US20070065510A1 - Novel controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum - Google Patents
Novel controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum Download PDFInfo
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- US20070065510A1 US20070065510A1 US11/473,386 US47338606A US2007065510A1 US 20070065510 A1 US20070065510 A1 US 20070065510A1 US 47338606 A US47338606 A US 47338606A US 2007065510 A1 US2007065510 A1 US 2007065510A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Definitions
- the present invention relates to a controlled release device which provides sustained or pulsatile delivery of pharmaceutically active substances for a predetermined period of time.
- This invention further relates to such device in which sustained or pulsatile delivery is obtained by the unique blend and intimate mixture of pharmaceutically active substances with a microbial polysaccharide and uncrosslinked linear polymer and optionally a crosslinked polymer and/or lipophillic polymer and/or saturated polyglycolyzed glyceride.
- the invention also relates to a process for the manufacture of such devices and pharmaceutical compositions containing the same.
- a second type of pharmaceutical delivery system utilizes hydrogels either from a group consisting of uncrosslinked linear polymers or from a group consisting of crosslinked polymers.
- viscosity is the rate controlling factor for drug release kinetics.
- a gelatinous layer is formed on the surface upon hydration. The thickness and durability of this gelatinous layer depends upon the concentration, as well as the molecular weight and viscosity of the polymer in the device.
- a controlled pharmaceutical release device for use with a selected pharmaceutical to provide continuous or pulsatile therapeutically effective amounts of the pharmaceutical, the device comprising;
- the device may optionally comprise about 1 to 50% by weight crosslinked polymer, about 1 to 50% by weight lipophillic polymer and/or 1 to 50% by weight saturated polyglycolyzed glyceride.
- composition which provides controlled release of the pharmaceutical contained therein, said composition comprising;
- composition may optionally comprise about 1 to 50% by weight crosslinked polymer, about 1 to 50% by weight lipophillic polymer and/or 1 to 50% by weight saturated polyglycolyzed glide.
- a controlled release formulation of pharmaceutically active agents comprising:
- the pharmaceutically active agent is intimately mixed with a microbial polysaccharide and uncrosslinked linear polymer and further wet granulated, dried, sieved, lubricated and pressed into tablets.
- microbial polysaccharide and uncrosslinked linear polymer may be added about 1 to 50% by weight crosslinked polymer, about 1 to 50% by weight lipophillic polymer and/or 1 to 50% by weight saturated polyglycolyzed glyceride.
- compositions for delivering soluble or poorly soluble pharmaceutically active agents by deliberate and expert manipulation of the composition and ratios of a microbial polysaccharide, preferably xanthan gum, and uncrosslinked linear polymer, preferably hydroxypropylmethyl cellulose polymers, present in the device.
- the composition and ratios of the optional crosslinked polymer, preferably Carbopol 971P, and/or lipophillic polymer, preferably glyceryl behenate, and/or saturated polyglycolyzed glyceride, preferably gelucire 44/14, may also be manipulated to vary the type of release provided.
- the novel controlled delivery device of the present invention provides the controlled release of a selected pharmaceutically active agent in a sustained or a pulsatile manner.
- the device is formulated as a composition comprising pharmaceutically active agents in a sustained release matrix tablet.
- a method is provided for making the controlled release pharmaceutical delivery device.
- the present invention is simple in fabrication, permitting efficient and reproducible mass production by conventional techniques.
- the device comprises a mixture of about 1 to 60% by weight uncrosslinked linear polymers and about 1 to 60% by weight microbial polysaccharides to which about 1 to 80% by weight selected pharmaceutical active is added.
- Suitable pharmaceuticals for use in the device include but are not restricted to diltiazem, glipizide, buspirone, tramadol, gabapentin, verapamil, etodolac, naproxen, diclofenac, COX2 inhibitors, budesonide, venlafaxine, metoprolol, carbidopa, levodopa, carbamazepine, ibuprofen, morphine, pseudoephedrine, paracetamol, cisapride, pilocarpine, methylphenidine, nifedipine, nicardipine, felodipine, captopril, terfenadine, pentoxifylline, fenofibrate, aciclo
- Uncrosslinked linear polymers suitable for use in the present invention are cellulose ethers preferably hydroxypropylmethyl cellulose (HPMC).
- Suitable microbial polysaccharides for use in the invention include xanthan gum.
- the device may optionally comprise about 1 to 50% by weight crosslinked polymer, preferably Carbopol 971 P, about 1 to 50% by weight lipophillic polymer, preferably glyceryl behenate, glyceryl palmitostearate or glyceryl, and/or 1 to 50% by weight saturated polyglycolyzed glyceride, preferably gelucire 44/14.
- crosslinked polymer preferably Carbopol 971 P
- lipophillic polymer preferably glyceryl behenate, glyceryl palmitostearate or glyceryl
- saturated polyglycolyzed glyceride preferably gelucire 44/14.
- the device may optionally include about 0.5 to 10% by weight lubricants such as for example magnesium stearate and/or talc as well as about 0.5 to 10% by weight granulating or tabletting aids such as silicone dioxide, microcrystalline cellulose, calcium phosphate, sodium laurel sulphate, calcium sulphate and silicified microcrystalline cellulose.
- lubricants such as for example magnesium stearate and/or talc
- granulating or tabletting aids such as silicone dioxide, microcrystalline cellulose, calcium phosphate, sodium laurel sulphate, calcium sulphate and silicified microcrystalline cellulose.
- the device can be fabricated with any suitable pharmaceutical active as a tablet, a film coated tablet or a capsule for a ingestion.
- controlled delivery devices comprising xanthan gum and uncrosslinked linear polymers together in an intimate mixture with a pharmaceutically active agent perform efficient and optimal controlled release of the pharmaceutical active than if either polymer were to be used alone. It was also found that such delivery devices when additionally comprising crosslinked polymers and/or lipophillic polymers and/or saturated polyglycolyzed glyceride also provides efficient controlled release of the pharmaceutical active contained therein.
- Uncrosslinked linear polymers such as hydroxypropylmethyl cellulose (HPMC) tend to become more newtonian at low shear and the viscosity becomes independent of shear rate.
- Xanthan gum on the other hand displays a pseudoplastic nature in which there is a linear dependence of viscosity as function of the shear rate.
- xanthan gum has higher viscosity compared to hydroxypropylmethyl cellulose (these differences are larger at even lower shear rates) while the opposite is the case at higher shear rates.
- GIT gastrointestinal tract
- the sustained release characteristic of the composition can be predetermined and varied by adjusting the makeup of the composition within the aforesaid limits.
- the duration uniformity and continuity of release of the pharmaceutically active agent(s) can be suitably controlled by varying the relative amount of the xanthan gum and HPMC.
- Pulsatile delivery is achieved by making a unit dose such as a capsule containing a plurality of tablets or population of granules which release the active agent at different rates or at different time intervals so that, for example, if one tablet or population of granules starts releasing first and reaches a peak another can start and peak as the previous one is declining. This results in pulsatile delivery.
- a sustained release effect one population or a uniform matrix is used which releases the pharmaceutical active gradually.
- a desired rate is obtained by manipulating quantities in the composition.
- the delivery device of this invention When the delivery device of this invention is administered to the gastrointestinal tract by oral route it comes into contact with an aqueous environment and hydrates forming a gelatinous layer. During transit in the gastrointestinal tract it encounters regions of non turbulence and turbulence which presents lower shear rates and higher shear rates respectively. Matrix devices rely on the development of a viscous layer around the tablet to control diffusion of the drug from the surface and interior of the tablet. On a comparative basis xanthan gum gives higher viscosity at lower shear rates and HPMC give higher viscosity at higher shear rates.
- the present invention consist of a controlled delivery device capable of optimum performance in the GIT in which the active agent is in intimate mixture with both xanthan gum and HPMC and optionally crosslinked polymer and/or lipophillic polymer and/or saturated polyglycolyzed glyceride in a matrix.
- composition Diltiazem hydrochloride 30 Xanthan gum 30 Hydroxypropylmethyl cellulose K100M CR 38 Talc 1 Magnesium stearate 1
- Diltiazem hydrochloride was blended with xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained.
- the mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about ⁇ 2.0%.
- the dried granules were passed through a sieve #14 mesh.
- the milled granules were blended with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
- composition Diltiazem hydrochloride 30 Microcrystalline cellulose 10 Xanthan gum 25 Hydroxypropylmethyl cellulose K100M CR 33 Talc 1 Magnesium stearate 1
- Diltiazem hydrochloride was blended with microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a light shear mixer until a homogeneous mixture was obtained.
- the mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about ⁇ 2.0%.
- the dried granules were passed through a sieve #14 mesh.
- the milled granules were blended with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
- composition Glipizide 4 Microcrystalline cellulose 20 Xanthan gum 40 Hydroxypropylmethyl cellulose K100M CR 33 Silicone dioxide 1 Talc 1 Magnesium stearate 1
- Glipizide was blended with silicone dioxide, microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained.
- the mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about ⁇ 2.0%.
- the dried granules were passed through a sieve #14 mesh.
- the milled granules were blended with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
- composition Glipizide 4 Microcrystalline cellulose 20 Xanthan gum 40 Hydroxypropylmethyl cellulose K4M CR 33 Silicone dioxide 1 Talc 1 Magnesium stearate 1
- Glipizide was blended with silicone dioxide, microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained.
- the mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about ⁇ 2.0%.
- the dried granules were passed through a sieve #14 mesh.
- the milled granules were blended with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
- Naproxyn sodium was blended with microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained. This mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about ⁇ 2.0%. The dried granules were then passed through a sieve #14 mesh. The milled granules were blended with Carbopol 971P for 10 minutes, then with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
- Naproxyn sodium was blended with microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained.
- This mixture was granulated with Gelucire isopropyl alcohol solution and dried in a fluid bed dryer to a loss on drying of about ⁇ 2.0%.
- the dried granules were then passed trough a sieve #14 mesh.
- the milled granules were blended with Carbopol 971P for 10 minutes, then with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
- Verapamil hydrochloride was blended with microcrystalline cellulose, xanthan gum, hydroxypropylmethyl cellulose and Compritol in a high shear mixer until a homogeneous mixture was obtained. This mixture was granulated with isopropyl alcohol and dry in fluid bed dryer to a loss on drying of about ⁇ 2.0%. The dried granules were then passed through a sieve #14 mesh. The milled granules were blended with Carbopol 971P for 10 minutes, then with talc and magnesium stearate for 5 minutes it a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
- composition Citalopram hydrobromide 5 Lactose anhydrous 30 Microcrystalline cellulose 14 Xanthan gum 10 Hydroxypropylmethyl cellulose K100M CR 14 Carbopol 971P 5 Gelucire 44/14 10 Compritol 888 ATO 10 Talc 1 Magnesium stearate 1
- Citalopram hydrobromide was blended with microcrystalline cellulose, xanthan gum, hydroxypropylmethyl cellulose and Compritol in a high shear mixer until a homogeneous mixture was obtained. This mixture was granulated with Gelucire isopropyl alcohol solution and dry in fluid bed dryer to a loss on drying of about ⁇ 2.0%. The dried granules were then passed through a sieve #14 mesh. The milled granules were blended with Carbopol 971P for 10 minutes, then with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
Abstract
The present invention provides a controlled release device for sustained or pulsatile delivery of pharmaceutically active substances for a predetermined period of time. This invention further provides such device in which sustained or pulsatile delivery is obtained by the unique blend and intimate mixture of pharmaceutically active substance with a microbial polysaccharide and uncrosslinked linear polymer and optionally a crosslinked polymer and/or lipophillic polymer and/or saturated polyglycolyzed glyceride. The invention also provides a process for the manufacture of such devices and pharmaceutical compositions containing the same.
Description
- The present invention relates to a controlled release device which provides sustained or pulsatile delivery of pharmaceutically active substances for a predetermined period of time. This invention further relates to such device in which sustained or pulsatile delivery is obtained by the unique blend and intimate mixture of pharmaceutically active substances with a microbial polysaccharide and uncrosslinked linear polymer and optionally a crosslinked polymer and/or lipophillic polymer and/or saturated polyglycolyzed glyceride. The invention also relates to a process for the manufacture of such devices and pharmaceutical compositions containing the same.
- The prior art teaches many systems for the delivery of pharmaceutically beneficial agents. One such system operates by means of an osmotic pumping mechanism. However, it suffers from being very complex and is complicated to manufacture. A second type of pharmaceutical delivery system utilizes hydrogels either from a group consisting of uncrosslinked linear polymers or from a group consisting of crosslinked polymers. In devices using uncrosslinked polymers, viscosity is the rate controlling factor for drug release kinetics. In these systems a gelatinous layer is formed on the surface upon hydration. The thickness and durability of this gelatinous layer depends upon the concentration, as well as the molecular weight and viscosity of the polymer in the device. At higher concentrations the linear polymer chains entangle to a greater degree leading to virtual crosslinking and a stronger gel layer. Drug release is by the dissolution of polymer and erosion of the gel layer and hence the rate of erosion is what controls the release rate. Although viscosity is an important consideration in controlled drug release from hydrogel matrices, it is viscosity under low shear conditions that control diffusion through the matrix.
- Several U.S. patents are directed to the various pharmaceutical delivery systems as mentioned above, see for example U.S. Pat. Nos. 3,845,770, 3,916,899, 4,016,880, 4,160,452 and 4,200,098. While these systems do provide for the delivery of a selected pharmaceutical agent, none of these provide a controlled or pulsatile delivery of the pharmaceutical agent in which drug release is modulated by combining a microbial polysaccharide and uncrosslinked polymer. Furthermore, none of the prior art teaches a device comprising a microbial polysaccharide and uncrosslinked polymer and optionally a crosslinked polymer and/or lipophillic polymer and/or saturated polyglycolyzed glyceride.
- There was therefore a need to develop a novel controlled release pharmaceutical delivery device which could be made in a cost efficient manner and provide for either sustained or pulsatile delivery of the selected pharmaceutical incorporated therein.
- It is an object of the present invention to provide a novel controlled pharmaceutical release device capable of delivering in a controlled, continuous or pulsatile manner therapeutically effective amounts of pharmaceutically active agent for a predetermined period of time in mammals, especially human beings.
- According to an object of the present invention is a controlled pharmaceutical release device for use with a selected pharmaceutical to provide continuous or pulsatile therapeutically effective amounts of the pharmaceutical, the device comprising;
- about 1 to 60% by weight microbial polysaccharide; and
- about 1 to 60% by weight uncrosslinked linear polymer.
- The device may optionally comprise about 1 to 50% by weight crosslinked polymer, about 1 to 50% by weight lipophillic polymer and/or 1 to 50% by weight saturated polyglycolyzed glyceride.
- According to another object of the present invention is a pharmaceutical composition which provides controlled release of the pharmaceutical contained therein, said composition comprising;
- about 1 to 60% by weight microbial polysaccharide;
- about 1 to 60% by weight uncrosslinked linear polymer, and
- about 1 to 80% by weight pharmaceutical active.
- The composition may optionally comprise about 1 to 50% by weight crosslinked polymer, about 1 to 50% by weight lipophillic polymer and/or 1 to 50% by weight saturated polyglycolyzed glide.
- According to yet a further object of the present invention is a method for making a controlled release formulation of pharmaceutically active agents, said method comprising:
- blending about 1 to 80% by weight pharmaceutical active with about 1 to 60% by weight microbial polysaccharide and about 1 to 60% by weight uncrosslinked linear polymer to form a homogeneous blend;
-
- granulating said homogeneous blend and kneading to form wet granules;
- drying the wet granules to a loss on drying of about <5%;
- size reducing the dried granules to provide a granule size of about <1400 microns;
-
- blending the dried granules with about 0.5 to 10% lubricant; and
- compressing the lubricated granules into tablets.
- Preferably, the pharmaceutically active agent is intimately mixed with a microbial polysaccharide and uncrosslinked linear polymer and further wet granulated, dried, sieved, lubricated and pressed into tablets.
- Optionally, to the mixture of pharmaceutical active, microbial polysaccharide and uncrosslinked linear polymer may be added about 1 to 50% by weight crosslinked polymer, about 1 to 50% by weight lipophillic polymer and/or 1 to 50% by weight saturated polyglycolyzed glyceride.
- In a further aspect of this invention there is provided a method for delivering soluble or poorly soluble pharmaceutically active agents by deliberate and expert manipulation of the composition and ratios of a microbial polysaccharide, preferably xanthan gum, and uncrosslinked linear polymer, preferably hydroxypropylmethyl cellulose polymers, present in the device. The composition and ratios of the optional crosslinked polymer, preferably Carbopol 971P, and/or lipophillic polymer, preferably glyceryl behenate, and/or saturated polyglycolyzed glyceride, preferably gelucire 44/14, may also be manipulated to vary the type of release provided.
- The novel controlled delivery device of the present invention provides the controlled release of a selected pharmaceutically active agent in a sustained or a pulsatile manner. In one embodiment, the device is formulated as a composition comprising pharmaceutically active agents in a sustained release matrix tablet. In another embodiment, a method is provided for making the controlled release pharmaceutical delivery device.
- The present invention is simple in fabrication, permitting efficient and reproducible mass production by conventional techniques.
- The device comprises a mixture of about 1 to 60% by weight uncrosslinked linear polymers and about 1 to 60% by weight microbial polysaccharides to which about 1 to 80% by weight selected pharmaceutical active is added. Suitable pharmaceuticals for use in the device include but are not restricted to diltiazem, glipizide, buspirone, tramadol, gabapentin, verapamil, etodolac, naproxen, diclofenac, COX2 inhibitors, budesonide, venlafaxine, metoprolol, carbidopa, levodopa, carbamazepine, ibuprofen, morphine, pseudoephedrine, paracetamol, cisapride, pilocarpine, methylphenidine, nifedipine, nicardipine, felodipine, captopril, terfenadine, pentoxifylline, fenofibrate, aciclovir, zidovudine, moclobemide, potasium chloride, lamotrigine, citalopram, cladribine, loratadine, pancrelipase, lithium carbonate, orphenadrine, ketoprofen, procainamide, ferrous sulfate risperidone, clonazepam, nefazodone, lovastatin, simvastatin, pravachol, ketorolac, hydromorphone, ticlopidine, seligiline, alprazolam, divalproex and phenytoin.
- Uncrosslinked linear polymers suitable for use in the present invention are cellulose ethers preferably hydroxypropylmethyl cellulose (HPMC). Suitable microbial polysaccharides for use in the invention include xanthan gum.
- The device may optionally comprise about 1 to 50% by weight crosslinked polymer, preferably Carbopol 971 P, about 1 to 50% by weight lipophillic polymer, preferably glyceryl behenate, glyceryl palmitostearate or glyceryl, and/or 1 to 50% by weight saturated polyglycolyzed glyceride, preferably gelucire 44/14.
- The device may optionally include about 0.5 to 10% by weight lubricants such as for example magnesium stearate and/or talc as well as about 0.5 to 10% by weight granulating or tabletting aids such as silicone dioxide, microcrystalline cellulose, calcium phosphate, sodium laurel sulphate, calcium sulphate and silicified microcrystalline cellulose.
- The device can be fabricated with any suitable pharmaceutical active as a tablet, a film coated tablet or a capsule for a ingestion.
- It was unexpectedly found that controlled delivery devices comprising xanthan gum and uncrosslinked linear polymers together in an intimate mixture with a pharmaceutically active agent perform efficient and optimal controlled release of the pharmaceutical active than if either polymer were to be used alone. It was also found that such delivery devices when additionally comprising crosslinked polymers and/or lipophillic polymers and/or saturated polyglycolyzed glyceride also provides efficient controlled release of the pharmaceutical active contained therein. Uncrosslinked linear polymers such as hydroxypropylmethyl cellulose (HPMC) tend to become more newtonian at low shear and the viscosity becomes independent of shear rate. Xanthan gum on the other hand displays a pseudoplastic nature in which there is a linear dependence of viscosity as function of the shear rate. At low shear rates xanthan gum has higher viscosity compared to hydroxypropylmethyl cellulose (these differences are larger at even lower shear rates) while the opposite is the case at higher shear rates. During transit in the gastrointestinal tract (GIT) a matrix controlled delivery device encounters regions of turbulence and non turbulence. It is hypothesized that regions of non turbulence present lower shear rates to the matrix tablets, conditions for which xanthan gum demonstrates higher viscosity than HPMC while regions of turbulence present higher shear rates to the matrix tablet, conditions for which HPMC demonstrate a higher viscosity than xanthan gum. Since matrix devices rely on the development of a viscous layer around the tablet to control diffusion of the drug from the surface and interior of the tablet, the use of xanthan gum alone in a matrix tablet will presumably be more efficient in regions of non turbulence while HPMC matrices will be more efficient in regions of turbulence. However, since these tablets encounter both environmental conditions, a controlled delivery device comprising of both xanthan gum and HPMC together in intimate mixture with the pharmaceutically active agent(s) will provide optimum controlled performance.
- According to one embodiment of the present invention is the preferred form of the sustained release device which is presented as a matrix tablet that is prepared using the following steps:
- Step 1. Intimately blending a pharmaceutically active agent(s) (about 1-80% by weight) with about 1-60% by weight of xanthan gum and about 1-60% by weight of hydroxypropylmethyl cellulose (preferably Methocel™ premium grade type K100M CR or K4M CR) in a planetary or high shear mixer.
- Step 2. Granulating the homogeneous blend from stop 1 with a granulating solution (preferably isopropyl alcohol) in a planetary or high shear mixer. It is preferable to knead the wet mass for about 1-3 minutes after wet granulation.
- Step 3. Drying the wet granules in a fluid bed dryer or tray dryer to a loss on drying (LOD) of about <5%. Preferably they are dried in a tray dryer at about >40° C. to an LOD of about <2%;
- Step 4. Size reduction of the dried granules firm step 3 is done in a mill, preferably a Cone mill, such that granule size is about <1400 microns.
- Step 5. Intimately blending the milled granules with about 0.5-10% by weight of magnesium stearate and/or about 0.5 to 10% by weight talc in a V-blender.
- Step 6. The lubricated granules from step 5 are compressed into tablets using a rotary tablet press. The resulting tablets have a hardness of about >5 Strong Cobb units and a friability of about <1%.
- Step 7. Optional Other granulating or tabletting aids such as silicone dioxide, microcrystalline cellulose and calcium phosphate can be added into step 5.
- Step 8. Optional The tablet produced in step 6 can be film coated with a suitable coating. Such coatings are well known in the art of pharmaceuticals. One skilled in the art would readily comprehend the type of film coating materials and quantity that may be used in the present invention.
- Depending upon the conditions under which the materials are processed and the depending on the relative proportions of the several components, one obtains a product of unique sustained release characteristics. The sustained release characteristic of the composition can be predetermined and varied by adjusting the makeup of the composition within the aforesaid limits. The duration uniformity and continuity of release of the pharmaceutically active agent(s) can be suitably controlled by varying the relative amount of the xanthan gum and HPMC.
- Pulsatile delivery is achieved by making a unit dose such as a capsule containing a plurality of tablets or population of granules which release the active agent at different rates or at different time intervals so that, for example, if one tablet or population of granules starts releasing first and reaches a peak another can start and peak as the previous one is declining. This results in pulsatile delivery.
- For a sustained release effect one population or a uniform matrix is used which releases the pharmaceutical active gradually. A desired rate is obtained by manipulating quantities in the composition.
- When the delivery device of this invention is administered to the gastrointestinal tract by oral route it comes into contact with an aqueous environment and hydrates forming a gelatinous layer. During transit in the gastrointestinal tract it encounters regions of non turbulence and turbulence which presents lower shear rates and higher shear rates respectively. Matrix devices rely on the development of a viscous layer around the tablet to control diffusion of the drug from the surface and interior of the tablet. On a comparative basis xanthan gum gives higher viscosity at lower shear rates and HPMC give higher viscosity at higher shear rates. Therefore, the use of either xanthan gum or HPMC alone in a matrix tablet will not give an optimum performance when compared to matrix tablets comprising of both xanthan gum and HPMC together in intimate mixture with the pharmaceutically active agent(s). The present invention consist of a controlled delivery device capable of optimum performance in the GIT in which the active agent is in intimate mixture with both xanthan gum and HPMC and optionally crosslinked polymer and/or lipophillic polymer and/or saturated polyglycolyzed glyceride in a matrix.
- The examples are described for the purposes of illustration and are not intended to limit the scope of the invention.
- Methods of synthetic chemistry, pharmacy and pharmacology referred to but not explicitly described in this disclosure and examples are reported in the scientific literature and are well known to those skilled in the art.
-
% composition Diltiazem hydrochloride 30 Xanthan gum 30 Hydroxypropylmethyl cellulose K100M CR 38 Talc 1 Magnesium stearate 1 - Diltiazem hydrochloride was blended with xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained. The mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about <2.0%. The dried granules were passed through a sieve #14 mesh. The milled granules were blended with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
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% composition Diltiazem hydrochloride 30 Microcrystalline cellulose 10 Xanthan gum 25 Hydroxypropylmethyl cellulose K100M CR 33 Talc 1 Magnesium stearate 1 - Diltiazem hydrochloride was blended with microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a light shear mixer until a homogeneous mixture was obtained. The mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about <2.0%. The dried granules were passed through a sieve #14 mesh. The milled granules were blended with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
-
% composition Glipizide 4 Microcrystalline cellulose 20 Xanthan gum 40 Hydroxypropylmethyl cellulose K100M CR 33 Silicone dioxide 1 Talc 1 Magnesium stearate 1 - Glipizide was blended with silicone dioxide, microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained. The mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about <2.0%. The dried granules were passed through a sieve #14 mesh. The milled granules were blended with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
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% composition Glipizide 4 Microcrystalline cellulose 20 Xanthan gum 40 Hydroxypropylmethyl cellulose K4M CR 33 Silicone dioxide 1 Talc 1 Magnesium stearate 1 - Glipizide was blended with silicone dioxide, microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained. The mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about <2.0%. The dried granules were passed through a sieve #14 mesh. The milled granules were blended with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
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% composition Naproxyn sodium 55 Microcrystalline cellulose 10 Xanthan gum 10 Hydroxypropylmethyl cellulose K100M CR 18 Carbopol 971P NF 5 Talc 1 Magnesium stearate 1 - Naproxyn sodium was blended with microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained. This mixture was granulated with isopropyl alcohol and dried in fluid bed dryer to a loss on drying of about <2.0%. The dried granules were then passed through a sieve #14 mesh. The milled granules were blended with Carbopol 971P for 10 minutes, then with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
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% composition Naproxyn sodium 55 Microcrystalline cellulose 10 Xanthan gum 10 Hydroxypropylmethyl cellulose K100M CR 14 Gelucire 44/14 9 Talc 1 Magnesium stearate 1 - Naproxyn sodium was blended with microcrystalline cellulose, xanthan gum and hydroxypropylmethyl cellulose in a high shear mixer until a homogeneous mixture was obtained. This mixture was granulated with Gelucire isopropyl alcohol solution and dried in a fluid bed dryer to a loss on drying of about <2.0%. The dried granules were then passed trough a sieve #14 mesh. The milled granules were blended with Carbopol 971P for 10 minutes, then with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
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% composition Verapamil Hydrochloride 50 Microcrystalline cellulose 14 Xanthan gum 10 Hydroxypropylmethyl cellulose K100M CR 14 Compritol 888 ATO 10 Talc 1 Magnesium stearate 1 - Verapamil hydrochloride was blended with microcrystalline cellulose, xanthan gum, hydroxypropylmethyl cellulose and Compritol in a high shear mixer until a homogeneous mixture was obtained. This mixture was granulated with isopropyl alcohol and dry in fluid bed dryer to a loss on drying of about <2.0%. The dried granules were then passed through a sieve #14 mesh. The milled granules were blended with Carbopol 971P for 10 minutes, then with talc and magnesium stearate for 5 minutes it a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
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% composition Citalopram hydrobromide 5 Lactose anhydrous 30 Microcrystalline cellulose 14 Xanthan gum 10 Hydroxypropylmethyl cellulose K100M CR 14 Carbopol 971P 5 Gelucire 44/14 10 Compritol 888 ATO 10 Talc 1 Magnesium stearate 1 - Citalopram hydrobromide was blended with microcrystalline cellulose, xanthan gum, hydroxypropylmethyl cellulose and Compritol in a high shear mixer until a homogeneous mixture was obtained. This mixture was granulated with Gelucire isopropyl alcohol solution and dry in fluid bed dryer to a loss on drying of about <2.0%. The dried granules were then passed through a sieve #14 mesh. The milled granules were blended with Carbopol 971P for 10 minutes, then with talc and magnesium stearate for 5 minutes in a V-blender. Finally, the treated granules were pressed into tablets using a rotary tablet press.
- Although preferred embodiments have been described herein in detail, it is understood by those skilled in the art that variations may be made thereto without departing from the scope of the invention or the spirit of the appended claims.
Claims (22)
1. A controlled release pharmaceutical device which provides sustained or pulsatile delivery of pharmaceutically active substances for a predetermined period of time, the device comprising;
about 1 to 60% by weight microbial polysaccaride; and
about 1 to 60% by weight uncrosslinked linear polymer.
2. The device of claim 1 , wherein said device additionally comprises about 1 to 80% by weight pharmaceutical active.
3. The device of claim 2 , wherein said pharmaceutical active is selected from the group consisting of diltiazem, glipizide, buspirone, tramadol, gabapentin, verapamil, etodolac, naproxen, diclofenac, COX2 inhibitors, budesonide, venlafaxine, metoprolol, carbidopa, levodopa, carbamazepine, ibuprofen, morphine, pseudoephedrine, paracetamol, cisapride, pilocarpine, methylphenidine, nifedipine, nicardipine, felodipine, captopril, terfenadine, pentoxifylline, fenofibrate, aciclovir, zidovudine, moclobemide, potasium chloride, lamotrigine, citalopram, cladribine, loratadine, pancrelipase, lithium carbonate, orphenadrine, ketoprofen, procainamide, ferrous sulfate risperdone, clonazepam, nefazodone, lovastatin, simvastatin, pravachol, ketorolac, hydromorphone, ticlopidine, seligiline, alprazolam, divalproex and phenytoin.
4. The device of claim 3 , wherein said device additionally comprises at least of the agents selected from the group consisting of about 1 to 50% by weight crosslinked polymer; about 1 to 50% by weight lipophillic polymer; about 1 to 50% saturated polyglycolyzed glyceride and mixtures thereof.
5. The device of claim 4 , wherein said device additionally comprises;
about 0.5 to 10% by weight lubricant.
6. The device of claim 5 , wherein said lubricant comprises magnesium stearate or talc.
7. The device of claim 1 , wherein said microbial polysaccharide is xanthum gum.
8. The device of claim 1 , wherein said uncrosslinked linear polymer is a cellulose ether.
9. The device of claim 8 , wherein said cellulose ether is hydroxypropylmethyl cellulose.
10. The device of claim 4 , wherein said device additionally comprises about 1 to 65% granulating or tabletting aids.
11. The device of claim 10 , wherein said granulating or tabletting aids are selected from the group consisting of silicone dioxide, microcrystalline cellulose, calcium phosphate, calcium sulphate, sodium laurel sulphate, silicified microcrystalline cellulose.
12. The device of claim 4 , wherein said device is fabricated as a unit dose for pulsatile delivery of the pharmaceutical active or as a uniform matrix tablet for a sustained release of the pharmaceutical active.
13. The device of claim 12 , wherein said device is formulated as a tablet having a hardness of about >5 Strong Cobb units and a friability of about <1%.
14. A pharmaceutical composition comprising;
about 1 to 60% by weight microbial polysaccharide;
about 1 to 60% by weight uncrosslinked linear polymer; and
about 1 to 80% by weight pharmaceutical active.
15. The composition of claim 14 , wherein said composition additionally comprises at least of the agents selected from the group consisting of about 1 to 50% by weight crosslinked polymer; about 1 to 50% by weight lipophillic polymer; about 1 to 50% saturated polyglycolyzed glyceride and mixtures thereof.
16. The composition of claim 15 , wherein said composition additionally comprises about 0.5 to 10% by weight lubricant.
17. The composition of claim 16 , wherein said composition additionally comprises about 1 to 65% granulating or tabletting aids.
18. A method for making a controlled release formulation of pharmaceutically active agents, said method comprising:
blending about 1 to 80% by weight pharmaceutical active with about 1 to 60% by weight microbial polysaccharide and about 1 to 60% by weight uncrosslinked linear polymer to form a homogeneous blend;
granulating said homogeneous blend and kneading to form wet granules;
drying the wet granules to a loss on drying of about <5%;
Size reducing the dried granules to provide a granule size of about <1400 microns;
blending the dried granules with about 0.5 to 10% lubricant; and
compressing the lubricated granules into tablets.
19. The method of claim 18 , wherein at least of the agents selected from the group consisting of about 1 to 50% by weight crosslinked polymer; about 1 to 50% by weight lipophillic polymer; about 1 to 50% saturated polyglycolyzed glyceride and mixtures thereof is added to blend with said microbial polysaccharide and uncrosslinked linear polymer.
20. The device of claim 4 , wherein said crosslinked polymer is Carbopol 971P.
21. The device of claim 4 , wherein said lipophillic polymer is selected from the group consisting of glyceryl palmitostearate, glyceryl stearate and glyceryl behenate.
22. The device of claim 4 , wherein said saturated polyglycolyzed glyceride is gelucire 44/14.
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US11/473,386 US20070065510A1 (en) | 1997-10-10 | 2006-06-22 | Novel controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
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US6150197P | 1997-10-10 | 1997-10-10 | |
US09/169,409 US6607751B1 (en) | 1997-10-10 | 1998-10-09 | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
US10/438,776 US7090867B2 (en) | 1997-10-10 | 2003-09-15 | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
US11/473,386 US20070065510A1 (en) | 1997-10-10 | 2006-06-22 | Novel controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
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US11/473,386 Abandoned US20070065510A1 (en) | 1997-10-10 | 2006-06-22 | Novel controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
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US9642809B2 (en) | 2007-06-04 | 2017-05-09 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
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Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US20060024361A1 (en) * | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
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US20070298098A1 (en) * | 2005-02-16 | 2007-12-27 | Elan Pharma International Limited | Controlled Release Compositions Comprising Levetiracetam |
US20060193912A1 (en) * | 2005-02-28 | 2006-08-31 | Penwest Pharmaceuticals Co. | Controlled release O-desmethylvenlafaxine formulations |
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US9463426B2 (en) * | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
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US20080069891A1 (en) | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
US8748419B2 (en) | 2006-06-16 | 2014-06-10 | Theracos, Inc. | Treating obesity with muscarinic receptor M1 antagonists |
US7893053B2 (en) | 2006-06-16 | 2011-02-22 | Theracos, Inc. | Treating psychological conditions using muscarinic receptor M1 antagonists |
US20080131492A1 (en) * | 2006-06-23 | 2008-06-05 | Spherics, Inc. | Dosage forms for movement disorder treatment |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
JP2010510988A (en) | 2006-11-28 | 2010-04-08 | マリナス ファーマシューティカルズ | Nanoparticle formulation, method for producing the same and use thereof |
US20080220064A1 (en) * | 2006-12-06 | 2008-09-11 | Ramesh Ketkar Anant | Extended release matrix formulations of morphine |
EP2063867A2 (en) * | 2006-12-22 | 2009-06-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
CN101269056B (en) * | 2007-03-19 | 2010-05-19 | 天津药物研究院 | Metoprolol salt oral administration impulse pellet preparation |
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SG188800A1 (en) | 2007-08-23 | 2013-04-30 | Theracos Inc | Benzylbenzene derivatives and methods of use |
UA104594C2 (en) | 2008-07-15 | 2014-02-25 | Теракос, Инк. | Deuterated benzylbenzole derivatives and using thereof |
WO2010022313A2 (en) | 2008-08-22 | 2010-02-25 | Theracos, Inc. | Processes for the preparation of sglt2 inhibitors |
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WO2011080716A2 (en) | 2010-01-04 | 2011-07-07 | Wockhardt Limited | Pharmaceutical composition for modified delivery of actives |
EP2568977A1 (en) | 2010-05-11 | 2013-03-20 | Cima Labs Inc. | Alcohol-resistant metoprolol-containing extended- release oral dosage forms |
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WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
US9592288B2 (en) | 2011-02-18 | 2017-03-14 | The Scripps Research Institute | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate |
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Citations (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4016880A (en) * | 1976-03-04 | 1977-04-12 | Alza Corporation | Osmotically driven active agent dispenser |
US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
US4723958A (en) * | 1986-05-23 | 1988-02-09 | Merck & Co., Inc. | Pulsatile drug delivery system |
US4756911A (en) * | 1986-04-16 | 1988-07-12 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
US4832958A (en) * | 1985-09-30 | 1989-05-23 | Pharlyse Societe Anonyme | Galenic forms of prolonged release verapamil and medicaments containing them |
US4844905A (en) * | 1986-02-24 | 1989-07-04 | Eisai Co., Ltd. | Granule remaining in stomach |
US4891223A (en) * | 1987-09-03 | 1990-01-02 | Air Products And Chemicals, Inc. | Controlled release delivery coating formulation for bioactive substances |
US4892742A (en) * | 1985-11-18 | 1990-01-09 | Hoffmann-La Roche Inc. | Controlled release compositions with zero order release |
US4904476A (en) * | 1986-03-04 | 1990-02-27 | American Home Products Corporation | Formulations providing three distinct releases |
US5202128A (en) * | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
US5240712A (en) * | 1987-07-17 | 1993-08-31 | The Boots Company Plc | Therapeutic agents |
US5252339A (en) * | 1991-01-30 | 1993-10-12 | Alfa Wasserman S.P.A. | Pharmaceutical compositions containing orally absorbable glycosamimoglycans |
US5260069A (en) * | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
US5330766A (en) * | 1989-01-06 | 1994-07-19 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
US5415871A (en) * | 1986-01-18 | 1995-05-16 | The Boots Company Plc | Therapeutic agents |
US5425950A (en) * | 1991-10-30 | 1995-06-20 | Glaxo Group Limited | Controlled release pharmaceutical compositions |
US5472711A (en) * | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
US5527545A (en) * | 1989-09-18 | 1996-06-18 | Recordati S.A. Chemical And Pharmaceutical Company | Liquid-suspension controlled-release pharmaceutical composition |
US5760121A (en) * | 1995-06-07 | 1998-06-02 | Amcol International Corporation | Intercalates and exfoliates formed with oligomers and polymers and composite materials containing same |
US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
US6261582B1 (en) * | 1996-10-15 | 2001-07-17 | C. R. Bard, Inc. | Surgical method and composition therefor |
US6270804B1 (en) * | 1998-04-03 | 2001-08-07 | Biovail Technologies Ltd. | Sachet formulations |
US6368635B1 (en) * | 1991-04-19 | 2002-04-09 | Takeda Chemical Industries, Ltd. | Gastrointestinal mucosa-adherent matrixes pharmaceutical preparations and a coating composition |
US20020086885A1 (en) * | 1998-06-30 | 2002-07-04 | Hiroyuki Odaka | Pharmaceutical composition |
US6527051B1 (en) * | 2000-05-05 | 2003-03-04 | Halliburton Energy Services, Inc. | Encapsulated chemicals for use in controlled time release applications and methods |
US20030068370A1 (en) * | 2001-08-06 | 2003-04-10 | Richard Sackler | Pharmaceutical formulation containing irritant |
US20030068371A1 (en) * | 2001-08-06 | 2003-04-10 | Benjamin Oshlack | Pharmaceutical formulation containing opioid agonist,opioid antagonist and gelling agent |
US20030077297A1 (en) * | 1999-02-26 | 2003-04-24 | Feng-Jing Chen | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US20030118641A1 (en) * | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
US6607751B1 (en) * | 1997-10-10 | 2003-08-19 | Intellipharamaceutics Corp. | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
US20030185887A1 (en) * | 2002-03-28 | 2003-10-02 | Chih-Ming Chen | Controlled release oral dosage form of beta-adrenergic blocking agents |
US20030235616A1 (en) * | 2001-09-28 | 2003-12-25 | Sowden Harry S. | Modified release dosage form |
US20040131669A1 (en) * | 2002-12-24 | 2004-07-08 | Janez Kerc | Modified release pharmaceutical composition |
US20040185093A1 (en) * | 2003-03-18 | 2004-09-23 | Szymczak Christopher E. | Compositions containing sucralose |
US20040198775A1 (en) * | 2003-03-10 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | Methods for treating lower urinary tract disorders and the related disorders vulvodynia and vulvar vestibulitis using Cav2.2 subunit calcium channel modulators |
US20050214373A1 (en) * | 2004-03-25 | 2005-09-29 | Desai Divyakant S | Coated tablet formulation and method |
US20060017336A1 (en) * | 2003-02-10 | 2006-01-26 | Siemens Aktiengesellschaft | Electric machine with improved temperature monitoring system |
US20060018948A1 (en) * | 2004-06-24 | 2006-01-26 | Guire Patrick E | Biodegradable implantable medical devices, methods and systems |
US6991804B2 (en) * | 2000-01-25 | 2006-01-31 | Edwards Lifesciences Corporation | Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia |
US20060024361A1 (en) * | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
US20070009589A1 (en) * | 2005-07-07 | 2007-01-11 | Kandarapu Raghupathi | Extended release compositions |
US20070286902A1 (en) * | 2006-06-07 | 2007-12-13 | Abrika Pharmaceuticals | Dosage forms comprising a short acting sedative-hypnotic or salt thereof |
-
1998
- 1998-10-09 US US09/169,409 patent/US6607751B1/en not_active Expired - Lifetime
-
2003
- 2003-09-15 US US10/438,776 patent/US7090867B2/en not_active Expired - Lifetime
-
2006
- 2006-06-22 US US11/473,386 patent/US20070065510A1/en not_active Abandoned
Patent Citations (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4016880A (en) * | 1976-03-04 | 1977-04-12 | Alza Corporation | Osmotically driven active agent dispenser |
US4016880B1 (en) * | 1976-03-04 | 1983-02-01 | ||
US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
US4832958A (en) * | 1985-09-30 | 1989-05-23 | Pharlyse Societe Anonyme | Galenic forms of prolonged release verapamil and medicaments containing them |
US4892742A (en) * | 1985-11-18 | 1990-01-09 | Hoffmann-La Roche Inc. | Controlled release compositions with zero order release |
US5415871A (en) * | 1986-01-18 | 1995-05-16 | The Boots Company Plc | Therapeutic agents |
US4844905A (en) * | 1986-02-24 | 1989-07-04 | Eisai Co., Ltd. | Granule remaining in stomach |
US4904476A (en) * | 1986-03-04 | 1990-02-27 | American Home Products Corporation | Formulations providing three distinct releases |
US4756911A (en) * | 1986-04-16 | 1988-07-12 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
US4723958A (en) * | 1986-05-23 | 1988-02-09 | Merck & Co., Inc. | Pulsatile drug delivery system |
US5240712A (en) * | 1987-07-17 | 1993-08-31 | The Boots Company Plc | Therapeutic agents |
US4891223A (en) * | 1987-09-03 | 1990-01-02 | Air Products And Chemicals, Inc. | Controlled release delivery coating formulation for bioactive substances |
US5202128A (en) * | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
US5330766A (en) * | 1989-01-06 | 1994-07-19 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
US5378474A (en) * | 1989-01-06 | 1995-01-03 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
US5527545A (en) * | 1989-09-18 | 1996-06-18 | Recordati S.A. Chemical And Pharmaceutical Company | Liquid-suspension controlled-release pharmaceutical composition |
US5252339A (en) * | 1991-01-30 | 1993-10-12 | Alfa Wasserman S.P.A. | Pharmaceutical compositions containing orally absorbable glycosamimoglycans |
US6368635B1 (en) * | 1991-04-19 | 2002-04-09 | Takeda Chemical Industries, Ltd. | Gastrointestinal mucosa-adherent matrixes pharmaceutical preparations and a coating composition |
US5425950A (en) * | 1991-10-30 | 1995-06-20 | Glaxo Group Limited | Controlled release pharmaceutical compositions |
US5472711A (en) * | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
US5260069A (en) * | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
US5760121A (en) * | 1995-06-07 | 1998-06-02 | Amcol International Corporation | Intercalates and exfoliates formed with oligomers and polymers and composite materials containing same |
US6261582B1 (en) * | 1996-10-15 | 2001-07-17 | C. R. Bard, Inc. | Surgical method and composition therefor |
US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
US6607751B1 (en) * | 1997-10-10 | 2003-08-19 | Intellipharamaceutics Corp. | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
US6270804B1 (en) * | 1998-04-03 | 2001-08-07 | Biovail Technologies Ltd. | Sachet formulations |
US20020086885A1 (en) * | 1998-06-30 | 2002-07-04 | Hiroyuki Odaka | Pharmaceutical composition |
US20030077297A1 (en) * | 1999-02-26 | 2003-04-24 | Feng-Jing Chen | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US6991804B2 (en) * | 2000-01-25 | 2006-01-31 | Edwards Lifesciences Corporation | Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia |
US6527051B1 (en) * | 2000-05-05 | 2003-03-04 | Halliburton Energy Services, Inc. | Encapsulated chemicals for use in controlled time release applications and methods |
US20030118641A1 (en) * | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
US20030068370A1 (en) * | 2001-08-06 | 2003-04-10 | Richard Sackler | Pharmaceutical formulation containing irritant |
US20030068371A1 (en) * | 2001-08-06 | 2003-04-10 | Benjamin Oshlack | Pharmaceutical formulation containing opioid agonist,opioid antagonist and gelling agent |
US20030235616A1 (en) * | 2001-09-28 | 2003-12-25 | Sowden Harry S. | Modified release dosage form |
US20030185887A1 (en) * | 2002-03-28 | 2003-10-02 | Chih-Ming Chen | Controlled release oral dosage form of beta-adrenergic blocking agents |
US20040131669A1 (en) * | 2002-12-24 | 2004-07-08 | Janez Kerc | Modified release pharmaceutical composition |
US20060017336A1 (en) * | 2003-02-10 | 2006-01-26 | Siemens Aktiengesellschaft | Electric machine with improved temperature monitoring system |
US20040198775A1 (en) * | 2003-03-10 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | Methods for treating lower urinary tract disorders and the related disorders vulvodynia and vulvar vestibulitis using Cav2.2 subunit calcium channel modulators |
US20040185093A1 (en) * | 2003-03-18 | 2004-09-23 | Szymczak Christopher E. | Compositions containing sucralose |
US20050214373A1 (en) * | 2004-03-25 | 2005-09-29 | Desai Divyakant S | Coated tablet formulation and method |
US20060018948A1 (en) * | 2004-06-24 | 2006-01-26 | Guire Patrick E | Biodegradable implantable medical devices, methods and systems |
US20060024361A1 (en) * | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
US20070009589A1 (en) * | 2005-07-07 | 2007-01-11 | Kandarapu Raghupathi | Extended release compositions |
US20070286902A1 (en) * | 2006-06-07 | 2007-12-13 | Abrika Pharmaceuticals | Dosage forms comprising a short acting sedative-hypnotic or salt thereof |
Non-Patent Citations (2)
Title |
---|
Rasve et al. "Pulsatile drug delivery system", Int'l Journal of Pharma and Bio Science, vol. 2, Issue 3 (Sept. 2011) * |
Yang "Xanthan gum fermentation by xanthomonas campestris immobilized in a novel centrifugal fibrous-bed bioreactor", dept. of chemical engineering, the Ohio State Univ., Biotechol. Prog. 1996, 12. pp 630-637 (see introduction at page 630). * |
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Also Published As
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---|---|
US6607751B1 (en) | 2003-08-19 |
US20040009219A1 (en) | 2004-01-15 |
US7090867B2 (en) | 2006-08-15 |
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