US20070106327A1 - Tissue opening occluder - Google Patents
Tissue opening occluder Download PDFInfo
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- US20070106327A1 US20070106327A1 US11/584,828 US58482806A US2007106327A1 US 20070106327 A1 US20070106327 A1 US 20070106327A1 US 58482806 A US58482806 A US 58482806A US 2007106327 A1 US2007106327 A1 US 2007106327A1
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- occluder
- anchor assembly
- tissue
- opening
- pfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00592—Elastic or resilient implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00597—Implements comprising a membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00615—Implements with an occluder on one side of the opening and holding means therefor on the other
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
Abstract
A tissue opening occluder comprising first and second occluder portions, each occluder portion including a frame structure and an attachment structure to attach one portion to the other portion. The frames may be utilized to constrain the tissue between the two portions enough to restrict the significant passage of blood therethrough. The frame portions may be covered by a fabric suspended from a perimeter thereof. The occluder portions are conjoined at least one point on each portion.
Description
- This is a divisional application of U.S. patent application Ser. No. 10/209,797, filed Jul. 30, 2002, which claims benefit of U.S. Provisional Patent Application Serial Nos. 60/309,337; 60/309,376; and 60/309,418; all having a filing date of Aug. 1, 2001, all of which are hereby incorporated by reference in their entirety.
- 1. Field of the Invention
- The present invention generally relates to devices for occluding a tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device deliverable via a catheter to the site of a tissue opening.
- 2. Description of the Related Art
- The device of the subject invention, in all its embodiments, may be utilized for the occlusion of many types of tissue openings, such as septal defects and PFO, and the like. For the sake of clarity, the present invention may, at times, be described specifically in the context of occlusion of a PFO. This specific description, however, should not be taken to limit the scope of the possible applications of the present invention.
- The term “patent foramen ovale” generally refers to the failure to close a normal opening between the left and right atria (i.e., upper chambers) of the heart. Typically, a foramen ovale is a flap-like opening between the left and right atria of the heart which persists long after birth. Commonly, the foramen ovale has one flap extending from the top of the atrial chamber and another flap extending from the bottom of the atrial chamber, wherein the two flaps meet or overlap each other. Specifically, a PFO is typically located between the atrial septum primum and secundum at the location of the fossa ovalis. The opening provides a path to allow blood to bypass the lungs in an unborn infant, since the lungs are not in use during that period. The foramen ovale typically becomes functionally closed after the birth of the infant due to greater pressure from the increased blood flow in the left atrium acting upon the flap. However, in humans, for example, as many as 1 in 5 people have foramen ovale that do not fully close. In the absence of other cardiac defects or unusual cardiac pressures, the open foramen ovale does not present a substantial problem. However, in patients having circulatory problems-wherein the pressure on the right side of the heart is increased, for example as the result of congenital heart disease, blood may begin to flow through the foramen ovale. This result may also occur, for example, in divers when experiencing an increase in pressure due to being under water. The presence of a significantly large PFO, a flap structure that cannot provide sufficient seal, or a significant increase in pressure can cause blood to shunt across the defect from the right atrium to the left atrium and hence on to the left ventricle, aorta, and brain. If the defect is not closed, the risk of stroke is increased. Shunting of blood from the left to the right side can also have negative, consequences, such as cardiac failure or hemoptysis.
- Tissue openings have traditionally been corrected by open heart surgery which required the surgeon to open the chest of a patient and bypass the heart temporarily. The surgeon would then physically cut into the heart and suture the opening closed. In the case of larger defects, a patch of a biologically compatible material would be sewn onto the tissue to cover the opening. However, the risk of complications occurring during such an intricate procedure presents substantial problems that patients would rather avoid.
- In order to avoid such complications and the long recovery times associated with open heart surgery, a variety of trans-catheter closure techniques have been implemented. In such techniques, an occluding device is delivered through a catheter to the site of the tissue opening. Once the occlusion device is positioned adjacent the opening, it must be attached to the tissue wall containing the opening in a manner that permits it to effectively block the passage of blood through the opening. Furthermore, the occlusion device must also adjust to the anatomy or structure of the PFO, commonly a tunnel like structure, the width and length of which varies substantially between patients. As has been documented in the literature, the trans-catheter techniques developed thus far have had drawbacks associated therewith.
- For example, a variety of heretofore known devices require assembly at the situs of the tissue opening. That is to say separable or separate halves of the device are deployed and subsequently united so as to traverse or span the tissue opening in furtherance of closure. Some well known devices require threading or “buttoning” of the discrete device elements. Additionally, such devices require special delivery and/or deployment tools, making their utility less than desirable.
- A further shortcoming in the art yet to be adequately and fully addressed is the issue of device positioning at the situs and, more particularly, re-positioning in furtherance of effectuating a proper seal of the tissue opening. Also not addressed is the ability to retrieve the device from the situs without damage thereto. Heretofore, known devices appear to evidence a broad functionality, namely that of occlusion, or more pointedly, plugging a tissue opening without a full or more developed functionality of the constituents or substructures of the device, e.g., a device which includes a single occluder reversibly secured in place by an anchor assembly.
- Heretofore known self expanding devices tend to be structurally complex, expensive to produce and cumbersome to load, unload, and reliably position at the situs of a tissue opening, and insensitive to the variable requirements of the PFO tunnel geometry. The balance or tension between the structural integrity of the device, its “size” (e.g., bulk, rigidity, etc.), and ability to remain optimally positioned continues to be a critical consideration, cardiac devices being subject to the rhythmic pumping of the heart, on the order of 100,000 beats per day.
- The present invention addresses the needs of the field, as well as other problems associated with the prior art. The present invention offers advantages over the prior art and solves problems associated therewith.
- The present invention is a tissue opening occluder which preferably has first and second portions. Both portions include a frame. One or both of the portions may have means for attaching the two portions together. Each of the frame portions is placed or positioned on one of opposite sides of a tissue wall to occlude the opening enough to restrict the significant passage of blood therethrough. One or both of the frame portions may also have a fabric support structure and have fabric suspended from a perimeter thereof. The fabric preferably is of such a type that it promotes the growth of tissue on the surface of or within the fabric. The portions may be directly attached together, attached by means of an attachment structure that is independent of either portion, may be conjoined at a single point or at a plurality of points, or may be attached by their frame and/or fabric elements. One or both of the portions may be formed in different shapes or may be identically configured.
- In a first embodiment of the subject invention, the portions or halves of the occlusion device are configured as occluding panels, namely reversibly expandable elements which cooperatively engage opposing wall portions in the vicinity of the tissue defect (e.g., structures which are positioned in each atrium). Such occluding panels may be substantially planar or may have a significant third dimension. A variety of linkages are contemplated for integrating or otherwise joining the panels such that the sought after device responsiveness is obtained.
- In a first alternate embodiment of the subject invention, one half of the occlusion device may be configured as an occluding panel (i.e., atrium engaging element), having two or three dimensions, while the second half may comprise a planar wire anchor structure which is configured to resiliently occupy a body structure, such as a PFO “tunnel,” in furtherance of stabilizing the occluder panel portion of the device. The anchoring or positioning member may utilize one or more hook structures for engaging tissue surrounding the opening.
- In yet a further embodiment of the subject invention, the device is adapted to be received and retained exclusively within the PFO “tunnel,” no structure thereof extending into the atrium. The anchor structure stabilizes an occluding panel such that the panel “bridges” the portions of the septum within the area of the defect.
- The present invention is thus an improved device over structures known in the prior art. More specific features and advantages obtained in view of those features will become apparent with reference to the drawing figures and DETAILED DESCRIPTION OF THE INVENTION.
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FIGS. 1 and 2 are side views of tissue opening occluders of the present invention, particularly illustrating the cooperative engagement of a pair of occluder panels; -
FIGS. 3-9 illustrate a representative variety of operative engagements contemplated for the structures of the present invention; -
FIG. 10 illustrates a side view of an anchored occluder of the subject invention sealing a PFO; -
FIG. 10A is a plan view of the device ofFIG. 10 ; -
FIG. 11 illustrates the anchor structure ofFIG. 10A ; -
FIG. 12-23 illustrate alternate embodiments of the device ofFIG. 10 ,FIG. 13 illustrating only the anchor portion of the device in combination with linkage structure; -
FIG. 24 illustrates yet a further embodiment of the tissue opening occluder of the present invention, in side view, in a deployed condition; and, -
FIGS. 25-26 illustrate embodiments of the occluder panel ofFIG. 24 . - As a preliminary matter, the subject invention contemplates three general configurations, several styles of each shown and subsequently described in the figures. The first general configuration for the tissue opening occluder (e.g., those illustrated in
FIGS. 1-9 ) is characterized by paired occluder panels which are operatively joined so as to permit a high degree of motion, including rotation. The occluder panels are positioned within each atrium so as to “patch” (i.e., overlay) the septum in the vicinity of the defect, each occluder panel being in relative tension (i.e., being drawn towards each other). The second general configuration for the tissue opening occluder (e.g., that structure illustrated inFIGS. 10-23 ) is characterized by a single occluder panel, functioning in a similar capacity as heretofore described, anchored by a substantially planar wire structure positionable for retention within the “tunnel” of the PFO (i.e., overlapping septal portions). A third configuration for the tissue opening occluder (e.g., those illustrated inFIGS. 24-26 ) is characterized by its deployed, occluding position, specifically its retention within a defect such that the device is effectively contained within a tunnel of a PFO so as to greatly reduce, if not eliminate, passage (i.e., shunting) of blood from the right to left atrium. Finally, a variety of advantageous linkages, namely those ofFIGS. 3-9 , facilitating operative engagement between the major structural elements of the several embodiments, are provided. - Referring generally to
FIGS. 1 and 2 , there is illustrated a first general configuration for the subject reversibly deployabletissue opening occluder 30 which includes first and second portions, more particularly, anoccluder panel 32 and ananchor assembly 34 extending therefrom, each of these structures being intended to be opposingly paired about a tissue opening of a type as illustrated inFIG. 10 . Theanchor assembly 34 of this general configuration comprises a panel similar to the occluder panel, however not necessarily identical therewith, which is joined, at least indirectly, to theoccluder panel 32 via alinkage 44. Theoccluder panel 32 includes afabric support structure 36 andfabric 38 supported by a perimeter thereof. The fabric support structure may include the wire frame, the linkage, or both. The wire frame can be of many shapes and is preferably made of superelastic wire, preferably Nitinol. The wire “frames preferably have a predetermined shape which is restored after deployment of the wire frame through a delivery catheter. The fabric is secured to the fabric support structure by suturing or other methods known in the art. The fabric is biocompatible and preferably supports tissue ingrowth so as to stabilize the implanted device at the implant site. Suitable fabrics include polyester, ePTFE, and other appropriate materials. Preferably, but not necessarily, theoccluder panel 32 may embrace the panel styles disclosed in U.S. Pat. Nos. 6,214,029, 6,440,152, 6,551,344, each of which are incorporated herein by reference. As will be later detailed, once theoccluder panel 32 is reliably positioned relative to the septal wall (e.g., within the left atrium), it may be anchored to the tissue wall via the anchor assembly 34 (i.e., positioning and deployment of the proximal anchor in abutting engagement with the septum within the right atrium), thereby eliminating the flow or shunting of blood through the opening or passageway. - Referring now to
FIGS. 3-9 , a variety oflinkages 44 are illustrated for the occluder panel/anchor assembly. Each of these structures provide resilient directional translation and rotation for one half of the device with respect to the other. The key consideration is the responsiveness of theoccluder panel 32 with and to, theanchor assembly 34 during engagement of theoccluder panel 32 with the tissue opening. - The
linkage 44 may take the form of extra winds on conjoint eyelets 46 (FIG. 3 ) and the eyelets may be enlarged. The linkage may include one or more fibers of material such as a suture or wire (FIG. 4-9 ). The suture may be a wire suture and may be made of Nitinol. Thelinkage 44 may more particularly include a wire structure such as a loop, coil, or spring, such as a coil spring or a leaf spring. Thelinkage 44 may have opposing ends terminating in loops or eyelets to facilitate connection to each of the halves of the device. Furthermore, greater than one linkage may be provided between theoccluder panel 32 and the anchor assembly 34 (FIG. 7 , see alsoFIG. 1 in which the anchor assembly is configured similarly to the occluder panel). - Referring now to
FIGS. 10 and 10 A, an alternate configuration of the tissueopening occlusion device 30 of the subject invention is illustrated in a fully deployed condition, fully engaged with portions of a tissue wall adjacent an opening or passage therethrough, (e.g., foramen ovale) so as to effectively block blood flow through the passage. The reversibly deployabletissue opening occluder 30 generally includes first and second halves, more particularly, anoccluder panel 32 and ananchor assembly 34 extending therefrom. Theoccluder panel 32 includes afabric support structure 36 and fabric 38 (not shown inFIGS. 10 and 10 A) supported by a perimeter thereof. Preferably, but not necessarily, theoccluder panel 32 may embrace the panel styles previously noted. As will be later detailed, once theoccluder panel 32 is reliably positioned relative to the septal wall, it may be anchored to, or at least relative to, the tissue wall via theanchor assembly 34, thereby eliminating the flow or shunting of blood through the opening or passageway. - The
anchor assembly 34 ofFIGS. 10-23 generally includes awire anchor element 40 of generally planar configuration adapted to be selectively manipulatable in furtherance of positioning and securing theoccluder panel 32 at a tissue opening situs. Thewire anchor element 40, as shown, is intended to be positioned and retained within a characteristic “tunnel” of the PFO, as for instance by expansion of the structure into tensioned engagement with portions of the tunnel. Thewire anchor element 40, as will be later discussed in detail, is at least indirectly linked to acentral portion 42 of thefabric support structure 36, theoccluder panel 32 andanchor assembly 34 being thereby opposingly urged into engagement with the tissue opening in furtherance of closure of the tissue opening or passage. As will become evident, it is preferred that thewire anchor element 40 have a portion configured to snugly fit against a portion of the tissue wall, and that at least a portion of thewire anchor element 40 be wide enough to anchor or set theoccluder panel 32 in place despite the forces being applied to the device generally by the fluid running through the structure (e.g., heart, vessel, etc.) in which the device is placed. It is to be further understood that thewire anchor element 40 may itself be a fabric support structure (i.e., function to suspend fabric from at least a perimeter thereof), to the extent that the addition or inclusion of fabric is advantageous in furtherance of “setting,” in a long term sense, the anchoring assembly (i.e., pseudo-assimilation of the structure to the tissue: further adherence of the structure to the tissue) post device deployment, or advantageous in immediate closure of the passage such as by clotting. - The
anchor assembly 34 of thetissue opening occluder 30 further includes linkage 44 (not shown inFIGS. 10 and 10 A) which joins thewire anchor element 40 to or with theoccluder panel 32. Thislinkage 44 may be integral to thewire anchor element 40, as illustrated for instance inFIGS. 10 and 11 , or may be a separate, discrete structure, see for instanceFIG. 15 , which is interposed between thewire anchor element 40 and theoccluder panel 32. Generally, the functionality of the linkage is to permit a resilient multi-directional (i.e., in the Cartesian coordinate sense, namely the x, y, z directional senses) spacing of the device portions. It is advantageous that thewire anchor element 40 possess a high degree of freedom with respect to its motion relative to theoccluder panel 32. In addition to the aforementioned x, y, and z motion, the ability to account for rotation (i.e., torsion) is desirable. It is preferable that the linkage be capable of reversible elongation. Theoccluder portions occluder panel 32, or, alternatively, conjoined at a plurality of discrete points, located or positioned within the bounds or adjacent the perimeter of each of thehalves 32, 34 (i.e., within an area bounded by each perimeter of thephysical structures 32, 34), or on thefabric 38 as applications warrant. - As an integral component of the
wire anchor element 40, thelinkage 44, more particularly the physical point of connection of theoccluder panel 32 to thewire anchor element 40, is preferably an eyelet 46 (i.e., a loop) as shown inFIGS. 1 and 2 . Similarly, thecentral portion 42 of thefabric support structure 36 of theoccluder panel 32 preferably includeseyelet 46, or a plurality of eyelets, for engaging thelinkage 44 of theanchor assembly 34. It is to be understood that as used herein, the term “eyelet” refers generally and broadly to a loop without limitation (e.g., round, elongate, angular, single, multiple (i.e., coil), etc.). In addition to convenient connection means, the eyelets impart a further resiliency or spring-like quality to the structures into which they are incorporated, thereby fortifying the cooperative action of the anchor assembly with the occluder panel. - As is appreciated with reference to the figures, the planar
wire anchor element 40 preferably, but not necessarily, has a periphery that extends out into the atria when positioned in furtherance of device anchoring. More particularly, thewire anchor element 40 is oriented substantially parallel to the tissue wall. The anchor profile should be low so that tissue can grow into the implant and so that the implant does not cause flow disturbance or facilitate clot formation. It is preferred in these embodiments, that the angle of difference between the tissue wall and the wire anchor element be less than 45 degrees, but more preferably may be less than 15 degrees. This angle of difference is preferably measured from the central axis of the tissue wall. - Anchor shapes are provided which offer capability to conform to the geometry of a PFO tunnel and resistance to inadvertent ejection from the tunnel in the direction of the occluder panel. The PFO tunnel generally ranges from 3-10 mm in width and 1-20 mm in length and is generally flat in height with no thickness under “at rest” conditions. Anchors such as those shown in
FIGS. 12, 14 , 16, 17, 21 and 22 offer superior ability to conform to different or variable tunnel widths. Further, the generally planar geometry of anchors shown inFIGS. 12-23 conform to the generally planar geometry of the PFO tunnel. Further, anchors such as those shown inFIGS. 14, 15 , 17, 19 and 21 offer superior resistance to ejection from the PFO tunnel once fully or partially deployed in the tunnel due to a portion of the anchor frame being substantially parallel to the occluder panel (as shown in the figures). Finally, designs such as the anchor inFIGS. 17 and 21 provide superior accommodation of variable PFO tunnel lengths while maintaining a frame edge that, when deployed, will resist ejection from the tunnel - It is further advantageous, however not necessary, that the
anchor assembly 34, more particularly thewire anchor element 40, include one or more hooks 48 (e.g., FIGS. 16/16A) for attachment of theanchor assembly 34 to the tissue wall. In devices so equipped, the portion of thewire anchor element 40 having the hook or hooks 48 formed therein, or extending therefrom, will extend substantially parallel to the tissue wall. The one or more hooks may be formed, carried and/or arranged on or with respect to thewire anchor element 40 in any suitable manner known in the art. For example, as shown in FIGS. 16/16A, thewire anchor element 40 is formed having ahook 48 on an end opposite the attachment point of the twohalves wire anchor element 40 will be generally aligned along the surface of the tissue wall (i.e., in conformity therewith) when thehook 48 thereof is engaged in the wall. - As previously noted, the
occluder panel 32 comprises afabric support structure 36 andfabric 38 supported or suspended by a perimeter thereof. Thefabric support structure 36 of theoccluder panel 32 is generally flexible and elastically deformable.Fabric 38, which may be formed of a thin, flexible material which can be folded and pulled taut without being damaged, is suspended or otherwise affixed to the perimeter of thefabric support structures 36. It may be desirable to provide an excess of fabric to thepanel 32 or theanchor 40 so as to facilitate collapse of the fabric carrying structure into a catheter. - The
fabric 38 is preferably a relatively porous material. While this may seem to contradict the purpose of the device, blood will tend to coagulate on the latticework provided by the porous material. Blood flow across the tissue opening is usually substantially blocked after minimal time passage. If so desired, thefabric 38 of theoccluder panel 32 may be treated with a thrombogenic agent to speed this natural process, or may be impregnated with a biocompatible polymeric compound or the like to make it relatively impervious to fluids. - The primary purpose of using a porous fabric is to accelerate the process of permanently anchoring the device in place. The support structures hold the fabric tautly and in intimate contact with the surface of the tissue wall. This intimate contact between the tissue wall and perimeter of the occluder permits ingrowth of collagen and fibrous tissue from the tissue wall into the fabric. Over time, the membrane resting against the tissue wall will become securely anchored to the wall and be covered by a layer of endothelial cells. Elastic polymeric materials such as, for example, polyester knit, nylon, polypropylene, polytetrafluoroethylene (e.g., TEFLON®), and expanded polytetrafluoroethylene (e.g., GORETEX(®), as well as natural fabrics such as silk, are suitable materials for covering the
fabric support structure 36 of theoccluder panel 32. - To accommodate the need of the
fabric support structure 36 to distort when retrieving thedevice 30 into a catheter, excess fabric can be provided. On an area basis relative to the support structure, an excess of fabric in the range, typically, of about 30-35 percent, and up to 50 percent, is sufficient. This range is required because the low stretch characteristics of the fabric prevent the support structure from collapsing in a manner suitable to get into the catheter. However, a 30 denier polyester knit is advantageous in that it possesses a low stretch character, is approximately 50% less bulky than known jersey style knit patterns which facilitates the use of smaller delivery catheters, and allows for the device of the subject invention to be retrieved into such catheters at forces that are not detrimental to either the catheter or the device (e.g., a 40 mm occluder may be pulled into a 12 French catheter using a reasonable peak force of about four pounds). - The
fabric 38 may be attached to supportstructures 36, orwire anchor element 40 as the case may be, by any suitable means. For instance, thefabric 38 may be directly attached to thesupport structures 36 by means of an adhesive or the like, or the periphery of thefabric 38 may be wrapped about thesupport structures 36 and the peripheral edge attached to the rest of the fabric so as to essentially define a sleeve about thesupport structures 36. In the latter instance, the sleeve may fit the support structure relatively loosely so that the structure may move within the sleeve with respect to the fabric. The peripheral edge of the fabric may be affixed to the rest of thefabric sheet 38 in any suitable fashion such as by sewing. Preferably, though, the periphery of the fabric can be sewn to at least some portion of the perimeter segments of thesupport structures 36 using a polyester, non-adsorbable suture or the like. - The planar
wire anchor element 40 and thefabric support structure 36 are preferably formed of a flexible, elastically deformable material such as a biocompatible metal, metal alloy or polymer, most preferably a superelastic material. One such material currently known in the art is a near-stoichiometric nickel/titanium alloy, commonly referred to as Nitinol or NiTi. Such superelastic materials may be elastically deformed to a much greater extent than most other materials, yet substantially fully recover their original shape when released. This permits the frame to be deformed sufficiently for insertion into, and passage through, a small-diameter catheter, yet automatically elastically return to its initial shape upon exiting the catheter. - The frame portions are preferably manufactured with nitinol wire that can be wound around the pins of a forming die and subjected to heat treatment. The wire may be bent through greater than 360 degrees to form the loops or eyelets. The ends of the wire may be attached to each other in any secure fashion, such as by means of welding, a suitable biocompatible cementitious material, or by any means known in the art. For example, the wire ends of each frame half can be connected with a titanium hypo tube using a compression crimp. Titanium is more ductile than nitinol, providing a reliable grip with excellent corrosion resistance, thereby making this method suitable for joining the ends of the material. Alternately, the preferred forms for the fabric support and/or the wire anchor element may be cut out from a sheet of such superelastic material as a single structure, by chemical etching, punching with a suitable punch and die, or any other appropriate forming method.
- In order to enhance radiopacity so that the device can be viewed remotely during deployment, either the
fabric support structure 36 or the wire anchor element (or both) may be provided with a radiopaque coating, such as gold or platinum. For instance, the wire may be plated with a thin layer of gold or platinum. For instance, a helically wound length of a thin radiopaque wire may be placed over the wire, alternatively, radiopaque marking bands, which are commercially available, may be employed. By placing one such band on segments of device structures, a physician can remotely visualize the frame as a plurality of small bands; when the bands are appropriately spaced from one another on a monitor, the physician knows that the frame is properly deployed. Alternatively, the fabric support structures can be made of wire with a radiopaque core. - With general reference to
FIGS. 12-23 , alternate embodiments of thetissue opening occluder 30 of the subject invention are illustrated, more particularly numerous configurations for the anchor assemblies 34 (e.g., the planar wire anchor elements 40): an “eye” (FIGS. 12 and 13 ); “mushroom heads” (FIGS. 14, 15 , 16, and 18); lobed elements (FIGS. 19-21); and the styles which are the subject ofFIGS. 1, 2 , 17, 22 and 23. The embodiments ofFIGS. 15-18 show adiscrete linkage 44 interposed between theoccluder panel 32 and theanchor assembly 34 so as to define a non-stressed spaced apart condition for said structures. -
FIGS. 24-26 illustrate a further embodiment of the tissue opening occluder of the present invention in a deployed configuration.FIGS. 25 and 26 illustrate the construction of theoccluder panel 32. Thepanel 32 includes afabric support structure 36 which is shown as having a plurality ofeyelets 46 formed therein. Afabric swatch 38 is mounted to thefabric support structure 36 in an appropriate manner such as by means of suturing (not shown). -
FIGS. 25 and 26 illustrate ananchor element 40. As discussed generally herein with regard to all embodiments, upon theoccluder panel 32 being deployed into position within the PFO infudibulum, theanchor element 40 can be allowed to spring into an expanded configuration in which it operatively functions to hold theoccluder panel 32 in position within the infudibulum. - The
anchor element 40 ofFIGS. 24-26 is a generally straight wire segment which, when to be deployed from, for example, a catheter (not shown), springs to its operational configuration at least in secure engagement with heart tissue. In some instances, however, theanchor element 40 would spring into, and pass through, the heart tissue. That is the disposition illustrated inFIG. 24 . - It will be understood that the fabric support structure can, in some embodiments, comprise a single continuous wire made of nitinol. A structure employing multiple nitinol sections, however, can also be utilized.
- The swatch of fabric is made of any appropriate material discussed hereinbefore. In any case, the material of which it is made will function to promote tissue growth within the PFO infudibulum.
- It will be understood that insertion of the
occluder panel 32 into the PFO infudibulum will be accomplished in a manner known in the prior art. Typically, a nitinol fabric support structure would be positioned within a deployment catheter in a contracted configuration. After the catheter has been inserted through a patient's vasculature to arrive at the PFO, it can be deployed in an appropriate manner known in the prior art. Appropriate deployment techniques are taught in U.S. Pat. Nos. 6,214,029, 6,440,152, 6,551,344. Those techniques are hereby incorporated by reference. - Although the foregoing has focused on application of the present invention to occlude atrial PFO, the invention is not limited to occluding only foramen ovale. For instance, the instant occlusion device can be used to treat atrial septal defect, ventricular septal defect, patent ductus arteriosus, or any other congenital or acquired orificial or tubular communications between vascular chambers or vessels.
- While a preferred embodiment of the present invention has been described, it should be understood that various changes, adaptations and modifications may be made therein without departing from the spirit of the invention. Changes may be made in details, particularly in matters of shape, size, material, and arrangement of parts without exceeding the scope of the invention. Accordingly, the scope of the invention is as defined in the language of the appended claims.
Claims (20)
1. A method of deploying a tissue opening occluder in an opening in a tissue wall, the method comprising:
positioning a distal portion of a catheter carrying a tissue opening occluder having an occluder panel and a substantially planar anchor assembly extending from the occluder panel at a location proximate an opening in a tissue wall;
deploying the occluder panel of the tissue opening occluder from the distal portion of the catheter into engagement with a first side of the tissue wall, the occluder panel having a first end and a second end opposite the first end; and
deploying the anchor assembly into engagement with a second side of the tissue wall such that the anchor assembly extends through the tissue opening and is biased toward only one of the first end and the second end of the occluder panel, said occluder panel and said anchor assembly being thereby opposingly urged into engagement with the tissue wall.
2. The method of claim 1 , wherein the opening in the tissue wall is a patent foramen ovale (PFO).
3. The method of claim 2 , wherein the anchor assembly is deployed in a tunnel of the PFO.
4. The method of claim 2 , further comprising conforming the substantially planar geometry of the anchor assembly to a generally planar geometry of the PFO tunnel.
5. The method of claim 1 , wherein the anchor assembly is positioned generally parallel with the tissue wall when fully deployed.
6. The method of claim 1 , further comprising positioning the anchor assembly such that the anchor assembly is at an angle relative to the tissue wall of less than 15 degrees.
7. The method of claim 1 , wherein the occluder panel comprises a fabric support structure supporting a fabric on a perimeter thereof.
8. A method of occluding an opening in a tissue wall between first and second atria of a heart, the opening having a generally planar geometry, the method comprising:
advancing a deployment catheter carrying a tissue opening occluder comprising an occluder panel and an anchor assembly extending therefrom to a location proximate to the tissue wall;
deploying the occluder panel from the deployment catheter such that the occluder panel is in engagement with one side of the tissue wall; and
deploying the anchor assembly such that it is placed within the tissue opening and extends through the opening between the first and second atria of the heart, the anchor assembly having a substantially planar geometry conforming to the generally planar geometry of the tissue opening;
wherein said anchor assembly and said occluder panel are biased to be substantially parallel when deployed.
9. The method of claim 8 , wherein the deployment catheter is advanced to a location proximate to a patent foramen ovale (PFO).
10. The method of claim 9 , wherein the anchor assembly is deployed such that it is positioned substantially entirely within a tunnel of the PFO.
11. The method of claim 8 , further comprising positioning the anchor assembly such that it is at an angle relative to the tissue wall of less than 15 degrees.
12. The method of claim 8 , wherein the anchor assembly comprises a planar wire frame anchor.
13. The method of claim 12 , wherein the occluder panel and anchor assembly are made from nitinol wire.
14. A method of occluding a patent foramen ovale (PFO) in a body of a patient, the method comprising:
delivering a tissue opening occluder having an occluder panel and a substantially planar anchor assembly to the PFO; and
deploying the tissue opening occluder by positioning the occluder panel in an atrium of the patient and positioning the anchor assembly on an opposite side of a septum of the PFO such that the anchor assembly is positioned in a tunnel of the PFO, the substantially planar anchor assembly substantially conforming to a generally planar geometry of the tunnel of the PFO, wherein the occluder panel and the anchor assembly engage opposite sides of the septum in furtherance of positioning and securing the tissue opening occluder.
15. The method of claim 14 , wherein the occluder panel is deployed in the left atrium of the patient.
16. The method of claim 14 , wherein the anchor assembly is deployed into a position substantially parallel to a septum wall.
17. The method of claim 14 , wherein the anchor assembly and the occluder panel are biased to be substantially parallel when deployed.
18. The method of claim 14 , wherein an angle between the septum wall and the anchor assembly when fully deployed is less than 15 degrees
19. The method of claim 14 , wherein the anchor assembly further comprises at least one anchor for anchoring the assembly with tissue of the PFO.
20. The method of claim 14 , wherein the tissue opening occluder is delivered with a catheter.
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Also Published As
Publication number | Publication date |
---|---|
DE60231757D1 (en) | 2009-05-07 |
US7887562B2 (en) | 2011-02-15 |
EP1602332A1 (en) | 2005-12-07 |
EP1281355A2 (en) | 2003-02-05 |
EP1281355B1 (en) | 2005-09-21 |
US7582103B2 (en) | 2009-09-01 |
DE60206226D1 (en) | 2005-10-27 |
US20070112382A1 (en) | 2007-05-17 |
US7288105B2 (en) | 2007-10-30 |
US20030028213A1 (en) | 2003-02-06 |
EP1602332B1 (en) | 2009-03-25 |
US20080058866A1 (en) | 2008-03-06 |
ATE304813T1 (en) | 2005-10-15 |
DE60206226T2 (en) | 2006-06-29 |
EP1281355A3 (en) | 2003-02-26 |
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