US20070062825A1 - Multi-chamber container - Google Patents
Multi-chamber container Download PDFInfo
- Publication number
- US20070062825A1 US20070062825A1 US11/516,719 US51671906A US2007062825A1 US 20070062825 A1 US20070062825 A1 US 20070062825A1 US 51671906 A US51671906 A US 51671906A US 2007062825 A1 US2007062825 A1 US 2007062825A1
- Authority
- US
- United States
- Prior art keywords
- layer
- film
- melt
- chamber
- chamber container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229920000098 polyolefin Polymers 0.000 claims abstract description 47
- 229920001684 low density polyethylene Polymers 0.000 claims abstract description 43
- 239000004702 low-density polyethylene Substances 0.000 claims abstract description 43
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 39
- 238000005192 partition Methods 0.000 claims abstract description 25
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims abstract description 23
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims abstract description 23
- 239000004711 α-olefin Substances 0.000 claims abstract description 23
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims abstract description 20
- 239000010410 layer Substances 0.000 claims description 125
- 239000000203 mixture Substances 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 15
- 229910052751 metal Inorganic materials 0.000 claims description 10
- 239000002184 metal Substances 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000011888 foil Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 6
- 238000000638 solvent extraction Methods 0.000 claims description 6
- 229920000728 polyester Polymers 0.000 claims description 5
- 239000002356 single layer Substances 0.000 claims description 2
- 239000010408 film Substances 0.000 claims 6
- 239000010409 thin film Substances 0.000 claims 1
- -1 polypropylene Polymers 0.000 description 26
- 239000004743 Polypropylene Substances 0.000 description 20
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 18
- 229920000573 polyethylene Polymers 0.000 description 16
- 229920001155 polypropylene Polymers 0.000 description 15
- 229920000642 polymer Polymers 0.000 description 14
- 239000004698 Polyethylene Substances 0.000 description 13
- 238000000034 method Methods 0.000 description 13
- 229920005989 resin Polymers 0.000 description 12
- 239000011347 resin Substances 0.000 description 12
- 229910052782 aluminium Inorganic materials 0.000 description 7
- 239000005977 Ethylene Substances 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 6
- 229920001179 medium density polyethylene Polymers 0.000 description 6
- 239000004701 medium-density polyethylene Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 229920003355 Novatec® Polymers 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000004388 gamma ray sterilization Methods 0.000 description 4
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 description 4
- 239000005020 polyethylene terephthalate Substances 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 239000002985 plastic film Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 0 [1*]C1C(CC)CC(CC)C1[2*] Chemical compound [1*]C1C(CC)CC(CC)C1[2*] 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000004840 adhesive resin Substances 0.000 description 2
- 229920006223 adhesive resin Polymers 0.000 description 2
- 125000001118 alkylidene group Chemical group 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052681 coesite Inorganic materials 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229910052906 cristobalite Inorganic materials 0.000 description 2
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical compound C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 2
- 150000002430 hydrocarbons Chemical group 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N methylene hexane Natural products CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 2
- 229920006255 plastic film Polymers 0.000 description 2
- 229920006267 polyester film Polymers 0.000 description 2
- 229920002959 polymer blend Polymers 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229910052682 stishovite Inorganic materials 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 229920005992 thermoplastic resin Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- 229910052905 tridymite Inorganic materials 0.000 description 2
- OJOWICOBYCXEKR-APPZFPTMSA-N (1S,4R)-5-ethylidenebicyclo[2.2.1]hept-2-ene Chemical compound CC=C1C[C@@H]2C[C@@H]1C=C2 OJOWICOBYCXEKR-APPZFPTMSA-N 0.000 description 1
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 1
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 1
- KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical compound CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 1
- HECLRDQVFMWTQS-RGOKHQFPSA-N 1755-01-7 Chemical compound C1[C@H]2[C@@H]3CC=C[C@@H]3[C@@H]1C=C2 HECLRDQVFMWTQS-RGOKHQFPSA-N 0.000 description 1
- YRIYXMAKROEVBQ-UHFFFAOYSA-N 5,5-dimethylbicyclo[2.2.1]hept-2-ene Chemical compound C1C2C(C)(C)CC1C=C2 YRIYXMAKROEVBQ-UHFFFAOYSA-N 0.000 description 1
- YSWATWCBYRBYBO-UHFFFAOYSA-N 5-butylbicyclo[2.2.1]hept-2-ene Chemical compound C1C2C(CCCC)CC1C=C2 YSWATWCBYRBYBO-UHFFFAOYSA-N 0.000 description 1
- QHJIJNGGGLNBNJ-UHFFFAOYSA-N 5-ethylbicyclo[2.2.1]hept-2-ene Chemical compound C1C2C(CC)CC1C=C2 QHJIJNGGGLNBNJ-UHFFFAOYSA-N 0.000 description 1
- PCBPVYHMZBWMAZ-UHFFFAOYSA-N 5-methylbicyclo[2.2.1]hept-2-ene Chemical compound C1C2C(C)CC1C=C2 PCBPVYHMZBWMAZ-UHFFFAOYSA-N 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000009820 dry lamination Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229920001038 ethylene copolymer Polymers 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000007765 extrusion coating Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229920000092 linear low density polyethylene Polymers 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- XBFJAVXCNXDMBH-GEDKWGBFSA-N molport-035-785-283 Chemical group C1[C@@H](C23)C=C[C@H]1C3[C@@H]1C[C@H]2CC1 XBFJAVXCNXDMBH-GEDKWGBFSA-N 0.000 description 1
- JFNLZVQOOSMTJK-KNVOCYPGSA-N norbornene Chemical group C1[C@@H]2CC[C@H]1C=C2 JFNLZVQOOSMTJK-KNVOCYPGSA-N 0.000 description 1
- 229920006284 nylon film Polymers 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical compound CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 1
- 229920005629 polypropylene homopolymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/04—Partitions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- B32B15/085—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
- B32B27/325—Layered products comprising a layer of synthetic resin comprising polyolefins comprising polycycloolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
- B32B7/04—Interconnection of layers
- B32B7/06—Interconnection of layers permitting easy separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/14—Linings or internal coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3261—Flexible containers having several compartments
- B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2024—Separating means having peelable seals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/10—Coating on the layer surface on synthetic resin layer or on natural or synthetic rubber layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/20—Inorganic coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2255/00—Coating on the layer surface
- B32B2255/20—Inorganic coating
- B32B2255/205—Metallic coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/50—Properties of the layers or laminate having particular mechanical properties
- B32B2307/546—Flexural strength; Flexion stiffness
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/748—Releasability
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/75—Printability
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2435/00—Closures, end caps, stoppers
- B32B2435/02—Closures, end caps, stoppers for containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/40—Closed containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/40—Closed containers
- B32B2439/62—Boxes, cartons, cases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
Definitions
- This invention relates to a multi-chamber container having a plurality of chambers separated by a partition wall having a peelable seal layer (so-called easily peelable seal layer) and, particularly, to a multi-layered container having a plurality of chambers for medical use. More specifically, the invention relates to a multi-chamber container which enables the contents contained in a plurality of chambers to be mixed together by causing the plurality of chambers to communicate with each other upon peeling off of the partition wall having an easily peelable seal layer.
- a multi-chamber container having a plurality of small chambers for separately containing liquid agents, powder agents or solid agents has heretofore been formed by using a flexible plastic film.
- One chamber of a plurality of chambers is partitioned from another adjacent chamber by a partitioning wall that allows communication.
- the partitioning wall is such that the inner surfaces of the film forming the small chambers are directly melt-adhered together, or are melt-adhered together via an insert film held between the inner surfaces.
- the partitioning wall easily peels off when an external pressure is applied to the surface of the chambers containing the contents; i.e., interiors of the plurality of chambers communicate to allow the contents contained therein to be mixed together.
- the plastic film which includes sheet for forming plural chambers
- a two-layer film including an inner layer of a mixed resin of a straight-chain low-density polyethylene (LLDPE) and a polypropylene (PP) and an outer layer of the straight-chain low-density polyethylene (LLDPE)
- a three-layer film including an inner layer of the straight-chain low-density polyethylene (LLDPE) and the polypropylene (PP), an intermediate layer of a mixed resin of the straight-chain low-density polyethylene (LLDPE) and an ethylene/ ⁇ -olefin elastomer, and an outer layer of the straight-chain low-density polyethylene (LLDPE)
- the inner layers of the mixed resin of the straight-chain low-density polyethylene (LLDPE) and the polypropylene (PP) are sealed at a melt-adhesion temperature of about 110 to 130° C. to form an easily peelable seal layer, and are further sealed at a melt-adhesion temperature of about 170 to 200° C. to form a strongly melt-adhered layer.
- LLDPE straight-chain low-density polyethylene
- PP polypropylene
- the plastic film for forming plural chambers there have been used an aluminum foil laminate (three-layer film of polyester/aluminum foil/polyethylene), a laminated film including a silica-deposited layer (PE/SiO 2 /PET/SiO 2 /PE) and a polyethylene tubular film (U.S. Pat. No. 5,865,309, U.S. Pat. No. 5,706,937, JP-A-2003-104391).
- the multi-chamber container is formed of a chamber of the aluminum foil laminate overlaid on the laminated film including the silica-deposited layer, and a chamber of the polyethylene tubular film.
- the plurality of such chambers are melt-adhered together via a film forming a weakly melt-adhered portion of a polymer blend of a polyethylene and a polypropylene held between the inner surfaces of the polyethylene.
- a resin having small melt-adhering strength to the polyethylene which is the material forming the innermost layer for instance, a blend of a polyethylene and a resin with no compatibility thereto, is conventionally used.
- the present inventors have already proposed a multi-layered multi-chamber container for medical use which is formed by a multi-layered film including an innermost layer of a cyclic polyolefin or a polymer blend containing the cyclic polyolefin and a second layer of a linear polyolefin adjacent to the above layer (US 2006/0035044).
- the multi-layered multi-chamber container can be subjected to ⁇ -ray sterilization, decreases the low-molecular components and adhesive components that are eluted out from the multi-layered container to eliminate the above-noted problems.
- the present invention provides a seal layer (easily peelable seal layer) used for a multi-chamber container of which at least one chamber chiefly uses a layer of a cyclic polyolefin as an innermost layer, the seal layer being strongly melt-adhered to the innermost layer of the cyclic polyolefin and being allowed to be peeled off from the layer of the cyclic polyolefin so that the contents in the plurality of chambers in the container can be mixed together at the time of use.
- a seal layer (easily peelable seal layer) used for a multi-chamber container of which at least one chamber chiefly uses a layer of a cyclic polyolefin as an innermost layer, the seal layer being strongly melt-adhered to the innermost layer of the cyclic polyolefin and being allowed to be peeled off from the layer of the cyclic polyolefin so that the contents in the plurality of chambers in the container can be mixed together at the time of use.
- the present invention relates to a multi-chamber container having chambers of which at least the innermost layer is made of a film of a cyclic polyolefin, wherein one chamber and another chamber are partitioned by partition walls, and the partition walls have an easily peelable seal layer containing a low-density polyethylene and a propylene/ ⁇ -olefin copolymer.
- the cyclic polyolefin layer as the innermost layer is amorphous and cannot be weakly melt-adhered to another layer.
- it is conventional to obtain an easily peelable layer by blending the same material as a container body with a different material.
- the container body and the sheet made of cyclic polyolefin blended with a material different from the cyclic polyolefin often fail to exhibit an easily peelable property or lose the easily peelable property after being stored for extended periods of time.
- the present invention uses a sheet made of a blend comprising different materials from the cyclic polyolefin, particularly, a blend of a low-density polyethylene and a propylene/ ⁇ -olefin copolymer to realize an easily peelable property that enables the contents in the container to be mixed together at the time of use while maintaining the seal strength for extended periods of time.
- the multi-chamber container is a container having a plurality of chambers, one chamber being partitioned from another chamber by a partition wall.
- a specific example may be a container in which a liquid agent container containing a liquid agent and a medicament container liquid-tightly containing a medicament are partitioned from each other by the partition wall having an easily peelable seal layer.
- the container has a pair of partition walls facing the ends on one of the two chambers, an end of the other chamber being inserted and melt-adhered between the above partition walls, and the two chambers being partitioned by the partition walls.
- At least one of the chambers of the multi-chamber container is formed by a single or multi-layered film in which at least the innermost layer is a cyclic polyolefin.
- the chambers separately contain a liquid agent, powdery agent or solid agent.
- the shape and size of the container may be different depending upon the contents.
- Other of the chambers of the multi-chamber container may be formed by a single or multi-layered film in which the innermost layer is not a cyclic polyolefin.
- the film that constitutes at least one chamber is a single-layer film or a multi-layered film having at least an innermost layer of the cyclic polyolefin.
- it is a multi-layered film comprising a first layer of the cyclic polyolefin as the innermost layer and a second layer of a linear polyolefin adjacent to the first layer.
- the cyclic polyolefin is a thermoplastic saturated norbornene-type polymer which is known (JP-A-4-276253, JP-A-5-317411, JP-A-8-155007, etc.). Specific examples thereof include polymers having structural units represented by the following chemical formula 1 and/or chemical formula 2.
- R 1 and R 2 each represent a hydrogen atom or a hydrocarbon residue having 1 to 10 carbon atoms and may be the same or different, and R 1 and R 2 together may form a ring, and n is a positive integer.
- R 3 and R 4 each represent a hydrogen atom or a hydrocarbon residue having 1 to 5 carbon atoms and may be the same or different, and R 3 and R 4 together may form a ring, l and m are positive integers, and p is 0 or a positive integer.
- the polymer having a structural unit represented by chemical formula 1 is a saturated polymer obtained from a ring-open polymer which is obtained by ring-opening polymerizing a monomer, for example, 2-norbornene and alkyl and/or alkylidene substituted derivatives thereof, such as 5-methyl-2-norbornene, 5,5-dimethyl-2-norbornene, 5-ethyl-2-norbornene, 5-butyl-2-norbornene, 5-ethylidene-2-norbornene; dicyclopentadiene, 2,3-dihydrodicyclopentadiene and derivatives thereof substituted with alkyl such as methyl, ethyl, propyl or butyl; dimethano-octahydronaphthalene and alkyl and/or alkylidene substituted derivatives thereof, such as 6-methyl-1,4:5,8-dimethano-1,4,4a,5, 6,7, 8,8a-o
- the polymer having a structural unit represented by the chemical formula 2 is a saturated polymer obtained by copolymerizing the above norbornene-type monomer and ethylene according to a known method, and/or a hydrogenated product thereof.
- the cyclic polyolefin used in the present invention may be one in which the thermoplastic saturated norbornene-type polymer is a hydrogenated product of a ring-opened polymer of a polar monomer, a copolymer of the above norbornene-type monomer and ethylene, or a hydrogenated product of the above copolymer.
- the layer composed of the cyclic polyolefin has a thickness of, usually, 3 to 5000 ⁇ m, preferably, 5 to 2000 ⁇ m and, when used as a multi-chamber container for medical use, has a thickness of, usually, 10 to 500 ⁇ m and, preferably, 20 to 300 ⁇ m.
- the second layer composed of the linear polyolefin adjacent to the first layer there can be exemplified a layer of a linear polyolefin such as low-density polyethylene, straight-chain low-density polyethylene, medium-density polyethylene, high-density polyethylene, polypropylene, or propylene/ ⁇ -olefin copolymer.
- the layer of the linear polyolefin has a thickness of, usually, 3 to 5000 ⁇ m, preferably, 5 to 2000 ⁇ m and, when used as a multi-chamber container for medical use, has a thickness of, usually, 10 to 500 ⁇ m and, preferably, 20 to 300 ⁇ m.
- the film constituting the chambers further includes a gas-barrier layer and/or a printable layer on the second layer of the linear polyolefin.
- the printable layer is one on which a medium such as a printing ink can be printed for displaying characters or patterns on the surface of the container.
- the gas-barrier layer is a layer for preventing the passage of moisture or gases.
- the printable layer in this invention is, for example, a polyester layer such as polyethylene terephthalate or a polyester layer on which an inorganic matter such as silica is deposited.
- the gas-barrier layer is, specifically, a metal foil, a metal-deposited layer or an inorganic material-deposited layer.
- the metal foil may be, for example, an aluminum foil.
- As the metal-deposited layer there can be exemplified an alumina-deposited polyester film or a nylon film.
- the inorganic material-deposited layer may be a silica-deposited polyester film.
- the films forming the chambers have been adhered together by the easily peelable seal layer.
- the easily peelable seal layer means a layer that can be easily peeled off at the time of preparing a medicine.
- the easily peelable seal layer easily peels when an external pressure is applied to the surface of one of chambers containing the contents, enabling the interiors of the plurality of chambers to communicate with each other and the contents in the containers to be mixed together.
- the partition wall for partitioning the chambers in the present invention provides a weakly melt-adhered seal portion formed of the above-mentioned easily peeling seal layer and a strongly melt-adhered seal portion.
- the weakly melt-adhered seal portion in the present invention is the easily peelable seal layer which is a composition containing the low-density polyethylene and the propylene/ ⁇ -olefin copolymer.
- the low-density polyethylene may be a low-density polyethylene obtained by polymerizing an ethylene monomer in a high-pressure radical polymerization method using a radical initiator such as an organic peroxide.
- the low-density polyethylene is a low-density polyethylene having a melt flow rate (MFR) in a range of 0.5 to 8.0 g/10 min. and a density of 0.900 to 0.930.
- ⁇ -olefin in the propylene/ ⁇ -olefin copolymer of the present invention there can be used an ⁇ -olefin having 2 or 4 to 8 carbon atoms or, specifically, ethylene, butene, pentene, hexene, heptene, octene or two or more of them.
- the propylene/ ⁇ -olefin copolymer of the present invention may specifically be a dicopolymer such as propylene/ethylene copolymer or propylene/butene copolymer, or a tercopolymer such as propylene/ethylene/butene copolymer.
- the propylene/ ⁇ -olefin copolymer of the present invention has a melting point in a range of, for example, 100° C. to 150° C.
- the mixing ratio by weight of the low-density polyethylene and the propylene/ ⁇ -olefin copolymer be 80:20 to 20:80, more preferably, 75:25 to 25:75 and, most preferably, 70:30 to 30:70.
- the amount of the low-density polyethylene exceeds 80% by weight, the weakly melt-adhered seal that is formed by the film is too strong.
- the amount thereof is less than 20% by weight, the weakly-adhered seal strength loses stability.
- the partition wall (also called an easily peelable sheet or seal layer) of the invention is prepared from a mixture of a low-density polyethylene and a propylene/ ⁇ -olefin copolymer in the usual manner.
- a method for dry-blending resin pellets in advance or a melt-blending method using a biaxial extruder there is preferably used.
- the easily peelable sheet of the present invention may be a laminated film having the easily peelable seal layer as at least one surface layer and another resin layer thereon.
- the number of said easily peelable seal layer and other resin layers is suitably selected depending upon use.
- other resins are thermoplastic resins such as straight-chain low-density polyethylene resins and cyclic polyolefin-type resins, or a mixture of these resins.
- the easily peelable sheet of the present invention can be produced in the form of a sheet by a molding method that is used for general thermoplastic resins, such as T-die molding or inflation molding. Further, the easily peelable laminated-layer sheet can be produced by co-extrusion molding, dry lamination or extrusion coating.
- the easily peelable sheet of the present invention obtained by the above methods has a thickness of about 5 to about 500 ⁇ m and, more preferably, 20 to 400 ⁇ m.
- the thickness is less than 5 ⁇ m, the strength of the film becomes insufficient and it becomes difficult to form an excellent easily peelable seal layer.
- the thickness is greater than 500 ⁇ m, on the other hand, the flexibility of the film decreases and it becomes difficult to melt-adhere the film.
- the easily peelable laminated sheet of the present invention has a thickness of 10 to 500 ⁇ m and, preferably, 20 to 400 ⁇ m.
- the portion occupied by the sheet having the easily peelable property is not smaller than 5% and, preferably, not smaller than 10% of the thickness of the sheet as a whole.
- the peeling strength of the easily peelable seal layer formed by the sheet decreases.
- strong melt-adhesion means an adhesion formed by heat-melting and adhering the films forming the chambers to liquid-tightly contain the contents therein and which cannot be peeled off by pressure exerted on the external side of the chamber.
- the melt-adhesion is accomplished, for example, at 150 to 200° C. for 1 to 3 seconds under a pressure of 0.2 to 0.5 MPa.
- T-peel strength of not smaller than 20 N/15 mm after being maintained at 60° C. for 7 weeks.
- T-peel strength for 7 days at 60° C. is equivalent to that for 180 days under room temperature.
- the weak melt-adhesion is an adhesion such that the partition wall adheres together or the partition wall adheres to the innermost layers of the films forming the chambers, and can be easily peeled off at the time of preparing a medicine.
- the partition wall comprising a blend of the low-density polyethylene and the propylene/ ⁇ -olefin copolymer is weakly melt-adhered together, or the partition wall is weakly melt-adhered to the layer of the cyclic polyolefin, for example, at 130 to 170° C. for 0.5 to 2 seconds under a pressure of 0.1 to 0.3 MPa.
- a T-peel strength is in a range of 0.5 to 3 N/15 mm after being kept at 60° C. for 7 weeks.
- a small piece of film constituting an easily peelable seal layer is strongly melt-adhered onto the innermost layer of cyclic polyolefin of one film, and then, the innermost layer of cyclic polyolefin of another film is weakly melt-adhered onto the above small piece of film.
- a small piece of film constituting the easily peelable seal layer is inserted between two films having the innermost layers of cyclic polyolefin, and a temperature differential is imparted to metal molds, so that a strong melt-adhesion is accomplished on the side of one film and a weak melt-adhesion is accomplished on the side of the other film.
- the small piece of film constituting the easily peelable seal layer is weakly melt-adhered onto the innermost layer of cyclic polyolefin of one film, and then, the other film is strongly melt-adhered onto the above small piece of film.
- the two films are weakly melt-adhered to the lower ends of the film constituting the easily peelable seal layer to thereby form a partition portion (weakly melt-adhered seal portion), and the two films are strongly melt-adhered on both the right and left sides so as not to be peeled off.
- a bag with the upper sides of the two films opening upward and the lower ends thereof forming a pair of connecting pieces facing each other.
- the connecting piece portions are opened on both the right and left sides and downward.
- the bag is filled with the medicine, and the upper portions of the two films are strongly melt-adhered together so as not to be peeled off to thereby form a chamber (see U.S. Pat. No. 5,865,309, FIG. 1A to 1D, JP-A-2003-104391, FIG. 3).
- a film constituting an easily peelable seal layer is inserted in an upper end of a tube that is opened at both ends, the tube is weakly melt-adhered to the film constituting the easily peelable seal layer to thereby form a partition portion (weakly melt-adhered seal portion), and the front and back wall portions of the tube are strongly melt-adhered so as not to be peeled off on both the right and left sides thereof.
- a connection port is inserted in the lower end of the tube and is strongly melt-adhered together so as not to be peeled off, and the remaining opening portion at the lower end of the tube is strongly melt-adhered together so as not to be peeled off.
- the small chamber is filled with a liquid through the connection port which is, then, closed with a plug to form a second small chamber (see U.S. Pat. No. 5,865,309, FIG. 2A to 2D, JP-A-2003-104391, FIG. 5).
- the two connecting piece portions of the first chamber are widely opened downward, the upper end of the second chamber is inserted in between the two connecting piece portions from the lower side, which are, then, heat-melt-adhered together to connect the two small chambers integrally together (see, U.S. Pat. No. 5,865,309, FIG. 3 and 4, JP-A-2003-104391, FIG. 6).
- the T-peel strength is measured using a universal (Instron) tester by spreading both ends of two pieces of films over 180° and holding their ends using chucks that are installed to peel. In this state, one end is pulled upward to measure the force applied to peel the melt-adhered portion.
- the strength of weak seal is set variously depending upon the size of the container or the state in which it is used. In the case of, for example, a 100-mL container for infusion, the strength of the weak seal for the peeling operation may suitably be 0.5 to 3 N/15 mm.
- a cyclic polyolefin (trade name: Zeonor manufactured by Zeon Corp.) was extruded at 250° C. to make a film A (60 ⁇ m).
- samples were cut into test pieces of a size of (15 mm ⁇ 50 mm), and were measured for their T-peel strengths to peel the small pieces of film from the film B using a universal tester (Instron).
- the T-peel strengths were also measured after the samples were stored at 60° C. for one week, three weeks and 7 weeks. The results were as shown in Table 1.
- T-peel strength between the film A and the small pieces of film was 15 N/15 mm.
- TABLE 1 T-peel strength (N/15 mm) LDPE/r-PP Just after Example (weight ratio) preparation 60° C. ⁇ 1 W 60° C. ⁇ 3 W 60° C. ⁇ 7 W 1 70/30 2.2 1.3 1.3 0.9 2 50/50 2.1 1.5 1.0 1.0 3 30/70 0.9 0.8 0.6 0.6
- a cyclic polyolefin (trade name: Zeonor manufactured by Zeon Corp.) was extruded at 250° C. to make a film A (60 ⁇ m).
- h-PP Polypropylene homopolymer TABLE 3 T-peel strength (N/15 mm) Composition Just after Comparative Example Polymer (weight ratio) preparation 60° C. ⁇ 1 W 60° C. ⁇ 3 W 60° C. ⁇ 7 W 1 LDPE (a) 100 2.6 0.3 0.2 N.D. 2 LDPE (b) 100 1.0 0.4 0.2 N.D. 3 LLDPE/r-PP 70/30 70.1 N.D. N.D. N.D. 4 LLDPE/r-PP 30/70 33.3 N.D. N.D. N.D. 5 LDPE (a)/h-PP 70/30 0.2 N.D. N.D. N.D. 6 LDPE (a)/h-PP 30/70 0.2 N.D. N.D. N.D.
- COP Cyclic polyolefin TABLE 4 T-peel strength (N/15 mm) Composition Just after Comparative Example Polymer (weight ratio) preparation 60° C. ⁇ 1 W 60° C. ⁇ 3 W 60° C. ⁇ 7 W 7 LDPE/COP 70/30 1.3 0.3 0.2 N.D. 8 LDPE/COP 80/20 1.4 0.3 0.3 N.D. 9 LDPE/COP 60/40 1.6 0.4 0.3 N.D.
- the small pieces of film using a blend of low-density polyethylene and the propylene/ ⁇ -olefin copolymer can maintain easily peelable sealing even after being stored at 60° C. for 7 weeks.
- a cyclic polyolefin (trade name: Zeonor, manufactured by Zeon Corp.) was extruded together with a medium-density polyethylene (density of 0.938) using a co-extruder at 250° C. to prepare a two-layer film (former 30 ⁇ m, latter 20 ⁇ m).
- a polyethylene terephthalate film (manufactured by Mitsubishi Kagaku Co., 12 ⁇ m thick) and a medium-density polyethylene film (density of 0.938, 40 ⁇ m thick) were successively laminated on the medium-density polyethylene layer of the two-layer film via a polyolefin-type adhesive resin to prepare a four-layer film (front film).
- a cyclic polyolefin (trade name: Zeonor manufactured by Zeon Corp.) was extruded together with the medium-density polyethylene (density of 0.938) using the co-extruder at 250° C. to prepare a two-layer film (former 30 ⁇ m, latter 20 ⁇ m)
- an aluminum foil (20 ⁇ m thick manufactured by Sun Aluminum Co.
- a polyethylene terephthalate film (16 ⁇ m thick manufactured by Toyobo Co.) were laminated using a polyurethane-type adhesive (manufactured by Takeda Pharmaceutical Co.) to obtain a two-layer laminated body.
- the aluminum foil of the two-layer laminated body was laminated via a polyolefin-type adhesive resin to prepare a four-layer film (rear film).
- the medicine chamber in the form of a bag was subjected the ⁇ -ray sterilization, aseptically filled with 1.0 g of a powdery antibiotic through an end thereof, and the end was strongly melt-adhered together to form a bag-like container.
- a small piece of film made of a blend of low-density polyethylene and propylene/ ⁇ -olefin copolymer (weight ratio of mixture: 70/30) was inserted in an upper end of a polyethylene tubular film that was opened at both ends, the tubular film was weakly melt-adhered to the above small piece of film to thereby form a partition portion (weakly melt-adhered seal portion), and the front and back wall portions, except the partition portion of the tubular film, were strongly melt-adhered so as not to be peeled off on both the right and left sides thereof.
- connection port was inserted in the lower end of the tubular film and was strongly melt-adhered together so as not to be peeled off, and the remaining opening portion at the lower end of the tubular film was strongly melt-adhered together so as not to be peeled off in order to form a second chamber.
- the non-melt-adhered portions of the medicine chamber were widely opened downward, the upper end of the second chamber was inserted between the two non-melt-adhered portions of the medicine chamber from the lower side, which were then heat-melt-adhered together to connect the two chambers integrally together.
Abstract
A multi-chamber container having chambers formed of a film of which at least an innermost layer is a cyclic polyolefin, one chamber being partitioned from another chamber by a partition wall, and the partition wall having an easily peelable seal layer which contains a low-density polyethylene and a propylene/α-olefin copolymer. The multi-chamber container enables the contents of the chambers to be mixed together.
Description
- This invention relates to a multi-chamber container having a plurality of chambers separated by a partition wall having a peelable seal layer (so-called easily peelable seal layer) and, particularly, to a multi-layered container having a plurality of chambers for medical use. More specifically, the invention relates to a multi-chamber container which enables the contents contained in a plurality of chambers to be mixed together by causing the plurality of chambers to communicate with each other upon peeling off of the partition wall having an easily peelable seal layer.
- Usually, a multi-chamber container having a plurality of small chambers for separately containing liquid agents, powder agents or solid agents has heretofore been formed by using a flexible plastic film. One chamber of a plurality of chambers is partitioned from another adjacent chamber by a partitioning wall that allows communication. The partitioning wall is such that the inner surfaces of the film forming the small chambers are directly melt-adhered together, or are melt-adhered together via an insert film held between the inner surfaces. The partitioning wall easily peels off when an external pressure is applied to the surface of the chambers containing the contents; i.e., interiors of the plurality of chambers communicate to allow the contents contained therein to be mixed together.
- As the plastic film (which includes sheet) for forming plural chambers, there has been used a two-layer film including an inner layer of a mixed resin of a straight-chain low-density polyethylene (LLDPE) and a polypropylene (PP) and an outer layer of the straight-chain low-density polyethylene (LLDPE), or a three-layer film including an inner layer of the straight-chain low-density polyethylene (LLDPE) and the polypropylene (PP), an intermediate layer of a mixed resin of the straight-chain low-density polyethylene (LLDPE) and an ethylene/α-olefin elastomer, and an outer layer of the straight-chain low-density polyethylene (LLDPE) (Japanese Patent No. 3060132, Japanese Patent No. 3079403, etc.). In these multi-layered films, the inner layers of the mixed resin of the straight-chain low-density polyethylene (LLDPE) and the polypropylene (PP) are sealed at a melt-adhesion temperature of about 110 to 130° C. to form an easily peelable seal layer, and are further sealed at a melt-adhesion temperature of about 170 to 200° C. to form a strongly melt-adhered layer.
- As the plastic film for forming plural chambers, further, there have been used an aluminum foil laminate (three-layer film of polyester/aluminum foil/polyethylene), a laminated film including a silica-deposited layer (PE/SiO2/PET/SiO2/PE) and a polyethylene tubular film (U.S. Pat. No. 5,865,309, U.S. Pat. No. 5,706,937, JP-A-2003-104391). The multi-chamber container is formed of a chamber of the aluminum foil laminate overlaid on the laminated film including the silica-deposited layer, and a chamber of the polyethylene tubular film. The plurality of such chambers are melt-adhered together via a film forming a weakly melt-adhered portion of a polymer blend of a polyethylene and a polypropylene held between the inner surfaces of the polyethylene.
- As the weakly melt-adhered portion, a resin having small melt-adhering strength to the polyethylene which is the material forming the innermost layer, for instance, a blend of a polyethylene and a resin with no compatibility thereto, is conventionally used.
- In the multi-chamber container, on the other hand, there arise such problems as a decrease in the medicament content, an increase of medicament analogues, an increased turbidity of the medicament solution and formation of insoluble fine particles which are generated by interaction of the medicine which is an effective component with impurities such as low-molecular components eluted from the linear polyolefin and components eluted from the adhesive layer.
- Under such circumstances, the present inventors have already proposed a multi-layered multi-chamber container for medical use which is formed by a multi-layered film including an innermost layer of a cyclic polyolefin or a polymer blend containing the cyclic polyolefin and a second layer of a linear polyolefin adjacent to the above layer (US 2006/0035044). The multi-layered multi-chamber container can be subjected to γ-ray sterilization, decreases the low-molecular components and adhesive components that are eluted out from the multi-layered container to eliminate the above-noted problems.
- The present invention provides a seal layer (easily peelable seal layer) used for a multi-chamber container of which at least one chamber chiefly uses a layer of a cyclic polyolefin as an innermost layer, the seal layer being strongly melt-adhered to the innermost layer of the cyclic polyolefin and being allowed to be peeled off from the layer of the cyclic polyolefin so that the contents in the plurality of chambers in the container can be mixed together at the time of use.
- The present invention relates to a multi-chamber container having chambers of which at least the innermost layer is made of a film of a cyclic polyolefin, wherein one chamber and another chamber are partitioned by partition walls, and the partition walls have an easily peelable seal layer containing a low-density polyethylene and a propylene/α-olefin copolymer.
- In this invention, the cyclic polyolefin layer as the innermost layer is amorphous and cannot be weakly melt-adhered to another layer. To impart easily peelable property to a layer, it is conventional to obtain an easily peelable layer by blending the same material as a container body with a different material. When the cyclic polyolefin is used for the container body, however, the container body and the sheet made of cyclic polyolefin blended with a material different from the cyclic polyolefin often fail to exhibit an easily peelable property or lose the easily peelable property after being stored for extended periods of time. The present invention uses a sheet made of a blend comprising different materials from the cyclic polyolefin, particularly, a blend of a low-density polyethylene and a propylene/α-olefin copolymer to realize an easily peelable property that enables the contents in the container to be mixed together at the time of use while maintaining the seal strength for extended periods of time.
- In the present invention, the multi-chamber container is a container having a plurality of chambers, one chamber being partitioned from another chamber by a partition wall. A specific example may be a container in which a liquid agent container containing a liquid agent and a medicament container liquid-tightly containing a medicament are partitioned from each other by the partition wall having an easily peelable seal layer. For example, the container has a pair of partition walls facing the ends on one of the two chambers, an end of the other chamber being inserted and melt-adhered between the above partition walls, and the two chambers being partitioned by the partition walls.
- In this invention, at least one of the chambers of the multi-chamber container is formed by a single or multi-layered film in which at least the innermost layer is a cyclic polyolefin. Usually, the chambers separately contain a liquid agent, powdery agent or solid agent. The shape and size of the container may be different depending upon the contents. Other of the chambers of the multi-chamber container may be formed by a single or multi-layered film in which the innermost layer is not a cyclic polyolefin.
- In the present invention, the film that constitutes at least one chamber is a single-layer film or a multi-layered film having at least an innermost layer of the cyclic polyolefin. Preferably, it is a multi-layered film comprising a first layer of the cyclic polyolefin as the innermost layer and a second layer of a linear polyolefin adjacent to the first layer.
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- wherein R3 and R4 each represent a hydrogen atom or a hydrocarbon residue having 1 to 5 carbon atoms and may be the same or different, and R3 and R4 together may form a ring, l and m are positive integers, and p is 0 or a positive integer.
- The polymer having a structural unit represented by chemical formula 1 is a saturated polymer obtained from a ring-open polymer which is obtained by ring-opening polymerizing a monomer, for example, 2-norbornene and alkyl and/or alkylidene substituted derivatives thereof, such as 5-methyl-2-norbornene, 5,5-dimethyl-2-norbornene, 5-ethyl-2-norbornene, 5-butyl-2-norbornene, 5-ethylidene-2-norbornene; dicyclopentadiene, 2,3-dihydrodicyclopentadiene and derivatives thereof substituted with alkyl such as methyl, ethyl, propyl or butyl; dimethano-octahydronaphthalene and alkyl and/or alkylidene substituted derivatives thereof, such as 6-methyl-1,4:5,8-dimethano-1,4,4a,5, 6,7, 8,8a-octahydronaphthalene, 6-ethyl-1,4:5,8-dimethano-1,4,4a,5,6,7,8,8a-octahydronaphthalene, 6-ethylidene-1,4:5,8-dimethano-1,4,4a,5,6,7,8,8a-octahydronaphthalene; a trimer or tetramer of cyclopentadiene, such as 4,9:5,8-dimethano-3a,4,4a-5,8,8a,9,9a-octahydro-1H-benzoindene, 5,8-methano-3a,4,4a,5,8,8a,9,9a-octahydro-1H-benzoindene, 5,8-methano-1,4,4a,4b,5,8,8a,9b-octahydro-1H-fluorene, and 4,11:5,10:6,9-trimethano-3a,4,4a,5,5a,6,9,9a,10,10a,11,11a-dodecahydro-1H-cyclopentaanthracene, and hydrogenating the ring-opened polymer by an ordinarily employed hydrogenation method.
- The polymer having a structural unit represented by the chemical formula 2 is a saturated polymer obtained by copolymerizing the above norbornene-type monomer and ethylene according to a known method, and/or a hydrogenated product thereof.
- The cyclic polyolefin used in the present invention may be one in which the thermoplastic saturated norbornene-type polymer is a hydrogenated product of a ring-opened polymer of a polar monomer, a copolymer of the above norbornene-type monomer and ethylene, or a hydrogenated product of the above copolymer.
- The layer composed of the cyclic polyolefin has a thickness of, usually, 3 to 5000 μm, preferably, 5 to 2000 μm and, when used as a multi-chamber container for medical use, has a thickness of, usually, 10 to 500 μm and, preferably, 20 to 300 μm.
- As the second layer composed of the linear polyolefin adjacent to the first layer, there can be exemplified a layer of a linear polyolefin such as low-density polyethylene, straight-chain low-density polyethylene, medium-density polyethylene, high-density polyethylene, polypropylene, or propylene/α-olefin copolymer. The layer of the linear polyolefin has a thickness of, usually, 3 to 5000 μm, preferably, 5 to 2000 μm and, when used as a multi-chamber container for medical use, has a thickness of, usually, 10 to 500 μm and, preferably, 20 to 300 μm.
- The film constituting the chambers, as required, further includes a gas-barrier layer and/or a printable layer on the second layer of the linear polyolefin. The printable layer is one on which a medium such as a printing ink can be printed for displaying characters or patterns on the surface of the container. The gas-barrier layer is a layer for preventing the passage of moisture or gases. The printable layer in this invention is, for example, a polyester layer such as polyethylene terephthalate or a polyester layer on which an inorganic matter such as silica is deposited. The gas-barrier layer is, specifically, a metal foil, a metal-deposited layer or an inorganic material-deposited layer. The metal foil may be, for example, an aluminum foil. As the metal-deposited layer, there can be exemplified an alumina-deposited polyester film or a nylon film. The inorganic material-deposited layer may be a silica-deposited polyester film.
- In the present invention, the films forming the chambers have been adhered together by the easily peelable seal layer. The easily peelable seal layer means a layer that can be easily peeled off at the time of preparing a medicine. Usually, the easily peelable seal layer easily peels when an external pressure is applied to the surface of one of chambers containing the contents, enabling the interiors of the plurality of chambers to communicate with each other and the contents in the containers to be mixed together.
- The partition wall for partitioning the chambers in the present invention provides a weakly melt-adhered seal portion formed of the above-mentioned easily peeling seal layer and a strongly melt-adhered seal portion.
- The weakly melt-adhered seal portion in the present invention is the easily peelable seal layer which is a composition containing the low-density polyethylene and the propylene/α-olefin copolymer.
- In the present invention, the low-density polyethylene may be a low-density polyethylene obtained by polymerizing an ethylene monomer in a high-pressure radical polymerization method using a radical initiator such as an organic peroxide. The low-density polyethylene is a low-density polyethylene having a melt flow rate (MFR) in a range of 0.5 to 8.0 g/10 min. and a density of 0.900 to 0.930. Examples thereof include “Petrothene” manufactured by Toso Co., “Novatec” manufactured by Japan Polyethylene Co., “Excellen” manufactured by Sumitomo Kagaku Co., “UBE Polyethylene” manufactured by Ube-Maruzen Polyethylene Co., and “Mirason” manufactured by Prime Polymer Co. As the α-olefin in the propylene/α-olefin copolymer of the present invention, further, there can be used an α-olefin having 2 or 4 to 8 carbon atoms or, specifically, ethylene, butene, pentene, hexene, heptene, octene or two or more of them. That is, the propylene/α-olefin copolymer of the present invention may specifically be a dicopolymer such as propylene/ethylene copolymer or propylene/butene copolymer, or a tercopolymer such as propylene/ethylene/butene copolymer. The propylene/α-olefin copolymer of the present invention has a melting point in a range of, for example, 100° C. to 150° C. As the propylene/α-olefin copolymers that have now been placed on the market, there can be exemplified “Novatec PP” and “Wintec” manufactured by Japan Polyethylene Co., “Excellen” manufactured by Sumitomo Kagaku Co., and polypropylenes manufactured by San Alomer Co. and Prime Polymer Co.
- It is desired that the mixing ratio by weight of the low-density polyethylene and the propylene/α-olefin copolymer be 80:20 to 20:80, more preferably, 75:25 to 25:75 and, most preferably, 70:30 to 30:70. When the amount of the low-density polyethylene exceeds 80% by weight, the weakly melt-adhered seal that is formed by the film is too strong. When the amount thereof is less than 20% by weight, the weakly-adhered seal strength loses stability.
- The partition wall (also called an easily peelable sheet or seal layer) of the invention is prepared from a mixture of a low-density polyethylene and a propylene/α-olefin copolymer in the usual manner. Though there is no particular limitation on the method for forming the mixture, there is preferably used a method for dry-blending resin pellets in advance or a melt-blending method using a biaxial extruder.
- In order to improve gas-barrier properties, easily peelable properties and mechanical properties, the easily peelable sheet of the present invention may be a laminated film having the easily peelable seal layer as at least one surface layer and another resin layer thereon. The number of said easily peelable seal layer and other resin layers is suitably selected depending upon use. Specifically, other resins are thermoplastic resins such as straight-chain low-density polyethylene resins and cyclic polyolefin-type resins, or a mixture of these resins.
- The easily peelable sheet of the present invention can be produced in the form of a sheet by a molding method that is used for general thermoplastic resins, such as T-die molding or inflation molding. Further, the easily peelable laminated-layer sheet can be produced by co-extrusion molding, dry lamination or extrusion coating.
- It is desired that the easily peelable sheet of the present invention obtained by the above methods has a thickness of about 5 to about 500 μm and, more preferably, 20 to 400 μm. When the thickness is less than 5 μm, the strength of the film becomes insufficient and it becomes difficult to form an excellent easily peelable seal layer. When the thickness is greater than 500 μm, on the other hand, the flexibility of the film decreases and it becomes difficult to melt-adhere the film.
- The easily peelable laminated sheet of the present invention has a thickness of 10 to 500 μm and, preferably, 20 to 400 μm. In the above sheet, the portion occupied by the sheet having the easily peelable property is not smaller than 5% and, preferably, not smaller than 10% of the thickness of the sheet as a whole. When the portion is not larger than 5%, the peeling strength of the easily peelable seal layer formed by the sheet decreases.
- In the present invention, strong melt-adhesion means an adhesion formed by heat-melting and adhering the films forming the chambers to liquid-tightly contain the contents therein and which cannot be peeled off by pressure exerted on the external side of the chamber. To strongly melt-adhere the layers of the cyclic polyolefin forming the innermost layer of the present invention, the melt-adhesion is accomplished, for example, at 150 to 200° C. for 1 to 3 seconds under a pressure of 0.2 to 0.5 MPa. To maintain the quality, for example, to guarantee the product for three years, it is desired to maintain a T-peel strength of not smaller than 20 N/15 mm after being maintained at 60° C. for 7 weeks.
- When it is necessary to guarantee the quality of a product sterilized with radioactive rays for 3 years, the strength at 60° C. for 7 weeks (=49 days) is conducted in compliance with Guidelines for Industrial Radiation Sterilization of Disposable Medical Products (IAEA: TEC DOC-539 (1990)) to confirm the effect in short periods of time. T-peel strength for 7 days at 60° C. is equivalent to that for 180 days under room temperature.
- In the present invention, the weak melt-adhesion is an adhesion such that the partition wall adheres together or the partition wall adheres to the innermost layers of the films forming the chambers, and can be easily peeled off at the time of preparing a medicine. The partition wall comprising a blend of the low-density polyethylene and the propylene/α-olefin copolymer is weakly melt-adhered together, or the partition wall is weakly melt-adhered to the layer of the cyclic polyolefin, for example, at 130 to 170° C. for 0.5 to 2 seconds under a pressure of 0.1 to 0.3 MPa. To maintain the quality of weakly melt-adhered seal strength, for example, it is desired that a T-peel strength is in a range of 0.5 to 3 N/15 mm after being kept at 60° C. for 7 weeks.
- There is no particular limitation on the method for forming the easily peelable seal layer of the present invention, and there can be used any conventional method for making an easily peelable seal layer. Namely, there can be exemplified the following methods.
- 1) A small piece of film constituting an easily peelable seal layer is strongly melt-adhered onto the innermost layer of cyclic polyolefin of one film, and then, the innermost layer of cyclic polyolefin of another film is weakly melt-adhered onto the above small piece of film.
- 2) A small piece of film constituting the easily peelable seal layer is inserted between two films having the innermost layers of cyclic polyolefin, and a temperature differential is imparted to metal molds, so that a strong melt-adhesion is accomplished on the side of one film and a weak melt-adhesion is accomplished on the side of the other film.
- 3) The small piece of film constituting the easily peelable seal layer is weakly melt-adhered onto the innermost layer of cyclic polyolefin of one film, and then, the other film is strongly melt-adhered onto the above small piece of film.
- There is no particular limitation on the method for producing the chambers of the multi-chamber container of the present invention, and there can be employed any conventional method concerning with the formation of such chambers. Namely, there can be exemplified the following methods.
- 1) Two films are overlaid back and front. A film constituting the easily peelable seal layer is held between the two films at a portion slightly above the lowermost end of the films and both the right and left side portions of the two films, except the lower ends thereof, are strongly melt-adhered together so as not to be peeled off. Next, the easily peelable seal layer is weakly melt-adhered to the innermost layers of the films. Thus, the upper sides of the two films form a bag that has an opening upward, and the lower end portions thereof become a pair of connecting piece portions facing each other. The connecting piece portions are opened on both the right and left sides and downward. The two films are weakly melt-adhered to the lower ends of the film constituting the easily peelable seal layer to thereby form a partition portion (weakly melt-adhered seal portion), and the two films are strongly melt-adhered on both the right and left sides so as not to be peeled off.
- Thus, there is formed a bag with the upper sides of the two films opening upward and the lower ends thereof forming a pair of connecting pieces facing each other. The connecting piece portions are opened on both the right and left sides and downward. The bag is filled with the medicine, and the upper portions of the two films are strongly melt-adhered together so as not to be peeled off to thereby form a chamber (see U.S. Pat. No. 5,865,309, FIG. 1A to 1D, JP-A-2003-104391, FIG. 3).
- 2) A film constituting an easily peelable seal layer is inserted in an upper end of a tube that is opened at both ends, the tube is weakly melt-adhered to the film constituting the easily peelable seal layer to thereby form a partition portion (weakly melt-adhered seal portion), and the front and back wall portions of the tube are strongly melt-adhered so as not to be peeled off on both the right and left sides thereof. Subsequently, a connection port is inserted in the lower end of the tube and is strongly melt-adhered together so as not to be peeled off, and the remaining opening portion at the lower end of the tube is strongly melt-adhered together so as not to be peeled off.
- Next, the small chamber is filled with a liquid through the connection port which is, then, closed with a plug to form a second small chamber (see U.S. Pat. No. 5,865,309, FIG. 2A to 2D, JP-A-2003-104391, FIG. 5).
- There is no particular limitation on the method for connecting the chambers of the present invention prepared as described above, and any widely known production method related to making such chambers can be employed. Namely, the following method can be exemplified.
- The two connecting piece portions of the first chamber are widely opened downward, the upper end of the second chamber is inserted in between the two connecting piece portions from the lower side, which are, then, heat-melt-adhered together to connect the two small chambers integrally together (see, U.S. Pat. No. 5,865,309, FIG. 3 and 4, JP-A-2003-104391, FIG. 6).
- U.S. Pat. No. 5,865,309 is incorporated herein in its entirety by reference.
- The present invention will now be specifically described by way of Examples.
- In the Examples, the T-peel strength is measured using a universal (Instron) tester by spreading both ends of two pieces of films over 180° and holding their ends using chucks that are installed to peel. In this state, one end is pulled upward to measure the force applied to peel the melt-adhered portion. The strength of weak seal is set variously depending upon the size of the container or the state in which it is used. In the case of, for example, a 100-mL container for infusion, the strength of the weak seal for the peeling operation may suitably be 0.5 to 3 N/15 mm.
- A cyclic polyolefin (trade name: Zeonor manufactured by Zeon Corp.) was extruded at 250° C. to make a film A (60 μm). On this film A (100 mm×155 mm), a small piece of film made of a blend of a low-density polyethylene (density: 0.922 g/cm3, trade name: Petrothene manufactured by Toso Co.) and a propylene/α-olefin copolymer (Tm 135° C., trade name: Novatec PP manufactured by Japan Polypropylene Co.) (weight ratios of mixture, 70/30, 50/50, 30/70, 6.0 mm×30 mm) was placed, and was strongly melt-adhered thereto for 2 seconds using a metal mold heated to a temperature of 180° C. Next, on the above small piece of film, another cyclic polyolefin film B (100 mm×155 mm) was placed and was weakly melt-adhered thereto for 1.5 seconds using a metal mold heated to a temperature of 150° C. to thereby prepare two pieces of cyclic polyolefin films (A and B) to which small film pieces had been melt-adhered.
- After being subjected to γ-ray sterilization, samples were cut into test pieces of a size of (15 mm×50 mm), and were measured for their T-peel strengths to peel the small pieces of film from the film B using a universal tester (Instron). The T-peel strengths were also measured after the samples were stored at 60° C. for one week, three weeks and 7 weeks. The results were as shown in Table 1.
- The T-peel strength between the film A and the small pieces of film (just after the preparation) was 15 N/15 mm.
TABLE 1 T-peel strength (N/15 mm) LDPE/r-PP Just after Example (weight ratio) preparation 60° C. × 1 W 60° C. × 3 W 60° C. × 7 W 1 70/30 2.2 1.3 1.3 0.9 2 50/50 2.1 1.5 1.0 1.0 3 30/70 0.9 0.8 0.6 0.6 - A cyclic polyolefin (trade name: Zeonor manufactured by Zeon Corp.) was extruded at 250° C. to make a film A (60 μm). On this film A (100 mm×155 mm), a small piece of film made of a blend of a low-density polyethylene (density: 0.926 g/cm3, trade name: UBE Polyethylene manufactured by Ube-Maruzen Polyethylene Co.) and a propylene/α-olefin copolymer (Tm 135° C., trade name: Novatec PP manufactured by Japan Polypropylene Co.) (weight ratios of mixture, 70/30, 50/50, 30/70, 60 mm×30 mm) was placed, and was strongly melt-adhered thereto for 2 seconds using a metal mold heated at a temperature of 180° C. Next, on the above small piece of film, another cyclic polyolefin film B (100 mm×155 mm) was placed and was weakly melt-adhered thereto for 1.5 seconds using a metal mold heated at a temperature of 155° C. to thereby prepare two pieces of cyclic polyolefin films (A and B) to which the small piece of film had been melt-adhered.
- After being subjected to γ-ray sterilization, samples were cut into test pieces of a size (15 mm×50 mm), and were measured for their T-peel strengths to peel the small piece of film from the film B using a universal tester (Instron). The T-peel strengths were also measured after the samples were preserved at 60° C. for one week, three weeks and 7 weeks. The results were as shown in Table 2.
TABLE 2 T-peel strength (N/15 mm) LDPE/r-PP Just after Example (weight ratio) preparation 60° C. × 1 W 60° C. × 3 W 60° C. × 7 W 4 70/30 1.6 1.0 1.0 0.6 5 50/50 1.9 1.5 0.7 0.9 6 30/70 0.6 0.6 0.6 0.6 - Samples were prepared using small pieces of film as shown in Table 3 instead of using the small piece of film used in Example 1, and by melt-adhering two pieces of cyclic polyolefin films to the small pieces of film in the same manner as in Example 1. Table 3 shows T-peel strengths between the film B and the small pieces of film. In Table 3, the abbreviations have the following meanings:
-
- LDPE(a): Low-density polyethylene having a density of 0.922 g/cm3, trade name: Petrothene manufactured by Toso Co.
- LDPE(b): Low-density polyethylene having a density of 0.926 g/cm3, trade name: UBE Polyethylene manufactured by Ube-Maruzen Polyethylene Co.
- LLDPE: Straight-chain (linear) low-density polyethylene
- r-PP: Propylene/α-olefin copolymer
- h-PP: Polypropylene homopolymer
TABLE 3 T-peel strength (N/15 mm) Composition Just after Comparative Example Polymer (weight ratio) preparation 60° C. × 1 W 60° C. × 3 W 60° C. × 7 W 1 LDPE (a) 100 2.6 0.3 0.2 N.D. 2 LDPE (b) 100 1.0 0.4 0.2 N.D. 3 LLDPE/r-PP 70/30 70.1 N.D. N.D. N.D. 4 LLDPE/r-PP 30/70 33.3 N.D. N.D. N.D. 5 LDPE (a)/h-PP 70/30 0.2 N.D. N.D. N.D. 6 LDPE (a)/h-PP 30/70 0.2 N.D. N.D. N.D. - Samples were prepared using small pieces of film as shown in Table 4 instead of using the small piece of film used in Example 1, and by melt-adhering two pieces of cyclic polyolefin films to the films in the same manner as in Example 1. Table 4 shows T-peel strengths between the film B and the small pieces of film. In Table 4, the abbreviations have the following meanings:
-
- LDPE(a): Low-density polyethylene having a density of 0.922 g/cm3, trade name: Petrothene manufactured by Toso Co.
- COP: Cyclic polyolefin
TABLE 4 T-peel strength (N/15 mm) Composition Just after Comparative Example Polymer (weight ratio) preparation 60° C. × 1 W 60° C. × 3 W 60° C. × 7 W 7 LDPE/COP 70/30 1.3 0.3 0.2 N.D. 8 LDPE/COP 80/20 1.4 0.3 0.3 N.D. 9 LDPE/COP 60/40 1.6 0.4 0.3 N.D. - As will be obvious from Tables 1 to 4, the small pieces of film using a blend of low-density polyethylene and the propylene/α-olefin copolymer can maintain easily peelable sealing even after being stored at 60° C. for 7 weeks.
- A cyclic polyolefin (trade name: Zeonor, manufactured by Zeon Corp.) was extruded together with a medium-density polyethylene (density of 0.938) using a co-extruder at 250° C. to prepare a two-layer film (former 30 μm, latter 20 μm). A polyethylene terephthalate film (manufactured by Mitsubishi Kagaku Co., 12 μm thick) and a medium-density polyethylene film (density of 0.938, 40 μm thick) were successively laminated on the medium-density polyethylene layer of the two-layer film via a polyolefin-type adhesive resin to prepare a four-layer film (front film).
- Next, a cyclic polyolefin (trade name: Zeonor manufactured by Zeon Corp.) was extruded together with the medium-density polyethylene (density of 0.938) using the co-extruder at 250° C. to prepare a two-layer film (former 30 μm, latter 20 μm) Separately, an aluminum foil (20 μm thick manufactured by Sun Aluminum Co.) and a polyethylene terephthalate film (16 μm thick manufactured by Toyobo Co.) were laminated using a polyurethane-type adhesive (manufactured by Takeda Pharmaceutical Co.) to obtain a two-layer laminated body. On the medium-density polyethylene layer of the above two-layer film, the aluminum foil of the two-layer laminated body was laminated via a polyolefin-type adhesive resin to prepare a four-layer film (rear film).
- The above four-layer film (front film) of a square shape and the above four-layer film (rear film) of a square shape were overlaid on one another, a small piece of film made of a blend of low-density polyethylene and propylene/α-olefin copolymer (weight ratio of mixture, 70/30) was held between the ends thereof, and one surface thereof was strongly melt-adhered and the other surface was weakly melt-adhered at an upper metal mold temperature of 80° C., a lower metal mold temperature of 140° C. and a pressure of 0.3 MPa. Both ends of the base end side were strongly melt-adhered together at 170° C. and a pressure of 0.3 MPa to form a medicine chamber (bag-like container 140 mm high and 115 mm wide for the medicament). A non-melt-adhered portion without the above film was left on the base end side of the two films.
- The medicine chamber in the form of a bag was subjected the γ-ray sterilization, aseptically filled with 1.0 g of a powdery antibiotic through an end thereof, and the end was strongly melt-adhered together to form a bag-like container.
- A small piece of film made of a blend of low-density polyethylene and propylene/α-olefin copolymer (weight ratio of mixture: 70/30) was inserted in an upper end of a polyethylene tubular film that was opened at both ends, the tubular film was weakly melt-adhered to the above small piece of film to thereby form a partition portion (weakly melt-adhered seal portion), and the front and back wall portions, except the partition portion of the tubular film, were strongly melt-adhered so as not to be peeled off on both the right and left sides thereof. Subsequently, a connection port was inserted in the lower end of the tubular film and was strongly melt-adhered together so as not to be peeled off, and the remaining opening portion at the lower end of the tubular film was strongly melt-adhered together so as not to be peeled off in order to form a second chamber.
- The non-melt-adhered portions of the medicine chamber were widely opened downward, the upper end of the second chamber was inserted between the two non-melt-adhered portions of the medicine chamber from the lower side, which were then heat-melt-adhered together to connect the two chambers integrally together.
- This application claims priority based on Japanese Patent Application No. 2005-264383, filed Sep. 12, 2005, which is incorporated herein by reference.
Claims (10)
1. A multi-chamber container having a plurality of chambers formed of a film of which at least an innermost layer is a cyclic polyolefin, wherein one chamber and another chamber are partitioned by a partitioning wall, and said partitioning wall comprises an easily peelable seal layer that contains a low-density polyethylene and a propylene/α-olefin copolymer.
2. The multi-chamber container according to claim 1 , wherein said easily peelable seal layer is a composition containing a low-density polyethylene and a propylene/α-olefin copolymer at a weight ratio of 80:20 to 20:80.
3. The multi-chamber container according to claim 1 , wherein said easily peelable seal layer is an easily peelable single-layer film or an easily peelable multi-layered film having an easily peelable layer on the surface thereof.
4. The multi-chamber container according to claim 1 , wherein said partition wall includes a weakly melt-adhered seal portion comprising said easily peelable seal layer and a strongly melt-adhered seal portion.
5. The multi-chamber container according to claim 1 , wherein the film constituting said plurality of chambers is a multi-layered film including a first layer of a cyclic polyolefin which is the innermost layer and a second layer of a linear polyolefin adjacent to said layer.
6. The multi-chamber container according to claim 5 , wherein the film constituting said plurality of chambers further has a gas-barrier layer and/or a printable layer on the second layer of said linear polyolefin.
7. The multi-chamber container according to claim 6 , wherein said gas-barrier layer is a metal foil, a metal-deposited layer or an inorganic material-deposited layer.
8. The multi-chamber container according to claim 6 , wherein said printable layer is a polyester layer or a polyester layer having an inorganic material-deposited thin film thereon.
9. The multi-chamber container according to claim 1 , wherein said plurality of chambers includes one for containing a liquid agent and one for containing a medicine.
10. The multi-chamber container according to claim 1 , wherein said multi-chamber container includes a pair of partition walls facing the ends on one of two chambers, an end of the other chamber is inserted and is melt-adhered between the partition walls, and the two chambers are partitioned by said partition walls.
Applications Claiming Priority (2)
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JP2005-264383 | 2005-09-12 | ||
JP2005264383 | 2005-09-12 |
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US20070062825A1 true US20070062825A1 (en) | 2007-03-22 |
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US11/516,719 Abandoned US20070062825A1 (en) | 2005-09-12 | 2006-09-07 | Multi-chamber container |
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EP (1) | EP1762379B1 (en) |
JP (1) | JP4888646B2 (en) |
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CN (1) | CN1931118B (en) |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060035044A1 (en) * | 2004-08-16 | 2006-02-16 | Kenji Omori | Multi-layered medical container and medical plural chamber container |
US20090310890A1 (en) * | 2005-06-15 | 2009-12-17 | Fujimori Kogyo Co., Ltd. | Duplex-Chamber Package |
US20100163446A1 (en) * | 2006-06-28 | 2010-07-01 | Fujimori Kogyo Co., Ltd. | Liquid container |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008136452A1 (en) * | 2007-04-27 | 2008-11-13 | Ajinomoto Co., Inc. | Double-cell container |
JP5024004B2 (en) * | 2007-12-03 | 2012-09-12 | ニプロ株式会社 | Adherent cell culture container and method for culturing adherent cells |
TW201637643A (en) * | 2015-03-25 | 2016-11-01 | Terumo Corp | Medical bag |
CN111806015A (en) * | 2020-07-20 | 2020-10-23 | 山东齐鲁乙烯化工股份有限公司 | Polypropylene high-temperature easy-to-tear food packaging film and preparation method thereof |
Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4608043A (en) * | 1984-06-22 | 1986-08-26 | Abbott Laboratories | I.V. fluid storage and mixing system |
US5267646A (en) * | 1990-11-07 | 1993-12-07 | Otsuka Pharmaceutical Factory, Inc. | Containers having plurality of chambers |
US5287961A (en) * | 1992-10-23 | 1994-02-22 | W.R. Grace & Co.-Conn. | Multi-compartment package having improved partition strip |
US5423421A (en) * | 1992-05-03 | 1995-06-13 | Otsuka Pharmaceutical Factory, Inc. | Containers having plurality of chambers |
US5706937A (en) * | 1995-04-11 | 1998-01-13 | Nissho Corporation | Flexible dual-chambered container |
US5733085A (en) * | 1996-08-06 | 1998-03-31 | Illinois Tool Works, Inc. | Fastener assembly and adhesive composition |
US5865309A (en) * | 1995-03-23 | 1999-02-02 | Nissho Corporation | Dual-chambered container and method of making same |
US6006913A (en) * | 1996-04-09 | 1999-12-28 | Bp Chemicals Plastec Gmbh | Packaging |
US6162205A (en) * | 1997-11-04 | 2000-12-19 | Mateial Engineering Technology Laboratory, Incorporated | Container for therapeutic use |
US6545096B1 (en) * | 1999-10-08 | 2003-04-08 | Nipro Corporation | Heat-resistant plastic sheet and infusion bag using the same |
US20030080129A1 (en) * | 2001-11-01 | 2003-05-01 | Hiroaki Takimoto | Small bag-shaped drug container |
US6720045B2 (en) * | 1999-12-08 | 2004-04-13 | Nipro Corporation | Easily peelable film and medical packaging container |
US20040188281A1 (en) * | 2003-03-26 | 2004-09-30 | Nipro Corporation | Medicine bag |
US20060035044A1 (en) * | 2004-08-16 | 2006-02-16 | Kenji Omori | Multi-layered medical container and medical plural chamber container |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5478617A (en) * | 1993-02-04 | 1995-12-26 | Otsuka Pharmaceutical Factory, Inc. | Multi-layer film and container |
JP3573091B2 (en) * | 1999-12-08 | 2004-10-06 | ニプロ株式会社 | Easy peelable film and medical packaging container using the same |
JP2002165862A (en) * | 2000-12-05 | 2002-06-11 | Material Eng Tech Lab Inc | Multiple-chamber container |
JP4571328B2 (en) * | 2001-04-04 | 2010-10-27 | 株式会社大塚製薬工場 | Multilayer film and container using the same |
JP3804504B2 (en) | 2001-09-28 | 2006-08-02 | ニプロ株式会社 | Container and its inspection method |
KR100592838B1 (en) * | 2002-03-14 | 2006-06-26 | 미쯔이가가꾸가부시끼가이샤 | Resin Composition for Sealant, Sealant Film and Use Thereof |
KR101009600B1 (en) * | 2003-03-12 | 2011-01-20 | 후지모리 고교 가부시키가이샤 | Multiple compartment container |
JP4412463B2 (en) * | 2003-12-11 | 2010-02-10 | 藤森工業株式会社 | Multi-chamber container |
JP4488166B2 (en) * | 2003-12-11 | 2010-06-23 | 藤森工業株式会社 | Multi-chamber package and medical multi-chamber container |
JP4420195B2 (en) * | 2003-12-11 | 2010-02-24 | 藤森工業株式会社 | Heat seal structure and multi-chamber container |
-
2006
- 2006-08-28 KR KR20060081479A patent/KR101310177B1/en active IP Right Grant
- 2006-09-07 AT AT06018777T patent/ATE454982T1/en not_active IP Right Cessation
- 2006-09-07 DE DE200660011689 patent/DE602006011689D1/en active Active
- 2006-09-07 US US11/516,719 patent/US20070062825A1/en not_active Abandoned
- 2006-09-07 EP EP20060018777 patent/EP1762379B1/en active Active
- 2006-09-08 JP JP2006244406A patent/JP4888646B2/en active Active
- 2006-09-11 TW TW95133476A patent/TWI422491B/en active
- 2006-09-12 CN CN2006101536721A patent/CN1931118B/en active Active
-
2013
- 2013-05-31 KR KR1020130062395A patent/KR20130069701A/en not_active Application Discontinuation
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4608043A (en) * | 1984-06-22 | 1986-08-26 | Abbott Laboratories | I.V. fluid storage and mixing system |
US5267646A (en) * | 1990-11-07 | 1993-12-07 | Otsuka Pharmaceutical Factory, Inc. | Containers having plurality of chambers |
US5423421A (en) * | 1992-05-03 | 1995-06-13 | Otsuka Pharmaceutical Factory, Inc. | Containers having plurality of chambers |
US5287961A (en) * | 1992-10-23 | 1994-02-22 | W.R. Grace & Co.-Conn. | Multi-compartment package having improved partition strip |
US5865309A (en) * | 1995-03-23 | 1999-02-02 | Nissho Corporation | Dual-chambered container and method of making same |
US5706937A (en) * | 1995-04-11 | 1998-01-13 | Nissho Corporation | Flexible dual-chambered container |
US6006913A (en) * | 1996-04-09 | 1999-12-28 | Bp Chemicals Plastec Gmbh | Packaging |
US5733085A (en) * | 1996-08-06 | 1998-03-31 | Illinois Tool Works, Inc. | Fastener assembly and adhesive composition |
US6162205A (en) * | 1997-11-04 | 2000-12-19 | Mateial Engineering Technology Laboratory, Incorporated | Container for therapeutic use |
US6545096B1 (en) * | 1999-10-08 | 2003-04-08 | Nipro Corporation | Heat-resistant plastic sheet and infusion bag using the same |
US6720045B2 (en) * | 1999-12-08 | 2004-04-13 | Nipro Corporation | Easily peelable film and medical packaging container |
US6815025B2 (en) * | 1999-12-08 | 2004-11-09 | Nipro Corporation | Peelable film for a medical packaging container |
US20030080129A1 (en) * | 2001-11-01 | 2003-05-01 | Hiroaki Takimoto | Small bag-shaped drug container |
US7213702B2 (en) * | 2001-11-02 | 2007-05-08 | Nipro Corporation | Small bag-shaped drug container |
US20040188281A1 (en) * | 2003-03-26 | 2004-09-30 | Nipro Corporation | Medicine bag |
US7243787B2 (en) * | 2003-03-26 | 2007-07-17 | Nipro Corporation | Medicine bag |
US20060035044A1 (en) * | 2004-08-16 | 2006-02-16 | Kenji Omori | Multi-layered medical container and medical plural chamber container |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060035044A1 (en) * | 2004-08-16 | 2006-02-16 | Kenji Omori | Multi-layered medical container and medical plural chamber container |
US20090310890A1 (en) * | 2005-06-15 | 2009-12-17 | Fujimori Kogyo Co., Ltd. | Duplex-Chamber Package |
US20100163446A1 (en) * | 2006-06-28 | 2010-07-01 | Fujimori Kogyo Co., Ltd. | Liquid container |
Also Published As
Publication number | Publication date |
---|---|
CN1931118B (en) | 2012-01-11 |
KR101310177B1 (en) | 2013-09-23 |
TW200720088A (en) | 2007-06-01 |
EP1762379A2 (en) | 2007-03-14 |
DE602006011689D1 (en) | 2010-03-04 |
KR20070030121A (en) | 2007-03-15 |
JP2007098122A (en) | 2007-04-19 |
CN1931118A (en) | 2007-03-21 |
KR20130069701A (en) | 2013-06-26 |
JP4888646B2 (en) | 2012-02-29 |
EP1762379B1 (en) | 2010-01-13 |
ATE454982T1 (en) | 2010-01-15 |
EP1762379A3 (en) | 2007-09-12 |
TWI422491B (en) | 2014-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: NIPRO CORPORATION, JAPAN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:OMORI, KENJI;KAWAMURA, SHIN-ICHI;HONDA, MINORU;REEL/FRAME:018637/0486;SIGNING DATES FROM 20060904 TO 20060907 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |