US20070201993A1 - Disposable pumping apparatus based on flexible vessels in pressurized containers - Google Patents
Disposable pumping apparatus based on flexible vessels in pressurized containers Download PDFInfo
- Publication number
- US20070201993A1 US20070201993A1 US11/680,308 US68030807A US2007201993A1 US 20070201993 A1 US20070201993 A1 US 20070201993A1 US 68030807 A US68030807 A US 68030807A US 2007201993 A1 US2007201993 A1 US 2007201993A1
- Authority
- US
- United States
- Prior art keywords
- fluid
- flexible
- vessel
- interior
- rigid container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
- F04B43/10—Pumps having fluid drive
- F04B43/113—Pumps having fluid drive the actuating fluid being controlled by at least one valve
- F04B43/1136—Pumps having fluid drive the actuating fluid being controlled by at least one valve with two or more pumping chambers in parallel
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
- F04B43/10—Pumps having fluid drive
- F04B43/113—Pumps having fluid drive the actuating fluid being controlled by at least one valve
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C5/00—Methods or apparatus for filling containers with liquefied, solidified, or compressed gases under pressures
- F17C5/06—Methods or apparatus for filling containers with liquefied, solidified, or compressed gases under pressures for filling with compressed gases
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C9/00—Methods or apparatus for discharging liquefied or solidified gases from vessels not under pressure
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2203/00—Vessel construction, in particular walls or details thereof
- F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
- F17C2203/068—Special properties of materials for vessel walls
- F17C2203/0685—Special properties of materials for vessel walls flexible
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
- F17C2205/01—Mounting arrangements
- F17C2205/0123—Mounting arrangements characterised by number of vessels
- F17C2205/013—Two or more vessels
- F17C2205/0134—Two or more vessels characterised by the presence of fluid connection between vessels
- F17C2205/0146—Two or more vessels characterised by the presence of fluid connection between vessels with details of the manifold
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
- F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
- F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
- F17C2205/0323—Valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
- F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
- F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
- F17C2205/0341—Filters
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
- F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
- F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
- F17C2205/0352—Pipes
- F17C2205/0364—Pipes flexible or articulated, e.g. a hose
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2221/00—Handled fluid, in particular type of fluid
- F17C2221/05—Ultrapure fluid
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
- F17C2227/01—Propulsion of the fluid
- F17C2227/0128—Propulsion of the fluid with pumps or compressors
- F17C2227/0135—Pumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
- F17C2227/01—Propulsion of the fluid
- F17C2227/0128—Propulsion of the fluid with pumps or compressors
- F17C2227/0135—Pumps
- F17C2227/0142—Pumps with specified pump type, e.g. piston or impulsive type
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
- F17C2227/01—Propulsion of the fluid
- F17C2227/0128—Propulsion of the fluid with pumps or compressors
- F17C2227/0157—Compressors
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
- F17C2227/01—Propulsion of the fluid
- F17C2227/0128—Propulsion of the fluid with pumps or compressors
- F17C2227/0171—Arrangement
- F17C2227/0185—Arrangement comprising several pumps or compressors
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2250/00—Accessories; Control means; Indicating, measuring or monitoring of parameters
- F17C2250/06—Controlling or regulating of parameters as output values
- F17C2250/0605—Parameters
- F17C2250/0636—Flow or movement of content
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2270/00—Applications
- F17C2270/02—Applications for medical applications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2270/00—Applications
- F17C2270/05—Applications for industrial use
Abstract
An apparatus is provided for intended use in pumping a fluid under sterile conditions. In one embodiment, a first rigid container is internally pressurized to pump fluid through a first flexible vessel within the rigid container. In another embodiment, first and second containers are provided, each for receiving flexible vessels that create independent pumping chambers upon the selective or periodic internal pressurization of the containers. Related aspects and methods are also provided.
Description
- This application claims the benefit of U.S. Provisional Patent App. Ser. No. 60/777,376, filed Feb. 28, 2006, the disclosure of which is incorporated herein by reference.
- The present invention relates generally to fluid pumping and, more particularly, to a disposable pumping apparatus.
- A number of applications in the bioprocessing industry exist where process fluids must be pumped from one location or vessel to another in a sterile, non-invasive and measured fashion. Such pumping must occur in multiple upstream and downstream applications. Typical upstream pumping applications include: buffer preparation, media preparation, bioreactor media feed and supplement addition. Typical downstream applications include pumping the cell suspensions, protein solutions or buffers to or through purification devises such as centrifuges, filters, membranes, chromatography columns or formulation and fill vessels.
- It is advantageous to use disposable pumps in the above pumping applications in an effort to eliminate cross contamination risks between the batches, as well as to reduce cleaning and validation downtime and overall manufacturing cost for biopharmaceuticals. One popular disposable pumping technology in the bioprocess industry is a peristaltic pump. In one form, such as is shown in U.S. Pat. No. 3,737,251 (the disclosure of which is incorporated herein by reference to the extent not inconsistent with the present teachings), such a pump uses a flexible tube as a pumping chamber, as well as the pumping line to move the fluid from one location to another. Compressing the tube with a driving head produces the desired pumping action.
- Despite the number of advantages of the peristaltic pump which include simplicity, low cost and sterility, limitations restrict the usage of such a pump in a number of important bioprocessing steps. These include relatively low pressure, low flow rate and pulsations of the transported liquid. For these reasons, such pumps are rarely used in applications such as cross flow filtration or chromatography columns.
- Accordingly, a need is identified for a pumping apparatus that addresses and overcomes the foregoing limitations, while still being disposable and usable under sterile conditions.
- In accordance with a first aspect of the invention, an apparatus for intended use in pumping a fluid under sterile conditions is disclosed. The apparatus comprises a first rigid container having an interior capable of being pressurized (either positively or negatively). A first flexible vessel is positioned at least partially within the interior of the first rigid container, and includes an outlet for discharging the fluid. At least one pressure source, such as a gas cylinder, compressor, or even a vacuum pump, is provided for pressurizing the interior of the rigid container to cause the fluid to move through the outlet of the flexible vessel.
- In one embodiment, the apparatus further includes a feed vessel connected to an inlet of the first flexible vessel, as well as a pump for delivering the fluid from the feed vessel to an inlet of the first flexible vessel. A filter may also be provided for receiving fluid from the outlet of the first flexible vessel, along with a return line for delivering fluid from the filter to the feed vessel. Preferably, the pressure created in the interior of the first rigid container comprises hydrostatic pressure to create a substantially constant flow of fluid through the outlet of the first flexible vessel.
- In this or another embodiment, the apparatus may further comprise a second container having an interior capable of being pressurized by the pressure source, as well as a second flexible vessel for positioning at least partially within the second container. The second flexible vessel further includes an outlet for discharging the fluid to a line in common with the outlet of the first flexible vessel. Preferably, the pressure source alternately pressurizes the first and second containers, such as through the use of valves.
- In accordance with another aspect of the invention, an apparatus for intended use in pumping a fluid is provided. The apparatus comprises at least two containers, each having an interior capable being pressurized. A flexible vessel is positioned at least partially within the interior of each container and is capable of receiving and holding the fluid. Each flexible vessel further includes an outlet. At least one pressure source is provided for selectively pressurizing the interiors of the containers to cause the fluid to move through the outlets of the corresponding flexible vessels.
- Preferably, the pressure source alternatively pressurizes the containers. The apparatus may further include a common line connected to the outlets of the flexible vessels, or a feed vessel for feeding fluid to the inlets of the flexible vessels. In the latter case, a filter may receive fluid from the outlet of one or both of the flexible vessels, and a return line may be provided for returning fluid from the filter to the feed vessel. Alternatively, a chromatography column may be provided for receiving fluid from the outlets of the flexible vessels.
- In accordance with still another aspect of the invention, a method of pumping a fluid is disclosed. The method comprises providing the fluid in a first flexible vessel positioned at least partially within a first rigid container, and pressurizing an interior of the first rigid container to pump the fluid from the first flexible vessel. The method may further include the steps of at least partially relieving the pressure in the first rigid container, allowing fluid to enter the first flexible vessel through an inlet, and then pressurizing the interior of the first rigid container. Alternatively or additionally, the method may further include the steps of delivering the fluid to a second flexible vessel positioned at least partially within a second rigid container, and pressurizing an interior of the second rigid container to pump the fluid from the second flexible vessel.
- In accordance with yet a further aspect of the invention, a method of pumping a fluid is disclosed. The method comprises delivering the fluid to a first flexible vessel positioned at least partially within an interior of a first rigid container; pressurizing the interior of the first rigid container to move fluid through an outlet of the first flexible vessel; delivering the fluid to a second flexible vessel positioned at least partially within an interior of a second rigid container; and pressurizing the interior of the second rigid container to move fluid through an outlet of the second flexible vessel.
- Preferably, the step of delivering the fluid to the second flexible vessel is concurrent with the step of pressurizing the first rigid container. The delivering step may comprise delivering step comprises delivering fluid from a common feed vessel. The method may further include the step of delivering the fluid from the outlet of the first or second flexible vessel to a filter, and then delivering the fluid to a vessel for feeding either the first or second flexible vessel. Preferably, the pressurizing steps are performed to create a substantially constant flow of fluid along a common line associated with the outlets of the flexible vessels.
-
FIG. 1 is a schematic diagram of one pumping apparatus forming one aspect of the invention; -
FIG. 2 is a schematic diagram of a pumping apparatus forming another aspect of the invention; -
FIGS. 3a and 3b are graphical illustrations of the flow rate versus time created from the use of a pumping apparatus ofFIG. 1 or 2; -
FIGS. 4, 5 , and 6 schematically illustrate various configurations usable with the disclosed pumping apparatus. - In accordance with one aspect of the invention, the general nature of the proposed pumping apparatus comprises a container capable of being pressurized, such as for example with a periodically oscillating internal pressure. The pressure is of a hydrostatic nature and maybe created by introducing gas or fluid media to the interior of the pressure container. A hermetically closed or scaled collapsible container, such as a flexible bag, is placed at least partially and preferably entirely inside the pressure container. When used in connection with pumping sterile fluids or fluids under sterile conditions, the outer surface of the flexible vessel is in contact with pressure transferring media and need not be sterile, but the inner surface of the flexible vessel may be in contact with the pumped sterile fluid so it must also be sterile.
- When the pressure container is periodically or selectively pressurized, the flexible vessel then works as a fluid pumping chamber The flexible vessel and the chamber have an inlet port and a discharge port. The pumped fluid is introduced into the flexible vessel by an inlet port connected to an inlet line (such as flexible tubing) via an inlet valve. The pumped fluid discharges from the flexible vessel via the discharge port connected to a discharge line by a discharge valve. These lines may penetrate into the pressure container, which may be hermetically sealed from the outside environment in the entire range of the pressure developed inside the container.
- To illustrate and describe a more specific and preferred implementation, and with reference to
FIG. 1 , one embodiment of thepumping apparatus 10 includes twoflexible vessels flexible vessels rigid pressure containers - Both
pressure containers valves - Preferably,
valves flexible vessels valves Vent valves rigid pressure containers low pressure pump 23 may be used to fill thepumping chambers pump 21 may comprise a peristaltic pump. - Operation of the
pumping apparatus 10 described above may proceed as outlined in the following description. During the initial cycle, the pumping chamber formed by one of theflexible vessels 11 is filled with a fluid, such as a liquid, preferably to capacity. Pumping chamber formed by the otherflexible vessel 12 may be initially empty.Fluid valves valves vent valve 20 is open, whilevent valve 19 is closed. - Initially,
pressure valve 22 is open whilevalve 21 is closed. Accordingly, pressure developed inpressure container 13 results in the discharge of the fluid from thevessel 11 through the outlet line. Since the pressure in thecontainer 13 remains constant, the flow rate of the fluid pumped is also constant until all the fluid from thevessel 11 is pumped out and it collapses. During this cycle, the other pressure chamber withinvessel 12 maybe filled to capacity with fluid by thepump 23. - Once pumping
chamber 12 is filled to capacity with the fluid and pumping chamber ofvessel 11 is empty,fluid valves valves valve 20 is closed whilevalve 19 is opened, andpressure valve 22 is closed whilevalve 21 is open. The pressure developed in therigid container 14 results in discharge of the fluid from the pressure chamber ofvessel 12 through the outlet line. During this cycle, pressure chamber ofvessel 11 is filled to capacity with fluid, such as by thepump 23. - Turning now to
FIG. 2 , this alternative embodiment of thepumping apparatus 10 is similar in many respects to the embodiment inFIG. 1 . However, thelow pressure pump 23 on theFIG. 1 is replaced withvacuum pump 24 that creates negative pressure in thepressure containers pump 24 is connected to thepressure containers valves containers flexible vessels 11, 12 (provided, of course, the associatedvalves - The sequence of pumping actions in an arrangement of two
flexible vessels rigid containers FIG. 3a .FIG. 3b shows the resultant flow rate in the discharge line D of the pumping apparatus 10 (see alsoFIG. 1 ). The resultant flow rate is constant as long as the spikes resulting from switching from one pumping chamber to another can be minimized by proper synchronization of the valves. - Turning to
FIG. 4 , an illustration is provided of a pre-sterilized (by means of gamma radiation or other methods) disposableflexible bag assembly 40 consisting of the feed bag serving as the vessel V containing the fluid to be pumped and twopumping vessels pumping vessels assembly 40 maybe introduced into the tworigid pressure containers pumping apparatus 10 shown onFIG. 1 orFIG. 2 to pump the fluid from the feed bag. -
FIG. 5 shows a pre-sterilized (by means of gamma radiation or other methods)disposable bag assembly 50 consisting of a bag as the feed vessel V with the fluid to be pumped, twoflexible pumping vessels pumping vessels assembly 50 maybe introduced into thepressure containers pumping apparatus 10 shown inFIG. 1 orFIG. 2 for re-circulation of the fluid from the feed bag serving as the feed vessel V, through the filter F, and back again. - Illustrated in FIGS. 6 is a
disposable bag assembly 60 connected to a chromatography column C. As inFIG. 5 , the bag serving as the feed vessel V contains the fluid to be processed.Flexible vessels pumping apparatus 10 shown inFIG. 1 orFIG. 2 to activate the pumping of the fluid through the chromatography column C. In one embodiment, the chromatography column C can be re-usable. In another embodiment, thebag assembly 60 and the column C are single use components. - In the embodiments of
FIGS. 1 and 2 , thepumping apparatus 10 is based on two chambers created by separateflexible vessels - The foregoing descriptions of various embodiments of the present inventions have been presented for purposes of illustration and description. These descriptions are not intended to be exhaustive or to limit the invention to the precise forms disclosed. All the pumping apparatuses described above may have single-use fluid path components and thus eliminate cleaning sterilization and validation procedures. The embodiments described provide the best illustration of the principles of the invention and its practical applications to thereby enable one of ordinary skill in the art to utilize the invention in various embodiments and with various modifications as are suited to the particular use contemplated.
Claims (23)
1. An apparatus for intended use in pumping a fluid under sterile conditions, comprising:
a first rigid container having an interior capable of being pressurized;
a first flexible vessel positioned at least partially within the interior of the first rigid container and for receiving and holding the fluid, said first flexible vessel having an outlet; and
at least one pressure source for pressurizing the interior of the rigid container to cause the fluid to move through the outlet of the first flexible vessel.
2. The apparatus of claim 1 , further including a feed vessel connected to an inlet of the first flexible vessel.
3. The apparatus of claim 2 , further including a pump for delivering the fluid from the feed vessel to an inlet of the first flexible vessel.
4. The apparatus of claim 2 , further including a filter for receiving fluid from the outlet of the first flexible vessel, and a return line for delivering fluid from the filter to the feed vessel.
5. The apparatus of claim 1 , wherein the pressure created in the interior of the first rigid container comprises hydrostatic pressure.
6. The apparatus of claim 1 , further comprising a second container having an interior capable of being pressurized by the pressure source and a second flexible vessel for positioning at least partially within the second container, said second flexible vessel having an outlet for discharging the fluid to a line in common with the outlet of the first flexible vessel.
7. The apparatus of claim 6 , wherein the pressure source alternately pressurizes the first and second containers.
8. The apparatus of claim 1 , wherein the at least one pressure source comprises a vacuum pump.
9. An apparatus for intended use in pumping a fluid under sterile conditions, comprising:
at least two containers, each having an interior capable being pressurized;
a flexible vessel positioned at least partially within the interior of each container and for receiving and holding the fluid, each said flexible vessel having an outlet; and
at least one pressure source for selectively pressurizing the interiors of the containers to cause the fluid to move through the outlets of the corresponding flexible vessels.
10. The apparatus of claim 9 , wherein the pressure source alternatively pressurizes the containers.
11. The apparatus of claim 9 , further including a common line connected to the outlets of the flexible vessels.
12. The apparatus of claim 9 , further including a feed vessel for feeding fluid to the inlets of the flexible vessels.
13. The apparatus of claim 12 , further including a filter for receiving fluid from the outlet of one or both of the flexible vessels, and a return line for returning fluid from the filter to the feed vessel.
14. The apparatus of claim 9 , further including a chromatography column for receiving fluid from the outlets of the flexible vessels.
15. The apparatus of claim 9 , wherein the at least one pressure source comprises a vacuum pump.
16. A method of pumping a fluid, comprising:
providing the fluid in a first flexible vessel positioned at least partially within a first rigid container; and
pressurizing an interior of the first rigid container to pump the fluid from the first flexible vessel.
17. The method of claim 16 , further including the steps of at least partially relieving the pressure in the first rigid container, allowing fluid to enter the first flexible vessel through an inlet, and then pressurizing the interior of the first rigid container.
18. The method of claim 16 , further including the steps of delivering the fluid to a second flexible vessel positioned at least partially within a second rigid container, and pressurizing an interior of the second rigid container to pump the fluid from the second flexible vessel.
19. A method of pumping a fluid, comprising:
delivering the fluid to a first flexible vessel positioned at least partially within an interior of a first rigid container;
pressurizing the interior of the first rigid container to move fluid through an outlet of the first flexible vessel;
delivering the fluid to a second flexible vessel positioned at least partially within an interior of a second rigid container; and
pressurizing the interior of the second rigid container to move fluid through an outlet of the second flexible vessel.
20. The method of claim 19 , wherein the step of delivering the fluid to the second flexible vessel occurs concurrently with the step of pressurizing the first rigid container.
21. The method of claim 19 , wherein the delivering step comprises delivering fluid from a common feed vessel.
22. The method of claim 19 , further including the step of delivering the fluid from the outlet of the first or second flexible vessel to a filter, and then delivering the fluid to a vessel for feeding either the first or second flexible vessel.
23. The method of claim 19 , wherein the pressurizing steps are performed to create a substantially constant flow of fluid along a common line associated with the outlets of the flexible vessels.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/680,308 US20070201993A1 (en) | 2006-02-28 | 2007-02-28 | Disposable pumping apparatus based on flexible vessels in pressurized containers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77737606P | 2006-02-28 | 2006-02-28 | |
US11/680,308 US20070201993A1 (en) | 2006-02-28 | 2007-02-28 | Disposable pumping apparatus based on flexible vessels in pressurized containers |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070201993A1 true US20070201993A1 (en) | 2007-08-30 |
Family
ID=38459812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/680,308 Abandoned US20070201993A1 (en) | 2006-02-28 | 2007-02-28 | Disposable pumping apparatus based on flexible vessels in pressurized containers |
Country Status (2)
Country | Link |
---|---|
US (1) | US20070201993A1 (en) |
WO (1) | WO2007101248A2 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090130757A1 (en) * | 2005-10-26 | 2009-05-21 | Terentiev Alexandre N | Bioreactor with mixer and sparger |
US20090129201A1 (en) * | 2000-10-09 | 2009-05-21 | Terentiev Alexandre N | Mixing Bag or Vessel Having a Fluid-Agitating Element |
US20090219780A1 (en) * | 2005-10-04 | 2009-09-03 | Jose Castillo | Mixing System Including a Flexible Bag, Specific Flexible Bag and Locating System for the Mixing System |
US20100197003A1 (en) * | 2004-01-07 | 2010-08-05 | Terentiev Alexandre N | Bioreactor |
US20100290308A1 (en) * | 2000-10-09 | 2010-11-18 | Terentiev Alexandre N | Systems using a levitating, rotating pumping or mixing element and related methods |
US8182137B2 (en) | 2000-10-09 | 2012-05-22 | Atmi Packaging, Inc. | Mixing bag or vessel with a fluid-agitating element |
US9339026B2 (en) | 2012-06-14 | 2016-05-17 | Therapeutic Proteins International, LLC | Pneumatically agitated and aerated single-use bioreactor |
US10578098B2 (en) | 2005-07-13 | 2020-03-03 | Baxter International Inc. | Medical fluid delivery device actuated via motive fluid |
US10632433B2 (en) | 2006-05-13 | 2020-04-28 | Pall Life Sciences Belgium Bvba | Disposable bioreactor |
US10711238B2 (en) | 2012-10-02 | 2020-07-14 | Repligen Corporation | Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly |
US20210060311A1 (en) * | 2019-04-18 | 2021-03-04 | Michael Bonnette | Pumpless thrombectomy system |
WO2021170561A1 (en) * | 2020-02-26 | 2021-09-02 | Fresenius Medical Care Deutschland Gmbh | Medical diaphragm pump, and diaphragm pump system |
GB2597469A (en) * | 2020-07-22 | 2022-02-02 | Agilent Technologies Inc | Pressurizing fluid by expanding membrane |
US11478578B2 (en) | 2012-06-08 | 2022-10-25 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
Citations (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2659516A (en) * | 1949-05-25 | 1953-11-17 | William P C Smith | Liquid dispenser |
US3199511A (en) * | 1961-04-26 | 1965-08-10 | Kulick George | Apparatus for precise administration of parenteral fluids |
US3737251A (en) * | 1971-02-08 | 1973-06-05 | Alphamedics Mfg Cop | Peristaltic pump |
US3864060A (en) * | 1973-02-21 | 1975-02-04 | Nasa | Automatic liquid inventory collecting and dispensing unit |
US3949753A (en) * | 1972-11-27 | 1976-04-13 | Rolf Dockhorn | Apparatus for supplying aseptic fluids |
US4041944A (en) * | 1975-07-21 | 1977-08-16 | Rhodes William A | Body fluid transfusion and displacement apparatus and method |
US4098434A (en) * | 1975-06-20 | 1978-07-04 | Owens-Illinois, Inc. | Fluid product dispenser |
US4335835A (en) * | 1978-12-26 | 1982-06-22 | Anatros Corporation | Device for the intravenous or enteric infusion of liquids into the human body at a predetermined constant rate |
US4503012A (en) * | 1983-04-19 | 1985-03-05 | American Monitor Corporation | Reagent dispensing system |
US4772256A (en) * | 1986-11-07 | 1988-09-20 | Lantech, Inc. | Methods and apparatus for autotransfusion of blood |
US4842576A (en) * | 1986-10-15 | 1989-06-27 | Baxter International Inc. | System for generating substantially constant fluid pressure |
US4994022A (en) * | 1989-02-02 | 1991-02-19 | Stryker Corporation | Blood conservation system |
US5085345A (en) * | 1985-04-12 | 1992-02-04 | Wells John R | Hydraulic dispenser |
US5810202A (en) * | 1994-10-20 | 1998-09-22 | Rick R. Wascher, P.C. | Disposable self-dispensing pressurized package for delivery of sterile fluids and solutions |
US6056724A (en) * | 1997-01-06 | 2000-05-02 | Medex | Device for injection of medical liquid |
US6206240B1 (en) * | 1999-03-23 | 2001-03-27 | Now Technologies, Inc. | Liquid chemical dispensing system with pressurization |
US20030144646A1 (en) * | 2000-04-28 | 2003-07-31 | Erik Se | Method and apparatus for collecting and transporting liquid |
US20050063250A1 (en) * | 2003-09-04 | 2005-03-24 | Hubbard John Dana | Disposable mixing system |
US20050224523A1 (en) * | 2004-04-13 | 2005-10-13 | Advanced Technology Materials, Inc. | Liquid dispensing method and system with headspace gas removal |
US7114517B2 (en) * | 2001-11-26 | 2006-10-03 | Sund Wesley E | High purity fluid delivery system |
US7172096B2 (en) * | 2004-11-15 | 2007-02-06 | Advanced Technology Materials, Inc. | Liquid dispensing system |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8206767D0 (en) * | 1982-11-26 | 1982-11-26 | Seroteknik Hb | SET AND DEVICE FOR BATTERY CENTRIFUGAL SEPARATION OF BLOOD |
-
2007
- 2007-02-28 US US11/680,308 patent/US20070201993A1/en not_active Abandoned
- 2007-02-28 WO PCT/US2007/062976 patent/WO2007101248A2/en active Application Filing
Patent Citations (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2659516A (en) * | 1949-05-25 | 1953-11-17 | William P C Smith | Liquid dispenser |
US3199511A (en) * | 1961-04-26 | 1965-08-10 | Kulick George | Apparatus for precise administration of parenteral fluids |
US3737251A (en) * | 1971-02-08 | 1973-06-05 | Alphamedics Mfg Cop | Peristaltic pump |
US3949753A (en) * | 1972-11-27 | 1976-04-13 | Rolf Dockhorn | Apparatus for supplying aseptic fluids |
US3864060A (en) * | 1973-02-21 | 1975-02-04 | Nasa | Automatic liquid inventory collecting and dispensing unit |
US4098434A (en) * | 1975-06-20 | 1978-07-04 | Owens-Illinois, Inc. | Fluid product dispenser |
US4147278A (en) * | 1975-06-20 | 1979-04-03 | Owens-Illinois, Inc. | Fluid product dispenser |
US4041944A (en) * | 1975-07-21 | 1977-08-16 | Rhodes William A | Body fluid transfusion and displacement apparatus and method |
US4335835A (en) * | 1978-12-26 | 1982-06-22 | Anatros Corporation | Device for the intravenous or enteric infusion of liquids into the human body at a predetermined constant rate |
US4503012A (en) * | 1983-04-19 | 1985-03-05 | American Monitor Corporation | Reagent dispensing system |
US5085345A (en) * | 1985-04-12 | 1992-02-04 | Wells John R | Hydraulic dispenser |
US4842576A (en) * | 1986-10-15 | 1989-06-27 | Baxter International Inc. | System for generating substantially constant fluid pressure |
US4772256A (en) * | 1986-11-07 | 1988-09-20 | Lantech, Inc. | Methods and apparatus for autotransfusion of blood |
US4994022A (en) * | 1989-02-02 | 1991-02-19 | Stryker Corporation | Blood conservation system |
US5810202A (en) * | 1994-10-20 | 1998-09-22 | Rick R. Wascher, P.C. | Disposable self-dispensing pressurized package for delivery of sterile fluids and solutions |
US6056724A (en) * | 1997-01-06 | 2000-05-02 | Medex | Device for injection of medical liquid |
US6206240B1 (en) * | 1999-03-23 | 2001-03-27 | Now Technologies, Inc. | Liquid chemical dispensing system with pressurization |
US20030144646A1 (en) * | 2000-04-28 | 2003-07-31 | Erik Se | Method and apparatus for collecting and transporting liquid |
US7114517B2 (en) * | 2001-11-26 | 2006-10-03 | Sund Wesley E | High purity fluid delivery system |
US20050063250A1 (en) * | 2003-09-04 | 2005-03-24 | Hubbard John Dana | Disposable mixing system |
US20050224523A1 (en) * | 2004-04-13 | 2005-10-13 | Advanced Technology Materials, Inc. | Liquid dispensing method and system with headspace gas removal |
US7172096B2 (en) * | 2004-11-15 | 2007-02-06 | Advanced Technology Materials, Inc. | Liquid dispensing system |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090129201A1 (en) * | 2000-10-09 | 2009-05-21 | Terentiev Alexandre N | Mixing Bag or Vessel Having a Fluid-Agitating Element |
US8282269B2 (en) | 2000-10-09 | 2012-10-09 | Atmi Packaging, Inc. | Mixing bag or vessel having a fluid-agitating element |
US8182137B2 (en) | 2000-10-09 | 2012-05-22 | Atmi Packaging, Inc. | Mixing bag or vessel with a fluid-agitating element |
US20100290308A1 (en) * | 2000-10-09 | 2010-11-18 | Terentiev Alexandre N | Systems using a levitating, rotating pumping or mixing element and related methods |
US8123199B2 (en) | 2004-01-07 | 2012-02-28 | Atmi Packaging, Inc. | Bioreactor |
US20100197003A1 (en) * | 2004-01-07 | 2010-08-05 | Terentiev Alexandre N | Bioreactor |
US10578098B2 (en) | 2005-07-13 | 2020-03-03 | Baxter International Inc. | Medical fluid delivery device actuated via motive fluid |
US11384748B2 (en) | 2005-07-13 | 2022-07-12 | Baxter International Inc. | Blood treatment system having pulsatile blood intake |
US10590924B2 (en) | 2005-07-13 | 2020-03-17 | Baxter International Inc. | Medical fluid pumping system including pump and machine chassis mounting regime |
US10670005B2 (en) | 2005-07-13 | 2020-06-02 | Baxter International Inc. | Diaphragm pumps and pumping systems |
US20090219780A1 (en) * | 2005-10-04 | 2009-09-03 | Jose Castillo | Mixing System Including a Flexible Bag, Specific Flexible Bag and Locating System for the Mixing System |
US20090130757A1 (en) * | 2005-10-26 | 2009-05-21 | Terentiev Alexandre N | Bioreactor with mixer and sparger |
US10632433B2 (en) | 2006-05-13 | 2020-04-28 | Pall Life Sciences Belgium Bvba | Disposable bioreactor |
US8282267B2 (en) | 2006-10-03 | 2012-10-09 | Artelis S.A. | Mixing system including a flexible bag, specific flexible bag and locating system for the mixing system |
US8292491B2 (en) | 2006-10-03 | 2012-10-23 | Artelis S.A. | Flexible bag, mixing system and method for fixing a flexible bag inside a rigid container |
US20100215290A1 (en) * | 2006-10-03 | 2010-08-26 | Jose Castillo | Flexible Bag, Mixing System and Method for Fixing a Flexible Bag Inside a Rigid Container |
US11478578B2 (en) | 2012-06-08 | 2022-10-25 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
US9339026B2 (en) | 2012-06-14 | 2016-05-17 | Therapeutic Proteins International, LLC | Pneumatically agitated and aerated single-use bioreactor |
US10711238B2 (en) | 2012-10-02 | 2020-07-14 | Repligen Corporation | Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly |
US11555174B2 (en) | 2012-10-02 | 2023-01-17 | Repligen Corporation | Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly |
US20210060311A1 (en) * | 2019-04-18 | 2021-03-04 | Michael Bonnette | Pumpless thrombectomy system |
US11602617B2 (en) * | 2019-04-18 | 2023-03-14 | Michael Bonnette | Pumpless thrombectomy system |
WO2021170561A1 (en) * | 2020-02-26 | 2021-09-02 | Fresenius Medical Care Deutschland Gmbh | Medical diaphragm pump, and diaphragm pump system |
GB2597469A (en) * | 2020-07-22 | 2022-02-02 | Agilent Technologies Inc | Pressurizing fluid by expanding membrane |
Also Published As
Publication number | Publication date |
---|---|
WO2007101248A3 (en) | 2008-03-20 |
WO2007101248A2 (en) | 2007-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20070201993A1 (en) | Disposable pumping apparatus based on flexible vessels in pressurized containers | |
CN108368839B (en) | Disposable alternating tangential flow filtration unit | |
KR102475193B1 (en) | Plunger pumping device for hollow fiber filters | |
EP0689391B1 (en) | Method and device in high-pressure treatment of liquid substances | |
US11865478B2 (en) | Dual pumping arrangement for a hollow fiber filter | |
US20070175538A1 (en) | System and method for filling containers with liquid under varying pressure conditions | |
WO2014051503A1 (en) | Tangential flow perfusion system | |
EP2268338B1 (en) | Blood treatment apparatus | |
CN107614080B (en) | Degasification, de-soak and damping unit | |
US7972058B2 (en) | Apparatus and method for mixing with a diaphragm pump | |
CN110877770A (en) | Double-layer disposable liquid storage bag and constant-pressure conveying device thereof | |
JP2010203432A (en) | System and pump apparatus for processing fluid sample | |
AU2013364534B2 (en) | Filter device and method of cleaning a filter element | |
CN211767424U (en) | Double-layer disposable liquid storage bag and constant-pressure conveying device thereof | |
US20240091774A1 (en) | Passive pressure wave dampener systems | |
US20230332593A1 (en) | Expandable, inner liner pump | |
CN211005322U (en) | CAR-T cell sorting activation device and CAR-T product preparation system | |
EP4339459A1 (en) | Passive pressure wave dampener systems | |
JP2011200312A (en) | Operation method of hemodialyzer, and hemodialyzer | |
CN115786111A (en) | Alternate tangential flow filtration device and perfusion culture system | |
JPH04358800A (en) | Liquid feeding pump |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: LEVTECH, INC., KENTUCKY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TERENTIEV, ALEXANDRE N.;TERENTYEV, SERGEY;REEL/FRAME:019333/0576 Effective date: 20060306 |
|
AS | Assignment |
Owner name: ATMI PACKAGING, INC., CONNECTICUT Free format text: MERGER;ASSIGNOR:LEVTECH, INC.;REEL/FRAME:025767/0332 Effective date: 20101221 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |