastric pouch dilation, stoma obstruction, motility disturbances (pseudo achalasia), esophagitis and other symptoms related to a fixed barrier in the stomach.
- This review of the obesity device field, emphasizes the need for a better surgical device for the treatment of obesity. The desired device would need to be easily placed. It would need to be reversible. It would need to make people eat less feel less hungry. It would need to be activated when it is needed, not be locked in the on position. It would need to be able to be altered to meet changing clinical needs.
- The present invention relates to a device which automatically, dynamically and progressively controls the stoma opening by using an Artificial Gastric Valve (“AGV”) that is placed around part of the GI tract, preferably around the upper part of the stomach. The AGV can change its inside diameter on demand and thereby when the diameter of the AGV is reduced the stomach is compressed and a restriction of the flow of food in the stomach is created. Similarly, when the diameter is increased the stomach is relaxed to its natural state.
- The change of diameter of the AGV which creates a change of diameter of the stomach and therefore restricts the flow of food occurs at times which are a function of start of food intake or other bodily actions taken by the patient consciously or unconsciously in relation to the start of eating. When the patient starts eating, a sensor senses one or more of the bodily actions that are taken immediately after start of eating such as for example receptive relaxation, esophageal relaxation near the GE junction as a result of a bolus of food going down to the stomach or the expansion of the stomach at the point where the AGV is located. The indication of start of eating causes the AGV diameter to reduce thereby constricting the stomach and restricting the flow of food. After eating, the AGV relaxes to its natural state and the stomach is relaxed back to its original condition. The range of variation in the inside diameter of the AGV can be from the natural diameter of the stomach down to a diameter of about 0.3 to 1 cm which amounts to almost a complete closure of the inside of the stomach. The device augments the natural body response to eating and creates a satiety feeling in addition to the main progressive restrictive effect which prevents the patient from excessive eating and causes weight loss without the side effects of a fixed diameter gastric band. The opening and closing of the AGV can be titrated to the individual patient by programming the software in an electronic controller. This will also have a block out feature, preventing too frequent activation and repetitive activation during the same time period. Additionally, the memory function will allow for the physician to understand how frequently the patient is eating.
- The proposed system consists of an AGV padded on the inside to prevent erosion of the stomach tissue, a restrictive mechanism for reducing and increasing the inside diameter of the AGV, a sensor indicating start of eating and an electronic controller including an algorithm for automatically deciding on changing the diameter of the AGV, a power source based on a battery and possibly a remote charging system for charging a rechargeable battery. All of the parts are inserted laporascopically into the body. On the outside of the body it is possible to have a control unit for communicating with the
controller 5 in the body in order to collect pertinent information and to modify the algorithm by re-programming the software in the controller. In addition the part of the remote charging system and its energy supply are on the outside. - The proposed device being on demand, dynamically and progressively constricting the flow of food where most of the time the AGV is relaxed and the stomach is at its natural state, prevents major problems associated with constant restriction of gastric bands and therefore will prevent patients from additional operations and need to take out the implanted AGV. Problems associated with constant diameter gastric bands include gastric pouch dilation, stoma obstruction, motility disturbances such as pseudo achalasia, esophagitis and other symptoms related to a fixed barrier in the stomach. In addition, letting the stomach return to its natural state ensures a more natural feeling of satiety not affected by adaption of the stomach wall to fixed high pressure.
- The present invention offers the combination of augmentation of satiety with the known effectiveness of gastric restriction. As the name suggests the approach is as logical and simple as ABC and has a far greater chance for long term success than the competition. The system is based on the lessons the founders have learned with open, laparoscopic and experimental pacing procedures. It is based on the understanding of the proximal gastro intestinal tract. As the device employ external restriction, it is believed that the path for regulatory approval and reimbursement will be more predictable than other start up firms in the obesity sector.
-
FIG. 1 a is a block diagram of the AGV of the present invention. -
FIG. 1 b is an illustration of the AGV positioned with respect to the stomach. -
FIG. 2 a is a schematic top view of the AGV. -
FIG. 2 b is a schematic side view of the AGV. -
FIG. 3 is an illustration of a mechanical embodiment of the present invention. -
FIG. 4 is an illustration of a embodiment of the present invention that includes a piston. -
FIG. 5 is an embodiment of the present invention that includes a liquid reservoir and pump. -
FIG. 6 is a drawing of the present invention disposed within the human body. -
FIG. 7 is a drawing of a sensor disposed on a tooth. -
FIG. 8 is a flow chart of a first control algorithm. -
FIG. 9 is a flow chart of a second control algorithm. -
FIG. 10 is a flow chart of a subroutine for programming the controller of the present invention. - The present invention relates to an Activated Bariatric Concept (“ABC”) which is based on the insight gained by treating thousands of bariatric surgical patients and performing an equal number of procedures. Eating begins with the passage of a bolus of food into the esophagus. This bolus travels with the aid of peristaltic forces that are locally generated towards the stomach. At the junction of the esophagus and the stomach there exists a valve called the lower esophageal sphincter. This valve relaxes to allow food to enter. The stomach, which sits in a relaxed position, changes to allow food to enter. At the level of the fundus there is receptive relaxation. This means that the wall of the stomach relaxes to allow the food that is entering the stomach to cause a smaller increase in pressure.
- Humans eat in a certain pattern. At first they eat rapidly. Then the pace slows as the stomach fills and the amount of distension and pressure on the stomach increases. These incremental forces create signals that travel from the stomach to the central nervous system and give the feeling of fullness and satiety. Past a certain point they may cause a feeling of bloating and discomfort. These gastric forces, are the bodies strongest satiety signals. This point is highlighted by the speed we begin our meals, followed by slower eating, until meal cessation.
- The purpose of the present invention is to augment the natural response of the body. The object of the present invention is to sense the initiation of food consumption and provide alteration of the gastric tract that mimics what occurs when a person begins to eat. Thus at the origin of eating a powered device is activated that constricts one area of the stomach and allows expansion and distension of other areas. The result is to both physically restrict the amount of food that is eaten, as well as promote the satiety signals that are produced when distension or increased pressure in the gastric lumen occurs. This unique approach also times the signals to coincide to the period when the body is most receptive.
- The preferred embodiment of the present invention includes an externally placed gastric constrictor that is attached to a power source and sensing arm. As the constrictor tightens, the area above will distend and a smaller amount of food will cause a transient rise in pressure in the proximal stomach. The purpose is to augment what occurs in the rapid eating period. Furthermore the proximally placed constricting ring or valve will limit the reservoir available for food intake. This system will combine gastric restriction, and augment satiety.
- A further modification could include a trans orally placed internal system that will be lodged into the lumen of the stomach. This system will be anchored to the gastric wall and distend when stimulated occupying space and placing stretch on the gastric wall. Contrary to balloons, this system will exist in the relaxed position thus preventing gastric accommodation.
- The purpose of the present invention is to place an artificial valve on the stomach and preferably at a much higher level of the stomach than is conventional in the art. The valve begins to tighten when wet swallowing or eating commences. This provides progressive gastric restriction, limits food intake and promotes early satiety. The valve gradually loosens providing controlled emptying of the stomach and causing reduced hunger. The dynamic nature of the valve will prevent long term motility and esophageal dilation.
- The present invention includes a device that augments the natural response of the body to eating and reduces food intake. The device is preferably referred to as an Artificial Gastric Valve (“AGV”) based on progressive physical restriction of part of the gastrointestinal (GI) tract, preferably the stomach, with the restriction being controlled by the initiation of food intake. During periods when food is not being ingested, the device is left in the relaxed position. Thus permanent derangements in esophageal and stomach anatomy and function would not be expected.
- Referring now to
FIG. 1 a, a block diagram illustrates the device, and it is divided into portions that are either inside the body or that are outside the body. The method of operation is hereby described according toFIG. 1 a. AnAGV 2 made of semi rigid material or thin metal strip, is disposed around the upper part of thestomach 1 in perpendicular to the vertical disposition of thestomach 1 so that the inside diameter of theAGV 2 is in contact with the outer part of thestomach 1 at the position where theAGV 2 is encircling the stomach. - A preferred position of the AGV is shown in
FIG. 1 b. Initially the AGV is open wide enough so that it does not exert pressure on the stomach and therefore does not create a restriction on the flow of food through the stomach. Attached to theAGV 2 is a two directionalrestrictive mechanism 3. Therestrictive mechanism 3 is capable of constricting theAGV 2 as well as relaxing it. Therestrictive mechanism 3 is capable of progressively reducing the inside diameter of theAGV 2, creating a pressure on the stomach so that the diameter of the stomach is reduced and the flow of food through the stomach is restricted. Asensor 4 is capable of sensing the bodily reactions to the start of food ingestion and to send a signal indicating start of eating to acontroller B 5. - The
controller B 5, using analgorithm 5 a, upon receiving the signal of start of eating from thesensor 4, sends a signal to therestrictive mechanism 3 to operate, reduce the diameter of theAGV 2 and create a restriction on food flow. As a result the patient is prevented from eating excessively. After the patient stops eating, thecontroller B 5 sends a signal to the restrictive mechanism to relax and allows thestomach 1 to get back to its original diameter and natural state. Thecontroller B 5 is using thealgorithm 5 a to decide on the time between start of eating and close of theAGV 2, the rate of closing theAGV 2 and the extent to which theAGV 2 is closed. Similarly thecontroller B 5 decides on how long after start of eating theAGV 2 opens, at what rate of opening and to what extent. It is also possible for the sensor to indicate stop of eating for use in deciding when to open theAGV 2 and to what extent. Thealgorithm 5 a can be designed and individually adapted to the patient based on his or her eating habits and anatomy. Thealgorithm 5 a can be modified from outside the body by wireless signals from controller A 9 disposed outside the body tocontroller B 5 inside the body. Also, controller A 9 can receive information fromcontroller B 5 via bi-directional wireless communication to allow the physician to collect data and information on the times of operation of therestrictive mechanism 3. The physician can modify thealgorithm 5 a to allow the patient more or less freedom to eat by changing the time at which therestrictive mechanism 3 starts to operate after the patient starts to eat, the rate of opening, the extent of opening and the time themechanism 3 relaxes theAGV 2, the rate of relaxation and the extent of relaxation. Thecontroller B 5,restrictive mechanism 3 andsensor 4 for start of eating receive electrical power from a power source such as a battery orpower source 6. If needed, such battery can be charged using aremote charger A 8 which inductively transmits energy to charger B 7 for charging such battery. - The
algorithm 5 a preferably includes at least two embodiments as illustrated in the flow charts ofFIGS. 8 and 9 . In the embodiment ofFIG. 8 , thealgorithm 5 a controls theAGV 2 in accordance with an input signal from asensor 4. When there is an input signal from thesensor 4, theAGV 2 is constricted in accordance with stored parameters and the timing of the constriction is stored in the memory of eithercontrollers 5,9. The relaxation of theAGV 2 is also controlled in accordance with the input signal from thesensor 4 and stored parameters. In the embodiment ofFIG. 9 , thealgorithm 5 a controls theAGV 2 in accordance with arbitrary times that are programmed into thecontrollers 5,9. These arbitrary or predetermined times correspond to time periods when food is expected to be ingested. When the arbitrary time occurs, theAGV 2 is constricted in accordance with stored parameters and the timing of the constriction is stored in the memory of eithercontrollers 5,9. The relaxation of theAGV 2 is also controlled in accordance with arbitrary times and stored parameters. If desired the relaxation of theAGV 2 may be delayed by a predetermined time period determined by a physician. The stored parameter are programmed into thecontrollers 5, 9 in accordance with the subroutine illustrated in the flow chart ofFIG. 10 . It is also possible that theAGV 2 may be constricted and relaxed in accordance with input from thesensor 4 and at arbitrary or predetermined times programmed into thecontrollers 5, 9. - The
AGV 2 without therestrictive device 3 is shown inFIG. 2 a andFIG. 2 b. TheAGV 2 is originally made of along strip 10 shown in a top view having a predetermined length and width, made of semi rigid material, with ends 11 and 12 that connect to each other. The connection of the two ends could be with a buckle or a snap-on or other method to form a closed loop for embodiments in which the outer diameter of the AGV stays constant, or could be of a different type connection, such as connecting directly to a motor for other embodiments in which the outside diameter of the AGV changes during operation of the AGV. The length and width ofstrip 10 are approximately 10 cm and 1-5 cm respectively. A side view ofside 13 of theAGV 2 is shown inFIG. 2 b. The inside of thestrip 10 is padded with acushioning material 14 that prevents erosion of the stomach tissue as a result of restricting and relaxing the stomach by theAGV 2. The material can be soft material in one preferred embodiment and could be a balloon filled with liquid or gas in other embodiments. The balloon could be sealed, or could be connected to a source of liquid or gas and a restrictive mechanism inflates or deflates said balloon on demand. - The
AGV 2 is inserted into the body laporascopically, disposed around the stomach and the two ends of thestrip 10 are connected together to create a closed loop, leaving thesoft cushioning portion 14 in contact with the stomach tissue. - The
sensor 4 for start of eating relies on a known clinical fact that the process of start of eating is responsible for a series of bodily actions such as receptive relaxation of the stomach, saliva secretion, chewing, swallowing, secretion of hormones, change in blood glucose level, change in heart rate variability, expansion of the stomach and more. Thesensor 4 for start of eating senses one or more of such bodily actions. In one preferred embodiment the receptive relaxation of the stomach can be sensed by strain gauges attached to the outside of the stomach or by sensing the electrical signals associated with receptive relaxation. Such signals can be measured with electrodes attached to the outside wall of the stomach or by electromagnetic sensors in a way similar to the method of cutaneous Electro Gastro-Graphy (EGG). The electromagnetic sensing can be done inside the body, or can be done cutaneously and the results can be transmitted to controller A 9. - Since the purpose of the artificial
gastric valve 2 is to turn on the system at the initiation of food ingestion, it is preferable to utilize a sensing mechanism that determines that a person has started to swallow food or liquids. As shown inFIG. 7 , thesensor 4 can be placed in the oral cavity and be designed to detect the pressure of mastication or other oral signal. The sensor can also be placed at the level of the esophagus and can be internally placed by endoscopy to sit on the mucousa. Alternatively, thesensor 4 can be placed around the GE junction and detect pressure change, motion, or expansion of this area with the passage of a bolus of food. Thesensor 4 could be placed anyplace within or external to the GI tract, with the purpose of activating a system that either constricts or distends the stomach. - The sensor signal can include an ultrasound, infrared, electrical, radio frequency, magnetic, motion signal, that is directed at the lumen of the stomach or esophagus and initiates the process. For example as food goes through the lumen of the GI tract a signal is sent, and when this is absorbed, deflected or altered by food or luminal contents activates the system. Similarly a reflector could be placed opposite the signal and whenever the reflector is blocked the system is activated. The sensor can be current and voltage measurements on the stomach to measure parameters such as stomach impedance which correlates with start of eating.
- The sensor could be a infrared beam that is combined with spectroscopy to detect a change in tissue perfusion, such as an increase in oxygen saturation which correlates to increased arterial blood flow to the stomach when food arrives at the stomach and it is active.
- The sensor could be other measure of increased blood flow to the stomach or other signal such as temperature change, change in local chemistry, which detect a subtle change in local environment.
- The
sensor 4 could also be placed in the arm or in a combination of places and detect a motion or action that is consistent with bringing food toward the GI tract. Thesensor 4 could detect changes in saliva or other GI tract secretion that is produced with the onset of eating. - Once activated the system can be placed on and constrict the stomach at a steady rate controlled manner to a predetermined level. Alternatively, the
sensor 4 can serve as a gradient and each time the system detects food the constrictor is tightened or an internal system is inflated progressively. - The system controller is equipped with a memory. The purpose is to determine the number of times the system is activated. This information can be used to change speed of constriction or inflation, provide information for clinicians and alter the rate of emptying or any of the parameters of the system. The memory can also store dietary information related to the output of
sensor 4 or other sensors, for example a blood sugar sensor, that are coupled to theinternal controller 5. The memory can function as an internal data base of information and data that can be extracted by a physician utilizing the external controller 9. - In a
preferred embodiment 100 the mechanism for progressive restriction of the stomach is mechanical in nature and acts directly on the AGV to tighten it or release it. Such mechanical action can be done for example by pulling one side of thestrip 10 around the other part or inside the other part by use of a small motor as shown inFIG. 3 . InFIG. 3 the stomach cross section is indicated by 20, the cushioning 21 can be a soft material or a sealed balloon. Asmall motor 23 acts on theAGV 22 to reduce its diameter by pulling or releasing one end of the AGV in relation to the other end of the AGV. - In another
preferred embodiment 200 described inFIG. 4 , the AGV itself does not change in dimensions, only aballoon 36 on the inside of the AGV is changes its volume and pressure. InFIG. 4 the stomach cross section is indicated by 32, the AGV is indicated by 30 with 33 being the connection of the two ends of the AGV. Aballoon 36 is connected to atube 34 having apiston 39 and a mechanism to push liquid through the tube and into saidballoon 36. The inside 31 of theballoon 36 pushes against thestomach 32. The borders of the balloon are indicated by 31 on the inside and 30 on the outside. Theballoon 36 connects to thetube 34 and a piston, and theballoon 36 and thetube 34 are filled with a liquid such as saline solution. Amotor 35 acts on the piston and thereby increases or decreases the pressure in theballoon 36 and therefore increases or decreases the diameter of the AGV on demand in a progressive manner. In another embodiment the pushing can be done by compressing a bellow filled with liquid. - In yet another
embodiment 300 of the restrictive mechanism shown inFIG. 5 , thestomach 41 is encircled with anAGV 42 and aballoon 43 similarly toembodiment 200. Theballoon 43 is filled with liquid, such as saline solution, and is connected via atube 44 to areservoir 45 and apump 46. The pump, controlled by thecontroller B 5, can pump the liquid into the balloon and out of the balloon and increase or decrease the diameter of thestomach 41 to create a progressive restriction on the flow of food and relaxation of the stomach when the patient is not eating. - The system can be designed as a ring, helix or blanket. It could have compartments that are activated at different or the same time. The system could also be placed internally as a bezoar into the stomach anchored by an attachment to the gastric wall. Food would hit the sensor which would cause the inflation of the bezoar causing gastric distension.
- Similar to all the above, rate of inflation and deflation could be altered based on feedback of the system or device history.
Claims (43)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/397,795 US8251888B2 (en) | 2005-04-13 | 2006-04-05 | Artificial gastric valve |
PCT/US2006/013184 WO2006113187A2 (en) | 2005-04-13 | 2006-04-07 | Artificial gastric valve |
CA002604618A CA2604618A1 (en) | 2005-04-13 | 2006-04-07 | Artificial gastric valve |
JP2008506550A JP2008536561A (en) | 2005-04-13 | 2006-04-07 | Artificial gastric valve |
EP06740773A EP1871312A2 (en) | 2005-04-13 | 2006-04-07 | Artificial gastric valve |
AU2006236883A AU2006236883B2 (en) | 2005-04-13 | 2006-04-07 | Artificial gastric valve |
BRPI0608191-6A BRPI0608191A2 (en) | 2005-04-13 | 2006-04-07 | Method for operating a restrictive gastric valve, apparatus for treating overweight and obese patients, device for enhancing the body's natural response to eating, and method for operating a valve for enhancing the body's natural response to eating |
US12/707,920 US8623042B2 (en) | 2005-04-13 | 2010-02-18 | Artificial gastric valve |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67054605P | 2005-04-13 | 2005-04-13 | |
US11/397,795 US8251888B2 (en) | 2005-04-13 | 2006-04-05 | Artificial gastric valve |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/707,920 Division US8623042B2 (en) | 2005-04-13 | 2010-02-18 | Artificial gastric valve |
Publications (2)
Publication Number | Publication Date |
---|---|
US20060235448A1 true US20060235448A1 (en) | 2006-10-19 |
US8251888B2 US8251888B2 (en) | 2012-08-28 |
Family
ID=37109534
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/397,795 Expired - Fee Related US8251888B2 (en) | 2005-04-13 | 2006-04-05 | Artificial gastric valve |
US12/707,920 Expired - Fee Related US8623042B2 (en) | 2005-04-13 | 2010-02-18 | Artificial gastric valve |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/707,920 Expired - Fee Related US8623042B2 (en) | 2005-04-13 | 2010-02-18 | Artificial gastric valve |
Country Status (7)
Country | Link |
---|---|
US (2) | US8251888B2 (en) |
EP (1) | EP1871312A2 (en) |
JP (1) | JP2008536561A (en) |
AU (1) | AU2006236883B2 (en) |
BR (1) | BRPI0608191A2 (en) |
CA (1) | CA2604618A1 (en) |
WO (1) | WO2006113187A2 (en) |
Cited By (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070255336A1 (en) * | 2006-04-28 | 2007-11-01 | Medtronic, Inc. | Gastric constriction device with selectable electrode combinations |
US20070255335A1 (en) * | 2006-04-28 | 2007-11-01 | Medtronic, Inc. | Controller for gastric constriction device with selectable electrode configurations |
US20080221598A1 (en) * | 2007-03-06 | 2008-09-11 | Dlugos Daniel F | Pressure Sensors for Gastric Band and Adjacent Tissue |
US7658196B2 (en) | 2005-02-24 | 2010-02-09 | Ethicon Endo-Surgery, Inc. | System and method for determining implanted device orientation |
US20100152532A1 (en) * | 2007-03-06 | 2010-06-17 | Marcotte Amy L | Gastric Band System with Esophageal Sensor |
US7775215B2 (en) | 2005-02-24 | 2010-08-17 | Ethicon Endo-Surgery, Inc. | System and method for determining implanted device positioning and obtaining pressure data |
US7775966B2 (en) | 2005-02-24 | 2010-08-17 | Ethicon Endo-Surgery, Inc. | Non-invasive pressure measurement in a fluid adjustable restrictive device |
EP2240133A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | Methods and instruments for treating gerd and hiatal hernia |
US20100280304A1 (en) * | 2009-05-04 | 2010-11-04 | Tyco Healthcare Group Lp | Magnetic Gastric Reduction Device |
US7844342B2 (en) | 2008-02-07 | 2010-11-30 | Ethicon Endo-Surgery, Inc. | Powering implantable restriction systems using light |
US7862502B2 (en) | 2006-10-20 | 2011-01-04 | Ellipse Technologies, Inc. | Method and apparatus for adjusting a gastrointestinal restriction device |
US7927270B2 (en) | 2005-02-24 | 2011-04-19 | Ethicon Endo-Surgery, Inc. | External mechanical pressure sensor for gastric band pressure measurements |
US20110137428A1 (en) * | 2008-08-13 | 2011-06-09 | Gad Terliuc | Liner for tubular body portion and apparatus and methods for application thereof |
WO2011097451A1 (en) | 2010-02-05 | 2011-08-11 | Allergan, Inc. | Implantable subcutaneous access port |
WO2011106157A1 (en) | 2010-02-25 | 2011-09-01 | Ethicon Endo-Surgery, Inc. | Devices for treating morbid obesity using hydrogel |
US8016745B2 (en) | 2005-02-24 | 2011-09-13 | Ethicon Endo-Surgery, Inc. | Monitoring of a food intake restriction device |
US8016744B2 (en) | 2005-02-24 | 2011-09-13 | Ethicon Endo-Surgery, Inc. | External pressure-based gastric band adjustment system and method |
US8034065B2 (en) | 2008-02-26 | 2011-10-11 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
WO2011137001A1 (en) | 2010-04-29 | 2011-11-03 | Allergan, Inc. | Self-adjusting gastric band |
WO2011137032A1 (en) | 2010-04-29 | 2011-11-03 | Allergan, Inc. | Self-adjusting mechanical gastric band |
WO2011139505A1 (en) | 2010-04-29 | 2011-11-10 | Allergan, Inc. | Self-adjusting gastric band having various compliant components |
US8057492B2 (en) | 2008-02-12 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Automatically adjusting band system with MEMS pump |
US8066629B2 (en) | 2005-02-24 | 2011-11-29 | Ethicon Endo-Surgery, Inc. | Apparatus for adjustment and sensing of gastric band pressure |
EP2405869A1 (en) * | 2009-01-29 | 2012-01-18 | Milux Holding SA | Obesity treatment |
US8100870B2 (en) | 2007-12-14 | 2012-01-24 | Ethicon Endo-Surgery, Inc. | Adjustable height gastric restriction devices and methods |
US8114345B2 (en) | 2008-02-08 | 2012-02-14 | Ethicon Endo-Surgery, Inc. | System and method of sterilizing an implantable medical device |
US8142452B2 (en) | 2007-12-27 | 2012-03-27 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
US8152710B2 (en) | 2006-04-06 | 2012-04-10 | Ethicon Endo-Surgery, Inc. | Physiological parameter analysis for an implantable restriction device and a data logger |
US8187162B2 (en) | 2008-03-06 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Reorientation port |
US8187163B2 (en) | 2007-12-10 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Methods for implanting a gastric restriction device |
US8192350B2 (en) | 2008-01-28 | 2012-06-05 | Ethicon Endo-Surgery, Inc. | Methods and devices for measuring impedance in a gastric restriction system |
WO2012091929A1 (en) * | 2010-12-29 | 2012-07-05 | Ethicon Endo-Surgery, Inc. | Obesity therapy and heart rate variability |
US8221439B2 (en) | 2008-02-07 | 2012-07-17 | Ethicon Endo-Surgery, Inc. | Powering implantable restriction systems using kinetic motion |
US8233995B2 (en) | 2008-03-06 | 2012-07-31 | Ethicon Endo-Surgery, Inc. | System and method of aligning an implantable antenna |
US8236023B2 (en) | 2004-03-18 | 2012-08-07 | Allergan, Inc. | Apparatus and method for volume adjustment of intragastric balloons |
US8246533B2 (en) | 2006-10-20 | 2012-08-21 | Ellipse Technologies, Inc. | Implant system with resonant-driven actuator |
WO2012110623A1 (en) | 2011-02-17 | 2012-08-23 | Allergan Medical Sàrl | Hydraulic gastric band with reversible self-opening mechanism |
WO2012125698A1 (en) | 2011-03-16 | 2012-09-20 | Allergan, Inc. | Self-adjusting gastric band having various compliant components and/or satiety booster |
WO2012142214A1 (en) | 2011-04-13 | 2012-10-18 | Allergan, Inc. | Syringe-based leak detection system |
US8308630B2 (en) | 2006-01-04 | 2012-11-13 | Allergan, Inc. | Hydraulic gastric band with collapsible reservoir |
WO2012154819A2 (en) | 2011-05-10 | 2012-11-15 | Allergan, Inc. | Directionless (orientation independent) needle injection port |
US8317677B2 (en) | 2008-10-06 | 2012-11-27 | Allergan, Inc. | Mechanical gastric band with cushions |
US8337389B2 (en) | 2008-01-28 | 2012-12-25 | Ethicon Endo-Surgery, Inc. | Methods and devices for diagnosing performance of a gastric restriction system |
US8377079B2 (en) | 2007-12-27 | 2013-02-19 | Ethicon Endo-Surgery, Inc. | Constant force mechanisms for regulating restriction devices |
US8377081B2 (en) | 2004-03-08 | 2013-02-19 | Allergan, Inc. | Closure system for tubular organs |
US8382780B2 (en) | 2002-08-28 | 2013-02-26 | Allergan, Inc. | Fatigue-resistant gastric banding device |
WO2013028760A2 (en) | 2011-08-25 | 2013-02-28 | Allergan, Inc. | Implantable access port with mesh attachment rivets |
US8398654B2 (en) | 2008-04-17 | 2013-03-19 | Allergan, Inc. | Implantable access port device and attachment system |
US8409221B2 (en) | 2008-04-17 | 2013-04-02 | Allergan, Inc. | Implantable access port device having a safety cap |
WO2013059419A2 (en) | 2011-10-20 | 2013-04-25 | Allergan, Inc. | Implantable injection port |
WO2013074342A1 (en) | 2011-11-15 | 2013-05-23 | Allergan, Inc. | Interior needle stick guard stems for tubes |
WO2013074343A1 (en) | 2011-11-16 | 2013-05-23 | Allergan, Inc. | Pre-loaded septum for use with an access port |
WO2013086136A1 (en) | 2011-12-07 | 2013-06-13 | Allergan, Inc. | Tube connector with a guiding tip |
WO2013112442A1 (en) | 2012-01-23 | 2013-08-01 | Allergan, Inc. | Gastric bands for reducing obstructions |
US8506532B2 (en) | 2009-08-26 | 2013-08-13 | Allergan, Inc. | System including access port and applicator tool |
US8517915B2 (en) | 2010-06-10 | 2013-08-27 | Allergan, Inc. | Remotely adjustable gastric banding system |
US8591395B2 (en) | 2008-01-28 | 2013-11-26 | Ethicon Endo-Surgery, Inc. | Gastric restriction device data handling devices and methods |
US8591532B2 (en) | 2008-02-12 | 2013-11-26 | Ethicon Endo-Sugery, Inc. | Automatically adjusting band system |
CN103429197A (en) * | 2010-12-29 | 2013-12-04 | 伊西康内外科公司 | Obesity therapy and heart rate variability |
US8623042B2 (en) | 2005-04-13 | 2014-01-07 | Mitchell Roslin | Artificial gastric valve |
US8678993B2 (en) | 2010-02-12 | 2014-03-25 | Apollo Endosurgery, Inc. | Remotely adjustable gastric banding system |
US8696616B2 (en) | 2010-12-29 | 2014-04-15 | Ethicon Endo-Surgery, Inc. | Obesity therapy and heart rate variability |
US8698373B2 (en) | 2010-08-18 | 2014-04-15 | Apollo Endosurgery, Inc. | Pare piezo power with energy recovery |
US8708979B2 (en) | 2009-08-26 | 2014-04-29 | Apollo Endosurgery, Inc. | Implantable coupling device |
US8715158B2 (en) | 2009-08-26 | 2014-05-06 | Apollo Endosurgery, Inc. | Implantable bottom exit port |
US8758221B2 (en) | 2010-02-24 | 2014-06-24 | Apollo Endosurgery, Inc. | Source reservoir with potential energy for remotely adjustable gastric banding system |
US8764624B2 (en) | 2010-02-25 | 2014-07-01 | Apollo Endosurgery, Inc. | Inductively powered remotely adjustable gastric banding system |
US8840594B2 (en) | 2009-06-18 | 2014-09-23 | Department Of Biotechnology, Ministry Of Science And Technology, Government Of India | Device for collecting fecal discharge in incontinent patients |
US8840541B2 (en) | 2010-02-25 | 2014-09-23 | Apollo Endosurgery, Inc. | Pressure sensing gastric banding system |
US8845513B2 (en) | 2002-08-13 | 2014-09-30 | Apollo Endosurgery, Inc. | Remotely adjustable gastric banding device |
US8870742B2 (en) | 2006-04-06 | 2014-10-28 | Ethicon Endo-Surgery, Inc. | GUI for an implantable restriction device and a data logger |
US8882655B2 (en) | 2010-09-14 | 2014-11-11 | Apollo Endosurgery, Inc. | Implantable access port system |
US8882728B2 (en) | 2010-02-10 | 2014-11-11 | Apollo Endosurgery, Inc. | Implantable injection port |
US8900118B2 (en) | 2008-10-22 | 2014-12-02 | Apollo Endosurgery, Inc. | Dome and screw valves for remotely adjustable gastric banding systems |
US8900117B2 (en) | 2004-01-23 | 2014-12-02 | Apollo Endosurgery, Inc. | Releasably-securable one-piece adjustable gastric band |
US8905916B2 (en) | 2010-08-16 | 2014-12-09 | Apollo Endosurgery, Inc. | Implantable access port system |
US8905915B2 (en) | 2006-01-04 | 2014-12-09 | Apollo Endosurgery, Inc. | Self-regulating gastric band with pressure data processing |
US8939888B2 (en) | 2010-04-28 | 2015-01-27 | Apollo Endosurgery, Inc. | Method and system for determining the pressure of a fluid in a syringe, an access port, a catheter, and a gastric band |
US8961393B2 (en) | 2010-11-15 | 2015-02-24 | Apollo Endosurgery, Inc. | Gastric band devices and drive systems |
US8961394B2 (en) | 2011-12-20 | 2015-02-24 | Apollo Endosurgery, Inc. | Self-sealing fluid joint for use with a gastric band |
US8992415B2 (en) | 2010-04-30 | 2015-03-31 | Apollo Endosurgery, Inc. | Implantable device to protect tubing from puncture |
US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
US9044298B2 (en) | 2010-04-29 | 2015-06-02 | Apollo Endosurgery, Inc. | Self-adjusting gastric band |
US9050165B2 (en) | 2010-09-07 | 2015-06-09 | Apollo Endosurgery, Inc. | Remotely adjustable gastric banding system |
US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
US9125718B2 (en) | 2010-04-30 | 2015-09-08 | Apollo Endosurgery, Inc. | Electronically enhanced access port for a fluid filled implant |
US9168000B2 (en) | 2013-03-13 | 2015-10-27 | Ethicon Endo-Surgery, Inc. | Meal detection devices and methods |
US9192501B2 (en) | 2010-04-30 | 2015-11-24 | Apollo Endosurgery, Inc. | Remotely powered remotely adjustable gastric band system |
US9211207B2 (en) | 2010-08-18 | 2015-12-15 | Apollo Endosurgery, Inc. | Power regulated implant |
US9226840B2 (en) | 2010-06-03 | 2016-01-05 | Apollo Endosurgery, Inc. | Magnetically coupled implantable pump system and method |
US9265422B2 (en) | 2010-04-27 | 2016-02-23 | Apollo Endosurgery, Inc. | System and method for determining an adjustment to a gastric band based on satiety state data and weight loss data |
CN105393100A (en) * | 2013-05-21 | 2016-03-09 | 优罗曼姆斯公司 | Method and device for detecting a slow leak in an implantable hydraulic occlusion system |
US9295573B2 (en) | 2010-04-29 | 2016-03-29 | Apollo Endosurgery, Inc. | Self-adjusting gastric band having various compliant components and/or a satiety booster |
US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
EP2456487A4 (en) * | 2009-07-23 | 2017-05-17 | ReShape Medical, Inc. | Inflation and deflation mechanisms for inflatable medical devices |
EP3058327A4 (en) * | 2013-10-17 | 2017-05-31 | Innovative Pressure Testing LLC | System and method for a benchmark pressure test |
US9668900B2 (en) | 2002-05-09 | 2017-06-06 | Reshape Medical, Inc. | Balloon system and methods for treating obesity |
US9962276B2 (en) | 2005-10-31 | 2018-05-08 | Reshape Medical Llc | Intragastric space filler |
US9987470B2 (en) | 2009-07-23 | 2018-06-05 | ReShape Medical, LLC | Deflation and removal of implantable medical devices |
US10024752B2 (en) | 2009-08-18 | 2018-07-17 | Innovative Pressure Testing, Llc | System and method for detecting leaks |
US10117766B2 (en) | 2010-04-06 | 2018-11-06 | Reshape Medical Llc | Inflation devices for intragastric devices with improved attachment and detachment and associated systems and methods |
US10301930B2 (en) | 2013-10-17 | 2019-05-28 | Innovative Pressure Testing, Llc | System and method for a benchmark pressure test |
AU2017254825B2 (en) * | 2008-01-29 | 2019-10-31 | Implantica Patent Ltd | A Device, System and Method for Treating Obesity |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7955357B2 (en) | 2004-07-02 | 2011-06-07 | Ellipse Technologies, Inc. | Expandable rod system to treat scoliosis and method of using the same |
AT502985B1 (en) * | 2005-12-22 | 2009-05-15 | Lechner Wolfgang Dr | SYSTEM FOR CONTROLLING A CONTROLLABLE MAGNETIC STRIP |
US20090112262A1 (en) | 2007-10-30 | 2009-04-30 | Scott Pool | Skeletal manipulation system |
US11202707B2 (en) | 2008-03-25 | 2021-12-21 | Nuvasive Specialized Orthopedics, Inc. | Adjustable implant system |
US8382756B2 (en) | 2008-11-10 | 2013-02-26 | Ellipse Technologies, Inc. | External adjustment device for distraction device |
US8197490B2 (en) | 2009-02-23 | 2012-06-12 | Ellipse Technologies, Inc. | Non-invasive adjustable distraction system |
US9622792B2 (en) | 2009-04-29 | 2017-04-18 | Nuvasive Specialized Orthopedics, Inc. | Interspinous process device and method |
US9248043B2 (en) | 2010-06-30 | 2016-02-02 | Ellipse Technologies, Inc. | External adjustment device for distraction device |
US8734488B2 (en) | 2010-08-09 | 2014-05-27 | Ellipse Technologies, Inc. | Maintenance feature in magnetic implant |
WO2012045030A2 (en) * | 2010-10-01 | 2012-04-05 | Intrapace, Inc. | Feedback systems and methods to enhance obstructive and other obesity treatments, optionally using multiple sensors |
US20120316451A1 (en) * | 2010-12-08 | 2012-12-13 | Intrapace, Inc. | Event Evaluation Using Heart Rate Variation for Ingestion Monitoring and Therapy |
WO2012112396A2 (en) | 2011-02-14 | 2012-08-23 | Ellipse Technologies, Inc. | Device and method for treating fractured bones |
US10743794B2 (en) | 2011-10-04 | 2020-08-18 | Nuvasive Specialized Orthopedics, Inc. | Devices and methods for non-invasive implant length sensing |
WO2013066946A1 (en) | 2011-11-01 | 2013-05-10 | Ellipse Technologies, Inc. | Adjustable magnetic devices and methods of using same |
AU2013338218B2 (en) | 2012-10-29 | 2017-05-04 | Nuvasive Specialized Orthopedics, Inc. | Adjustable devices for treating arthritis of the knee |
US10751094B2 (en) | 2013-10-10 | 2020-08-25 | Nuvasive Specialized Orthopedics, Inc. | Adjustable spinal implant |
AU2015253313B9 (en) | 2014-04-28 | 2020-09-10 | Nuvasive Specialized Orthopedics, Inc. | System for informational magnetic feedback in adjustable implants |
WO2016105524A1 (en) | 2014-12-26 | 2016-06-30 | Ellipse Technologies, Inc. | Systems and methods for distraction |
WO2016134326A2 (en) | 2015-02-19 | 2016-08-25 | Nuvasive, Inc. | Systems and methods for vertebral adjustment |
CN113425401A (en) | 2015-10-16 | 2021-09-24 | 诺威适骨科专科公司 | Adjustable device for treating gonitis |
WO2017100774A1 (en) | 2015-12-10 | 2017-06-15 | Nuvasive Specialized Orthopedics, Inc. | External adjustment device for distraction device |
ES2805657T3 (en) | 2016-01-28 | 2021-02-15 | Nuvasive Specialized Orthopedics Inc | Systems for bone transport |
US11207173B2 (en) * | 2018-09-11 | 2021-12-28 | Lucian Popescu | Adaptive lower esophagus sphincter augmentation |
Citations (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1174814A (en) * | 1915-09-17 | 1916-03-07 | Manville E J Machine Co | Automatic threader. |
US1999683A (en) * | 1933-12-01 | 1935-04-30 | Helge A Borresen | Hose clamp |
US2163048A (en) * | 1937-02-13 | 1939-06-20 | Mckee Brothers Corp | Band clamp |
US2339138A (en) * | 1942-09-18 | 1944-01-11 | Central Equipment Co | Clamp |
US2405667A (en) * | 1944-01-20 | 1946-08-13 | Ottesen Andrew | Receptacle cover |
US2438231A (en) * | 1946-01-18 | 1948-03-23 | Schultz | Closure for fountain pens and the like |
US2635907A (en) * | 1950-11-13 | 1953-04-21 | Brummer Mfg Corp | Seal for shafts |
US2714469A (en) * | 1954-11-24 | 1955-08-02 | Emery Carpenter Container Comp | Locking ring construction |
US2936980A (en) * | 1954-10-01 | 1960-05-17 | Illinois Tool Works | Cable strap |
US3189961A (en) * | 1963-09-17 | 1965-06-22 | Rotron Mfg Co | Hose clamp |
US3667081A (en) * | 1969-11-03 | 1972-06-06 | Bosch Gmbh Robert | Window-cleaning arrangement |
US3955834A (en) * | 1972-02-11 | 1976-05-11 | Aktiebolaget Svenska Flaktfabriken | Apparatus for connecting ducts with a self-sealing joint |
US4133315A (en) * | 1976-12-27 | 1979-01-09 | Berman Edward J | Method and apparatus for reducing obesity |
US4157713A (en) * | 1977-05-11 | 1979-06-12 | Clarey Michael T | Air-pressure splint |
US4271827A (en) * | 1979-09-13 | 1981-06-09 | Angelchik Jean P | Method for prevention of gastro esophageal reflux |
US4399809A (en) * | 1979-10-30 | 1983-08-23 | Baro Juan V | Artificial sphincter for use at stoma, or for the like purposes |
US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
US4442153A (en) * | 1980-12-19 | 1984-04-10 | Siemens Aktiengesellschaft | Longitudinally divided cable sleeve of thermo-plastic synthetic material with a shape memory |
US4492004A (en) * | 1982-12-03 | 1985-01-08 | Hans Oetiker | Earless clamp structure |
US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4582640A (en) * | 1982-03-08 | 1986-04-15 | Collagen Corporation | Injectable cross-linked collagen implant material |
US4592339A (en) * | 1985-06-12 | 1986-06-03 | Mentor Corporation | Gastric banding device |
US4592355A (en) * | 1983-01-28 | 1986-06-03 | Eliahu Antebi | Process for tying live tissue and an instrument for performing the tying operation |
US4601713A (en) * | 1985-06-11 | 1986-07-22 | Genus Catheter Technologies, Inc. | Variable diameter catheter |
US4671351A (en) * | 1985-07-17 | 1987-06-09 | Vertech Treatment Systems, Inc. | Fluid treatment apparatus and heat exchanger |
US4753086A (en) * | 1986-01-13 | 1988-06-28 | Schmidt Kenneth J | Costume jewelry circlet |
US4760837A (en) * | 1987-02-19 | 1988-08-02 | Inamed Development Company | Apparatus for verifying the position of needle tip within the injection reservoir of an implantable medical device |
US4803075A (en) * | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
US4925446A (en) * | 1988-07-06 | 1990-05-15 | Transpharm Group Inc. | Removable inflatable intragastrointestinal device for delivering beneficial agents |
US4944487A (en) * | 1989-05-08 | 1990-07-31 | Lee Company | Diaphragm valve |
US4944659A (en) * | 1987-01-27 | 1990-07-31 | Kabivitrum Ab | Implantable piezoelectric pump system |
US4994019A (en) * | 1989-07-28 | 1991-02-19 | Micro-Magnetics, Inc. | Magnetic occluding device |
US5084061A (en) * | 1987-09-25 | 1992-01-28 | Gau Fred C | Intragastric balloon with improved valve locating means |
US5091171A (en) * | 1986-12-23 | 1992-02-25 | Yu Ruey J | Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use |
US5120313A (en) * | 1986-03-28 | 1992-06-09 | Nancy W. Elftman | Method for measuring blood pressure in an animal or human using a percutaneous access port |
US5188609A (en) * | 1991-07-08 | 1993-02-23 | Bryman Medical Inc. | Swivel clip medical tube holder |
US5224494A (en) * | 1992-03-19 | 1993-07-06 | Enhorning Goran E | Vaginal pessary |
US5226429A (en) * | 1991-06-20 | 1993-07-13 | Inamed Development Co. | Laparoscopic gastric band and method |
US5326349A (en) * | 1992-07-09 | 1994-07-05 | Baraff David R | Artificial larynx |
US5391156A (en) * | 1992-06-30 | 1995-02-21 | Ethicon, Inc. | Flexible encoscopic surgical port |
US5399351A (en) * | 1990-07-09 | 1995-03-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
US5509888A (en) * | 1994-07-26 | 1996-04-23 | Conceptek Corporation | Controller valve device and method |
US5531716A (en) * | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
US5535752A (en) * | 1995-02-27 | 1996-07-16 | Medtronic, Inc. | Implantable capacitive absolute pressure and temperature monitor system |
US5601604A (en) * | 1993-05-27 | 1997-02-11 | Inamed Development Co. | Universal gastric band |
US5607418A (en) * | 1995-08-22 | 1997-03-04 | Illinois Institute Of Technology | Implantable drug delivery apparatus |
US5633001A (en) * | 1993-03-19 | 1997-05-27 | Medinvent | Composition and a method for tissue augmentation |
US5653718A (en) * | 1994-05-16 | 1997-08-05 | Yoon; Inbae | Cannula anchoring system |
US5658298A (en) * | 1993-11-09 | 1997-08-19 | Inamed Development Company | Laparoscopic tool |
US5704893A (en) * | 1994-07-11 | 1998-01-06 | Dacomed Corportion | Vessel occlusive apparatus and method |
US5713911A (en) * | 1996-10-03 | 1998-02-03 | United States Surgical Corporation | Surgical clip |
US5748200A (en) * | 1995-03-23 | 1998-05-05 | Fuji Photo Film Co., Ltd. | Image displaying apparatus |
US5766232A (en) * | 1996-05-10 | 1998-06-16 | Medtronic, Inc. | Method and apparatus for altering the Q of an implantable medical device telemetry antenna |
US5769877A (en) * | 1995-01-04 | 1998-06-23 | Plexus, Inc. | High value capacitive, replenishable power source |
US5785295A (en) * | 1996-08-27 | 1998-07-28 | Industrial Technology Research Institute | Thermally buckling control microvalve |
US5861014A (en) * | 1997-04-30 | 1999-01-19 | Medtronic, Inc. | Method and apparatus for sensing a stimulating gastrointestinal tract on-demand |
USRE36176E (en) * | 1993-02-18 | 1999-03-30 | Kuzmak; Lubomyr I. | Laparoscopic adjustable gastric banding device and method for implantation and removal thereof |
US5904697A (en) * | 1995-02-24 | 1999-05-18 | Heartport, Inc. | Devices and methods for performing a vascular anastomosis |
US5910149A (en) * | 1998-04-29 | 1999-06-08 | Kuzmak; Lubomyr I. | Non-slipping gastric band |
US5928195A (en) * | 1996-01-31 | 1999-07-27 | Malamud; Daniel | Remote control drug delivery device |
US5938669A (en) * | 1997-05-07 | 1999-08-17 | Klasamed S.A. | Adjustable gastric banding device for contracting a patient's stomach |
US5944751A (en) * | 1993-09-17 | 1999-08-31 | Zertl Medical, Inc. | Vibratory heart valve |
US5944696A (en) * | 1996-06-03 | 1999-08-31 | Bayless; William Brian | Swivel clip medical tube holder |
US6013679A (en) * | 1989-08-01 | 2000-01-11 | Anika Research, Inc. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
US6024340A (en) * | 1996-12-04 | 2000-02-15 | Active Control Experts, Inc. | Valve assembly |
US6024704A (en) * | 1998-04-30 | 2000-02-15 | Medtronic, Inc | Implantable medical device for sensing absolute blood pressure and barometric pressure |
US6048309A (en) * | 1996-03-04 | 2000-04-11 | Heartport, Inc. | Soft tissue retractor and delivery device therefor |
US6067991A (en) * | 1998-08-13 | 2000-05-30 | Forsell; Peter | Mechanical food intake restriction device |
US6074341A (en) * | 1998-06-09 | 2000-06-13 | Timm Medical Technologies, Inc. | Vessel occlusive apparatus and method |
US20020072780A1 (en) * | 2000-09-26 | 2002-06-13 | Transneuronix, Inc. | Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity |
US20020091395A1 (en) * | 2001-01-08 | 2002-07-11 | Shlomo Gabbay | System to inhibit and/or control expansion of anatomical features |
US20020098097A1 (en) * | 2001-01-22 | 2002-07-25 | Angad Singh | Magnetically-actuated micropump |
US20030019498A1 (en) * | 1998-08-13 | 2003-01-30 | Obtech Medical Ag. | Non-injection port food intake restriction device |
US20030066536A1 (en) * | 1999-08-12 | 2003-04-10 | Obtech Medical Ag | Controlled food intake restriction |
US6676674B1 (en) * | 1999-03-17 | 2004-01-13 | Moshe Dudai | Gastric band |
US20040044332A1 (en) * | 2000-11-03 | 2004-03-04 | Nikolaus Stergiopulos | Implantable medical device for delivering a liquid |
US20040059393A1 (en) * | 2001-01-05 | 2004-03-25 | Shai Policker | Regulation of eating habits |
US20040133219A1 (en) * | 2002-07-29 | 2004-07-08 | Peter Forsell | Multi-material constriction device for forming stoma opening |
US20040148034A1 (en) * | 2002-11-01 | 2004-07-29 | Jonathan Kagan | Apparatus and methods for treatment of morbid obesity |
US20040147816A1 (en) * | 2001-04-18 | 2004-07-29 | Shai Policker | Analysis of eating habits |
US20050038484A1 (en) * | 2003-02-03 | 2005-02-17 | Enteromedics, Inc. | Controlled vagal blockage therapy |
US20050055039A1 (en) * | 2003-07-28 | 2005-03-10 | Polymorfix, Inc. | Devices and methods for pyloric anchoring |
US20050119674A1 (en) * | 2003-10-23 | 2005-06-02 | Peter Gingras | Gastric constriction device |
US20050131485A1 (en) * | 2003-02-03 | 2005-06-16 | Enteromedics, Inc. | High frequency vagal blockage therapy |
US20050143766A1 (en) * | 2002-09-04 | 2005-06-30 | Endoart Sa | Telemetrically controlled band for regulating functioning of a body organ or duct, and methods of making, implantation and use |
US20050143765A1 (en) * | 2002-09-04 | 2005-06-30 | Endoart Sa | Telemetrically controlled band for regulating functioning of a body organ or duct, and methods of making, implantation and use |
US20060020298A1 (en) * | 2004-07-20 | 2006-01-26 | Camilleri Michael L | Systems and methods for curbing appetite |
US7017583B2 (en) * | 1999-08-12 | 2006-03-28 | Peter Forsell | Food intake restriction with controlled wireless energy supply |
US20060074473A1 (en) * | 2004-03-23 | 2006-04-06 | Michael Gertner | Methods and devices for combined gastric restriction and electrical stimulation |
US20060089571A1 (en) * | 2004-03-23 | 2006-04-27 | Michael Gertner | Obesity treatment systems |
US7160312B2 (en) * | 1999-06-25 | 2007-01-09 | Usgi Medical, Inc. | Implantable artificial partition and methods of use |
US7390294B2 (en) * | 2004-05-28 | 2008-06-24 | Ethicon Endo-Surgery, Inc. | Piezo electrically driven bellows infuser for hydraulically controlling an adjustable gastric band |
US20090082793A1 (en) * | 2004-01-23 | 2009-03-26 | Allergan, Inc. | Releasably-securable one-piece adjustable gastric band |
US20100010291A1 (en) * | 2008-07-14 | 2010-01-14 | Allergan, Inc. | Implantable pump system with calibration |
US20100100079A1 (en) * | 2008-10-21 | 2010-04-22 | General Electric Company | Implantable device system |
US7896787B2 (en) * | 2008-09-05 | 2011-03-01 | Michael Adam LaSala | Health and fitness device |
US8034065B2 (en) * | 2008-02-26 | 2011-10-11 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
US8057492B2 (en) * | 2008-02-12 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Automatically adjusting band system with MEMS pump |
Family Cites Families (363)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US55039A (en) | 1866-05-29 | Improved method of preserving and storing carbonic-acid gas | ||
US148034A (en) | 1874-03-03 | Improvement in wine and cider presses | ||
US11543A (en) | 1854-08-15 | Winnower | ||
US91395A (en) | 1869-06-15 | whittingham | ||
US1830947A (en) | 1927-04-18 | 1931-11-10 | Edward L Klingel | Ground clamp |
US3059645A (en) | 1960-11-28 | 1962-10-23 | Paul A Hasbrouck | Adjustable clamp |
NL128220C (en) * | 1963-05-06 | 1900-01-01 | ||
SE344275B (en) | 1966-02-10 | 1972-04-10 | R Gruenert | |
FR1566202A (en) | 1967-12-27 | 1969-05-09 | ||
CA949965A (en) | 1971-12-03 | 1974-06-25 | Robert H. Marchessault | Method of preparing cross-linked starch and starch derivatives |
US3840018A (en) | 1973-01-31 | 1974-10-08 | M Heifetz | Clamp for occluding tubular conduits in the human body |
US4053176A (en) | 1975-10-15 | 1977-10-11 | West Chester Chemical Co., Inc. | Collar for sealing pipe joints |
US4118805A (en) | 1977-02-28 | 1978-10-10 | Codman & Shurtleff, Inc. | Artificial sphincter |
DE2721548C2 (en) | 1977-05-13 | 1982-11-04 | Friedrich Gerd 5000 Köln Lauterjung | probe |
US4176412A (en) | 1978-09-15 | 1979-12-04 | The Kendall Company | Urine collection device |
US4340083A (en) | 1978-11-30 | 1982-07-20 | Carleton Controls Corporation | Deflectable beam valve |
US4299012A (en) | 1979-05-08 | 1981-11-10 | Hans Oetiker | Hose clamp |
DK13881A (en) | 1981-01-14 | 1982-07-15 | O G Nien | PROCEDURE AND APPARATUS FOR DEFINITION INFLUENCE AND LEAVE OF A FOREIGN SUBSTANCE IN HUMAN BAG |
US4417567A (en) | 1981-08-12 | 1983-11-29 | Medical Engineering Corporation | Artificial sphincter |
US4408597A (en) | 1982-04-23 | 1983-10-11 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Prosthetic occlusive device for an internal passageway |
US4485805A (en) | 1982-08-24 | 1984-12-04 | Gunther Pacific Limited Of Hong Kong | Weight loss device and method |
US4450375A (en) | 1982-11-12 | 1984-05-22 | Kiwi Coders Corporation | Piezoelectric fluid control device |
US4551862A (en) | 1982-12-15 | 1985-11-12 | Haber Terry M | Prosthetic sphincter |
US4558699A (en) | 1983-01-03 | 1985-12-17 | Bashour Samuel B | Method of and apparatus for restricting the passage of food through the stomach |
DE3309788C2 (en) | 1983-03-18 | 1985-12-05 | Karl Dr. 6301 Pohlheim Aigner | Implantable injection catheter |
SE445967B (en) | 1983-10-25 | 1986-08-04 | Romanowski Richard | DEVICE FOR ASTAD COMBINING AND MAINTENANCE OF LIQUID AND GAS SAFETY AREAS IN BODY PARTS AND / OR FOR ASTAD COMMUNICATION OF BODIES AND / OR FOR MECHANICAL FIXING OF BODY PARTS |
US4559699A (en) | 1984-06-08 | 1985-12-24 | Westinghouse Electric Corp. | Method of constructing a padmounted distribution transformer |
SE442820B (en) | 1984-06-08 | 1986-02-03 | Pharmacia Ab | GEL OF THE CROSS-BOND HYALURONIC ACID FOR USE AS A GLASS BODY SUBSTITUTE |
SE456346B (en) | 1984-07-23 | 1988-09-26 | Pharmacia Ab | GEL TO PREVENT ADHESION BETWEEN BODY TISSUE AND SET FOR ITS PREPARATION |
US4881939A (en) | 1985-02-19 | 1989-11-21 | The Johns Hopkins University | Implantable helical cuff |
SE449430B (en) | 1985-06-25 | 1987-05-04 | Per Fredlund | Prosthesis for treatment of obesity |
US4696288A (en) | 1985-08-14 | 1987-09-29 | Kuzmak Lubomyr I | Calibrating apparatus and method of using same for gastric banding surgery |
US4710174A (en) | 1985-12-16 | 1987-12-01 | Surgical Engineering Associates, Inc. | Implantable infusion port |
US4694827A (en) | 1986-01-14 | 1987-09-22 | Weiner Brian C | Inflatable gastric device for treating obesity and method of using the same |
US4693695A (en) | 1986-03-31 | 1987-09-15 | Cheng Peter S C | Ascending and descending balloon action toy |
US4708140A (en) | 1986-05-08 | 1987-11-24 | Baron Howard C | Atraumatic vascular balloon clamp |
JPS6382961A (en) | 1986-09-17 | 1988-04-13 | 品川商工株式会社 | Bundling tool |
US5385938B1 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
DE3862797D1 (en) | 1987-04-22 | 1991-06-20 | Siemens Ag | PISTON PUMP FOR A MEDICINE DOSING DEVICE. |
FR2623167B2 (en) | 1987-08-14 | 1992-08-07 | Genus Int | IMPROVEMENT IN ARTICLES WITH ELASTIC ARTICULATIONS RIGIDIFYING ON THEIR TENSIONING |
US4915690A (en) | 1988-02-02 | 1990-04-10 | C. R. Bard, Inc. | Micro-injection port |
US4969899A (en) | 1989-03-08 | 1990-11-13 | Cox-Uphoff International | Inflatable implant |
US5045060A (en) | 1989-04-26 | 1991-09-03 | Therex Corp. | Implantable infusion device |
EP0416250A3 (en) | 1989-08-01 | 1991-08-28 | The Research Foundation Of State University Of New York | N-acylurea and o-acylisourea derivatives of hyaluronic acid |
US5116652A (en) | 1989-10-13 | 1992-05-26 | Abbott Laboratories | Kink-resistant medical tubing and catheters |
SE464558B (en) | 1990-03-22 | 1991-05-13 | Hepar Ab | IMPLANTABLE DEVICE FOR SUSPENSION OF A CHANNEL IN THE BODY OF A LIVE BEING |
US5143724A (en) | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
US5074868A (en) | 1990-08-03 | 1991-12-24 | Inamed Development Company | Reversible stoma-adjustable gastric band |
JP3115625B2 (en) | 1991-03-30 | 2000-12-11 | 帝國製薬株式会社 | Topical patch containing lidocaine |
US5458568A (en) | 1991-05-24 | 1995-10-17 | Cortrak Medical, Inc. | Porous balloon for selective dilatation and drug delivery |
AT396392B (en) | 1991-09-30 | 1993-08-25 | Hoerbiger Fluidtechnik Gmbh | PIEZO VALVE |
US5360445A (en) | 1991-11-06 | 1994-11-01 | International Business Machines Corporation | Blood pump actuator |
US5160338A (en) | 1991-11-13 | 1992-11-03 | Inamed Development Co. | Device for removing implantable articles |
US5259399A (en) | 1992-03-02 | 1993-11-09 | Alan Brown | Device and method of causing weight loss using removable variable volume intragastric bladder |
FR2688693A1 (en) | 1992-03-19 | 1993-09-24 | Ferriere Xavier | Artificial sphincter, especially urethral (urinary) sphincter |
US5246456A (en) | 1992-06-08 | 1993-09-21 | Wilkinson Lawrence H | Fenestrated gastric pouch |
DE4219888C2 (en) | 1992-06-17 | 2003-01-02 | Storz Endoskop Gmbh Schaffhaus | Medical pressure transducer |
DE4225524C2 (en) | 1992-08-01 | 1994-08-04 | Fresenius Ag | Implantable infusion device |
US5676651A (en) | 1992-08-06 | 1997-10-14 | Electric Boat Corporation | Surgically implantable pump arrangement and method for pumping body fluids |
US5972000A (en) | 1992-11-13 | 1999-10-26 | Influence Medical Technologies, Ltd. | Non-linear anchor inserter device and bone anchors |
DE69322370C5 (en) | 1993-02-18 | 2009-01-08 | Ethicon Endo-Surgery, Inc., Cincinnati | Laparoscopic adjustable gastric band |
JP3105702B2 (en) | 1993-06-11 | 2000-11-06 | レーザーテック株式会社 | Optical defect inspection equipment |
SE9303319D0 (en) | 1993-10-11 | 1993-10-11 | Gambro Ab | Methods of calculating and / or controlling flows for a certain period of time through a peristaltic pump and a monitor adapted to practice this method |
US5762599A (en) | 1994-05-02 | 1998-06-09 | Influence Medical Technologies, Ltd. | Magnetically-coupled implantable medical devices |
US5449363A (en) | 1994-05-06 | 1995-09-12 | Browne Medical Systems, Inc. | Endoscopic lithotripsy system |
DE4417927B4 (en) | 1994-05-19 | 2005-02-03 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Telemetry device, in particular for a tissue stimulator system |
US5562714A (en) | 1995-02-03 | 1996-10-08 | Medtronic, Inc. | Magnetic field strength regulator for implant |
US5695504A (en) | 1995-02-24 | 1997-12-09 | Heartport, Inc. | Devices and methods for performing a vascular anastomosis |
US6102922A (en) | 1995-09-22 | 2000-08-15 | Kirk Promotions Limited | Surgical method and device for reducing the food intake of patient |
US5833698A (en) | 1996-07-23 | 1998-11-10 | United States Surgical Corporation | Anastomosis instrument and method |
IT1287967B1 (en) | 1996-10-17 | 1998-09-10 | Fidia Spa In Amministrazione S | PHARMACEUTICAL PREPARATIONS FOR LOCAL ANESTHETIC USE |
US7204832B2 (en) * | 1996-12-02 | 2007-04-17 | Pálomar Medical Technologies, Inc. | Cooling system for a photo cosmetic device |
FR2759577B1 (en) | 1997-02-17 | 1999-08-06 | Corneal Ind | DEEP SCLERECTOMY IMPLANT |
FR2759576B1 (en) | 1997-02-17 | 1999-08-06 | Corneal Ind | PRE-DESCEMETIC SCLERO-KERATECTOMY IMPLANT |
JP3274384B2 (en) | 1997-03-31 | 2002-04-15 | 株式会社パイオラックス | Indwelling catheter and its insertion device |
DE69723955D1 (en) | 1997-04-04 | 2003-09-11 | Christian Peclat | Peristaltic pump |
US6391336B1 (en) | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
US6090131A (en) | 1997-09-25 | 2000-07-18 | Daley; Robert J. | Bioabsorbable staples |
FR2769491B1 (en) | 1997-10-15 | 2000-01-07 | Patrick Sangouard | ADJUSTABLE ARTIFICIAL SPHINCTER WITH MAGNETIC CONTROL |
NL1007349C2 (en) | 1997-10-24 | 1999-04-27 | Suyker Wilhelmus Joseph Leonardus | System for the mechanical production of anastomoses between hollow structures; as well as device and applicator for use therewith. |
US5993473A (en) | 1997-11-19 | 1999-11-30 | Chan; Yung C. | Expandable body device for the gastric cavity and method |
US6193734B1 (en) | 1998-01-23 | 2001-02-27 | Heartport, Inc. | System for performing vascular anastomoses |
US6203523B1 (en) | 1998-02-02 | 2001-03-20 | Medtronic Inc | Implantable drug infusion device having a flow regulator |
US7647237B2 (en) | 1998-04-29 | 2010-01-12 | Minimed, Inc. | Communication station and software for interfacing with an infusion pump, analyte monitor, analyte meter, or the like |
US6601604B1 (en) | 1998-05-08 | 2003-08-05 | Michael S. Cooper | Fire-control sprinkler system |
US6113609A (en) | 1998-05-26 | 2000-09-05 | Scimed Life Systems, Inc. | Implantable tissue fastener and system for treating gastroesophageal reflux disease |
GB9811398D0 (en) | 1998-05-27 | 1998-07-22 | Pbt Limited | Spool valve |
FR2780730B1 (en) | 1998-07-01 | 2000-10-13 | Corneal Ind | INJECTABLE BIPHASIC COMPOSITIONS, ESPECIALLY USEFUL IN RESTORATIVE AND AESTHETIC SURGERIES |
US6221024B1 (en) | 1998-07-20 | 2001-04-24 | Medtronic, Inc. | Implantable pressure sensor and method of fabrication |
US6210347B1 (en) | 1998-08-13 | 2001-04-03 | Peter Forsell | Remote control food intake restriction device |
FR2783153B1 (en) | 1998-09-14 | 2000-12-01 | Jerome Dargent | GASTRIC CONSTRICTION DEVICE |
US6306088B1 (en) | 1998-10-03 | 2001-10-23 | Individual Monitoring Systems, Inc. | Ambulatory distributed recorders system for diagnosing medical disorders |
US6024755A (en) | 1998-12-11 | 2000-02-15 | Embol-X, Inc. | Suture-free clamp and sealing port and methods of use |
DK172900B1 (en) | 1998-12-18 | 1999-09-27 | Per Julius Nielsen | Preparation and kit for use in intraocular surgery |
WO2004112563A2 (en) * | 2003-06-20 | 2004-12-29 | Metacure N.V., | Gastrointestinal methods and apparatus for use in treating disorders |
US6635049B1 (en) | 1999-04-30 | 2003-10-21 | Medtronic, Inc. | Drug bolus delivery system |
US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
US20050192629A1 (en) * | 1999-06-25 | 2005-09-01 | Usgi Medical Inc. | Methods and apparatus for creating and regulating a gastric stoma |
DE19931990C1 (en) | 1999-07-09 | 2001-01-11 | Festo Ag & Co | Solenoid valve |
EP1072282A1 (en) | 1999-07-19 | 2001-01-31 | EndoArt S.A. | Flow control device |
FR2797181B1 (en) | 1999-08-05 | 2002-05-03 | Richard Cancel | REMOTE GASTRIC BAND DEVICE FOR FORMING A RESTRICTED STOMA OPENING IN THE ESTOMAC |
MXPA02001217A (en) * | 1999-08-12 | 2004-05-21 | Potencia Medical Ag | Stoma opening forming apparatus. |
US6454701B1 (en) | 1999-08-12 | 2002-09-24 | Obtech Medical Ag | Heartburn and reflux disease treatment apparatus with energy transfer device |
US6464628B1 (en) | 1999-08-12 | 2002-10-15 | Obtech Medical Ag | Mechanical anal incontinence |
US6453907B1 (en) | 1999-08-12 | 2002-09-24 | Obtech Medical Ag | Food intake restriction with energy transfer device |
US6482145B1 (en) | 2000-02-14 | 2002-11-19 | Obtech Medical Ag | Hydraulic anal incontinence treatment |
FR2799118B1 (en) | 1999-10-01 | 2002-07-12 | Medical Innovation Dev | ADJUSTABLE GASTRIC IMPLANT |
US6210345B1 (en) | 1999-10-04 | 2001-04-03 | American Biosystems, Inc. | Outcome measuring airway resistance diagnostic system |
IL132635A0 (en) | 1999-10-28 | 2001-03-19 | Niti Alloys Tech Ltd | Shape memory alloy clip and method of use thereof |
IT1315260B1 (en) | 1999-12-07 | 2003-02-03 | Valerio Cigaina | REMOVABLE GASTRIC BANDAGE |
US20030208212A1 (en) | 1999-12-07 | 2003-11-06 | Valerio Cigaina | Removable gastric band |
FR2802407B1 (en) | 1999-12-21 | 2002-12-13 | Rc Medical | DESERRABLE GASTROPLASTY RING |
FR2804011B1 (en) | 2000-01-20 | 2002-07-19 | Rc Medical | SINGLE CONTROL GASTROPLASTY RING |
US7204821B1 (en) | 2000-01-31 | 2007-04-17 | Ethicon, Inc. | Surgical fluid management system with suction control |
US6454700B1 (en) | 2000-02-09 | 2002-09-24 | Obtech Medical Ag | Heartburn and reflux disease treatment apparatus with wireless energy supply |
US6463935B1 (en) | 2000-02-10 | 2002-10-15 | Obtech Medical Ag | Controlled heartburn and reflux disease treatment |
US6470892B1 (en) | 2000-02-10 | 2002-10-29 | Obtech Medical Ag | Mechanical heartburn and reflux treatment |
US6450946B1 (en) | 2000-02-11 | 2002-09-17 | Obtech Medical Ag | Food intake restriction with wireless energy transfer |
US6475136B1 (en) | 2000-02-14 | 2002-11-05 | Obtech Medical Ag | Hydraulic heartburn and reflux treatment |
MXPA00001922A (en) | 2000-02-24 | 2002-03-08 | De Hayos Garza Andres | Percutaneous intra-gastric balloon catheter for obesity treatment. |
FR2805986B1 (en) | 2000-03-13 | 2002-10-11 | Districlass Madical | INTRA-GASTRIC DEVICE WITH VARIABLE VOLUME |
US6691047B1 (en) | 2000-03-16 | 2004-02-10 | Aksys, Ltd. | Calibration of pumps, such as blood pumps of dialysis machine |
KR20010096388A (en) | 2000-04-19 | 2001-11-07 | 진세훈 | Human glans enhancing materials and glans enhancing method |
FR2808674B1 (en) | 2000-05-12 | 2002-08-02 | Cie Euro Etude Rech Paroscopie | GASTROPLASTY RING WITH GRIPPED LEGS |
US20030191433A1 (en) | 2000-05-31 | 2003-10-09 | Prentiss John Gilbert | Breast pump |
US6419696B1 (en) | 2000-07-06 | 2002-07-16 | Paul A. Spence | Annuloplasty devices and related heart valve repair methods |
FR2811996B1 (en) | 2000-07-19 | 2003-08-08 | Corneal Ind | CROSS-LINKING OF POLYSACCHARIDE (S), PREPARATION OF HYDROGEL (S); POLYSACCHARIDE (S) AND HYDROGEL (S) OBTAINED, THEIR USES |
US6685668B1 (en) | 2000-07-31 | 2004-02-03 | Abbott Laboratories | Closed-loop IV fluid flow control |
JP4240779B2 (en) | 2000-07-31 | 2009-03-18 | ソニー株式会社 | LCD projector and adjustment method |
FR2813786B1 (en) | 2000-09-11 | 2003-03-14 | Medical Innovation Dev | METHOD AND DEVICE FOR CONTROLLING THE INFLATION OF AN INFLATABLE PROSTHETIC BODY AND PROSTHESIS USING THE SAME |
US6432040B1 (en) | 2000-09-14 | 2002-08-13 | Nizam N. Meah | Implantable esophageal sphincter apparatus for gastroesophageal reflux disease and method |
US7198250B2 (en) | 2000-09-18 | 2007-04-03 | Par Technologies, Llc | Piezoelectric actuator and pump using same |
US6527701B1 (en) | 2000-09-29 | 2003-03-04 | Precision Medical Devices, Inc. | Body fluid flow control device |
US6924273B2 (en) | 2000-10-03 | 2005-08-02 | Scott W. Pierce | Chondroprotective/restorative compositions and methods of use thereof |
US6871090B1 (en) | 2000-10-13 | 2005-03-22 | Advanced Bionics Corporation | Switching regulator for implantable spinal cord stimulation |
US6615084B1 (en) | 2000-11-15 | 2003-09-02 | Transneuronix, Inc. | Process for electrostimulation treatment of morbid obesity |
US6579301B1 (en) | 2000-11-17 | 2003-06-17 | Syntheon, Llc | Intragastric balloon device adapted to be repeatedly varied in volume without external assistance |
FR2816828B1 (en) | 2000-11-23 | 2004-10-22 | Richard Cancel | DEVICE FOR THE REMOTE IMPLEMENTATION AND WITHOUT A MATERIAL LINK OF AN IMPLANT AND IMPLANT IMPLEMENTED BY THIS DEVICE |
US6609025B2 (en) | 2001-01-02 | 2003-08-19 | Cyberonics, Inc. | Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation |
US20020103430A1 (en) | 2001-01-29 | 2002-08-01 | Hastings Roger N. | Catheter navigation within an MR imaging device |
US6474584B2 (en) | 2001-02-20 | 2002-11-05 | Faruk Ekich | Fly tying method and apparatus |
EP1234554A1 (en) | 2001-02-21 | 2002-08-28 | EndoArt SA | Vascular graft with internal deflector |
US7119062B1 (en) | 2001-02-23 | 2006-10-10 | Neucoll, Inc. | Methods and compositions for improved articular surgery using collagen |
US6513403B2 (en) | 2001-04-03 | 2003-02-04 | Cray Inc. | Flexible drive rod for access to enclosed locations |
US6889086B2 (en) | 2001-04-06 | 2005-05-03 | Cardiac Pacemakers, Inc. | Passive telemetry system for implantable medical device |
JP4761698B2 (en) | 2001-04-17 | 2011-08-31 | 日本碍子株式会社 | Method for producing molded body and molding core |
FR2823663B1 (en) | 2001-04-18 | 2004-01-02 | Cousin Biotech | DEVICE FOR TREATING MORBID OBESITY |
US20050227936A1 (en) | 2001-05-18 | 2005-10-13 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA) |
FR2825264B1 (en) | 2001-06-01 | 2004-04-02 | Surgical Diffusion | GASTROPLASTY RING |
WO2003000314A2 (en) | 2001-06-20 | 2003-01-03 | The Regents Of The University Of California | Hemodialysis system and method |
US6511490B2 (en) | 2001-06-22 | 2003-01-28 | Antoine Jean Henri Robert | Gastric banding device and method |
US6457801B1 (en) | 2001-06-27 | 2002-10-01 | Lexmark International, Inc. | Method and apparatus for measuring ink dry time |
IL159624A0 (en) | 2001-06-29 | 2004-06-01 | Medgraft Microtech Inc | Biodegradable injectable implants and related methods of manufacture and use |
DE10139857B4 (en) | 2001-08-14 | 2009-09-10 | Robert Bosch Gmbh | Valve for controlling fluids |
US6629988B2 (en) | 2001-08-28 | 2003-10-07 | Ethicon, Inc. | Composite staple for completing an anastomosis |
US6754527B2 (en) | 2001-09-06 | 2004-06-22 | Medtronic, Inc. | System and method for reducing noise in an implantable medical device |
US6770067B2 (en) | 2001-09-07 | 2004-08-03 | Medtronic Minimed, Inc. | Infusion device and driving mechanism for same |
US6796004B2 (en) | 2001-09-14 | 2004-09-28 | Donaldson Company, Inc. | Exhaust system clamp |
US20030060873A1 (en) | 2001-09-19 | 2003-03-27 | Nanomedical Technologies, Inc. | Metallic structures incorporating bioactive materials and methods for creating the same |
US6632239B2 (en) | 2001-10-02 | 2003-10-14 | Spiration, Inc. | Constriction device including reinforced suture holes |
US6659937B2 (en) | 2001-10-11 | 2003-12-09 | M. Sheldon Polsky | Continent bladder access device |
FR2834443B1 (en) | 2002-01-09 | 2004-04-02 | Sofradim Production | GASTRIC RING OF TREATMENT OF OBESITY |
WO2003058067A1 (en) | 2002-01-10 | 2003-07-17 | Interacoustics A/S | Piezo electric pump and device with such pump |
FR2834631B1 (en) | 2002-01-15 | 2004-10-22 | Cie Euro Etude Rech Paroscopie | GASTROPLASTY RING IN VARIABLE HARDNESS ELASTOMERIC MATERIAL |
US7544177B2 (en) | 2002-01-24 | 2009-06-09 | The Regents Of The University Of California | Aerosol device to deliver bioactive agent |
EP1343112A1 (en) | 2002-03-08 | 2003-09-10 | EndoArt S.A. | Implantable device |
US20030181890A1 (en) | 2002-03-22 | 2003-09-25 | Schulze Dale R. | Medical device that removably attaches to a bodily organ |
US7040349B2 (en) | 2002-03-27 | 2006-05-09 | Viking Technologies, L.C. | Piezo-electric actuated multi-valve manifold |
ATE335152T1 (en) | 2002-03-28 | 2006-08-15 | Fluid Automation Syst | ELECTROMAGNETIC VALVE |
ATE271670T1 (en) | 2002-05-31 | 2004-08-15 | Festo Ag & Co | PIEZO VALVE |
FR2840193B1 (en) | 2002-05-31 | 2005-02-11 | Textile Hi Tec | GASTRIC BAND |
US7338433B2 (en) | 2002-08-13 | 2008-03-04 | Allergan, Inc. | Remotely adjustable gastric banding method |
EP1534162B1 (en) | 2002-08-13 | 2012-04-04 | Allergan, Inc. | Remotely adjustable gastric banding device |
EP1389453B1 (en) | 2002-08-16 | 2007-03-07 | AMI Agency for Medical Innovations GmbH | Band to produce an artificial reduction in the gastrointestinal tract |
DE60331457D1 (en) | 2002-08-28 | 2010-04-08 | Allergan Inc | TEMPTING MAGNETIC BANDING DEVICE |
DE60221828T2 (en) | 2002-09-04 | 2008-05-08 | Endoart S.A. | Surgical ring with remote control device for reversible diameter changes |
EP1396242B1 (en) | 2002-09-04 | 2007-11-14 | Endoart S.A. | Closure system for surgical ring |
US7216648B2 (en) | 2002-09-06 | 2007-05-15 | Apneon, Inc. | Systems and methods for moving and/or restraining tissue in the upper respiratory system |
DE10246340A1 (en) | 2002-10-04 | 2004-04-29 | Wohlrab, David, Dr. | Combination preparation of hyaluronic acid and at least one local anesthetic and its use |
US20040106899A1 (en) | 2002-11-30 | 2004-06-03 | Mcmichael Donald J. | Gastric balloon catheter with improved balloon orientation |
GB2396484A (en) | 2002-12-19 | 2004-06-23 | Nokia Corp | Reducing coupling between different antennas |
US6940467B2 (en) | 2003-01-10 | 2005-09-06 | Atmel Germany Gmbh | Circuit arrangement and method for deriving electrical power from an electromagnetic field |
FR2861734B1 (en) | 2003-04-10 | 2006-04-14 | Corneal Ind | CROSSLINKING OF LOW AND HIGH MOLECULAR MASS POLYSACCHARIDES; PREPARATION OF INJECTABLE SINGLE PHASE HYDROGELS; POLYSACCHARIDES AND HYDROGELS OBTAINED |
US20050038498A1 (en) | 2003-04-17 | 2005-02-17 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
AT413477B (en) | 2003-06-04 | 2006-03-15 | Ami Gmbh | DEVICE FOR GENERATING ARTIFICIAL FENCING IN THE GASTRO-INTESTINAL TRACT |
AT413475B (en) | 2003-06-04 | 2006-03-15 | Ami Gmbh | DEVICE FOR GENERATING ARTIFICIAL FENCING IN THE GASTRO-INTESTINAL TRACT |
FR2855744B1 (en) | 2003-06-04 | 2006-04-14 | Cie Euro Etude Rech Paroscopie | SURGICAL RING WITH IMPROVED CLOSURE SYSTEM |
AT413476B (en) | 2003-06-04 | 2006-03-15 | Ami Gmbh | DEVICE FOR GENERATING ARTIFICIAL FENCING IN THE GASTRO-INTESTINAL TRACT |
US7862546B2 (en) | 2003-06-16 | 2011-01-04 | Ethicon Endo-Surgery, Inc. | Subcutaneous self attaching injection port with integral moveable retention members |
US8029477B2 (en) | 2003-12-19 | 2011-10-04 | Ethicon Endo-Surgery, Inc. | Applier with safety for implantable medical device |
US7374557B2 (en) | 2003-06-16 | 2008-05-20 | Ethicon Endo-Surgery, Inc. | Subcutaneous self attaching injection port with integral fasteners |
DK1638638T3 (en) | 2003-06-20 | 2009-11-23 | Allergan Inc | Two-way Wearing Valve |
US7951067B2 (en) | 2003-06-27 | 2011-05-31 | Ethicon Endo-Surgery, Inc. | Implantable band having improved attachment mechanism |
ATE447384T1 (en) | 2003-06-27 | 2009-11-15 | Ethicon Endo Surgery Inc | IMPLANTABLE BAND HAVING A CONNECTION DEVICE COMPRISED OF MATERIALS WITH DIFFERENT MATERIAL PROPERTIES |
US20040267291A1 (en) | 2003-06-27 | 2004-12-30 | Byrum Randal T. | Implantable band with non-mechanical attachment mechanism |
US20040267292A1 (en) | 2003-06-27 | 2004-12-30 | Byrum Randal T. | Implantable band with transverse attachment mechanism |
US7500944B2 (en) | 2003-06-27 | 2009-03-10 | Ethicon Endo-Surgery, Inc. | Implantable band with attachment mechanism |
US20050002984A1 (en) | 2003-06-27 | 2005-01-06 | Byrum Randal T. | Implantable band with attachment mechanism having dissimilar material properties |
JP4960700B2 (en) * | 2003-07-21 | 2012-06-27 | メタキュアー リミティド | Gastrointestinal treatment method and apparatus for use in treating disease and controlling blood glucose |
ATE401848T1 (en) | 2003-07-25 | 2008-08-15 | Wolfgang Lechner | CONTROLLABLE GASTRIC BAND |
US20060246137A1 (en) | 2003-07-30 | 2006-11-02 | Laurence Hermitte | Complex matrix for biomedical use |
US7263405B2 (en) | 2003-08-27 | 2007-08-28 | Neuro And Cardiac Technologies Llc | System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities |
US20050070937A1 (en) | 2003-09-30 | 2005-03-31 | Jambor Kristin L. | Segmented gastric band |
US7608086B2 (en) | 2003-09-30 | 2009-10-27 | Ethicon Endo-Surgery, Inc. | Anastomosis wire ring device |
US7144400B2 (en) | 2003-10-01 | 2006-12-05 | Ethicon Endo-Surgery, Inc. | Gastric band introduction device |
KR100529496B1 (en) | 2003-10-17 | 2005-11-21 | 현대모비스 주식회사 | Passenger air bag system of vehicle |
US7054690B2 (en) | 2003-10-22 | 2006-05-30 | Intrapace, Inc. | Gastrointestinal stimulation device |
US7299082B2 (en) * | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
US20050100779A1 (en) | 2003-11-07 | 2005-05-12 | Gertner Michael E. | Three dimensional polymeric fuel cell components |
US20050131383A1 (en) | 2003-12-16 | 2005-06-16 | How-Lun Chen | Method for implanting flexible injection port |
AU2004235622A1 (en) | 2003-12-17 | 2005-07-07 | Ethicon Endo-Surgery, Inc. | Mechanically adjustable gastric band |
US8124120B2 (en) | 2003-12-22 | 2012-02-28 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
EP1701981B1 (en) | 2003-12-30 | 2017-06-07 | Genzyme Corporation | Cohesive gels from cross-linked hyaluronan and/or hylan,their preparation and use |
US7177693B2 (en) | 2004-01-07 | 2007-02-13 | Medtronic, Inc. | Gastric stimulation for altered perception to treat obesity |
US20050171568A1 (en) | 2004-01-30 | 2005-08-04 | Niall Duffy | Catheter and guidewire exchange system with improved catheter design |
US7594885B2 (en) | 2004-02-20 | 2009-09-29 | Ethicon Endo-Surgery, Inc. | Method for implanting an adjustable band |
US7311716B2 (en) | 2004-02-20 | 2007-12-25 | Ethicon Endo-Surgery, Inc. | Surgically implantable adjustable band having a flat profile when implanted |
AU2005218318A1 (en) | 2004-02-27 | 2005-09-15 | Ethicon Endo-Surgery, Inc | Methods and devices for reducing hollow organ volume |
ES2333024T3 (en) | 2004-03-08 | 2010-02-16 | Allergan Medical S.A. | CLOSURE SYSTEM FOR TUBULAR ORGANS. |
US20060142790A1 (en) | 2004-03-23 | 2006-06-29 | Michael Gertner | Methods and devices to facilitate connections between body lumens |
US20070233170A1 (en) | 2004-03-23 | 2007-10-04 | Michael Gertner | Extragastric Balloon |
US20050228415A1 (en) | 2004-03-23 | 2005-10-13 | Michael Gertner | Methods and devices for percutaneous, non-laparoscopic treatment of obesity |
US20060264699A1 (en) | 2004-10-27 | 2006-11-23 | Michael Gertner | Extragastric minimally invasive methods and devices to treat obesity |
US8343031B2 (en) | 2004-03-23 | 2013-01-01 | Michael Gertner | Obesity treatment systems |
US20080147002A1 (en) | 2004-03-23 | 2008-06-19 | Michael Eric Gertner | Obesity treatment systems |
US20080071306A1 (en) | 2004-03-23 | 2008-03-20 | Michael Gertner | Extragastric Balloon With Attachment Tabs |
US8001976B2 (en) | 2004-03-23 | 2011-08-23 | Michael Gertner | Management systems for the surgically treated obese patient |
US7946976B2 (en) | 2004-03-23 | 2011-05-24 | Michael Gertner | Methods and devices for the surgical creation of satiety and biofeedback pathways |
US20080300618A1 (en) | 2004-03-23 | 2008-12-04 | Michael Eric Gertner | Obesity treatment systems |
US20060195139A1 (en) | 2004-03-23 | 2006-08-31 | Michael Gertner | Extragastric devices and methods for gastroplasty |
US7841978B2 (en) | 2004-03-23 | 2010-11-30 | Michael Gertner | Methods and devices for to treatment of obesity |
AU2005231323B2 (en) | 2004-03-26 | 2011-03-31 | Ethicon Endo-Surgery, Inc | Systems and methods for treating obesity |
US20050226936A1 (en) | 2004-04-08 | 2005-10-13 | Q-Med Ab | Method of soft tissue augmentation |
US20050240155A1 (en) | 2004-04-27 | 2005-10-27 | Conlon Sean P | Surgically implantable injection port having a centered catheter connection tube |
US20050240156A1 (en) | 2004-04-27 | 2005-10-27 | Conlon Sean P | Method of implanting a fluid injection port |
US7484940B2 (en) | 2004-04-28 | 2009-02-03 | Kinetic Ceramics, Inc. | Piezoelectric fluid pump |
ES2609105T3 (en) | 2004-05-20 | 2017-04-18 | Mentor Worldwide Llc | Covalent linking method of hyaluronic acid and chitosan |
US7351240B2 (en) | 2004-05-28 | 2008-04-01 | Ethicon Endo—Srugery, Inc. | Thermodynamically driven reversible infuser pump for use as a remotely controlled gastric band |
US7374565B2 (en) | 2004-05-28 | 2008-05-20 | Ethicon Endo-Surgery, Inc. | Bi-directional infuser pump with volume braking for hydraulically controlling an adjustable gastric band |
US7481763B2 (en) | 2004-05-28 | 2009-01-27 | Ethicon Endo-Surgery, Inc. | Metal bellows position feedback for hydraulic control of an adjustable gastric band |
US20050277899A1 (en) | 2004-06-01 | 2005-12-15 | Conlon Sean P | Method of implanting a fluid injection port |
US7351198B2 (en) | 2004-06-02 | 2008-04-01 | Ethicon Endo-Surgery, Inc. | Implantable adjustable sphincter system |
US20050288740A1 (en) | 2004-06-24 | 2005-12-29 | Ethicon Endo-Surgery, Inc. | Low frequency transcutaneous telemetry to implanted medical device |
US7191007B2 (en) | 2004-06-24 | 2007-03-13 | Ethicon Endo-Surgery, Inc | Spatially decoupled twin secondary coils for optimizing transcutaneous energy transfer (TET) power transfer characteristics |
US20050288739A1 (en) | 2004-06-24 | 2005-12-29 | Ethicon, Inc. | Medical implant having closed loop transcutaneous energy transfer (TET) power transfer regulation circuitry |
US7599743B2 (en) | 2004-06-24 | 2009-10-06 | Ethicon Endo-Surgery, Inc. | Low frequency transcutaneous energy transfer to implanted medical device |
US7599744B2 (en) | 2004-06-24 | 2009-10-06 | Ethicon Endo-Surgery, Inc. | Transcutaneous energy transfer primary coil with a high aspect ferrite core |
WO2006055052A2 (en) | 2004-07-19 | 2006-05-26 | Michael Gertner | Methods and devices for chronic embolic protection |
US20060041183A1 (en) | 2004-08-20 | 2006-02-23 | Massen Richard J | Electromechanical machine-based artificial muscles, bio-valves and related devices |
US7776061B2 (en) | 2004-09-28 | 2010-08-17 | Garner Dean L | Fluid adjustable band |
EP1799119A4 (en) | 2004-09-30 | 2010-11-17 | Duocure Inc | Device and method for treating weight disorders |
US20070078476A1 (en) | 2004-10-12 | 2007-04-05 | Hull Wendell C Sr | Overweight control apparatuses for insertion into the stomach |
EP1804888B1 (en) | 2004-10-15 | 2013-12-25 | Bfkw, Llc | Bariatric device |
US7775966B2 (en) | 2005-02-24 | 2010-08-17 | Ethicon Endo-Surgery, Inc. | Non-invasive pressure measurement in a fluid adjustable restrictive device |
US7601162B2 (en) | 2005-01-14 | 2009-10-13 | Ethicon Endo-Surgery, Inc. | Actuator for an implantable band |
US7879068B2 (en) | 2005-01-14 | 2011-02-01 | Ethicon Endo-Surgery, Inc. | Feedback sensing for a mechanical restrictive device |
US7771382B2 (en) | 2005-01-19 | 2010-08-10 | Gi Dynamics, Inc. | Resistive anti-obesity devices |
US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
US20060173238A1 (en) * | 2005-01-31 | 2006-08-03 | Starkebaum Warren L | Dynamically controlled gastric occlusion device |
US20060173424A1 (en) | 2005-02-01 | 2006-08-03 | Conlon Sean P | Surgically implantable injection port having an absorbable fastener |
US7771439B2 (en) | 2005-02-04 | 2010-08-10 | Symmetry Medical New Bedford Inc | Gastric band insertion instrument |
US20060252983A1 (en) | 2005-02-11 | 2006-11-09 | Lembo Nicholas J | Dynamically adjustable gastric implants and methods of treating obesity using dynamically adjustable gastric implants |
US7699770B2 (en) | 2005-02-24 | 2010-04-20 | Ethicon Endo-Surgery, Inc. | Device for non-invasive measurement of fluid pressure in an adjustable restriction device |
US7927270B2 (en) | 2005-02-24 | 2011-04-19 | Ethicon Endo-Surgery, Inc. | External mechanical pressure sensor for gastric band pressure measurements |
US7775215B2 (en) | 2005-02-24 | 2010-08-17 | Ethicon Endo-Surgery, Inc. | System and method for determining implanted device positioning and obtaining pressure data |
US7658196B2 (en) | 2005-02-24 | 2010-02-09 | Ethicon Endo-Surgery, Inc. | System and method for determining implanted device orientation |
US8066629B2 (en) | 2005-02-24 | 2011-11-29 | Ethicon Endo-Surgery, Inc. | Apparatus for adjustment and sensing of gastric band pressure |
US7909754B2 (en) | 2005-02-24 | 2011-03-22 | Ethicon Endo-Surgery, Inc. | Non-invasive measurement of fluid pressure in an adjustable gastric band |
US20080009680A1 (en) | 2005-06-24 | 2008-01-10 | Hassler William L Jr | Remote monitoring and adjustment of a food intake restriction device |
US8016744B2 (en) | 2005-02-24 | 2011-09-13 | Ethicon Endo-Surgery, Inc. | External pressure-based gastric band adjustment system and method |
US7712470B2 (en) | 2005-03-19 | 2010-05-11 | Michael Gertner | Devices with integral magnets and uses thereof |
WO2006107901A1 (en) | 2005-04-04 | 2006-10-12 | Micardia Corporation | Dynamic reinforcement of the lower esophageal sphincter |
AT501281B8 (en) | 2005-04-11 | 2007-02-15 | Wolfgang Dr Lechner | TAXABLE MAGNETIC BAND |
US8251888B2 (en) | 2005-04-13 | 2012-08-28 | Mitchell Steven Roslin | Artificial gastric valve |
US7899540B2 (en) | 2005-04-29 | 2011-03-01 | Cyberonics, Inc. | Noninvasively adjustable gastric band |
US7310557B2 (en) | 2005-04-29 | 2007-12-18 | Maschino Steven E | Identification of electrodes for nerve stimulation in the treatment of eating disorders |
US7727141B2 (en) | 2005-05-04 | 2010-06-01 | Ethicon Endo-Surgery, Inc. | Magnetic resonance imaging (MRI) safe remotely adjustable artifical sphincter |
CA2611963A1 (en) | 2005-05-10 | 2007-06-14 | Michael Gertner | Obesity treatment systems |
WO2006122183A2 (en) | 2005-05-10 | 2006-11-16 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
US7918844B2 (en) | 2005-06-24 | 2011-04-05 | Ethicon Endo-Surgery, Inc. | Applier for implantable medical device |
US7021147B1 (en) | 2005-07-11 | 2006-04-04 | General Electric Company | Sensor package and method |
US20070016262A1 (en) | 2005-07-13 | 2007-01-18 | Betastim, Ltd. | Gi and pancreatic device for treating obesity and diabetes |
US7364542B2 (en) | 2005-07-15 | 2008-04-29 | Ethicon Endo-Surgery, Inc. | Gastric band suture tab extender |
US7615001B2 (en) | 2005-07-15 | 2009-11-10 | Ethicon Endo-Surgery, Inc. | Precurved gastric band |
US7416528B2 (en) | 2005-07-15 | 2008-08-26 | Ethicon Endo-Surgery, Inc. | Latching device for gastric band |
US20070015955A1 (en) | 2005-07-15 | 2007-01-18 | Mark Tsonton | Accordion-like gastric band |
US7618365B2 (en) | 2005-07-15 | 2009-11-17 | Ethicon Endo-Surgery, Inc. | Method of implating a medical device using a suture tab extender |
US7367937B2 (en) | 2005-07-15 | 2008-05-06 | Ethicon Endo-Surgey, Inc. | Gastric band |
US8298133B2 (en) | 2005-07-15 | 2012-10-30 | Ethicon Endo-Surgery, Inc. | Gastric band composed of different hardness materials |
US8182411B2 (en) | 2005-07-15 | 2012-05-22 | Ethicon Endo-Surgery, Inc. | Gastric band with mating end profiles |
US7766815B2 (en) | 2005-07-28 | 2010-08-03 | Ethicon Endo-Surgery, Inc. | Electroactive polymer actuated gastric band |
WO2007017880A2 (en) | 2005-08-11 | 2007-02-15 | Stimplant Ltd. | Implantable device for obesity prevention |
US7240607B2 (en) | 2005-08-23 | 2007-07-10 | Polygon Company | Removable end plug |
JP2009510168A (en) | 2005-10-03 | 2009-03-12 | マーク エー. ピンスカイ | Compositions and methods for improved skin care |
EP1779821A1 (en) | 2005-10-26 | 2007-05-02 | Etervind AB | Adjustable gastric band |
US7246734B2 (en) | 2005-12-05 | 2007-07-24 | Ethicon Endo-Surgery, Inc. | Rotary hydraulic pump actuated multi-stroke surgical instrument |
AT502985B1 (en) | 2005-12-22 | 2009-05-15 | Lechner Wolfgang Dr | SYSTEM FOR CONTROLLING A CONTROLLABLE MAGNETIC STRIP |
US8043206B2 (en) | 2006-01-04 | 2011-10-25 | Allergan, Inc. | Self-regulating gastric band with pressure data processing |
US7798954B2 (en) | 2006-01-04 | 2010-09-21 | Allergan, Inc. | Hydraulic gastric band with collapsible reservoir |
US20070265646A1 (en) | 2006-01-17 | 2007-11-15 | Ellipse Technologies, Inc. | Dynamically adjustable gastric implants |
US7762999B2 (en) | 2006-02-01 | 2010-07-27 | Ethicon Endo-Surgery, Inc. | Injection port |
US20070185373A1 (en) | 2006-02-03 | 2007-08-09 | Ethicon Endo-Surgery, Inc. | Gastric band introduction device |
WO2007104356A1 (en) | 2006-03-13 | 2007-09-20 | Rudolf Steffen | Adaptive device and adaptive method for adapting the stomach opening of a patient |
US7794386B2 (en) | 2006-03-15 | 2010-09-14 | Allergan, Inc. | Methods for facilitating weight loss |
WO2007114905A2 (en) | 2006-04-04 | 2007-10-11 | Gem Biosystems, Inc. | Pericardial inserts and methods of use |
US8152710B2 (en) | 2006-04-06 | 2012-04-10 | Ethicon Endo-Surgery, Inc. | Physiological parameter analysis for an implantable restriction device and a data logger |
US8870742B2 (en) | 2006-04-06 | 2014-10-28 | Ethicon Endo-Surgery, Inc. | GUI for an implantable restriction device and a data logger |
US20080249806A1 (en) | 2006-04-06 | 2008-10-09 | Ethicon Endo-Surgery, Inc | Data Analysis for an Implantable Restriction Device and a Data Logger |
US20080250341A1 (en) | 2006-04-06 | 2008-10-09 | Ethicon Endo-Surgery, Inc. | Gui With Trend Analysis for an Implantable Restriction Device and a Data Logger |
US20070243227A1 (en) | 2006-04-14 | 2007-10-18 | Michael Gertner | Coatings for surgical staplers |
US20070255336A1 (en) | 2006-04-28 | 2007-11-01 | Medtronic, Inc. | Gastric constriction device with selectable electrode combinations |
US20070255335A1 (en) | 2006-04-28 | 2007-11-01 | Medtronic, Inc. | Controller for gastric constriction device with selectable electrode configurations |
US7763039B2 (en) | 2006-06-09 | 2010-07-27 | Ethicon Endo-Surgery, Inc. | Articulating blunt dissector/gastric band application device |
US20070298005A1 (en) | 2006-06-22 | 2007-12-27 | Marie-Josee Thibault | Injectable composition for treatment of skin defects or deformations |
AT504158B1 (en) | 2006-08-21 | 2008-09-15 | Ami Gmbh | DEVICE FOR TREATING FATIBILITY |
US20080319435A1 (en) | 2006-10-12 | 2008-12-25 | Boston Scientific Scimed, Inc. | Shape-changing tissue constrictor and methods of use |
US8246533B2 (en) | 2006-10-20 | 2012-08-21 | Ellipse Technologies, Inc. | Implant system with resonant-driven actuator |
US7862502B2 (en) | 2006-10-20 | 2011-01-04 | Ellipse Technologies, Inc. | Method and apparatus for adjusting a gastrointestinal restriction device |
AU2007317340B2 (en) | 2006-11-03 | 2011-12-08 | Gep Technology, Inc. | Apparatus and methods for minimally invasive obesity treatment |
US20080161875A1 (en) | 2006-11-21 | 2008-07-03 | Stone Robert T | Gastric restriction method and system for treatment of eating disorders |
US20080172072A1 (en) | 2007-01-11 | 2008-07-17 | Ellipse Technologies, Inc. | Internal sensors for use with gastric restriction devices |
US8083665B2 (en) | 2007-03-06 | 2011-12-27 | Ethicon Endo-Surgery, Inc. | Pressure sensors for gastric band and adjacent tissue |
US8920307B2 (en) | 2007-03-06 | 2014-12-30 | Ethicon Endo-Surgery, Inc. | Gastric band system with esophageal sensor |
EP2134303A1 (en) | 2007-03-29 | 2009-12-23 | Jaime Vargas | Intragastric implant devices |
US8226602B2 (en) | 2007-03-30 | 2012-07-24 | Reshape Medical, Inc. | Intragastric balloon system and therapeutic processes and products |
US20080255403A1 (en) | 2007-04-13 | 2008-10-16 | Ethicon Endo-Surgery, Inc. | Magnetic nanoparticle therapies |
US20080275294A1 (en) | 2007-05-01 | 2008-11-06 | Michael Gertner | Pericardial inserts |
US8317676B2 (en) | 2007-05-14 | 2012-11-27 | Ethicon Endo-Surgery, Inc. | Gastric band with contrasting supply tube |
US20080287976A1 (en) | 2007-05-14 | 2008-11-20 | Weaner Lauren S | Gastric band with engagement member |
US8485964B2 (en) | 2007-05-15 | 2013-07-16 | Ethicon Endo-Surgery, Inc. | Gastric band with supply tube check valve |
FR2921822A1 (en) | 2007-10-05 | 2009-04-10 | Dominique Branche | Gastric band for treating obesity, has inflatable element defining passage for esophagus at interior of loop, and flexible tab integrated with support, and radially withdrawn towards interior of passage, where color of band is light blue |
WO2009050709A2 (en) | 2007-10-15 | 2009-04-23 | Isaac Tavori | Apparatus and methods for corrective guidance of eating behavior after weight loss surgery |
FR2922097B1 (en) | 2007-10-16 | 2010-09-24 | Cie Euro Etude Rech Paroscopie | GASTRIC RING BI-BALLOON |
US8187163B2 (en) | 2007-12-10 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Methods for implanting a gastric restriction device |
US8100870B2 (en) | 2007-12-14 | 2012-01-24 | Ethicon Endo-Surgery, Inc. | Adjustable height gastric restriction devices and methods |
US20090157113A1 (en) | 2007-12-18 | 2009-06-18 | Ethicon Endo-Surgery, Inc. | Wearable elements for implantable restriction systems |
US20090171379A1 (en) | 2007-12-27 | 2009-07-02 | Ethicon Endo-Surgery, Inc. | Fluid logic for regulating restriction devices |
US8377079B2 (en) | 2007-12-27 | 2013-02-19 | Ethicon Endo-Surgery, Inc. | Constant force mechanisms for regulating restriction devices |
US8142452B2 (en) | 2007-12-27 | 2012-03-27 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
US20090187202A1 (en) | 2008-01-17 | 2009-07-23 | Ortiz Mark S | Optimizing the operation of a restriction system |
US8192350B2 (en) | 2008-01-28 | 2012-06-05 | Ethicon Endo-Surgery, Inc. | Methods and devices for measuring impedance in a gastric restriction system |
US8591395B2 (en) | 2008-01-28 | 2013-11-26 | Ethicon Endo-Surgery, Inc. | Gastric restriction device data handling devices and methods |
US8337389B2 (en) | 2008-01-28 | 2012-12-25 | Ethicon Endo-Surgery, Inc. | Methods and devices for diagnosing performance of a gastric restriction system |
US20090192541A1 (en) | 2008-01-28 | 2009-07-30 | Ethicon Endo-Surgery, Inc. | Methods and devices for predicting performance of a gastric restriction system |
US20090192534A1 (en) | 2008-01-29 | 2009-07-30 | Ethicon Endo-Surgery, Inc. | Sensor trigger |
CA2713814C (en) | 2008-01-30 | 2014-09-02 | Medical Components, Inc. | Gastric inflation band with integrated infusion catheter |
US7844342B2 (en) | 2008-02-07 | 2010-11-30 | Ethicon Endo-Surgery, Inc. | Powering implantable restriction systems using light |
US8114345B2 (en) | 2008-02-08 | 2012-02-14 | Ethicon Endo-Surgery, Inc. | System and method of sterilizing an implantable medical device |
US8591532B2 (en) | 2008-02-12 | 2013-11-26 | Ethicon Endo-Sugery, Inc. | Automatically adjusting band system |
US20090209995A1 (en) | 2008-02-14 | 2009-08-20 | Byrum Randal T | Implantable adjustable sphincter system |
US20090220176A1 (en) | 2008-02-15 | 2009-09-03 | Fusco Michael T | Self-sealing container |
US8233995B2 (en) | 2008-03-06 | 2012-07-31 | Ethicon Endo-Surgery, Inc. | System and method of aligning an implantable antenna |
US20090228063A1 (en) | 2008-03-06 | 2009-09-10 | Ethicon Endo-Surgery, Inc. | System and method of communicating with an implantable antenna |
JP2011518617A (en) | 2008-04-23 | 2011-06-30 | アラーガン、インコーポレイテッド | Remotely adjustable gastric banding system |
US20100305397A1 (en) | 2008-10-06 | 2010-12-02 | Allergan Medical Sarl | Hydraulic-mechanical gastric band |
EP2362762A1 (en) | 2008-10-06 | 2011-09-07 | Allergan Medical Sàrl | Mechanical gastric band with cushions |
US20100185049A1 (en) | 2008-10-22 | 2010-07-22 | Allergan, Inc. | Dome and screw valves for remotely adjustable gastric banding systems |
EP2373264A1 (en) | 2008-10-22 | 2011-10-12 | Allergan, Inc. | Electrically activated valve for implantable fluid handling system |
EP2191796A1 (en) | 2008-11-28 | 2010-06-02 | Debiotech S.A. | Artificial sphincter assembly |
US20100191265A1 (en) | 2009-01-29 | 2010-07-29 | Cavu Medical, Inc. | Assembly and method for automatically controlling pressure for a gastric band |
US20100191271A1 (en) | 2009-01-29 | 2010-07-29 | Lilip Lau | Assembly and method for automatically controlling pressure for a gastric band |
WO2010127248A2 (en) | 2009-05-01 | 2010-11-04 | Allergan, Inc. | Laparoscopic gastric band with active agents |
US20110201874A1 (en) | 2010-02-12 | 2011-08-18 | Allergan, Inc. | Remotely adjustable gastric banding system |
-
2006
- 2006-04-05 US US11/397,795 patent/US8251888B2/en not_active Expired - Fee Related
- 2006-04-07 EP EP06740773A patent/EP1871312A2/en not_active Withdrawn
- 2006-04-07 BR BRPI0608191-6A patent/BRPI0608191A2/en not_active IP Right Cessation
- 2006-04-07 AU AU2006236883A patent/AU2006236883B2/en not_active Ceased
- 2006-04-07 CA CA002604618A patent/CA2604618A1/en not_active Abandoned
- 2006-04-07 JP JP2008506550A patent/JP2008536561A/en active Pending
- 2006-04-07 WO PCT/US2006/013184 patent/WO2006113187A2/en active Application Filing
-
2010
- 2010-02-18 US US12/707,920 patent/US8623042B2/en not_active Expired - Fee Related
Patent Citations (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1174814A (en) * | 1915-09-17 | 1916-03-07 | Manville E J Machine Co | Automatic threader. |
US1999683A (en) * | 1933-12-01 | 1935-04-30 | Helge A Borresen | Hose clamp |
US2163048A (en) * | 1937-02-13 | 1939-06-20 | Mckee Brothers Corp | Band clamp |
US2339138A (en) * | 1942-09-18 | 1944-01-11 | Central Equipment Co | Clamp |
US2405667A (en) * | 1944-01-20 | 1946-08-13 | Ottesen Andrew | Receptacle cover |
US2438231A (en) * | 1946-01-18 | 1948-03-23 | Schultz | Closure for fountain pens and the like |
US2635907A (en) * | 1950-11-13 | 1953-04-21 | Brummer Mfg Corp | Seal for shafts |
US2936980A (en) * | 1954-10-01 | 1960-05-17 | Illinois Tool Works | Cable strap |
US2714469A (en) * | 1954-11-24 | 1955-08-02 | Emery Carpenter Container Comp | Locking ring construction |
US3189961A (en) * | 1963-09-17 | 1965-06-22 | Rotron Mfg Co | Hose clamp |
US3667081A (en) * | 1969-11-03 | 1972-06-06 | Bosch Gmbh Robert | Window-cleaning arrangement |
US3955834A (en) * | 1972-02-11 | 1976-05-11 | Aktiebolaget Svenska Flaktfabriken | Apparatus for connecting ducts with a self-sealing joint |
US4133315A (en) * | 1976-12-27 | 1979-01-09 | Berman Edward J | Method and apparatus for reducing obesity |
US4157713A (en) * | 1977-05-11 | 1979-06-12 | Clarey Michael T | Air-pressure splint |
US4271827A (en) * | 1979-09-13 | 1981-06-09 | Angelchik Jean P | Method for prevention of gastro esophageal reflux |
US4399809A (en) * | 1979-10-30 | 1983-08-23 | Baro Juan V | Artificial sphincter for use at stoma, or for the like purposes |
US4442153A (en) * | 1980-12-19 | 1984-04-10 | Siemens Aktiengesellschaft | Longitudinally divided cable sleeve of thermo-plastic synthetic material with a shape memory |
US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
US4582640A (en) * | 1982-03-08 | 1986-04-15 | Collagen Corporation | Injectable cross-linked collagen implant material |
US4492004A (en) * | 1982-12-03 | 1985-01-08 | Hans Oetiker | Earless clamp structure |
US4592355A (en) * | 1983-01-28 | 1986-06-03 | Eliahu Antebi | Process for tying live tissue and an instrument for performing the tying operation |
US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4601713A (en) * | 1985-06-11 | 1986-07-22 | Genus Catheter Technologies, Inc. | Variable diameter catheter |
US4592339A (en) * | 1985-06-12 | 1986-06-03 | Mentor Corporation | Gastric banding device |
US4671351A (en) * | 1985-07-17 | 1987-06-09 | Vertech Treatment Systems, Inc. | Fluid treatment apparatus and heat exchanger |
US4753086A (en) * | 1986-01-13 | 1988-06-28 | Schmidt Kenneth J | Costume jewelry circlet |
US5120313A (en) * | 1986-03-28 | 1992-06-09 | Nancy W. Elftman | Method for measuring blood pressure in an animal or human using a percutaneous access port |
US4803075A (en) * | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
US5091171A (en) * | 1986-12-23 | 1992-02-25 | Yu Ruey J | Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use |
US5091171B2 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
US5091171B1 (en) * | 1986-12-23 | 1995-09-26 | Ruey J Yu | Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use |
US4944659A (en) * | 1987-01-27 | 1990-07-31 | Kabivitrum Ab | Implantable piezoelectric pump system |
US4760837A (en) * | 1987-02-19 | 1988-08-02 | Inamed Development Company | Apparatus for verifying the position of needle tip within the injection reservoir of an implantable medical device |
US5084061A (en) * | 1987-09-25 | 1992-01-28 | Gau Fred C | Intragastric balloon with improved valve locating means |
US4925446A (en) * | 1988-07-06 | 1990-05-15 | Transpharm Group Inc. | Removable inflatable intragastrointestinal device for delivering beneficial agents |
US4944487A (en) * | 1989-05-08 | 1990-07-31 | Lee Company | Diaphragm valve |
US4994019A (en) * | 1989-07-28 | 1991-02-19 | Micro-Magnetics, Inc. | Magnetic occluding device |
US6013679A (en) * | 1989-08-01 | 2000-01-11 | Anika Research, Inc. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
US6013679C1 (en) * | 1989-08-01 | 2001-06-19 | Anika Res Inc | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
US5886042A (en) * | 1989-08-15 | 1999-03-23 | Tristrata Technology, Inc. | Amphoteric compostion and polymeric forms of alpha hydroxyacids, and their therapeutic use |
US5399351A (en) * | 1990-07-09 | 1995-03-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
US5226429A (en) * | 1991-06-20 | 1993-07-13 | Inamed Development Co. | Laparoscopic gastric band and method |
US5188609A (en) * | 1991-07-08 | 1993-02-23 | Bryman Medical Inc. | Swivel clip medical tube holder |
US5224494A (en) * | 1992-03-19 | 1993-07-06 | Enhorning Goran E | Vaginal pessary |
US5391156A (en) * | 1992-06-30 | 1995-02-21 | Ethicon, Inc. | Flexible encoscopic surgical port |
US5326349A (en) * | 1992-07-09 | 1994-07-05 | Baraff David R | Artificial larynx |
USRE36176E (en) * | 1993-02-18 | 1999-03-30 | Kuzmak; Lubomyr I. | Laparoscopic adjustable gastric banding device and method for implantation and removal thereof |
US5633001A (en) * | 1993-03-19 | 1997-05-27 | Medinvent | Composition and a method for tissue augmentation |
US5601604A (en) * | 1993-05-27 | 1997-02-11 | Inamed Development Co. | Universal gastric band |
US5944751A (en) * | 1993-09-17 | 1999-08-31 | Zertl Medical, Inc. | Vibratory heart valve |
US5531716A (en) * | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
US5658298A (en) * | 1993-11-09 | 1997-08-19 | Inamed Development Company | Laparoscopic tool |
US5653718A (en) * | 1994-05-16 | 1997-08-05 | Yoon; Inbae | Cannula anchoring system |
US5704893A (en) * | 1994-07-11 | 1998-01-06 | Dacomed Corportion | Vessel occlusive apparatus and method |
US5509888A (en) * | 1994-07-26 | 1996-04-23 | Conceptek Corporation | Controller valve device and method |
US5769877A (en) * | 1995-01-04 | 1998-06-23 | Plexus, Inc. | High value capacitive, replenishable power source |
US5904697A (en) * | 1995-02-24 | 1999-05-18 | Heartport, Inc. | Devices and methods for performing a vascular anastomosis |
US5535752A (en) * | 1995-02-27 | 1996-07-16 | Medtronic, Inc. | Implantable capacitive absolute pressure and temperature monitor system |
US5748200A (en) * | 1995-03-23 | 1998-05-05 | Fuji Photo Film Co., Ltd. | Image displaying apparatus |
US5607418A (en) * | 1995-08-22 | 1997-03-04 | Illinois Institute Of Technology | Implantable drug delivery apparatus |
US5928195A (en) * | 1996-01-31 | 1999-07-27 | Malamud; Daniel | Remote control drug delivery device |
US6048309A (en) * | 1996-03-04 | 2000-04-11 | Heartport, Inc. | Soft tissue retractor and delivery device therefor |
US5766232A (en) * | 1996-05-10 | 1998-06-16 | Medtronic, Inc. | Method and apparatus for altering the Q of an implantable medical device telemetry antenna |
US5944696A (en) * | 1996-06-03 | 1999-08-31 | Bayless; William Brian | Swivel clip medical tube holder |
US5785295A (en) * | 1996-08-27 | 1998-07-28 | Industrial Technology Research Institute | Thermally buckling control microvalve |
US5713911A (en) * | 1996-10-03 | 1998-02-03 | United States Surgical Corporation | Surgical clip |
US6024340A (en) * | 1996-12-04 | 2000-02-15 | Active Control Experts, Inc. | Valve assembly |
US5861014A (en) * | 1997-04-30 | 1999-01-19 | Medtronic, Inc. | Method and apparatus for sensing a stimulating gastrointestinal tract on-demand |
US6083249A (en) * | 1997-04-30 | 2000-07-04 | Medtronic, Inc. | Apparatus for sensing and stimulating gastrointestinal tract on-demand |
US5938669A (en) * | 1997-05-07 | 1999-08-17 | Klasamed S.A. | Adjustable gastric banding device for contracting a patient's stomach |
US5910149A (en) * | 1998-04-29 | 1999-06-08 | Kuzmak; Lubomyr I. | Non-slipping gastric band |
US6024704A (en) * | 1998-04-30 | 2000-02-15 | Medtronic, Inc | Implantable medical device for sensing absolute blood pressure and barometric pressure |
US6074341A (en) * | 1998-06-09 | 2000-06-13 | Timm Medical Technologies, Inc. | Vessel occlusive apparatus and method |
US6067991A (en) * | 1998-08-13 | 2000-05-30 | Forsell; Peter | Mechanical food intake restriction device |
US20030019498A1 (en) * | 1998-08-13 | 2003-01-30 | Obtech Medical Ag. | Non-injection port food intake restriction device |
US6676674B1 (en) * | 1999-03-17 | 2004-01-13 | Moshe Dudai | Gastric band |
US7160312B2 (en) * | 1999-06-25 | 2007-01-09 | Usgi Medical, Inc. | Implantable artificial partition and methods of use |
US7017583B2 (en) * | 1999-08-12 | 2006-03-28 | Peter Forsell | Food intake restriction with controlled wireless energy supply |
US20030066536A1 (en) * | 1999-08-12 | 2003-04-10 | Obtech Medical Ag | Controlled food intake restriction |
US20020072780A1 (en) * | 2000-09-26 | 2002-06-13 | Transneuronix, Inc. | Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity |
US20040044332A1 (en) * | 2000-11-03 | 2004-03-04 | Nikolaus Stergiopulos | Implantable medical device for delivering a liquid |
US20040059393A1 (en) * | 2001-01-05 | 2004-03-25 | Shai Policker | Regulation of eating habits |
US20020091395A1 (en) * | 2001-01-08 | 2002-07-11 | Shlomo Gabbay | System to inhibit and/or control expansion of anatomical features |
US20020098097A1 (en) * | 2001-01-22 | 2002-07-25 | Angad Singh | Magnetically-actuated micropump |
US20040147816A1 (en) * | 2001-04-18 | 2004-07-29 | Shai Policker | Analysis of eating habits |
US20040133219A1 (en) * | 2002-07-29 | 2004-07-08 | Peter Forsell | Multi-material constriction device for forming stoma opening |
US20050143766A1 (en) * | 2002-09-04 | 2005-06-30 | Endoart Sa | Telemetrically controlled band for regulating functioning of a body organ or duct, and methods of making, implantation and use |
US20050143765A1 (en) * | 2002-09-04 | 2005-06-30 | Endoart Sa | Telemetrically controlled band for regulating functioning of a body organ or duct, and methods of making, implantation and use |
US7037344B2 (en) * | 2002-11-01 | 2006-05-02 | Valentx, Inc. | Apparatus and methods for treatment of morbid obesity |
US20040148034A1 (en) * | 2002-11-01 | 2004-07-29 | Jonathan Kagan | Apparatus and methods for treatment of morbid obesity |
US20050131485A1 (en) * | 2003-02-03 | 2005-06-16 | Enteromedics, Inc. | High frequency vagal blockage therapy |
US20050038484A1 (en) * | 2003-02-03 | 2005-02-17 | Enteromedics, Inc. | Controlled vagal blockage therapy |
US20050055039A1 (en) * | 2003-07-28 | 2005-03-10 | Polymorfix, Inc. | Devices and methods for pyloric anchoring |
US20050119674A1 (en) * | 2003-10-23 | 2005-06-02 | Peter Gingras | Gastric constriction device |
US20090082793A1 (en) * | 2004-01-23 | 2009-03-26 | Allergan, Inc. | Releasably-securable one-piece adjustable gastric band |
US20060074473A1 (en) * | 2004-03-23 | 2006-04-06 | Michael Gertner | Methods and devices for combined gastric restriction and electrical stimulation |
US20060089571A1 (en) * | 2004-03-23 | 2006-04-27 | Michael Gertner | Obesity treatment systems |
US7390294B2 (en) * | 2004-05-28 | 2008-06-24 | Ethicon Endo-Surgery, Inc. | Piezo electrically driven bellows infuser for hydraulically controlling an adjustable gastric band |
US20060020298A1 (en) * | 2004-07-20 | 2006-01-26 | Camilleri Michael L | Systems and methods for curbing appetite |
US8057492B2 (en) * | 2008-02-12 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Automatically adjusting band system with MEMS pump |
US8034065B2 (en) * | 2008-02-26 | 2011-10-11 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
US20100010291A1 (en) * | 2008-07-14 | 2010-01-14 | Allergan, Inc. | Implantable pump system with calibration |
US7896787B2 (en) * | 2008-09-05 | 2011-03-01 | Michael Adam LaSala | Health and fitness device |
US20100100079A1 (en) * | 2008-10-21 | 2010-04-22 | General Electric Company | Implantable device system |
Cited By (198)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9668900B2 (en) | 2002-05-09 | 2017-06-06 | Reshape Medical, Inc. | Balloon system and methods for treating obesity |
US8845513B2 (en) | 2002-08-13 | 2014-09-30 | Apollo Endosurgery, Inc. | Remotely adjustable gastric banding device |
US8382780B2 (en) | 2002-08-28 | 2013-02-26 | Allergan, Inc. | Fatigue-resistant gastric banding device |
US8900117B2 (en) | 2004-01-23 | 2014-12-02 | Apollo Endosurgery, Inc. | Releasably-securable one-piece adjustable gastric band |
US8377081B2 (en) | 2004-03-08 | 2013-02-19 | Allergan, Inc. | Closure system for tubular organs |
US8236023B2 (en) | 2004-03-18 | 2012-08-07 | Allergan, Inc. | Apparatus and method for volume adjustment of intragastric balloons |
US7775215B2 (en) | 2005-02-24 | 2010-08-17 | Ethicon Endo-Surgery, Inc. | System and method for determining implanted device positioning and obtaining pressure data |
US7658196B2 (en) | 2005-02-24 | 2010-02-09 | Ethicon Endo-Surgery, Inc. | System and method for determining implanted device orientation |
US7927270B2 (en) | 2005-02-24 | 2011-04-19 | Ethicon Endo-Surgery, Inc. | External mechanical pressure sensor for gastric band pressure measurements |
US8016744B2 (en) | 2005-02-24 | 2011-09-13 | Ethicon Endo-Surgery, Inc. | External pressure-based gastric band adjustment system and method |
US8066629B2 (en) | 2005-02-24 | 2011-11-29 | Ethicon Endo-Surgery, Inc. | Apparatus for adjustment and sensing of gastric band pressure |
US8016745B2 (en) | 2005-02-24 | 2011-09-13 | Ethicon Endo-Surgery, Inc. | Monitoring of a food intake restriction device |
US7775966B2 (en) | 2005-02-24 | 2010-08-17 | Ethicon Endo-Surgery, Inc. | Non-invasive pressure measurement in a fluid adjustable restrictive device |
US8623042B2 (en) | 2005-04-13 | 2014-01-07 | Mitchell Roslin | Artificial gastric valve |
US9962276B2 (en) | 2005-10-31 | 2018-05-08 | Reshape Medical Llc | Intragastric space filler |
US8323180B2 (en) | 2006-01-04 | 2012-12-04 | Allergan, Inc. | Hydraulic gastric band with collapsible reservoir |
US8905915B2 (en) | 2006-01-04 | 2014-12-09 | Apollo Endosurgery, Inc. | Self-regulating gastric band with pressure data processing |
US8308630B2 (en) | 2006-01-04 | 2012-11-13 | Allergan, Inc. | Hydraulic gastric band with collapsible reservoir |
US8870742B2 (en) | 2006-04-06 | 2014-10-28 | Ethicon Endo-Surgery, Inc. | GUI for an implantable restriction device and a data logger |
US8152710B2 (en) | 2006-04-06 | 2012-04-10 | Ethicon Endo-Surgery, Inc. | Physiological parameter analysis for an implantable restriction device and a data logger |
US20070255336A1 (en) * | 2006-04-28 | 2007-11-01 | Medtronic, Inc. | Gastric constriction device with selectable electrode combinations |
US20070255335A1 (en) * | 2006-04-28 | 2007-11-01 | Medtronic, Inc. | Controller for gastric constriction device with selectable electrode configurations |
US9271857B2 (en) | 2006-10-20 | 2016-03-01 | Ellipse Technologies, Inc. | Adjustable implant and method of use |
US10039661B2 (en) | 2006-10-20 | 2018-08-07 | Nuvasive Specialized Orthopedics, Inc. | Adjustable implant and method of use |
US8246533B2 (en) | 2006-10-20 | 2012-08-21 | Ellipse Technologies, Inc. | Implant system with resonant-driven actuator |
US8715159B2 (en) | 2006-10-20 | 2014-05-06 | Ellipse Technologies, Inc. | Adjustable implant and method of use |
US7862502B2 (en) | 2006-10-20 | 2011-01-04 | Ellipse Technologies, Inc. | Method and apparatus for adjusting a gastrointestinal restriction device |
US8808163B2 (en) | 2006-10-20 | 2014-08-19 | Ellipse Technologies, Inc. | Adjustable implant and method of use |
US7981025B2 (en) | 2006-10-20 | 2011-07-19 | Ellipse Technologies, Inc. | Adjustable implant and method of use |
US9526650B2 (en) | 2006-10-20 | 2016-12-27 | Nuvasive Specialized Orthopedics, Inc. | Adjustable implant and method of use |
US8083665B2 (en) | 2007-03-06 | 2011-12-27 | Ethicon Endo-Surgery, Inc. | Pressure sensors for gastric band and adjacent tissue |
US8920307B2 (en) * | 2007-03-06 | 2014-12-30 | Ethicon Endo-Surgery, Inc. | Gastric band system with esophageal sensor |
US20100152532A1 (en) * | 2007-03-06 | 2010-06-17 | Marcotte Amy L | Gastric Band System with Esophageal Sensor |
US20080221598A1 (en) * | 2007-03-06 | 2008-09-11 | Dlugos Daniel F | Pressure Sensors for Gastric Band and Adjacent Tissue |
US8187163B2 (en) | 2007-12-10 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Methods for implanting a gastric restriction device |
US8100870B2 (en) | 2007-12-14 | 2012-01-24 | Ethicon Endo-Surgery, Inc. | Adjustable height gastric restriction devices and methods |
US8377079B2 (en) | 2007-12-27 | 2013-02-19 | Ethicon Endo-Surgery, Inc. | Constant force mechanisms for regulating restriction devices |
US8142452B2 (en) | 2007-12-27 | 2012-03-27 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
US8192350B2 (en) | 2008-01-28 | 2012-06-05 | Ethicon Endo-Surgery, Inc. | Methods and devices for measuring impedance in a gastric restriction system |
US8337389B2 (en) | 2008-01-28 | 2012-12-25 | Ethicon Endo-Surgery, Inc. | Methods and devices for diagnosing performance of a gastric restriction system |
US8591395B2 (en) | 2008-01-28 | 2013-11-26 | Ethicon Endo-Surgery, Inc. | Gastric restriction device data handling devices and methods |
EP3434230A1 (en) * | 2008-01-29 | 2019-01-30 | Kirk Promotion LTD. | A device for treating obesity |
US10653542B2 (en) | 2008-01-29 | 2020-05-19 | Peter Forsell | Device, system and method for treating obesity |
EP2240133A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | Methods and instruments for treating gerd and hiatal hernia |
US11666469B2 (en) | 2008-01-29 | 2023-06-06 | Peter Forsell | Method and instrument for treating obesity |
EP2240134A4 (en) * | 2008-01-29 | 2011-11-30 | Milux Holding Sa | Methods and instruments for treating obesity and gastroesophageal reflux disease |
JP7343636B2 (en) | 2008-01-29 | 2023-09-12 | インプランティカ・パテント・リミテッド | Device for treating GERD |
AU2009209519B2 (en) * | 2008-01-29 | 2015-05-07 | Implantica Patent Ltd. | A device, system and method for treating obesity |
US9277920B2 (en) | 2008-01-29 | 2016-03-08 | Peter Forsell | Apparatus for treating GERD comprising a stimulation device |
US20120022561A1 (en) * | 2008-01-29 | 2012-01-26 | Milux Holding S.A. | apparatus for treating gerd |
EP2240138A4 (en) * | 2008-01-29 | 2012-02-08 | Milux Holding Sa | Apparatus for treating obesity |
US8992629B2 (en) | 2008-01-29 | 2015-03-31 | Peter Forsell | Methods and instruments for treating GERD and hiatal hernia |
EP2240136A4 (en) * | 2008-01-29 | 2012-03-07 | Milux Holding Sa | Apparatus for treating reflux disease (gerd) and obesity |
EP2240133A4 (en) * | 2008-01-29 | 2015-03-25 | Kirk Promotion Ltd | Methods and instruments for treating gerd and hiatal hernia |
EP2240134A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | Methods and instruments for treating obesity and gastroesophageal reflux disease |
EP2240137A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | Apparatus and method for treating obesity |
EP2240130A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | A device for treating obesity |
US20110172693A1 (en) * | 2008-01-29 | 2011-07-14 | Peter Forsell | Apparatus and method for treating obesity |
US11389314B2 (en) | 2008-01-29 | 2022-07-19 | Peter Forsell | Method and instrument for treating obesity |
EP2240128A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | A method and instrument for treating obesity |
EP2240136A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | Apparatus for treating reflux disease (gerd) and obesity |
US9687335B2 (en) | 2008-01-29 | 2017-06-27 | Milux Holding Sa | Method and instruments for treating GERD |
US9877859B2 (en) | 2008-01-29 | 2018-01-30 | Peter Forsell | Methods and instruments for treating obesity and gastroesophageal reflux disease |
JP2022069501A (en) * | 2008-01-29 | 2022-05-11 | インプランティカ・パテント・リミテッド | Device for curing gerd |
EP2240131A4 (en) * | 2008-01-29 | 2012-09-05 | Milux Holding Sa | A device, system and method for treating obesity |
EP2240130A4 (en) * | 2008-01-29 | 2012-09-05 | Milux Holding Sa | A device for treating obesity |
EP2240128A4 (en) * | 2008-01-29 | 2012-09-05 | Milux Holding Sa | A method and instrument for treating obesity |
EP2240137A4 (en) * | 2008-01-29 | 2012-09-05 | Milux Holding Sa | Apparatus and method for treating obesity |
JP7036790B2 (en) | 2008-01-29 | 2022-03-15 | インプランティカ・パテント・リミテッド | A device for treating GERD |
EP2249753B1 (en) * | 2008-01-29 | 2022-03-09 | Implantica Patent Ltd. | Apparatus for treating obesity |
EP3957284A1 (en) * | 2008-01-29 | 2022-02-23 | Implantica Patent Ltd | Apparatus for treating obesity |
AU2020200750B2 (en) * | 2008-01-29 | 2021-11-25 | Implantica Patent Ltd | A Device, System and Method for Treating Obesity |
EP2249752A4 (en) * | 2008-01-29 | 2012-10-31 | Milux Holding Sa | Apparatus for treating obesity |
EP2240138A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | Apparatus for treating obesity |
EP2240131A1 (en) * | 2008-01-29 | 2010-10-20 | Milux Holding SA | A device, system and method for treating obesity |
US20110009894A1 (en) * | 2008-01-29 | 2011-01-13 | Peter Forsell | Apparatus for treating reflux disease (gerd) and obesity |
EP3895670A1 (en) * | 2008-01-29 | 2021-10-20 | Implantica Patent Ltd. | Apparatus and method for treating obesity |
EP2249752A1 (en) * | 2008-01-29 | 2010-11-17 | Milux Holding SA | Apparatus for treating obesity |
US20110009897A1 (en) * | 2008-01-29 | 2011-01-13 | Peter Forsell | Apparatus for treating obesity and reflux disease |
US20100331617A1 (en) * | 2008-01-29 | 2010-12-30 | Peter Forsell | Device, system and method for treating obesity |
US20100331614A1 (en) * | 2008-01-29 | 2010-12-30 | Peter Forsell | Methods and instruments for treating obesity and gastroesophageal reflux disease |
US20100331615A1 (en) * | 2008-01-29 | 2010-12-30 | Peter Forsell | Method and instruments for treating gerd |
US20100324360A1 (en) * | 2008-01-29 | 2010-12-23 | Peter Forsell | Apparatus for treating gerd |
US11020258B2 (en) | 2008-01-29 | 2021-06-01 | Peter Forsell | Apparatus for treating GERD |
US10045869B2 (en) | 2008-01-29 | 2018-08-14 | Peter Forsell | Apparatus for treating obesity and reflux disease |
US20100312049A1 (en) * | 2008-01-29 | 2010-12-09 | Peter Forsell | Apparatus for treating obesity |
EP3417837A1 (en) * | 2008-01-29 | 2018-12-26 | Kirk Promotion LTD. | Instruments for treating gerd and hiatal hernia |
US10945870B2 (en) | 2008-01-29 | 2021-03-16 | Peter Forsell | Apparatus for treating obesity |
US10857018B2 (en) | 2008-01-29 | 2020-12-08 | Peter Forsell | Apparatus for treating obesity |
US10653543B2 (en) * | 2008-01-29 | 2020-05-19 | Peter Forsell | Apparatus for treating GERD |
US11510770B2 (en) | 2008-01-29 | 2022-11-29 | Peter Forsell | Apparatus for treating reflux disease (GERD) and obesity |
JP2020044442A (en) * | 2008-01-29 | 2020-03-26 | インプランティカ・パテント・リミテッド | Apparatus for treating gerd |
US9060771B2 (en) | 2008-01-29 | 2015-06-23 | Peter Forsell | Method and instrument for treating obesity |
US10548752B2 (en) * | 2008-01-29 | 2020-02-04 | Peter Forsell | Apparatus and method for treating obesity |
US8567409B2 (en) | 2008-01-29 | 2013-10-29 | Milux Holding Sa | Method and instruments for treating GERD |
US8636809B2 (en) | 2008-01-29 | 2014-01-28 | Milux Holding Sa | Device for treating obesity |
US20100324362A1 (en) * | 2008-01-29 | 2010-12-23 | Peter Forsell | Apparatus for treating obesity and reflux disease |
US20100312356A1 (en) * | 2008-01-29 | 2010-12-09 | Peter Forsell | Methods and instruments for treating gerd and haital hernia |
AU2017254825B2 (en) * | 2008-01-29 | 2019-10-31 | Implantica Patent Ltd | A Device, System and Method for Treating Obesity |
US20100324361A1 (en) * | 2008-01-29 | 2010-12-23 | Peter Forsell | Apparatus for treating obesity |
US7844342B2 (en) | 2008-02-07 | 2010-11-30 | Ethicon Endo-Surgery, Inc. | Powering implantable restriction systems using light |
US8221439B2 (en) | 2008-02-07 | 2012-07-17 | Ethicon Endo-Surgery, Inc. | Powering implantable restriction systems using kinetic motion |
US8114345B2 (en) | 2008-02-08 | 2012-02-14 | Ethicon Endo-Surgery, Inc. | System and method of sterilizing an implantable medical device |
US8591532B2 (en) | 2008-02-12 | 2013-11-26 | Ethicon Endo-Sugery, Inc. | Automatically adjusting band system |
US8057492B2 (en) | 2008-02-12 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Automatically adjusting band system with MEMS pump |
US8034065B2 (en) | 2008-02-26 | 2011-10-11 | Ethicon Endo-Surgery, Inc. | Controlling pressure in adjustable restriction devices |
US8187162B2 (en) | 2008-03-06 | 2012-05-29 | Ethicon Endo-Surgery, Inc. | Reorientation port |
US8233995B2 (en) | 2008-03-06 | 2012-07-31 | Ethicon Endo-Surgery, Inc. | System and method of aligning an implantable antenna |
US8409221B2 (en) | 2008-04-17 | 2013-04-02 | Allergan, Inc. | Implantable access port device having a safety cap |
US8398654B2 (en) | 2008-04-17 | 2013-03-19 | Allergan, Inc. | Implantable access port device and attachment system |
US9023063B2 (en) | 2008-04-17 | 2015-05-05 | Apollo Endosurgery, Inc. | Implantable access port device having a safety cap |
US9023062B2 (en) | 2008-04-17 | 2015-05-05 | Apollo Endosurgery, Inc. | Implantable access port device and attachment system |
US20110137428A1 (en) * | 2008-08-13 | 2011-06-09 | Gad Terliuc | Liner for tubular body portion and apparatus and methods for application thereof |
US8828090B2 (en) | 2008-08-13 | 2014-09-09 | Binerix Medical Ltd. | Liner for tubular body portion and apparatus and methods for application thereof |
US8317677B2 (en) | 2008-10-06 | 2012-11-27 | Allergan, Inc. | Mechanical gastric band with cushions |
EP2349131A4 (en) * | 2008-10-10 | 2012-10-31 | Milux Holding Sa | Apparatus for treating obesity |
EP2349131A1 (en) * | 2008-10-10 | 2011-08-03 | Milux Holding SA | Apparatus for treating obesity |
CN105361986A (en) * | 2008-10-10 | 2016-03-02 | 米卢克斯控股股份有限公司 | An apparatus for treating gerd |
US9375213B2 (en) | 2008-10-10 | 2016-06-28 | Peter Forsell | Methods and instruments for treating obesity |
US8900118B2 (en) | 2008-10-22 | 2014-12-02 | Apollo Endosurgery, Inc. | Dome and screw valves for remotely adjustable gastric banding systems |
EP2405869A4 (en) * | 2009-01-29 | 2012-10-31 | Milux Holding Sa | Obesity treatment |
EP2405869A1 (en) * | 2009-01-29 | 2012-01-18 | Milux Holding SA | Obesity treatment |
US20100280304A1 (en) * | 2009-05-04 | 2010-11-04 | Tyco Healthcare Group Lp | Magnetic Gastric Reduction Device |
US8591396B2 (en) * | 2009-05-04 | 2013-11-26 | Covidien Lp | Magnetic gastric reduction device |
US11944763B2 (en) | 2009-06-18 | 2024-04-02 | Cm Technologies, Inc. | Device for collecting material from a body cavity |
US10953200B2 (en) | 2009-06-18 | 2021-03-23 | Department Of Biotechnology | Device for collecting material from a body cavity |
US8840594B2 (en) | 2009-06-18 | 2014-09-23 | Department Of Biotechnology, Ministry Of Science And Technology, Government Of India | Device for collecting fecal discharge in incontinent patients |
US9987470B2 (en) | 2009-07-23 | 2018-06-05 | ReShape Medical, LLC | Deflation and removal of implantable medical devices |
EP2456487A4 (en) * | 2009-07-23 | 2017-05-17 | ReShape Medical, Inc. | Inflation and deflation mechanisms for inflatable medical devices |
US10024752B2 (en) | 2009-08-18 | 2018-07-17 | Innovative Pressure Testing, Llc | System and method for detecting leaks |
US10031042B2 (en) | 2009-08-18 | 2018-07-24 | Innovative Pressure Testing, Llc | System and method for detecting leaks |
US8708979B2 (en) | 2009-08-26 | 2014-04-29 | Apollo Endosurgery, Inc. | Implantable coupling device |
US8715158B2 (en) | 2009-08-26 | 2014-05-06 | Apollo Endosurgery, Inc. | Implantable bottom exit port |
US8506532B2 (en) | 2009-08-26 | 2013-08-13 | Allergan, Inc. | System including access port and applicator tool |
WO2011081782A1 (en) * | 2009-12-14 | 2011-07-07 | Ethicon Endo-Surgery,Inc. | Gastric band system with esophageal sensor |
WO2011097451A1 (en) | 2010-02-05 | 2011-08-11 | Allergan, Inc. | Implantable subcutaneous access port |
US8882728B2 (en) | 2010-02-10 | 2014-11-11 | Apollo Endosurgery, Inc. | Implantable injection port |
US8678993B2 (en) | 2010-02-12 | 2014-03-25 | Apollo Endosurgery, Inc. | Remotely adjustable gastric banding system |
US8758221B2 (en) | 2010-02-24 | 2014-06-24 | Apollo Endosurgery, Inc. | Source reservoir with potential energy for remotely adjustable gastric banding system |
US8608642B2 (en) | 2010-02-25 | 2013-12-17 | Ethicon Endo-Surgery, Inc. | Methods and devices for treating morbid obesity using hydrogel |
WO2011106157A1 (en) | 2010-02-25 | 2011-09-01 | Ethicon Endo-Surgery, Inc. | Devices for treating morbid obesity using hydrogel |
US8764624B2 (en) | 2010-02-25 | 2014-07-01 | Apollo Endosurgery, Inc. | Inductively powered remotely adjustable gastric banding system |
US8840541B2 (en) | 2010-02-25 | 2014-09-23 | Apollo Endosurgery, Inc. | Pressure sensing gastric banding system |
US10117766B2 (en) | 2010-04-06 | 2018-11-06 | Reshape Medical Llc | Inflation devices for intragastric devices with improved attachment and detachment and associated systems and methods |
US9265422B2 (en) | 2010-04-27 | 2016-02-23 | Apollo Endosurgery, Inc. | System and method for determining an adjustment to a gastric band based on satiety state data and weight loss data |
US8939888B2 (en) | 2010-04-28 | 2015-01-27 | Apollo Endosurgery, Inc. | Method and system for determining the pressure of a fluid in a syringe, an access port, a catheter, and a gastric band |
US9295573B2 (en) | 2010-04-29 | 2016-03-29 | Apollo Endosurgery, Inc. | Self-adjusting gastric band having various compliant components and/or a satiety booster |
US9044298B2 (en) | 2010-04-29 | 2015-06-02 | Apollo Endosurgery, Inc. | Self-adjusting gastric band |
WO2011137001A1 (en) | 2010-04-29 | 2011-11-03 | Allergan, Inc. | Self-adjusting gastric band |
US9028394B2 (en) | 2010-04-29 | 2015-05-12 | Apollo Endosurgery, Inc. | Self-adjusting mechanical gastric band |
WO2011137032A1 (en) | 2010-04-29 | 2011-11-03 | Allergan, Inc. | Self-adjusting mechanical gastric band |
WO2011139505A1 (en) | 2010-04-29 | 2011-11-10 | Allergan, Inc. | Self-adjusting gastric band having various compliant components |
US8992415B2 (en) | 2010-04-30 | 2015-03-31 | Apollo Endosurgery, Inc. | Implantable device to protect tubing from puncture |
US9241819B2 (en) | 2010-04-30 | 2016-01-26 | Apollo Endosurgery, Inc. | Implantable device to protect tubing from puncture |
US9192501B2 (en) | 2010-04-30 | 2015-11-24 | Apollo Endosurgery, Inc. | Remotely powered remotely adjustable gastric band system |
US9125718B2 (en) | 2010-04-30 | 2015-09-08 | Apollo Endosurgery, Inc. | Electronically enhanced access port for a fluid filled implant |
US9226840B2 (en) | 2010-06-03 | 2016-01-05 | Apollo Endosurgery, Inc. | Magnetically coupled implantable pump system and method |
US8517915B2 (en) | 2010-06-10 | 2013-08-27 | Allergan, Inc. | Remotely adjustable gastric banding system |
US8905916B2 (en) | 2010-08-16 | 2014-12-09 | Apollo Endosurgery, Inc. | Implantable access port system |
US9211207B2 (en) | 2010-08-18 | 2015-12-15 | Apollo Endosurgery, Inc. | Power regulated implant |
US8698373B2 (en) | 2010-08-18 | 2014-04-15 | Apollo Endosurgery, Inc. | Pare piezo power with energy recovery |
US9050165B2 (en) | 2010-09-07 | 2015-06-09 | Apollo Endosurgery, Inc. | Remotely adjustable gastric banding system |
US8882655B2 (en) | 2010-09-14 | 2014-11-11 | Apollo Endosurgery, Inc. | Implantable access port system |
US8961393B2 (en) | 2010-11-15 | 2015-02-24 | Apollo Endosurgery, Inc. | Gastric band devices and drive systems |
CN103429197A (en) * | 2010-12-29 | 2013-12-04 | 伊西康内外科公司 | Obesity therapy and heart rate variability |
US8696616B2 (en) | 2010-12-29 | 2014-04-15 | Ethicon Endo-Surgery, Inc. | Obesity therapy and heart rate variability |
WO2012091929A1 (en) * | 2010-12-29 | 2012-07-05 | Ethicon Endo-Surgery, Inc. | Obesity therapy and heart rate variability |
WO2012110623A1 (en) | 2011-02-17 | 2012-08-23 | Allergan Medical Sàrl | Hydraulic gastric band with reversible self-opening mechanism |
WO2012125694A2 (en) | 2011-03-16 | 2012-09-20 | Allergan, Inc. | Self-adjusting gastric band |
WO2012125698A1 (en) | 2011-03-16 | 2012-09-20 | Allergan, Inc. | Self-adjusting gastric band having various compliant components and/or satiety booster |
WO2012125700A2 (en) | 2011-03-16 | 2012-09-20 | Allergan, Inc. | Self-adjusting gastric band |
WO2012142214A1 (en) | 2011-04-13 | 2012-10-18 | Allergan, Inc. | Syringe-based leak detection system |
US8725435B2 (en) | 2011-04-13 | 2014-05-13 | Apollo Endosurgery, Inc. | Syringe-based leak detection system |
US8821373B2 (en) | 2011-05-10 | 2014-09-02 | Apollo Endosurgery, Inc. | Directionless (orientation independent) needle injection port |
WO2012154819A2 (en) | 2011-05-10 | 2012-11-15 | Allergan, Inc. | Directionless (orientation independent) needle injection port |
US8801597B2 (en) | 2011-08-25 | 2014-08-12 | Apollo Endosurgery, Inc. | Implantable access port with mesh attachment rivets |
WO2013028760A2 (en) | 2011-08-25 | 2013-02-28 | Allergan, Inc. | Implantable access port with mesh attachment rivets |
WO2013059419A2 (en) | 2011-10-20 | 2013-04-25 | Allergan, Inc. | Implantable injection port |
US9199069B2 (en) | 2011-10-20 | 2015-12-01 | Apollo Endosurgery, Inc. | Implantable injection port |
US8858421B2 (en) | 2011-11-15 | 2014-10-14 | Apollo Endosurgery, Inc. | Interior needle stick guard stems for tubes |
WO2013074342A1 (en) | 2011-11-15 | 2013-05-23 | Allergan, Inc. | Interior needle stick guard stems for tubes |
US9089395B2 (en) | 2011-11-16 | 2015-07-28 | Appolo Endosurgery, Inc. | Pre-loaded septum for use with an access port |
WO2013074343A1 (en) | 2011-11-16 | 2013-05-23 | Allergan, Inc. | Pre-loaded septum for use with an access port |
WO2013086136A1 (en) | 2011-12-07 | 2013-06-13 | Allergan, Inc. | Tube connector with a guiding tip |
US8876694B2 (en) * | 2011-12-07 | 2014-11-04 | Apollo Endosurgery, Inc. | Tube connector with a guiding tip |
US20130150664A1 (en) * | 2011-12-07 | 2013-06-13 | Allergan, Inc. | Tube connector with a guiding tip |
US8961394B2 (en) | 2011-12-20 | 2015-02-24 | Apollo Endosurgery, Inc. | Self-sealing fluid joint for use with a gastric band |
WO2013112442A1 (en) | 2012-01-23 | 2013-08-01 | Allergan, Inc. | Gastric bands for reducing obstructions |
US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
US9955914B2 (en) | 2013-03-13 | 2018-05-01 | Ethicon Llc | Meal detection devices and methods |
US10791988B2 (en) | 2013-03-13 | 2020-10-06 | Ethicon Llc | Meal detection devices and methods |
US9168000B2 (en) | 2013-03-13 | 2015-10-27 | Ethicon Endo-Surgery, Inc. | Meal detection devices and methods |
CN105393100A (en) * | 2013-05-21 | 2016-03-09 | 优罗曼姆斯公司 | Method and device for detecting a slow leak in an implantable hydraulic occlusion system |
US10301930B2 (en) | 2013-10-17 | 2019-05-28 | Innovative Pressure Testing, Llc | System and method for a benchmark pressure test |
US10161243B2 (en) | 2013-10-17 | 2018-12-25 | Innovative Pressure Testing, Llc | System and method for a benchmark pressure test |
EP3058327A4 (en) * | 2013-10-17 | 2017-05-31 | Innovative Pressure Testing LLC | System and method for a benchmark pressure test |
Also Published As
Publication number | Publication date |
---|---|
US20100274274A1 (en) | 2010-10-28 |
BRPI0608191A2 (en) | 2010-01-19 |
US8251888B2 (en) | 2012-08-28 |
EP1871312A2 (en) | 2008-01-02 |
WO2006113187A3 (en) | 2007-10-04 |
WO2006113187A2 (en) | 2006-10-26 |
CA2604618A1 (en) | 2006-10-26 |
AU2006236883B2 (en) | 2011-06-30 |
AU2006236883A1 (en) | 2006-10-26 |
US8623042B2 (en) | 2014-01-07 |
JP2008536561A (en) | 2008-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8251888B2 (en) | Artificial gastric valve | |
US11642234B2 (en) | Bariatric device and method | |
US8636751B2 (en) | Methods and devices for the rerouting of chyme to induce intestinal brake | |
US7037344B2 (en) | Apparatus and methods for treatment of morbid obesity | |
JP4943841B2 (en) | Gastrointestinal methods and devices for use in treating disorders | |
US20050245957A1 (en) | Biasing stretch receptors in stomach wall to treat obesity | |
US20110213448A1 (en) | Apparatus and methods for minimally invasive obesity treatment | |
Khanna | Endoluminal Bariatric Surgery: Emerging Trends and Techniques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: ALLERGAN MEDICAL SA, SWITZERLAND Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ROSLIN, MITCHELL;SHILOH, JOSEPH;REEL/FRAME:022075/0980;SIGNING DATES FROM 20081222 TO 20081223 Owner name: ALLERGAN MEDICAL SA, SWITZERLAND Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ROSLIN, MITCHELL;SHILOH, JOSEPH;SIGNING DATES FROM 20081222 TO 20081223;REEL/FRAME:022075/0980 |
|
AS | Assignment |
Owner name: ROSLIN, MITCHELL STEVEN, NEW YORK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ALLERGAN, INC.;REEL/FRAME:028559/0935 Effective date: 20120716 Owner name: SHILOH, JOSEPH, ISRAEL Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ALLERGAN, INC.;REEL/FRAME:028559/0935 Effective date: 20120716 |
|
REMI | Maintenance fee reminder mailed | ||
LAPS | Lapse for failure to pay maintenance fees | ||
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
|
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 20160828 |