US20080221440A1 - Imaging and tools for use with moving organs - Google Patents
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- US20080221440A1 US20080221440A1 US12/075,252 US7525208A US2008221440A1 US 20080221440 A1 US20080221440 A1 US 20080221440A1 US 7525208 A US7525208 A US 7525208A US 2008221440 A1 US2008221440 A1 US 2008221440A1
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Definitions
- the present invention generally relates to medical apparatus. Specifically, the present invention relates to stabilizing imaging of cyclically moving body portions and synchronizing the actuation and/or movement of tools with the cyclical motion of cyclically moving body portions.
- Continuous images of a cyclically-moving body organ are typically displayed in the course of many medical procedures such as procedures performed on the heart, the thorax, the respiratory tract, the eyes, or the cardiovascular system. Such images typically shift constantly and are also prone to blurring. Consequently, such images are typically difficult to observe, and are difficult to use in making clinical decisions over an extended period of time (such as the entire duration of the procedure).
- U.S. Pat. No. 4,865,043 to Shimoni which is incorporated herein by reference, describes a data selection method and system using a plurality of multi-dimensional windows wherein two parameters of ECG signals are tested for determining whether the imaging data received simultaneously with the ECG signal is to be accepted.
- the plurality of windows are described as providing a capability to gate and to sort imaging data based on the passage of associated ECG signals through each of the plurality of windows with different parameters.
- images are described as being reconstructed for a population of abnormally short or long heart cycles from a common data pool.
- U.S. Pat. No. 4,382,184 to Wernikoff which is incorporated herein by reference, describes X-ray apparatus and methods for producing discrete images of a human organ in fluctuating motion, e.g., the heart and related vessels. Each image is derived at a selected time related to the cardiac cycle. The images are independently presented on respective discrete areas within a common image plane.
- a source of X-rays irradiates the organ.
- a physiological synchronizer produces timing signals within the cardiac cycle for controlling the periods of transmission of the X-ray beam through the organ during, for example, end diastole and end systole.
- An anti-scattering, masking frame has alternate parallel slits and bars at equal intervals exposing substantially half the area of presentation of an X-ray sensitive film in alternate, equally spaced area strips during, e.g., diastole.
- the frame is repositioned in response to a signal from the synchronizer for actuating it relative to the film, such that the bars then cover the sensitized areas of the film and expose substantially the remaining half of the film during systole.
- the image elements are interdigitally juxtaposed to present the diastolic and systolic images in an interlaced pattern. Relative displacements of the organ during a cardiac cycle may be determined from the juxtaposed image elements.
- U.S. Pat. No. 4,016,871 to Schiff which is incorporated herein by reference, describes a system which is capable of simultaneously displaying a plurality of waveforms on the face of a CRT which are representative of ECG, arterial pressures and operating states of the mechanical heart assistance devices, as well as a “timing bar” which sweeps across the CRT face in synchronism with the ECG trace, for example.
- Optical pickups are slidably mounted adjacent the CRT face across the path of the “timing bar” sweep for activating photodetectors which in turn initiate inflation and deflation of mechanical assistive devices at any desired point along the ECG or pressure trace.
- any one of the pressure or ECG traces may be “frozen” on the display face to facilitate comparison between a trace of the condition of the heart prior to the use of heart assistance and a trace of the augmented condition. All traces may be freely moved to any location upon the display face so as to permit close positioning and even superimposition of two or more traces to still further facilitate visual comparisons.
- the timing bar may also be utilized to provide an electrical pacing assist for controlling patient heart rate as well as for extending the heart refractory period enabling the assistance devices to operate at reduced rates.
- U.S. Pat. No. 4,031,884 to Henzel which is incorporated herein by reference, describes apparatus for correlating the respiratory and cardiac cycles includes a circuit for defining a chosen period in the progress of the respiratory cycle as the end of a regulatable delay beginning when the ascending front of the inspiratorial pressure reaches a regulatable level as well as a circuit for defining a chosen period in the progress of the cardiac cycle as the end of a regulatable delay beginning when the differential dV/dt of the blood pressure reaches a regulatable level.
- An operator such as a terminal relay is activated upon the coincidence of these two periods in time after a regulatable delay and during a regulatable period.
- U.S. Pat. No. 4,878,115 to Elion which is incorporated herein by reference, describes a method in which a dynamic coronary roadmap of the coronary artery system is produced by recording and storing a visual image of the heart creating a mask sequence, recording and storing another dynamic visual image of the heart after injection of a contrast medium thereby creating a contrast sequence, matching the different durations of two sequences and subtracting the contrast sequence from the mask sequence producing a roadmap sequence.
- the roadmap sequence is then replayed and added to live fluoroscopic images of the beating heart. Replay of the roadmap sequence is triggered by receipt of an ECG R-wave.
- the result is described as a dynamically moving coronary roadmap image which moves in precise synchronization with the live incoming fluoroscopic image of the beating heart.
- U.S. Pat. No. 4,709,385 to Pfeiler which is incorporated herein by reference, describes an x-ray diagnostics installation for subtraction angiography, which has an image memory connected to an output of an x-ray image intensifier video chain which has a number of addresses for storing individual x-ray video signals obtained during a dynamic body cycle of a patient under observation.
- a differencing unit receives stored signals from the image memory as well as current video signals and subtracts those signals to form a superimposed image. Entry and readout of signals to and from the image memory is under the command of a control unit which is connected to the patient through, for example, an EKG circuit for identifying selected occurrences in the body cycle under observation. Entry and readout of data from the image memory is thereby controlled in synchronization with the selected occurrences in the cycle.
- U.S. Pat. No. 4,270,143 to Morris which is incorporated herein by reference, describes a cross-correlation video tracker and method for automatically tracking a relatively moving scene by storing elements from a frame of a video signal to establish a reference frame and comparing elements from a subsequent frame with the stored reference frame to derive signals indicating the direction and angular distance of scene relative movement.
- a cross-correlation difference signal is generated which represents the difference between a pair of cross-correlation signals dependent on the correlations of the subsequent frame elements and the stored reference elements at two predetermined opposite relative shifts.
- a circuit is responsive to this difference signal for generating an error signal indicative of the amount of shift required to center the stored reference frame with respect to the subsequent frame.
- U.S. Pat. No. 6,937,696 to Mostafavi which is incorporated herein by reference, describes a method and system for physiological gating.
- a method and system for detecting and estimating regular cycles of physiological activity or movements is also disclosed.
- Another disclosed embodiment is directed to predictive actuation of gating system components.
- Yet another disclosed embodiment is directed to physiological gating of radiation treatment based upon the phase of the physiological activity. Gating can be performed, either prospectively or retrospectively, to any type of procedure, including radiation therapy or imaging, or to other types of medical devices and procedures such as PET, MRI, SPECT, and CT scans.
- U.S. Pat. No. 6,246,898 to Vesely et al. which is incorporated herein by reference, describes a method for carrying out a medical procedure using a 3-D tracking and imaging system.
- a surgical instrument such as a catheter, probe, sensor, pacemaker lead, needle, or the like is inserted into a living being, and the position of the surgical instrument is tracked as it moves through a medium in a bodily structure. The location of the surgical instrument relative to its immediate surroundings is displayed to improve a physician's ability to precisely position the surgical instrument.
- the medical procedures including targeted drug delivery, sewing sutures, removal of an obstruction from the circulatory system, a biopsy, amniocentesis, brain surgery, measurement of cervical dilation, evaluation of knee stability, assessment of myocardial contractibility, eye surgery, prostate surgery, trans-myocardial revascularization (TMR), robotic surgery, and evaluation of RF transmissions.
- TMR trans-myocardial revascularization
- U.S. Pat. No. 6,666,863 to Wentzel et al. which is incorporated herein by reference, describes devices and methods for performing percutaneous myocardial revascularization (PMR).
- PMR percutaneous myocardial revascularization
- An embodiment is described in which a detector of an ablation controller provides a detect signal when a sensor block output signal indicates that a first electrode is touching the wall of the heart.
- the ablation controller may also provide a detect signal when the heart is in a less vulnerable portion of the cardiac rhythm, such as when the ventricles of the heart are contracting.
- the ablation controller is described as helping to identify when the first electrode is in contact with the wall of the heart, thereby reducing the likelihood that an ablation will be triggered when the first electrode is not in contact with the endocardium of the heart and cause damage to the blood platelets within the heart.
- U.S. Pat. No. 5,176,619 to Segalowitz which is incorporated herein by reference, describes a heart-assist device which includes a flexible catheter carrying at least a ventricular balloon, such balloon corresponding in size and shape to the size and shape of the left ventricle in the heart being assisted, the ventricular balloon being progressively inflated creating a wave-like pushing effect and deflated synchronously and automatically by means of a control console which responds to heart signals from the catheter or elsewhere.
- ablation catheter that has an ablation electrode at a distal end coupled to an ablation power source through a low impedance coupling.
- ablation only occurs while the heart is in a desired part of the cardiac cycle, the ablation power intervals being triggered by timing pulses synchronized with detection of the R wave. This mode of actuation is described as assuring that the heart is essentially stationary before delivery of ablation energy, thus minimizing the risk of inadvertently ablating healthy tissue.
- Timinger et al. entitled “Motion compensated coronary interventional navigation by means of diaphragm tracking and elastic motion models” (Phys Med Biol. 2005 Feb. 7; 50(3):491-503), which is incorporated herein by reference, presents a method for compensating the location of an interventional device measured by a magnetic tracking system for organ motion and thus registering it dynamically to a 3D virtual roadmap.
- the motion compensation is accomplished by using an elastic motion model which is driven by the ECG signal and a respiratory sensor signal derived from ultrasonic diaphragm tracking.
- Timinger et al. entitled “Motion compensation for interventional navigation on 3D static roadmaps based on an affine model and gating” (Phys Med Biol. 2004 Mar. 7; 49(5):719-32), which is incorporated herein by reference, describes a method for enabling cardiac interventional navigation on motion-compensated 3D static roadmaps.
- An arterial roadmap for the subsequent manipulation of catheters under fluoroscopy is generated by means of first injecting a contrast agent into said arteries and using the resulting, “highlighted” arterial image as a background to the real-time fluoroscopic imaging of the catheterization procedure.
- apparatus and methods are used for facilitating medical procedures performed on cyclically-moving organs, so that such procedures are performed under a partial or full virtual stabilization of such organs.
- the stabilization comprises at least one of the following elements: the stabilization of image(s) being viewed with respect to the motion of an organ, and the actuation of tool(s) applied to the organ in synchronization with the organ's motion.
- continuously-generated image frames of cyclically-moving organs are gated to one or more physiological signals or processes, wherein the cycle(s) of such signals or processes correspond to a motion cycle of the organ being imaged. Consequently, the displayed gated image frames of the organ are typically all in a selected same phase of a motion cycle of the organ.
- the gated images are displayed with a smoothened transition filling the gaps among them, generating a synthesized, continuous video stream.
- image tracking is applied to continuously-generated images of moving organs, to align such images to one another.
- the motion to which such tracking is applied may be cyclical, or non-cyclical, or a combination of both.
- the visual effect of such motion is typically reduced by the image tracking.
- a combination of the aforementioned gating, tracking and/or gap filling are applied to generate a stabilized image stream.
- road mapping is applied to the stabilized image stream.
- roadmapping is applied to the stabilized image stream to facilitate a medical procedure that is performed on the moving organ.
- the actuation or movement of one or more medical tools applied to a cyclically-moving organ is synchronized with one or more physiological signals or processes whose cycle(s) corresponds to a motion cycle of the organ. Consequently, the tool is typically actuated only during one or more selected same phases in a motion cycle of the organ.
- the synchronized actuation of medical tools controls the application of linear motion, angular motion, energy, substance delivery, or any combination thereof.
- the aforementioned stabilized imaging and synchronized tool application are applied jointly to a cyclically moving organ.
- images of the organ are stabilized with respect to a given phase of the cycle, and the actuation of the tool is synchronized to the same phase. In some embodiments, this leads to virtual stabilization of the cyclically-moving organ, both with respect to the imaging of the organ and the tools being moved and/or applied.
- the scope of the present invention includes synchronized tool application and/or movement with respect to a cyclically moving organ, using techniques described herein, even in the absence of stabilized imaging as described herein, or even in the absence of any imaging.
- the aforementioned techniques are applied to an organ that may not be cyclically moving, but is cyclically active, for example, an organ that undergoes neural cyclic activity.
- apparatus for imaging a portion of a body of a subject that moves as a result of cyclic activity of a first body system of the subject and that also undergoes additional motion including:
- an imaging device for acquiring a plurality of image frames of the portion of the subject's body
- control unit configured to generate a stabilized set of image frames of the portion of the subject's body:
- a display configured to display the stabilized set of image frames of the portion of the subject's body.
- control unit is configured to identify the given phase of the cyclic activity using a gating signal, and the display is configured to display a representation of the gating signal simultaneously with displaying the stabilized set of image frames.
- the display is configured to display an enlarged stabilized set of image frames of a region within the portion of the subject's body.
- control unit to generate the stabilized set of image frames of the portion of the subject's body, the control unit is configured:
- control unit to generate the stabilized set of image frames of the portion of the subject's body, the control unit is configured:
- control unit to generate the stabilized set of image frames of the portion of the subject's body, the control unit is configured:
- control unit to generate the stabilized set of image frames of the portion of the subject's body, the control unit is configured:
- control unit includes a video tracker selected from the group consisting of: an edge tracker, a centroid tracker, a correlation tracker, and an object tracker, and the control unit is configured to image track the at least the set of image frames using the selected video tracker.
- control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase by controlling the imaging device to acquire the plurality of image frames only when the cyclic activity is at the given phase.
- the imaging device is configured to acquire the plurality of image frames throughout the cyclic activity
- control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase, by selecting image frames corresponding to image frames of the portion acquired during the given phase from the plurality of image frames.
- the apparatus further includes a user interface
- the control unit is configured to receive an input from a user, via the user interface, and to select a phase of the cyclic activity as being the given phase in response to the input.
- the display is configured to display the plurality of acquired image frames simultaneously with displaying the stabilized set of image frames.
- the apparatus is configured for the display to display the stabilized set of image frames in real time with respect to the acquisition of the plurality of image frames by the imaging device.
- the apparatus is configured for the display to display the stabilized set of image frames within 4 seconds of the imaging device having imaged the plurality of image frames.
- the apparatus is configured for the display to display the stabilized set of image frames less than two cycles of the cyclic activity after the imaging device imaged the plurality of image frames.
- the apparatus is configured for the display to display the stabilized set of image frames during a medical procedure during which the imaging device images the plurality of image frames.
- the apparatus is configured to display the stabilized set of image frames subsequent to a medical procedure during which the imaging device imaged the plurality of image frames.
- the apparatus further includes a data storage unit configured to store the stabilized set of image frames.
- control unit is configured to enhance the stabilized set of image frames by image processing the stabilized set of image frames.
- the additional motion is not associated with cyclic activity of the subject's body
- the control unit is configured to reduce the imaged motion associated with the additional motion that is not associated with cyclic activity, by image tracking at least the set of image frames.
- the additional motion is associated with whole-body motion of the subject
- the control unit is configured to reduce the imaged motion associated with the whole-body motion by image tracking at least the set of image frames.
- the apparatus further includes:
- an injection tool configured to inject the contrast agent into a space within the portion of the subject's body
- the imaging device is configured to acquire a first image frame of the space during the given phase of a first cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the space,
- the imaging device is configured to acquire a second image frame of the space during the given phase of a second cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the space, and
- the display is configured to display the first and the second image frame of the space overlaid on at least one same frame of the stabilized set of image frames.
- the space includes a lumen containing an occlusion
- the injection tool is configured to inject the contrast agent into the lumen on a proximal side of the occlusion and on a distal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the proximal side of the occlusion during the given phase of a cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the proximal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the distal side of the occlusion during the given phase of the cycle, at a time when at least some of the contrast agent is present within the lumen on the distal side of the occlusion, and
- the display is configured to display the at least one image frame of the lumen on the proximal side of the occlusion and the at least one image frame of the lumen on the distal side of the occlusion overlaid on at least one same frame of the stabilized set of image frames.
- the space includes a lumen containing an occlusion
- the injection tool is configured to inject the contrast agent into the lumen on a proximal side of the occlusion and on a distal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the proximal side of the occlusion during the given phase of a first cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the proximal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the distal side of the occlusion during the given phase of a second cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the distal side of the occlusion, and
- the display is configured to display the at least one image frame of the lumen on the proximal side of the occlusion and the at least one image frame of the lumen on the distal side of the occlusion overlaid on at least one same frame of the stabilized set of image frames.
- the space includes a lumen containing an occlusion
- the injection tool is configured to inject the contrast agent into the lumen on a proximal side of the occlusion
- the apparatus further includes a second injection tool configured to inject the contrast agent into the lumen on a distal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the proximal side of the occlusion during the given phase of a cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the proximal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the distal side of the occlusion during the given phase of the cycle, at a time when at least some of the contrast agent is present within the lumen on the distal side of the occlusion, and
- the display is configured to display the at least one image frame of the lumen on the proximal side of the occlusion and the at least one image frame of the lumen on the distal side of the occlusion overlaid on at least one same frame of the stabilized set of image frames.
- the space includes a lumen containing an occlusion
- the injection tool is configured to inject the contrast agent into the lumen on a proximal side of the occlusion
- the apparatus further includes a second injection tool configured to inject the contrast agent into the lumen on a distal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the proximal side of the occlusion during the given phase of a first cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the proximal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the distal side of the occlusion during the given phase of a second cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the distal side of the occlusion, and
- the display is configured to display the at least one image frame of the lumen on the proximal side of the occlusion and the at least one image frame of the lumen on the distal side of the occlusion overlaid on at least one same frame of the stabilized set of image frames.
- the imaging device includes a fluoroscope.
- the space includes a space selected from the group consisting of a chamber of a heart of the subject, a lumen of a coronary blood vessel of the subject, and a lumen of an aorta of the subject, and the injection tool is configured to inject the contrast agent into the selected space.
- control unit is configured to construct at least one three-dimensional image frame of the space, during the given phase, based on image frames acquired at the time when at least some of the contrast agent is present within the space.
- the apparatus further includes a medical tool configured to be inserted into the space, the apparatus is configured to acquire an image of the tool while the tool is inside the space, and the display is configured to display the image of the tool overlaid on the image frame of the space.
- control unit is configured to identify when the injection tool injects the contrast agent by image processing a set of image frames of the space.
- control unit is configured to identify when the injection tool injects the contrast agent by specifically analyzing a region of at least some of the plurality of image frames that corresponds to a vicinity of a distal tip of the injection tool.
- control unit is configured to identify when the injection tool injects the contrast agent by determining a level of darkness of the region of at least some of the plurality of image frames that corresponds to the vicinity of the distal tip of the injection tool.
- the apparatus further includes a user interface, and the display is configured to receive an input from a user, via the user interface, and to display a marking at a given position within the portion of the subject's body within the stabilized set of image frames, in response to the input.
- the display is configured to display two or more views of the stabilized set of image frames of the portion of the subject's body, and to display the marking at the given position within respective views of the stabilized set of image frames.
- the imaging device is further configured to image a plurality of images of a medical tool disposed within the portion of the subject's body, and the control unit is configured to generate a stabilized set of image frames of the medical tool.
- the medical tool includes a medical tool that is implanted within the portion of the subject's body, and the imaging device is configured to image a plurality of images of the implanted medical tool.
- the medical tool includes a medical tool that is transiently inserted within the portion of the subject's body, and the imaging device is configured to image a plurality of images of the medical tool while it is inserted within the portion.
- control unit is configured to enhance the stabilized set of image frames of the medical tool by image processing the stabilized set of image frames of the medical tool.
- control unit is configured to determine a physiological parameter of the subject by analyzing the stabilized set of image frames.
- control unit is configured to determine a parameter relating to cardiac function of the subject by analyzing the stabilized set of image frames.
- control unit is configured to determine a parameter relating to respiratory function of the subject by analyzing the stabilized set of image frames.
- control unit in generating the stabilized set of image frames, is configured to smoothen a transition between successive frames of the set of frames.
- control unit is configured to smoothen the transition between the successive frames, by:
- control unit is configured to smoothen the transition between the successive frames, by:
- control unit is configured to determine a dimension of a region within the portion of the subject's body, by analyzing the stabilized set of image frames.
- control unit is configured to output an indication of a size of a medical tool relative to the region within the portion of the subject's body.
- the apparatus further includes a medical tool configured to be inserted into the portion of the subject's body and having a known dimension
- the control unit is configured to determine the dimension of the region by comparing a dimension of the tool within the stabilized set of image frames to the known dimension.
- the medical tool includes markers, the markers being separated from each other by a known distance
- the control unit is configured to determine an orientation at which the medical tool is disposed within the portion of the subject's body by determining a distance between the markers as viewed within the stabilized set of image frames with respect to the known distance.
- control unit is configured to generate a simulated image of a virtual medical tool disposed at the orientation within the stabilized set of image frames of the portion of the subject's body, in response to the determining of the distance.
- the apparatus further includes a user interface
- the control unit is configured to receive an input from a user, via the user interface, and to generate a simulated image of a virtual medical tool disposed within the stabilized set of image frames of the portion of the subject's body, in response to receiving the input.
- control unit is configured to output dimensions of a real medical tool that corresponds to the simulated image of the virtual medical tool.
- control unit is configured to output the dimensions of the real medical tool by accounting for an orientation at which the virtual medical tool is disposed within the simulated image.
- control unit is configured to output the dimensions of the real medical tool by accounting for a curvature of a region of the portion of the subject's body within which region the virtual medical tool is disposed within the simulated image.
- control unit is configured to receive a first and a second input from the user and to generate respective simulated images of first and second medical tools being placed within the stabilized set of image frames of the portion of the subject's body, in response to receiving the inputs.
- the imaging device includes two or more imaging devices
- the control unit is configured to generate two or more stabilized sets of image frames of the portion of the subject's body, the sets of image frames having been imaged by respective imaging devices of the two or more imaging devices.
- a first imaging device of the two or more imaging devices is configured to image the portion of the subject's body before a medical procedure
- a second imaging device of the two or more imaging devices is configured to image the portion of the subject's body during the medical procedure
- the control unit is configured to generate the stabilized sets of image frames during the medical procedure.
- a first imaging device of the two or more imaging devices is configured to image the portion of the subject's body from outside the portion of the subject's body
- a second imaging device of the two or more imaging devices is configured to image regions within the portion of the subject's body while the second imaging device is disposed at respective locations within the portion of the subject's body.
- control unit is configured to associate (a) locations within the stabilized image frames acquired by the first imaging device that correspond to the respective locations of the second imaging device, with (b) respective image frames acquired by the second imaging device while the second imaging device was disposed at the respective locations.
- the apparatus further includes a medical tool configured to be inserted into the portion of the subject's body to a vicinity of the respective locations while the second imaging device is not disposed at the respective locations, and the control unit is configured to generate (a) respective image frames acquired by the second imaging device while the second imaging device was disposed at the respective locations, when (b) the medical tool is disposed in a vicinity of the respective locations.
- the first imaging device includes a fluoroscope and the second imaging device includes an intravascular ultrasound probe.
- the first imaging device includes a CT scanner and the second imaging device includes an intravascular ultrasound probe.
- the first imaging device is configured to acquire the plurality of image frames before the second imaging device images the regions within the portion of the subject's body.
- the first imaging device is configured to acquire the plurality of image frames while the second imaging device images the regions within the portion of the subject's body, and the first imaging device is configured to acquire the plurality of image frames by acquiring a plurality of image frames of the second imaging device disposed within the portion.
- the stabilized set of image frames defines a first stabilized set of image frames
- control unit is configured to generate an additional stabilized set of image frames of the portion of the subject's body
- the given phase includes a systolic phase of a cardiac cycle of the subject and the further given phase includes a diastolic phase of the subject's cardiac cycle
- the control unit is configured to generate sets of image frames which are stabilized respectively to the systolic and to the diastolic phases of the subject's cardiac cycle.
- the apparatus further includes a user interface
- the control unit is configured to receive an input from a user, via the user interface, and to generate simulated images of a virtual medical tool disposed within the stabilized sets of image frames of the portion of the subject's body at the given phase and at the further given phase, in response to receiving the input.
- the apparatus further includes a medical tool disposed within the portion of the subject's body, and the control unit is configured to generate stabilized images of the medical tool disposed within the portion of the subject's body respectively at the given phase and at the further given phase.
- control unit is configured to determine a physiological parameter of the subject by comparing the additional stabilized set of image frames to the first stabilized set of image frames.
- control unit is configured to determine a parameter relating to cardiac function of the subject by comparing the additional stabilized set of image frames to the first stabilized set of image frames.
- control unit is configured to determine a parameter relating to respiratory function of the subject by comparing the additional stabilized set of image frames to the first stabilized set of image frames.
- the cyclic activity includes a cardiac cycle of the subject
- the sensor includes a sensor for sensing a phase of the subject's cardiac cycle.
- the given phase includes an end-diastolic phase of the subject's cardiac cycle
- the control unit is configured to generate a stabilized set of the image frames corresponding to image frames of the portion acquired during the end-diastolic phase of the subject's cardiac cycle.
- the senor includes a blood pressure sensor.
- the senor includes an ECG sensor.
- the senor includes an image processor configured to sense a phase of the subject's cardiac cycle by comparing image frames of the plurality of image frames to at least one of the image frames of the plurality of image frames.
- the cyclic activity includes a respiratory cycle of the subject
- the sensor includes a sensor for sensing a phase of the subject's respiratory cycle.
- the senor includes an image processor configured to sense a phase of the subject's respiratory cycle by comparing image frames of the plurality of image frames to at least one of the image frames of the plurality of image frames.
- the additional motion is a result of cyclic activity of a second body system of the subject
- the control unit is configured to reduce imaged motion of the portion of the subject's body associated with the cyclic activity of the second body system by image tracking at least the set of image frames.
- the cyclic activity of the first body system has a greater frequency than the cyclic activity of the second body system
- control unit is configured to generate the stabilized set of image frames of the portion of the subject's body:
- the cyclic activity of the first body system has a lower frequency than a frequency of the cyclic activity of the second body system
- control unit is configured to generate the stabilized set of image frames of the portion of the subject's body:
- the cyclic activity of the first body system includes a cardiac cycle of the subject
- the cyclic activity of the second body system includes a respiratory cycle of the subject
- control unit is configured to generate the stabilized set of image frames of the portion of the subject's body:
- the cyclic activity of the first body system includes a respiratory cycle of the subject
- the cyclic activity of the second body system includes a cardiac cycle of the subject
- control unit is configured to generate the stabilized set of image frames of the portion of the subject's body:
- apparatus for imaging a portion of a body of a subject that moves as a result of cyclic activity of a first body system of the subject and that also undergoes additional motion, and for use with an imaging device for acquiring a plurality of image frames of the portion of the subject's body, a sensor for sensing a phase of the cyclic activity of the first body system, and a display configured to display image frames of the portion of the subject's body, the apparatus including:
- control unit configured to generate a stabilized set of image frames of the portion of the subject's body:
- control unit is configured to output the stabilized set of image frames to be displayed on the display.
- apparatus for imaging a portion of a body of a subject that moves as a result of cardiac cyclic activity of the subject and that also undergoes additional motion that is at least partially a result of a respiratory cycle of the subject including:
- an imaging device for acquiring a plurality of image frames of the portion of the subject's body
- control unit configured to generate a stabilized set of image frames of the portion of the subject's body:
- a display configured to display the stabilized set of image frames of the portion of the subject's body.
- apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- a medical tool configured to perform a function with respect to the portion of the subject's body
- control unit configured:
- control unit is configured to move a center of the tool by moving the portion of the tool in the given direction.
- the tool includes a tool configured to be controlled remotely by a user.
- control unit is configured to be reversibly coupled to the tool.
- control unit is integrated into the tool.
- the tool includes a guidewire configured to be moved within the portion of the subject's body.
- the tool is configured to penetrate an occlusion of a lumen of the portion of the subject's body by being advanced through the lumen.
- the tool includes a valve configured to be implanted within the portion of the subject's body by being expanded within the portion, and the control unit is configured to move at least a portion of the valve in the given direction, by moving the at least the portion of the valve in an expansion-related direction.
- the tool includes a septal-closure device configured to be implanted within the portion of the subject's body by being expanded within the portion, and the control unit is configured to move at least a portion of the septal-closure device in the given direction, by moving the at least the portion of the septal-closure device in an expansion-related direction.
- the cyclic activity includes a respiratory cycle of the subject, and the sensor is configured to sense a phase of the respiratory cycle.
- the senor includes an image processor configured to sense a phase of the subject's respiratory cycle by comparing image frames of a plurality of image frames of the portion of the subject's body to at least one of the image frames of the plurality of image frames.
- the cyclic activity includes a cardiac cycle of the subject, and the sensor is configured to sense a phase of the cardiac cycle.
- the senor includes a blood pressure sensor.
- the senor includes an image processor configured to sense a phase of the subject's cardiac cycle, by comparing image frames of the plurality of image frames to at least one of the image frames of the plurality of image frames.
- the senor includes an ECG sensor configured to sense a phase of the cardiac cycle by detecting an ECG signal of the subject.
- the tool includes a balloon configured to be inflated inside a lumen of the portion of the subject's body, and the control unit is configured to move at least a portion of the balloon in the given direction, by moving a surface of the balloon in an inflation-related direction.
- control unit is configured to inflate the balloon continuously for a period of time prior to the first cycle of the cyclic activity.
- control unit is configured to inflate the balloon continuously for a period of time subsequent to the second cycle of the cyclic activity.
- the apparatus further includes a stent, and the stent is configured to be positioned against a wall of the lumen via the inflation of the balloon.
- the apparatus further includes a valve disposed on the surface of the balloon, and the valve is configured to be expanded via the inflation of the balloon.
- the apparatus further includes a valve configured to control flow to the balloon, and the control unit is configured to regulate movement of the surface of the balloon in the inflation-related direction by controlling the valve.
- the apparatus further includes a tube configured to supply fluid to the balloon, the apparatus further includes one or more squeezing surfaces that are disposed around the tube, and the control unit is configured to inhibit movement of the surface of the balloon in the inflation-related direction by driving a current that causes the squeezing surfaces to squeeze together.
- the cyclic activity includes a cardiac cycle of the subject
- the portion of the subject's body includes a portion of a cardiovascular system of the subject that moves as a result of the subject's cardiac cycle
- the balloon is configured to be inflated inside the portion of the cardiovascular system.
- the given phase of the cardiac cycle includes end-diastole
- the control unit is configured to move the surface of the balloon in the inflation-related direction in response to the sensor sensing end-diastole.
- the apparatus further includes an instrument configured to be operated by a user, and the control unit is configured to move the portion of the tool in the given direction, (a) in response to the sensor sensing that the cyclic activity is at the given phase thereof, and (b) in response to the instrument being operated by the user.
- the instrument is configured to provide force feedback to the user that is independent of the cyclic activity.
- the instrument is configured to provide force feedback to the user that is smoothened with respect to the cyclic activity.
- the tool includes a tubular structure configured to bypass an occlusion of a blood vessel within the portion of the subject's body.
- the tubular structure includes a blood vessel graft.
- control unit is configured to move the tubular structure in the given direction by moving a distal end of the structure in a direction from (a) within the blood vessel on a proximal side of the occlusion, to (b) outside the blood vessel.
- control unit is configured to move the tubular structure in the given direction by moving a distal end of the structure in a direction from (a) outside the blood vessel, to (b) within the blood vessel on a distal side of the occlusion.
- apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- a medical tool configured to mechanically perform an action during a single cycle of the cyclic activity with respect to the portion of the subject's body
- control unit configured to actuate the tool to mechanically perform the action in response to the sensor sensing that the cyclic activity is at a given phase thereof.
- the tool includes a balloon configured to apposition itself to a lumen of the portion of the subject's body during the single cycle by being inflated in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- the balloon is configured to be inflated continuously for a period of time prior to the balloon appositioning itself to the lumen by being inflated during the single cycle.
- the balloon is configured to be inflated continuously for a period of time subsequent to the balloon appositioning itself to the lumen by being inflated during the single cycle.
- the tool includes a stent configured to apposition itself to a lumen of the portion of the subject's body by being expanded inside the lumen of the portion of the subject's body during a single cycle of the cyclic activity, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- the stent includes a self-expansible portion configured to self-expand inside the lumen of the portion of the subject's body.
- the tool includes a valve configured to be implanted within the portion of the subject's body by mechanically expanding within the portion, and the control unit is configured to actuate the valve to expand in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- the cyclic activity includes a cardiac cycle of the subject, and the control unit is configured to actuate the valve to expand in response to the sensor sensing that the cardiac cycle is at the given phase thereof.
- the given phase includes an end-diastolic phase of the cardiac cycle
- the control unit is configured to actuate the valve to expand in response to the sensor sensing the end-diastolic phase of the cardiac cycle.
- the tool includes a septal-closure device configured to be implanted within a heart of the subject by mechanically expanding within the heart, and the control unit is configured to actuate the septal-closure device to expand in response to the sensor sensing that cardiac cyclic activity of the subject is at a given phase thereof.
- the given phase includes an end-diastolic phase of the cardiac cycle
- the control unit is configured to actuate the septal-closure device to expand in response to the sensor sensing the end-diastolic phase of the cardiac cycle.
- apparatus for use with a portion of a subject's body that undergoes neural cyclic activity, the apparatus including:
- a medical tool configured to perform a function with respect to the portion of the subject's body
- control unit configured to actuate the tool to perform the function, in response to the sensor sensing that the cyclic activity is at a given phase thereof.
- apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, and for use with a sensor for sensing a phase of the cyclic activity, and for use with a medical tool configured to perform a function with respect to the portion of the subject's body, the apparatus including:
- control unit configured:
- apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- a medical tool configured to perform a function with respect to the portion of the subject's body
- control unit configured:
- the tool includes a myocardial revascularization tool configured to sequentially apply a revascularization treatment to respective treatment sites within the portion of the subject's body, and the control unit is configured to:
- control unit is configured to move the tool by moving the tool to create a defined pattern of treatment sites.
- the tool includes an ablation tool configured to sequentially ablate respective ablation sites within the portion of the subject's body, and the control unit is configured to:
- the ablation tool is configured to ablate the ablation sites using an ablation technique selected from the group consisting of: laser ablation, electrocautery, RF ablation, cryogenic ablation, and ultrasound ablation.
- control unit is configured to move the at least the portion of the tool by moving the at least the portion of the tool to create a defined pattern of ablation sites.
- control unit is configured to apply a Maze procedure to the ablation sites by moving the at least the portion of the tool toward successive ablation sites.
- the ablation tool is configured to apply a pulmonary vein isolation technique to a heart of the subject by moving the at least the portion of the tool toward successive isolation sites.
- the tool includes an injection tool, configured to inject a substance within the portion of the subject's body, and the control unit is configured to:
- the substance includes DNA molecules
- the injection tool is configured to inject the DNA molecules into heart tissue of the subject.
- the substance includes stem cells
- the injection tool is configured to inject the stem cells into heart tissue of the subject.
- the tool includes a needle configured to suture tissue within the portion of the subject's body, and the control unit is configured to:
- the tissue includes tissue of the subject selected from the group consisting of cardiac tissue and coronary tissue, and the needle is configured to suture the selected tissue.
- the tool includes a needle configured to aspirate tissue from an aspiration site within the portion of the subject's body, and the control unit is configured to:
- the needle is configured to perform trans-thoracic needle aspiration.
- the needle is configured to perform trans-bronchial needle aspiration.
- apparatus for opening an at least partial occlusion of a lumen of a subject's body including:
- an occlusion-opening tool configured to open the occlusion
- control unit configured:
- control unit after actuating the tool at the given phase of the first cycle and before the actuation of the tool at the given phase of the subsequent cycle, the control unit is configured to retract the tool from the occlusion.
- the occlusion-opening tool includes a tool configured to open the occlusion by directing acoustic waves toward the occlusion.
- apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- an imaging device for acquiring a plurality of image frames of the portion of the subject's body
- a medical tool configured to perform a function with respect to the portion of the subject's body
- control unit configured to:
- a display configured to facilitate use of the tool by displaying the stabilized set of image frames of the medical tool disposed within the portion of the subject's body.
- the apparatus further includes a user interface
- the control unit is configured to receive an input from a user, via the user interface, and to designate the given phase in response to the input.
- the tool includes a valve configured to be implanted within the portion of the subject's body by being expanded within the portion, and the control unit is configured to actuate the valve by expanding the valve.
- the tool includes a septal-closure device configured to be implanted within the portion of the subject's body by being expanded within the portion, and the control unit is configured to actuate the septal-closure device by expanding the septal closure device.
- the tool includes a balloon configured to perform the function by being inflated inside a lumen of the portion of the subject's body.
- the tool includes a tubular structure configured to bypass an occlusion of a blood vessel within the portion of the subject's body.
- the tool includes a myocardial revascularization tool configured to sequentially apply a revascularization treatment to respective treatment sites within the portion of the subject's body, and the control unit is configured to:
- the tool includes an ablation tool configured to sequentially ablate respective ablation sites within the portion of the subject's body, and the control unit is configured to:
- the tool includes an injection tool configured to inject a substance within the portion of the subject's body and the control unit is configured to:
- the tool includes a needle configured to suture tissue within the portion of the subject's body, and the control unit is configured to:
- the tool includes a needle configured to aspirate tissue from an aspiration site within the portion of the subject's body, and the control unit is configured to:
- the tool includes an occlusion-opening tool configured to perform the function by performing an occlusion-opening action on an at least partial occlusion of a lumen of the portion of the subject's body.
- the tool is configured to perform the occlusion-opening action by moving toward the occlusion, and after actuating the tool at the given phase of a first cycle and before the actuation of the tool at the given phase of a subsequent cycle, the control unit is configured to retract the tool from the occlusion.
- control unit is configured to generate the stabilized set of image frames by image tracking at least some of the plurality of image frames to reduce imaged motion of the portion of the subject's body associated with the cyclic activity.
- control unit is configured to generate the stabilized set of image frames by generating a set of tracked image frames corresponding to image frames of the portion acquired during the given phase.
- control unit is configured to generate the stabilized set of image frames by generating a set of the image frames corresponding to image frames of the portion acquired during the given phase.
- control unit is configured to reduce imaged motion of the portion of the subject's body associated with motion of the portion of the subject's body by image tracking the set of image frames.
- control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase, by actuating the imaging device to acquire the plurality of image frames only when the cyclic activity is at the given phase.
- the imaging device is configured to acquire the plurality of image frames throughout the cyclic activity
- the control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase by selecting image frames corresponding to image frames of the portion acquired during the given phase from the plurality of image frames.
- control unit is configured to generate an additional stabilized set of image frames of the portion of the subject's body, by identifying a further given phase of the cyclic activity of the body system, and generating a set of the image frames corresponding to image frames of the portion acquired during the further given phase.
- the cyclic activity includes a cardiac cycle of the subject
- the sensor includes a sensor for sensing a phase of the subject's cardiac cycle.
- the given phase includes an end-diastolic phase of the subject's cardiac cycle
- the control unit is configured to generate a stabilized set of the image frames corresponding to image frames of the portion acquired during the end-diastolic phase of the subject's cardiac cycle.
- the senor includes an image processor configured to sense movement of the portion of the subject's body by comparing image frames of the plurality of image frames to at least one of the plurality of image frames.
- the cyclic activity includes a respiratory cycle of the subject
- the sensor includes a sensor for sensing a phase of the subject's respiratory cycle.
- the senor includes an image processor configured to sense movement of the portion of the subject's body by comparing image frames of the plurality of image frames to at least one of the plurality of image frames.
- the apparatus further includes an instrument configured to be operated by a user, and the control unit is configured to actuate the tool to perform the function, (a) in response to the sensor sensing that the cyclic activity is at the given phase thereof, and (b) in response to the instrument being operated by the user.
- the instrument is configured to provide force feedback to the user that is independent of the cyclic activity.
- the instrument is configured to provide force feedback to the user that is smoothened with respect to the cyclic activity.
- apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, and for use with an imaging device for acquiring a plurality of image frames of the portion of the subject's body, a sensor for sensing a phase of the cyclic activity, a medical tool configured to perform a function with respect to the portion of the subject's body, and a display configured to facilitate use of the tool by displaying image frames of the portion of the subject's body, the apparatus including:
- control unit configured to:
- apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- an imaging device for acquiring a plurality of image frames of the portion of the subject's body
- a medical tool configured to mechanically perform an action during a single cycle of the cyclic activity with respect to the portion of the subject's body
- control unit configured to:
- control unit is configured to generate the stabilized set of image frames by generating a set of image frames that are stabilized with respect to the given phase of the cyclic activity.
- the tool includes a balloon configured to apposition itself to a lumen of the portion of the subject's body during a single cycle by being inflated, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- the tool includes a stent configured to be implanted by being expanded inside a lumen of the portion of the subject's body during a single cycle of the cyclic activity, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- the tool includes a valve configured to be implanted within the portion of the subject's body by mechanically expanding within the portion during a single cycle of the cyclic activity, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- the tool includes a septal-closure device configured to be implanted within a heart of the subject by mechanically expanding within the heart during a single cycle of cardiac cyclic activity of the subject, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- FIG. 1 is a schematic illustration of apparatus for generating a stabilized image of a portion of a subject's body, in accordance with an embodiment of the present invention
- FIG. 2 is a schematic illustration of a heart at various phases of the cardiac cycle alongside an ECG signal associated with the cardiac cycle;
- FIG. 3 is a schematic illustration of image frames of a subject's heart being gated to a phase of a physiological cycle, in accordance with an embodiment of the present invention
- FIG. 4 is a schematic illustration of image frames of a subject's heart being image tracked, in accordance with an embodiment of the present invention
- FIG. 5 is a schematic illustration of image frames of a subject's heart being (a) gated to a phase of a physiological cycle, and (b) image tracked, in accordance with an embodiment of the present invention
- FIG. 6 is a schematic illustration of apparatus for synchronizing actuation of a medical device with a physiological cycle, in accordance with an embodiment of the present invention
- FIGS. 7A-B are schematic illustrations of the actuation of inflation of a balloon in synchronization with a physiological cycle, in accordance with an embodiment of the present invention.
- FIG. 7C is a graph schematically showing the pressure of the balloon as a function of time, in accordance with an embodiment of the present invention.
- FIG. 8 is a schematic illustration of apparatus for facilitating the synchronized inflation of a balloon, in accordance with an embodiment of the present invention.
- FIGS. 9-11 are schematic illustrations of apparatus for facilitating the synchronized inflation of a balloon, in accordance with another embodiment of the present invention.
- FIG. 12 is a schematic illustration of apparatus for facilitating the synchronized inflation of a balloon, the apparatus being built into an inflation device, in accordance with a further embodiment of the present invention.
- FIG. 13 is a schematic illustration of synchronization of the penetration of an occlusion of a blood vessel with cyclic movement of the blood vessel, in accordance with an embodiment of the present invention
- FIG. 14 is a schematic illustration of a modulator for synchronizing the penetration of an occlusion of a blood vessel with the cyclic movement of the blood vessel, in accordance with an embodiment of the present invention
- FIG. 15 is a schematic illustration of a handheld actuator that comprises the modulator shown in FIG. 14 , in accordance with an embodiment of the present invention.
- FIG. 16 is a schematic illustration of the synchronization of a transluminal placement of a coronary bypass graft with the cyclic motion of a portion of the subject's body, in accordance with an embodiment of the present invention.
- near real time when used in reference to the application of virtual stabilization or of an element thereof, means with a short noticeable delay (such as approximately one or two motion cycles of the applicable organ, and, in the case of procedures relating to organs or vessels the motion of which are primarily as a result of the cardiac cycle, less than 4 seconds).
- apparatus and methods are provided for facilitating medical procedures performed on cyclically-moving organs, so that such procedures are performed under a partial or full virtual stabilization of such organs.
- the virtual stabilization typically comprises two elements, namely (a) the stabilization of the image(s) of the organ and (b) the synchronization of tool(s) being actuated and/or moved, with the movement of the organ. At least one of these two major elements is applied.
- organs which move cyclically include, but are not limited to, the heart, the coronary blood vessels, the aorta, certain other blood vessels (e.g., renal, carotid), the majority of the respiratory tract, certain parts of the digestive tract (e.g., the stomach, the small intestine), certain parts of the thorax (e.g., the diaphragm), the eyes, etc.
- the description hereinbelow relates mainly to the example of the body organ being the heart and/or the coronary blood vessels, and the physiological signal used for synchronization or gating in such examples is typically the ECG.
- the scope of the invention includes applying the apparatus and methods described hereinbelow to any portion of a subject's body that moves as a result of the cyclic activity of a body-system of the subject.
- FIG. 1 is a schematic illustration of apparatus for acquiring image frames of a portion of a subject's heart, in accordance with an embodiment of the present invention.
- An angiographic/fluoroscopic camera 11 acquires a plurality of image frames, throughout the cyclic activity of the heart. When the image frames are not stabilized, an image or video stream 14 is generated, which is blurred due to the cyclical motion of the imaged heart.
- the apparatus generates a stabilized video stream 15 by a gating procedure performed by processor 13 in response to an ECG signal 12 , a blood pressure sensor, a displacement sensor, a vibration sensor and/or any combinations or derivations thereof, thus yielding said stabilized image or video stream 15 .
- the image frames are gated with respect to the subject's respiratory cycle.
- the subject's respiratory cycle is detected by means of a respiration sensor, such as a stretch belt, a displacement sensor, a vibration sensor, and/or any combinations or derivations thereof.
- the aforementioned gating is performed directly in conjunction with the actual expansion and contraction of the heart muscle in the course of the cardiac cycle, as such expansion process is observed by the fluoroscopic/angiographic camera, discerning by means of image processing the relative distances among identifiable features such as the coronary blood vessels.
- gating is performed initially with respect to the ECG signal, or to another signal corresponding to cardiac motion, and/or to any combination or derivation of signals thereof, but afterwards gating is performed by means of image processing. For example, an image frame corresponding to a selected phase in the ECG signal is identified and determined to be a “baseline image frame.” After such identification of a “baseline image frame” has been achieved, gating of the subsequent image stream is done by means of selecting those image frames where the shape of the observed anatomy is identical, or most similar, to the shape observed in the baseline image frame.
- the aforementioned gating is applied directly to the radiation source of the fluoroscopic/angiographic camera, so that imaging is performed intermittently, e.g., only during or leading up to one or more specific phases in the cardiac cycle at which the acquisition of a (gated) image frame is desired.
- the stabilized image frames are typically produced at the rate of the patient's heart rate.
- the resulting frame rate is typically one or two frames per second, which is considered a low-frame rate compared to what the human eye interprets as continuous.
- a gap filling technique is applied among the image frames that were selected for display by the gating. Additional intermediate image frames are generated, thus increasing the visible frame rate, typically smoothening the transitions among the gated and displayed images and making the image stream easier to observe.
- such gap filling utilizes image processing methods such as blending, morphing or a combination thereof.
- the gap-filling techniques include a predictive algorithm that is applied to generate image frames after the most recent gated and displayed image frame, but prior to the next gated and displayed image frame.
- a predictive algorithm that is applied to generate image frames after the most recent gated and displayed image frame, but prior to the next gated and displayed image frame. For example, an image processor determines a characteristic of motion of the tool, based upon previously-acquired image frames. The motion profile is extrapolated to generate a simulated image frame of the tool by assuming that the tool continues to move according to the determined profile. The simulated image frame is then used as an intermediate image between successive image frames.
- visual information from images that were acquired in the original image stream, but are not displayed in the gated image stream may be used to discern some of the changes that have occurred since the most recent gated and displayed image. Those changes are then applied to the most recent gated and displayed image, to generate new image frames ahead of the next gated and displayed image.
- visual information may comprise changes in tool positions relative to visible anatomical landmarks that move together with the heart. Such changes are then applied to the most recent gated and displayed image, leading to a representation of the tool being generated and displayed within the stabilized video stream ahead of the next gated and displayed image frame.
- the gap filling described hereinabove is applied by processor 13 . Typically, it is applied in the transition between every two consecutive gated image frames.
- the resulting, stabilized video stream is typically displayed in the course of the procedure, and typically in real time or in near real time.
- the stabilized video stream is stored and is displayed subsequent to the procedure in which the image frames are acquired.
- two or more of the streams of images are displayed side by side (which may be achieved using two or more separate physical displays, or using two or more software windows within the same physical display).
- the “smoothened,” gated image stream is displayed in a shared manner on the same display that is used for other purposes in the procedure room, such as on an existing “main” or “reference” or “re-loop” display in a coronary catheterization lab.
- FIG. 2 is a schematic illustration of a heart at various phases of the cardiac cycle alongside an ECG signal associated with the cardiac cycle.
- FIG. 2 illustrates the correspondence between triggering points 21 , 22 and 23 in the ECG trace and phases 24 , 25 and 26 in the cardiac cycle. Different points in the ECG trace typically correspond to different phases in the cardiac cycle.
- the volume and shape of the heart typically vary throughout the cardiac cycle.
- the displayed images of the pulsating heart may be gated to any of these points or phases. In some embodiments, the heart may therefore be continuously viewed at a specific volume and/or shape.
- an operator shifts the phase point to view the cardiac image at any desired phase in the cycle of the ECG signal, via an input to processor 13 (shown in FIG. 1 ).
- the specific phase of the cardiac cycle to which the displayed images are gated may be changed by the operator in the course of viewing the images.
- the stabilized video stream is gated specifically to the end of the diastolic phase of the cardiac cycle. (At the end-diastolic phase the ventricles are typically at their peak volume.)
- the inventors hypothesize that the coronary blood vessels may be spread apart at the end-diastolic phase of the cardiac cycle, and, for example, in the case of an angioplasty procedure, that may be the view most desired by a physician.
- the stabilized video stream is gated to a different phase of the subject's cardiac cycle, for example, systole, or mid-diastole.
- more than one stabilized video stream is displayed concurrently. For example, a stabilized video stream at a diastolic phase of the cardiac cycle is displayed concurrently with another stabilized video stream at a systolic phase of the cardiac cycle.
- the gated images at different phases of the cardiac cycle form a basis for determining a parameter of the subject's cardiovascular system, for example, the ejection fraction of the heart (using image processing techniques known in the art, mutatis mutandis).
- image streams are stabilized with respect to two or more phases of the subject's respiratory cycle, and a parameter of the subject's respiratory cycle is determined using one, or both of the image streams, for example, by comparing the image streams to each other.
- the subject's tidal volume may be determined by determining from the image streams the size of the subject's lungs at the end of the exhalation phase of the subject's respiratory cycle and the size of the subject's lungs at the end of the inhalation phase of the cycle.
- processor 13 stabilizes the image of the portion of the subject's body with respect to additional motion of the portion.
- Some physiological signals or processes correspond to a change in the shape of the organs being imaged.
- Other signals or processes mainly correspond to a change in the location of such organs but have less of a correspondence to their shape.
- signals or processes of those two categories apply to a certain organ or organs concurrently. For example, in the case of the heart and the coronary blood vessels, those organs typically twist, contract and expand in the course of the cardiac cycle (also corresponding to the ECG signal), while at the same time they also typically shift up and down in the course of the respiratory cycle.
- organs may shift in a non-cyclical manner due to “whole-body motion” of the subject, for example, due to the subject coughing or moving on his/her bed.
- Whole-body motion is to be understood as referring to non-cyclical, noticeable motion of an external portion of the subject's body, even in the absence of the subject's entire body moving.
- a cyclical signal or process typically corresponding to a change in the shape(s) of such organ(s) is accounted for by means of gating.
- another signal or process, typically corresponding mainly to a change in the location of such organs is accounted for by means of an image tracker.
- gating to the ECG signal is applied to create one or more video streams, each of which is stabilized with respect to a specific phase in the cardiac cycle.
- Image tracking is then applied to the aforementioned gated video stream(s) in order to further stabilize the stream(s) with respect to the respiratory cycle.
- gating followed by image tracking is applied to respective image frames, in a frame-by-frame manner, such that an individual gated frame is image tracked prior to the next gated frame being acquired.
- gating is applied to a batch of image frames to generate a set of gated image frames.
- Image tracking is then applied to the set of gated image frames.
- the image tracker is applied to motion that is typically not of a cyclical nature, such as whole-body motion of the patient in the course of the procedure. As a result, such motion of the patient is absent from, or substantially reduced in, the stabilized image stream being viewed by the physician.
- the sequence in which the aforementioned gating, image tracking and gap filling are applied to images in the originally-acquired image stream may vary.
- the typically higher frequency of two physiological signals or processes corresponding to a motion of said organ is gated, and subsequently the signal or process which is typically of a lower frequency, and/or any additional motion of the organ, is accounted for by means of image tracking.
- image tracking may reduce the computational resources required for image stabilization.
- the typically lower frequency of the two physiological signals or processes is gated, and the signal or process which is typically of a higher frequency, and/or any additional motion of the organ, is accounted for by means of image tracking.
- the stabilization of the video stream of the cyclically-moving organ is achieved by accounting for the second aforementioned signal or process by means of image tracking prior to (and not following) accounting for the first aforementioned signal or process by means of gating.
- a sequence may be useful in some of the aforementioned gap-filling algorithms.
- visual information of changes in tool positions relative to anatomical landmarks is easier to identify in image tracked images before the images are gated.
- image tracking followed by gating is applied to respective image frames (typically, in real time or near real time).
- image frames typically, in real time or near real time.
- a batch of image frames are image tracked and subsequently the tracked image frames are gated.
- image frames are gated with respect to the respiratory cycle, and are image-tracked with respect to movement related to the subject's cardiac cycle.
- the image tracker applied in the aforementioned embodiments may be an edge tracker, a centroid tracker, a correlation tracker, an object tracker, or any combination thereof.
- Such image tracker typically neutralizes, in the eyes of the viewer of a stabilized video stream, the change in location of the organs being imaged, thus maintaining the organ at a desired location on the display (such as its center), even though the organ being imaged is in constant motion.
- FIG. 3 is a schematic illustration of a video stream 33 of a subject's heart being gated to a phase of the subject's cardiac cycle, in accordance with an embodiment of the present invention.
- a video camera 31 acquires a video stream 33 of the subject's heart.
- An ECG 32 detects the subject's cardiac cycle.
- a gating processor 34 of control unit 13 selects image frames 35 corresponding to a given phase of the cardiac cycle as reflected by a given point in ECG 32 .
- a buffer 36 is used for gap filling the transitions among images 35 .
- the resulting stabilized video stream is presented on display 37 . Reference is now made to FIG.
- video stream 41 is the output of gating processor 34 ( FIG. 3 ).
- a mask 45 is generated from image frames of video stream 41 of the subject's heart. Both mask 45 and the image frames are fed into a correlator 42 .
- Correlator 42 identifies mask 45 in each new image frame, and by doing so identifies the deviation in the location of the mask within the current image frame relative to its location in the prior image frame.
- Image corrector 43 utilizes the output of correlator 42 for realigning each new image frame such that the relative location of mask 45 within each such new image frame remains constant. Consequently, tracked video stream 44 is produced.
- video stream 44 is both image tracked and gated to a given point in the ECG.
- FIG. 5 is a schematic illustration of a video stream of a subject's heart being (a) gated 51 to a phase of a physiological cycle (as described with reference to FIG. 3 ), and (b) image tracked 52 (as described with reference to FIG. 4 ), in accordance with an embodiment of the present invention.
- the combined application of processes 51 and 52 typically results in a video stream that is stabilized with respect to changes in the shape as well as the location of the organ(s) being imaged.
- each individual image frame which is an output of the gating serves as an input for image tracking.
- each individual frame becomes both gated and image tracked, and the gap filling is performed on the transformations between successive gated-and-image-tracked frames.
- the scope of the present invention also includes performing image tracking prior to performing gating (configuration not shown in the figures).
- the smoothening algorithms described herein are generally applied to the output of the gating.
- a path for passing tools into desired locations in the heart and/or coronary blood vessels is generated. In some embodiments, such a path is also displayed.
- stabilized road mapping is applied to cyclically-moving organs such as the coronary blood vessels, the pulmonary vessels, the aorta, and/or to the heart itself.
- Road mapping is typically helpful in reducing radiation time and/or the amount of contrast agent being used to facilitate medical procedures.
- Road mapping is commonly used in catheterization procedures in organs that can typically remain motionless throughout the procedure, such as blood vessels in the limbs.
- One embodiment of road mapping is named Digital Subtraction Angiography (DSA).
- road mapping is typically difficult with conventional, constantly moving cardiac images, because the historical roadmap and the displayed images are typically not aligned with one another most of the time.
- road mapping is typically not used in procedures performed on moving organs, such as coronary interventions.
- a historical roadmap which was generated in the same phase of the cardiac cycle to which the displayed, stabilized video stream is gated and from the same viewing angle, is displayed as a background to the real-time, stabilized video stream.
- the roadmapping typically generates an image of the coronary vessels highlighted with a contrast agent. Consequently, the real-time image of tools inserted through such vessels is typically viewed as superimposed on the roadmap of those same vessels at the same gated phase in the cardiac cycle.
- by generating a stabilized roadmap manipulation of tools is facilitated, and/or cumulative radiation throughout the procedure is reduced, and/or the cumulative amount of contrast agent injected throughout the procedure is smaller.
- the contrast agent is injected into a space within the subject's cardiovascular system, for example, a chamber of the subject's heart, a coronary blood vessel, and/or the subject's aorta.
- using roadmapping facilitates the direct stenting of the subject's coronary arteries, without requiring a prior step of pre-dilatation.
- the roadmap typically improves the ability to place the stent accurately and thus reduces the need to inflate a balloon which does not carry a stent prior to the deployment of the stent itself. That, in turn, typically reduces procedure time and/or cost.
- direct stenting as described herein is capable of reducing the risk of embolization which may otherwise be created if pre-dilatation is performed at a slightly different location from that of the subsequent deployment of the stent. If such a difference in location exists, then the occluding substance or tissue that is being inflated and fragmented by a pre-dilatation balloon may not be subsequently kept in place by the stent, and thus embolization might occur.
- the injection of contrast agent for highlighting the vessels is sensed, for the purpose of generating the aforementioned roadmap, via an electrical signal indicating the activation of the injection sub-system.
- the injection of contrast agent for highlighting the vessels is identified by means of image processing.
- the injection of contrast agent for highlighting the vessels is identified by means of analyzing changes in the image (such as via a histogram) of the region at the distal end of the catheter from which the contrast agent typically comes out (such as a guiding catheter in the case of coronary road mapping).
- Changes in the image include a relatively abrupt change in the color and/or grayscale level (darkness) of a relatively large number and/or portion of image pixels, or the appearance of vessel-like features in the image, etc., or any combination thereof. It is noted that by assessing a change in the darkness level to identify the time of injection of the contrast agent, the control unit may identify a darker area of the image or a lighter area of the image, depending on whether the contrast agent is represented as dark or light. It is additionally noted that whereas specifically assessing the region at the distal end of the catheter typically enhances signal to noise (because this region is most likely to show an abrupt change), the scope of the present invention includes assessing all of the acquired image data to identify the injection of the contrast agent.
- the road map being displayed in conjunction with the stabilized video stream loops among multiple images of different moments in the injection and dissipation process of the contrast agent, wherein all of those images were originally gated to a same phase in the cardiac cycle to which the currently-displayed, stabilized video stream is gated.
- the road map being displayed in conjunction with the stabilized video stream comprises an image of the contrast agent itself.
- the road map comprises a synthesized background(s), enhancement(s), contour(s), pattern(s), texture(s), shade(s) and/or color(s) that was created based upon the visual information acquired from the injection and/or dissipation of contrast agent, using computer graphics and/or image processing techniques.
- the gray level of the road map is inversed, such that the road map appears light against a darkened background.
- the summation or combination of two road maps generated at different times in the procedure is displayed.
- a road map generated during a given phase of a first cardiac cycle is summed with a road map generated during a same phase of a second (typically immediately subsequent) cardiac cycle, to create a combined road map that displays more coronary vessels and/or displays coronary vessels with greater clarity.
- the combined road map may comprise the summation or combination of a roadmap created from an injection of a contrast agent proximally to the occlusion, and a second road map created from an injection of a contrast agent distally to the occlusion, such as via a collateral vessel and/or in a retrograde direction.
- the roadmaps based on the proximally- and distally-injected contrast agent are created in the same phase of one or more cardiac cycles that are not necessarily adjacent cardiac cycles.
- a three-dimensional road map is constructed by combining two or more two-dimensional road maps recorded from viewing angles that are typically different by 30 degrees or more.
- the two two-dimensional road maps (from which a three-dimensional road map is constructed) are recorded concurrently from two different viewing angles by means of a bi-plane fluoroscopy system.
- a three-dimensional road map is created from CT angiography images, typically pre-procedural ones, and then correlated with the real-time two-dimensional road map created from intra-procedural angiography.
- a three-dimensional road map is constructed from two or more different images taken from the same viewing angle but during different phases in the cardiac cycle.
- markings are applied upon the stabilized images.
- markings may be applied to the longitudinal edges of an occlusion, or to the region in which pre-dilatation was performed, etc.
- markings are applied manually with an input device such as a computer mouse, or by a stylet in the case of a tablet computer.
- markings are applied by hand on a touch screen.
- markings appear to the viewer, throughout subsequent changes in the viewing angle and/or zoom level or the fluoroscopy/angiography system, as if they remain attached to the blood vessels to which they refer.
- Such virtual attachment is typically performed by means of image processing.
- the markings comprise a scale or a grid that is generated on the stabilized image, to indicate to the physician the dimensions of the image.
- on-line geometric and/or hemodynamic measurements are made and/or displayed upon the stabilized images.
- “On-line” in this context means that the measurements are made on the stabilized image stream, as opposed to being made on frozen images extracted from an image stream.
- such measurements also known as Quantitative Coronary Analysis (QCA)
- QCA Quantitative Coronary Analysis
- the known size of an object seen in the stabilized images such as the outer diameter of an introducing catheter or the size of a patch adhered to the patient's chest or the distance between radiopaque markers on a tool, is used as a reference in making such measurements.
- the orientation at which the medical tool is disposed within the subject's body is determined, by determining an apparent distance between radiopaque markers on a tool within the stabilized set of image frames, with respect to the known distance of the markers from each other.
- the physical size corresponding to an image pixel, as known from the imaging system is used as a reference (in which case no physical reference object is required).
- the deployment of an endovascular device is visually simulated prior to actually being performed.
- a virtual stent of selected length and diameter may be visually placed and displayed, within the stabilized image stream, as if it were situated at the site of the occlusion. The suitability of the intended dimensions as observed with the virtual stent can then be visually validated by the physician prior to selecting and deploying the physical stent.
- multiple virtual stents such as in preparation for the stenting of a vascular bifurcation where a physical stent will be required in each branch, are virtually placed and matched with one another prior to their actual deployment.
- a virtual stent is placed in proximity to a physical, already-deployed stent to verify that the two match one another prior to deploying the second, physical stent.
- the proper deployment of a virtual tool is estimated by viewing it upon two stabilized images streams, each corresponding to a different phase of the cardiac cycle.
- one such phase is diastolic while the second phase is systolic.
- the virtual tool in response to determining an orientation at which a real medical tool (e.g., a catheter) is disposed within the subject's body, the virtual tool is deployed at a corresponding (e.g., identical) orientation.
- an operator manipulates an image of a virtual tool deployed within the stabilized image stream, until the virtual tool is of appropriate dimensions.
- a reference number of a real tool that best corresponds to the dimensions of the virtual stent is generated. (The reference number may be, for example, a catalog number of a real tool.)
- the dimensions of a real tool that corresponds to the dimensions of the virtual tool are generated.
- image processing is applied to the simulated image of the virtual stent to determine the curvature of a region in which the virtual stent is deployed and dimensions of a real tool are generated that incorporate the curvature of the region.
- the orientation of the region in which the virtual tool is deployed is determined in order to generate the dimensions of a corresponding real tool.
- the proper deployment of an actual stent is assessed by viewing the stent within two stabilized images streams, each corresponding to a different phase of the cardiac cycle.
- one such phase is diastolic, while the second phase is systolic.
- image processing techniques are applied to enhance the image of (a) an endovascular device, and/or (b) radiopaque markers which a device comprises, and/or (c) the walls of the vessel in which the device is situated, within the stabilized image stream.
- the device may be a balloon and/or a stent that is implanted in the subject's body or that is transiently placed within the subject's body.
- such enhancement is more easily generated in a stabilized video stream in which the enhanced object is relatively stable, compared with in a non-stabilized stream of images wherein the object being enhanced is constantly shifting.
- such enhancement may be performed on-line, within the stabilized image stream. Consequently, in such embodiments, proper deployment of the endovascular device being deployed may be verified by the physician during a procedure.
- the stabilized image stream is used for on-line measurement of the flow within a vessel, by measuring the time it takes contrast agent to travel a known distance. In some embodiments, the stabilized image stream is used for on-line measurement of the saturation of contrast agent within targeted tissue, such as heart muscle.
- additional images such as images produced by other modalities in a same or similar phase of the cardiac cycle to which the stabilized video stream is gated, are co-displayed.
- images are pre-operative, intra-operative, or a combination of the two.
- images are two-dimensional or three-dimensional.
- the modalities from which such images originate are used before or during coronary procedures and include, without limitation, fluoroscopy, CT, MRI, CT angiography, Trans Esophageal Echo (also known as TEE), Trans Thoracic Echo (also known as TTE), Intra Vascular Ultrasound (also known as IVUS), Intra Cardiac Ultrasound (also known as Intra Cardiac Echo, or ICE), Optical Coherence Tomography, Intra Vascular MRI, or any combination thereof.
- the co-display of such images together with the aforementioned gated video stream is performed via fusion (e.g., image overlay), using image-to-image registration techniques.
- fusion e.g., image overlay
- overlay and derivations thereof, should not be understood to denote a particular order in which two or more images are combined. Rather, it refers generally to the combination of two or more images that are overlaid in space.
- a first set of images are acquired by a first imaging device from outside a portion of the subject's body, for example by CT or using a fluoroscope.
- a second set of images are acquired by a second imaging device from within the portion of the subject's body, for example, using an intra-vascular ultrasound probe, or an intra-vascular MRI probe.
- the first set of images are acquired before the second set of images are acquired, and the two sets of images are registered to each other.
- the first imaging device and the second imaging device acquire the respective sets of image frames simultaneously.
- images generated by an ultrasound probe (such as IVUS) within a coronary vessel are used in conjunction with the stabilized image stream (such as a stabilized fluoroscopic image stream) in the following manner:
- An IVUS catheter is inserted to the site of an occlusion under fluoroscopic imaging, to inspect endoluminal anatomy.
- the image slices generated by the IVUS are recorded and stored in tandem with the visual location (such as display coordinates) of the distal tip of the IVUS catheter as seen by the fluoroscopy.
- the IVUS catheter is retrieved to make room for balloon/stent deployment.
- a catheter with a balloon and/or stent is inserted to the site of the occlusion, under fluoroscopic imaging.
- the location of the distal tip of the catheter carrying the balloon and/or stent is visually recognized (such as via display coordinates).
- the IVUS images previously recorded at the same location are displayed, together with the fluoroscopic images.
- the IVUS images are displayed in a separate window (but on the same screen as the fluoroscopic images).
- the IVUS images are displayed on a separate screen.
- the IVUS images being displayed are two-dimensional (also known as “slices”).
- a three-dimensional “tunnel-like” reconstruction of the IVUS images of the vessel (or a section thereof) is displayed.
- the IVUS images are overlaid on the fluoroscopic images.
- the IVUS images are fused with the fluoroscopic images.
- the balloon and/or stent may be deployed based upon an on-line combination of real-time fluoroscopic images and of IVUS images recorded earlier (for example, several minutes earlier).
- embodiments of the invention are, described primarily with reference to the heart, connecting vessels (e.g., aortic, pulmonary) and coronary blood vessels, embodiments of the current invention are similarly applicable to any other organ affected by periodic motion and/or periodic activity. An example for the latter would be the brain.
- FIG. 6 is a schematic illustration of apparatus for synchronizing actuation of a medical device with a physiological cycle, in accordance with an embodiment of the present invention.
- Cyclically-moving organ 61 is imaged by imaging device 62 .
- Non-gated image frames are displayed on display 64 .
- a cyclical physiological signal used for synchronization is transmitted via line 68 to processor 63 .
- Gated image frames are displayed on display 66 , which is connected to processor 63 .
- gap filling is applied to the gated image frames.
- such images are also image tracked.
- Actuator 65 is actuated in a synchronized manner, with respect to the synchronization signal transferred from processor 63 via a line 69 .
- Actuator 65 controls tool 67 , which is applied to organ 61 .
- the scope of the present invention includes synchronizing, with respect to a physiological cycle, the actuation and/or movement of a medical device that performs a function on a portion of a subject's body, without stabilizing images of the portion,
- the scope of the present invention includes synchronizing, with respect to a physiological cycle, the actuation and/or movement of a medical device that performs a function on a portion of a subject's body, in combination with stabilizing images of the portion.
- the scope of the present invention includes synchronizing, with respect to a given phase of a physiological cycle, the actuation and/or movement of a medical device that performs a function on a portion of a subject's body, and stabilizing images of the portion with respect to the same given phase of the cycle.
- FIGS. 7A-C and 8 through 12 are schematic illustrations of apparatus for inflation of a balloon, such as for widening an occlusion within a coronary blood vessel, in synchronization with the patient's cardiac cycle, in accordance with respective embodiments of the invention.
- a stent which is positioned around the balloon, is expanded by inflating the balloon.
- the embodiments shown in FIGS. 7-12 are practiced in combination with stabilized imaging techniques described hereinabove.
- the placement and inflation of the balloon is performed in a same selected specific phase of the cardiac cycle. That typically leads to accuracy in the placement of the balloon at a given location.
- inflation in some embodiments is performed in an intermittent (i.e., a stepwise) manner, in the course of a same selected phase in multiple cardiac cycles ( FIG. 7C ).
- one or more segments of the inflation of the balloon is performed continuously (i.e., not in synchronization to the cardiac cycle) and one or more segments of the inflation of the balloon is performed in the aforementioned synchronized, stepwise manner.
- synchronized inflation until the balloon becomes fixed to the inner wall of the lumen is followed by continuous inflation until the balloon is inflated to a target diameter or volume.
- the balloon is inflated continuously till it reaches a given volume but is not yet fixed to the inner walls of the lumen, followed by synchronized inflation until it becomes fixed to the inner walls of the lumen.
- the balloon is first inflated continuously until it reaches a given volume, then inflated in a synchronized manner until it becomes attached to the inner wall of the lumen, and then inflated continuously again until it reaches a desired diameter or volume.
- the aforementioned synchronized placement and inflation are performed while viewing the aforementioned stabilized image as described with reference to FIG. 1 .
- the specific phase to which the inflation of the balloon is synchronized is the end of the diastole phase of the cardiac cycle.
- the ventricles are typically at their fullest volume.
- the inventors hypothesize that during the end-diastolic phase of the cardiac cycle, the coronary arteries are typically the most spread apart, and typically remain in that situation for a fraction of a second. Such timing may further assist in the correct apposition of a stent positioned upon the balloon.
- the inflation of the balloon is gated to a different phase of the subject's cardiac cycle, for example, a mid-diastolic phase or a systolic phase.
- FIGS. 7A-B are schematic illustrations of the actuation of inflation of a balloon 73 in synchronization with a physiological cycle, in accordance with an embodiment of the present invention.
- blood vessel 71 is clogged by occluding substance or tissue 72 .
- Balloon 73 is positioned at the occlusion and inflated by actuator 75 via a tube.
- a synchronization signal derived from the patient's ECG is provided via line 74 .
- the ECG signal is used to trigger the increased inflation pressure of balloon 73 in a stepwise manner, wherein each step occurs in the same selected phase of the ECG cycle.
- the result is sequence 76 ( FIG. 7B ), showing the steady, synchronized stepwise inflation of the balloon, until the balloon is typically inflated to the desired extent and at is the desired location.
- actuator 75 is connected to a typically non-synchronized inflation device. In another embodiment, actuator 75 and the inflation device are integrated together into a single, synchronized inflation device.
- FIG. 7C is a graph showing the pressure 77 of the balloon as a function of time, in accordance with an embodiment of the present invention.
- FIG. 8 is a schematic illustration of apparatus for facilitating the synchronized inflation of a balloon 82 , in accordance with an embodiment of the present invention.
- the operator of the device actuates a handle 81 (such as via rotating), in order to inflate balloon 82 .
- Handle 81 by means of control circuit 83 , commands driver 84 .
- Driver 84 is synchronized by a train of pulses 85 (which originates from the ECG as explained previously), such that it produces a synchronous output into a torque motor.
- the torque motor comprises a stator 86 and rotor 87 .
- the torque motor rotates a lead screw 88 .
- Stationary drive nut 89 converts the rotational motion of lead screw 88 into the linear motion of piston 810 .
- the motion of piston 810 inside cylinder 811 pushes the fluid contained within the distal portion of cylinder 811 into inflation tube 812 , and from there into balloon 82 .
- FIGS. 9-11 are schematic illustrations of apparatus for facilitating the synchronized inflation of a balloon, in accordance with another embodiment of the present invention.
- Inflation device 91 and balloon catheter 92 are typically the same as those conventionally used for non-synchronized balloon inflation.
- synchronization of balloon inflation to the patient's cardiac cycle is enabled by an accumulator-modulator 93 that is added and is typically connected between inflation device 91 and balloon catheter 92 .
- the output of inflation device 91 typically in the form of inflation fluid, feeds accumulator-modulator 93 .
- the output of accumulator-modulator 93 typically in the form of inflation fluid, feeds balloon catheter 92 .
- the purpose of accumulator-modulator 93 is to enable intermittent balloon inflation that is performed, in whole or in part, in a stepwise manner and in synchronization with the patient's ECG signal.
- the modulator part of 93 is typically responsible primarily for the synchronization of the inflation to the ECG.
- the accumulator part of 93 is typically responsible primarily for maintaining a continuous build-up of the inflation pressure despite the inflation itself being (in whole or in part) intermittent. (Without the accumulator, undesirable increases and decreases in the inflation pressure may occur.)
- FIG. 10 is a schematic illustration of an embodiment of accumulator-modulator 93 described with respect to FIG. 9 .
- the accumulator unit comprises a loaded piston 101 .
- the modulator unit comprises valve 102 , driver circuit 103 and internal power supply 104 .
- Internal power supply 104 is optional, as an alternative to an external power supply.
- Driver circuit 103 is fed by the ECG-derived synchronization signal via line 107 , and based on that signal drives valve 102 to assume the open and closed positions.
- the accumulator-modulator receives its input, typically in the form of inflation fluid, from an inflation device via inlet 105 .
- the accumulator-modulator typically provides its output, typically in the form of inflation fluid, to a balloon catheter via outlet 106 .
- the modulator unit of the accumulator-modulator described with respect to FIG. 9 and FIG. 10 typically comprises a valve that opens and shuts in accordance with the ECG-derived synchronization signal and through which the inflation fluid traverses.
- a valve may comprise any known implementation, including a check valve of any type (e.g., ball check, duckbill, swing check, clapper, stop check), a leaf valve, or any combination thereof.
- FIG. 11 is a detailed schematic illustration of the accumulator-modulator described with respect to FIG. 9 and FIG. 10 , in accordance with an embodiment of the present invention.
- Inflation fluid traverses flexible tube 111 on its way towards the outlet of the accumulator-modulator.
- Tube 111 changes intermittently between being open and shut for the flow of such fluid.
- Two arms 112 pivoting on axes 115 , intermittently squeeze and release tube 111 .
- the activation of coil 113 causes arms 112 to pull closer to one another for minimizing the magnetic field reluctance, and thus squeeze tube 111 shut.
- arms 112 (with the assistance of an optional recoil spring 114 ) pull apart and cause tube 111 to open for the passage of inflation fluid.
- FIG. 12 is a schematic illustration of apparatus for facilitating the synchronized inflation of a balloon, the apparatus being built into an inflation device, in accordance with a further embodiment of the present invention.
- a pressure signal 125 is created by inflation mechanism 126 .
- An ECG-derived synchronization signal 121 and pressure signal 125 are both fed into controller 122 .
- a synchronized actuation signal 123 is fed from controller 122 to valve modulator 124 .
- the output of valve modulator 124 typically in the form of inflation fluid, is fed into a balloon catheter that is typically connected distally to the inflation device. As a result, the balloon is inflated gradually, in a stepwise manner, to a desired size.
- Each of the aforementioned balloon inflation apparatuses and methods, described with respect to FIGS. 7 through 12 may be synchronized either to the patient's ECG signal, blood pressure signal, displacement signal, vibration signal or to a different signal corresponding to the patient's cardiac cycle, or to any combination, derivation, extrapolation or manipulation thereof.
- the aforementioned balloon inflation apparatuses and methods described with respect to FIGS. 7 through 12 apply not only to the placement and inflation of a balloon, but also to the deployment of a stent which is positioned upon the balloon.
- deploying a stent in a virtually stable environment leads to greater accuracy in the placement of the stent at a given location.
- other medical tools which are positioned upon the balloon are deployed via the inflation of the balloon. For example, a valve, a graft, a septal-closure device, and/or another medical tool may be deployed via the inflation of the balloon.
- the aforementioned balloon inflation apparatus and methods described with respect to FIGS. 7 through 12 provide the operator of the inflation device with continuous force feedback during inflation.
- the operator of the inflation device typically feels as if the balloon inflation process is continuous even though that process, or parts thereof, is in fact intermittent.
- the apparatus smoothens the force feedback with respect to the physiological cycle to which the inflation is gated, so that the effect of the stepwise inflation, on the force feedback to the operator, is reduced.
- FIGS. 13 through 15 disclose embodiments of the synchronized application of a guide wire, such as for opening an occlusion in a coronary blood vessel, in accordance with an embodiment of the present invention.
- application of the guide wire is synchronized either to the patient's ECG signal, or to a different signal corresponding to the patient's cardiac cycle, or to any combination, derivation, extrapolation or manipulation thereof.
- FIG. 13 is a schematic illustration of synchronization of the penetration of an occlusion 132 of a blood vessel 131 with cyclic movement of the blood vessel, in accordance with an embodiment of the present invention.
- a total or near-total occlusion such penetration typically precedes the inflation of a balloon and/or the placement of a stent.
- Wire 133 penetrates the occlusion in a synchronized, stepwise manner.
- An actuator 135 synchronized by signal 134 coming from the patient's ECG, is used to generate the stepwise forward motion as seen in schematic sequence 136 .
- such synchronized forward motion of the wire 133 enables these embodiments of the current invention to reduce the probability of perforation or dissection of blood vessel 131 by the guide wire.
- perforation or dissection is known to occur, typically due to pushing the wire at a phase in the cardiac cycle where the wire actually points at the wall of the vessel and not towards the desired point of entry on the surface of the occlusion.
- synchronization is made to a phase in the cardiac cycle when the coronary arteries are typically maximally inflated and thus with the largest cross section. Such timing may assist in opening the occlusion.
- the operator feels as if he or she pushes the wire continuously, while the actuator causes the wire to be pushed intermittently, in synchronization with the ECG signal.
- the aforementioned synchronization is applied to a tool used for widening or opening occlusions, where the tool is not a guide wire.
- synchronization is applied to the tool's motion within the occlusion.
- an occlusion-opening tool for example a tool having jackhammer-like functionality, is moved toward the occlusion during the given phase of respective cycles.
- synchronization is used to control the release of energy, for example, ultrasonic energy, aimed at widening or opening the occlusion.
- FIG. 14 is a schematic illustration of a modulator for synchronizing the penetration of an occlusion of a blood vessel by a wire 141 with the cyclic movement of the blood vessel, in accordance with an embodiment of the present invention.
- the modulator generates stepwise motion of wire 141 .
- the modulator disclosed herein is an embodiment based on a self-locking clamp 143 driven by a voice coil incorporating a coil plunger 145 and a permanent magnet stator 146 .
- a return spring 142 is also incorporated.
- Other modulators capable of generating periodic motion that are known in the art include, but are not limited to, those based on roller wheels, grippers, or piezoelectric or magnetostrictive effects.
- the modulator is typically housed in shell or housing 144 .
- Wire 141 can be placed into the modulator at any desired position along the wire, for example after the interventional cardiologist has already pushed the wire all the way to the occlusion.
- similar modulating heads yield rotational motion of the wire by adding a torque generator to the modulator.
- FIG. 15 is a schematic illustration of a handheld actuator that comprises the modulator described with respect to FIG. 14 , in accordance with an embodiment of the present invention.
- Electronic circuit 152 conveys a driving signal to modulator 153 , in the manner already described with respect to FIG. 14 .
- Control stick 151 controls the motion of guide wire 155 .
- the actuator conveys a corresponding train of pulses to modulator 153 .
- These pulses are synchronized via line 154 to the reference signal.
- the pulse train when delivered to the modulator, creates the forward motion of the guide wire in a synchronized stepwise manner.
- control stick 151 typically, the harder operator pushes control stick 151 , the more intense are the pulses, hence wire 155 will move forward at a higher pace. By pulling stick 151 backwards, the guide wire will move correspondingly backwards.
- the force feedback provided to control stick 151 is spring loaded.
- a force feedback that bears greater resemblance to the original force feedback of wire 155 is generated. For example, force feedback that does not vary with respect to the cyclic activity of the blood vessel, or force feedback that is smoothened with respect to the movement of the blood vessel, may be generated.
- the operator exerts force on guide wire 155 directly, and not indirectly via control stick 151 as is described above.
- the actuator provides custom force feedback which typically increases its user-friendliness by providing the operator with a more familiar feel.
- the actuator (and specifically the control stick) replicates the tactile feedback of specific medical tools, thus increasing its utility to the operator.
- a digital library of tool-specific force feedbacks is connected to the actuator.
- the force feedback specific to each tool is selected by the operator.
- the force feedback specific to each tool is selected automatically, with the actuator identifying the tool (such as via a specific code).
- the aforementioned actuator controls the application of:
- the aforementioned actuator comprises re-usable elements, restricted-reuse elements, single-use elements, or any combination thereof.
- the actuator, or elements thereof are usable only for a specific time period and/or a specific number of uses following their initial activation.
- the time period and/or number of uses are coded in a memory element (such as a memory chip) incorporated into the actuator.
- FIG. 16 is a schematic illustration of the stepwise transluminal placement of a coronary bypass graft 163 in a coronary blood vessel 161 in order to bypass an occlusion 162 , in accordance with an embodiment of the present invention.
- a coronary bypass graft 163 in a coronary blood vessel 161 in order to bypass an occlusion 162 , in accordance with an embodiment of the present invention.
- a bypass is implanted between the proximal and distal sides of a major impairment (such as a total occlusion) in a blood vessel.
- Embodiments of the current invention by providing a full or partial virtual stabilization as previously explained, make it possible to connect the proximal and distal sides of impairment 162 without open surgery.
- the two sides of the impairment are connected transluminally.
- images generated from two separate views sequentially or concurrently (such as those provided concurrently by a bi-plane fluoroscopy system), are used. Such views typically differ from one another by at least 30 degrees, and in some embodiments they are perpendicular.
- the graft is a biological graft.
- the graft is a synthetic graft.
- the aforementioned modulator, modulator-accumulator and/or actuator are not hand held. In some embodiments, the aforementioned modulator, modulator-accumulator or actuator are connected to or operated by a medical robot. In some embodiments, the aforementioned modulator, modulator-accumulator and/or actuator are operated in a remote manner via a communications network (e.g., tele-operation).
- a communications network e.g., tele-operation
- the aforementioned techniques are applied to an organ that does not move cyclically, but is cyclically active (such as the brain).
- the synchronized tools disclosed by the current invention are connected to, or operated by, a medical robot.
- the scope of the present invention includes using the techniques of synchronized actuation of a tool, as described hereinabove, for applications other than those described in detail hereinabove.
- the techniques can be used in combination with the techniques described hereinabove, for stabilized imaging of a cyclically moving organ.
- movement of a tool in a given direction or along a desired pattern is synchronized with a physiological cycle.
- the tool is moved in the given direction at a given phase of respective physiological cycles without moving the tool in the opposite direction to the given direction, between movements of the tool in the given direction.
- a tool is moved in a given direction by moving the center of the tool.
- a tool is actuated either to perform a function, or to move.
- a tool is actuated to mechanically perform a function with respect to a portion of the subject's body that moves as a result of the cycle.
Abstract
Apparatus is described for use with a portion of a subject's body that moves as a result of cyclic activity of a body system. An imaging device acquires a plurality of image frames of the portion. A sensor senses a phase of the cyclic activity. A medical tool performs a function with respect to the portion. A control unit generates a stabilized set of image frames of the medical tool disposed within the portion, actuates the tool to perform the function or move, in response to the sensor sensing that the cyclic activity is at a given phase thereof, and inhibits the tool from performing the action or moving in response to the sensor sensing that the cyclic activity is not at the given phase. A display facilitates use of the tool by displaying the stabilized set of image frames. Other embodiments are also described.
Description
- The present patent application claims the benefit of U.S. Provisional Patent Application Nos. 60/906,091 filed on Mar. 8, 2007, 60/924,609 filed on May 22, 2007, 60/929,165 filed on Jun. 15, 2007, 60/935,914 filed on Sep. 6, 2007, and 60/996,746 filed on Dec. 4, 2007, all named “Apparatuses and methods for performing medical procedures on cyclically-moving body organs,” all of which applications are incorporated herein by reference.
- The present application is related to the following applications, which are incorporated herein by reference:
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- a U.S. patent application, entitled “Imaging for use with moving organs,” to Tolkowsky et al., which is filed on even date with the current application.
- a U.S. patent application, entitled “Tools for use with moving organs,” to Iddan et al., which is filed on even date with the current application.
- a PCT Application, entitled “Imaging and tools for use with moving organs,” to Iddan et al., filed on Mar. 9, 2008.
- The present invention generally relates to medical apparatus. Specifically, the present invention relates to stabilizing imaging of cyclically moving body portions and synchronizing the actuation and/or movement of tools with the cyclical motion of cyclically moving body portions.
- Continuous images of a cyclically-moving body organ are typically displayed in the course of many medical procedures such as procedures performed on the heart, the thorax, the respiratory tract, the eyes, or the cardiovascular system. Such images typically shift constantly and are also prone to blurring. Consequently, such images are typically difficult to observe, and are difficult to use in making clinical decisions over an extended period of time (such as the entire duration of the procedure).
- Many procedures are performed with respect to moving body parts, for example the insertion of balloons and stents into moving blood vessels. A difficulty associated with such procedures is the targeted deployment and/or actuation of tools with respect to the moving body part.
- U.S. Pat. No. 4,865,043 to Shimoni, which is incorporated herein by reference, describes a data selection method and system using a plurality of multi-dimensional windows wherein two parameters of ECG signals are tested for determining whether the imaging data received simultaneously with the ECG signal is to be accepted. The plurality of windows are described as providing a capability to gate and to sort imaging data based on the passage of associated ECG signals through each of the plurality of windows with different parameters. Thus images are described as being reconstructed for a population of abnormally short or long heart cycles from a common data pool.
- U.S. Pat. No. 3,954,098 to Dick et al., which is incorporated herein by reference, describes a scan converter storage surface which is divided into image spaces corresponding to different points in the heart cycle. Ultrasound echoes from heart structures are plotted in the image spaces by means of special x, y sweeps which are offset to the image spaces by timing circuitry.
- U.S. Pat. No. 4,382,184 to Wernikoff, which is incorporated herein by reference, describes X-ray apparatus and methods for producing discrete images of a human organ in fluctuating motion, e.g., the heart and related vessels. Each image is derived at a selected time related to the cardiac cycle. The images are independently presented on respective discrete areas within a common image plane. A source of X-rays irradiates the organ. A physiological synchronizer produces timing signals within the cardiac cycle for controlling the periods of transmission of the X-ray beam through the organ during, for example, end diastole and end systole. An anti-scattering, masking frame has alternate parallel slits and bars at equal intervals exposing substantially half the area of presentation of an X-ray sensitive film in alternate, equally spaced area strips during, e.g., diastole. The frame is repositioned in response to a signal from the synchronizer for actuating it relative to the film, such that the bars then cover the sensitized areas of the film and expose substantially the remaining half of the film during systole. The image elements are interdigitally juxtaposed to present the diastolic and systolic images in an interlaced pattern. Relative displacements of the organ during a cardiac cycle may be determined from the juxtaposed image elements.
- U.S. Pat. No. 4,016,871 to Schiff, which is incorporated herein by reference, describes a system which is capable of simultaneously displaying a plurality of waveforms on the face of a CRT which are representative of ECG, arterial pressures and operating states of the mechanical heart assistance devices, as well as a “timing bar” which sweeps across the CRT face in synchronism with the ECG trace, for example. Optical pickups are slidably mounted adjacent the CRT face across the path of the “timing bar” sweep for activating photodetectors which in turn initiate inflation and deflation of mechanical assistive devices at any desired point along the ECG or pressure trace. Any one of the pressure or ECG traces may be “frozen” on the display face to facilitate comparison between a trace of the condition of the heart prior to the use of heart assistance and a trace of the augmented condition. All traces may be freely moved to any location upon the display face so as to permit close positioning and even superimposition of two or more traces to still further facilitate visual comparisons. The timing bar may also be utilized to provide an electrical pacing assist for controlling patient heart rate as well as for extending the heart refractory period enabling the assistance devices to operate at reduced rates.
- U.S. Pat. No. 3,871,360 to Van Horn et al., which is incorporated herein by reference, describes a system for timing biological imaging, measuring, or therapeutic apparatus in accordance with selected physiological states of a subject, featuring in various aspects generation of respiratory windows on the basis of processed electrical signals derived from prior respiration history, digital offset correction circuitry for the respiratory signals, and generation of cardiac timing signals on the basis of prior cardiac cycle history.
- U.S. Pat. No. 4,031,884 to Henzel, which is incorporated herein by reference, describes apparatus for correlating the respiratory and cardiac cycles includes a circuit for defining a chosen period in the progress of the respiratory cycle as the end of a regulatable delay beginning when the ascending front of the inspiratorial pressure reaches a regulatable level as well as a circuit for defining a chosen period in the progress of the cardiac cycle as the end of a regulatable delay beginning when the differential dV/dt of the blood pressure reaches a regulatable level. An operator such as a terminal relay is activated upon the coincidence of these two periods in time after a regulatable delay and during a regulatable period.
- U.S. Pat. No. 4,994,965 to Crawford et al., which is incorporated herein by reference, describes a method of reducing image artifacts in tomographic, projection imaging systems due to periodic motion of the object being imaged, and includes the acquisition of a signal indicative of the periodic motion. This signal is used to identify a quiescent period in the periodic motion so that the acquisition of projection data may be coordinated to be centered within the quiescent period.
- U.S. Pat. No. 4,878,115 to Elion, which is incorporated herein by reference, describes a method in which a dynamic coronary roadmap of the coronary artery system is produced by recording and storing a visual image of the heart creating a mask sequence, recording and storing another dynamic visual image of the heart after injection of a contrast medium thereby creating a contrast sequence, matching the different durations of two sequences and subtracting the contrast sequence from the mask sequence producing a roadmap sequence. The roadmap sequence is then replayed and added to live fluoroscopic images of the beating heart. Replay of the roadmap sequence is triggered by receipt of an ECG R-wave. The result is described as a dynamically moving coronary roadmap image which moves in precise synchronization with the live incoming fluoroscopic image of the beating heart.
- U.S. Pat. No. 4,709,385 to Pfeiler, which is incorporated herein by reference, describes an x-ray diagnostics installation for subtraction angiography, which has an image memory connected to an output of an x-ray image intensifier video chain which has a number of addresses for storing individual x-ray video signals obtained during a dynamic body cycle of a patient under observation. A differencing unit receives stored signals from the image memory as well as current video signals and subtracts those signals to form a superimposed image. Entry and readout of signals to and from the image memory is under the command of a control unit which is connected to the patient through, for example, an EKG circuit for identifying selected occurrences in the body cycle under observation. Entry and readout of data from the image memory is thereby controlled in synchronization with the selected occurrences in the cycle.
- U.S. Pat. No. 4,270,143 to Morris, which is incorporated herein by reference, describes a cross-correlation video tracker and method for automatically tracking a relatively moving scene by storing elements from a frame of a video signal to establish a reference frame and comparing elements from a subsequent frame with the stored reference frame to derive signals indicating the direction and angular distance of scene relative movement. A cross-correlation difference signal is generated which represents the difference between a pair of cross-correlation signals dependent on the correlations of the subsequent frame elements and the stored reference elements at two predetermined opposite relative shifts. A circuit is responsive to this difference signal for generating an error signal indicative of the amount of shift required to center the stored reference frame with respect to the subsequent frame.
- U.S. Pat. No. 4,758,223 to Rydell, which is incorporated herein by reference, describes a hand-operated device for inflating the expander on a balloon-type catheter and for perfusing fluids through the catheter and out its distal end.
- U.S. Pat. No. 4,723,938 to Goodin et al., which is incorporated herein by reference, describes an inflation/deflation device for an angioplasty balloon catheter which permits quick inflation to an approximate working pressure followed by a fine but slower adjustment to a final desired pressure.
- U.S. Pat. No. 6,937,696 to Mostafavi, which is incorporated herein by reference, describes a method and system for physiological gating. A method and system for detecting and estimating regular cycles of physiological activity or movements is also disclosed. Another disclosed embodiment is directed to predictive actuation of gating system components. Yet another disclosed embodiment is directed to physiological gating of radiation treatment based upon the phase of the physiological activity. Gating can be performed, either prospectively or retrospectively, to any type of procedure, including radiation therapy or imaging, or to other types of medical devices and procedures such as PET, MRI, SPECT, and CT scans.
- U.S. Pat. No. 6,246,898 to Vesely et al., which is incorporated herein by reference, describes a method for carrying out a medical procedure using a 3-D tracking and imaging system. A surgical instrument, such as a catheter, probe, sensor, pacemaker lead, needle, or the like is inserted into a living being, and the position of the surgical instrument is tracked as it moves through a medium in a bodily structure. The location of the surgical instrument relative to its immediate surroundings is displayed to improve a physician's ability to precisely position the surgical instrument. The medical procedures including targeted drug delivery, sewing sutures, removal of an obstruction from the circulatory system, a biopsy, amniocentesis, brain surgery, measurement of cervical dilation, evaluation of knee stability, assessment of myocardial contractibility, eye surgery, prostate surgery, trans-myocardial revascularization (TMR), robotic surgery, and evaluation of RF transmissions.
- US Patent Application Publication 2006/0058647 to Strommer et al., which is incorporated herein by reference, describes a method for delivering a medical device coupled with a catheter, to a selected position within a lumen of the body of a patient, the method comprising the procedures of: registering a three-dimensional coordinate system with a two-dimensional coordinate system, the three-dimensional coordinate system being associated with a medical positioning system (MPS), the two-dimensional coordinate system being associated with a two-dimensional image of the lumen, the two-dimensional image being further associated with an organ timing signal of an organ of the patient; acquiring MPS data respective of a plurality of points within the lumen, each of the points being associated with the three-dimensional coordinate system, each of the points being further associated with a respective activity state of the organ; determining a temporal three-dimensional trajectory representation for each of the respective activity states from the acquired MPS data which is associated with the respective activity state; superimposing the temporal three-dimensional trajectory representations on the two-dimensional image, according to the respective activity state; receiving position data respective of the selected position, by selecting at least one of the points along the temporal three-dimensional trajectory representation; determining the coordinates of the selected position in the three-dimensional coordinate system, from the selected at least one point; determining the current position of the medical device in the three-dimensional coordinate system, according to an output of an MPS sensor attached to the catheter in the vicinity of the medical device; maneuvering the medical device through the lumen, toward the selected position, according to the current position relative to the selected position; and producing a notification output when the current position substantially matches the selected position.
- U.S. Pat. No. 6,666,863 to Wentzel et al., which is incorporated herein by reference, describes devices and methods for performing percutaneous myocardial revascularization (PMR). An embodiment is described in which a detector of an ablation controller provides a detect signal when a sensor block output signal indicates that a first electrode is touching the wall of the heart. The ablation controller may also provide a detect signal when the heart is in a less vulnerable portion of the cardiac rhythm, such as when the ventricles of the heart are contracting. As such, the ablation controller is described as helping to identify when the first electrode is in contact with the wall of the heart, thereby reducing the likelihood that an ablation will be triggered when the first electrode is not in contact with the endocardium of the heart and cause damage to the blood platelets within the heart.
- U.S. Pat. No. 5,176,619 to Segalowitz, which is incorporated herein by reference, describes a heart-assist device which includes a flexible catheter carrying at least a ventricular balloon, such balloon corresponding in size and shape to the size and shape of the left ventricle in the heart being assisted, the ventricular balloon being progressively inflated creating a wave-like pushing effect and deflated synchronously and automatically by means of a control console which responds to heart signals from the catheter or elsewhere.
- PCT Publication WO 94/010904 to Nardella, which is incorporated herein by reference, describes an ablation catheter that has an ablation electrode at a distal end coupled to an ablation power source through a low impedance coupling. In some embodiments, ablation only occurs while the heart is in a desired part of the cardiac cycle, the ablation power intervals being triggered by timing pulses synchronized with detection of the R wave. This mode of actuation is described as assuring that the heart is essentially stationary before delivery of ablation energy, thus minimizing the risk of inadvertently ablating healthy tissue.
- An article by Boyle et al., entitled “Assessment of a Novel Angiographic Image Stabilization System for Percutaneous Coronary Intervention” (Journal of Interventional Cardiology,” Vol. 20 No. 2, 2007), which is incorporated herein by reference, describes a system for stabilizing angiographic images at a region of interest in order to assist during percutaneous coronary intervention (PCI).
- An article by Timinger et al., entitled “Motion compensated coronary interventional navigation by means of diaphragm tracking and elastic motion models” (Phys Med Biol. 2005 Feb. 7; 50(3):491-503), which is incorporated herein by reference, presents a method for compensating the location of an interventional device measured by a magnetic tracking system for organ motion and thus registering it dynamically to a 3D virtual roadmap. The motion compensation is accomplished by using an elastic motion model which is driven by the ECG signal and a respiratory sensor signal derived from ultrasonic diaphragm tracking.
- An article by Timinger et al., entitled “Motion compensation for interventional navigation on 3D static roadmaps based on an affine model and gating” (Phys Med Biol. 2004 Mar. 7; 49(5):719-32), which is incorporated herein by reference, describes a method for enabling cardiac interventional navigation on motion-compensated 3D static roadmaps.
- An article by Turski et al., entitled “Digital Subtraction Angiography ‘Road Map’” (American Journal of Roentgenology, 1982), which is incorporated herein by reference, describes a technique called roadmapping. An arterial roadmap for the subsequent manipulation of catheters under fluoroscopy is generated by means of first injecting a contrast agent into said arteries and using the resulting, “highlighted” arterial image as a background to the real-time fluoroscopic imaging of the catheterization procedure.
- An article by Iddan et al., entitled “3D imaging in the studio and elsewhere” (SPIE Proceedings Vol. 4298 2001), which is incorporated herein by reference, describes the technique of background subtraction and replacement of video images, which has been used in TV studios.
- The following patents and patent applications, which are incorporated herein by reference, may be of interest:
- U.S. Pat. No. 5,830,222 to Makower
- U.S. Pat. No. 4,245,647 to Randall
- U.S. Pat. No. 4,316,218 to Gay
- U.S. Pat. No. 4,849,906 to Chodos et al.
- U.S. Pat. No. 5,062,056 to Lo et al.
- U.S. Pat. No. 5,630,414 to Horbaschek
- U.S. Pat. No. 6,442,415 to Bis et al.
- U.S. Pat. No. 6,473,635 to Rasche
- U.S. Pat. No. 4,920,413 to Nakamura
- U.S. Pat. No. 6,233,478 to Liu
- U.S. Pat. No. 5,764,723 to Weinberger
- U.S. Pat. No. 5,619,995 to Lobodzinski
- U.S. Pat. No. 4,991,589 to Hongo et al.
- U.S. Pat. No. 5,538,494 to Matsuda
- U.S. Pat. No. 5,020,516 to Biondi
- U.S. Pat. No. 7,209,779 to Kaufman
- U.S. Pat. No. 6,858,003 to Evans et al.
- U.S. Pat. No. 6,786,896 to Madhani et al.
- U.S. Pat. No. 6,999,852 to Green
- U.S. Pat. No. 7,155,315 to Niemeyer et al.
- U.S. Pat. No. 5,971,976 to Wang et al.
- U.S. Pat. No. 6,377,011 to Ben-Ur
- U.S. Pat. No. 6,711,436 to Duhaylongsod
- U.S. Pat. No. 7,269,457 to Shafer
- U.S. Pat. No. 6,959,266 to Mostafavi
- U.S. Pat. No. 7,191,100 to Mostafavi
- U.S. Pat. No. 6,708,052 to Mao et al.
- U.S. Pat. No. 7,180,976 to Wink et al.
- U.S. Pat. No. 7,085,342 to Younis et al.
- U.S. Pat. No. 6,731,973 to Voith
- U.S. Pat. No. 6,728,566 to Subramanyan
- U.S. Pat. No. 5,766,208 to McEwan
- U.S. Pat. No. 6,704,593 to Stainsby
- U.S. Pat. No. 6,973,202 to Mostafavi
- US Patent Application Publication 2007/0173861 to Strommer
- US Patent Application Publication 2007/0208388 to Jahns
- US Patent Application Publication 2007/0219630 to Chu
- US Patent Application Publication 2004/0176681 to Mao et al.
- US Patent Application Publication 2005/0090737 to Burrel et al.
- US Patent Application Publication 2006/0287595 to Maschke
- US Patent Application Publication 2007/0142907 to Moaddeb et al.
- US Patent Application Publication 2007/0106146 to Altmann et al.
- US Patent Application Publication 2005/0054916 to Mostafavi
- US Patent Application Publication 2003/0018251 to Solomon
- US Patent Application Publication 2002/0049375 to Strommer et al.
- US Patent Application Publication 2005/0137661 to Sra
- US Patent Application Publication 2005/0143777 to Sra
- US Patent Application Publication 2004/0077941 to Reddy et al.
- PCT Publication WO 06/066122 to Sra
- PCT Publication WO 06/066124 to Sra
- PCT Publication WO 05/02689.1 to Mostafavi
- PCT Publication WO 01/43642 to Heuscher
- PCT Publication WO 03/096894 to Ho et al.
- PCT Publication WO 05/124689 to Manzke
- The following articles, which are incorporated herein by reference, may be of interest:
- “Catheter Insertion Simulation with Combined Visual and Haptic Feedback,” by Zorcolo et al. (Center for Advanced Studies, Research and Development in Sardinia)
- “New 4-D imaging for real-time intraoperative MRI: adaptive 4-D scan,” by Tokuda et al. (Med Image Comput Assist Interv Int Conf. 2006; 9(Pt 1):454-61)
- “Real-time interactive viewing of 4D kinematic MR joint studies,” by Schulz et al. (Med Image Comput Assist Interv Int Conf. 2005; 8(Pt 1):467-73.)
- “Prospective motion correction of X-ray images for coronary interventions,” by Shechter et al. (IEEE Trans Med Imaging. 2005 April; 24(4):441-50)
- “Cardiac Imaging: We Got the Beat!” by Elizabeth Morgan (Medical Imaging, March 2005)
- “Noninvasive Coronary Angiography by Retrospectively ECG-Gated Multislice Spiral CT,” by Achenbach et al., (Circulation. 2000 Dec. 5; 102(23):2823-8)
- “Full-scale clinical implementation of a video based respiratory gating system,” by Ramsey et al., (Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE, 2000, Volume: 3, 2141-2144)
- “Spatially-adaptive temporal smoothing for reconstruction of dynamic and gated image sequences,” by Brankov et al., (Nuclear Science Symposium Conference Record, 2000 IEEE, 2000, Volume: 2, 15/146-15/150)
- “4D smoothing of gated SPECT images using a left-ventricle shape model and a deformable mesh,” by Brankov et al., (Nuclear Science Symposium Conference Record, 2004 IEEE, October 2004, Volume: 5, 2845-2848)
- “4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT Tinsu Pan,” by Lee et al., (Medical Physics, February 2004,
Volume 31,Issue 2, pp. 333-340) - “Three-Dimensional Respiratory-Gated MR Angiography of the Coronary Arteries: Comparison with Conventional Coronary Angiography,” by Post et al., (AJR, 1996; 166: 1399-1404)
- In some embodiments of the invention, apparatus and methods are used for facilitating medical procedures performed on cyclically-moving organs, so that such procedures are performed under a partial or full virtual stabilization of such organs. In some embodiments, the stabilization comprises at least one of the following elements: the stabilization of image(s) being viewed with respect to the motion of an organ, and the actuation of tool(s) applied to the organ in synchronization with the organ's motion.
- In some embodiments, continuously-generated image frames of cyclically-moving organs are gated to one or more physiological signals or processes, wherein the cycle(s) of such signals or processes correspond to a motion cycle of the organ being imaged. Consequently, the displayed gated image frames of the organ are typically all in a selected same phase of a motion cycle of the organ.
- In some embodiments, the gated images are displayed with a smoothened transition filling the gaps among them, generating a synthesized, continuous video stream.
- In some embodiments, image tracking is applied to continuously-generated images of moving organs, to align such images to one another. The motion to which such tracking is applied may be cyclical, or non-cyclical, or a combination of both. The visual effect of such motion is typically reduced by the image tracking.
- In some embodiments, a combination of the aforementioned gating, tracking and/or gap filling are applied to generate a stabilized image stream.
- In some embodiments, road mapping is applied to the stabilized image stream. In some embodiments, roadmapping is applied to the stabilized image stream to facilitate a medical procedure that is performed on the moving organ.
- In some embodiments, the actuation or movement of one or more medical tools applied to a cyclically-moving organ is synchronized with one or more physiological signals or processes whose cycle(s) corresponds to a motion cycle of the organ. Consequently, the tool is typically actuated only during one or more selected same phases in a motion cycle of the organ. In some embodiments, the synchronized actuation of medical tools controls the application of linear motion, angular motion, energy, substance delivery, or any combination thereof.
- In some embodiments, the aforementioned stabilized imaging and synchronized tool application are applied jointly to a cyclically moving organ. In some embodiments, images of the organ are stabilized with respect to a given phase of the cycle, and the actuation of the tool is synchronized to the same phase. In some embodiments, this leads to virtual stabilization of the cyclically-moving organ, both with respect to the imaging of the organ and the tools being moved and/or applied.
- It is noted, however, that the scope of the present invention includes synchronized tool application and/or movement with respect to a cyclically moving organ, using techniques described herein, even in the absence of stabilized imaging as described herein, or even in the absence of any imaging.
- In some embodiments, the aforementioned techniques are applied to an organ that may not be cyclically moving, but is cyclically active, for example, an organ that undergoes neural cyclic activity.
- There is therefore provided, in accordance with an embodiment of the invention, apparatus for imaging a portion of a body of a subject that moves as a result of cyclic activity of a first body system of the subject and that also undergoes additional motion, the apparatus including:
- an imaging device for acquiring a plurality of image frames of the portion of the subject's body;
- a sensor for sensing a phase of the cyclic activity of the first body system;
- a control unit configured to generate a stabilized set of image frames of the portion of the subject's body:
-
- by identifying a given phase of the cyclic activity of the first body system, and outputting a set of the image frames corresponding to image frames of the portion acquired during the given phase, and
- by image tracking at least the set of image frames to reduce imaged motion of the portion of the subject's body associated with the additional motion; and
- a display configured to display the stabilized set of image frames of the portion of the subject's body.
- In an embodiment, the control unit is configured to identify the given phase of the cyclic activity using a gating signal, and the display is configured to display a representation of the gating signal simultaneously with displaying the stabilized set of image frames.
- In an embodiment, the display is configured to display an enlarged stabilized set of image frames of a region within the portion of the subject's body.
- In an embodiment, to generate the stabilized set of image frames of the portion of the subject's body, the control unit is configured:
- to identify a first image frame acquired during the given phase,
- subsequently, to image track the first identified image frame,
- subsequently, to identify a second image frame acquired during the given phase, and
- subsequently, to image track the second identified image frame.
- In an embodiment, to generate the stabilized set of image frames of the portion of the subject's body, the control unit is configured:
- to image track a first image frame,
- subsequently, to place the first image tracked frame in the stabilized set of image frames if the first image tracked frame was acquired during the given phase,
- subsequently to image track a second image frame, and
- subsequently, to place the second image tracked frame in the stabilized set of image frames if the second image tracked frame was acquired during the given phase.
- In an embodiment, to generate the stabilized set of image frames of the portion of the subject's body, the control unit is configured:
- to generate a gated set of image frames of the plurality of image frames corresponding to image frames of the portion acquired during the given phase, and
- subsequently, to image track the gated set of image frames.
- In an embodiment, to generate the stabilized set of image frames of the portion of the subject's body, the control unit is configured:
- to image track the plurality of image frames of the portion of the subject's body, and
- subsequently, to generate a set of image frames corresponding to those of the tracked image frames of the portion that were acquired during the given phase.
- In an embodiment, the control unit includes a video tracker selected from the group consisting of: an edge tracker, a centroid tracker, a correlation tracker, and an object tracker, and the control unit is configured to image track the at least the set of image frames using the selected video tracker.
- In an embodiment, the control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase by controlling the imaging device to acquire the plurality of image frames only when the cyclic activity is at the given phase.
- In an embodiment,
- the imaging device is configured to acquire the plurality of image frames throughout the cyclic activity, and
- the control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase, by selecting image frames corresponding to image frames of the portion acquired during the given phase from the plurality of image frames.
- In an embodiment, the apparatus further includes a user interface, and the control unit is configured to receive an input from a user, via the user interface, and to select a phase of the cyclic activity as being the given phase in response to the input.
- In an embodiment, the display is configured to display the plurality of acquired image frames simultaneously with displaying the stabilized set of image frames.
- In an embodiment, the apparatus is configured for the display to display the stabilized set of image frames in real time with respect to the acquisition of the plurality of image frames by the imaging device.
- In an embodiment, the apparatus is configured for the display to display the stabilized set of image frames within 4 seconds of the imaging device having imaged the plurality of image frames.
- In an embodiment, the apparatus is configured for the display to display the stabilized set of image frames less than two cycles of the cyclic activity after the imaging device imaged the plurality of image frames.
- In an embodiment, the apparatus is configured for the display to display the stabilized set of image frames during a medical procedure during which the imaging device images the plurality of image frames.
- In an embodiment, the apparatus is configured to display the stabilized set of image frames subsequent to a medical procedure during which the imaging device imaged the plurality of image frames.
- In an embodiment, the apparatus further includes a data storage unit configured to store the stabilized set of image frames.
- In an embodiment, the control unit is configured to enhance the stabilized set of image frames by image processing the stabilized set of image frames.
- In an embodiment, the additional motion is not associated with cyclic activity of the subject's body, and the control unit is configured to reduce the imaged motion associated with the additional motion that is not associated with cyclic activity, by image tracking at least the set of image frames.
- In an embodiment, the additional motion is associated with whole-body motion of the subject, and the control unit is configured to reduce the imaged motion associated with the whole-body motion by image tracking at least the set of image frames.
- In an embodiment, the apparatus further includes:
- a contrast agent; and
- an injection tool configured to inject the contrast agent into a space within the portion of the subject's body, and
-
- the imaging device is configured to acquire at least one image frame of the space during the given phase, at a time when at least some of the contrast agent is present within the space, and
- the display is configured to display the at least one image frame of the space overlaid on at least one same one of the stabilized set of image frames.
- In an embodiment,
- the imaging device is configured to acquire a first image frame of the space during the given phase of a first cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the space,
- the imaging device is configured to acquire a second image frame of the space during the given phase of a second cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the space, and
- the display is configured to display the first and the second image frame of the space overlaid on at least one same frame of the stabilized set of image frames.
- In an embodiment,
- the space includes a lumen containing an occlusion,
- the injection tool is configured to inject the contrast agent into the lumen on a proximal side of the occlusion and on a distal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the proximal side of the occlusion during the given phase of a cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the proximal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the distal side of the occlusion during the given phase of the cycle, at a time when at least some of the contrast agent is present within the lumen on the distal side of the occlusion, and
- the display is configured to display the at least one image frame of the lumen on the proximal side of the occlusion and the at least one image frame of the lumen on the distal side of the occlusion overlaid on at least one same frame of the stabilized set of image frames.
- In an embodiment,
- the space includes a lumen containing an occlusion,
- the injection tool is configured to inject the contrast agent into the lumen on a proximal side of the occlusion and on a distal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the proximal side of the occlusion during the given phase of a first cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the proximal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the distal side of the occlusion during the given phase of a second cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the distal side of the occlusion, and
- the display is configured to display the at least one image frame of the lumen on the proximal side of the occlusion and the at least one image frame of the lumen on the distal side of the occlusion overlaid on at least one same frame of the stabilized set of image frames.
- In an embodiment,
- the space includes a lumen containing an occlusion,
- the injection tool is configured to inject the contrast agent into the lumen on a proximal side of the occlusion,
- the apparatus further includes a second injection tool configured to inject the contrast agent into the lumen on a distal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the proximal side of the occlusion during the given phase of a cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the proximal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the distal side of the occlusion during the given phase of the cycle, at a time when at least some of the contrast agent is present within the lumen on the distal side of the occlusion, and
- the display is configured to display the at least one image frame of the lumen on the proximal side of the occlusion and the at least one image frame of the lumen on the distal side of the occlusion overlaid on at least one same frame of the stabilized set of image frames.
- In an embodiment,
- the space includes a lumen containing an occlusion,
- the injection tool is configured to inject the contrast agent into the lumen on a proximal side of the occlusion,
- the apparatus further includes a second injection tool configured to inject the contrast agent into the lumen on a distal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the proximal side of the occlusion during the given phase of a first cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the proximal side of the occlusion,
- the imaging device is configured to acquire at least one image frame of the lumen on the distal side of the occlusion during the given phase of a second cycle of the cyclic activity, at a time when at least some of the contrast agent is present within the lumen on the distal side of the occlusion, and
- the display is configured to display the at least one image frame of the lumen on the proximal side of the occlusion and the at least one image frame of the lumen on the distal side of the occlusion overlaid on at least one same frame of the stabilized set of image frames.
- In an embodiment, the imaging device includes a fluoroscope.
- In an embodiment, the space includes a space selected from the group consisting of a chamber of a heart of the subject, a lumen of a coronary blood vessel of the subject, and a lumen of an aorta of the subject, and the injection tool is configured to inject the contrast agent into the selected space.
- In an embodiment, the control unit is configured to construct at least one three-dimensional image frame of the space, during the given phase, based on image frames acquired at the time when at least some of the contrast agent is present within the space.
- In an embodiment, the apparatus further includes a medical tool configured to be inserted into the space, the apparatus is configured to acquire an image of the tool while the tool is inside the space, and the display is configured to display the image of the tool overlaid on the image frame of the space.
- In an embodiment, the control unit is configured to identify when the injection tool injects the contrast agent by image processing a set of image frames of the space.
- In an embodiment, the control unit is configured to identify when the injection tool injects the contrast agent by specifically analyzing a region of at least some of the plurality of image frames that corresponds to a vicinity of a distal tip of the injection tool.
- In an embodiment, the control unit is configured to identify when the injection tool injects the contrast agent by determining a level of darkness of the region of at least some of the plurality of image frames that corresponds to the vicinity of the distal tip of the injection tool.
- In an embodiment, the apparatus further includes a user interface, and the display is configured to receive an input from a user, via the user interface, and to display a marking at a given position within the portion of the subject's body within the stabilized set of image frames, in response to the input.
- In an embodiment, the display is configured to display two or more views of the stabilized set of image frames of the portion of the subject's body, and to display the marking at the given position within respective views of the stabilized set of image frames.
- In an embodiment, the imaging device is further configured to image a plurality of images of a medical tool disposed within the portion of the subject's body, and the control unit is configured to generate a stabilized set of image frames of the medical tool.
- In an embodiment, the medical tool includes a medical tool that is implanted within the portion of the subject's body, and the imaging device is configured to image a plurality of images of the implanted medical tool.
- In an embodiment, the medical tool includes a medical tool that is transiently inserted within the portion of the subject's body, and the imaging device is configured to image a plurality of images of the medical tool while it is inserted within the portion.
- In an embodiment, the control unit is configured to enhance the stabilized set of image frames of the medical tool by image processing the stabilized set of image frames of the medical tool.
- In an embodiment, the control unit is configured to determine a physiological parameter of the subject by analyzing the stabilized set of image frames.
- In an embodiment, the control unit is configured to determine a parameter relating to cardiac function of the subject by analyzing the stabilized set of image frames.
- In an embodiment, the control unit is configured to determine a parameter relating to respiratory function of the subject by analyzing the stabilized set of image frames.
- In an embodiment, in generating the stabilized set of image frames, the control unit is configured to smoothen a transition between successive frames of the set of frames.
- In an embodiment, the control unit is configured to smoothen the transition between the successive frames, by:
- determining a characteristic of motion of an object within the stabilized set of image frames by image processing frames of the stabilized set of image frames,
- generating a simulated image of the object by assuming that the object continues to move according to the determined profile, and
- using the simulated image of the object as an intermediate image between successive image frames.
- In an embodiment, the control unit is configured to smoothen the transition between the successive frames, by:
- determining a position of an object within a non-gated image frame that was acquired subsequent to a first gated image frame and before a second gated image frame, and
- generating a representation of the object within the stabilized set of image frames before the second gated image frame is generated within the stabilized set of image frames.
- In an embodiment, the control unit is configured to determine a dimension of a region within the portion of the subject's body, by analyzing the stabilized set of image frames.
- In an embodiment, the control unit is configured to output an indication of a size of a medical tool relative to the region within the portion of the subject's body.
- In an embodiment,
- the apparatus further includes a medical tool configured to be inserted into the portion of the subject's body and having a known dimension, and the control unit is configured to determine the dimension of the region by comparing a dimension of the tool within the stabilized set of image frames to the known dimension.
- In an embodiment, the medical tool includes markers, the markers being separated from each other by a known distance, and the control unit is configured to determine an orientation at which the medical tool is disposed within the portion of the subject's body by determining a distance between the markers as viewed within the stabilized set of image frames with respect to the known distance.
- In an embodiment, the control unit is configured to generate a simulated image of a virtual medical tool disposed at the orientation within the stabilized set of image frames of the portion of the subject's body, in response to the determining of the distance.
- In an embodiment, the apparatus further includes a user interface, and the control unit is configured to receive an input from a user, via the user interface, and to generate a simulated image of a virtual medical tool disposed within the stabilized set of image frames of the portion of the subject's body, in response to receiving the input.
- In an embodiment, the control unit is configured to output dimensions of a real medical tool that corresponds to the simulated image of the virtual medical tool.
- In an embodiment, the control unit is configured to output the dimensions of the real medical tool by accounting for an orientation at which the virtual medical tool is disposed within the simulated image.
- In an embodiment, the control unit is configured to output the dimensions of the real medical tool by accounting for a curvature of a region of the portion of the subject's body within which region the virtual medical tool is disposed within the simulated image.
- In an embodiment, the control unit is configured to receive a first and a second input from the user and to generate respective simulated images of first and second medical tools being placed within the stabilized set of image frames of the portion of the subject's body, in response to receiving the inputs.
- In an embodiment, the imaging device includes two or more imaging devices, and the control unit is configured to generate two or more stabilized sets of image frames of the portion of the subject's body, the sets of image frames having been imaged by respective imaging devices of the two or more imaging devices.
- In an embodiment, a first imaging device of the two or more imaging devices is configured to image the portion of the subject's body before a medical procedure, a second imaging device of the two or more imaging devices is configured to image the portion of the subject's body during the medical procedure, and the control unit is configured to generate the stabilized sets of image frames during the medical procedure.
- In an embodiment, a first imaging device of the two or more imaging devices is configured to image the portion of the subject's body from outside the portion of the subject's body, and a second imaging device of the two or more imaging devices is configured to image regions within the portion of the subject's body while the second imaging device is disposed at respective locations within the portion of the subject's body.
- In an embodiment, the control unit is configured to associate (a) locations within the stabilized image frames acquired by the first imaging device that correspond to the respective locations of the second imaging device, with (b) respective image frames acquired by the second imaging device while the second imaging device was disposed at the respective locations.
- In an embodiment, the apparatus further includes a medical tool configured to be inserted into the portion of the subject's body to a vicinity of the respective locations while the second imaging device is not disposed at the respective locations, and the control unit is configured to generate (a) respective image frames acquired by the second imaging device while the second imaging device was disposed at the respective locations, when (b) the medical tool is disposed in a vicinity of the respective locations.
- In an embodiment, the first imaging device includes a fluoroscope and the second imaging device includes an intravascular ultrasound probe.
- In an embodiment, the first imaging device includes a CT scanner and the second imaging device includes an intravascular ultrasound probe.
- In an embodiment, the first imaging device is configured to acquire the plurality of image frames before the second imaging device images the regions within the portion of the subject's body.
- In an embodiment, the first imaging device is configured to acquire the plurality of image frames while the second imaging device images the regions within the portion of the subject's body, and the first imaging device is configured to acquire the plurality of image frames by acquiring a plurality of image frames of the second imaging device disposed within the portion.
- In an embodiment,
- the stabilized set of image frames defines a first stabilized set of image frames, and
- the control unit is configured to generate an additional stabilized set of image frames of the portion of the subject's body,
-
- by identifying a further given phase of the cyclic activity of the first body system, and generating an additional set of the image frames corresponding to image frames of the portion acquired during the further given phase, and
- by image tracking at least some of the additional set of image frames to reduce imaged motion of the portion of the subject's body associated with the additional motion.
- In an embodiment, the given phase includes a systolic phase of a cardiac cycle of the subject and the further given phase includes a diastolic phase of the subject's cardiac cycle, and the control unit is configured to generate sets of image frames which are stabilized respectively to the systolic and to the diastolic phases of the subject's cardiac cycle.
- In an embodiment, the apparatus further includes a user interface, and the control unit is configured to receive an input from a user, via the user interface, and to generate simulated images of a virtual medical tool disposed within the stabilized sets of image frames of the portion of the subject's body at the given phase and at the further given phase, in response to receiving the input.
- In an embodiment, the apparatus further includes a medical tool disposed within the portion of the subject's body, and the control unit is configured to generate stabilized images of the medical tool disposed within the portion of the subject's body respectively at the given phase and at the further given phase.
- In an embodiment, the control unit is configured to determine a physiological parameter of the subject by comparing the additional stabilized set of image frames to the first stabilized set of image frames.
- In an embodiment, the control unit is configured to determine a parameter relating to cardiac function of the subject by comparing the additional stabilized set of image frames to the first stabilized set of image frames.
- In an embodiment, the control unit is configured to determine a parameter relating to respiratory function of the subject by comparing the additional stabilized set of image frames to the first stabilized set of image frames.
- In an embodiment, the cyclic activity includes a cardiac cycle of the subject, and the sensor includes a sensor for sensing a phase of the subject's cardiac cycle.
- In an embodiment, the given phase includes an end-diastolic phase of the subject's cardiac cycle, and the control unit is configured to generate a stabilized set of the image frames corresponding to image frames of the portion acquired during the end-diastolic phase of the subject's cardiac cycle.
- In an embodiment, the sensor includes a blood pressure sensor.
- In an embodiment, the sensor includes an ECG sensor.
- In an embodiment, the sensor includes an image processor configured to sense a phase of the subject's cardiac cycle by comparing image frames of the plurality of image frames to at least one of the image frames of the plurality of image frames.
- In an embodiment, the cyclic activity includes a respiratory cycle of the subject, and the sensor includes a sensor for sensing a phase of the subject's respiratory cycle.
- In an embodiment, the sensor includes an image processor configured to sense a phase of the subject's respiratory cycle by comparing image frames of the plurality of image frames to at least one of the image frames of the plurality of image frames.
- In an embodiment, the additional motion is a result of cyclic activity of a second body system of the subject, and the control unit is configured to reduce imaged motion of the portion of the subject's body associated with the cyclic activity of the second body system by image tracking at least the set of image frames.
- In an embodiment,
- the cyclic activity of the first body system has a greater frequency than the cyclic activity of the second body system, and
- the control unit is configured to generate the stabilized set of image frames of the portion of the subject's body:
-
- by identifying the given phase of the cyclic activity of the first body system, and outputting the set of the image frames corresponding to image frames of the portion acquired during the given phase, and
- by image tracking at least the set of image frames to reduce imaged motion of the portion of the subject's body associated with the cyclic activity of the second body system.
- In an embodiment,
- the cyclic activity of the first body system has a lower frequency than a frequency of the cyclic activity of the second body system, and
- the control unit is configured to generate the stabilized set of image frames of the portion of the subject's body:
-
- by identifying the given phase of the cyclic activity of the first body system, and outputting the set of the image frames corresponding to image frames of the portion acquired during the given phase, and
- by image tracking at least the set of image frames to reduce imaged motion of the portion of the subject's body associated with the cyclic activity of the second body system.
- In an embodiment,
- the cyclic activity of the first body system includes a cardiac cycle of the subject,
- the cyclic activity of the second body system includes a respiratory cycle of the subject, and
- the control unit is configured to generate the stabilized set of image frames of the portion of the subject's body:
-
- by identifying the given phase of the cardiac cycle, and outputting the set of the image frames corresponding to image frames of the portion acquired during the given phase, and
- by image tracking at least the set of image frames to reduce imaged motion of the portion of the subject's body associated with the respiratory cycle.
- In an embodiment,
- the cyclic activity of the first body system includes a respiratory cycle of the subject,
- the cyclic activity of the second body system includes a cardiac cycle of the subject, and
- the control unit is configured to generate the stabilized set of image frames of the portion of the subject's body:
-
- by identifying the given phase of the respiratory cycle, and outputting the set of the image frames corresponding to image frames of the portion acquired during the given phase, and
- by image tracking at least the set of image frames to reduce imaged motion of the portion of the subject's body associated with the cardiac cycle.
- There is additionally provided, in accordance with an embodiment of the invention, apparatus for imaging a portion of a body of a subject that moves as a result of cyclic activity of a first body system of the subject and that also undergoes additional motion, and for use with an imaging device for acquiring a plurality of image frames of the portion of the subject's body, a sensor for sensing a phase of the cyclic activity of the first body system, and a display configured to display image frames of the portion of the subject's body, the apparatus including:
- a control unit configured to generate a stabilized set of image frames of the portion of the subject's body:
-
- by identifying a given phase of the cyclic activity of the first body system, and outputting a set of the image frames corresponding to image frames of the portion acquired during the given phase,
- by image tracking at least the set of image frames to reduce imaged motion of the portion of the subject's body associated with the additional motion,
- wherein the control unit is configured to output the stabilized set of image frames to be displayed on the display.
- There is further provided, in accordance with an embodiment of the invention, apparatus for imaging a portion of a body of a subject that moves as a result of cardiac cyclic activity of the subject and that also undergoes additional motion that is at least partially a result of a respiratory cycle of the subject, the apparatus including:
- an imaging device for acquiring a plurality of image frames of the portion of the subject's body;
- a sensor for sensing a phase of the cardiac cyclic activity;
- a control unit configured to generate a stabilized set of image frames of the portion of the subject's body:
-
- by identifying a given phase of the cardiac cyclic activity, and outputting a set of the image frames corresponding to image frames of the portion acquired during the given phase, and
- by image tracking at least the set of image frames to reduce imaged motion of the portion of the subject's body associated with the additional motion; and
- a display configured to display the stabilized set of image frames of the portion of the subject's body.
- There is additionally provided, in accordance with an embodiment of the invention, apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- a sensor for sensing a phase of the cyclic activity;
- a medical tool configured to perform a function with respect to the portion of the subject's body; and
- a control unit configured:
-
- in a first cycle of the cyclic activity, to move at least a portion of the tool in a given direction, in response to the sensor sensing that the cyclic activity is at a first given phase thereof,
- following the given phase in the first cycle and prior to an occurrence of the given phase in a subsequent cycle of the cyclic activity, to inhibit the movement of the at least a portion of the tool, and
- in a second cycle of the cyclic activity, subsequent to the inhibiting of the movement, to move the at least a portion of the tool in the given direction, in response to the sensor sensing that the second cycle of the cyclic activity is at the given phase thereof,
- without moving the at least a portion of the tool in a direction opposite to the given direction, between (a) moving the at least a portion of the tool in the given direction in the first cycle, and (b) moving the at least a portion of the tool in the given direction in the second cycle.
- In an embodiment, the control unit is configured to move a center of the tool by moving the portion of the tool in the given direction.
- In an embodiment, the tool includes a tool configured to be controlled remotely by a user.
- In an embodiment, the control unit is configured to be reversibly coupled to the tool.
- In an embodiment, the control unit is integrated into the tool.
- In an embodiment, the tool includes a guidewire configured to be moved within the portion of the subject's body.
- In an embodiment, the tool is configured to penetrate an occlusion of a lumen of the portion of the subject's body by being advanced through the lumen.
- In an embodiment, the tool includes a valve configured to be implanted within the portion of the subject's body by being expanded within the portion, and the control unit is configured to move at least a portion of the valve in the given direction, by moving the at least the portion of the valve in an expansion-related direction.
- In an embodiment, the tool includes a septal-closure device configured to be implanted within the portion of the subject's body by being expanded within the portion, and the control unit is configured to move at least a portion of the septal-closure device in the given direction, by moving the at least the portion of the septal-closure device in an expansion-related direction.
- In an embodiment, the cyclic activity includes a respiratory cycle of the subject, and the sensor is configured to sense a phase of the respiratory cycle.
- In an embodiment, the sensor includes an image processor configured to sense a phase of the subject's respiratory cycle by comparing image frames of a plurality of image frames of the portion of the subject's body to at least one of the image frames of the plurality of image frames.
- In an embodiment, the cyclic activity includes a cardiac cycle of the subject, and the sensor is configured to sense a phase of the cardiac cycle.
- In an embodiment, the sensor includes a blood pressure sensor.
- In an embodiment, the sensor includes an image processor configured to sense a phase of the subject's cardiac cycle, by comparing image frames of the plurality of image frames to at least one of the image frames of the plurality of image frames.
- In an embodiment, the sensor includes an ECG sensor configured to sense a phase of the cardiac cycle by detecting an ECG signal of the subject.
- In an embodiment, the tool includes a balloon configured to be inflated inside a lumen of the portion of the subject's body, and the control unit is configured to move at least a portion of the balloon in the given direction, by moving a surface of the balloon in an inflation-related direction.
- In an embodiment, the control unit is configured to inflate the balloon continuously for a period of time prior to the first cycle of the cyclic activity.
- In an embodiment, the control unit is configured to inflate the balloon continuously for a period of time subsequent to the second cycle of the cyclic activity.
- In an embodiment, the apparatus further includes a stent, and the stent is configured to be positioned against a wall of the lumen via the inflation of the balloon.
- In an embodiment, the apparatus further includes a valve disposed on the surface of the balloon, and the valve is configured to be expanded via the inflation of the balloon.
- In an embodiment, the apparatus further includes a valve configured to control flow to the balloon, and the control unit is configured to regulate movement of the surface of the balloon in the inflation-related direction by controlling the valve.
- In an embodiment, the apparatus further includes a tube configured to supply fluid to the balloon, the apparatus further includes one or more squeezing surfaces that are disposed around the tube, and the control unit is configured to inhibit movement of the surface of the balloon in the inflation-related direction by driving a current that causes the squeezing surfaces to squeeze together.
- In an embodiment, the cyclic activity includes a cardiac cycle of the subject, the portion of the subject's body includes a portion of a cardiovascular system of the subject that moves as a result of the subject's cardiac cycle, and the balloon is configured to be inflated inside the portion of the cardiovascular system.
- In an embodiment, the given phase of the cardiac cycle includes end-diastole, and the control unit is configured to move the surface of the balloon in the inflation-related direction in response to the sensor sensing end-diastole.
- In an embodiment, the apparatus further includes an instrument configured to be operated by a user, and the control unit is configured to move the portion of the tool in the given direction, (a) in response to the sensor sensing that the cyclic activity is at the given phase thereof, and (b) in response to the instrument being operated by the user.
- In an embodiment, the instrument is configured to provide force feedback to the user that is independent of the cyclic activity.
- In an embodiment, the instrument is configured to provide force feedback to the user that is smoothened with respect to the cyclic activity.
- In an embodiment, the tool includes a tubular structure configured to bypass an occlusion of a blood vessel within the portion of the subject's body.
- In an embodiment, the tubular structure includes a blood vessel graft.
- In an embodiment, the control unit is configured to move the tubular structure in the given direction by moving a distal end of the structure in a direction from (a) within the blood vessel on a proximal side of the occlusion, to (b) outside the blood vessel.
- In an embodiment, the control unit is configured to move the tubular structure in the given direction by moving a distal end of the structure in a direction from (a) outside the blood vessel, to (b) within the blood vessel on a distal side of the occlusion.
- There is further provided, in accordance with an embodiment of the invention, apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- a sensor for sensing a phase of the cyclic activity;
- a medical tool configured to mechanically perform an action during a single cycle of the cyclic activity with respect to the portion of the subject's body; and
- a control unit configured to actuate the tool to mechanically perform the action in response to the sensor sensing that the cyclic activity is at a given phase thereof.
- In an embodiment, the tool includes a balloon configured to apposition itself to a lumen of the portion of the subject's body during the single cycle by being inflated in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- In an embodiment, the balloon is configured to be inflated continuously for a period of time prior to the balloon appositioning itself to the lumen by being inflated during the single cycle.
- In an embodiment, the balloon is configured to be inflated continuously for a period of time subsequent to the balloon appositioning itself to the lumen by being inflated during the single cycle.
- In an embodiment, the tool includes a stent configured to apposition itself to a lumen of the portion of the subject's body by being expanded inside the lumen of the portion of the subject's body during a single cycle of the cyclic activity, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- In an embodiment, the stent includes a self-expansible portion configured to self-expand inside the lumen of the portion of the subject's body.
- In an embodiment, the tool includes a valve configured to be implanted within the portion of the subject's body by mechanically expanding within the portion, and the control unit is configured to actuate the valve to expand in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- In an embodiment, the cyclic activity includes a cardiac cycle of the subject, and the control unit is configured to actuate the valve to expand in response to the sensor sensing that the cardiac cycle is at the given phase thereof.
- In an embodiment, the given phase includes an end-diastolic phase of the cardiac cycle, and the control unit is configured to actuate the valve to expand in response to the sensor sensing the end-diastolic phase of the cardiac cycle.
- In an embodiment, the tool includes a septal-closure device configured to be implanted within a heart of the subject by mechanically expanding within the heart, and the control unit is configured to actuate the septal-closure device to expand in response to the sensor sensing that cardiac cyclic activity of the subject is at a given phase thereof.
- In an embodiment, the given phase includes an end-diastolic phase of the cardiac cycle, and the control unit is configured to actuate the septal-closure device to expand in response to the sensor sensing the end-diastolic phase of the cardiac cycle.
- There is further provided, in accordance with an embodiment of the invention, apparatus for use with a portion of a subject's body that undergoes neural cyclic activity, the apparatus including:
- a sensor for sensing a phase of the neural cyclic activity;
- a medical tool configured to perform a function with respect to the portion of the subject's body; and
- a control unit configured to actuate the tool to perform the function, in response to the sensor sensing that the cyclic activity is at a given phase thereof.
- There is additionally provided, in accordance with an embodiment of the present invention, apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, and for use with a sensor for sensing a phase of the cyclic activity, and for use with a medical tool configured to perform a function with respect to the portion of the subject's body, the apparatus including:
- a control unit configured:
-
- in a first cycle of the cyclic activity, to move at least a portion of the tool in a given direction, in response to the sensor sensing that the cyclic activity is at a given phase thereof,
- following the given phase in the first cycle and prior to an occurrence of the given phase in a subsequent cycle of the cyclic activity, to inhibit the movement of the at least a portion of the tool, and
- in a second cycle of the cyclic activity, subsequent to the inhibiting of the movement, to move the at least a portion of the tool in the given direction, in response to the sensor sensing that the second cycle of the cyclic activity is at the given phase thereof,
- without moving the at least a portion of the tool in a direction opposite to the given direction, between (a) moving the at least a portion of the tool in the given direction in the first cycle, and (b) moving the at least a portion of the tool in the given direction in the second cycle.
- There is further provided, in accordance with an embodiment of the invention, apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- a sensor for sensing a phase of the cyclic activity;
- a medical tool configured to perform a function with respect to the portion of the subject's body; and
- a control unit configured:
-
- in a first cycle of the cyclic activity in response to the sensor sensing that the cyclic activity is at a first given phase thereof, to move the tool,
- in a subsequent cycle of the cyclic activity in response to the sensor sensing that the cyclic activity is at the given phase thereof, to actuate the tool to execute an action selected from the group consisting of: performing the function and moving,
- following the given phase in the subsequent cycle and prior to an occurrence of the given phase in a further subsequent cycle of the cyclic activity, to inhibit the selected action of the tool, and
- in the further subsequent cycle of the cyclic activity, subsequent to the inhibiting of the action, and in response to the sensor sensing that the further subsequent cycle of the cyclic activity is at the given phase thereof, to actuate the tool to execute an action selected from the group.
- In an embodiment, the tool includes a myocardial revascularization tool configured to sequentially apply a revascularization treatment to respective treatment sites within the portion of the subject's body, and the control unit is configured to:
- actuate the tool to perform the function by actuating the tool to apply a revascularization treatment to a treatment site, and
- to move the tool by moving at least a portion of the revascularization tool toward successive treatment sites.
- In an embodiment, the control unit is configured to move the tool by moving the tool to create a defined pattern of treatment sites.
- In an embodiment, the tool includes an ablation tool configured to sequentially ablate respective ablation sites within the portion of the subject's body, and the control unit is configured to:
- actuate the tool to perform the function by actuating the tool to ablate an ablation site, and
-
- to move the tool by moving at least a portion of the ablation tool toward successive ablation sites.
- In an embodiment, the ablation tool is configured to ablate the ablation sites using an ablation technique selected from the group consisting of: laser ablation, electrocautery, RF ablation, cryogenic ablation, and ultrasound ablation.
- In an embodiment, the control unit is configured to move the at least the portion of the tool by moving the at least the portion of the tool to create a defined pattern of ablation sites.
- In an embodiment, the control unit is configured to apply a Maze procedure to the ablation sites by moving the at least the portion of the tool toward successive ablation sites.
- In an embodiment, the ablation tool is configured to apply a pulmonary vein isolation technique to a heart of the subject by moving the at least the portion of the tool toward successive isolation sites.
- In an embodiment, the tool includes an injection tool, configured to inject a substance within the portion of the subject's body, and the control unit is configured to:
-
- actuate the tool to perform the function by actuating the tool to inject the substance, and
- to move the tool by moving at least a portion of the tool toward an injection site.
- In an embodiment, the substance includes DNA molecules, and the injection tool is configured to inject the DNA molecules into heart tissue of the subject.
- In an embodiment, the substance includes stem cells, and the injection tool is configured to inject the stem cells into heart tissue of the subject.
- In an embodiment, the tool includes a needle configured to suture tissue within the portion of the subject's body, and the control unit is configured to:
-
- actuate the tool to perform the function by actuating the tool to suture the tissue, and
- to move the tool by moving the needle toward successive suturing sites.
- In an embodiment, the tissue includes tissue of the subject selected from the group consisting of cardiac tissue and coronary tissue, and the needle is configured to suture the selected tissue.
- In an embodiment, the tool includes a needle configured to aspirate tissue from an aspiration site within the portion of the subject's body, and the control unit is configured to:
- actuate the needle to perform the function by actuating the needle to aspirate the tissue, and move the needle by moving the needle toward the aspiration site.
- In an embodiment, the needle is configured to perform trans-thoracic needle aspiration.
- In an embodiment, the needle is configured to perform trans-bronchial needle aspiration.
- There is additionally provided, in accordance with an embodiment of the invention, apparatus for opening an at least partial occlusion of a lumen of a subject's body, the apparatus including:
- a sensor for sensing a phase of the cyclic activity;
- an occlusion-opening tool configured to open the occlusion; and
- a control unit configured:
-
- in a first cycle of the cyclic activity in response to the sensor sensing that the cyclic activity is at a first given phase thereof, to actuate the tool to perform an occlusion-opening action,
- following the given phase in the first cycle and prior to an occurrence of the given phase in a subsequent cycle of the cyclic activity, to inhibit the action of the tool, and
- in a second cycle of the cyclic activity, subsequent to the inhibiting of the action, and in response to the sensor sensing that the second cycle of the cyclic activity is at the given phase, to actuate the tool to perform the action.
- In an embodiment, after actuating the tool at the given phase of the first cycle and before the actuation of the tool at the given phase of the subsequent cycle, the control unit is configured to retract the tool from the occlusion.
- In an embodiment, the occlusion-opening tool includes a tool configured to open the occlusion by directing acoustic waves toward the occlusion.
- There is further provided, in accordance with an embodiment of the invention, apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- an imaging device for acquiring a plurality of image frames of the portion of the subject's body;
- a sensor for sensing a phase of the cyclic activity;
- a medical tool configured to perform a function with respect to the portion of the subject's body;
- a control unit configured to:
-
- generate a stabilized set of image frames of the medical tool disposed within the portion of the subject's body,
- actuate the tool to execute an action selected from the group consisting of performing the function and moving, in response to the sensor sensing that the cyclic activity is at a given phase thereof, and
- inhibit the tool from executing the action in response to the sensor sensing that the cyclic activity is not at the given phase; and
- a display configured to facilitate use of the tool by displaying the stabilized set of image frames of the medical tool disposed within the portion of the subject's body.
- In an embodiment, the apparatus further includes a user interface, and the control unit is configured to receive an input from a user, via the user interface, and to designate the given phase in response to the input.
- In an embodiment, the tool includes a valve configured to be implanted within the portion of the subject's body by being expanded within the portion, and the control unit is configured to actuate the valve by expanding the valve.
- In an embodiment, the tool includes a septal-closure device configured to be implanted within the portion of the subject's body by being expanded within the portion, and the control unit is configured to actuate the septal-closure device by expanding the septal closure device.
- In an embodiment, the tool includes a balloon configured to perform the function by being inflated inside a lumen of the portion of the subject's body.
- In an embodiment, the tool includes a tubular structure configured to bypass an occlusion of a blood vessel within the portion of the subject's body.
- In an embodiment, the tool includes a myocardial revascularization tool configured to sequentially apply a revascularization treatment to respective treatment sites within the portion of the subject's body, and the control unit is configured to:
- actuate the tool to perform the function by actuating the tool to apply a revascularization treatment to a treatment site, and
- move the tool by moving at least a portion of the revascularization tool toward successive treatment sites.
- In an embodiment, the tool includes an ablation tool configured to sequentially ablate respective ablation sites within the portion of the subject's body, and the control unit is configured to:
- actuate the tool to perform the function by actuating the tool to ablate an ablation site, and
- move the tool by moving at least a portion of the ablation tool toward successive ablation sites.
- In an embodiment, the tool includes an injection tool configured to inject a substance within the portion of the subject's body and the control unit is configured to:
- actuate the tool to perform the function by actuating the tool to inject the substance, and
- move the tool by moving at least a portion of the tool toward an injection site.
- In an embodiment, the tool includes a needle configured to suture tissue within the portion of the subject's body, and the control unit is configured to:
- actuate the tool to perform the function by actuating the tool to suture the tissue, and
- move the tool by moving the needle toward successive suturing sites.
- In an embodiment, the tool includes a needle configured to aspirate tissue from an aspiration site within the portion of the subject's body, and the control unit is configured to:
- actuate the needle to perform the function by actuating the needle to aspirate the tissue, and
- move the needle by moving the needle toward the aspiration site.
- In an embodiment, the tool includes an occlusion-opening tool configured to perform the function by performing an occlusion-opening action on an at least partial occlusion of a lumen of the portion of the subject's body.
- In an embodiment, the tool is configured to perform the occlusion-opening action by moving toward the occlusion, and after actuating the tool at the given phase of a first cycle and before the actuation of the tool at the given phase of a subsequent cycle, the control unit is configured to retract the tool from the occlusion.
- In an embodiment, the control unit is configured to generate the stabilized set of image frames by image tracking at least some of the plurality of image frames to reduce imaged motion of the portion of the subject's body associated with the cyclic activity.
- In an embodiment, the control unit is configured to generate the stabilized set of image frames by generating a set of tracked image frames corresponding to image frames of the portion acquired during the given phase.
- In an embodiment, the control unit is configured to generate the stabilized set of image frames by generating a set of the image frames corresponding to image frames of the portion acquired during the given phase.
- In an embodiment, the control unit is configured to reduce imaged motion of the portion of the subject's body associated with motion of the portion of the subject's body by image tracking the set of image frames.
- In an embodiment, the control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase, by actuating the imaging device to acquire the plurality of image frames only when the cyclic activity is at the given phase.
- In an embodiment, the imaging device is configured to acquire the plurality of image frames throughout the cyclic activity, and the control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase by selecting image frames corresponding to image frames of the portion acquired during the given phase from the plurality of image frames.
- In an embodiment, the control unit is configured to generate an additional stabilized set of image frames of the portion of the subject's body, by identifying a further given phase of the cyclic activity of the body system, and generating a set of the image frames corresponding to image frames of the portion acquired during the further given phase.
- In an embodiment, the cyclic activity includes a cardiac cycle of the subject, and the sensor includes a sensor for sensing a phase of the subject's cardiac cycle.
- In an embodiment, the given phase includes an end-diastolic phase of the subject's cardiac cycle, and the control unit is configured to generate a stabilized set of the image frames corresponding to image frames of the portion acquired during the end-diastolic phase of the subject's cardiac cycle.
- In an embodiment, the sensor includes an image processor configured to sense movement of the portion of the subject's body by comparing image frames of the plurality of image frames to at least one of the plurality of image frames.
- In an embodiment, the cyclic activity includes a respiratory cycle of the subject, and the sensor includes a sensor for sensing a phase of the subject's respiratory cycle.
- In an embodiment, the sensor includes an image processor configured to sense movement of the portion of the subject's body by comparing image frames of the plurality of image frames to at least one of the plurality of image frames.
- In an embodiment, the apparatus further includes an instrument configured to be operated by a user, and the control unit is configured to actuate the tool to perform the function, (a) in response to the sensor sensing that the cyclic activity is at the given phase thereof, and (b) in response to the instrument being operated by the user.
- In an embodiment, the instrument is configured to provide force feedback to the user that is independent of the cyclic activity.
- In an embodiment, the instrument is configured to provide force feedback to the user that is smoothened with respect to the cyclic activity.
- There is further provided, in accordance with an embodiment of the invention, apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, and for use with an imaging device for acquiring a plurality of image frames of the portion of the subject's body, a sensor for sensing a phase of the cyclic activity, a medical tool configured to perform a function with respect to the portion of the subject's body, and a display configured to facilitate use of the tool by displaying image frames of the portion of the subject's body, the apparatus including:
- a control unit configured to:
-
- generate a stabilized set of image frames of the portion of the subject's body,
- output the stabilized set of image frames to the display,
- actuate the tool to perform the function in response to the sensor sensing that the cyclic activity is at a given phase of the cyclic activity, and
- inhibit the tool from performing the function in response to the sensor sensing that the cyclic activity is not at the given phase.
- There is additionally provided, in accordance with an embodiment of the present invention, apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus including:
- an imaging device for acquiring a plurality of image frames of the portion of the subject's body;
- a sensor for sensing a phase of the cyclic activity;
- a medical tool configured to mechanically perform an action during a single cycle of the cyclic activity with respect to the portion of the subject's body; and
- a control unit configured to:
-
- generate a stabilized set of image frames of the portion of the subject's body, and
- actuate the tool to mechanically perform the action in response to the sensor sensing that the cyclic activity is at a given phase thereof.
- In an embodiment, the control unit is configured to generate the stabilized set of image frames by generating a set of image frames that are stabilized with respect to the given phase of the cyclic activity.
- In an embodiment, the tool includes a balloon configured to apposition itself to a lumen of the portion of the subject's body during a single cycle by being inflated, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- In an embodiment, the tool includes a stent configured to be implanted by being expanded inside a lumen of the portion of the subject's body during a single cycle of the cyclic activity, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- In an embodiment, the tool includes a valve configured to be implanted within the portion of the subject's body by mechanically expanding within the portion during a single cycle of the cyclic activity, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- In an embodiment, the tool includes a septal-closure device configured to be implanted within a heart of the subject by mechanically expanding within the heart during a single cycle of cardiac cyclic activity of the subject, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
- The present invention will be more fully understood from the following detailed description of embodiments thereof, taken together with the drawings, in which:
-
FIG. 1 is a schematic illustration of apparatus for generating a stabilized image of a portion of a subject's body, in accordance with an embodiment of the present invention; -
FIG. 2 is a schematic illustration of a heart at various phases of the cardiac cycle alongside an ECG signal associated with the cardiac cycle; -
FIG. 3 is a schematic illustration of image frames of a subject's heart being gated to a phase of a physiological cycle, in accordance with an embodiment of the present invention; -
FIG. 4 is a schematic illustration of image frames of a subject's heart being image tracked, in accordance with an embodiment of the present invention; -
FIG. 5 is a schematic illustration of image frames of a subject's heart being (a) gated to a phase of a physiological cycle, and (b) image tracked, in accordance with an embodiment of the present invention; -
FIG. 6 is a schematic illustration of apparatus for synchronizing actuation of a medical device with a physiological cycle, in accordance with an embodiment of the present invention; -
FIGS. 7A-B are schematic illustrations of the actuation of inflation of a balloon in synchronization with a physiological cycle, in accordance with an embodiment of the present invention; -
FIG. 7C is a graph schematically showing the pressure of the balloon as a function of time, in accordance with an embodiment of the present invention; -
FIG. 8 is a schematic illustration of apparatus for facilitating the synchronized inflation of a balloon, in accordance with an embodiment of the present invention; -
FIGS. 9-11 are schematic illustrations of apparatus for facilitating the synchronized inflation of a balloon, in accordance with another embodiment of the present invention; -
FIG. 12 is a schematic illustration of apparatus for facilitating the synchronized inflation of a balloon, the apparatus being built into an inflation device, in accordance with a further embodiment of the present invention; -
FIG. 13 is a schematic illustration of synchronization of the penetration of an occlusion of a blood vessel with cyclic movement of the blood vessel, in accordance with an embodiment of the present invention; -
FIG. 14 is a schematic illustration of a modulator for synchronizing the penetration of an occlusion of a blood vessel with the cyclic movement of the blood vessel, in accordance with an embodiment of the present invention; -
FIG. 15 is a schematic illustration of a handheld actuator that comprises the modulator shown inFIG. 14 , in accordance with an embodiment of the present invention; and -
FIG. 16 is a schematic illustration of the synchronization of a transluminal placement of a coronary bypass graft with the cyclic motion of a portion of the subject's body, in accordance with an embodiment of the present invention. - As used herein:
-
- The term “physiological signal or process” refers to any cyclical physiological signal or process in the patient's body including, but not limited to, ECG, blood pressure (e.g., systolic and diastolic), Peripheral Arterial Tone, EEG, respiration, the shifting/expansion/contraction of an organ, acquired images in which any of the above signals or processes may be observed, or any combination, derivation, extrapolation or manipulation thereof.
- The terms “medical tool,” “tool” and “probe” mean any type of a diagnostic or therapeutic or other functional tool including, but not limited to, a cardiovascular catheter, a stent delivery and/or placement and/or retrieval tool, a balloon delivery and/or placement and/or retrieval tool, a valve delivery and/or placement and/or retrieval tool, a graft delivery and/or placement and/or retrieval tool, a tool for the delivery and/or placement and/or retrieval of an implantable device or of parts of such device, an implantable device or parts thereof, a guide wire, a suturing tool, a biopsy tool, an aspiration tool, a navigational tool, a localization tool, a probe comprising one or more location sensors, a tissue characterization probe, a probe for the analysis of fluid, a measurement probe, an electrophysiological probe, a stimulation probe, an ablation tool, a tool for penetrating or opening partial or total occlusions in blood vessels, a drug or substance delivery tool, a chemotherapy tool, a photodynamic therapy tool, a brachytherapy tool, a local irradiation tool, a laser device, a tool for delivering energy, a tool for delivering markers or biomarkers, a tool for delivering biological glue, an irrigation device, a suction device, a ventilation device, a device for delivering and/or placing and/or retrieving a lead of an electrophysiological device, a lead of an electrophysiological device, a pacing device, an imaging device, a sensing probe, a probe comprising an optical fiber, a robotic tool, a tool that is controlled remotely, or any combination thereof.
- The terms “image” and “imaging” refer to any type of medical imaging, typically presented as a sequence of images and including ionizing radiation, non-ionizing radiation, video, fluoroscopy, angiography, ultrasound, CT, MRI, PET, PET-CT, CT angiography, SPECT, Gamma camera imaging, Optical Coherence Tomography (OCT), Vibration Response Imaging (VRI), Optical Imaging, infrared imaging, electrical mapping imaging, other forms of Functional Imaging, or any combination or fusion thereof. Examples of ultrasound imaging include Endo-Bronchial Ultrasound (EBUS), Trans-Thoracic Echo (TTE), Trans-Esophageal Echo (TEE), Intra-Vascular Ultrasound (IVUS), Intra-Cardiac Ultrasound (ICE), etc.
- The terms “periodic” and “cyclical,” when used in the context of the motion of a body organ, are interchangeable.
- The terms “gating” and “synchronization,” and their various derivations, when used in the context of synchronizing between an image display and one or more physiological signals or processes or between the activation of a medical tool and one or more physiological signals or processes, are interchangeable. (The term “coherence” has also been known to describe the same.)
- The terms “stationary” and “stabilized,” when used in the context of displayed images, mean a display of a series of images in a manner such that the periodic or cyclical motion of the body organ(s) being imaged is typically, partially or fully, reduced or not noticeable to the viewer. Typically, such images are gated to one or more physiological signals or processes whose cycle(s) correspond to a motion cycle of the organ being imaged.
- The term “virtual stabilization,” when used in reference to a moving organ, refers to a situation where the displayed images of said organ are stabilized, partially or fully, with respect to the motion of the organ, and/or tool(s) applied to the organ are actuated in synchronization with a selected phase in the motion of the organ. (Motion of the organ may comprise cyclical and non-cyclical motion.) Consequently, the moving organ is typically viewed and/or acted upon as if it is in a situation of (partial or full) virtual stabilization.
- The terms “synchronizing” and “gating,” and derivations thereof, when used in reference to an image stream, describes the identification and selection of individual image frames from such image stream, wherein such frames are acquired at a same selected phase in a plurality of occurrences of a cyclical physiological signal or process.
- The term “gating,” and derivations thereof, when used in reference to a medical tool, describes the movement and/or application of the tool at a same selected phase in a plurality of occurrences of a cyclical physiological signal or process.
- The term “image tracking” is used to describe a process by which images (including images acquired at different phases in the motion of an organ) are aligned to one another by means of aligning among such images one or more features, or regions of interest, that are observable in most or all images. The term should be construed to be synonymous with the terms “video tracking,” “frame tracking,” and “object tracking.”
- The term “real time,” when used in reference to the application of virtual stabilization or of an element thereof, means without a noticeable delay.
- The term “near real time,” when used in reference to the application of virtual stabilization or of an element thereof, means with a short noticeable delay (such as approximately one or two motion cycles of the applicable organ, and, in the case of procedures relating to organs or vessels the motion of which are primarily as a result of the cardiac cycle, less than 4 seconds).
- In some embodiments, apparatus and methods are provided for facilitating medical procedures performed on cyclically-moving organs, so that such procedures are performed under a partial or full virtual stabilization of such organs. The virtual stabilization typically comprises two elements, namely (a) the stabilization of the image(s) of the organ and (b) the synchronization of tool(s) being actuated and/or moved, with the movement of the organ. At least one of these two major elements is applied.
- Examples of organs which move cyclically include, but are not limited to, the heart, the coronary blood vessels, the aorta, certain other blood vessels (e.g., renal, carotid), the majority of the respiratory tract, certain parts of the digestive tract (e.g., the stomach, the small intestine), certain parts of the thorax (e.g., the diaphragm), the eyes, etc. The description hereinbelow relates mainly to the example of the body organ being the heart and/or the coronary blood vessels, and the physiological signal used for synchronization or gating in such examples is typically the ECG. However, the scope of the invention includes applying the apparatus and methods described hereinbelow to any portion of a subject's body that moves as a result of the cyclic activity of a body-system of the subject.
- Reference is now made to
FIG. 1 , which is a schematic illustration of apparatus for acquiring image frames of a portion of a subject's heart, in accordance with an embodiment of the present invention. An angiographic/fluoroscopic camera 11 acquires a plurality of image frames, throughout the cyclic activity of the heart. When the image frames are not stabilized, an image orvideo stream 14 is generated, which is blurred due to the cyclical motion of the imaged heart. - In some embodiments, the apparatus generates a stabilized
video stream 15 by a gating procedure performed byprocessor 13 in response to anECG signal 12, a blood pressure sensor, a displacement sensor, a vibration sensor and/or any combinations or derivations thereof, thus yielding said stabilized image orvideo stream 15. Alternatively or additionally, the image frames are gated with respect to the subject's respiratory cycle. In some embodiments, the subject's respiratory cycle is detected by means of a respiration sensor, such as a stretch belt, a displacement sensor, a vibration sensor, and/or any combinations or derivations thereof. - In some embodiments, the aforementioned gating is performed directly in conjunction with the actual expansion and contraction of the heart muscle in the course of the cardiac cycle, as such expansion process is observed by the fluoroscopic/angiographic camera, discerning by means of image processing the relative distances among identifiable features such as the coronary blood vessels.
- In some embodiments, gating is performed initially with respect to the ECG signal, or to another signal corresponding to cardiac motion, and/or to any combination or derivation of signals thereof, but afterwards gating is performed by means of image processing. For example, an image frame corresponding to a selected phase in the ECG signal is identified and determined to be a “baseline image frame.” After such identification of a “baseline image frame” has been achieved, gating of the subsequent image stream is done by means of selecting those image frames where the shape of the observed anatomy is identical, or most similar, to the shape observed in the baseline image frame.
- For some applications, the aforementioned gating is applied directly to the radiation source of the fluoroscopic/angiographic camera, so that imaging is performed intermittently, e.g., only during or leading up to one or more specific phases in the cardiac cycle at which the acquisition of a (gated) image frame is desired.
- Techniques described herein, above or below, may be practiced in combination with techniques described in one or more of the references cited in the Background section of this application.
- The stabilized image frames are typically produced at the rate of the patient's heart rate. The resulting frame rate is typically one or two frames per second, which is considered a low-frame rate compared to what the human eye interprets as continuous. In some embodiments, a gap filling technique is applied among the image frames that were selected for display by the gating. Additional intermediate image frames are generated, thus increasing the visible frame rate, typically smoothening the transitions among the gated and displayed images and making the image stream easier to observe. In some embodiments, such gap filling utilizes image processing methods such as blending, morphing or a combination thereof.
- In some embodiments, the gap-filling techniques include a predictive algorithm that is applied to generate image frames after the most recent gated and displayed image frame, but prior to the next gated and displayed image frame. For example, an image processor determines a characteristic of motion of the tool, based upon previously-acquired image frames. The motion profile is extrapolated to generate a simulated image frame of the tool by assuming that the tool continues to move according to the determined profile. The simulated image frame is then used as an intermediate image between successive image frames.
- In some embodiments of the gap-filling, visual information from images that were acquired in the original image stream, but are not displayed in the gated image stream, may be used to discern some of the changes that have occurred since the most recent gated and displayed image. Those changes are then applied to the most recent gated and displayed image, to generate new image frames ahead of the next gated and displayed image. For example, in a beating heart wherein medical tools are manipulated, such visual information may comprise changes in tool positions relative to visible anatomical landmarks that move together with the heart. Such changes are then applied to the most recent gated and displayed image, leading to a representation of the tool being generated and displayed within the stabilized video stream ahead of the next gated and displayed image frame.
- The gap filling described hereinabove is applied by
processor 13. Typically, it is applied in the transition between every two consecutive gated image frames. The resulting, stabilized video stream is typically displayed in the course of the procedure, and typically in real time or in near real time. - In some embodiments, the stabilized video stream is stored and is displayed subsequent to the procedure in which the image frames are acquired.
- In some embodiments, two or more of the streams of images, including the original “jumpy” images and the “smoothened” gated images, are displayed side by side (which may be achieved using two or more separate physical displays, or using two or more software windows within the same physical display).
- In some embodiments, the “smoothened,” gated image stream is displayed in a shared manner on the same display that is used for other purposes in the procedure room, such as on an existing “main” or “reference” or “re-loop” display in a coronary catheterization lab.
- Reference is now made to
FIG. 2 , which is a schematic illustration of a heart at various phases of the cardiac cycle alongside an ECG signal associated with the cardiac cycle.FIG. 2 illustrates the correspondence between triggeringpoints - In some embodiments, an operator (e.g., an interventional cardiologist) shifts the phase point to view the cardiac image at any desired phase in the cycle of the ECG signal, via an input to processor 13 (shown in
FIG. 1 ). In some embodiments, the specific phase of the cardiac cycle to which the displayed images are gated may be changed by the operator in the course of viewing the images. - In some embodiments, the stabilized video stream is gated specifically to the end of the diastolic phase of the cardiac cycle. (At the end-diastolic phase the ventricles are typically at their peak volume.) In addition, the inventors hypothesize that the coronary blood vessels may be spread apart at the end-diastolic phase of the cardiac cycle, and, for example, in the case of an angioplasty procedure, that may be the view most desired by a physician. Alternatively the stabilized video stream is gated to a different phase of the subject's cardiac cycle, for example, systole, or mid-diastole.
- In some embodiments, more than one stabilized video stream is displayed concurrently. For example, a stabilized video stream at a diastolic phase of the cardiac cycle is displayed concurrently with another stabilized video stream at a systolic phase of the cardiac cycle.
- In some embodiments, the gated images at different phases of the cardiac cycle form a basis for determining a parameter of the subject's cardiovascular system, for example, the ejection fraction of the heart (using image processing techniques known in the art, mutatis mutandis). In some embodiments, image streams are stabilized with respect to two or more phases of the subject's respiratory cycle, and a parameter of the subject's respiratory cycle is determined using one, or both of the image streams, for example, by comparing the image streams to each other. For example, the subject's tidal volume may be determined by determining from the image streams the size of the subject's lungs at the end of the exhalation phase of the subject's respiratory cycle and the size of the subject's lungs at the end of the inhalation phase of the cycle.
- In some embodiments, processor 13 (
FIG. 1 ) stabilizes the image of the portion of the subject's body with respect to additional motion of the portion. Some physiological signals or processes correspond to a change in the shape of the organs being imaged. Other signals or processes mainly correspond to a change in the location of such organs but have less of a correspondence to their shape. In some cases, signals or processes of those two categories apply to a certain organ or organs concurrently. For example, in the case of the heart and the coronary blood vessels, those organs typically twist, contract and expand in the course of the cardiac cycle (also corresponding to the ECG signal), while at the same time they also typically shift up and down in the course of the respiratory cycle. In addition, such organs may shift in a non-cyclical manner due to “whole-body motion” of the subject, for example, due to the subject coughing or moving on his/her bed. (“Whole-body motion” is to be understood as referring to non-cyclical, noticeable motion of an external portion of the subject's body, even in the absence of the subject's entire body moving.) - In some embodiments, for the creation of a stabilized video stream of the organ(s) being imaged, a cyclical signal or process typically corresponding to a change in the shape(s) of such organ(s) is accounted for by means of gating. Subsequently, another signal or process, typically corresponding mainly to a change in the location of such organs, is accounted for by means of an image tracker. For example, in the case of the heart and/or associated blood vessels, gating to the ECG signal is applied to create one or more video streams, each of which is stabilized with respect to a specific phase in the cardiac cycle. Image tracking is then applied to the aforementioned gated video stream(s) in order to further stabilize the stream(s) with respect to the respiratory cycle.
- In some embodiments, gating followed by image tracking is applied to respective image frames, in a frame-by-frame manner, such that an individual gated frame is image tracked prior to the next gated frame being acquired. Alternatively, gating is applied to a batch of image frames to generate a set of gated image frames. Image tracking is then applied to the set of gated image frames.
- In some embodiments, the image tracker is applied to motion that is typically not of a cyclical nature, such as whole-body motion of the patient in the course of the procedure. As a result, such motion of the patient is absent from, or substantially reduced in, the stabilized image stream being viewed by the physician.
- The sequence in which the aforementioned gating, image tracking and gap filling are applied to images in the originally-acquired image stream may vary.
- In some embodiments, and for the purpose of creating a stabilized video stream of a cyclically-moving organ, the typically higher frequency of two physiological signals or processes corresponding to a motion of said organ is gated, and subsequently the signal or process which is typically of a lower frequency, and/or any additional motion of the organ, is accounted for by means of image tracking. For example, such sequence may reduce the computational resources required for image stabilization. Alternatively, the typically lower frequency of the two physiological signals or processes is gated, and the signal or process which is typically of a higher frequency, and/or any additional motion of the organ, is accounted for by means of image tracking.
- In some embodiments, the stabilization of the video stream of the cyclically-moving organ is achieved by accounting for the second aforementioned signal or process by means of image tracking prior to (and not following) accounting for the first aforementioned signal or process by means of gating. For example, such a sequence may be useful in some of the aforementioned gap-filling algorithms. Specifically, for some applications, visual information of changes in tool positions relative to anatomical landmarks is easier to identify in image tracked images before the images are gated.
- In some embodiments, image tracking followed by gating is applied to respective image frames (typically, in real time or near real time). Alternatively, a batch of image frames are image tracked and subsequently the tracked image frames are gated.
- In some embodiments, image frames are gated with respect to the respiratory cycle, and are image-tracked with respect to movement related to the subject's cardiac cycle.
- The image tracker applied in the aforementioned embodiments may be an edge tracker, a centroid tracker, a correlation tracker, an object tracker, or any combination thereof. Such image tracker typically neutralizes, in the eyes of the viewer of a stabilized video stream, the change in location of the organs being imaged, thus maintaining the organ at a desired location on the display (such as its center), even though the organ being imaged is in constant motion.
- Reference is now made to
FIG. 3 which is a schematic illustration of avideo stream 33 of a subject's heart being gated to a phase of the subject's cardiac cycle, in accordance with an embodiment of the present invention. Avideo camera 31, acquires avideo stream 33 of the subject's heart. AnECG 32 detects the subject's cardiac cycle. Agating processor 34 of control unit 13 (FIG. 1 ) selects image frames 35 corresponding to a given phase of the cardiac cycle as reflected by a given point inECG 32. In some embodiments, abuffer 36 is used for gap filling the transitions amongimages 35. The resulting stabilized video stream is presented ondisplay 37. Reference is now made toFIG. 4 , which is a schematic illustration of avideo stream 41 of a subject's heart being image tracked, in accordance with an embodiment of the present invention. Typically,video stream 41 is the output of gating processor 34 (FIG. 3 ). Amask 45 is generated from image frames ofvideo stream 41 of the subject's heart. Bothmask 45 and the image frames are fed into acorrelator 42.Correlator 42 identifiesmask 45 in each new image frame, and by doing so identifies the deviation in the location of the mask within the current image frame relative to its location in the prior image frame.Image corrector 43 utilizes the output ofcorrelator 42 for realigning each new image frame such that the relative location ofmask 45 within each such new image frame remains constant. Consequently, trackedvideo stream 44 is produced. In embodiments in which the input tocorrelator 42 andimage corrector 43 is the output of gating processor 34 (FIG. 3 ),video stream 44 is both image tracked and gated to a given point in the ECG. - Reference is now made to
FIG. 5 , which is a schematic illustration of a video stream of a subject's heart being (a) gated 51 to a phase of a physiological cycle (as described with reference toFIG. 3 ), and (b) image tracked 52 (as described with reference toFIG. 4 ), in accordance with an embodiment of the present invention. The combined application ofprocesses - Typically, when using the combined application of gating and image tracking as in the sequence shown in
FIG. 5 , the aforementioned smoothening or gap filling in the transformations among selected image frames is performed on the output of the gating and the image tracking (i.e., on the output ofFIG. 5 ). In such a case, each individual image frame which is an output of the gating serves as an input for image tracking. After going through both gating and image tracking, each individual frame becomes both gated and image tracked, and the gap filling is performed on the transformations between successive gated-and-image-tracked frames. - It is noted that, as described, the scope of the present invention also includes performing image tracking prior to performing gating (configuration not shown in the figures). In this case, the smoothening algorithms described herein are generally applied to the output of the gating.
- In some embodiments, a path for passing tools into desired locations in the heart and/or coronary blood vessels is generated. In some embodiments, such a path is also displayed.
- In some embodiments, stabilized road mapping is applied to cyclically-moving organs such as the coronary blood vessels, the pulmonary vessels, the aorta, and/or to the heart itself. Road mapping is typically helpful in reducing radiation time and/or the amount of contrast agent being used to facilitate medical procedures. Road mapping is commonly used in catheterization procedures in organs that can typically remain motionless throughout the procedure, such as blood vessels in the limbs. One embodiment of road mapping is named Digital Subtraction Angiography (DSA).
- The use of road mapping is typically difficult with conventional, constantly moving cardiac images, because the historical roadmap and the displayed images are typically not aligned with one another most of the time. Thus, road mapping is typically not used in procedures performed on moving organs, such as coronary interventions.
- In some embodiments of the current invention, a historical roadmap which was generated in the same phase of the cardiac cycle to which the displayed, stabilized video stream is gated and from the same viewing angle, is displayed as a background to the real-time, stabilized video stream. (In some embodiments, the aforementioned use of image tracking is also applied, for example, in order to compensate for the effect of the respiratory cycle.) The roadmapping typically generates an image of the coronary vessels highlighted with a contrast agent. Consequently, the real-time image of tools inserted through such vessels is typically viewed as superimposed on the roadmap of those same vessels at the same gated phase in the cardiac cycle. In some embodiments, by generating a stabilized roadmap, manipulation of tools is facilitated, and/or cumulative radiation throughout the procedure is reduced, and/or the cumulative amount of contrast agent injected throughout the procedure is smaller.
- Typically the contrast agent is injected into a space within the subject's cardiovascular system, for example, a chamber of the subject's heart, a coronary blood vessel, and/or the subject's aorta.
- In some embodiments, using roadmapping facilitates the direct stenting of the subject's coronary arteries, without requiring a prior step of pre-dilatation. In such embodiments, the roadmap typically improves the ability to place the stent accurately and thus reduces the need to inflate a balloon which does not carry a stent prior to the deployment of the stent itself. That, in turn, typically reduces procedure time and/or cost.
- In some embodiments, direct stenting as described herein is capable of reducing the risk of embolization which may otherwise be created if pre-dilatation is performed at a slightly different location from that of the subsequent deployment of the stent. If such a difference in location exists, then the occluding substance or tissue that is being inflated and fragmented by a pre-dilatation balloon may not be subsequently kept in place by the stent, and thus embolization might occur.
- Generation of the aforementioned roadmap is typically benefited by knowledge by the system of when contrast agent is being injected. In some embodiments, the injection of contrast agent for highlighting the vessels is sensed, for the purpose of generating the aforementioned roadmap, via an electrical signal indicating the activation of the injection sub-system. Alternatively or additionally, the injection of contrast agent for highlighting the vessels is identified by means of image processing. Further alternatively or additionally, the injection of contrast agent for highlighting the vessels is identified by means of analyzing changes in the image (such as via a histogram) of the region at the distal end of the catheter from which the contrast agent typically comes out (such as a guiding catheter in the case of coronary road mapping). Changes in the image include a relatively abrupt change in the color and/or grayscale level (darkness) of a relatively large number and/or portion of image pixels, or the appearance of vessel-like features in the image, etc., or any combination thereof. It is noted that by assessing a change in the darkness level to identify the time of injection of the contrast agent, the control unit may identify a darker area of the image or a lighter area of the image, depending on whether the contrast agent is represented as dark or light. It is additionally noted that whereas specifically assessing the region at the distal end of the catheter typically enhances signal to noise (because this region is most likely to show an abrupt change), the scope of the present invention includes assessing all of the acquired image data to identify the injection of the contrast agent.
- In some embodiments, the road map being displayed in conjunction with the stabilized video stream loops among multiple images of different moments in the injection and dissipation process of the contrast agent, wherein all of those images were originally gated to a same phase in the cardiac cycle to which the currently-displayed, stabilized video stream is gated.
- In some embodiments, the road map being displayed in conjunction with the stabilized video stream comprises an image of the contrast agent itself. In some embodiments, the road map comprises a synthesized background(s), enhancement(s), contour(s), pattern(s), texture(s), shade(s) and/or color(s) that was created based upon the visual information acquired from the injection and/or dissipation of contrast agent, using computer graphics and/or image processing techniques. In some embodiments, the gray level of the road map is inversed, such that the road map appears light against a darkened background.
- In some embodiments, the summation or combination of two road maps generated at different times in the procedure is displayed. In some embodiments, a road map generated during a given phase of a first cardiac cycle is summed with a road map generated during a same phase of a second (typically immediately subsequent) cardiac cycle, to create a combined road map that displays more coronary vessels and/or displays coronary vessels with greater clarity. In some embodiments, in the case of a total or partial occlusion in a coronary vessel, the combined road map may comprise the summation or combination of a roadmap created from an injection of a contrast agent proximally to the occlusion, and a second road map created from an injection of a contrast agent distally to the occlusion, such as via a collateral vessel and/or in a retrograde direction. In these embodiments, the roadmaps based on the proximally- and distally-injected contrast agent are created in the same phase of one or more cardiac cycles that are not necessarily adjacent cardiac cycles.
- In some embodiments, a three-dimensional road map is constructed by combining two or more two-dimensional road maps recorded from viewing angles that are typically different by 30 degrees or more. In some embodiments, the two two-dimensional road maps (from which a three-dimensional road map is constructed) are recorded concurrently from two different viewing angles by means of a bi-plane fluoroscopy system. In some embodiments, a three-dimensional road map is created from CT angiography images, typically pre-procedural ones, and then correlated with the real-time two-dimensional road map created from intra-procedural angiography. In some embodiments, a three-dimensional road map is constructed from two or more different images taken from the same viewing angle but during different phases in the cardiac cycle.
- In some embodiments, markings are applied upon the stabilized images. For example, in the case of coronary angioplasty, such markings may be applied to the longitudinal edges of an occlusion, or to the region in which pre-dilatation was performed, etc. In some embodiments, such markings are applied manually with an input device such as a computer mouse, or by a stylet in the case of a tablet computer. In some embodiments, such markings are applied by hand on a touch screen. In some embodiments, such markings appear to the viewer, throughout subsequent changes in the viewing angle and/or zoom level or the fluoroscopy/angiography system, as if they remain attached to the blood vessels to which they refer. Such virtual attachment is typically performed by means of image processing. In some embodiments, the markings comprise a scale or a grid that is generated on the stabilized image, to indicate to the physician the dimensions of the image.
- In some embodiments, on-line geometric and/or hemodynamic measurements (e.g., size, flow, ejection fraction) are made and/or displayed upon the stabilized images. “On-line” in this context means that the measurements are made on the stabilized image stream, as opposed to being made on frozen images extracted from an image stream. For example, in the case of angioplasty, such measurements, also known as Quantitative Coronary Analysis (QCA), may include the length and inner diameter(s) of the occlusion and be used as inputs for the selection of a balloon and/or a stent. In some embodiments, the known size of an object seen in the stabilized images, such as the outer diameter of an introducing catheter or the size of a patch adhered to the patient's chest or the distance between radiopaque markers on a tool, is used as a reference in making such measurements. In some embodiments, the orientation at which the medical tool is disposed within the subject's body is determined, by determining an apparent distance between radiopaque markers on a tool within the stabilized set of image frames, with respect to the known distance of the markers from each other. In some embodiments, the physical size corresponding to an image pixel, as known from the imaging system, is used as a reference (in which case no physical reference object is required).
- In some embodiments, the deployment of an endovascular device, for example a balloon or a stent, is visually simulated prior to actually being performed. For example, a virtual stent of selected length and diameter may be visually placed and displayed, within the stabilized image stream, as if it were situated at the site of the occlusion. The suitability of the intended dimensions as observed with the virtual stent can then be visually validated by the physician prior to selecting and deploying the physical stent. For some applications, multiple virtual stents, such as in preparation for the stenting of a vascular bifurcation where a physical stent will be required in each branch, are virtually placed and matched with one another prior to their actual deployment. In some embodiments, a virtual stent is placed in proximity to a physical, already-deployed stent to verify that the two match one another prior to deploying the second, physical stent.
- In some embodiments, the proper deployment of a virtual tool is estimated by viewing it upon two stabilized images streams, each corresponding to a different phase of the cardiac cycle. In some embodiments, one such phase is diastolic while the second phase is systolic. In some embodiments, in response to determining an orientation at which a real medical tool (e.g., a catheter) is disposed within the subject's body, the virtual tool is deployed at a corresponding (e.g., identical) orientation.
- In some embodiments, an operator manipulates an image of a virtual tool deployed within the stabilized image stream, until the virtual tool is of appropriate dimensions. A reference number of a real tool that best corresponds to the dimensions of the virtual stent is generated. (The reference number may be, for example, a catalog number of a real tool.) Alternatively or additionally, the dimensions of a real tool that corresponds to the dimensions of the virtual tool are generated. In some embodiments, image processing is applied to the simulated image of the virtual stent to determine the curvature of a region in which the virtual stent is deployed and dimensions of a real tool are generated that incorporate the curvature of the region. In some embodiments, the orientation of the region in which the virtual tool is deployed is determined in order to generate the dimensions of a corresponding real tool.
- In some embodiments, the proper deployment of an actual stent is assessed by viewing the stent within two stabilized images streams, each corresponding to a different phase of the cardiac cycle. In some embodiments, one such phase is diastolic, while the second phase is systolic.
- In some embodiments, image processing techniques are applied to enhance the image of (a) an endovascular device, and/or (b) radiopaque markers which a device comprises, and/or (c) the walls of the vessel in which the device is situated, within the stabilized image stream. For example, the device may be a balloon and/or a stent that is implanted in the subject's body or that is transiently placed within the subject's body. Typically, such enhancement is more easily generated in a stabilized video stream in which the enhanced object is relatively stable, compared with in a non-stabilized stream of images wherein the object being enhanced is constantly shifting. In accordance with embodiments of the invention, such enhancement may be performed on-line, within the stabilized image stream. Consequently, in such embodiments, proper deployment of the endovascular device being deployed may be verified by the physician during a procedure.
- In some embodiments, the stabilized image stream is used for on-line measurement of the flow within a vessel, by measuring the time it takes contrast agent to travel a known distance. In some embodiments, the stabilized image stream is used for on-line measurement of the saturation of contrast agent within targeted tissue, such as heart muscle.
- In some embodiments, additional images, such as images produced by other modalities in a same or similar phase of the cardiac cycle to which the stabilized video stream is gated, are co-displayed. For some applications, such images are pre-operative, intra-operative, or a combination of the two. Alternatively or additionally, such images are two-dimensional or three-dimensional. The modalities from which such images originate are used before or during coronary procedures and include, without limitation, fluoroscopy, CT, MRI, CT angiography, Trans Esophageal Echo (also known as TEE), Trans Thoracic Echo (also known as TTE), Intra Vascular Ultrasound (also known as IVUS), Intra Cardiac Ultrasound (also known as Intra Cardiac Echo, or ICE), Optical Coherence Tomography, Intra Vascular MRI, or any combination thereof. In some embodiments, the co-display of such images together with the aforementioned gated video stream is performed via fusion (e.g., image overlay), using image-to-image registration techniques. Such a co-display typically provides the operator with enhanced clinical information.
- (Throughout the specification and the claims, the term “overlay” and derivations thereof, should not be understood to denote a particular order in which two or more images are combined. Rather, it refers generally to the combination of two or more images that are overlaid in space.)
- In some embodiments, a first set of images are acquired by a first imaging device from outside a portion of the subject's body, for example by CT or using a fluoroscope. A second set of images are acquired by a second imaging device from within the portion of the subject's body, for example, using an intra-vascular ultrasound probe, or an intra-vascular MRI probe. In some embodiments, the first set of images are acquired before the second set of images are acquired, and the two sets of images are registered to each other. Alternatively, the first imaging device and the second imaging device acquire the respective sets of image frames simultaneously.
- In some embodiments, images generated by an ultrasound probe (such as IVUS) within a coronary vessel are used in conjunction with the stabilized image stream (such as a stabilized fluoroscopic image stream) in the following manner:
- i. The fluoroscopic image stream is stabilized.
- ii. An IVUS catheter is inserted to the site of an occlusion under fluoroscopic imaging, to inspect endoluminal anatomy.
- iii. The image slices generated by the IVUS are recorded and stored in tandem with the visual location (such as display coordinates) of the distal tip of the IVUS catheter as seen by the fluoroscopy.
- iv. The IVUS catheter is retrieved to make room for balloon/stent deployment.
- v. A catheter with a balloon and/or stent is inserted to the site of the occlusion, under fluoroscopic imaging.
- vi. The location of the distal tip of the catheter carrying the balloon and/or stent is visually recognized (such as via display coordinates).
- vii. The IVUS images previously recorded at the same location are displayed, together with the fluoroscopic images. In some embodiments, the IVUS images are displayed in a separate window (but on the same screen as the fluoroscopic images). In some embodiments, the IVUS images are displayed on a separate screen. In some embodiments, the IVUS images being displayed are two-dimensional (also known as “slices”). In some embodiments, a three-dimensional “tunnel-like” reconstruction of the IVUS images of the vessel (or a section thereof) is displayed. In some embodiments, the IVUS images are overlaid on the fluoroscopic images. In some embodiments, the IVUS images are fused with the fluoroscopic images.
- viii. As a result, the balloon and/or stent may be deployed based upon an on-line combination of real-time fluoroscopic images and of IVUS images recorded earlier (for example, several minutes earlier).
- Although embodiments of the invention are, described primarily with reference to the heart, connecting vessels (e.g., aortic, pulmonary) and coronary blood vessels, embodiments of the current invention are similarly applicable to any other organ affected by periodic motion and/or periodic activity. An example for the latter would be the brain.
- Reference is now made to
FIG. 6 , which is a schematic illustration of apparatus for synchronizing actuation of a medical device with a physiological cycle, in accordance with an embodiment of the present invention. Cyclically-movingorgan 61 is imaged by imagingdevice 62. Non-gated image frames are displayed ondisplay 64. A cyclical physiological signal used for synchronization is transmitted vialine 68 toprocessor 63. Gated image frames are displayed ondisplay 66, which is connected toprocessor 63. In some embodiments, gap filling is applied to the gated image frames. In some embodiments, such images are also image tracked.Actuator 65 is actuated in a synchronized manner, with respect to the synchronization signal transferred fromprocessor 63 via aline 69.Actuator 65, in turn, controlstool 67, which is applied toorgan 61. - The scope of the present invention includes synchronizing, with respect to a physiological cycle, the actuation and/or movement of a medical device that performs a function on a portion of a subject's body, without stabilizing images of the portion,
- The scope of the present invention includes synchronizing, with respect to a physiological cycle, the actuation and/or movement of a medical device that performs a function on a portion of a subject's body, in combination with stabilizing images of the portion.
- The scope of the present invention includes synchronizing, with respect to a given phase of a physiological cycle, the actuation and/or movement of a medical device that performs a function on a portion of a subject's body, and stabilizing images of the portion with respect to the same given phase of the cycle.
-
FIGS. 7A-C and 8 through 12 are schematic illustrations of apparatus for inflation of a balloon, such as for widening an occlusion within a coronary blood vessel, in synchronization with the patient's cardiac cycle, in accordance with respective embodiments of the invention. In some embodiments, a stent, which is positioned around the balloon, is expanded by inflating the balloon. In some embodiments, the embodiments shown inFIGS. 7-12 are practiced in combination with stabilized imaging techniques described hereinabove. - Typically, the placement and inflation of the balloon is performed in a same selected specific phase of the cardiac cycle. That typically leads to accuracy in the placement of the balloon at a given location.
- In cases where a single cardiac cycle is shorter than the time it takes to easily or safely inflate a coronary balloon, inflation in some embodiments is performed in an intermittent (i.e., a stepwise) manner, in the course of a same selected phase in multiple cardiac cycles (
FIG. 7C ). - In other embodiments, one or more segments of the inflation of the balloon is performed continuously (i.e., not in synchronization to the cardiac cycle) and one or more segments of the inflation of the balloon is performed in the aforementioned synchronized, stepwise manner. In one embodiment, synchronized inflation until the balloon becomes fixed to the inner wall of the lumen is followed by continuous inflation until the balloon is inflated to a target diameter or volume. In another embodiment, the balloon is inflated continuously till it reaches a given volume but is not yet fixed to the inner walls of the lumen, followed by synchronized inflation until it becomes fixed to the inner walls of the lumen. In a third embodiment, the balloon is first inflated continuously until it reaches a given volume, then inflated in a synchronized manner until it becomes attached to the inner wall of the lumen, and then inflated continuously again until it reaches a desired diameter or volume.
- In some embodiments, the aforementioned synchronized placement and inflation are performed while viewing the aforementioned stabilized image as described with reference to
FIG. 1 . - In some embodiments, the specific phase to which the inflation of the balloon is synchronized is the end of the diastole phase of the cardiac cycle. At the end-diastolic phase of the cardiac cycle, the ventricles are typically at their fullest volume. Furthermore, the inventors hypothesize that during the end-diastolic phase of the cardiac cycle, the coronary arteries are typically the most spread apart, and typically remain in that situation for a fraction of a second. Such timing may further assist in the correct apposition of a stent positioned upon the balloon. Alternatively or additionally, the inflation of the balloon is gated to a different phase of the subject's cardiac cycle, for example, a mid-diastolic phase or a systolic phase.
- Reference is now made to
FIGS. 7A-B , which are schematic illustrations of the actuation of inflation of aballoon 73 in synchronization with a physiological cycle, in accordance with an embodiment of the present invention. As shown inFIG. 7A ,blood vessel 71 is clogged by occluding substance ortissue 72.Balloon 73 is positioned at the occlusion and inflated byactuator 75 via a tube. According to some embodiments of the current invention, a synchronization signal derived from the patient's ECG is provided vialine 74. The ECG signal is used to trigger the increased inflation pressure ofballoon 73 in a stepwise manner, wherein each step occurs in the same selected phase of the ECG cycle. The result is sequence 76 (FIG. 7B ), showing the steady, synchronized stepwise inflation of the balloon, until the balloon is typically inflated to the desired extent and at is the desired location. - In some embodiments,
actuator 75 is connected to a typically non-synchronized inflation device. In another embodiment,actuator 75 and the inflation device are integrated together into a single, synchronized inflation device. - Reference is now made to
FIG. 7C , which is a graph showing thepressure 77 of the balloon as a function of time, in accordance with an embodiment of the present invention. - Reference is now made to
FIG. 8 , which is a schematic illustration of apparatus for facilitating the synchronized inflation of aballoon 82, in accordance with an embodiment of the present invention. The operator of the device actuates a handle 81 (such as via rotating), in order to inflateballoon 82.Handle 81, by means ofcontrol circuit 83, commandsdriver 84.Driver 84 is synchronized by a train of pulses 85 (which originates from the ECG as explained previously), such that it produces a synchronous output into a torque motor. The torque motor comprises astator 86 androtor 87. The torque motor rotates alead screw 88.Stationary drive nut 89 converts the rotational motion oflead screw 88 into the linear motion ofpiston 810. The motion ofpiston 810 insidecylinder 811 pushes the fluid contained within the distal portion ofcylinder 811 intoinflation tube 812, and from there intoballoon 82. -
FIGS. 9-11 are schematic illustrations of apparatus for facilitating the synchronized inflation of a balloon, in accordance with another embodiment of the present invention.Inflation device 91 andballoon catheter 92 are typically the same as those conventionally used for non-synchronized balloon inflation. In some embodiments, synchronization of balloon inflation to the patient's cardiac cycle is enabled by an accumulator-modulator 93 that is added and is typically connected betweeninflation device 91 andballoon catheter 92. The output ofinflation device 91, typically in the form of inflation fluid, feeds accumulator-modulator 93. The output of accumulator-modulator 93, typically in the form of inflation fluid, feedsballoon catheter 92. - The purpose of accumulator-
modulator 93 is to enable intermittent balloon inflation that is performed, in whole or in part, in a stepwise manner and in synchronization with the patient's ECG signal. The modulator part of 93 is typically responsible primarily for the synchronization of the inflation to the ECG. The accumulator part of 93 is typically responsible primarily for maintaining a continuous build-up of the inflation pressure despite the inflation itself being (in whole or in part) intermittent. (Without the accumulator, undesirable increases and decreases in the inflation pressure may occur.) -
FIG. 10 is a schematic illustration of an embodiment of accumulator-modulator 93 described with respect toFIG. 9 . The accumulator unit comprises a loadedpiston 101. The modulator unit comprisesvalve 102,driver circuit 103 andinternal power supply 104.Internal power supply 104 is optional, as an alternative to an external power supply.Driver circuit 103 is fed by the ECG-derived synchronization signal vialine 107, and based on that signal drivesvalve 102 to assume the open and closed positions. In an embodiment, the accumulator-modulator receives its input, typically in the form of inflation fluid, from an inflation device viainlet 105. The accumulator-modulator typically provides its output, typically in the form of inflation fluid, to a balloon catheter viaoutlet 106. - As noted above, the modulator unit of the accumulator-modulator described with respect to
FIG. 9 andFIG. 10 typically comprises a valve that opens and shuts in accordance with the ECG-derived synchronization signal and through which the inflation fluid traverses. Such a valve may comprise any known implementation, including a check valve of any type (e.g., ball check, duckbill, swing check, clapper, stop check), a leaf valve, or any combination thereof. -
FIG. 11 is a detailed schematic illustration of the accumulator-modulator described with respect toFIG. 9 andFIG. 10 , in accordance with an embodiment of the present invention. Inflation fluid traversesflexible tube 111 on its way towards the outlet of the accumulator-modulator.Tube 111 changes intermittently between being open and shut for the flow of such fluid. Twoarms 112, pivoting onaxes 115, intermittently squeeze andrelease tube 111. The activation ofcoil 113causes arms 112 to pull closer to one another for minimizing the magnetic field reluctance, and thus squeezetube 111 shut. Whencoil 113 is deactivated, arms 112 (with the assistance of an optional recoil spring 114) pull apart and causetube 111 to open for the passage of inflation fluid. - Reference is now made to
FIG. 12 , which is a schematic illustration of apparatus for facilitating the synchronized inflation of a balloon, the apparatus being built into an inflation device, in accordance with a further embodiment of the present invention. Apressure signal 125 is created byinflation mechanism 126. An ECG-derivedsynchronization signal 121 and pressure signal 125 are both fed intocontroller 122. Asynchronized actuation signal 123 is fed fromcontroller 122 tovalve modulator 124. The output ofvalve modulator 124, typically in the form of inflation fluid, is fed into a balloon catheter that is typically connected distally to the inflation device. As a result, the balloon is inflated gradually, in a stepwise manner, to a desired size. - Each of the aforementioned balloon inflation apparatuses and methods, described with respect to
FIGS. 7 through 12 , may be synchronized either to the patient's ECG signal, blood pressure signal, displacement signal, vibration signal or to a different signal corresponding to the patient's cardiac cycle, or to any combination, derivation, extrapolation or manipulation thereof. - In some embodiments, the aforementioned balloon inflation apparatuses and methods described with respect to
FIGS. 7 through 12 apply not only to the placement and inflation of a balloon, but also to the deployment of a stent which is positioned upon the balloon. Typically, deploying a stent in a virtually stable environment leads to greater accuracy in the placement of the stent at a given location. In some embodiments, other medical tools which are positioned upon the balloon are deployed via the inflation of the balloon. For example, a valve, a graft, a septal-closure device, and/or another medical tool may be deployed via the inflation of the balloon. - In some embodiments, while causing the inflation of the balloon to occur (in whole or in part) in a stepwise manner in synchronization with the ECG signal, the aforementioned balloon inflation apparatus and methods described with respect to
FIGS. 7 through 12 provide the operator of the inflation device with continuous force feedback during inflation. Thus, the operator of the inflation device typically feels as if the balloon inflation process is continuous even though that process, or parts thereof, is in fact intermittent. In some embodiments, the apparatus smoothens the force feedback with respect to the physiological cycle to which the inflation is gated, so that the effect of the stepwise inflation, on the force feedback to the operator, is reduced. - Although embodiments of synchronizing the actuation, and/or the movement of a tool to a physiological cycle, have been described with respect to a balloon, the scope of the invention includes applying these embodiments to the other medical tools described herein.
-
FIGS. 13 through 15 disclose embodiments of the synchronized application of a guide wire, such as for opening an occlusion in a coronary blood vessel, in accordance with an embodiment of the present invention. In some embodiments, application of the guide wire is synchronized either to the patient's ECG signal, or to a different signal corresponding to the patient's cardiac cycle, or to any combination, derivation, extrapolation or manipulation thereof. - Reference is now made to
FIG. 13 , which is a schematic illustration of synchronization of the penetration of anocclusion 132 of ablood vessel 131 with cyclic movement of the blood vessel, in accordance with an embodiment of the present invention. In the case of a total or near-total occlusion, such penetration typically precedes the inflation of a balloon and/or the placement of a stent.Wire 133 penetrates the occlusion in a synchronized, stepwise manner. Anactuator 135, synchronized bysignal 134 coming from the patient's ECG, is used to generate the stepwise forward motion as seen inschematic sequence 136. Typically, such synchronized forward motion of thewire 133 enables these embodiments of the current invention to reduce the probability of perforation or dissection ofblood vessel 131 by the guide wire. Conversely, in conventional procedures, such perforation or dissection is known to occur, typically due to pushing the wire at a phase in the cardiac cycle where the wire actually points at the wall of the vessel and not towards the desired point of entry on the surface of the occlusion. - In some embodiments, synchronization is made to a phase in the cardiac cycle when the coronary arteries are typically maximally inflated and thus with the largest cross section. Such timing may assist in opening the occlusion.
- In some embodiments, the operator feels as if he or she pushes the wire continuously, while the actuator causes the wire to be pushed intermittently, in synchronization with the ECG signal.
- In some embodiments, the aforementioned synchronization is applied to a tool used for widening or opening occlusions, where the tool is not a guide wire. In some embodiments, synchronization is applied to the tool's motion within the occlusion. In some embodiments, an occlusion-opening tool, for example a tool having jackhammer-like functionality, is moved toward the occlusion during the given phase of respective cycles. Typically, after the tool is moved toward the occlusion at the given phase of a first cycle and before the tool is moved toward the occlusion at the given phase of a subsequent cycle the tool is retracted from the occlusion. In another embodiment, synchronization is used to control the release of energy, for example, ultrasonic energy, aimed at widening or opening the occlusion.
- Reference is now made to
FIG. 14 , which is a schematic illustration of a modulator for synchronizing the penetration of an occlusion of a blood vessel by awire 141 with the cyclic movement of the blood vessel, in accordance with an embodiment of the present invention. The modulator generates stepwise motion ofwire 141. The modulator disclosed herein is an embodiment based on a self-lockingclamp 143 driven by a voice coil incorporating acoil plunger 145 and apermanent magnet stator 146. Areturn spring 142 is also incorporated. Other modulators capable of generating periodic motion that are known in the art include, but are not limited to, those based on roller wheels, grippers, or piezoelectric or magnetostrictive effects. The modulator is typically housed in shell orhousing 144.Wire 141 can be placed into the modulator at any desired position along the wire, for example after the interventional cardiologist has already pushed the wire all the way to the occlusion. - In some embodiments, similar modulating heads yield rotational motion of the wire by adding a torque generator to the modulator.
- Reference is now made to
FIG. 15 , which is a schematic illustration of a handheld actuator that comprises the modulator described with respect toFIG. 14 , in accordance with an embodiment of the present invention.Electronic circuit 152 conveys a driving signal tomodulator 153, in the manner already described with respect toFIG. 14 .Control stick 151 controls the motion ofguide wire 155. For example, when the operator pushesstick 151 forward, or activates a trigger, the actuator conveys a corresponding train of pulses tomodulator 153. These pulses are synchronized vialine 154 to the reference signal. The pulse train, when delivered to the modulator, creates the forward motion of the guide wire in a synchronized stepwise manner. Typically, the harder operator pushescontrol stick 151, the more intense are the pulses, hence wire 155 will move forward at a higher pace. By pullingstick 151 backwards, the guide wire will move correspondingly backwards. In some embodiments, the force feedback provided to controlstick 151 is spring loaded. In some embodiments, a force feedback that bears greater resemblance to the original force feedback ofwire 155 is generated. For example, force feedback that does not vary with respect to the cyclic activity of the blood vessel, or force feedback that is smoothened with respect to the movement of the blood vessel, may be generated. - In some embodiments, the operator exerts force on
guide wire 155 directly, and not indirectly viacontrol stick 151 as is described above. - In some embodiments, the actuator provides custom force feedback which typically increases its user-friendliness by providing the operator with a more familiar feel. In some embodiments, the actuator (and specifically the control stick) replicates the tactile feedback of specific medical tools, thus increasing its utility to the operator. In some embodiments, a digital library of tool-specific force feedbacks is connected to the actuator. In some embodiments, the force feedback specific to each tool is selected by the operator. In some embodiments, the force feedback specific to each tool is selected automatically, with the actuator identifying the tool (such as via a specific code).
- In some embodiments, the aforementioned actuator controls the application of:
-
- linear motion,
- angular motion (e.g., for the purpose of turning the tip of the penetrating device and, for example, for leading a drill through an occlusion in a coronary blood vessel synchronized with the cardiac cycle),
- energy (e.g., for radio frequency ablation synchronized with the cardiac cycle, or for percutaneous myocardial revascularization via the application of laser in synchronization with the cardiac cycle),
- substance delivery (e.g., gene therapy for cardiac revascularization synchronized with the cardiac cycle), or
- pressure, such as for inflating a balloon and/or a stent
- any combination thereof.
- In some embodiments, the aforementioned actuator comprises re-usable elements, restricted-reuse elements, single-use elements, or any combination thereof. In some embodiments, the actuator, or elements thereof, are usable only for a specific time period and/or a specific number of uses following their initial activation. In some embodiments, the time period and/or number of uses are coded in a memory element (such as a memory chip) incorporated into the actuator.
- Reference is now made to
FIG. 16 , which is a schematic illustration of the stepwise transluminal placement of acoronary bypass graft 163 in acoronary blood vessel 161 in order to bypass anocclusion 162, in accordance with an embodiment of the present invention. In the prior art, such an implantation is typically performed during open heart surgery. In such surgery, a bypass is implanted between the proximal and distal sides of a major impairment (such as a total occlusion) in a blood vessel. Embodiments of the current invention, by providing a full or partial virtual stabilization as previously explained, make it possible to connect the proximal and distal sides ofimpairment 162 without open surgery. Based on a combination of the stabilized image ofblood vessel 161 and the synchronous activation (based uponsignal 164 and by means of actuator 165) of the tool(s) delivering and placing the graft, the two sides of the impairment are connected transluminally. Typically, images generated from two separate views, sequentially or concurrently (such as those provided concurrently by a bi-plane fluoroscopy system), are used. Such views typically differ from one another by at least 30 degrees, and in some embodiments they are perpendicular. In some embodiments, the graft is a biological graft. Alternatively, the graft is a synthetic graft. - In some embodiments, the aforementioned modulator, modulator-accumulator and/or actuator are not hand held. In some embodiments, the aforementioned modulator, modulator-accumulator or actuator are connected to or operated by a medical robot. In some embodiments, the aforementioned modulator, modulator-accumulator and/or actuator are operated in a remote manner via a communications network (e.g., tele-operation).
- For some applications, the aforementioned techniques are applied to an organ that does not move cyclically, but is cyclically active (such as the brain).
- In some embodiments, the synchronized tools disclosed by the current invention are connected to, or operated by, a medical robot.
- The scope of the present invention includes using the techniques of synchronized actuation of a tool, as described hereinabove, for applications other than those described in detail hereinabove. In general, the techniques can be used in combination with the techniques described hereinabove, for stabilized imaging of a cyclically moving organ. In some embodiments, movement of a tool in a given direction or along a desired pattern is synchronized with a physiological cycle. Typically, the tool is moved in the given direction at a given phase of respective physiological cycles without moving the tool in the opposite direction to the given direction, between movements of the tool in the given direction.
- In some embodiments, a tool is moved in a given direction by moving the center of the tool. In some embodiments, at a given phase of respective cycles of a physiological cycle, a tool is actuated either to perform a function, or to move. For some applications, at a given phase of a single cycle of a physiological cycle, a tool is actuated to mechanically perform a function with respect to a portion of the subject's body that moves as a result of the cycle. For example, the techniques described hereinabove can be applied to the following additional procedures:
-
- Percutaneous placement, replacement or repair of a cardiac valve such as an aortic valve, a mitral valve, a pulmonary valve, or a tricuspid valve. The percutaneous approach may be transvascular or through an incision (such as transapical). It is important to deploy the valve accurately, relative to the surrounding anatomy. Doing so in a beating heart or vessel is often difficult. In accordance with some embodiments of the current invention, a tool carrying a valve is led to, and/or positioned at, and/or actuated to deploy the valve at a desired anatomical location in synchronization with a selected phase of the cardiac cycle. In some embodiments, the selected phase is when the corresponding anatomy is at a peak dimension. In some embodiments, the selected phase of the cycle is when the corresponding anatomy remains stable, or relatively stable, for the longest duration. In some embodiments, the tool and the anatomy are viewed in an image stream that is stabilized at a same selected phase of the cardiac cycle. In some embodiments, the selected phase at which the tool is moved, positioned, activated or applied is the same selected phase at which an observed image stream is stabilized. In some embodiments, the valve is deployed by expanding the valve at the selected phase during a single cycle. Alternatively, the valve is deployed by expanding the valve in a stepwise manner, at the selected phase, during more than one cycle.
- Catheterization of pulmonary arteries, applying the tools and techniques (e.g., guide wire, balloon, stent, occlusion-opening devices) previously described in the context of the coronary arteries. In some embodiments, such a procedure is performed in conjunction with stabilized imaging as described hereinabove. In another embodiment, such a procedure is performed not in conjunction with stabilized imaging, but yet in synchronization with the cardiac cycle, so as to achieve improved deployment of a balloon or a stent, or better penetration of an occlusion.
- Closure of holes in the septal wall, such as patent Foramen Ovale (PFO) and Atrial Septal Defect (ASD), within the cyclically-moving heart. With embodiments of the current invention, a carrier carrying a closure device is led to, and positioned at, a desired anatomical location (such as the site of the hole in the septum) while both carrier and heart anatomy are viewed in an image stream that is typically stabilized at a selected same phase in the cardiac cycle. Next, the closure device is deployed (including its assembly, expansion and/or release from the carrier) at the desired anatomical location in a selected phase of the cardiac cycle. Such a selected phase is typically the same as the phase selected for the stabilization of the image stream. In some embodiments, the closure device is deployed by expanding the closure device at the selected phase during a single cycle. Alternatively, the closure device is deployed by expanding the closure device in a stepwise manner, at the selected phase, during more than one cycle.
- Placement of a stent graft within the cyclically-moving aorta to treat abdominal aortic aneurysms. In accordance with embodiments of the current invention, a carrier carrying a stent graft is led to, and positioned at, a desired anatomical location (such as the site of the aneurysm) while both carrier and aortic anatomy are viewed in an image stream that is typically stabilized at a selected same phase in the cardiac cycle. Next, the stent graft is deployed (including its assembly, expansion and/or release from the carrier) at the desired anatomical location in a selected phase of the cardiac cycle. Such selected phase is typically the same as the phase selected for the stabilization of the image stream. In other embodiments of the current invention, the graft is deployed at the desired anatomical location in a selected phase of the cardiac cycle (such as when the corresponding section of the target vessel is at its peak dimensions), without observing stabilized imaging. In some embodiments, the stent is a self-expansible stent.
- Localized energy application to a tissue, such as within the heart (e.g., cardiac ablation performed by means of radio frequency ablation, cryoablation, laser, electrocautery, or ultrasound to address cardiac arrhythmia). In some embodiments, the current invention facilitates the ablation of endocardial tissue in a desired pattern, such as a continuous line or a series of lines, for example, to apply a Maze procedure to the tissue. In some embodiments, movement of the ablation tool is performed in synchronization with a selected phase in the cardiac cycle. In some embodiments, delivery of energy is performed in synchronization with a selected phase in the cardiac cycle. In some embodiments, the endocardial tissue is observed via an image stream stabilized at a selected phase in the cardiac cycle, and movement and/or activation of an ablation (or other) tool is applied at the same selected phase in the course of a plurality of cardiac cycles.
- Percutaneous myocardial revascularization, such as via creating holes in the heart muscle in a desired pattern and by means of an energy delivery or mechanical penetration tool. In some embodiments, movement of the tool is performed in synchronization with a selected phase in the cardiac cycle. In some embodiments, the tool is actuated (such as to deliver energy or drill a hole) in synchronization with a selected phase in the cardiac cycle. In some embodiments, the endocardial tissue is observed via an image stream stabilized at a selected phase in the cardiac cycle, and movement and/or activation of the tool is applied at the same selected phase in the course of a plurality of cardiac cycles.
- Delivering any material or substance, such as, for example, gene therapy or stem cells to specific locations in the heart muscle. In some embodiments, the current invention facilitates the injection of a substance into the heart muscle in a desired pattern, such as a series of points spread across a surface area. In some embodiments, movement of the tool is performed in synchronization with a selected phase in the cardiac cycle. In some embodiments, delivery of the substance is performed in synchronization with a selected phase in the cardiac cycle. In some embodiments, the endocardial tissue is observed via an image stream stabilized at a selected phase in the cardiac cycle, and movement of the tool and/or delivery of the substance is applied at the same selected phase in the course of a plurality of cardiac cycles.
- Suturing tissue in a cyclically-moving organ, such as in a bypass or a valve or a graft. In some embodiments, movement of the suturing tool is performed in synchronization with a selected phase in the cardiac cycle. In some embodiments, suturing is performed in synchronization with a selected phase in the cardiac cycle. In some embodiments, the endocardial tissue is observed via an image stream stabilized at a selected phase in the cardiac cycle, and movement of the tool and/or suturing is applied at the same selected phase in the course of a plurality of cardiac cycles.
- Trans Thoracic Needle Aspiration (TTNA), such as when a cyclically-moving lesion within the lungs needs to be biopsied (and while avoiding mistaken penetration of life-critical organs). With embodiments of the current invention, an aspiration needle is led to, and positioned at, a desired anatomical location in the thorax (such as a lung lesion) while both the tool and thoracic anatomy are viewed in an image stream (such as CT images) that is typically stabilized at a selected same phase in the respiratory and/or cardiac cycle. Next, aspiration is performed at the desired anatomical location in a selected phase of the cardiac and/or respiratory cycle. The selected phase is typically the same as the phase selected for the stabilization of the image stream.
- Trans Bronchial Needle Aspiration (TBNA) such as when a cyclically-moving lesion within the lungs needs to be biopsied (and while avoiding mistaken penetration of life-critical organs).
- Neural stimulation in the brain with its activation gated with the EEG signal.
- Attaching or placing a tool at a desired location, on or within a cyclically-moving organ.
- Moving or directing a tool to a desired location, on or within a cyclically-moving organ.
- Or any combination thereof.
- It will be appreciated by persons skilled in the art that the present invention is not limited to what has been particularly shown and described hereinabove. Rather, the scope of the present invention includes both combinations and subcombinations of the various features described hereinabove, as well as variations and modifications thereof that are not in the prior art, which would occur to persons skilled in the art upon reading the foregoing description.
Claims (68)
1. Apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus comprising:
an imaging device for acquiring a plurality of image frames of the portion of the subject's body;
a sensor for sensing a phase of the cyclic activity;
a medical tool configured to perform a function with respect to the portion of the subject's body;
a control unit configured to:
generate a stabilized set of image frames of the medical tool disposed within the portion of the subject's body,
actuate the tool to execute an action selected from the group consisting of performing the function and moving, in response to the sensor sensing that the cyclic activity is at a given phase thereof, and
inhibit the tool from executing the action in response to the sensor sensing that the cyclic activity is not at the given phase; and
a display configured to facilitate use of the tool by displaying the stabilized set of image frames of the medical tool disposed within the portion of the subject's body.
2. The apparatus according to claim 1 , further comprising a user interface, wherein the control unit is configured to receive an input from a user, via the user interface, and to designate the given phase in response to the input.
3. The apparatus according to claim 1 , wherein the tool comprises a valve configured to be implanted within the portion of the subject's body by being expanded within the portion, and wherein the control unit is configured to actuate the valve by expanding the valve.
4. The apparatus according to claim 1 , wherein the tool comprises a septal-closure device configured to be implanted within the portion of the subject's body by being expanded within the portion, and wherein the control unit is configured to actuate the septal-closure device by expanding the septal closure device.
5. The apparatus according to claim 1 , wherein the tool comprises a balloon configured to perform the function by being inflated inside a lumen of the portion of the subject's body.
6. The apparatus according to claim 1 , wherein the tool comprises a tubular structure configured to bypass an occlusion of a blood vessel within the portion of the subject's body.
7. The apparatus according to claim 1 , wherein the tool comprises a myocardial revascularization tool configured to sequentially apply a revascularization treatment to respective treatment sites within the portion of the subject's body, wherein the control unit is configured to:
actuate the tool to perform the function by actuating the tool to apply a revascularization treatment to a treatment site, and
move the tool by moving at least a portion of the revascularization tool toward successive treatment sites.
8. The apparatus according to claim 1 , wherein the tool comprises an ablation tool configured to sequentially ablate respective ablation sites within the portion of the subject's body, wherein the control unit is configured to:
actuate the tool to perform the function by actuating the tool to ablate an ablation site, and
move the tool by moving at least a portion of the ablation tool toward successive ablation sites.
9. The apparatus according to claim 1 , wherein the tool comprises an injection tool configured to inject a substance within the portion of the subject's body and wherein the control unit is configured to:
actuate the tool to perform the function by actuating the tool to inject the substance, and
move the tool by moving at least a portion of the tool toward an injection site.
10. The apparatus according to claim 1 , wherein the tool comprises a needle configured to suture tissue within the portion of the subject's body, and wherein the control unit is configured to:
actuate the tool to perform the function by actuating the tool to suture the tissue, and
move the tool by moving the needle toward successive suturing sites.
11. The apparatus according to claim 1 , wherein the tool comprises a needle configured to aspirate tissue from an aspiration site within the portion of the subject's body, and wherein the control unit is configured to:
actuate the needle to perform the function by actuating the needle to aspirate the tissue, and
move the needle by moving the needle toward the aspiration site.
12. The apparatus according to claim 1 , wherein the tool comprises an occlusion-opening tool configured to perform the function by performing an occlusion-opening action on an at least partial occlusion of a lumen of the portion of the subject's body.
13. The apparatus according to claim 12 , wherein the tool is configured to perform the occlusion-opening action by moving toward the occlusion, and wherein after actuating the tool at the given phase of a first cycle and before the actuation of the tool at the given phase of a subsequent cycle, the control unit is configured to retract the tool from the occlusion.
14. The apparatus according to claim 1 , wherein the control unit is configured to generate the stabilized set of image frames by image tracking at least some of the plurality of image frames to reduce imaged motion of the portion of the subject's body associated with the cyclic activity.
15. The apparatus according to claim 14 , wherein the control unit is configured to generate the stabilized set of image frames by generating a set of tracked image frames corresponding to image frames of the portion acquired during the given phase.
16. The apparatus according to claim 1 , wherein the control unit is configured to generate the stabilized set of image frames by generating a set of the image frames corresponding to image frames of the portion acquired during the given phase.
17. The apparatus according to claim 16 , wherein the control unit is configured to reduce imaged motion of the portion of the subject's body associated with motion of the portion of the subject's body by image tracking the set of image frames.
18. The apparatus according to claim 16 , wherein the control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase, by actuating the imaging device to acquire the plurality of image frames only when the cyclic activity is at the given phase.
19. The apparatus according to claim 16 , wherein the imaging device is configured to acquire the plurality of image frames throughout the cyclic activity, and wherein the control unit is configured to generate the set of image frames corresponding to image frames of the portion acquired during the given phase by selecting image frames corresponding to image frames of the portion acquired during the given phase from the plurality of image frames.
20. The apparatus according to claim 16 , wherein the control unit is configured to generate an additional stabilized set of image frames of the portion of the subject's body, by identifying a further given phase of the cyclic activity of the body system, and generating a set of the image frames corresponding to image frames of the portion acquired during the further given phase.
21. The apparatus according to claim 1 , wherein the cyclic activity includes a cardiac cycle of the subject, and wherein the sensor comprises a sensor for sensing a phase of the subject's cardiac cycle.
22. The apparatus according to claim 21 , wherein the given phase includes an end-diastolic phase of the subject's cardiac cycle, and wherein the control unit is configured to generate a stabilized set of the image frames corresponding to image frames of the portion acquired during the end-diastolic phase of the subject's cardiac cycle.
23. The apparatus according to claim 21 , wherein the sensor comprises an image processor configured to sense movement of the portion of the subject's body by comparing image frames of the plurality of image frames to at least one of the plurality of image frames.
24. The apparatus according to claim 1 , wherein the cyclic activity includes a respiratory cycle of the subject, and wherein the sensor comprises a sensor for sensing a phase of the subject's respiratory cycle.
25. The apparatus according to claim 24 , wherein the sensor comprises an image processor configured to sense movement of the portion of the subject's body by comparing image frames of the plurality of image frames to at least one of the plurality of image frames.
26. The apparatus according to claim 1 , further comprising an instrument configured to be operated by a user, wherein the control unit is configured to actuate the tool to perform the function, (a) in response to the sensor sensing that the cyclic activity is at the given phase thereof, and (b) in response to the instrument being operated by the user.
27. The apparatus according to claim 26 , wherein the instrument is configured to provide force feedback to the user that is independent of the cyclic activity.
28. The apparatus according to claim 26 , wherein the instrument is configured to provide force feedback to the user that is smoothened with respect to the cyclic activity.
29. A method for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the method comprising:
inserting a medical tool into the portion of the subject's body, the tool being configured to perform a function;
acquiring a plurality of image frames of the tool disposed within the portion of the subject's body;
sensing a phase of the cyclic activity;
displaying a stabilized set of image frames of the tool disposed within the portion of the subject's body;
facilitated by the displaying of the stabilized set of image frames, actuating the tool to execute an action selected from the group consisting of: performing the function and moving, in response to sensing that the cyclic activity is at a given phase thereof, and
inhibiting the tool from executing the action in response to sensing that the cyclic activity is not at the given phase thereof.
30. The method according to claim 29 , wherein the tool includes a valve configured to be implanted within the portion of the subject's body by being expanded within the portion, and wherein actuating the tool to perform the function comprises expanding the valve.
31. The method according to claim 29 , wherein the tool includes a septal-closure device configured to be implanted within the portion of the subject's body by being expanded within the portion, and wherein actuating the tool to perform the function comprises expanding the septal-closure device.
32. The method according to claim 29 , wherein actuating the tool to perform the function comprises actuating a balloon to be inflated inside a lumen of the portion of the subject's body.
33. The method according to claim 29 , wherein moving the tool comprises moving a tubular structure configured to bypass an occlusion of a blood vessel within the portion of the subject's body.
34. The method according to claim 29 ,
wherein the tool includes a myocardial revascularization tool configured to sequentially apply a revascularization treatment to respective treatment sites within the portion of the subject's body,
wherein actuating the tool to perform the function comprises actuating the tool to apply a revascularization treatment to a treatment site, and
wherein moving the tool comprises moving at least a portion of the revascularization tool toward successive treatment sites.
35. The method according to claim 29 ,
wherein the tool includes an ablation tool configured to sequentially ablate respective ablation sites within the portion of the subject's body,
wherein actuating the tool to perform the function comprises actuating the tool to ablate an ablation site, and
wherein moving the tool comprises moving at least a portion of the ablation tool toward successive ablation sites.
36. The method according to claim 29 ,
wherein the tool includes an injection tool configured to inject a substance within the portion of the subject's body,
wherein actuating the tool to perform the function comprises actuating the tool to inject the substance, and
wherein moving the tool comprises moving at least a portion of the tool toward an injection site.
37. The method according to claim 29 ,
wherein the tool includes a needle configured to suture tissue within the portion of the subject's body,
wherein actuating the tool to perform the function comprises actuating the tool to suture the tissue, and
wherein moving the tool comprises moving the needle toward successive suturing sites.
38. The method according to claim 29 ,
wherein the tool includes a needle configured to aspirate tissue from an aspiration site within the portion of the subject's body,
wherein actuating the tool to perform the function comprises actuating the needle to aspirate the tissue, and
wherein moving the tool comprises moving the needle toward the aspiration site.
39. The method according to claim 29 , wherein actuating the tool to perform the function comprises actuating an occlusion-opening tool to perform an occlusion-opening action on an at least partial occlusion of a lumen of the portion of the subject's body.
40. The method according to claim 39 , wherein actuating the tool to perform the occlusion-opening action comprises moving the tool toward the occlusion, and wherein the method further comprises retracting the tool from the occlusion after actuating the tool at the given phase of a first cycle and before the actuation of the tool at the given phase of a subsequent cycle.
41. The method according to claim 29 , wherein displaying the stabilized set of image frames comprises image tracking at least some of the plurality of image frames to reduce imaged motion of the portion of the subject's body associated with the cyclic activity.
42. The method according to claim 41 , wherein displaying the stabilized set of image frames further comprises generating a set of tracked image frames corresponding to image frames of the portion acquired during the given phase.
43. The method according to claim 29 , wherein displaying the stabilized set of image frames comprises displaying a set of the image frames corresponding to image frames of the portion acquired during the given phase.
44. The method according to claim 43 , wherein displaying the stabilized set of image frames further comprises image tracking the set of image frames to reduce imaged motion of the portion of the subject's body associated with motion of the portion of the subject's body.
45. The method according to claim 43 , wherein acquiring the plurality of image frames comprises acquiring the plurality of image frames only when the cyclic activity is at the given phase, and wherein displaying the set of image frames comprises displaying the plurality of acquired image frames.
46. The method according to claim 43 , wherein acquiring the plurality of image frames comprises acquiring the plurality of image frames throughout the cyclic activity, and wherein displaying the set of image frames comprises selecting image frames corresponding to image frames of the portion acquired during the given phase from the plurality of image frames.
47. The method according to claim 43 , further comprising displaying an additional set of stabilized images by sensing a further given phase of the cyclic activity of the body system, and displaying a set of the image frames corresponding to image frames of the portion acquired during the further given phase.
48. The method according to claim 29 , wherein the cyclic activity includes a cardiac cycle of the subject, and wherein sensing the phase comprises sensing a phase of the subject's cardiac cycle.
49. The method according to claim 48 , wherein the given phase includes an end-diastolic phase of the subject's cardiac cycle, and wherein sensing the phase comprises sensing the end-diastolic phase of the subject's cardiac cycle.
50. The method according to claim 48 , wherein sensing the given phase comprises comparing image frames of the plurality of image frames to at least one of the plurality of image frames.
51. The method according to claim 29 , wherein the cyclic activity includes a respiratory cycle of the subject, and wherein sensing the phase comprises sensing a phase of the subject's respiratory cycle.
52. The method according to claim 51 , wherein sensing the given phase comprises comparing image frames of the plurality of image frames to at least one of the plurality of image frames.
53. The method according to claim 29 , wherein actuating the tool to execute the action comprises actuating the tool to execute the action (a) in response to sensing that the cyclic activity is at the given phase thereof, and (b) in response to an instrument being operated by a user.
54. The method according to claim 53 , further comprising providing force feedback to the user that is independent of the cyclic activity.
55. The method according to claim 53 , further comprising providing force feedback to the user that is smoothened with respect to the cyclic activity.
56. Apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, and for use with an imaging device for acquiring a plurality of image frames of the portion of the subject's body, a sensor for sensing a phase of the cyclic activity, a medical tool configured to perform a function with respect to the portion of the subject's body, and a display configured to facilitate use of the tool by displaying image frames of the portion of the subject's body, the apparatus comprising:
a control unit configured to:
generate a stabilized set of image frames of the portion of the subject's body,
output the stabilized set of image frames to the display,
actuate the tool to perform the function in response to the sensor sensing that the cyclic activity is at a given phase of the cyclic activity, and
inhibit the tool from performing the function in response to the sensor sensing that the cyclic activity is not at the given phase.
57. Apparatus for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the apparatus comprising:
an imaging device for acquiring a plurality of image frames of the portion of the subject's body;
a sensor for sensing a phase of the cyclic activity;
a medical tool configured to mechanically perform an action during a single cycle of the cyclic activity with respect to the portion of the subject's body; and
a control unit configured to:
generate a stabilized set of image frames of the portion of the subject's body, and
actuate the tool to mechanically perform the action in response to the sensor sensing that the cyclic activity is at a given phase thereof.
58. The apparatus according to claim 57 , wherein the control unit is configured to generate the stabilized set of image frames by generating a set of image frames that are stabilized with respect to the given phase of the cyclic activity.
59. The apparatus according to claim 57 , wherein the tool comprises a balloon configured to apposition itself to a lumen of the portion of the subject's body during a single cycle by being inflated, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
60. The apparatus according to claim 57 , wherein the tool comprises a stent configured to be implanted by being expanded inside a lumen of the portion of the subject's body during a single cycle of the cyclic activity, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
61. The apparatus according to claim 57 , wherein the tool comprises a valve configured to be implanted within the portion of the subject's body by mechanically expanding within the portion during a single cycle of the cyclic activity, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
62. The apparatus according to claim 57 , wherein the tool comprises a septal-closure device configured to be implanted within a heart of the subject by mechanically expanding within the heart during a single cycle of cardiac cyclic activity of the subject, in response to the sensor sensing that the cyclic activity is at the given phase thereof.
63. A method for use with a portion of a body of a subject that moves as a result of cyclic activity of a body system of the subject, the method comprising:
acquiring a plurality of image frames of the portion of the subject's body;
sensing a phase of the cyclic activity;
generating a stabilized set of image frames of the portion of the subject's body; and
actuating a tool to mechanically perform an action during a single cycle of the cyclic activity, in response to sensing that the cyclic activity is at a given phase thereof.
64. The method according to claim 63 , wherein generating the stabilized set of image frames comprises generating a set of image frames that are stabilized with respect to the given phase of the cyclic activity.
65. The method according to claim 63 , wherein the tool includes a balloon, and wherein actuating the balloon comprises actuating the balloon to apposition itself to a lumen of the portion of the subject's body during a single cycle by being inflated in response to sensing that the cyclic activity is at the given phase thereof.
66. The method according to claim 63 , wherein the tool includes a stent, and wherein actuating the stent comprises implanting the stent by expanding the stent inside a lumen of the portion of the subject's body during a single cycle of the cyclic activity, in response to sensing that the cyclic activity is at the given phase thereof.
67. The method according to claim 63 , wherein the tool includes a valve, and wherein actuating the valve comprises implanting the valve by expanding the valve inside a lumen of the portion of the subject's body during a single cycle of the cyclic activity, in response to sensing that the cyclic activity is at the given phase thereof.
68. The method according to claim 63 , wherein the tool includes a septal-closure device, and wherein actuating the septal-closure device comprises implanting the septal-closure device within a heart of the subject by expanding the septal-closure device inside the subject's heart during a single cycle of the cyclic activity, in response to sensing that the cyclic activity is at the given phase thereof.
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Cited By (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060084962A1 (en) * | 2004-06-02 | 2006-04-20 | Cryovascular Systems, Inc. | Controllable pressure cryogenic balloon treatment system and method |
US20060258933A1 (en) * | 2005-05-10 | 2006-11-16 | Advanced Clinical Solutions, Inc. | Method of defining a biological target for treatment |
US20090182224A1 (en) * | 1999-05-18 | 2009-07-16 | Mediguide Ltd. | Method and apparatus for invasive device tracking using organ timing signal generated from MPS sensors |
US20100160773A1 (en) * | 2007-03-08 | 2010-06-24 | Sync-Rx, Ltd. | Automatic quantitative vessel analysis at the location of an automatically-detected tool |
US20100168557A1 (en) * | 2008-12-30 | 2010-07-01 | Deno D Curtis | Multi-electrode ablation sensing catheter and system |
DE102009009158A1 (en) * | 2009-02-16 | 2010-09-02 | Siemens Aktiengesellschaft | Medical instrument e.g. aortic valve, localization method, involves finding image of image sequence as reference image, and detecting position of instrument in reference image, where instrument position is assigned to position of landmarks |
US20110054308A1 (en) * | 1999-05-18 | 2011-03-03 | Amit Cohen | Method and system for superimposing virtual anatomical landmarks on an image |
US20110112398A1 (en) * | 2009-11-08 | 2011-05-12 | Paieon Inc. | Apparatus and method for locating a device tip within a volume |
US20110144690A1 (en) * | 2008-05-14 | 2011-06-16 | Onset Medical Corporation | Expandable transapical sheath and method of use |
US20120029504A1 (en) * | 2009-05-13 | 2012-02-02 | Afonso Valtino X | System and method for presenting information representative of lesion formation in tissue during an ablation procedure |
US20120155723A1 (en) * | 2010-12-20 | 2012-06-21 | Deno D Curtis | Determination of cardiac geometry responsive to doppler based imaging of blood flow characteristics |
US20120188352A1 (en) * | 2009-09-07 | 2012-07-26 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Concept of superimposing an intraoperative live image of an operating field with a preoperative image of the operating field |
US20130103064A1 (en) * | 2006-05-12 | 2013-04-25 | Vytronus, Inc. | Integrated ablation and mapping system |
US20130166011A1 (en) * | 2001-09-07 | 2013-06-27 | Gera Strommer | System and method for delivering a stent to a selected position within a lumen |
US8700130B2 (en) | 2007-03-08 | 2014-04-15 | Sync-Rx, Ltd. | Stepwise advancement of a medical tool |
US8855744B2 (en) | 2008-11-18 | 2014-10-07 | Sync-Rx, Ltd. | Displaying a device within an endoluminal image stack |
US8900150B2 (en) | 2008-12-30 | 2014-12-02 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Intracardiac imaging system utilizing a multipurpose catheter |
US9012357B2 (en) | 2009-12-18 | 2015-04-21 | Simbol, Inc. | Lithium extraction composition and method of preparation thereof |
CN104602627A (en) * | 2012-11-13 | 2015-05-06 | 奥林巴斯株式会社 | Medical device |
US9034294B1 (en) | 2009-04-24 | 2015-05-19 | Simbol, Inc. | Preparation of lithium carbonate from lithium chloride containing brines |
US9034295B2 (en) | 2009-04-24 | 2015-05-19 | Simbol, Inc. | Preparation of lithium carbonate from lithium chloride containing brines |
US9051827B1 (en) | 2009-09-02 | 2015-06-09 | Simbol Mining Corporation | Selective removal of silica from silica containing brines |
US9074265B2 (en) | 2010-02-17 | 2015-07-07 | Simbol, Inc. | Processes for preparing highly pure lithium carbonate and other highly pure lithium containing compounds |
EP2896425A1 (en) * | 2014-01-16 | 2015-07-22 | Cook Medical Technologies LLC | Transaortic valve access device |
US9095313B2 (en) | 2008-11-18 | 2015-08-04 | Sync-Rx, Ltd. | Accounting for non-uniform longitudinal motion during movement of an endoluminal imaging probe |
US9101286B2 (en) | 2008-11-18 | 2015-08-11 | Sync-Rx, Ltd. | Apparatus and methods for determining a dimension of a portion of a stack of endoluminal data points |
US9144394B2 (en) | 2008-11-18 | 2015-09-29 | Sync-Rx, Ltd. | Apparatus and methods for determining a plurality of local calibration factors for an image |
WO2015155770A1 (en) | 2014-04-10 | 2015-10-15 | Sync-Rx, Ltd. | Image analysis in the presence of a medical device |
US9173586B2 (en) | 2005-12-06 | 2015-11-03 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing coupling between an electrode and tissue |
US9254163B2 (en) | 2005-12-06 | 2016-02-09 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling for tissue ablation |
US9271782B2 (en) | 2005-12-06 | 2016-03-01 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling of tissue ablation |
US9305334B2 (en) | 2007-03-08 | 2016-04-05 | Sync-Rx, Ltd. | Luminal background cleaning |
US9351698B2 (en) | 2013-03-12 | 2016-05-31 | Lightlab Imaging, Inc. | Vascular data processing and image registration systems, methods, and apparatuses |
US9375164B2 (en) | 2007-03-08 | 2016-06-28 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
US9440054B2 (en) | 2008-05-14 | 2016-09-13 | Onset Medical Corporation | Expandable transapical sheath and method of use |
US9492226B2 (en) | 2005-12-06 | 2016-11-15 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Graphical user interface for real-time RF lesion depth display |
US9610118B2 (en) | 2008-12-31 | 2017-04-04 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and apparatus for the cancellation of motion artifacts in medical interventional navigation |
US9610119B2 (en) | 2005-12-06 | 2017-04-04 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing the formation of a lesion in tissue |
US9613289B2 (en) | 2013-12-02 | 2017-04-04 | Toshiba Medical Systems Corporation | X-ray diagnosis apparatus and image processing apparatus |
US9629571B2 (en) | 2007-03-08 | 2017-04-25 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
EP3200155A1 (en) | 2014-05-14 | 2017-08-02 | Sync-RX, Ltd. | Object identification |
WO2017220703A1 (en) | 2016-06-22 | 2017-12-28 | Sync-Rx, Ltd | Estimating the endoluminal path of an endoluminal device along a lumen |
WO2017221159A1 (en) | 2016-06-22 | 2017-12-28 | Sync-Rx, Ltd. | Updating an indication of a lumen location |
US9855384B2 (en) | 2007-03-08 | 2018-01-02 | Sync-Rx, Ltd. | Automatic enhancement of an image stream of a moving organ and displaying as a movie |
US9888969B2 (en) | 2007-03-08 | 2018-02-13 | Sync-Rx Ltd. | Automatic quantitative vessel analysis |
WO2018067252A1 (en) * | 2016-10-06 | 2018-04-12 | Medtronic Vascular Inc. | System and method for crossing a native heart valve with a guidewire |
US9974509B2 (en) | 2008-11-18 | 2018-05-22 | Sync-Rx Ltd. | Image super enhancement |
CN108135652A (en) * | 2016-04-26 | 2018-06-08 | 奥林巴斯株式会社 | Energy treatment apparatus, disposal system and control device |
US9996921B2 (en) | 2015-05-17 | 2018-06-12 | LIGHTLAB IMAGING, lNC. | Detection of metal stent struts |
US10076301B2 (en) | 2012-12-31 | 2018-09-18 | Volcano Corporation | Devices, systems, and methods for assessment of vessels |
US10105107B2 (en) | 2015-01-08 | 2018-10-23 | St. Jude Medical International Holding S.À R.L. | Medical system having combined and synergized data output from multiple independent inputs |
US10109058B2 (en) | 2015-05-17 | 2018-10-23 | Lightlab Imaging, Inc. | Intravascular imaging system interfaces and stent detection methods |
US10172582B2 (en) | 2015-11-18 | 2019-01-08 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US10190030B2 (en) | 2009-04-24 | 2019-01-29 | Alger Alternative Energy, Llc | Treated geothermal brine compositions with reduced concentrations of silica, iron and lithium |
US10222956B2 (en) | 2015-05-17 | 2019-03-05 | Lightlab Imaging, Inc. | Intravascular imaging user interface systems and methods |
US10362962B2 (en) | 2008-11-18 | 2019-07-30 | Synx-Rx, Ltd. | Accounting for skipped imaging locations during movement of an endoluminal imaging probe |
US10362959B2 (en) | 2005-12-06 | 2019-07-30 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing the proximity of an electrode to tissue in a body |
US10453190B2 (en) | 2015-11-23 | 2019-10-22 | Lightlab Imaging, Inc. | Detection of and validation of shadows in intravascular images |
US10499813B2 (en) | 2014-09-12 | 2019-12-10 | Lightlab Imaging, Inc. | Methods, systems and apparatus for temporal calibration of an intravascular imaging system |
US10531841B2 (en) | 2014-07-15 | 2020-01-14 | Volcano Corporation | Devices, systems, and methods and associated display screens for assessment of vessels with multiple sensing components |
US10555685B2 (en) | 2007-12-28 | 2020-02-11 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and apparatus for determining tissue morphology based on phase angle |
US10593037B2 (en) | 2016-04-14 | 2020-03-17 | Lightlab Imaging, Inc. | Method, apparatus, and system to identify branches of a blood vessel |
US10604414B2 (en) | 2017-06-15 | 2020-03-31 | Energysource Minerals Llc | System and process for recovery of lithium from a geothermal brine |
US10631754B2 (en) | 2016-05-16 | 2020-04-28 | Lightlab Imaging, Inc. | Intravascular absorbable stent detection and diagnostic methods and systems |
US10646198B2 (en) | 2015-05-17 | 2020-05-12 | Lightlab Imaging, Inc. | Intravascular imaging and guide catheter detection methods and systems |
US10716528B2 (en) | 2007-03-08 | 2020-07-21 | Sync-Rx, Ltd. | Automatic display of previously-acquired endoluminal images |
US10748289B2 (en) | 2012-06-26 | 2020-08-18 | Sync-Rx, Ltd | Coregistration of endoluminal data points with values of a luminal-flow-related index |
US20200294213A1 (en) * | 2019-03-12 | 2020-09-17 | GE Precision Healthcare LLC | System and method for simulating bilateral injection of contrast agent into a patient |
US10929702B2 (en) | 2015-09-10 | 2021-02-23 | Sync-Rx, Ltd | Automatic image feature removal |
US11064964B2 (en) | 2007-03-08 | 2021-07-20 | Sync-Rx, Ltd | Determining a characteristic of a lumen by measuring velocity of a contrast agent |
US11064903B2 (en) | 2008-11-18 | 2021-07-20 | Sync-Rx, Ltd | Apparatus and methods for mapping a sequence of images to a roadmap image |
US11197651B2 (en) | 2007-03-08 | 2021-12-14 | Sync-Rx, Ltd. | Identification and presentation of device-to-vessel relative motion |
US11287961B2 (en) | 2015-07-25 | 2022-03-29 | Lightlab Imaging, Inc. | Intravascular data visualization and interface systems and methods |
US11517372B2 (en) | 2005-12-06 | 2022-12-06 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing lesions in tissue |
US11744544B2 (en) | 2014-05-06 | 2023-09-05 | Philips Image Guided Therapy Corporation | Devices, systems, and methods for vessel assessment |
US11828272B2 (en) | 2009-06-24 | 2023-11-28 | Terralithium Llc | Process for producing geothermal power, selective removal of silica and iron from brines, and improved injectivity of treated brines |
Families Citing this family (205)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1949501A (en) * | 1999-12-07 | 2001-06-18 | University Of Utah Research Foundation | Method and apparatus for monitoring dynamic systems using n-dimensional representations of critical functions |
US20070066881A1 (en) | 2005-09-13 | 2007-03-22 | Edwards Jerome R | Apparatus and method for image guided accuracy verification |
EP1924198B1 (en) | 2005-09-13 | 2019-04-03 | Veran Medical Technologies, Inc. | Apparatus for image guided accuracy verification |
US9717468B2 (en) * | 2006-01-10 | 2017-08-01 | Mediguide Ltd. | System and method for positioning an artificial heart valve at the position of a malfunctioning valve of a heart through a percutaneous route |
DE102007061934A1 (en) * | 2007-12-21 | 2009-06-25 | Siemens Aktiengesellschaft | Method for improving the quality of computer tomographic acquisition series by projection data processing and CT system with arithmetic unit |
EP2023812B1 (en) | 2006-05-19 | 2016-01-27 | The Queen's Medical Center | Motion tracking system for real time adaptive imaging and spectroscopy |
US9867530B2 (en) | 2006-08-14 | 2018-01-16 | Volcano Corporation | Telescopic side port catheter device with imaging system and method for accessing side branch occlusions |
WO2008111070A2 (en) * | 2007-03-12 | 2008-09-18 | David Tolkowsky | Devices and methods for performing medical procedures in tree-like luminal structures |
US8364242B2 (en) * | 2007-05-17 | 2013-01-29 | General Electric Company | System and method of combining ultrasound image acquisition with fluoroscopic image acquisition |
US10219780B2 (en) | 2007-07-12 | 2019-03-05 | Volcano Corporation | OCT-IVUS catheter for concurrent luminal imaging |
WO2009009799A1 (en) | 2007-07-12 | 2009-01-15 | Volcano Corporation | Catheter for in vivo imaging |
US9596993B2 (en) | 2007-07-12 | 2017-03-21 | Volcano Corporation | Automatic calibration systems and methods of use |
GB0714940D0 (en) * | 2007-08-01 | 2007-09-12 | Depuy Orthopaedie Gmbh | Image processing |
FR2920084B1 (en) * | 2007-08-24 | 2010-08-20 | Endocontrol | IMAGING SYSTEM FOR MONITORING A SURGICAL TOOL IN AN OPERATIVE FIELD |
US8165361B2 (en) * | 2008-01-14 | 2012-04-24 | General Electric Company | System and method for image based multiple-modality cardiac image alignment |
US9549713B2 (en) | 2008-04-24 | 2017-01-24 | Boston Scientific Scimed, Inc. | Methods, systems, and devices for tissue characterization and quantification using intravascular ultrasound signals |
JP5195907B2 (en) * | 2008-05-14 | 2013-05-15 | コニカミノルタエムジー株式会社 | Dynamic image photographing control device and dynamic image photographing system |
US8218847B2 (en) * | 2008-06-06 | 2012-07-10 | Superdimension, Ltd. | Hybrid registration method |
EP2289047B1 (en) * | 2008-06-25 | 2012-03-07 | Koninklijke Philips Electronics N.V. | Localizing an object of interest in a subject |
US8200466B2 (en) | 2008-07-21 | 2012-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Method for tuning patient-specific cardiovascular simulations |
WO2010061322A1 (en) * | 2008-11-25 | 2010-06-03 | Koninklijke Philips Electronics N.V. | Image provision for registration |
US9405886B2 (en) | 2009-03-17 | 2016-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining cardiovascular information |
WO2011019330A1 (en) * | 2009-08-12 | 2011-02-17 | Thomson Licensing | System and method for region-of-interest-based artifact reduction in image sequences |
CN102711635B (en) * | 2010-01-15 | 2015-06-10 | 意美森公司 | Systems and methods for minimally invasive surgical tools with haptic feedback |
CN102844793B (en) * | 2010-02-22 | 2016-08-17 | 皇家飞利浦电子股份有限公司 | For gating the sparse data reconstruction of X ray CT imaging |
JP5469491B2 (en) * | 2010-03-15 | 2014-04-16 | オムロン株式会社 | Image processing apparatus and image processing method |
WO2011145094A2 (en) | 2010-05-17 | 2011-11-24 | Sync-Rx, Ltd. | Identification and presentation of device-to-vessel relative motion |
US8526694B2 (en) | 2010-05-25 | 2013-09-03 | Siemens Medical Solutions Usa, Inc. | Medical image processing and registration system |
US9763587B2 (en) * | 2010-06-10 | 2017-09-19 | Biosense Webster (Israel), Ltd. | Operator-controlled map point density |
US8693755B2 (en) | 2010-06-17 | 2014-04-08 | Siemens Medical Solutions Usa, Inc. | System for adjustment of image data acquired using a contrast agent to enhance vessel visualization for angiography |
US8381108B2 (en) | 2010-06-21 | 2013-02-19 | Microsoft Corporation | Natural user input for driving interactive stories |
EP2599033B1 (en) | 2010-07-29 | 2021-03-31 | Sync-RX, Ltd. | Co-use of endoluminal data and extraluminal imaging |
US8315812B2 (en) | 2010-08-12 | 2012-11-20 | Heartflow, Inc. | Method and system for patient-specific modeling of blood flow |
US10219787B2 (en) * | 2010-09-29 | 2019-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Respiratory mode (“R-Mode”)—acquisition and display of cardiovascular images to show respiratory effects |
US20120083645A1 (en) * | 2010-10-02 | 2012-04-05 | Varian Medical Systems, Inc. | Ecg-correlated radiotherapy |
US8568326B2 (en) * | 2010-10-13 | 2013-10-29 | Volcano Corporation | Intravascular ultrasound pigtail catheter |
EP2632382B1 (en) * | 2010-10-28 | 2017-09-20 | Fiagon AG Medical Technologies | Navigating attachment for optical devices in medicine, and method |
US8594403B2 (en) * | 2010-11-08 | 2013-11-26 | Siemens Medical Solutions Usa, Inc. | Data management system for use in angiographic X-ray imaging |
US11141063B2 (en) | 2010-12-23 | 2021-10-12 | Philips Image Guided Therapy Corporation | Integrated system architectures and methods of use |
US11040140B2 (en) | 2010-12-31 | 2021-06-22 | Philips Image Guided Therapy Corporation | Deep vein thrombosis therapeutic methods |
US20120184850A1 (en) * | 2011-01-14 | 2012-07-19 | Antonio Gutierrez | Imaging and directed phototherapy catheter |
US8553963B2 (en) | 2011-02-09 | 2013-10-08 | Siemens Medical Solutions Usa, Inc. | Digital subtraction angiography (DSA) motion compensated imaging system |
CN102793547B (en) * | 2011-05-27 | 2015-03-11 | 株式会社东芝 | Image processing apparatus and x-ray diagnosis apparatus |
US9259199B2 (en) * | 2011-05-27 | 2016-02-16 | Kabushiki Kaisha Toshiba | Image processing apparatus and X-ray diagnosis apparatus |
WO2012170448A1 (en) * | 2011-06-05 | 2012-12-13 | The Research Foundation Of State University Of New York | System and method for simulating deployment configuration of an expandable device |
DE102011077406B4 (en) * | 2011-06-10 | 2013-03-21 | Siemens Aktiengesellschaft | Method for locating a movable object and X-ray image recording device |
WO2013003826A1 (en) * | 2011-06-29 | 2013-01-03 | The Regents Of The University Of Michigan | Analysis of temporal changes in registered tomographic images |
US9606209B2 (en) | 2011-08-26 | 2017-03-28 | Kineticor, Inc. | Methods, systems, and devices for intra-scan motion correction |
WO2013033592A1 (en) | 2011-08-31 | 2013-03-07 | Volcano Corporation | Optical-electrical rotary joint and methods of use |
US8849005B2 (en) * | 2011-09-28 | 2014-09-30 | Siemens Aktiengesellschaft | Coronary artery motion modeling |
US9247182B2 (en) * | 2011-10-10 | 2016-01-26 | Eyeview, Inc. | Using cluster computing for generating personalized dynamic videos |
US8953911B1 (en) | 2011-10-28 | 2015-02-10 | Lightlab Imaging, Inc. | Spectroscopic imaging probes, devices, and methods |
WO2013112366A1 (en) * | 2012-01-24 | 2013-08-01 | Siemens Aktiengesellschaft | Method and system for motion estimation model for cardiac and respiratory motion compensation |
JP6101048B2 (en) * | 2012-02-20 | 2017-03-22 | キヤノン株式会社 | Image processing apparatus and image processing method |
US9138165B2 (en) | 2012-02-22 | 2015-09-22 | Veran Medical Technologies, Inc. | Systems, methods and devices for forming respiratory-gated point cloud for four dimensional soft tissue navigation |
JP6104601B2 (en) * | 2012-03-06 | 2017-03-29 | 東芝メディカルシステムズ株式会社 | X-ray diagnostic imaging apparatus and control program |
JP6025349B2 (en) * | 2012-03-08 | 2016-11-16 | キヤノン株式会社 | Image processing apparatus, optical coherence tomography apparatus, image processing method, and optical coherence tomography method |
US9999530B2 (en) | 2012-03-30 | 2018-06-19 | Elliot M. Gerber | Diastolic coronary stent deployment system for precise bifurcation lesion stenting |
US8548778B1 (en) | 2012-05-14 | 2013-10-01 | Heartflow, Inc. | Method and system for providing information from a patient-specific model of blood flow |
US20140086461A1 (en) | 2012-09-25 | 2014-03-27 | The Johns Hopkins University | Method and system for determining time-based index for blood circulation from angiographic imaging data |
JP6096459B2 (en) * | 2012-10-04 | 2017-03-15 | 東芝メディカルシステムズ株式会社 | Ultrasonic diagnostic equipment |
US9292918B2 (en) | 2012-10-05 | 2016-03-22 | Volcano Corporation | Methods and systems for transforming luminal images |
US11272845B2 (en) | 2012-10-05 | 2022-03-15 | Philips Image Guided Therapy Corporation | System and method for instant and automatic border detection |
US10568586B2 (en) | 2012-10-05 | 2020-02-25 | Volcano Corporation | Systems for indicating parameters in an imaging data set and methods of use |
US9324141B2 (en) | 2012-10-05 | 2016-04-26 | Volcano Corporation | Removal of A-scan streaking artifact |
JP2015532536A (en) | 2012-10-05 | 2015-11-09 | デイビッド ウェルフォード, | System and method for amplifying light |
US9307926B2 (en) | 2012-10-05 | 2016-04-12 | Volcano Corporation | Automatic stent detection |
US9858668B2 (en) | 2012-10-05 | 2018-01-02 | Volcano Corporation | Guidewire artifact removal in images |
US10070827B2 (en) | 2012-10-05 | 2018-09-11 | Volcano Corporation | Automatic image playback |
US9286673B2 (en) | 2012-10-05 | 2016-03-15 | Volcano Corporation | Systems for correcting distortions in a medical image and methods of use thereof |
US9367965B2 (en) | 2012-10-05 | 2016-06-14 | Volcano Corporation | Systems and methods for generating images of tissue |
US9840734B2 (en) | 2012-10-22 | 2017-12-12 | Raindance Technologies, Inc. | Methods for analyzing DNA |
JP6129525B2 (en) * | 2012-11-20 | 2017-05-17 | 東芝メディカルシステムズ株式会社 | Image processing apparatus and X-ray diagnostic apparatus |
JP6322210B2 (en) | 2012-12-13 | 2018-05-09 | ボルケーノ コーポレイション | Devices, systems, and methods for targeted intubation |
JP2016504589A (en) | 2012-12-20 | 2016-02-12 | ナサニエル ジェイ. ケンプ, | Optical coherence tomography system reconfigurable between different imaging modes |
WO2014099899A1 (en) | 2012-12-20 | 2014-06-26 | Jeremy Stigall | Smooth transition catheters |
US10939826B2 (en) | 2012-12-20 | 2021-03-09 | Philips Image Guided Therapy Corporation | Aspirating and removing biological material |
EP2934282B1 (en) | 2012-12-20 | 2020-04-29 | Volcano Corporation | Locating intravascular images |
US11406498B2 (en) | 2012-12-20 | 2022-08-09 | Philips Image Guided Therapy Corporation | Implant delivery system and implants |
US10942022B2 (en) | 2012-12-20 | 2021-03-09 | Philips Image Guided Therapy Corporation | Manual calibration of imaging system |
US9383263B2 (en) | 2012-12-21 | 2016-07-05 | Volcano Corporation | Systems and methods for narrowing a wavelength emission of light |
JP2016508757A (en) | 2012-12-21 | 2016-03-24 | ジェイソン スペンサー, | System and method for graphical processing of medical data |
CA2895769A1 (en) | 2012-12-21 | 2014-06-26 | Douglas Meyer | Rotational ultrasound imaging catheter with extended catheter body telescope |
JP2016501623A (en) | 2012-12-21 | 2016-01-21 | アンドリュー ハンコック, | System and method for multipath processing of image signals |
US10191220B2 (en) | 2012-12-21 | 2019-01-29 | Volcano Corporation | Power-efficient optical circuit |
US10058284B2 (en) | 2012-12-21 | 2018-08-28 | Volcano Corporation | Simultaneous imaging, monitoring, and therapy |
US10413317B2 (en) | 2012-12-21 | 2019-09-17 | Volcano Corporation | System and method for catheter steering and operation |
WO2014099760A1 (en) | 2012-12-21 | 2014-06-26 | Mai Jerome | Ultrasound imaging with variable line density |
US9486143B2 (en) | 2012-12-21 | 2016-11-08 | Volcano Corporation | Intravascular forward imaging device |
US9612105B2 (en) | 2012-12-21 | 2017-04-04 | Volcano Corporation | Polarization sensitive optical coherence tomography system |
CN104968279B (en) * | 2013-01-17 | 2018-08-10 | 皇家飞利浦有限公司 | Eliminating to move caused by physiological function in medical image influences |
US10327708B2 (en) | 2013-01-24 | 2019-06-25 | Kineticor, Inc. | Systems, devices, and methods for tracking and compensating for patient motion during a medical imaging scan |
US9717461B2 (en) | 2013-01-24 | 2017-08-01 | Kineticor, Inc. | Systems, devices, and methods for tracking and compensating for patient motion during a medical imaging scan |
US9305365B2 (en) | 2013-01-24 | 2016-04-05 | Kineticor, Inc. | Systems, devices, and methods for tracking moving targets |
WO2014120734A1 (en) | 2013-02-01 | 2014-08-07 | Kineticor, Inc. | Motion tracking system for real time adaptive motion compensation in biomedical imaging |
US9060672B2 (en) * | 2013-02-11 | 2015-06-23 | Definiens Ag | Coregistering images of needle biopsies using multiple weighted landmarks |
US9177378B2 (en) | 2013-02-11 | 2015-11-03 | Definiens Ag | Updating landmarks to improve coregistration as regions of interest are corrected |
US9282916B2 (en) * | 2013-03-01 | 2016-03-15 | Pacesetter, Inc. | Vascular branch characterization |
US10226597B2 (en) | 2013-03-07 | 2019-03-12 | Volcano Corporation | Guidewire with centering mechanism |
US9770172B2 (en) | 2013-03-07 | 2017-09-26 | Volcano Corporation | Multimodal segmentation in intravascular images |
US20140276923A1 (en) | 2013-03-12 | 2014-09-18 | Volcano Corporation | Vibrating catheter and methods of use |
CN105228518B (en) | 2013-03-12 | 2018-10-09 | 火山公司 | System and method for diagnosing coronal microvascular diseases |
US9744034B2 (en) * | 2013-03-12 | 2017-08-29 | St. Jude Medical, Cardiology Division, Inc. | Radiopaque transcatheter valve and anatomical markers |
US11026591B2 (en) | 2013-03-13 | 2021-06-08 | Philips Image Guided Therapy Corporation | Intravascular pressure sensor calibration |
CN105120759B (en) | 2013-03-13 | 2018-02-23 | 火山公司 | System and method for producing image from rotation intravascular ultrasound equipment |
US9301687B2 (en) | 2013-03-13 | 2016-04-05 | Volcano Corporation | System and method for OCT depth calibration |
US10219887B2 (en) | 2013-03-14 | 2019-03-05 | Volcano Corporation | Filters with echogenic characteristics |
CN105208947B (en) | 2013-03-14 | 2018-10-12 | 火山公司 | Filter with echoing characteristic |
US10292677B2 (en) | 2013-03-14 | 2019-05-21 | Volcano Corporation | Endoluminal filter having enhanced echogenic properties |
WO2014171391A1 (en) * | 2013-04-15 | 2014-10-23 | オリンパスメディカルシステムズ株式会社 | Endoscope system |
KR102104534B1 (en) * | 2013-06-12 | 2020-04-27 | 삼성전자주식회사 | X-ray imaging apparatus and x-ray imaging apparatus control method |
GB201313680D0 (en) * | 2013-07-31 | 2014-01-08 | Mbda Uk Ltd | Image processing |
GB201313682D0 (en) | 2013-07-31 | 2013-12-18 | Mbda Uk Ltd | Method and apparatus for tracking an object |
GB201313681D0 (en) | 2013-07-31 | 2014-01-08 | Mbda Uk Ltd | Image processing |
DE102013222230A1 (en) | 2013-10-31 | 2015-04-30 | Fiagon Gmbh | Surgical instrument |
KR102243022B1 (en) * | 2014-03-05 | 2021-04-21 | 삼성메디슨 주식회사 | Method, apparatus and system for outputting information of blood flow included in a region of interest based on selection information |
US10004462B2 (en) | 2014-03-24 | 2018-06-26 | Kineticor, Inc. | Systems, methods, and devices for removing prospective motion correction from medical imaging scans |
CN103892919B (en) * | 2014-03-27 | 2016-03-30 | 中国科学院光电技术研究所 | Based on the microsurgical system that optical coherence tomography guides |
US10026015B2 (en) * | 2014-04-01 | 2018-07-17 | Case Western Reserve University | Imaging control to facilitate tracking objects and/or perform real-time intervention |
US20150305650A1 (en) | 2014-04-23 | 2015-10-29 | Mark Hunter | Apparatuses and methods for endobronchial navigation to and confirmation of the location of a target tissue and percutaneous interception of the target tissue |
US20150305612A1 (en) | 2014-04-23 | 2015-10-29 | Mark Hunter | Apparatuses and methods for registering a real-time image feed from an imaging device to a steerable catheter |
JP6364095B2 (en) * | 2014-05-05 | 2018-07-25 | セント・ジュード・メディカル,カーディオロジー・ディヴィジョン,インコーポレイテッド | System and method for rendering a beating heart motion model |
KR102266904B1 (en) * | 2014-05-09 | 2021-06-18 | 삼성전자주식회사 | Method, apparatus and system for providing medical image |
WO2015172100A1 (en) * | 2014-05-09 | 2015-11-12 | The Regents Of The University Of California | Cardiac phase-resolved non-breath-hold 3-dimensional magnetic resonance angiography |
WO2016014718A1 (en) | 2014-07-23 | 2016-01-28 | Kineticor, Inc. | Systems, devices, and methods for tracking and compensating for patient motion during a medical imaging scan |
EP3185774A1 (en) | 2014-08-28 | 2017-07-05 | Brainlab AG | Breathing phase-based transformation of a static computed tomography |
US9805248B2 (en) | 2014-08-29 | 2017-10-31 | Definiens Ag | Applying pixelwise descriptors to a target image that are generated by segmenting objects in other images |
US9613426B2 (en) * | 2014-10-21 | 2017-04-04 | Toshiba Medical Systems Corporation | Segmentation and matching of structures in medical imaging data |
CN107106130A (en) | 2014-11-14 | 2017-08-29 | 皇家飞利浦有限公司 | Percutaneous coronary intervention (PCI) planning interface and associated equipment, system and method |
WO2016075601A1 (en) | 2014-11-14 | 2016-05-19 | Koninklijke Philips N.V. | Percutaneous coronary intervention (pci) planning interface with pressure data and vessel data and associated devices, systems, and methods |
US10410342B2 (en) * | 2014-12-03 | 2019-09-10 | Koninklijke Philips N.V. | Device-based motion-compensated digital subtraction angiography |
JP2017536213A (en) | 2014-12-08 | 2017-12-07 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Automated identification and classification of intravascular lesions |
EP3229696B1 (en) * | 2014-12-08 | 2020-01-08 | Koninklijke Philips N.V. | Patient education for percutaneous coronary intervention treatments |
EP3229721B1 (en) | 2014-12-08 | 2021-09-22 | Koninklijke Philips N.V. | Interactive cardiac test data systems |
EP3236854B1 (en) * | 2015-02-13 | 2019-11-06 | St. Jude Medical International Holding S.à r.l. | Tracking-based 3d model enhancement |
US9943627B2 (en) * | 2015-03-03 | 2018-04-17 | Yujie Zhou | Method of producing personalized biomimetic drug-eluting coronary stents by 3D-printing |
EP3256048B1 (en) | 2015-05-05 | 2019-02-27 | Boston Scientific Scimed Inc. | Systems and methods with a swellable material disposed over a transducer of an ultrasound imaging system |
WO2016183365A1 (en) * | 2015-05-12 | 2016-11-17 | The Johns Hopkins University | Systems and methods for patient-specific modeling of the heart for prediction of targets for catheter ablation of ventricular tachycardia in patients with implantable cardioverter defibrillators |
KR101797042B1 (en) * | 2015-05-15 | 2017-11-13 | 삼성전자주식회사 | Method and apparatus for synthesizing medical images |
US10943504B2 (en) | 2015-06-25 | 2021-03-09 | Koninklijke Philips N.V. | Interactive intravascular procedure training and associated devices, systems, and methods |
US9943247B2 (en) | 2015-07-28 | 2018-04-17 | The University Of Hawai'i | Systems, devices, and methods for detecting false movements for motion correction during a medical imaging scan |
CN108027959B (en) * | 2015-09-25 | 2022-10-25 | 皇家飞利浦有限公司 | Fluorescence imaging middle and low frame rate spatial flicker removal |
WO2017056007A1 (en) | 2015-09-29 | 2017-04-06 | Imperial Innovations Limited | Devices, systems, and methods for coronary intervention assessment, planning, and treatment based on desired outcome |
JP6640522B2 (en) * | 2015-10-14 | 2020-02-05 | キヤノンメディカルシステムズ株式会社 | Image processing apparatus and X-ray diagnostic apparatus |
WO2017091479A1 (en) | 2015-11-23 | 2017-06-01 | Kineticor, Inc. | Systems, devices, and methods for tracking and compensating for patient motion during a medical imaging scan |
EP3389759B1 (en) * | 2015-12-15 | 2020-10-28 | Corindus, Inc. | System and method for controlling x-ray frame rate of an imaging system |
US9990711B2 (en) * | 2016-01-25 | 2018-06-05 | Accuray Incorporated | Manipulation of a respiratory model via adjustment of parameters associated with model images |
WO2017139621A1 (en) * | 2016-02-12 | 2017-08-17 | Intuitive Surgical Operations, Inc. | Systems and methods for using registered fluoroscopic images in image-guided surgery |
CN108697360A (en) * | 2016-02-16 | 2018-10-23 | 圣犹达医疗用品心脏病学部门有限公司 | The method and system of Electrophysiological mapping is used for using medical image |
US10022101B2 (en) * | 2016-02-29 | 2018-07-17 | General Electric Company | X-ray/intravascular imaging colocation method and system |
WO2017197114A1 (en) | 2016-05-11 | 2017-11-16 | Affera, Inc. | Anatomical model generation |
US11728026B2 (en) | 2016-05-12 | 2023-08-15 | Affera, Inc. | Three-dimensional cardiac representation |
US10650512B2 (en) | 2016-06-14 | 2020-05-12 | The Regents Of The University Of Michigan | Systems and methods for topographical characterization of medical image data |
WO2018023024A1 (en) * | 2016-07-29 | 2018-02-01 | The Regents Of The University Of Colorado, A Body Corporate | Automated tracking of fiducial marker clusters in x-ray images |
US10869644B2 (en) * | 2016-07-30 | 2020-12-22 | Shanghai United Imaging Healthcare Co., Ltd. | Method and system for extracting lower limb vasculature |
WO2018026904A1 (en) | 2016-08-03 | 2018-02-08 | Spence Paul A | Devices, systems and methods to improve placement and prevent heart block with percutaneous aortic valve replacement |
US10638932B2 (en) * | 2016-11-09 | 2020-05-05 | Biosense Webster (Israel) Ltd. | MRI thermography for cardiac lesion assessment |
US10438096B2 (en) | 2016-12-27 | 2019-10-08 | Definiens Ag | Identifying and excluding blurred areas of images of stained tissue to improve cancer scoring |
EP3378403A1 (en) * | 2017-03-20 | 2018-09-26 | Koninklijke Philips N.V. | Contrast injection imaging |
EP3659114B1 (en) * | 2017-07-26 | 2024-03-06 | Canon U.S.A., Inc. | Evaluating cardiac motion using an angiography image |
JP6964309B2 (en) * | 2017-08-23 | 2021-11-10 | 株式会社島津製作所 | Radiation therapy tracking device |
US11471217B2 (en) | 2017-12-11 | 2022-10-18 | Covidien Lp | Systems, methods, and computer-readable media for improved predictive modeling and navigation |
WO2019152846A1 (en) * | 2018-02-02 | 2019-08-08 | Centerline Biomedical, Inc. | Graphical user interface for marking anatomic structures |
US11311196B2 (en) | 2018-02-23 | 2022-04-26 | Boston Scientific Scimed, Inc. | Methods for assessing a vessel with sequential physiological measurements |
WO2019183432A1 (en) | 2018-03-23 | 2019-09-26 | Boston Scientific Scimed, Inc. | Medical device with pressure sensor |
EP3545849A1 (en) * | 2018-03-27 | 2019-10-02 | Koninklijke Philips N.V. | Apparatus, system and method for visualizing a periodically moving anatomy |
WO2019195860A2 (en) | 2018-04-04 | 2019-10-10 | Vdyne, Llc | Devices and methods for anchoring transcatheter heart valve |
JP7138189B2 (en) | 2018-04-06 | 2022-09-15 | ボストン サイエンティフィック サイムド,インコーポレイテッド | Medical device with pressure sensor |
CN112292073A (en) | 2018-04-18 | 2021-01-29 | 波士顿科学国际有限公司 | System for evaluating vessels with continuous physiological measurements |
US20210113101A1 (en) * | 2018-04-19 | 2021-04-22 | The General Hospital Corporation | Method and apparatus for measuring intravascular blood flow using a backscattering contrast |
JP7112077B2 (en) * | 2018-09-03 | 2022-08-03 | 学校法人 久留米大学 | CONTROLLER, CONTROLLER MANUFACTURING METHOD, SIMULATED EXPERIENCE SYSTEM, AND SIMULATED EXPERIENCE METHOD |
JP7308600B2 (en) * | 2018-09-12 | 2023-07-14 | キヤノンメディカルシステムズ株式会社 | Ultrasonic diagnostic device, medical image processing device, and ultrasonic image display program |
CN110893108A (en) * | 2018-09-13 | 2020-03-20 | 佳能医疗系统株式会社 | Medical image diagnosis apparatus, medical image diagnosis method, and ultrasonic diagnosis apparatus |
US10321995B1 (en) | 2018-09-20 | 2019-06-18 | Vdyne, Llc | Orthogonally delivered transcatheter heart valve replacement |
US11278437B2 (en) | 2018-12-08 | 2022-03-22 | Vdyne, Inc. | Compression capable annular frames for side delivery of transcatheter heart valve replacement |
US11071627B2 (en) | 2018-10-18 | 2021-07-27 | Vdyne, Inc. | Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis |
US11344413B2 (en) | 2018-09-20 | 2022-05-31 | Vdyne, Inc. | Transcatheter deliverable prosthetic heart valves and methods of delivery |
US10595994B1 (en) | 2018-09-20 | 2020-03-24 | Vdyne, Llc | Side-delivered transcatheter heart valve replacement |
US11109969B2 (en) | 2018-10-22 | 2021-09-07 | Vdyne, Inc. | Guidewire delivery of transcatheter heart valve |
JP7107182B2 (en) * | 2018-11-13 | 2022-07-27 | 株式会社島津製作所 | radiography equipment |
US11538261B2 (en) * | 2018-12-13 | 2022-12-27 | Verily Life Sciences Llc | Systems and methods for automated cell segmentation and labeling in immunofluorescence microscopy |
US10653522B1 (en) | 2018-12-20 | 2020-05-19 | Vdyne, Inc. | Proximal tab for side-delivered transcatheter heart valve prosthesis |
US11253359B2 (en) | 2018-12-20 | 2022-02-22 | Vdyne, Inc. | Proximal tab for side-delivered transcatheter heart valves and methods of delivery |
US11185409B2 (en) | 2019-01-26 | 2021-11-30 | Vdyne, Inc. | Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis |
US11273032B2 (en) | 2019-01-26 | 2022-03-15 | Vdyne, Inc. | Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis |
WO2020181154A2 (en) | 2019-03-05 | 2020-09-10 | Vdyne, Inc. | Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis |
US11076956B2 (en) | 2019-03-14 | 2021-08-03 | Vdyne, Inc. | Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis |
US10631983B1 (en) | 2019-03-14 | 2020-04-28 | Vdyne, Inc. | Distal subannular anchoring tab for side-delivered transcatheter valve prosthesis |
US11173027B2 (en) | 2019-03-14 | 2021-11-16 | Vdyne, Inc. | Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same |
US10758346B1 (en) | 2019-03-14 | 2020-09-01 | Vdyne, Inc. | A2 clip for side-delivered transcatheter mitral valve prosthesis |
US20200305828A1 (en) * | 2019-03-27 | 2020-10-01 | Shimadzu Corporation | Radiation Image Processing Apparatus and Radiation Image Processing Method |
EP3719749A1 (en) | 2019-04-03 | 2020-10-07 | Fiagon AG Medical Technologies | Registration method and setup |
JP2022530764A (en) | 2019-05-04 | 2022-07-01 | ブイダイン,インコーポレイテッド | Tightening device and method for deploying a laterally delivered artificial heart valve with a native annulus. |
WO2021024314A1 (en) * | 2019-08-02 | 2021-02-11 | 株式会社島津製作所 | Medical treatment assistance device and medical treatment assistance method |
EP4017442A4 (en) | 2019-08-20 | 2023-07-26 | Vdyne, Inc. | Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves |
WO2021035119A1 (en) * | 2019-08-22 | 2021-02-25 | Boston Scientific Scimed, Inc. | Systems and methods for processing electronic medical images to determine enhanced electronic medical images |
US11328485B2 (en) * | 2019-08-23 | 2022-05-10 | Tencent America LLC | Method and apparatus for displaying an augmented-reality image corresponding to a microscope view |
CN114630665A (en) | 2019-08-26 | 2022-06-14 | 维迪内股份有限公司 | Laterally deliverable transcatheter prosthetic valve and methods of delivery and anchoring thereof |
US11234813B2 (en) | 2020-01-17 | 2022-02-01 | Vdyne, Inc. | Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery |
CN111513740B (en) * | 2020-04-13 | 2023-09-12 | 北京东软医疗设备有限公司 | Angiography machine control method, angiography machine control device, electronic device, and storage medium |
US11883610B2 (en) | 2020-08-31 | 2024-01-30 | Covidien Lp | Aspiration systems and methods, and expanding-mouth catheters |
EP4203815A1 (en) * | 2020-08-31 | 2023-07-05 | Covidien LP | Aspiration systems and methods, and expanding-mouth catheters |
US11918241B2 (en) | 2020-08-31 | 2024-03-05 | Covidien Lp | Aspiration systems and methods, and expanding-mouth catheters |
US11896250B2 (en) | 2020-08-31 | 2024-02-13 | Covidien Lp | Aspiration systems and methods, and expanding-mouth catheters |
WO2023192392A1 (en) * | 2022-03-29 | 2023-10-05 | Angiowave Imaging, Llc | System and method for angiographic dose reduction using machine learning |
Citations (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3871360A (en) * | 1973-07-30 | 1975-03-18 | Brattle Instr Corp | Timing biological imaging, measuring, and therapeutic timing systems |
US4016871A (en) * | 1975-03-06 | 1977-04-12 | Peter Schiff | Electronic synchronizer-monitor system for controlling the timing of mechanical assistance and pacing of the heart |
US4245647A (en) * | 1978-12-06 | 1981-01-20 | General Electric Company | Arrhythmia rejection circuit for gated cardiac image display systems |
US4316218A (en) * | 1980-03-28 | 1982-02-16 | The United States Of America Government As Represented By The Secretary Of The Army | Video tracker |
US4712560A (en) * | 1985-08-09 | 1987-12-15 | General Electric Company | Apparatus and method of acquiring physiological gating signals for magnetic resonance imaging of moving objects |
US4723938A (en) * | 1986-12-24 | 1988-02-09 | Schneider-Shiley (Usa) Inc. | Single plunger inflation device for angioplasty catheter |
US4920413A (en) * | 1989-02-28 | 1990-04-24 | Olympus Optical Co., Ltd. | Blood-vessel endoscope system for storing a frozen picture in synchronization with heart pulsation |
US4991589A (en) * | 1987-09-22 | 1991-02-12 | Kabushiki Kaisha Toshiba | Ultrasonic imaging apparatus |
US4994965A (en) * | 1988-11-23 | 1991-02-19 | General Electric Company | Method for reducing motion induced image artifacts in projection imaging |
US5177796A (en) * | 1990-10-19 | 1993-01-05 | International Business Machines Corporation | Image data processing of correlated images |
US5176619A (en) * | 1989-05-05 | 1993-01-05 | Jacob Segalowitz | Heart-assist balloon pump with segmented ventricular balloon |
US5293574A (en) * | 1992-10-23 | 1994-03-08 | General Electric Company | Digital x-ray imaging system with automatic tracking |
US5295846A (en) * | 1992-01-10 | 1994-03-22 | Sumitomo Wiring Systems, Ltd. | Plug-in connector assembly |
US5486192A (en) * | 1994-06-03 | 1996-01-23 | Walinsky; Paul | Cyclic coronary angioplasty system |
US5596990A (en) * | 1995-06-06 | 1997-01-28 | Yock; Paul | Rotational correlation of intravascular ultrasound image with guide catheter position |
US5613492A (en) * | 1995-03-31 | 1997-03-25 | New York University | Method and product for improved images in magnetic resonance imaging using multiple breatholding |
US5619995A (en) * | 1991-11-12 | 1997-04-15 | Lobodzinski; Suave M. | Motion video transformation system and method |
US5885218A (en) * | 1997-11-07 | 1999-03-23 | Scimed Life Systems, Inc. | Method and apparatus for spatial filtering in an intravascular ultrasound imaging system |
US5885244A (en) * | 1997-05-14 | 1999-03-23 | Cordis Corporation & University Of Miami | Synchronous, pulsatile angioplasty system |
US6195445B1 (en) * | 1997-06-30 | 2001-02-27 | Siemens Corporate Research, Inc. | Motion compensation of an image sequence using optimal polyline tracking |
US20010031919A1 (en) * | 1999-05-18 | 2001-10-18 | Mediguide Ltd | Medical imaging and navigation system |
US6370417B1 (en) * | 1998-09-22 | 2002-04-09 | Siemens Akiengesellschaft | Method for positioning a catheter in a vessel, and device for implementing the method |
US6377011B1 (en) * | 2000-01-26 | 2002-04-23 | Massachusetts Institute Of Technology | Force feedback user interface for minimally invasive surgical simulator and teleoperator and other similar apparatus |
US20020049375A1 (en) * | 1999-05-18 | 2002-04-25 | Mediguide Ltd. | Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation |
US20030014100A1 (en) * | 2001-05-08 | 2003-01-16 | Maria Meens Hendrik Jozef | Balloon catheter with stent and method for manufacturing it |
US20030018251A1 (en) * | 2001-04-06 | 2003-01-23 | Stephen Solomon | Cardiological mapping and navigation system |
US20030023141A1 (en) * | 1997-08-21 | 2003-01-30 | Paul Stelzer | Minimally invasive surgery device |
US6532380B1 (en) * | 2000-06-30 | 2003-03-11 | Cedars Sinai Medical Center | Image guidance for coronary stent deployment |
US6538634B1 (en) * | 1998-12-18 | 2003-03-25 | Kent Ridge Digital Labs | Apparatus for the simulation of image-guided surgery |
US6546271B1 (en) * | 1999-10-01 | 2003-04-08 | Bioscience, Inc. | Vascular reconstruction |
US20030069499A1 (en) * | 2001-03-19 | 2003-04-10 | Jean Lienard | Method and device for cardiac radiological examination |
US20040034380A1 (en) * | 2001-06-29 | 2004-02-19 | Woolfson Steven B. | Method and apparatus for resecting and replacing an aortic valve |
US6704593B2 (en) * | 2001-04-19 | 2004-03-09 | Sunnybrook & Women's College Health Centre | Realtime MR scan prescription using physiological information |
US6708052B1 (en) * | 2001-04-11 | 2004-03-16 | Harbor Ucla Research And Education Institute | Method and apparatus for cardiac imaging with minimized cardiac motion artifact |
US6711436B1 (en) * | 1997-08-08 | 2004-03-23 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
US6718055B1 (en) * | 2000-12-05 | 2004-04-06 | Koninklijke Philips Electronics, N.V. | Temporal and spatial correction for perfusion quantification system |
US20040077941A1 (en) * | 2002-10-21 | 2004-04-22 | Ge Medical Systems Global Technology Company, Llc | Method and system for image improvement with ECG gating and dose reduction in CT imaging |
US6726675B1 (en) * | 1998-03-11 | 2004-04-27 | Navicath Ltd. | Remote control catheterization |
US6728566B1 (en) * | 2001-11-21 | 2004-04-27 | Koninklijke Philips Electronics, N.V. | Vessel tracking and tree extraction method and apparatus |
US20040097805A1 (en) * | 2002-11-19 | 2004-05-20 | Laurent Verard | Navigation system for cardiac therapies |
US20050004503A1 (en) * | 1998-09-01 | 2005-01-06 | Samson Wilfred J. | Method and apparatus for treating acute myocardial infarction with hypothermic perfusion |
US20050008210A1 (en) * | 2000-05-09 | 2005-01-13 | Paieon, Inc. | System and method for three-dimensional reconstruction of an artery |
US20050031176A1 (en) * | 2003-08-08 | 2005-02-10 | Hertel Sarah R. | Method and apparatus of multi-modality image fusion |
US20050033199A1 (en) * | 2001-08-31 | 2005-02-10 | Van Der Steen Antonius Franciscus Wilhelmus | Three-dimensional tissue hardness imaging |
US6858003B2 (en) * | 1998-11-20 | 2005-02-22 | Intuitive Surgical, Inc. | Performing cardiac surgery without cardioplegia |
US20050043614A1 (en) * | 2003-08-21 | 2005-02-24 | Huizenga Joel T. | Automated methods and systems for vascular plaque detection and analysis |
US20050054916A1 (en) * | 2003-09-05 | 2005-03-10 | Varian Medical Systems Technologies, Inc. | Systems and methods for gating medical procedures |
US20050080336A1 (en) * | 2002-07-22 | 2005-04-14 | Ep Medsystems, Inc. | Method and apparatus for time gating of medical images |
US20050090737A1 (en) * | 2003-10-22 | 2005-04-28 | Burrell Marc A. | Method, apparatus and product for acquiring cardiac images |
US20050096589A1 (en) * | 2003-10-20 | 2005-05-05 | Yehoshua Shachar | System and method for radar-assisted catheter guidance and control |
US20050228359A1 (en) * | 2004-04-07 | 2005-10-13 | Doyle Aiden J | Method and apparatus for treating acute stroke |
US6996430B1 (en) * | 1999-08-16 | 2006-02-07 | Super Dimension Ltd | Method and system for displaying cross-sectional images of a body |
US6999852B2 (en) * | 1992-01-21 | 2006-02-14 | Sri International | Flexible robotic surgery system and method |
US20060058647A1 (en) * | 1999-05-18 | 2006-03-16 | Mediguide Ltd. | Method and system for delivering a medical device to a selected position within a lumen |
US20060074285A1 (en) * | 2004-09-24 | 2006-04-06 | Paieon Inc. | Apparatus and method for fusion and in-operating-room presentation of volumetric data and 3-D angiographic data |
US20060120581A1 (en) * | 2002-10-10 | 2006-06-08 | Kai Eck | Image processing unit and method of associating stored images with current images |
US20070038061A1 (en) * | 2005-06-24 | 2007-02-15 | Volcano Corporation | Three dimensional co-registration for intravascular diagnosis and therapy |
US20070038081A1 (en) * | 2003-09-04 | 2007-02-15 | Koninklijke Philips Electronics N.V. | Device and method for displaying ultrasound images of a vessel |
US7180976B2 (en) * | 2002-06-04 | 2007-02-20 | Koninklijke Philips Electronics N.V. | Rotational angiography based hybrid 3-D reconstruction of coronary arterial structure |
US20070043292A1 (en) * | 2005-08-08 | 2007-02-22 | Siemens Aktiengesellschaft | Method for acquiring and evaluating vascular examination data |
US20070055128A1 (en) * | 2005-08-24 | 2007-03-08 | Glossop Neil D | System, method and devices for navigated flexible endoscopy |
US20070053558A1 (en) * | 2005-09-06 | 2007-03-08 | Pie Medical Imaging B.V. | Method, apparatus and computer program for contour detection of vessels using x-ray densitometry |
US7191100B2 (en) * | 1998-10-23 | 2007-03-13 | Varian Medical Systems Technologies, Inc. | Method and system for predictive physiological gating of radiation therapy |
US20070060798A1 (en) * | 2005-09-15 | 2007-03-15 | Hagai Krupnik | System and method for presentation of data streams |
US20080008366A1 (en) * | 2006-06-20 | 2008-01-10 | Vladimir Desh | Simultaneous visualization, analysis and navigation of multi-modality medical imaging data |
US20080015677A1 (en) * | 2006-06-09 | 2008-01-17 | Glossop Neil D | System for image-guided endovascular prosthesis and method for using same |
US20080021331A1 (en) * | 2004-09-29 | 2008-01-24 | Yeda Research And Development Co. Ltd. | Characterization of moving objects in a stationary background |
US7339585B2 (en) * | 2004-07-19 | 2008-03-04 | Pie Medical Imaging B.V. | Method and apparatus for visualization of biological structures with use of 3D position information from segmentation results |
US7343032B2 (en) * | 2005-09-01 | 2008-03-11 | Fujifilm Corporation | Method and apparatus for automatic and dynamic vessel detection |
US20090016587A1 (en) * | 2007-07-09 | 2009-01-15 | Siemens Corporate Research, Inc. | System and method for two-dimensional visualization of temporal phenomena and three dimensional vessel reconstruction |
US20090074284A1 (en) * | 2004-08-31 | 2009-03-19 | Carl Zeiss Microimaging Ais, Inc. | System and method for creating magnified images of a microscope slide |
US20100041949A1 (en) * | 2007-03-12 | 2010-02-18 | David Tolkowsky | Devices and methods for performing medical procedures in tree-like luminal structures |
US7668362B2 (en) * | 2000-05-03 | 2010-02-23 | Aperio Technologies, Inc. | System and method for assessing virtual slide image quality |
US20100054573A1 (en) * | 2008-08-27 | 2010-03-04 | Raja Shekhara | Method and system for delineation of vasculature |
US20100067768A1 (en) * | 2008-09-18 | 2010-03-18 | Siemens Corporate Research, Inc. | Method and System for Physiological Image Registration and Fusion |
US7729743B2 (en) * | 2003-01-07 | 2010-06-01 | Koninklijke Philips Electronics N.V. | Method and arrangement for tracking a medical instrument |
US20110015520A1 (en) * | 2008-03-17 | 2011-01-20 | Koninklijke Philips Electronics N.V. | Perfusion imaging |
US7877132B2 (en) * | 2005-04-26 | 2011-01-25 | Koninklijke Philips Electronics N.V. | Medical viewing system and method for detecting and enhancing static structures in noisy images using motion of the image acquisition means |
US20110026786A1 (en) * | 2009-07-31 | 2011-02-03 | Siemens Corporation | Method and system for facilitating an image guided medical procedure |
US20110033094A1 (en) * | 2008-04-17 | 2011-02-10 | Michael Zarkh | Method and apparatus for navigating a therapeutic device to a location |
US7889905B2 (en) * | 2005-05-23 | 2011-02-15 | The Penn State Research Foundation | Fast 3D-2D image registration method with application to continuously guided endoscopy |
US20110052030A1 (en) * | 2009-09-03 | 2011-03-03 | Herbert Bruder | Iterative ct image filter for noise reduction |
US20110071404A1 (en) * | 2009-09-23 | 2011-03-24 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US7916912B2 (en) * | 2006-09-14 | 2011-03-29 | Siemens Israel Ltd. | Efficient border extraction of image feature |
US20120004533A1 (en) * | 2010-05-03 | 2012-01-05 | Slemens Corporation | Optimization of multiple candidates in medical device or feature tracking |
US20120004529A1 (en) * | 2007-03-08 | 2012-01-05 | Sync-Rx, Ltd. | Automatic display of previously-acquired endoluminal images |
US20120004537A1 (en) * | 2007-03-08 | 2012-01-05 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
US20120014574A1 (en) * | 2010-07-13 | 2012-01-19 | Sigrid Ferschel | Method for Determining Properties of a Vessel in a Medical Image |
US20120029339A1 (en) * | 2010-07-29 | 2012-02-02 | Sync-Rx, Ltd. | Accounting for forward motion during pullback of an endoluminal imaging probe |
US20120051606A1 (en) * | 2010-08-24 | 2012-03-01 | Siemens Information Systems Ltd. | Automated System for Anatomical Vessel Characteristic Determination |
US20120059253A1 (en) * | 2010-06-29 | 2012-03-08 | Siemens Aktiengesellschaft | Method and System for Image Based Device Tracking for Co-registration of Angiography and Intravascular Ultrasound Images |
US20120059220A1 (en) * | 2010-08-20 | 2012-03-08 | Troy Holsing | Apparatus and method for four dimensional soft tissue navigation in endoscopic applications |
US20120065507A1 (en) * | 2010-09-09 | 2012-03-15 | Siemens Medical Solutions Usa, Inc. | Reduction of motion artifacts in ultrasound imaging with a flexible ultrasound transducer |
US20120069167A1 (en) * | 2009-05-18 | 2012-03-22 | Koninklijke Philips Electronics N.V. | Marker-free tracking registration and calibration for em-tracked endoscopic system |
US20120072190A1 (en) * | 2010-09-16 | 2012-03-22 | Siemens Corporation | Method and System for Non-Invasive Assessment of Coronary Artery Disease |
US20130004044A1 (en) * | 2011-06-29 | 2013-01-03 | The Regents Of The University Of Michigan | Tissue Phasic Classification Mapping System and Method |
US8364242B2 (en) * | 2007-05-17 | 2013-01-29 | General Electric Company | System and method of combining ultrasound image acquisition with fluoroscopic image acquisition |
US20130046167A1 (en) * | 2011-08-17 | 2013-02-21 | Volcano Corporation | Systems and Methods for Identifying Vascular Borders |
US20130053664A1 (en) * | 2010-01-29 | 2013-02-28 | Edwards Lifesciences Corporation | Elimination of the effects of irregular cardiac cycles in the determination of cardiovascular parameters |
US8396276B2 (en) * | 2009-10-26 | 2013-03-12 | Boston Scientific Scimed, Inc. | Systems and methods for performing an image-based gating procedure during an IVUS imaging procedure |
Family Cites Families (341)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2273505A1 (en) | 1974-06-07 | 1976-01-02 | Inst Nat Sante Rech Med | RESPIRATORY AND HEART CYCLE CORRELATION DEVICE, AND APPLICATION TO HEART RATE MEASUREMENT |
US3954098A (en) | 1975-01-31 | 1976-05-04 | Dick Donald E | Synchronized multiple image tomographic cardiography |
US4382184A (en) | 1978-11-24 | 1983-05-03 | Cardiac Imaging Limited Partnership | Apparatus and method for simultaneously displaying relative displacements of a fluctuating biological object |
US4270143A (en) | 1978-12-20 | 1981-05-26 | General Electric Company | Cross-correlation video tracker and method |
US4545390A (en) | 1982-09-22 | 1985-10-08 | C. R. Bard, Inc. | Steerable guide wire for balloon dilatation procedure |
EP0193712B1 (en) | 1985-02-04 | 1990-04-25 | Siemens Aktiengesellschaft | X-ray diagnostic system for subtraction angiography |
US4741328A (en) * | 1985-03-14 | 1988-05-03 | Shlomo Gabbay | Means for intraaortic assist and method of positioning a catheter therefor |
IL76397A0 (en) | 1985-09-13 | 1986-01-31 | Elscint Ltd | System for decision making and implementation in imaging systems |
US4770184A (en) | 1985-12-17 | 1988-09-13 | Washington Research Foundation | Ultrasonic doppler diagnostic system using pattern recognition |
US4758223A (en) | 1986-07-02 | 1988-07-19 | Schneider-Shiley (Usa) Inc. | Inflation device for angioplasty catheter |
US4849906A (en) | 1987-08-24 | 1989-07-18 | Hughes Aircraft Company | Dual mode video tracker |
US4878115A (en) | 1987-09-25 | 1989-10-31 | University Of Kentucky Research Foundation | Dynamic coronary roadmapping |
US5020516A (en) | 1988-03-31 | 1991-06-04 | Cardiopulmonary Corporation | Circulatory assist method and apparatus |
JPH02114776A (en) | 1988-10-25 | 1990-04-26 | Toshiba Corp | X-ray diagnostic device |
DE3914619A1 (en) * | 1989-05-03 | 1990-11-08 | Kontron Elektronik | DEVICE FOR TRANSOESOPHAGEAL ECHOCARDIOGRAPHY |
US5062056A (en) | 1989-10-18 | 1991-10-29 | Hughes Aircraft Company | Apparatus and method for tracking a target |
US5150292A (en) | 1989-10-27 | 1992-09-22 | Arch Development Corporation | Method and system for determination of instantaneous and average blood flow rates from digital angiograms |
US5457754A (en) | 1990-08-02 | 1995-10-10 | University Of Cincinnati | Method for automatic contour extraction of a cardiac image |
US5457728A (en) | 1990-11-14 | 1995-10-10 | Cedars-Sinai Medical Center | Coronary tracking display |
US5054045A (en) | 1990-11-14 | 1991-10-01 | Cedars-Sinai Medical Center | Coronary tracking display |
US5054492A (en) | 1990-12-17 | 1991-10-08 | Cardiovascular Imaging Systems, Inc. | Ultrasonic imaging catheter having rotational image correlation |
US5330496A (en) | 1991-05-06 | 1994-07-19 | Alferness Clifton A | Vascular catheter assembly for tissue penetration and for cardiac stimulation and methods thereof |
JP3167367B2 (en) | 1991-09-09 | 2001-05-21 | 株式会社東芝 | Cardiovascular diagnostic device |
US5537490A (en) | 1992-06-04 | 1996-07-16 | Matsushita Electric Industrial Co., Ltd. | Line image processing method |
US5429144A (en) * | 1992-10-30 | 1995-07-04 | Wilk; Peter J. | Coronary artery by-pass method |
US5792157A (en) | 1992-11-13 | 1998-08-11 | Scimed Life Systems, Inc. | Expandable intravascular occlusion material removal devices and methods of use |
US5357956A (en) | 1992-11-13 | 1994-10-25 | American Cardiac Ablation Co., Inc. | Apparatus and method for monitoring endocardial signal during ablation |
DK0797988T3 (en) | 1993-07-19 | 2009-05-11 | Univ British Columbia | Anti-angiogenic compositions and methods for their use |
US5423806A (en) * | 1993-10-01 | 1995-06-13 | Medtronic, Inc. | Laser extractor for an implanted object |
US6120523A (en) | 1994-02-24 | 2000-09-19 | Radiance Medical Systems, Inc. | Focalized intraluminal balloons |
US5538494A (en) | 1994-03-17 | 1996-07-23 | Hitachi, Ltd. | Radioactive beam irradiation method and apparatus taking movement of the irradiation area into consideration |
DE4413458C2 (en) | 1994-04-18 | 1997-03-27 | Siemens Ag | X-ray diagnostic device for subtraction angiography |
US5573012A (en) | 1994-08-09 | 1996-11-12 | The Regents Of The University Of California | Body monitoring and imaging apparatus and method |
US6246898B1 (en) | 1995-03-28 | 2001-06-12 | Sonometrics Corporation | Method for carrying out a medical procedure using a three-dimensional tracking and imaging system |
US5577502A (en) | 1995-04-03 | 1996-11-26 | General Electric Company | Imaging of interventional devices during medical procedures |
DE69638011D1 (en) | 1995-10-13 | 2009-10-08 | Medtronic Vascular Inc | NGRIFF |
US5807327A (en) | 1995-12-08 | 1998-09-15 | Ethicon, Inc. | Catheter assembly |
US6915149B2 (en) | 1996-01-08 | 2005-07-05 | Biosense, Inc. | Method of pacing a heart using implantable device |
US5971976A (en) | 1996-02-20 | 1999-10-26 | Computer Motion, Inc. | Motion minimization and compensation system for use in surgical procedures |
US20070208388A1 (en) | 1996-04-30 | 2007-09-06 | Jahns Scott E | Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure |
US7269457B2 (en) | 1996-04-30 | 2007-09-11 | Medtronic, Inc. | Method and system for vagal nerve stimulation with multi-site cardiac pacing |
US5916194A (en) | 1996-05-24 | 1999-06-29 | Sarcos, Inc. | Catheter/guide wire steering apparatus and method |
US5764723A (en) | 1996-10-16 | 1998-06-09 | The Trustees Of Columbia University In The City Of New York | Apparatus and method to gate a source for radiation therapy |
US6331181B1 (en) | 1998-12-08 | 2001-12-18 | Intuitive Surgical, Inc. | Surgical robotic tools, data architecture, and use |
US5809105A (en) | 1997-03-19 | 1998-09-15 | General Electric Company | Noise filter for digital x-ray imaging system |
US6095976A (en) | 1997-06-19 | 2000-08-01 | Medinol Ltd. | Method for enhancing an image derived from reflected ultrasound signals produced by an ultrasound transmitter and detector inserted in a bodily lumen |
DE69833665T2 (en) * | 1997-08-08 | 2006-11-09 | Duke University | COMPOSITIONS FOR SIMPLIFYING SURGICAL PROCEDURES |
US6148095A (en) | 1997-09-08 | 2000-11-14 | University Of Iowa Research Foundation | Apparatus and method for determining three-dimensional representations of tortuous vessels |
EP2362285B1 (en) | 1997-09-19 | 2015-03-25 | Massachusetts Institute of Technology | Robotic apparatus |
US5876343A (en) | 1997-09-23 | 1999-03-02 | Scimed Life Systems, Inc. | Methods and apparatus for blood speckle detection in an intravascular ultrasound imaging system |
US5921934A (en) | 1997-11-25 | 1999-07-13 | Scimed Life Systems, Inc. | Methods and apparatus for non-uniform rotation distortion detection in an intravascular ultrasound imaging system |
US20030129750A1 (en) | 1998-02-05 | 2003-07-10 | Yitzhack Schwartz | Homing of donor cells to a target zone in tissue using active therapeutics or substances |
US6482217B1 (en) | 1998-04-10 | 2002-11-19 | Endicor Medical, Inc. | Neuro thrombectomy catheter |
US6088488A (en) | 1998-04-17 | 2000-07-11 | General Electric Company | Vascular imaging with adaptive averaging |
US6493575B1 (en) | 1998-06-04 | 2002-12-10 | Randy J. Kesten | Fluoroscopic tracking enhanced intraventricular catheter system |
US6950689B1 (en) | 1998-08-03 | 2005-09-27 | Boston Scientific Scimed, Inc. | Dynamically alterable three-dimensional graphical model of a body region |
EP1115328A4 (en) | 1998-09-24 | 2004-11-10 | Super Dimension Ltd | System and method for determining the location of a catheter during an intra-body medical procedure |
US6233478B1 (en) | 1998-09-28 | 2001-05-15 | Advanced Research & Technology Institute | Apparatus and method for constructing computed tomography image slices of an object undergoing cyclic motion |
US6368345B1 (en) | 1998-09-30 | 2002-04-09 | Edwards Lifesciences Corporation | Methods and apparatus for intraluminal placement of a bifurcated intraluminal garafat |
US6937696B1 (en) * | 1998-10-23 | 2005-08-30 | Varian Medical Systems Technologies, Inc. | Method and system for predictive physiological gating |
US6973202B2 (en) | 1998-10-23 | 2005-12-06 | Varian Medical Systems Technologies, Inc. | Single-camera tracking of an object |
US7450229B2 (en) * | 1999-01-25 | 2008-11-11 | Amnis Corporation | Methods for analyzing inter-cellular phenomena |
US7914442B1 (en) | 1999-03-01 | 2011-03-29 | Gazdzinski Robert F | Endoscopic smart probe and method |
US6424885B1 (en) | 1999-04-07 | 2002-07-23 | Intuitive Surgical, Inc. | Camera referenced control in a minimally invasive surgical apparatus |
US6278767B1 (en) | 1999-04-28 | 2001-08-21 | General Electric Company | Methods for measuring curved distances on 3D and MIP images |
US7778688B2 (en) * | 1999-05-18 | 2010-08-17 | MediGuide, Ltd. | System and method for delivering a stent to a selected position within a lumen |
US6126608A (en) | 1999-05-18 | 2000-10-03 | Pie Medical Equipment B.V. | Portable ultrasound diagnostic system with handsfree display |
US20020058869A1 (en) | 1999-05-19 | 2002-05-16 | Oskar Axelsson | Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials |
JP3668865B2 (en) * | 1999-06-21 | 2005-07-06 | 株式会社日立製作所 | Surgical device |
US6709427B1 (en) * | 1999-08-05 | 2004-03-23 | Kensey Nash Corporation | Systems and methods for delivering agents into targeted tissue of a living being |
US6442415B1 (en) | 1999-08-12 | 2002-08-27 | Magnetic Moments, L.L.C. | Contrast-enhanced coronary artery and coronary artery bypass graft imaging using an aortic root catheter injection with either magnetic resonance angiography or computed tomographic angiography |
US7942888B2 (en) | 1999-09-13 | 2011-05-17 | Rex Medical, L.P. | Vascular hole closure device |
DE19946948A1 (en) | 1999-09-30 | 2001-04-05 | Philips Corp Intellectual Pty | Method and arrangement for determining the position of a medical instrument |
WO2001024114A1 (en) | 1999-09-30 | 2001-04-05 | Koninklijke Philips Electronics N.V. | Image processing method and system for following a moving object in an image sequence |
US20040215235A1 (en) | 1999-11-16 | 2004-10-28 | Barrx, Inc. | Methods and systems for determining physiologic characteristics for treatment of the esophagus |
US6510337B1 (en) | 1999-11-26 | 2003-01-21 | Koninklijke Philips Electronics, N.V. | Multi-phase cardiac imager |
US20020193686A1 (en) * | 2000-01-10 | 2002-12-19 | Pinhas Gilboa | Methods and systems for performing medical procedures with reference to projective image and with respect to pre-stored images |
US6496716B1 (en) | 2000-02-11 | 2002-12-17 | Anatoly Langer | Method and apparatus for stabilization of angiography images |
US6454715B2 (en) | 2000-04-11 | 2002-09-24 | Scimed Life Systems, Inc. | Methods and apparatus for blood speckle detection in an intravascular ultrasound imaging system |
US8782705B2 (en) * | 2000-04-17 | 2014-07-15 | Lg Electronics Inc. | Information descriptor and extended information descriptor data structures for digital television signals |
US6856827B2 (en) | 2000-04-28 | 2005-02-15 | Ge Medical Systems Global Technology Company, Llc | Fluoroscopic tracking and visualization system |
JP2001324305A (en) | 2000-05-17 | 2001-11-22 | Minolta Co Ltd | Image correspondent position detector and range finder equipped with the same |
US6446357B2 (en) * | 2000-06-30 | 2002-09-10 | Whirlpool Corporation | Fuzzy logic control for an electric clothes dryer |
US6796972B1 (en) * | 2000-07-14 | 2004-09-28 | Edwards Lifesciences Llc | Catheter anchoring balloon structure with irrigation |
DE10040403A1 (en) | 2000-08-18 | 2002-02-28 | Impella Cardiotech Ag | Intracardiac blood pump |
US7031504B1 (en) * | 2000-09-26 | 2006-04-18 | Vital Images, Inc. | Image data based retrospective temporal selection of medical images |
JP2002119502A (en) * | 2000-10-17 | 2002-04-23 | Toshiba Corp | Medical device |
US6980675B2 (en) | 2000-10-18 | 2005-12-27 | Paieon, Inc. | Method for processing images of coronary arteries |
US6643533B2 (en) | 2000-11-28 | 2003-11-04 | Ge Medical Systems Global Technology Company, Llc | Method and apparatus for displaying images of tubular structures |
US7547283B2 (en) | 2000-11-28 | 2009-06-16 | Physiosonics, Inc. | Methods for determining intracranial pressure non-invasively |
US6616596B1 (en) | 2000-11-28 | 2003-09-09 | Abiomed, Inc. | Cardiac assistance systems having multiple layers of inflatable elements |
US6491636B2 (en) | 2000-12-07 | 2002-12-10 | Koninklijke Philips Electronics N.V. | Automated border detection in ultrasonic diagnostic images |
US20020090119A1 (en) | 2001-01-08 | 2002-07-11 | Motoaki Saito | Displaying multiple slice images |
US6816606B2 (en) | 2001-02-21 | 2004-11-09 | Interscope Technologies, Inc. | Method for maintaining high-quality focus during high-throughput, microscopic digital montage imaging |
US6666863B2 (en) | 2001-03-01 | 2003-12-23 | Scimed Life Systems, Inc. | Device and method for percutaneous myocardial revascularization |
DE10117752C1 (en) | 2001-04-09 | 2003-02-27 | Siemens Ag | Magnetic resonance imaging device with a device for movement correction |
US6731973B2 (en) | 2001-06-12 | 2004-05-04 | Ge Medical Systems Information Technologies, Inc. | Method and apparatus for processing physiological data |
US7724928B2 (en) | 2001-06-20 | 2010-05-25 | Given Imaging, Ltd. | Device, system and method for motility measurement and analysis |
JP3996359B2 (en) * | 2001-07-12 | 2007-10-24 | 株式会社日立メディコ | Magnetic resonance imaging system |
US7209779B2 (en) * | 2001-07-17 | 2007-04-24 | Accuimage Diagnostics Corp. | Methods and software for retrospectively gating a set of images |
DE10136160A1 (en) | 2001-07-25 | 2003-02-13 | Philips Corp Intellectual Pty | Method and device for registering two 3D image data sets |
US6592608B2 (en) | 2001-12-07 | 2003-07-15 | Biopsy Sciences, Llc | Bioabsorbable sealant |
US7003161B2 (en) | 2001-11-16 | 2006-02-21 | Mitutoyo Corporation | Systems and methods for boundary detection in images |
US7289652B2 (en) | 2001-11-21 | 2007-10-30 | Koninklijke Philips Electronics, N. V. | Medical viewing system and method for detecting and enhancing structures in noisy images |
WO2003045979A2 (en) * | 2001-11-29 | 2003-06-05 | Therakos, Inc. | Methods for pretreating a subject with extracorporeal photopheresis and/or apoptotic cells |
US6589176B2 (en) | 2001-12-05 | 2003-07-08 | Koninklijke Philips Electronics N.V. | Ultrasonic image stabilization system and method |
WO2003097125A2 (en) * | 2002-05-17 | 2003-11-27 | Case Western Reserve University | Double contrast technique for mri-guided vascular interventions |
CA2485490A1 (en) | 2002-05-17 | 2003-11-27 | Vincent B. Ho | Respiratory referenced imaging |
US7134994B2 (en) | 2002-05-20 | 2006-11-14 | Volcano Corporation | Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition and display |
DE10233668A1 (en) | 2002-07-24 | 2004-02-19 | Siemens Ag | Data record processing method for a data record for capacity describing a tubular vessel in the body and its surroundings defines a working point for a cutting area |
US7359554B2 (en) * | 2002-08-26 | 2008-04-15 | Cleveland Clinic Foundation | System and method for identifying a vascular border |
US7074188B2 (en) | 2002-08-26 | 2006-07-11 | The Cleveland Clinic Foundation | System and method of characterizing vascular tissue |
US7927275B2 (en) * | 2002-08-26 | 2011-04-19 | The Cleveland Clinic Foundation | System and method of aquiring blood-vessel data |
US7545967B1 (en) | 2002-09-18 | 2009-06-09 | Cornell Research Foundation Inc. | System and method for generating composite subtraction images for magnetic resonance imaging |
US6659953B1 (en) * | 2002-09-20 | 2003-12-09 | Acuson Corporation | Morphing diagnostic ultrasound images for perfusion assessment |
US6835177B2 (en) | 2002-11-06 | 2004-12-28 | Sonosite, Inc. | Ultrasonic blood vessel measurement apparatus and method |
AU2003290979A1 (en) | 2002-11-15 | 2004-06-15 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method and device for catheter-based repair of cardiac valves |
WO2004045702A1 (en) * | 2002-11-19 | 2004-06-03 | Nihon University | Balloon catheter and device for injecting medical treatment method |
US7599730B2 (en) | 2002-11-19 | 2009-10-06 | Medtronic Navigation, Inc. | Navigation system for cardiac therapies |
US8521260B2 (en) | 2002-12-02 | 2013-08-27 | Yeda Research And Development Co. Ltd. | Characterization of arteriosclerosis by optical imaging |
WO2004051579A2 (en) * | 2002-12-04 | 2004-06-17 | Philips Intellectual Property & Standards Gmbh | Apparatus and method for assisting the navigation of a catheter in a vessel |
FR2848809B1 (en) | 2002-12-20 | 2005-10-28 | Ge Med Sys Global Tech Co Llc | METHOD FOR AIDING NAVIGATION VASCULAIE FOR X-RAY FLUOROSCOPY DEVICE |
US20040133129A1 (en) | 2003-01-03 | 2004-07-08 | Mindguard Ltd. | Measurements in a body lumen using guidewire with spaced markers |
US7155046B2 (en) | 2003-02-12 | 2006-12-26 | Pie Medical Imaging Bv | Method of determining physical parameters of bodily structures |
US7330573B2 (en) | 2003-02-21 | 2008-02-12 | Koninklijke Philips Electronics, N.V. | Visualization of medical images |
ATE441360T1 (en) | 2003-02-25 | 2009-09-15 | Koninkl Philips Electronics Nv | INTRAVASCULAR IMAGING |
JP4421203B2 (en) | 2003-03-20 | 2010-02-24 | 株式会社東芝 | Luminous structure analysis processing device |
DE10319546A1 (en) | 2003-04-30 | 2004-11-25 | Siemens Ag | Automatic vein structure anomaly detection procedure recognises vein structure in tomography data, prepares skeletal path and classifies by comparison with characteristic values |
US7171257B2 (en) * | 2003-06-11 | 2007-01-30 | Accuray Incorporated | Apparatus and method for radiosurgery |
US7628785B2 (en) * | 2003-06-13 | 2009-12-08 | Piezo Technologies | Endoscopic medical treatment involving acoustic ablation |
US7822461B2 (en) | 2003-07-11 | 2010-10-26 | Siemens Medical Solutions Usa, Inc. | System and method for endoscopic path planning |
CN1846231A (en) | 2003-07-21 | 2006-10-11 | 派昂公司 | Method and system for identifying optimal image within a series of images that depict a moving organ |
US7398116B2 (en) | 2003-08-11 | 2008-07-08 | Veran Medical Technologies, Inc. | Methods, apparatuses, and systems useful in conducting image guided interventions |
EP1658588A1 (en) | 2003-08-21 | 2006-05-24 | Philips Intellectual Property & Standards GmbH | Device and method for combined display of angiograms and current x-ray images |
US7935055B2 (en) | 2003-09-19 | 2011-05-03 | Siemens Medical Solutions Usa, Inc. | System and method of measuring disease severity of a patient before, during and after treatment |
JP4580628B2 (en) | 2003-09-19 | 2010-11-17 | 株式会社東芝 | X-ray image diagnostic apparatus and image data generation method |
WO2005031635A1 (en) | 2003-09-25 | 2005-04-07 | Paieon, Inc. | System and method for three-dimensional reconstruction of a tubular organ |
US7015473B2 (en) | 2003-09-30 | 2006-03-21 | General Electric Company | Method and apparatus for internal feature reconstruction |
US20060259137A1 (en) | 2003-10-06 | 2006-11-16 | Jason Artof | Minimally invasive valve replacement system |
US7697974B2 (en) | 2003-10-10 | 2010-04-13 | Ge Medical Systems Global Technology Company, Llc | Methods and apparatus for analysis of angiographic and other cyclical images |
JP2005122351A (en) | 2003-10-15 | 2005-05-12 | Seiko Epson Corp | Method, system and program for searching for face image candidate area |
CA2449080A1 (en) | 2003-11-13 | 2005-05-13 | Centre Hospitalier De L'universite De Montreal - Chum | Apparatus and method for intravascular ultrasound image segmentation: a fast-marching method |
WO2005051452A2 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Polymer compositions and methods for their use |
FR2862786B1 (en) | 2003-11-21 | 2006-01-06 | Ge Med Sys Global Tech Co Llc | METHOD FOR ELASTICALLY REPRESENTING AN IMAGE APPLIED TO DIGITALIZED SUBTRACT ANGIOGRAPHY |
DE10354496B4 (en) | 2003-11-21 | 2011-03-31 | Siemens Ag | Medical examination and / or treatment system |
US7313259B2 (en) | 2003-11-26 | 2007-12-25 | General Electric Company | Method, system and computer program product for multi-modality registration using virtual cursors |
EP1691666B1 (en) | 2003-12-12 | 2012-05-30 | University of Washington | Catheterscope 3d guidance and interface system |
US20050137661A1 (en) | 2003-12-19 | 2005-06-23 | Sra Jasbir S. | Method and system of treatment of cardiac arrhythmias using 4D imaging |
US20050143777A1 (en) | 2003-12-19 | 2005-06-30 | Sra Jasbir S. | Method and system of treatment of heart failure using 4D imaging |
US7966058B2 (en) | 2003-12-31 | 2011-06-21 | General Electric Company | System and method for registering an image with a representation of a probe |
US7215802B2 (en) | 2004-03-04 | 2007-05-08 | The Cleveland Clinic Foundation | System and method for vascular border detection |
DE102004011156A1 (en) | 2004-03-08 | 2005-10-06 | Siemens Ag | Method for endoluminal imaging with movement correction |
US7811294B2 (en) | 2004-03-08 | 2010-10-12 | Mediguide Ltd. | Automatic guidewire maneuvering system and method |
JP4795658B2 (en) | 2004-03-23 | 2011-10-19 | 富士フイルム株式会社 | Difference image acquisition method, difference image acquisition device, and program thereof |
US7085342B2 (en) | 2004-04-22 | 2006-08-01 | Canamet Canadian National Medical Technologies Inc | Method for tracking motion phase of an object for correcting organ motion artifacts in X-ray CT systems |
US7397935B2 (en) | 2004-05-10 | 2008-07-08 | Mediguide Ltd. | Method for segmentation of IVUS image sequences |
US8528565B2 (en) | 2004-05-28 | 2013-09-10 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Robotic surgical system and method for automated therapy delivery |
CN100583155C (en) | 2004-06-18 | 2010-01-20 | 皇家飞利浦电子股份有限公司 | Artifact reduction |
JP2008506188A (en) | 2004-07-09 | 2008-02-28 | ジェスチャーラド インコーポレイテッド | Gesture-based reporting method and system |
EP4197447A1 (en) | 2004-08-16 | 2023-06-21 | Corindus, Inc. | Image-guided navigation for catheter-based interventions |
WO2006024015A1 (en) | 2004-08-24 | 2006-03-02 | The General Hospital Corporation | Method and apparatus for imaging of vessel segments |
US7283654B2 (en) * | 2004-08-26 | 2007-10-16 | Lumeniq, Inc. | Dynamic contrast visualization (DCV) |
TWI279403B (en) * | 2004-10-20 | 2007-04-21 | Eternal Chemical Co Ltd | Cyclobutanetetracarboxylate compound and preparation method thereof |
US7822291B2 (en) | 2004-10-28 | 2010-10-26 | Siemens Medical Solutions Usa, Inc. | Non-rigid multi-modal registration using statistical learning methods |
US7486981B2 (en) | 2004-11-15 | 2009-02-03 | Given Imaging Ltd. | System and method for displaying an image stream |
US7713210B2 (en) | 2004-11-23 | 2010-05-11 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and apparatus for localizing an ultrasound catheter |
WO2006049629A1 (en) | 2004-11-24 | 2006-05-11 | Sunnyside Technologies Inc. | Devices and methods for beating heart cardiac surgeries |
JP5107720B2 (en) | 2004-11-24 | 2012-12-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Multi-feature temporal filtering to improve structure in noisy images |
IL165636A0 (en) | 2004-12-08 | 2006-01-15 | Paieon Inc | Method and apparatus for finding the coronary velocity and flow and related parameters |
US7604631B2 (en) | 2004-12-15 | 2009-10-20 | Boston Scientific Scimed, Inc. | Efficient controlled cryogenic fluid delivery into a balloon catheter and other treatment devices |
EP1835855B1 (en) | 2005-01-11 | 2017-04-05 | Volcano Corporation | Vascular image co-registration |
CA2588002A1 (en) | 2005-01-18 | 2006-07-27 | Traxtal Inc. | Method and apparatus for guiding an instrument to a target in the lung |
US7756308B2 (en) | 2005-02-07 | 2010-07-13 | Stereotaxis, Inc. | Registration of three dimensional image data to 2D-image-derived data |
US7892177B2 (en) | 2005-02-28 | 2011-02-22 | Scimed Life Systems, Inc. | Systems and methods for estimating the length and position of a stent to be applied within a patient |
US8295577B2 (en) | 2005-03-31 | 2012-10-23 | Michael Zarkh | Method and apparatus for guiding a device in a totally occluded or partly occluded tubular organ |
EP1869637A1 (en) | 2005-03-31 | 2007-12-26 | Paieon Inc. | Method and apparatus for positioning a device in a tubular organ |
US20060224232A1 (en) | 2005-04-01 | 2006-10-05 | Trivascular, Inc. | Hybrid modular endovascular graft |
US7542800B2 (en) * | 2005-04-05 | 2009-06-02 | Cardiac Pacemakers, Inc. | Method and apparatus for synchronizing neural stimulation to cardiac cycles |
US8491484B2 (en) | 2005-04-12 | 2013-07-23 | Scimed Life Systems, Inc. | Forward looking imaging guidewire |
US7773787B2 (en) | 2005-04-19 | 2010-08-10 | Siemens Medical Solutions Usa, Inc. | Method and apparatus for detecting blood vessel boundaries using multi-scale mean-shift ray propagation |
US7604601B2 (en) | 2005-04-26 | 2009-10-20 | Biosense Webster, Inc. | Display of catheter tip with beam direction for ultrasound system |
US20060241445A1 (en) | 2005-04-26 | 2006-10-26 | Altmann Andres C | Three-dimensional cardial imaging using ultrasound contour reconstruction |
US20060253024A1 (en) | 2005-04-26 | 2006-11-09 | Altmann Andres C | Software product for three-dimensional cardiac imaging using ultrasound contour reconstruction |
US10143398B2 (en) | 2005-04-26 | 2018-12-04 | Biosense Webster, Inc. | Registration of ultrasound data with pre-acquired image |
US8870779B2 (en) | 2005-04-26 | 2014-10-28 | Biosense Webster, Inc. | Display of two-dimensional ultrasound fan |
WO2006117773A1 (en) | 2005-05-03 | 2006-11-09 | Paieon Inc. | Method and apparatus for positioning a biventrivular pacemaker lead and electrode |
JP2008539905A (en) | 2005-05-06 | 2008-11-20 | エダ リサーチ アンド ディベロップメント カンパニー,リミティド | Imaging and analysis of red blood cell motion in blood vessels associated with the cardiac cycle |
DE102005027951A1 (en) | 2005-06-16 | 2007-01-04 | Siemens Ag | Medical system for introducing a catheter into a vessel |
CA2616037A1 (en) * | 2005-07-21 | 2007-02-01 | The Cleveland Clinic Foundation | Medical oscillating compliance devices and uses thereof |
US20070021816A1 (en) | 2005-07-21 | 2007-01-25 | The Research Foundation Of State University Of New York | Stent vascular intervention device and methods for treating aneurysms |
WO2007015199A2 (en) * | 2005-08-04 | 2007-02-08 | Koninklijke Philips Electronics, N.V. | Motion compensation in functional imaging |
US7740584B2 (en) | 2005-08-16 | 2010-06-22 | The General Electric Company | Method and system for mapping physiology information onto ultrasound-based anatomic structure |
WO2007025266A2 (en) | 2005-08-26 | 2007-03-01 | Envivid Devices, Inc. | Vascular graft marker |
DE102005042328A1 (en) | 2005-09-06 | 2007-03-08 | Siemens Ag | Method for determining the propagation behavior of a contrast agent bolus |
US8167932B2 (en) * | 2005-10-18 | 2012-05-01 | Edwards Lifesciences Corporation | Heart valve delivery system with valve catheter |
US7918793B2 (en) | 2005-10-28 | 2011-04-05 | Biosense Webster, Inc. | Synchronization of ultrasound imaging data with electrical mapping |
US7729746B2 (en) | 2005-11-04 | 2010-06-01 | Siemens Aktiengesellschaft | Three-dimensional co-registration between intravascular and angiographic data |
US7650179B2 (en) | 2005-12-09 | 2010-01-19 | Siemens Aktiengesellschaft | Computerized workflow method for stent planning and stenting procedure |
EP1960965A2 (en) | 2005-12-09 | 2008-08-27 | Koninklijke Philips Electronics N.V. | Model-based flow analysis and visualization |
US20070142907A1 (en) | 2005-12-16 | 2007-06-21 | Micardia Corporation | Adjustable prosthetic valve implant |
US7522701B2 (en) * | 2005-12-20 | 2009-04-21 | General Electric Company | System and method for image composition using position sensors |
JP4509925B2 (en) | 2005-12-27 | 2010-07-21 | 株式会社メガチップス | Image processing apparatus, camera system, image processing method, and moving image display method |
US9717468B2 (en) | 2006-01-10 | 2017-08-01 | Mediguide Ltd. | System and method for positioning an artificial heart valve at the position of a malfunctioning valve of a heart through a percutaneous route |
US8105239B2 (en) | 2006-02-06 | 2012-01-31 | Maui Imaging, Inc. | Method and apparatus to visualize the coronary arteries using ultrasound |
EP2001383A4 (en) | 2006-03-17 | 2011-01-19 | Microcube Llc | Devices and methods for creating continuous lesions |
WO2007113705A1 (en) | 2006-04-03 | 2007-10-11 | Koninklijke Philips Electronics N. V. | Determining tissue surrounding an object being inserted into a patient |
US20070255139A1 (en) | 2006-04-27 | 2007-11-01 | General Electric Company | User interface for automatic multi-plane imaging ultrasound system |
JP4499693B2 (en) | 2006-05-08 | 2010-07-07 | ソニー株式会社 | Image processing apparatus, image processing method, and program |
ES2425241T3 (en) | 2006-05-18 | 2013-10-14 | Elekta Ltd. | Methods and systems of segmentation using reparametrization of limits |
CN101448457B (en) | 2006-05-22 | 2011-03-30 | 皇家飞利浦电子股份有限公司 | Motion-compensated coronary flow from projection imaging |
CN101548296B (en) | 2006-06-16 | 2013-04-24 | 皇家飞利浦电子股份有限公司 | Automated hierarchical splitting of anatomical trees |
US8126289B2 (en) | 2006-06-20 | 2012-02-28 | Ophthalmic Imaging Systems | Device, method and system for automatic montage of segmented retinal images |
WO2008007350A1 (en) | 2006-07-09 | 2008-01-17 | Paieon Inc. | A tool and method for optimal positioning of a device within a tubular organ |
US8911406B2 (en) * | 2006-07-12 | 2014-12-16 | Kensey Nash Corporation | Guide wire exchange catheter system |
US7693349B2 (en) * | 2006-08-15 | 2010-04-06 | General Electric Company | Systems and methods for interactive image registration |
US20080051648A1 (en) * | 2006-08-25 | 2008-02-28 | Suri Jasjit S | Medical image enhancement system |
US8676300B2 (en) * | 2006-09-18 | 2014-03-18 | Mediguide Ltd. | Method and system for navigating through an occluded tubular organ |
CN101523438A (en) * | 2006-10-06 | 2009-09-02 | 皇家飞利浦电子股份有限公司 | Spatial characterization of a structure located within an object by identifying 2D representations of the structure within section planes |
US8029447B2 (en) | 2006-10-10 | 2011-10-04 | Volcano Corporation | Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition including an enhanced dynamically configured graphical display |
US7885441B2 (en) | 2006-10-11 | 2011-02-08 | General Electric Company | Systems and methods for implant virtual review |
US20080146923A1 (en) | 2006-10-20 | 2008-06-19 | General Electric Company | Composite ultrasound 3D intracardiac volume by aggregation of individual ultrasound 3D intracardiac segments |
US8795346B2 (en) * | 2006-11-20 | 2014-08-05 | Boston Scientific Scimed, Inc. | Semi rigid edge protection design for stent delivery system |
US7853058B2 (en) | 2006-11-22 | 2010-12-14 | Toshiba Medical Visualization Systems Europe, Limited | Determining a viewpoint for navigating a virtual camera through a biological object with a lumen |
US8077939B2 (en) | 2006-11-22 | 2011-12-13 | General Electric Company | Methods and systems for enhanced plaque visualization |
EP2086415B1 (en) * | 2006-11-22 | 2011-06-08 | Koninklijke Philips Electronics N.V. | Combining x-ray with intravascularly acquired data |
US8111895B2 (en) * | 2006-12-06 | 2012-02-07 | Siemens Medical Solutions Usa, Inc. | Locally adaptive image enhancement for digital subtraction X-ray imaging |
US8165360B2 (en) | 2006-12-06 | 2012-04-24 | Siemens Medical Solutions Usa, Inc. | X-ray identification of interventional tools |
US7831076B2 (en) | 2006-12-08 | 2010-11-09 | Biosense Webster, Inc. | Coloring electroanatomical maps to indicate ultrasound data acquisition |
US20080146942A1 (en) * | 2006-12-13 | 2008-06-19 | Ep Medsystems, Inc. | Catheter Position Tracking Methods Using Fluoroscopy and Rotational Sensors |
US8187190B2 (en) | 2006-12-14 | 2012-05-29 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for configuration of a pacemaker and for placement of pacemaker electrodes |
US8213676B2 (en) | 2006-12-20 | 2012-07-03 | Ge Inspection Technologies Lp | Inspection apparatus method and apparatus comprising motion responsive control |
US7992100B2 (en) | 2006-12-21 | 2011-08-02 | Sectra Ab | Dynamic slabbing to render views of medical image data |
US8512249B2 (en) | 2006-12-21 | 2013-08-20 | Bracco International Bv | Detection of the detachment of immobilized contrast agent in medical imaging applications |
CN101568942A (en) | 2006-12-29 | 2009-10-28 | 皇家飞利浦电子股份有限公司 | Improved image registration and methods for compensating intraoperative motion in image-guided interventional procedures |
KR101517252B1 (en) | 2007-01-19 | 2015-05-04 | 써니브룩 헬스 사이언시즈 센터 | Scanning mechanisms for imaging probe |
US11197651B2 (en) | 2007-03-08 | 2021-12-14 | Sync-Rx, Ltd. | Identification and presentation of device-to-vessel relative motion |
US9968256B2 (en) | 2007-03-08 | 2018-05-15 | Sync-Rx Ltd. | Automatic identification of a tool |
JP5639764B2 (en) | 2007-03-08 | 2014-12-10 | シンク−アールエックス,リミティド | Imaging and tools for use with moving organs |
US9375164B2 (en) | 2007-03-08 | 2016-06-28 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
US8700130B2 (en) | 2007-03-08 | 2014-04-15 | Sync-Rx, Ltd. | Stepwise advancement of a medical tool |
EP2358269B1 (en) | 2007-03-08 | 2019-04-10 | Sync-RX, Ltd. | Image processing and tool actuation for medical procedures |
US11064964B2 (en) | 2007-03-08 | 2021-07-20 | Sync-Rx, Ltd | Determining a characteristic of a lumen by measuring velocity of a contrast agent |
DE102007013624B4 (en) | 2007-03-21 | 2017-02-09 | Siemens Healthcare Gmbh | Device for positioning a stent that can be deployed for vessel support |
US7778488B2 (en) | 2007-03-23 | 2010-08-17 | Varian Medical Systems International Ag | Image deformation using multiple image regions |
US8064666B2 (en) | 2007-04-10 | 2011-11-22 | Avantis Medical Systems, Inc. | Method and device for examining or imaging an interior surface of a cavity |
DE102007019328A1 (en) | 2007-04-24 | 2008-11-06 | Siemens Ag | Method for the high-resolution representation of filigree vascular implants in angiographic images |
EP2153407A1 (en) | 2007-05-02 | 2010-02-17 | Agency for Science, Technology and Research | Motion compensated image averaging |
DE102007021035A1 (en) | 2007-05-04 | 2008-11-13 | Siemens Ag | Image processing, image visualization and image archiving system for the contra-merging and visualization of coregistered image data |
WO2009009223A2 (en) | 2007-05-19 | 2009-01-15 | The Regents Of The University Of California | Co-registration for dual pet-transrectal ultrasound (pet-trus) prostate imaging |
US8520947B2 (en) | 2007-05-22 | 2013-08-27 | The University Of Western Ontario | Method for automatic boundary segmentation of object in 2D and/or 3D image |
US9173638B2 (en) | 2007-06-04 | 2015-11-03 | Biosense Webster, Inc. | Cardiac mechanical assessment using ultrasound |
JP4934513B2 (en) | 2007-06-08 | 2012-05-16 | 株式会社日立メディコ | Ultrasonic imaging device |
US9596993B2 (en) | 2007-07-12 | 2017-03-21 | Volcano Corporation | Automatic calibration systems and methods of use |
WO2009021179A1 (en) | 2007-08-09 | 2009-02-12 | Volcano Corporation | Controller user interface for a catheter lab intravascular ultrasound system |
WO2009022288A2 (en) | 2007-08-16 | 2009-02-19 | Koninklijke Philips Electronics N. V. | Detecting and darkening method of objects in grey-scale raster images |
US8396533B2 (en) | 2007-08-21 | 2013-03-12 | Siemens Aktiengesellschaft | Method and system for catheter detection and tracking in a fluoroscopic image sequence |
US8086000B2 (en) | 2007-08-27 | 2011-12-27 | Pie Medical Imaging B.V. | Method, apparatus and computer program for quantitative bifurcation analysis on angiographic images |
US8271068B2 (en) | 2007-10-02 | 2012-09-18 | Siemens Aktiengesellschaft | Method for dynamic road mapping |
US8244020B2 (en) * | 2007-10-18 | 2012-08-14 | Siemens Aktiengesellschaft | Method and system for intelligent digital subtraction |
US20090105579A1 (en) | 2007-10-19 | 2009-04-23 | Garibaldi Jeffrey M | Method and apparatus for remotely controlled navigation using diagnostically enhanced intra-operative three-dimensional image data |
US8826918B2 (en) | 2007-11-01 | 2014-09-09 | Goody Products, Inc. | Start, style, and finish hairstyling system |
US20100246910A1 (en) | 2007-11-14 | 2010-09-30 | Koninklijke Philips Electronics N.V. | Method of automatically correcting mis-orientation of medical images |
US9076203B2 (en) | 2007-11-26 | 2015-07-07 | The Invention Science Fund I, Llc | Image guided surgery with dynamic image reconstruction |
EP2238742B1 (en) | 2007-12-25 | 2014-05-14 | Medic Vision - Brain Technologies Ltd. | Noise reduction of images |
US20090171201A1 (en) | 2007-12-31 | 2009-07-02 | Olson Eric S | Method and apparatus for real-time hemodynamic monitoring |
US8165361B2 (en) | 2008-01-14 | 2012-04-24 | General Electric Company | System and method for image based multiple-modality cardiac image alignment |
EP2262423B1 (en) | 2008-03-06 | 2018-01-10 | Covidien LP | Image enhancement and application functionality for medical and other uses |
US7792334B2 (en) | 2008-03-31 | 2010-09-07 | Immersion Corporation | Locating blood vessels |
US8050474B2 (en) | 2008-04-11 | 2011-11-01 | Siemens Medical Solutions Usa, Inc. | System for generation of a composite medical image of vessel structure |
US8260395B2 (en) | 2008-04-18 | 2012-09-04 | Medtronic, Inc. | Method and apparatus for mapping a structure |
US20090264753A1 (en) | 2008-04-22 | 2009-10-22 | General Electric Company | Method & system for multi-modality imaging of sequentially obtained pseudo-steady state data |
WO2009137659A1 (en) | 2008-05-07 | 2009-11-12 | Infraredx, Inc. | Multimodal catheter system and method for intravascular analysis |
US8155411B2 (en) | 2008-07-22 | 2012-04-10 | Pie Medical Imaging B.V. | Method, apparatus and computer program for quantitative bifurcation analysis in 3D using multiple 2D angiographic images |
US8189886B2 (en) | 2008-08-13 | 2012-05-29 | Carestream Health, Inc. | Method for detecting anatomical structures |
EP2344020B1 (en) * | 2008-10-14 | 2020-05-20 | Lightlab Imaging, Inc. | Stent strut detection and related measurement and display using optical coherence tomography |
US8488863B2 (en) | 2008-11-06 | 2013-07-16 | Los Alamos National Security, Llc | Combinational pixel-by-pixel and object-level classifying, segmenting, and agglomerating in performing quantitative image analysis that distinguishes between healthy non-cancerous and cancerous cell nuclei and delineates nuclear, cytoplasm, and stromal material objects from stained biological tissue materials |
US20100123715A1 (en) | 2008-11-14 | 2010-05-20 | General Electric Company | Method and system for navigating volumetric images |
US9101286B2 (en) | 2008-11-18 | 2015-08-11 | Sync-Rx, Ltd. | Apparatus and methods for determining a dimension of a portion of a stack of endoluminal data points |
US9095313B2 (en) | 2008-11-18 | 2015-08-04 | Sync-Rx, Ltd. | Accounting for non-uniform longitudinal motion during movement of an endoluminal imaging probe |
US9144394B2 (en) | 2008-11-18 | 2015-09-29 | Sync-Rx, Ltd. | Apparatus and methods for determining a plurality of local calibration factors for an image |
US10362962B2 (en) | 2008-11-18 | 2019-07-30 | Synx-Rx, Ltd. | Accounting for skipped imaging locations during movement of an endoluminal imaging probe |
US11064903B2 (en) | 2008-11-18 | 2021-07-20 | Sync-Rx, Ltd | Apparatus and methods for mapping a sequence of images to a roadmap image |
US8855744B2 (en) | 2008-11-18 | 2014-10-07 | Sync-Rx, Ltd. | Displaying a device within an endoluminal image stack |
US9974509B2 (en) | 2008-11-18 | 2018-05-22 | Sync-Rx Ltd. | Image super enhancement |
US20100135546A1 (en) | 2008-11-28 | 2010-06-03 | General Electric Company | Landmark guides for registration of multi-modality medical images |
EP2348982B1 (en) | 2008-12-03 | 2020-03-25 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System for determining the positioin of the tip of a medical catheter within the body of a patient |
US9412044B2 (en) | 2009-06-09 | 2016-08-09 | Siemens Aktiengesellschaft | Method of compensation of respiratory motion in cardiac imaging |
US8457374B2 (en) | 2009-06-22 | 2013-06-04 | Siemens Medical Solutions Usa, Inc. | System for detecting catheterization devices |
CN102458554B (en) | 2009-06-23 | 2015-09-30 | 皇家飞利浦电子股份有限公司 | Equipment size during intervention measures to be supported |
AU2010278893B2 (en) | 2009-07-29 | 2014-02-27 | C.R. Bard, Inc. | Tubular filter |
US8909323B2 (en) | 2009-08-06 | 2014-12-09 | Siemens Medical Solutions Usa, Inc. | System for processing angiography and ultrasound image data |
US8483488B2 (en) | 2009-08-07 | 2013-07-09 | Medinol Ltd. | Method and system for stabilizing a series of intravascular ultrasound images and extracting vessel lumen from the images |
US9179888B2 (en) | 2009-08-28 | 2015-11-10 | Dartmouth College | System and method for providing patient registration without fiducials |
US8433115B2 (en) | 2009-09-17 | 2013-04-30 | Siemens Aktiengesellschaft | System and method for multi-image based stent visibility enhancement |
DE102009043069A1 (en) | 2009-09-25 | 2011-04-07 | Siemens Aktiengesellschaft | Visualization method and imaging system |
JP5478328B2 (en) | 2009-09-30 | 2014-04-23 | 富士フイルム株式会社 | Diagnosis support system, diagnosis support program, and diagnosis support method |
WO2011046904A1 (en) | 2009-10-12 | 2011-04-21 | Walacavage Alexander J | Breathing apparatus and associated methods of use |
CA2777562C (en) * | 2009-10-12 | 2016-08-16 | Silicon Valley Medical Instruments, Inc. | Intravascular ultrasound system for co-registered imaging |
US8409098B2 (en) | 2009-10-14 | 2013-04-02 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and apparatus for collection of cardiac geometry based on optical or magnetic tracking |
US9002078B2 (en) | 2009-10-22 | 2015-04-07 | Siemens Aktiengesellschaft | Method and system for shape-constrained aortic valve landmark detection |
US9159130B2 (en) | 2009-10-22 | 2015-10-13 | Koninklijke Philips N.V. | Alignment of an ordered stack of images from a specimen |
US8411927B2 (en) | 2009-10-29 | 2013-04-02 | Siemens Aktiengesellschaft | Marker detection in X-ray images |
US8731642B2 (en) | 2009-11-08 | 2014-05-20 | Paieon Inc. | Apparatus and method for locating a device tip within a volume |
RU2542946C2 (en) | 2009-11-19 | 2015-02-27 | Нокиа Корпорейшн | Method and device for tracking and recognising objects using rotation-invariant descriptors |
US20110150309A1 (en) | 2009-11-27 | 2011-06-23 | University Health Network | Method and system for managing imaging data, and associated devices and compounds |
WO2011069098A1 (en) | 2009-12-03 | 2011-06-09 | Cedars-Sinai Medical Center | Method of determing ischemia using paired stress and rest scans |
US8605976B2 (en) | 2009-12-10 | 2013-12-10 | General Electric Corporation | System and method of detection of optimal angiography frames for quantitative coronary analysis using wavelet-based motion analysis |
JP5645399B2 (en) | 2009-12-18 | 2014-12-24 | キヤノン株式会社 | X-ray image processing apparatus, X-ray image processing method, and computer program |
US9451924B2 (en) | 2009-12-30 | 2016-09-27 | General Electric Company | Single screen multi-modality imaging displays |
JP5795599B2 (en) | 2010-01-13 | 2015-10-14 | コーニンクレッカ フィリップス エヌ ヴェ | Image integration based registration and navigation for endoscopic surgery |
US8548213B2 (en) | 2010-03-16 | 2013-10-01 | Siemens Corporation | Method and system for guiding catheter detection in fluoroscopic images |
DE102010013221B4 (en) | 2010-03-29 | 2012-06-28 | Siemens Aktiengesellschaft | Method for highlighting objects in interventional angiographic examinations and device for carrying out the method |
EP2557998B1 (en) | 2010-04-15 | 2020-12-23 | Koninklijke Philips N.V. | Instrument-based image registration for fusing images with tubular structures |
US9082211B2 (en) | 2010-05-06 | 2015-07-14 | The Regents Of The University Of California | Measurement of blood flow dynamics with X-ray computed tomography: dynamic CT angiography |
WO2011145094A2 (en) | 2010-05-17 | 2011-11-24 | Sync-Rx, Ltd. | Identification and presentation of device-to-vessel relative motion |
US8855396B2 (en) | 2010-05-25 | 2014-10-07 | Siemens Medical Solutions Usa, Inc. | System for detecting an invasive anatomical instrument |
US8157742B2 (en) | 2010-08-12 | 2012-04-17 | Heartflow, Inc. | Method and system for patient-specific modeling of blood flow |
US8787641B2 (en) | 2010-09-02 | 2014-07-22 | Pie Medical Imaging B.V. | Method and apparatus for quantitative analysis of a tree of recursively splitting tubular organs |
JP2012075702A (en) | 2010-10-01 | 2012-04-19 | Fujifilm Corp | Apparatus, method, and program for reconstructing intra-tubular-structure image |
US8515146B2 (en) | 2010-10-26 | 2013-08-20 | Siemens Aktiengesellschaft | Deformable motion correction for stent visibility enhancement |
EP2453408B1 (en) | 2010-11-12 | 2013-06-05 | General Electric Company | Method for processing radiographic images for stenosis detection |
US20120130242A1 (en) | 2010-11-24 | 2012-05-24 | Boston Scientific Scimed, Inc. | Systems and methods for concurrently displaying a plurality of images using an intravascular ultrasound imaging system |
EP2663252A1 (en) | 2011-01-13 | 2013-11-20 | Koninklijke Philips N.V. | Intraoperative camera calibration for endoscopic surgery |
CN103379861B (en) | 2011-02-07 | 2016-08-10 | 皇家飞利浦有限公司 | For providing the medical imaging devices of the graphical representation being accurately positioned supporting intervening equipment in blood vessel intervention program |
WO2012138874A2 (en) | 2011-04-08 | 2012-10-11 | Volcano Corporation | Medical sensing communication system and method |
EP2695137A4 (en) | 2011-04-08 | 2014-08-27 | Volcano Corp | Distributed medical sensing system and method |
CN102842128B (en) | 2011-05-23 | 2016-03-30 | 华硕电脑股份有限公司 | Method for checking object and device thereof |
US9610064B2 (en) | 2011-05-31 | 2017-04-04 | Desmond Adler | Multimodal imaging system, apparatus, and methods |
JP6099640B2 (en) | 2011-06-23 | 2017-03-22 | シンク−アールエックス,リミティド | Lumen background sharpening |
EP2570079B1 (en) | 2011-09-13 | 2017-06-14 | Pie Medical Imaging BV | Method and apparatus for determining optimal 3D reconstruction of an object |
IN2014CN03098A (en) | 2011-10-26 | 2015-07-03 | Koninkl Philips Nv | |
US8849375B2 (en) | 2011-11-01 | 2014-09-30 | Siemens Medical Solutions Usa, Inc. | System for detecting rotation angle of a catheter in an X-ray image |
US8861830B2 (en) | 2011-11-07 | 2014-10-14 | Paieon Inc. | Method and system for detecting and analyzing heart mechanics |
WO2013074800A1 (en) | 2011-11-16 | 2013-05-23 | Volcano Corporation | Medical measuring system and method |
WO2013084345A1 (en) | 2011-12-09 | 2013-06-13 | キヤノン株式会社 | Image acquisition device and adjustment method therefor |
JP2015511736A (en) | 2012-02-27 | 2015-04-20 | アセルサン・エレクトロニク・サナイ・ヴェ・ティジャレット・アノニム・シルケティAselsan Elektronik Sanayi veTicaret Anonim Sirketi | System and method for identifying scale invariant features of object contours on images |
WO2013169814A1 (en) | 2012-05-08 | 2013-11-14 | Angiometrix Corporation | Systems for linear mapping of lumens |
EP2852319B1 (en) | 2012-05-21 | 2017-05-17 | Sync-RX, Ltd. | Co-use of endoluminal data and extraluminal imaging |
JP6134789B2 (en) | 2012-06-26 | 2017-05-24 | シンク−アールエックス,リミティド | Image processing related to flow in luminal organs |
WO2015155770A1 (en) | 2014-04-10 | 2015-10-15 | Sync-Rx, Ltd. | Image analysis in the presence of a medical device |
WO2015173821A1 (en) | 2014-05-14 | 2015-11-19 | Sync-Rx, Ltd. | Object identification |
-
2008
- 2008-03-09 JP JP2009552328A patent/JP5639764B2/en not_active Expired - Fee Related
- 2008-03-09 WO PCT/IL2008/000316 patent/WO2008107905A2/en active Application Filing
- 2008-03-09 EP EP08719941A patent/EP2129284A4/en not_active Withdrawn
- 2008-03-10 US US12/075,244 patent/US20080221442A1/en not_active Abandoned
- 2008-03-10 US US12/075,214 patent/US20080221439A1/en not_active Abandoned
- 2008-03-10 US US12/075,252 patent/US20080221440A1/en not_active Abandoned
-
2009
- 2009-12-31 US US12/650,605 patent/US9855384B2/en active Active
-
2013
- 2013-12-30 US US14/143,121 patent/US20140114333A1/en not_active Abandoned
- 2013-12-30 US US14/143,209 patent/US20140114308A1/en not_active Abandoned
-
2014
- 2014-08-12 JP JP2014164417A patent/JP2015013170A/en active Pending
-
2015
- 2015-06-18 US US14/742,750 patent/US20150283319A1/en not_active Abandoned
Patent Citations (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3871360A (en) * | 1973-07-30 | 1975-03-18 | Brattle Instr Corp | Timing biological imaging, measuring, and therapeutic timing systems |
US4016871A (en) * | 1975-03-06 | 1977-04-12 | Peter Schiff | Electronic synchronizer-monitor system for controlling the timing of mechanical assistance and pacing of the heart |
US4245647A (en) * | 1978-12-06 | 1981-01-20 | General Electric Company | Arrhythmia rejection circuit for gated cardiac image display systems |
US4316218A (en) * | 1980-03-28 | 1982-02-16 | The United States Of America Government As Represented By The Secretary Of The Army | Video tracker |
US4712560A (en) * | 1985-08-09 | 1987-12-15 | General Electric Company | Apparatus and method of acquiring physiological gating signals for magnetic resonance imaging of moving objects |
US4723938A (en) * | 1986-12-24 | 1988-02-09 | Schneider-Shiley (Usa) Inc. | Single plunger inflation device for angioplasty catheter |
US4991589A (en) * | 1987-09-22 | 1991-02-12 | Kabushiki Kaisha Toshiba | Ultrasonic imaging apparatus |
US4994965A (en) * | 1988-11-23 | 1991-02-19 | General Electric Company | Method for reducing motion induced image artifacts in projection imaging |
US4920413A (en) * | 1989-02-28 | 1990-04-24 | Olympus Optical Co., Ltd. | Blood-vessel endoscope system for storing a frozen picture in synchronization with heart pulsation |
US5176619A (en) * | 1989-05-05 | 1993-01-05 | Jacob Segalowitz | Heart-assist balloon pump with segmented ventricular balloon |
US5177796A (en) * | 1990-10-19 | 1993-01-05 | International Business Machines Corporation | Image data processing of correlated images |
US5619995A (en) * | 1991-11-12 | 1997-04-15 | Lobodzinski; Suave M. | Motion video transformation system and method |
US5295846A (en) * | 1992-01-10 | 1994-03-22 | Sumitomo Wiring Systems, Ltd. | Plug-in connector assembly |
US6999852B2 (en) * | 1992-01-21 | 2006-02-14 | Sri International | Flexible robotic surgery system and method |
US5293574A (en) * | 1992-10-23 | 1994-03-08 | General Electric Company | Digital x-ray imaging system with automatic tracking |
US5486192A (en) * | 1994-06-03 | 1996-01-23 | Walinsky; Paul | Cyclic coronary angioplasty system |
US5613492A (en) * | 1995-03-31 | 1997-03-25 | New York University | Method and product for improved images in magnetic resonance imaging using multiple breatholding |
US5724977A (en) * | 1995-06-06 | 1998-03-10 | Cardiovascular Imaging Systems Inc. | Rotational correlation of intravascular ultrasound image with guide catheter position |
US5879305A (en) * | 1995-06-06 | 1999-03-09 | Cardiovascular Imaging Systems, Inc. | Rotational correlation of intravascular ultrasound image with guide catheter position |
US5596990A (en) * | 1995-06-06 | 1997-01-28 | Yock; Paul | Rotational correlation of intravascular ultrasound image with guide catheter position |
US5885244A (en) * | 1997-05-14 | 1999-03-23 | Cordis Corporation & University Of Miami | Synchronous, pulsatile angioplasty system |
US6195445B1 (en) * | 1997-06-30 | 2001-02-27 | Siemens Corporate Research, Inc. | Motion compensation of an image sequence using optimal polyline tracking |
US6711436B1 (en) * | 1997-08-08 | 2004-03-23 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
US20030023141A1 (en) * | 1997-08-21 | 2003-01-30 | Paul Stelzer | Minimally invasive surgery device |
US5885218A (en) * | 1997-11-07 | 1999-03-23 | Scimed Life Systems, Inc. | Method and apparatus for spatial filtering in an intravascular ultrasound imaging system |
US6726675B1 (en) * | 1998-03-11 | 2004-04-27 | Navicath Ltd. | Remote control catheterization |
US20050004503A1 (en) * | 1998-09-01 | 2005-01-06 | Samson Wilfred J. | Method and apparatus for treating acute myocardial infarction with hypothermic perfusion |
US6370417B1 (en) * | 1998-09-22 | 2002-04-09 | Siemens Akiengesellschaft | Method for positioning a catheter in a vessel, and device for implementing the method |
US7191100B2 (en) * | 1998-10-23 | 2007-03-13 | Varian Medical Systems Technologies, Inc. | Method and system for predictive physiological gating of radiation therapy |
US6858003B2 (en) * | 1998-11-20 | 2005-02-22 | Intuitive Surgical, Inc. | Performing cardiac surgery without cardioplegia |
US6538634B1 (en) * | 1998-12-18 | 2003-03-25 | Kent Ridge Digital Labs | Apparatus for the simulation of image-guided surgery |
US7343195B2 (en) * | 1999-05-18 | 2008-03-11 | Mediguide Ltd. | Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation |
US20060058647A1 (en) * | 1999-05-18 | 2006-03-16 | Mediguide Ltd. | Method and system for delivering a medical device to a selected position within a lumen |
US20020049375A1 (en) * | 1999-05-18 | 2002-04-25 | Mediguide Ltd. | Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation |
US20010031919A1 (en) * | 1999-05-18 | 2001-10-18 | Mediguide Ltd | Medical imaging and navigation system |
US6996430B1 (en) * | 1999-08-16 | 2006-02-07 | Super Dimension Ltd | Method and system for displaying cross-sectional images of a body |
US6546271B1 (en) * | 1999-10-01 | 2003-04-08 | Bioscience, Inc. | Vascular reconstruction |
US6377011B1 (en) * | 2000-01-26 | 2002-04-23 | Massachusetts Institute Of Technology | Force feedback user interface for minimally invasive surgical simulator and teleoperator and other similar apparatus |
US7668362B2 (en) * | 2000-05-03 | 2010-02-23 | Aperio Technologies, Inc. | System and method for assessing virtual slide image quality |
US7321677B2 (en) * | 2000-05-09 | 2008-01-22 | Paieon Inc. | System and method for three-dimensional reconstruction of an artery |
US20050008210A1 (en) * | 2000-05-09 | 2005-01-13 | Paieon, Inc. | System and method for three-dimensional reconstruction of an artery |
US6532380B1 (en) * | 2000-06-30 | 2003-03-11 | Cedars Sinai Medical Center | Image guidance for coronary stent deployment |
US6718055B1 (en) * | 2000-12-05 | 2004-04-06 | Koninklijke Philips Electronics, N.V. | Temporal and spatial correction for perfusion quantification system |
US20030069499A1 (en) * | 2001-03-19 | 2003-04-10 | Jean Lienard | Method and device for cardiac radiological examination |
US20030018251A1 (en) * | 2001-04-06 | 2003-01-23 | Stephen Solomon | Cardiological mapping and navigation system |
US6708052B1 (en) * | 2001-04-11 | 2004-03-16 | Harbor Ucla Research And Education Institute | Method and apparatus for cardiac imaging with minimized cardiac motion artifact |
US6704593B2 (en) * | 2001-04-19 | 2004-03-09 | Sunnybrook & Women's College Health Centre | Realtime MR scan prescription using physiological information |
US20030014100A1 (en) * | 2001-05-08 | 2003-01-16 | Maria Meens Hendrik Jozef | Balloon catheter with stent and method for manufacturing it |
US20040034380A1 (en) * | 2001-06-29 | 2004-02-19 | Woolfson Steven B. | Method and apparatus for resecting and replacing an aortic valve |
US20050033199A1 (en) * | 2001-08-31 | 2005-02-10 | Van Der Steen Antonius Franciscus Wilhelmus | Three-dimensional tissue hardness imaging |
US6728566B1 (en) * | 2001-11-21 | 2004-04-27 | Koninklijke Philips Electronics, N.V. | Vessel tracking and tree extraction method and apparatus |
US7180976B2 (en) * | 2002-06-04 | 2007-02-20 | Koninklijke Philips Electronics N.V. | Rotational angiography based hybrid 3-D reconstruction of coronary arterial structure |
US20050080336A1 (en) * | 2002-07-22 | 2005-04-14 | Ep Medsystems, Inc. | Method and apparatus for time gating of medical images |
US20060120581A1 (en) * | 2002-10-10 | 2006-06-08 | Kai Eck | Image processing unit and method of associating stored images with current images |
US20040077941A1 (en) * | 2002-10-21 | 2004-04-22 | Ge Medical Systems Global Technology Company, Llc | Method and system for image improvement with ECG gating and dose reduction in CT imaging |
US20040097805A1 (en) * | 2002-11-19 | 2004-05-20 | Laurent Verard | Navigation system for cardiac therapies |
US7729743B2 (en) * | 2003-01-07 | 2010-06-01 | Koninklijke Philips Electronics N.V. | Method and arrangement for tracking a medical instrument |
US20050031176A1 (en) * | 2003-08-08 | 2005-02-10 | Hertel Sarah R. | Method and apparatus of multi-modality image fusion |
US20050043614A1 (en) * | 2003-08-21 | 2005-02-24 | Huizenga Joel T. | Automated methods and systems for vascular plaque detection and analysis |
US20100049034A1 (en) * | 2003-09-04 | 2010-02-25 | Koninklijke Philips Electronics N.V. | Device and method for displaying ultrasound images of a vessel |
US20070038081A1 (en) * | 2003-09-04 | 2007-02-15 | Koninklijke Philips Electronics N.V. | Device and method for displaying ultrasound images of a vessel |
US20050054916A1 (en) * | 2003-09-05 | 2005-03-10 | Varian Medical Systems Technologies, Inc. | Systems and methods for gating medical procedures |
US20050096589A1 (en) * | 2003-10-20 | 2005-05-05 | Yehoshua Shachar | System and method for radar-assisted catheter guidance and control |
US20050090737A1 (en) * | 2003-10-22 | 2005-04-28 | Burrell Marc A. | Method, apparatus and product for acquiring cardiac images |
US20050228359A1 (en) * | 2004-04-07 | 2005-10-13 | Doyle Aiden J | Method and apparatus for treating acute stroke |
US7339585B2 (en) * | 2004-07-19 | 2008-03-04 | Pie Medical Imaging B.V. | Method and apparatus for visualization of biological structures with use of 3D position information from segmentation results |
US20090074284A1 (en) * | 2004-08-31 | 2009-03-19 | Carl Zeiss Microimaging Ais, Inc. | System and method for creating magnified images of a microscope slide |
US20060074285A1 (en) * | 2004-09-24 | 2006-04-06 | Paieon Inc. | Apparatus and method for fusion and in-operating-room presentation of volumetric data and 3-D angiographic data |
US20080021331A1 (en) * | 2004-09-29 | 2008-01-24 | Yeda Research And Development Co. Ltd. | Characterization of moving objects in a stationary background |
US7877132B2 (en) * | 2005-04-26 | 2011-01-25 | Koninklijke Philips Electronics N.V. | Medical viewing system and method for detecting and enhancing static structures in noisy images using motion of the image acquisition means |
US7889905B2 (en) * | 2005-05-23 | 2011-02-15 | The Penn State Research Foundation | Fast 3D-2D image registration method with application to continuously guided endoscopy |
US20130030295A1 (en) * | 2005-06-24 | 2013-01-31 | Volcano Corporation | Three Dimensional Co-Registration for Intravascular Diagnosis and Therapy |
US20070038061A1 (en) * | 2005-06-24 | 2007-02-15 | Volcano Corporation | Three dimensional co-registration for intravascular diagnosis and therapy |
US20070043292A1 (en) * | 2005-08-08 | 2007-02-22 | Siemens Aktiengesellschaft | Method for acquiring and evaluating vascular examination data |
US20070055128A1 (en) * | 2005-08-24 | 2007-03-08 | Glossop Neil D | System, method and devices for navigated flexible endoscopy |
US7343032B2 (en) * | 2005-09-01 | 2008-03-11 | Fujifilm Corporation | Method and apparatus for automatic and dynamic vessel detection |
US20070053558A1 (en) * | 2005-09-06 | 2007-03-08 | Pie Medical Imaging B.V. | Method, apparatus and computer program for contour detection of vessels using x-ray densitometry |
US20070060798A1 (en) * | 2005-09-15 | 2007-03-15 | Hagai Krupnik | System and method for presentation of data streams |
US20080015677A1 (en) * | 2006-06-09 | 2008-01-17 | Glossop Neil D | System for image-guided endovascular prosthesis and method for using same |
US20080008366A1 (en) * | 2006-06-20 | 2008-01-10 | Vladimir Desh | Simultaneous visualization, analysis and navigation of multi-modality medical imaging data |
US7916912B2 (en) * | 2006-09-14 | 2011-03-29 | Siemens Israel Ltd. | Efficient border extraction of image feature |
US20120004529A1 (en) * | 2007-03-08 | 2012-01-05 | Sync-Rx, Ltd. | Automatic display of previously-acquired endoluminal images |
US20120004537A1 (en) * | 2007-03-08 | 2012-01-05 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
US20100041949A1 (en) * | 2007-03-12 | 2010-02-18 | David Tolkowsky | Devices and methods for performing medical procedures in tree-like luminal structures |
US8364242B2 (en) * | 2007-05-17 | 2013-01-29 | General Electric Company | System and method of combining ultrasound image acquisition with fluoroscopic image acquisition |
US20090016587A1 (en) * | 2007-07-09 | 2009-01-15 | Siemens Corporate Research, Inc. | System and method for two-dimensional visualization of temporal phenomena and three dimensional vessel reconstruction |
US20110015520A1 (en) * | 2008-03-17 | 2011-01-20 | Koninklijke Philips Electronics N.V. | Perfusion imaging |
US20110033094A1 (en) * | 2008-04-17 | 2011-02-10 | Michael Zarkh | Method and apparatus for navigating a therapeutic device to a location |
US20100054573A1 (en) * | 2008-08-27 | 2010-03-04 | Raja Shekhara | Method and system for delineation of vasculature |
US20100067768A1 (en) * | 2008-09-18 | 2010-03-18 | Siemens Corporate Research, Inc. | Method and System for Physiological Image Registration and Fusion |
US20120069167A1 (en) * | 2009-05-18 | 2012-03-22 | Koninklijke Philips Electronics N.V. | Marker-free tracking registration and calibration for em-tracked endoscopic system |
US20110026786A1 (en) * | 2009-07-31 | 2011-02-03 | Siemens Corporation | Method and system for facilitating an image guided medical procedure |
US20110052030A1 (en) * | 2009-09-03 | 2011-03-03 | Herbert Bruder | Iterative ct image filter for noise reduction |
US20110071404A1 (en) * | 2009-09-23 | 2011-03-24 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US8396276B2 (en) * | 2009-10-26 | 2013-03-12 | Boston Scientific Scimed, Inc. | Systems and methods for performing an image-based gating procedure during an IVUS imaging procedure |
US20130053664A1 (en) * | 2010-01-29 | 2013-02-28 | Edwards Lifesciences Corporation | Elimination of the effects of irregular cardiac cycles in the determination of cardiovascular parameters |
US20120004533A1 (en) * | 2010-05-03 | 2012-01-05 | Slemens Corporation | Optimization of multiple candidates in medical device or feature tracking |
US20120059253A1 (en) * | 2010-06-29 | 2012-03-08 | Siemens Aktiengesellschaft | Method and System for Image Based Device Tracking for Co-registration of Angiography and Intravascular Ultrasound Images |
US20120014574A1 (en) * | 2010-07-13 | 2012-01-19 | Sigrid Ferschel | Method for Determining Properties of a Vessel in a Medical Image |
US20120029339A1 (en) * | 2010-07-29 | 2012-02-02 | Sync-Rx, Ltd. | Accounting for forward motion during pullback of an endoluminal imaging probe |
US20120059220A1 (en) * | 2010-08-20 | 2012-03-08 | Troy Holsing | Apparatus and method for four dimensional soft tissue navigation in endoscopic applications |
US20120051606A1 (en) * | 2010-08-24 | 2012-03-01 | Siemens Information Systems Ltd. | Automated System for Anatomical Vessel Characteristic Determination |
US20120065507A1 (en) * | 2010-09-09 | 2012-03-15 | Siemens Medical Solutions Usa, Inc. | Reduction of motion artifacts in ultrasound imaging with a flexible ultrasound transducer |
US20120072190A1 (en) * | 2010-09-16 | 2012-03-22 | Siemens Corporation | Method and System for Non-Invasive Assessment of Coronary Artery Disease |
US20130004044A1 (en) * | 2011-06-29 | 2013-01-03 | The Regents Of The University Of Michigan | Tissue Phasic Classification Mapping System and Method |
US20130046167A1 (en) * | 2011-08-17 | 2013-02-21 | Volcano Corporation | Systems and Methods for Identifying Vascular Borders |
Cited By (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10856769B2 (en) | 1999-05-18 | 2020-12-08 | St. Jude Medical International Holding S.àr.l. | Method and system for superimposing virtual anatomical landmarks on an image |
US20090182224A1 (en) * | 1999-05-18 | 2009-07-16 | Mediguide Ltd. | Method and apparatus for invasive device tracking using organ timing signal generated from MPS sensors |
US9956049B2 (en) | 1999-05-18 | 2018-05-01 | Mediguide Ltd. | Method and apparatus for invasive device tracking using organ timing signal generated from MPS sensors |
US9833167B2 (en) | 1999-05-18 | 2017-12-05 | Mediguide Ltd. | Method and system for superimposing virtual anatomical landmarks on an image |
US9572519B2 (en) | 1999-05-18 | 2017-02-21 | Mediguide Ltd. | Method and apparatus for invasive device tracking using organ timing signal generated from MPS sensors |
US20110054308A1 (en) * | 1999-05-18 | 2011-03-03 | Amit Cohen | Method and system for superimposing virtual anatomical landmarks on an image |
US10251712B2 (en) | 1999-05-18 | 2019-04-09 | Mediguide Ltd. | Method and apparatus for invasive device tracking using organ timing signal generated from MPS sensors |
US10363017B2 (en) * | 2001-09-07 | 2019-07-30 | St. Jude Medical International Holding S.À R.L. | System and method for delivering a stent to a selected position within a lumen |
US20130166011A1 (en) * | 2001-09-07 | 2013-06-27 | Gera Strommer | System and method for delivering a stent to a selected position within a lumen |
US20060084962A1 (en) * | 2004-06-02 | 2006-04-20 | Cryovascular Systems, Inc. | Controllable pressure cryogenic balloon treatment system and method |
US8177779B2 (en) * | 2004-06-02 | 2012-05-15 | Boston Scientific Scimed, Inc. | Controllable pressure cryogenic balloon treatment system and method |
US20060258933A1 (en) * | 2005-05-10 | 2006-11-16 | Advanced Clinical Solutions, Inc. | Method of defining a biological target for treatment |
US7831293B2 (en) * | 2005-05-10 | 2010-11-09 | Advanced Clinical Solutions, Inc. | Method of defining a biological target for treatment |
US10201388B2 (en) | 2005-12-06 | 2019-02-12 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Graphical user interface for real-time RF lesion depth display |
US11517372B2 (en) | 2005-12-06 | 2022-12-06 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing lesions in tissue |
US9283025B2 (en) | 2005-12-06 | 2016-03-15 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling for tissue ablation |
US9283026B2 (en) | 2005-12-06 | 2016-03-15 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling for tissue ablation |
US9271782B2 (en) | 2005-12-06 | 2016-03-01 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling of tissue ablation |
US9254163B2 (en) | 2005-12-06 | 2016-02-09 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling for tissue ablation |
US9173586B2 (en) | 2005-12-06 | 2015-11-03 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing coupling between an electrode and tissue |
US9492226B2 (en) | 2005-12-06 | 2016-11-15 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Graphical user interface for real-time RF lesion depth display |
US10362959B2 (en) | 2005-12-06 | 2019-07-30 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing the proximity of an electrode to tissue in a body |
US9610119B2 (en) | 2005-12-06 | 2017-04-04 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing the formation of a lesion in tissue |
US10182860B2 (en) | 2005-12-06 | 2019-01-22 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling for tissue ablation |
US20130103064A1 (en) * | 2006-05-12 | 2013-04-25 | Vytronus, Inc. | Integrated ablation and mapping system |
US9014453B2 (en) | 2007-03-08 | 2015-04-21 | Sync-Rx, Ltd. | Automatic angiogram detection |
US8290228B2 (en) | 2007-03-08 | 2012-10-16 | Sync-Rx, Ltd. | Location-sensitive cursor control and its use for vessel analysis |
US9888969B2 (en) | 2007-03-08 | 2018-02-13 | Sync-Rx Ltd. | Automatic quantitative vessel analysis |
US20100160773A1 (en) * | 2007-03-08 | 2010-06-24 | Sync-Rx, Ltd. | Automatic quantitative vessel analysis at the location of an automatically-detected tool |
US8781193B2 (en) * | 2007-03-08 | 2014-07-15 | Sync-Rx, Ltd. | Automatic quantitative vessel analysis |
US9968256B2 (en) | 2007-03-08 | 2018-05-15 | Sync-Rx Ltd. | Automatic identification of a tool |
US20100171819A1 (en) * | 2007-03-08 | 2010-07-08 | Sync-Rx, Ltd. | Automatic reduction of interfering elements from an image stream of a moving organ |
US11064964B2 (en) | 2007-03-08 | 2021-07-20 | Sync-Rx, Ltd | Determining a characteristic of a lumen by measuring velocity of a contrast agent |
US9008754B2 (en) | 2007-03-08 | 2015-04-14 | Sync-Rx, Ltd. | Automatic correction and utilization of a vascular roadmap comprising a tool |
US9008367B2 (en) | 2007-03-08 | 2015-04-14 | Sync-Rx, Ltd. | Apparatus and methods for reducing visibility of a periphery of an image stream |
US8693756B2 (en) * | 2007-03-08 | 2014-04-08 | Sync-Rx, Ltd. | Automatic reduction of interfering elements from an image stream of a moving organ |
US9855384B2 (en) | 2007-03-08 | 2018-01-02 | Sync-Rx, Ltd. | Automatic enhancement of an image stream of a moving organ and displaying as a movie |
US10716528B2 (en) | 2007-03-08 | 2020-07-21 | Sync-Rx, Ltd. | Automatic display of previously-acquired endoluminal images |
US8670603B2 (en) * | 2007-03-08 | 2014-03-11 | Sync-Rx, Ltd. | Apparatus and methods for masking a portion of a moving image stream |
US9717415B2 (en) * | 2007-03-08 | 2017-08-01 | Sync-Rx, Ltd. | Automatic quantitative vessel analysis at the location of an automatically-detected tool |
US10499814B2 (en) | 2007-03-08 | 2019-12-10 | Sync-Rx, Ltd. | Automatic generation and utilization of a vascular roadmap |
US20130329977A1 (en) * | 2007-03-08 | 2013-12-12 | Sync-Rx, Ltd. | Automatic reduction of interfering elements from an image stream of a moving organ |
US8542900B2 (en) * | 2007-03-08 | 2013-09-24 | Sync-Rx Ltd. | Automatic reduction of interfering elements from an image stream of a moving organ |
US9629571B2 (en) | 2007-03-08 | 2017-04-25 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
WO2010058398A3 (en) * | 2007-03-08 | 2010-07-22 | Sync-Rx, Ltd. | Image processing and tool actuation for medical procedures |
US9375164B2 (en) | 2007-03-08 | 2016-06-28 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
US10226178B2 (en) | 2007-03-08 | 2019-03-12 | Sync-Rx Ltd. | Automatic reduction of visibility of portions of an image |
US8463007B2 (en) | 2007-03-08 | 2013-06-11 | Sync-Rx, Ltd. | Automatic generation of a vascular skeleton |
US10307061B2 (en) | 2007-03-08 | 2019-06-04 | Sync-Rx, Ltd. | Automatic tracking of a tool upon a vascular roadmap |
US9216065B2 (en) | 2007-03-08 | 2015-12-22 | Sync-Rx, Ltd. | Forming and displaying a composite image |
US8700130B2 (en) | 2007-03-08 | 2014-04-15 | Sync-Rx, Ltd. | Stepwise advancement of a medical tool |
US20120230565A1 (en) * | 2007-03-08 | 2012-09-13 | Sync-Rx, Ltd. | Automatic quantitative vessel analysis |
US11179038B2 (en) | 2007-03-08 | 2021-11-23 | Sync-Rx, Ltd | Automatic stabilization of a frames of image stream of a moving organ having intracardiac or intravascular tool in the organ that is displayed in movie format |
US11197651B2 (en) | 2007-03-08 | 2021-12-14 | Sync-Rx, Ltd. | Identification and presentation of device-to-vessel relative motion |
US9305334B2 (en) | 2007-03-08 | 2016-04-05 | Sync-Rx, Ltd. | Luminal background cleaning |
US9308052B2 (en) | 2007-03-08 | 2016-04-12 | Sync-Rx, Ltd. | Pre-deployment positioning of an implantable device within a moving organ |
US10555685B2 (en) | 2007-12-28 | 2020-02-11 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and apparatus for determining tissue morphology based on phase angle |
US20110144690A1 (en) * | 2008-05-14 | 2011-06-16 | Onset Medical Corporation | Expandable transapical sheath and method of use |
US9440054B2 (en) | 2008-05-14 | 2016-09-13 | Onset Medical Corporation | Expandable transapical sheath and method of use |
US8728153B2 (en) | 2008-05-14 | 2014-05-20 | Onset Medical Corporation | Expandable transapical sheath and method of use |
US10362962B2 (en) | 2008-11-18 | 2019-07-30 | Synx-Rx, Ltd. | Accounting for skipped imaging locations during movement of an endoluminal imaging probe |
US9144394B2 (en) | 2008-11-18 | 2015-09-29 | Sync-Rx, Ltd. | Apparatus and methods for determining a plurality of local calibration factors for an image |
US11883149B2 (en) | 2008-11-18 | 2024-01-30 | Sync-Rx Ltd. | Apparatus and methods for mapping a sequence of images to a roadmap image |
US11064903B2 (en) | 2008-11-18 | 2021-07-20 | Sync-Rx, Ltd | Apparatus and methods for mapping a sequence of images to a roadmap image |
US8855744B2 (en) | 2008-11-18 | 2014-10-07 | Sync-Rx, Ltd. | Displaying a device within an endoluminal image stack |
US9974509B2 (en) | 2008-11-18 | 2018-05-22 | Sync-Rx Ltd. | Image super enhancement |
US9101286B2 (en) | 2008-11-18 | 2015-08-11 | Sync-Rx, Ltd. | Apparatus and methods for determining a dimension of a portion of a stack of endoluminal data points |
US9095313B2 (en) | 2008-11-18 | 2015-08-04 | Sync-Rx, Ltd. | Accounting for non-uniform longitudinal motion during movement of an endoluminal imaging probe |
US8900150B2 (en) | 2008-12-30 | 2014-12-02 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Intracardiac imaging system utilizing a multipurpose catheter |
US20100168557A1 (en) * | 2008-12-30 | 2010-07-01 | Deno D Curtis | Multi-electrode ablation sensing catheter and system |
US10206652B2 (en) | 2008-12-30 | 2019-02-19 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Intracardiac imaging system utilizing a multipurpose catheter |
US9610118B2 (en) | 2008-12-31 | 2017-04-04 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and apparatus for the cancellation of motion artifacts in medical interventional navigation |
DE102009009158A1 (en) * | 2009-02-16 | 2010-09-02 | Siemens Aktiengesellschaft | Medical instrument e.g. aortic valve, localization method, involves finding image of image sequence as reference image, and detecting position of instrument in reference image, where instrument position is assigned to position of landmarks |
DE102009009158B4 (en) * | 2009-02-16 | 2010-11-04 | Siemens Aktiengesellschaft | Localization of a medical instrument in a pre-invasively acquired tomographic image dataset |
US9034294B1 (en) | 2009-04-24 | 2015-05-19 | Simbol, Inc. | Preparation of lithium carbonate from lithium chloride containing brines |
US9034295B2 (en) | 2009-04-24 | 2015-05-19 | Simbol, Inc. | Preparation of lithium carbonate from lithium chloride containing brines |
US10829676B2 (en) | 2009-04-24 | 2020-11-10 | Terralithium Llc | Treated geothermal brine compositions with reduced concentration of silica, iron and lithium |
US10190030B2 (en) | 2009-04-24 | 2019-01-29 | Alger Alternative Energy, Llc | Treated geothermal brine compositions with reduced concentrations of silica, iron and lithium |
US11649170B2 (en) | 2009-04-24 | 2023-05-16 | Terralithium Llc | Preparation of lithium carbonate from lithium chloride containing brines |
US9834449B2 (en) | 2009-04-24 | 2017-12-05 | Alger Alternative Energy, Llc | Preparation of lithium carbonate from lithium chloride containing brines |
US10773970B2 (en) | 2009-04-24 | 2020-09-15 | Terralithium Llc | Preparation of lithium carbonate from lithium chloride containing brines |
US11466191B2 (en) | 2009-04-24 | 2022-10-11 | Terralithium Llc | Treated geothermal brine compositions with reduced concentration of silica, iron and lithium |
US20120029504A1 (en) * | 2009-05-13 | 2012-02-02 | Afonso Valtino X | System and method for presenting information representative of lesion formation in tissue during an ablation procedure |
US10675086B2 (en) | 2009-05-13 | 2020-06-09 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for presenting information representative of lesion formation in tissue during an ablation procedure |
US9204927B2 (en) * | 2009-05-13 | 2015-12-08 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for presenting information representative of lesion formation in tissue during an ablation procedure |
US11828272B2 (en) | 2009-06-24 | 2023-11-28 | Terralithium Llc | Process for producing geothermal power, selective removal of silica and iron from brines, and improved injectivity of treated brines |
US9051827B1 (en) | 2009-09-02 | 2015-06-09 | Simbol Mining Corporation | Selective removal of silica from silica containing brines |
US20120188352A1 (en) * | 2009-09-07 | 2012-07-26 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Concept of superimposing an intraoperative live image of an operating field with a preoperative image of the operating field |
US8731642B2 (en) * | 2009-11-08 | 2014-05-20 | Paieon Inc. | Apparatus and method for locating a device tip within a volume |
US20110112398A1 (en) * | 2009-11-08 | 2011-05-12 | Paieon Inc. | Apparatus and method for locating a device tip within a volume |
US9012357B2 (en) | 2009-12-18 | 2015-04-21 | Simbol, Inc. | Lithium extraction composition and method of preparation thereof |
US9074265B2 (en) | 2010-02-17 | 2015-07-07 | Simbol, Inc. | Processes for preparing highly pure lithium carbonate and other highly pure lithium containing compounds |
US8948476B2 (en) * | 2010-12-20 | 2015-02-03 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Determination of cardiac geometry responsive to doppler based imaging of blood flow characteristics |
US20120155723A1 (en) * | 2010-12-20 | 2012-06-21 | Deno D Curtis | Determination of cardiac geometry responsive to doppler based imaging of blood flow characteristics |
US10748289B2 (en) | 2012-06-26 | 2020-08-18 | Sync-Rx, Ltd | Coregistration of endoluminal data points with values of a luminal-flow-related index |
US10984531B2 (en) | 2012-06-26 | 2021-04-20 | Sync-Rx, Ltd. | Determining a luminal-flow-related index using blood velocity determination |
EP2921123A4 (en) * | 2012-11-13 | 2016-06-15 | Olympus Corp | Medical device |
CN104602627A (en) * | 2012-11-13 | 2015-05-06 | 奥林巴斯株式会社 | Medical device |
US9801659B2 (en) | 2012-11-13 | 2017-10-31 | Olympus Corporation | Medical device |
US10076301B2 (en) | 2012-12-31 | 2018-09-18 | Volcano Corporation | Devices, systems, and methods for assessment of vessels |
US9351698B2 (en) | 2013-03-12 | 2016-05-31 | Lightlab Imaging, Inc. | Vascular data processing and image registration systems, methods, and apparatuses |
US10687777B2 (en) | 2013-03-12 | 2020-06-23 | Lightlab Imaging, Inc. | Vascular data processing and image registration systems, methods, and apparatuses |
US9907527B2 (en) | 2013-03-12 | 2018-03-06 | Lightlab Imaging, Inc. | Vascular data processing and image registration systems, methods, and apparatuses |
US9613289B2 (en) | 2013-12-02 | 2017-04-04 | Toshiba Medical Systems Corporation | X-ray diagnosis apparatus and image processing apparatus |
US9539090B2 (en) | 2014-01-16 | 2017-01-10 | Cook Medical Technologies Llc | Transaortic valve access device |
EP2896425A1 (en) * | 2014-01-16 | 2015-07-22 | Cook Medical Technologies LLC | Transaortic valve access device |
WO2015155770A1 (en) | 2014-04-10 | 2015-10-15 | Sync-Rx, Ltd. | Image analysis in the presence of a medical device |
US11744544B2 (en) | 2014-05-06 | 2023-09-05 | Philips Image Guided Therapy Corporation | Devices, systems, and methods for vessel assessment |
US10152788B2 (en) | 2014-05-14 | 2018-12-11 | Sync-Rx Ltd. | Object identification |
US11676272B2 (en) | 2014-05-14 | 2023-06-13 | Sync-Rx Ltd. | Object identification |
EP3200155A1 (en) | 2014-05-14 | 2017-08-02 | Sync-RX, Ltd. | Object identification |
US10916009B2 (en) | 2014-05-14 | 2021-02-09 | Sync-Rx Ltd. | Object identification |
US10531841B2 (en) | 2014-07-15 | 2020-01-14 | Volcano Corporation | Devices, systems, and methods and associated display screens for assessment of vessels with multiple sensing components |
US10499813B2 (en) | 2014-09-12 | 2019-12-10 | Lightlab Imaging, Inc. | Methods, systems and apparatus for temporal calibration of an intravascular imaging system |
US10105107B2 (en) | 2015-01-08 | 2018-10-23 | St. Jude Medical International Holding S.À R.L. | Medical system having combined and synergized data output from multiple independent inputs |
US10713786B2 (en) | 2015-05-17 | 2020-07-14 | Lightlab Imaging, Inc. | Detection of metal stent struts |
US10109058B2 (en) | 2015-05-17 | 2018-10-23 | Lightlab Imaging, Inc. | Intravascular imaging system interfaces and stent detection methods |
US10222956B2 (en) | 2015-05-17 | 2019-03-05 | Lightlab Imaging, Inc. | Intravascular imaging user interface systems and methods |
US10902599B2 (en) | 2015-05-17 | 2021-01-26 | Lightlab Imaging, Inc. | Stent detection methods and imaging system interfaces |
US11532087B2 (en) | 2015-05-17 | 2022-12-20 | Lightlab Imaging, Inc. | Stent detection methods and imaging system interfaces |
US9996921B2 (en) | 2015-05-17 | 2018-06-12 | LIGHTLAB IMAGING, lNC. | Detection of metal stent struts |
US11367186B2 (en) | 2015-05-17 | 2022-06-21 | Lightlab Imaging, Inc. | Detection of metal stent struts |
US10646198B2 (en) | 2015-05-17 | 2020-05-12 | Lightlab Imaging, Inc. | Intravascular imaging and guide catheter detection methods and systems |
US11768593B2 (en) | 2015-07-25 | 2023-09-26 | Lightlab Imaging, Inc. | Intravascular data visualization and interface systems and methods |
US11287961B2 (en) | 2015-07-25 | 2022-03-29 | Lightlab Imaging, Inc. | Intravascular data visualization and interface systems and methods |
US11783607B2 (en) | 2015-09-10 | 2023-10-10 | Sync-Rx Ltd | Automatic image feature removal |
US10929702B2 (en) | 2015-09-10 | 2021-02-23 | Sync-Rx, Ltd | Automatic image feature removal |
US11020078B2 (en) | 2015-11-18 | 2021-06-01 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US10342502B2 (en) | 2015-11-18 | 2019-07-09 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US10172582B2 (en) | 2015-11-18 | 2019-01-08 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US10327726B2 (en) | 2015-11-18 | 2019-06-25 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US11633167B2 (en) | 2015-11-18 | 2023-04-25 | Lightlab Imaging, Inc. | X-ray image feature detection and registration systems and methods |
US11850089B2 (en) | 2015-11-19 | 2023-12-26 | Lightlab Imaging, Inc. | Intravascular imaging and guide catheter detection methods and systems |
US10453190B2 (en) | 2015-11-23 | 2019-10-22 | Lightlab Imaging, Inc. | Detection of and validation of shadows in intravascular images |
US10593037B2 (en) | 2016-04-14 | 2020-03-17 | Lightlab Imaging, Inc. | Method, apparatus, and system to identify branches of a blood vessel |
US11475560B2 (en) | 2016-04-14 | 2022-10-18 | Lightlab Imaging, Inc. | Method, apparatus, and system to identify branches of a blood vessel |
CN108135652B (en) * | 2016-04-26 | 2021-01-12 | 奥林巴斯株式会社 | Energy treatment instrument, treatment system, and control device |
CN108135652A (en) * | 2016-04-26 | 2018-06-08 | 奥林巴斯株式会社 | Energy treatment apparatus, disposal system and control device |
US10631754B2 (en) | 2016-05-16 | 2020-04-28 | Lightlab Imaging, Inc. | Intravascular absorbable stent detection and diagnostic methods and systems |
WO2017221159A1 (en) | 2016-06-22 | 2017-12-28 | Sync-Rx, Ltd. | Updating an indication of a lumen location |
WO2017220703A1 (en) | 2016-06-22 | 2017-12-28 | Sync-Rx, Ltd | Estimating the endoluminal path of an endoluminal device along a lumen |
US11147628B2 (en) | 2016-06-22 | 2021-10-19 | Sync-Rx, Ltd | Updating an indication of a lumen location |
US11877811B2 (en) | 2016-06-22 | 2024-01-23 | Sync-Rx Ltd. | Updating an indication of a lumen location |
US11202679B2 (en) | 2016-06-22 | 2021-12-21 | Sync-Rx Ltd. | Estimating the endoluminal path of an endoluminal device along a lumen |
WO2018067252A1 (en) * | 2016-10-06 | 2018-04-12 | Medtronic Vascular Inc. | System and method for crossing a native heart valve with a guidewire |
US10604414B2 (en) | 2017-06-15 | 2020-03-31 | Energysource Minerals Llc | System and process for recovery of lithium from a geothermal brine |
US20200294213A1 (en) * | 2019-03-12 | 2020-09-17 | GE Precision Healthcare LLC | System and method for simulating bilateral injection of contrast agent into a patient |
US11037280B2 (en) * | 2019-03-12 | 2021-06-15 | GE Precision Healthcare LLC | System and method for simulating bilateral injection of contrast agent into a patient |
Also Published As
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JP5639764B2 (en) | 2014-12-10 |
EP2129284A2 (en) | 2009-12-09 |
US20140114308A1 (en) | 2014-04-24 |
JP2015013170A (en) | 2015-01-22 |
US20080221439A1 (en) | 2008-09-11 |
WO2008107905A3 (en) | 2010-02-18 |
US20150283319A1 (en) | 2015-10-08 |
WO2008107905A2 (en) | 2008-09-12 |
EP2129284A4 (en) | 2012-11-28 |
US20140114333A1 (en) | 2014-04-24 |
US9855384B2 (en) | 2018-01-02 |
JP2010521198A (en) | 2010-06-24 |
US20100172556A1 (en) | 2010-07-08 |
US20080221442A1 (en) | 2008-09-11 |
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