US20090287304A1 - Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve - Google Patents
Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve Download PDFInfo
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- US20090287304A1 US20090287304A1 US12/120,195 US12019508A US2009287304A1 US 20090287304 A1 US20090287304 A1 US 20090287304A1 US 12019508 A US12019508 A US 12019508A US 2009287304 A1 US2009287304 A1 US 2009287304A1
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- anchors
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- anchor
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- orifice
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0485—Devices or means, e.g. loops, for capturing the suture thread and threading it through an opening of a suturing instrument or needle eyelet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
- A61B2017/003—Steerable
- A61B2017/00318—Steering mechanisms
- A61B2017/00331—Steering mechanisms with preformed bends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0409—Instruments for applying suture anchors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0427—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body
- A61B2017/0437—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body the barbs being resilient or spring-like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/044—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors with a threaded shaft, e.g. screws
- A61B2017/0441—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors with a threaded shaft, e.g. screws the shaft being a rigid coil or spiral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0464—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors for soft tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B2017/0496—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials for tensioning sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
Definitions
- Cardiac surgery was initially undertaken only by performing a sternotomy, a type of incision in the center of the chest, which separates the sternum (chest bone) to allow access to the heart.
- a percutaneous technique which is a medical procedure where access to inner organs or other tissue is gained via a catheter.
- At least one embodiment may be summarized as a method of constricting tissue or a bodily orifice or cavity, the method comprising delivering a plurality of anchors to the tissue or bodily orifice or cavity intravascularly; implanting the plurality of anchors; connecting the plurality of anchors by at least one joining member; and contracting at least one joining member.
- FIG. 11 is a diagram of an expanded anchor guiding frame according to one illustrated embodiment.
- FIG. 18 is a diagram of a mechanism according to one illustrated embodiment for restricting a tissue anchor from release until said anchor is fully embedded in tissue
- the guide wires 112 shown preferably have hinges 113 and may be connected with small loops 109 .
- the hinges 113 and loops 109 enable the guiding frame to fold up to fit inside a catheter and to expand to extend across an orifice. Both the hinges 113 and loops 109 may be replaced by other mechanisms that enable bending.
- the medical device 100 typically has an articulating mechanism 106 that enables correctly orienting the anchor guiding mechanism during deployment of tissue anchors 107 .
- the articulating mechanism 106 is preferably able to bend in any direction.
- the control knobs 103 and 104 may be used to control the bending of the articulating mechanism 106 using cables that are carried in the long flexible tube 105 .
- FIG. 4 shows an example of a tissue anchor according to one illustrated embodiment.
- Tissue anchor 403 is shown in a compressed configuration and tissue anchor 406 is shown in an expanded configuration.
- the tissue anchors 403 , 406 comprise multiple barbs 408 .
- the multiple barbs 408 may be compressed into constricting tube 404 as shown for tissue anchor 403 . Compression of barbs 408 into constricting tube 404 enables the anchor to move more readily through a catheter and also to be inserted more readily into tissue.
- Helical tissue anchor 706 is shown fully deployed into tissue 708 and disconnected from to latch mechanism 709 .
- Latch mechanism 709 may become disconnected from anchor 706 by retracting push tube 703 or releasing latch mechanism 709 with the addition of another cable to trigger a release mechanism.
- the distal links such as link 1113 and link 1114
- the proximal links such as link 1115 and 1116 .
- One embodiment to enable such an attribute is to insert springs, as indicated by 1108 and 1102 , with varying spring constant k between the links.
- the distal links should be forced apart by springs with a higher spring constant than the springs between the proximal links.
- Another embodiment for enabling unequal separation of links is to control the shape of the guide wires 1104 that are routed through the articulating mechanism 1107 .
- the guide wires should have a preformed bend with a decreasing radius of curvature in the area from proximal link 1115 to distal link 1114 .
- the element capable of changing lengths may be made of a spring under tension encapsulated in material that melts under low heat and solidifies at body temperature—such as a thermoplastic polymer.
- Current induced in a loop by an external magnetic field may be channeled through the spring. The current may heat the spring which will cause the polymer to soften and the spring length to contract. The contraction of the spring can be used to reduce the separation of the tissue anchors.
- Embodiments of such actuators are described in U.S. Ser. No. 11/905,771.
- Taper lock 1509 may have teeth 1515 to grip cable end 1503 .
- Taper lock 1509 may have a longitudinal slot to enable compression of taper lock 1509 and constriction around cable end 1503 .
- Spring 1508 may force taper lock 1509 into a conical hole 1514 , causing it to tighten around cable end 1503 .
- cable end 1503 may be severed using cable cutting tube 1501 .
- Cable cutting tube 1501 comprises a sharpened end 1516 .
- Cable cutting tube 1501 is shown in a retracted position. The cable cutting tube may slide inside of fastener positioning tube 1506 .
- Cable cutting tube 1512 is shown in the cable cutting position. Cable cutting tube 1512 may sever cable end 1513 by forcing cable end 1513 against the end of slot 1516 .
- the cable end may be severed in other ways, including using a hot tip to melt through the cable.
- Catheter 1604 is shown with cables 1601 held within longitudinal groove 1603 on the inner surface of the tube wall by tube 1602 .
- the longitudinal groove 1603 has a cross sectional shape that enables tube 1602 to be held captive.
- FIG. 16 shows a circular groove, but other shapes may be used.
- Tube 1602 carries cables 1601 .
- Tube 1602 could also carry wires or tubes.
- cables 1605 are free to move into the central area of the tube.
- Tube 1602 can be reinserted over cables 1605 to again constrain them in groove 1603 .
- FIG. 16 shows catheter 1604 and catheter 1607 with only one groove 1603 , it is possible to have many such grooves in a catheter and to secure a plurality of wires and tubes in said grooves.
- One of the reasons for securing cables or wires in grooves, or side slots, is to eliminate tangling of cables or wires during medical procedures.
- Tissue anchor 1703 may be released from constricting tube 1706 by retracting push tube 1701 and constricting tube 1706 relative to release rod 1704 . As the distal end of constricting tube 1706 clears hole 1707 , release rod tip 1708 will pop out of hole 1707 and tissue anchor 1703 will no longer be held captive.
- Tissue anchor 1808 is shown fully deployed into tissue 1812 . As tissue anchor 1808 was deployed into tissue 1812 , the surface of tissue 1812 causes lever 1811 to bend. When lever 1811 is bent, latch 1810 clears notch 1813 . Once latch 1810 clears notch 1813 , tissue anchor 1808 may be released from constricting tube 1809
Abstract
Description
- 1. Field
- This disclosure is generally related to percutaneous or minimally invasive surgery, and more particularly to percutaneously deployed medical devices suitable for constricting tissue or a bodily orifice such as a mitral valve
- 2. Description of the Related Art
- Cardiac surgery was initially undertaken only by performing a sternotomy, a type of incision in the center of the chest, which separates the sternum (chest bone) to allow access to the heart. In the previous several decades, more and more cardiac operations are performed using a percutaneous technique, which is a medical procedure where access to inner organs or other tissue is gained via a catheter.
- Percutaneous surgeries benefit patients by reducing surgery risk, complications, and recovery time. However, the use of percutaneous technologies also raises some particular challenges. Medical devices used in percutaneous surgery need to be deployed via narrow tubes called catheter sheaths, which significantly increase the complexity of the device structure. As well, doctors do not have direct visual contact with the medical tools used once they are placed within the body, and positioning the tools correctly and operating the tools successfully can often be very challenging.
- One example of where percutaneous medical techniques are starting to be used is in the treatment of a heart disorder called mitral regurgitation. Mitral regurgitation is a condition in which blood flows backward from the left ventricle into the left atrium. The mitral apparatus is made up of four major structural components and includes the annulus, the two leaflets, the chordae and the papillary muscles. Improper function of any one of these structures or in combination can lead to mitral regurgitation. Annular dilation is a major component in the pathology of mitral regurgitation regardless of causes and is manifested in mitral regurgitation related to dilated cardiomyopathy and chronic mitral regurgitation due to ischemia.
- The mitral valve is intended to prevent the undesired flow of blood from the left ventricle into the left atrium when the left ventricle contracts. In a normal mitral valve, the geometry of the mitral valve ensures the cusps overlay each other to preclude the regurgitation of blood during left ventricular contraction and thereby prevent elevation of pulmonary vascular pressures and resultant symptoms of shortness of breath. Studies of the natural history of mitral regurgitation have found that totally asymptomatic patients with severe mitral insufficiency usually progress to severe disability within 5 years.
- At present treatment consists of either mitral valve replacement or repair. Both methods require open heart surgery. Replacement can be performed with either mechanical or biological valves and is particularly suitable when one of the mitral cusps has been severely damaged or deformed. The mechanical valve carries the risk of thromboembolism and requires anticoagulation with all of its potential hazards, whereas the biological prosthesis suffers from limited durability. Another hazard with replacement is the risk of endocarditis. These risks and other valve related complications are greatly diminished with valve repair. Mitral valve repair is theoretically possible if the mitral valve leaflets are structurally normal but fail to appropriately coapt because of annular dilatation and/or papillary muscle dysfunction. Various surgical procedures have been developed to improve coaptation of the leaflet and to correct the deformation of the mitral valve annulus and retain the intact natural heart valve function. These procedures generally involve reducing the circumference of the posterior mitral leaflet annulus (lateral annulus) where most of the dilatation occurs. The annulus of the anterior leaflet (septal annulus) does not generally dilate because it is anchored to the fibrous skeleton at the base of the heart. Such techniques, known as mitral annuloplasty, typically suture a prosthesis around the base of the valve leaflets shortening the lateral annulus to reshape the mitral valve annulus and minimize further dilation. Different types of mitral annuloplasty prostheses have been developed for use in such surgery. In general, such prostheses are annular or partially annular shaped and may be formed from rigid or flexible material.
- Mitral valve surgery requires an extremely invasive approach that includes a chest wall incision, cardiopulmonary bypass, cardiac and pulmonary arrest, and an incision on the heart itself to gain access to the mitral valve. Such a procedure is expensive, requires considerable time, and is associated with high morbidity and mortality. Due to the risks associated with this procedure, many of the sickest patients are denied the potential benefits of surgical correction of mitral regurgitation. In addition, patients with moderate, symptomatic mitral regurgitation are denied early intervention and undergo surgical correction only after the development of cardiac dysfunction. Furthermore, the effectiveness of such procedures is difficult to assess during the procedure and may not be known until a much later time. Hence, the ability to make adjustments to or changes in the prosthesis function to obtain optimum effectiveness is extremely limited. Correction at a later date would require another open heart procedure.
- In an attempt to treat mitral regurgitation without the need for cardiopulmonary bypass and without opening the chest, percutaneous approaches have been devised to repair the valve or place a correcting apparatus for correcting the annulus relaxation. Such approaches make use of devices which can be generally grouped into two types:
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- devices deforming (mainly shortening) the coronary sinus
- devices pulling together two anchor points in order to affect the mitral valve, one of the anchor points can be the coronary sinus (typically using a wire that is pulled and secured).
- Neither approach emulates the current “gold standard” in mitral valve repair—annuloplasty using a ring the completely encircles the mitral valve. Both approaches suffer from several problems as a result of attempting to reshape the mitral annulus using an alternative method. Devices that deform the coronary sinus, while suitable for percutaneous procedures, are not effective in controlling the leakage of the mitral valve as the forces are not applied from the correct opposite sides of the valve, which are the lateral annulus and the septal annulus. The prior art devices of the second type are not easily adapted to a percutaneous procedure. In order to achieve shortening in the direction connecting the lateral annulus to the septal annulus the anchor points have to be located along this line, so pulling them together will affect the desired direction of shortening. Pulling applied along a different direction will distort the mitral valve but will not achieve the optimal approximation of the two leaflets.
- Thus, there is a need for methods and apparatus that enable the ability to create a full ring mitral annuloplasty via a percutaneous or intravascular procedure.
- The present design of a medical device with enhanced capabilities for percutaneous deployment and annulus cinching employs a superior method for constricting tissue or a bodily orifice, such as the mitral valve, tricuspid valve, or aortic valve. The device may employ methods that enable a complete ring to be anchored to tissue and may enable reduction of the circumference of said ring during installation or at a later time. Reference throughout this specification is made to cardiac surgery, but the invention may also be used in gastric surgery, bowel surgery, or other surgeries in which tissue may be drawn together. The invention may also be used to draw or hold tissue not part of an orifice or annulus together. The invention may be used in minimally invasive surgery as well as intravascular or percutaneous surgery. Other advantages will become apparent from the teaching herein to those of skill in the art.
- At least one embodiment may be summarized as a method of constricting tissue or a bodily orifice or cavity, the method comprising delivering a plurality of anchors to the tissue or bodily orifice or cavity intravascularly; implanting the plurality of anchors; connecting the plurality of anchors by at least one joining member; and contracting at least one joining member.
- The method may further include constricting a bodily orifice that is a mitral valve. The method may further include a flexible cable as the joining member. The anchors may comprise a helical portion or multiple barbs. The method may further include guiding the plurality of anchors to implant sites by means of at least one guide rail. The plurality of anchors may be released proximate to a change in curvature of the guide rail. Guide rails may be connected at distal tips.
- At least one embodiment may be summarized as a medical system for constricting an orifice including a device positionable in at least a portion of a bodily organ; a plurality of guide rails; a plurality of anchors releasably guided by said guide rails; at least one structure used to locate said guide rails; means of connecting said anchors and a means of shortening or bending said connecting means.
- The system may be deployed intravascularly. The medical system may be positionable in a left atrium of a heart. The system may further include a plurality of anchors that are released proximate to a change in curvature of said guide rails. The plurality of anchors may be held captive within a cap prior to deployment. The plurality of anchors may be restricted from release from guide rails or other restraining member until anchors are implanted into tissue. The system may further include a means of connecting anchors by a member that is shortened by application of an external magnetic field. The medical system may be foldable into a catheter.
- At least one embodiment may be summarized as a medical system for attaching a flexible member to tissue including a flexible member attached to tissue by a plurality of anchors; said plurality of anchors guided by a plurality of rails; said anchors releasable proximate to a change in curvature of said rails; and a foldable frame configured to position said rails. The system may further be deliverable through a catheter. The flexible member may be adjusted after deployment. The system may further include a guiding frame with features for conforming to anatomical structures
- In the drawings, identical reference numbers identify similar elements or acts. The sizes and relative positions of elements in the drawings are not necessarily drawn to scale. For example, the shapes of various elements and angles are not drawn to scale, and some of these elements are arbitrarily enlarged and positioned to improve drawing legibility. Further, the particular shapes of the elements as drawn, are not intended to convey any information regarding the actual shape of the particular elements, and have been solely selected for ease of recognition in the drawings.
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FIG. 1 is a schematic diagram of a treatment system according to one illustrated embodiment, including a medical device with a control handle, tissue anchors, and anchor guiding mechanism -
FIG. 2 is a cutaway diagram of a heart showing a medical device according to one illustrated embodiment percutaneously placed in a left atrium of the heart. -
FIG. 3 is a diagram showing an example of a helical anchor. -
FIG. 4 is a diagram showing an example of a multi-barbed anchor that is encapsulated and an example of a multi-barbed anchor that is not encapsulated. -
FIG. 5 is a diagram showing examples of helical anchors and barbed anchors embedded in tissue -
FIG. 6 is a diagram showing examples of anchors on a guided rail. -
FIG. 7 is a diagram showing an example of a helical anchor on a guided rail penetrating tissue. -
FIG. 8 is a diagram showing an example of a multi-barbed anchor on a guided rail penetrating tissue. -
FIG. 9 is a diagram of an anchor guiding frame according to one illustrated embodiment. -
FIG. 10 is a diagram of an anchor guiding frame compressed into a sheath according to one illustrated embodiment. -
FIG. 11 is a diagram of an expanded anchor guiding frame according to one illustrated embodiment. -
FIG. 12 is a diagram showing the distal end of the medical device according to one illustrated embodiment -
FIG. 13 is a diagram showing an example of anchors secured in a mitral valve annulus. -
FIG. 14 is a diagram showing an example of anchors and a cable used to constrict a mitral valve annulus. -
FIG. 15 is a diagram of a device for securing a cable that constricts a bodily orifice according to one illustrated embodiment. -
FIG. 16 is a diagram of a catheter with side slots according to one illustrated embodiment -
FIG. 17 is a diagram of a mechanism according to one illustrated embodiment for holding a tissue anchor captive -
FIG. 18 is a diagram of a mechanism according to one illustrated embodiment for restricting a tissue anchor from release until said anchor is fully embedded in tissue - In the following description, certain specific details are set forth in order to provide a thorough understanding of various embodiments of the invention. However, one skilled in the art will understand that the invention may be practiced without these details. In other instances, well-known structures have not been shown or described in detail to avoid unnecessarily obscuring descriptions of the embodiments of the invention.
- Unless the context requires otherwise, throughout the specification and claims which follow, the word “comprise” and variations thereof, such as, “comprises” and “comprising” are to be construed in an open, inclusive sense, that is as “including, but not limited to.”
- Reference throughout this specification to “one embodiment” or “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Thus, the appearances of the phrases “in one embodiment” or “in an embodiment” in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
- As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the content clearly dictates otherwise.
- It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.
- The headings provided herein are for convenience only and do not interpret the scope or meaning of the claimed invention.
- Overview of Device and Orifice Constriction Methods
- Various embodiments of medical apparatus which are percutaneously or intravascularly deployed and may be used for constricting a bodily orifice are described herein.
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FIG. 1 shows amedical device 100 according to one illustrated embodiment. - The
medical device 100 may be used to deploy tissue anchors 107 and aflexible cable 111. The tissue anchors 107 may be secured to the annulus of an orifice and theflexible cable 111 may be used to constrict the orifice by pulling theanchors 107 inward. Themedical device 100 comprises a flexibleanchor guiding frame 108 that may be used to guide tissue anchors 107 to target positions on the orifice annulus. The anchor guiding frame may be made of a material such as Nitinol. The guidingframe 108 shown inFIG. 1 is comprised of threeguide wires 112—one for each of the tissue anchors 107 shown. The guiding frame may include a different number of guide wires if more tissue anchors are desired. Theguide wires 112 shown preferably have hinges 113 and may be connected withsmall loops 109. The hinges 113 andloops 109 enable the guiding frame to fold up to fit inside a catheter and to expand to extend across an orifice. Both thehinges 113 andloops 109 may be replaced by other mechanisms that enable bending. Themedical device 100 typically has an articulatingmechanism 106 that enables correctly orienting the anchor guiding mechanism during deployment of tissue anchors 107. The articulatingmechanism 106 is preferably able to bend in any direction. The control knobs 103 and 104 may be used to control the bending of the articulatingmechanism 106 using cables that are carried in the longflexible tube 105. - The
medical device 100 shown comprises a longflexible tube 105 which extends from the articulatingmechanism 106 to the medicaldevice control mechanism 114 located at the proximal end of the catheter.Control mechanism 114 may consist ofcontrol knobs release rods 101, pushtubes 102, and guidewires 112. Additional controls may be required for other embodiments. Theflexible tube 105 may have multiple lumens.Multi-lumen push tubes 102, guidewires 112,release rods 101,cable 111, and other mechanisms may be carried inflexible tube 105. In the embodiment given, eachpush tube 102 has two lumens. Aguide wire 112 is carried in a first lumen and arelease rod 101 is carried in a second lumen. Anchor s 107 are attached distal tips ofrelease rods 101. Theanchor 107 may be inserted into the annulus of an orifice by advancing thepush tube 102 along theguide wire 112 and advancing or rotating therelease rod 101 carried in thepush tube 102 at the same rate. Theanchor 107 may advance past thehinge 113 and embed into the annulus of the orifice to be constricted. Once theanchor 107 is embedded, therelease rod 101 attached to the anchor may be retracted while thepush tube 102 is held in place. Retraction of therelease rod 101 causes theanchor 107 to detach from the distal tip of therelease rod 101 and remain embedded in the tissue. Other embodiments may use different methods for releasing the tissue anchors 107. -
FIG. 2 shows a medical device useful in constricting a bodily orifice, for example a mitral valve, according to one illustrated embodiment. - The medical device may be percutaneously and/or intravascularly inserted into a portion of the
heart 212, for example in aleft atrium 206 of theheart 212. In this example, the medical device is delivered via acatheter 202 inserted via theinferior vena cava 204 and penetrating thetransatrial septum 213 from aright atrium 203. Thecatheter 202 is preferably under 8 mm in diameter. - The flexible
anchor guiding frame 214 expands after being delivered via thecatheter 202 into a shape that preferably enables the tissue anchors 207 to be delivered to the desired position on themitral annulus 209. The flexibleanchor guiding frame 214 may be moved into the correct orientation by adjusting the shape of the articulatingmechanism 205, advancing or retractingflexible tube 201, or rotatingflexible tube 201. The flexibleanchor guiding frame 214 preferably has an overall shape that enables said frame to take on a desired orientation within a cavity by conforming to the shape or being affected by the movement of anatomical features. Such a property is known as “self-locating”. Minimal insertion force and operator guidance is typically needed to properly position the anchor guiding mechanism. The flexibleanchor guiding frame 214 may also have specific features which cause it to orient correctly based on the position of an anatomical feature, such as themitral valve leaflets 211. An example of such a feature is given byalignment fin 215.Alignment fin 215 is attached rigidly to flexibleanchor guiding frame 214 and shaped so that it may be deflected to a particular orientation by an anatomical feature, such asmitral valve leaflets 211. As the flexibleanchor guiding frame 214 is advanced toward an anatomical feature, such as themitral valve annulus 209, the shape or motion of an anatomical feature, such as themitral valve leaflets 211, may causealignment fin 215, and thus attached flexibleanchor guiding frame 214, to rotate or translate to a desired orientation or location. - The
anchors 207 may be inserted into theannulus 209 by advancing thepush tubes 216 along theguide wires 112. Theanchors 207 may advance past thebend 208 and embed into theannulus 209. The embedded anchors 207 may then be released from thepush tubes 216. Theflexible cable 210 connecting theanchors 207 may then be tightened and secured to constrict themitral annulus 209. -
FIG. 3 shows an example of a tissue anchor according to one illustrated embodiment. Thehelical tissue anchor 301 has a helical structure withsharp tip 303.Loop 302 may be used to connect to a mechanism for holding thetissue anchor 301 to a release rod.Loop 302 may also be used to attachtissue anchor 301 to a cable used for cinching the annulus of a bodily orifice. -
FIG. 4 shows an example of a tissue anchor according to one illustrated embodiment.Tissue anchor 403 is shown in a compressed configuration andtissue anchor 406 is shown in an expanded configuration. The tissue anchors 403, 406 comprisemultiple barbs 408. Themultiple barbs 408 may be compressed into constrictingtube 404 as shown fortissue anchor 403. Compression ofbarbs 408 into constrictingtube 404 enables the anchor to move more readily through a catheter and also to be inserted more readily into tissue. -
Tissue anchor 403 may comprise ahole 409 that may be used to attach said anchor to acable 401 used for cinching the annulus of a bodily orifice.Constricting tube 404 may comprise aslot 402 to allowanchor 403 to be ejected from constrictingtube 404 in the case wherehole 409 is mounted on a protruding flange. -
Tissue anchor 406 may comprise ahole 407 that may be used to connect said anchor to releaserod 405.Release rod 405 may be carried in a lumen ofpush tube 410. If constrictingtube 404 is extended overhole 407 as shown foranchor 403,release rod 405 is held captive inhole 407 by the wall oftube 404. If constrictingtube 404 is retracted to not coverhole 407, as shown fortissue anchor 406,release rod 405 is not held captive inhole 407 and said tissue anchor may become disconnected from constrictingtube 404 andrelease rod 405. -
Tissue anchor 406 may be disconnected fromrelease rod 405 andbarbs 408 may be uncompressed by retracting constrictingtube 404 relative to therelease rod 405 andtissue anchor 406. Retracting constrictingtube 404 past the tips ofbarbs 408 causes said barbs to be released and expand. Retracting constrictingtube 404past hole 407 may releasetissue anchor 406. -
FIG. 5 shows examples of tissue anchors embedded in tissue.Tissue anchor 501 is a helical anchor embedded intissue 502.Tissue anchor 501 is embedded intissue 502 by rotating said anchor.Tissue anchor 505 is a multi-barbed anchor embedded intissue 502.Tissue anchor 505 is embedded intissue 502 by pushing the anchor into the tissue.Barbs 504 provide resistance to restrict thetissue anchor 505 from being extracted. -
FIG. 6 shows examples of anchors guided by a rail. -
Multi-lumen push tube 600 may slide overguide rail 601.Tissue anchor 602 may be temporarily attached tomulti-lumen push tube 600 by constrictingtube 606 and a release rod (not shown). Slidingpush tube 600 alongguide rail 601 enablestissue anchor 602 to be controllably delivered to a location proximate to guiderail 601.Tissue anchor 602 may be constructed or oriented in such a way thattissue anchor tip 607 slides along or very near to guiderail 601. Such orientation or construction enables the tip to be protected from obstructions in the catheter or body that may dull the tip. Also, such orientation or construction protects areas of tissue proximate the guide rail from inadvertent, damaging contact with thesharp tip 607 oftissue anchor 602. - Single-
lumen push tube 603 may slide overguide rail 601.Helical tissue anchor 604 also may slide overguide rail 601 and may be temporarily attached to single-lumen push tube 603 bylatch mechanism 609.Latch mechanism 609 may be fastened to anchor 604 by a friction fitting that is released under sufficient axial force. This assembly enablestissue anchor 604 to be controllably delivered to a location proximate to guiderail 601.Tissue anchor 604 may be constructed or oriented in such a way thattissue anchor tip 608 slides along or very near to guiderail 601. Such orientation or construction enables the tip to be protected from obstructions in the catheter or body that may dull the tip. Also, such orientation or construction protects areas of tissue proximate the guide rail from inadvertent, damaging contact with the sharp tip oftissue anchor 608. -
FIG. 6 shows examples of two particular types of anchors being guided by a rail. However, to those skilled in the art, it is apparent that many other types of anchors could also be deployed with the aid of a guide rail as well. -
FIG. 7 shows a helical anchor according to one illustrated embodiment. -
Helical tissue anchor 702 is shown partially deployed intotissue 708. The location that anchor 702 enters the tissue may be determined by the position ofguide rail 704.Bend 707 inguide rail 704 may be positioned at the approximate location where theanchor 702 is to be deployed into the tissue.Bend 707 inguide rail 704 may comprise a hinge, a flexure, or one of many other joints.Tissue anchor 702 is deployed by rotatingpush tube 703. The rotation oftissue anchor 702 at the position of thebend 707 causes anchor 702 to spiral offguide rail 704 and intotissue 708. -
Helical tissue anchor 705 is shown fully deployed intotissue 708, but still connected to latchmechanism 709. In the fully deployed position,anchor 705 may no longer wrap aroundguide rail 704. Whenanchor 705 is still connected to latchmechanism 709, it may be readily retracted bycounter-rotating push tube 703. -
Helical tissue anchor 706 is shown fully deployed intotissue 708 and disconnected from tolatch mechanism 709.Latch mechanism 709 may become disconnected fromanchor 706 by retractingpush tube 703 or releasinglatch mechanism 709 with the addition of another cable to trigger a release mechanism. -
FIG. 8 shows an example of a multi-barbed anchor being deployed in tissue according to one illustrated embodiment. -
Multi-barbed tissue anchor 805 is shown fully inserted intotissue 804, but still encapsulated by constrictingtube 809. The location that anchor 805 enters the tissue may be determined by the position ofguide rail 803. Abend 810 inguide rail 803 may be positioned at the approximate location where theanchor 805 is to be deployed into thetissue 804. Thebend 810 inguide rail 803 may be constructed using a hinge, a flexure, or one of many other methods.Tissue anchor 805 is deployed by advancingpush tube 802 overguide rail 803. Ifanchor 805 is encapsulated by constrictingtube 809, it may be readily retracted by retractingpush tube 802. -
Multi-barbed tissue anchor 808 is shown fully inserted intotissue 804, but disconnected from constrictingtube 811 andrelease rod 806.Anchor 808 is preferably retracted slightly beforerelease rod 806 is disconnected in order to causebarbs 807 to expand.Tissue anchor 808 may be disconnected fromrelease rod 806 andbarbs 807 may be expanded by retracting constrictingtube 809 relative to therelease rod 806 andtissue anchor 808. Retracting constrictingtube 811 past the tips ofbarbs 807 causes said barbs to be released and expand. -
FIG. 9 shows an example of an anchor guiding frame according to one illustrated embodiment. - Anchor guiding
frame 901 is used to guide tissue anchors to correct insertion points. Theanchor guiding frame 901 shown comprises threeguide rails 905, but said frame may comprise more or fewer guide rails. Theanchor guiding frame 901 embodiment given shows all guidewires 905 connected at the bottom of the frame. An anchor guiding frame is not required to have all guide wires connected together, although it is often preferable to do so to create a framework that enables anchors to be positioned relative to each other and to anatomical features. An anchor guiding frame may have multiple disconnected groups of connected guide wires. - The anchor guiding frame preferably is capable of folding to enable delivery via a catheter.
Guide wires 905 may be hinged atbends 902 and guidewire connection point 904 to enable folding.Loop 903 facilitates folding and also acts as a spring to enable unfolding of theanchor guiding frame 901. -
Guide wires 905 may be formed to havebend 906 when no external forces are being applied. Whenguide wires 905 are carried in a catheter with an articulating mechanism shaped into a curve as shown inFIG. 2 , the forces exerted on the guide wire by the catheter and articulating mechanism will causebend 906 to align with the curve in the articulating mechanism. Such alignment causesanchor guiding frame 901 to rotate to a desired position relative to the catheter orientation. Bend 906 may also be formed to assist in curving the articulating mechanism in a particular way. - An anchor guiding frame may also contain additional features which use anatomical features or movement to assist in orientation of said anchor guiding mechanism. An example of such a feature is give by
alignment fin 907.Alignment fin 907 is attached rigidly to flexibleanchor guiding frame 901 and shaped so that it may be deflected by an anatomical feature, such as mitral valve leaflets, to a particular orientation. As the flexibleanchor guiding frame 901 is advanced toward an anatomical feature, such as the mitral valve annulus, the shape or motion of an anatomical feature, such as the mitral valve leaflets, may causealignment fin 907, and thus flexibleanchor guiding frame 901, to rotate to a desired orientation. -
FIG. 10 shows an anchor guiding frame folded for delivery inside a catheter according to one illustrated embodiment. - The anchor guiding frame comprising
guide wires 1004 may be folded insidecatheter 1001.Hinges 1006 andloop 1007 enhance folding of the anchor guiding mechanism. In the embodiment given, tissue anchors 1003 fit between theguide wires 1004 in the folded configuration.Protective anchor cap 1005 holds and covers the sharp tips of tissue anchors 1003 and may ensure that the tips do not catch or embed on the sides ofcatheter 1001.Protective anchor cap 1005 is held in place bycontrol wire 1002 -
FIG. 11 shows an anchor guiding frame in an expanded configuration according to one illustrated embodiment. - Anchor guiding
frame 1112 may self expand after exitingcatheter 1111.Loop 1106 may be formed to cause said frame to expand.Hinges 1105 facilitate separation of guide wires by about 20 to 45 mm. In the given embodiment, tissue anchors 1109 are held within the volume encompassed byanchor guiding frame 1112 which ensures theanchors 1109 do not accidentally impinge tissue. Also, the tissue anchors tips are held captive withinprotective anchor cap 1110. The anchor tips may be released by advancingcontrol wire 1103 and thereby also advancinganchor cap 1110. The anchor tips are no longer held captive ifanchor cap 1110 is advanced sufficiently to a point past the anchor tips. Asguide wires 1104 curve away fromanchor cap 1110, advancinganchors 1109 causes the anchor tips to move away from and avoidanchor cap 1110. - Articulating
mechanism 1107 is shown in a curved state. Articulatingmechanism 1107 is curved using wires (not shown) that are carried on opposing sides relative to the longitudinal axis of said mechanism and fixed to the distal end of said mechanism. Tensioning one wire causes the articulatingmechanism 1107 to arc in the direction of the side of said mechanism said tensioned wire is carried in. Using tensioned wires to curve an articulated joint as indicated is well known. However, for some situations, it is desirable to cause the gaps between links to open at a different rate. For example, when inserting articulatingmechanism 1107 into the left atrium, it may be preferable to cause the distal links, such aslink 1113 andlink 1114, to separate or bend prior to or more than the proximal links, such aslink mechanism 1107 to bend first, the distal links should be forced apart by springs with a higher spring constant than the springs between the proximal links. Another embodiment for enabling unequal separation of links is to control the shape of theguide wires 1104 that are routed through the articulatingmechanism 1107. The guide wires should have a preformed bend with a decreasing radius of curvature in the area fromproximal link 1115 todistal link 1114. -
FIG. 12 shows the configuration of the tissue anchors and push tubes at the distal tip of the medical apparatus according to one illustrated embodiment. For the sake of clarity,FIG. 12 omits showing guide wires and an anchor guiding frame that would typically be located at the distal tip of the medical apparatus. - The articulating
mechanism 1204 may comprisemultiple lumens 1208 through whichpush tubes 1202 are carried. In this particular embodiment, threelumens 1208 are shown, but other embodiments may comprise more or less. Pushtubes 1202 may also comprise multiple lumens. In this particular embodiment, eachpush tube 1202 has alumen 1201 in which a guide wire may be carried and a second lumen that carries the release rod (not shown) which is connected to the tissue anchors 1209.Constricting tubes 1205 may be mated into the distal end of said second lumen. All tissue anchors may be connected byflexible cable 1207. The flexible cable may also be carried within a separate lumen within the articulatingmechanism 1204.Lumens 1203 are used to carry cables that control the curvature of the articulatingmechanism 1204. -
FIG. 13 shows a cross section of the heart with an anchor guiding frame according to one illustrated embodiment positioned within the left atrium. - Anchor guiding
frame 1303 is shown self-located on themitral annulus 1304 within the left atrium. The tissueanchor deployment sites 1301 are preferably located on the mitral annulus and coincident with bends in the guide rails 1302.FIG. 13 shows threeguide rails 1302 andtissue deployment sites 1301 for simplicity; however, in many cases more deployment sites and guide rails are desirable. In such cases, it is a simple matter to add additional guide rails and anchor deployment sites to the disclosed embodiment. -
Alignment fin 1305 may fit betweenmitral valve leaflets 1306. The movement and anatomical structure of themitral valve leaflets 1306 exert force onalignment fin 1305 and assist in orienting theanchor guiding frame 1303 correctly -
FIG. 14 shows a cross section of the heart with an installed assembly capable of constricting the mitral valve annulus according to one illustrated embodiment. - Tissue anchors 1401, 1402, and 1403 are shown fully deployed on the
mitral annulus 1406. Tissue anchors may be connected byflexible cable 1405. Other mechanisms for connecting tissue anchors 1401, 1402, 1403 are possible. For example, rigid members, preferably with adjustable length, may be used to connect said anchors.Flexible cable 1405 may slide through holes on the tissue anchors 1401, 1402, 1403. -
Flexible cable 1405 may pass through ahollow spreader bar 1404.Hollow spreader bar 1404 provides support to keeptissue anchors flexible cable 1405 is shortened. Such support reduces undesired forces being applied to theaortic valve 1407. - Reducing the distance between tissue anchors 1401, 1402 and 1402, 1403 causes the anterior-posterior (A-P) annular dimension of the mitral valve to reduce and improves leaflet coaptation. Several methods may be used to reduce the distance between tissue anchors. A first method is to shorten the cable during the installation procedure by routing the
flexible cable 1405 throughfastener 1408, pulling the cable manually to be as tight as desired and crimpingfastener 1408.Fastener 1408 may also be constructed using a one way clutch so that theflexible cable 1405 can only be pulled through in one direction, in which case crimping is not required. A second method of reducing anchor separation is to include shorteningactuator 1409 between two anchors. In the case where shorteningactuator 1409 is included,flexible cable 1405 is split and attached to either end of the shortening actuator. One embodiment of shorteningactuator 1409 contains an element that is capable of changing length as a response to changes in an external magnetic field or in response to heating induced by a changing magnetic field. The element capable of changing lengths may be made of a highly magnetostrictive alloy such as Terfenol-D or from a Shape Memory Alloy (SMA) such as specially treated Nitinol. Embodiment of such actuators are described in U.S. Ser. No. 11/902,199. The element capable of changing lengths may be made of a spring under tension encapsulated in material that melts under low heat and solidifies at body temperature—such as a thermoplastic polymer. Current induced in a loop by an external magnetic field may be channeled through the spring. The current may heat the spring which will cause the polymer to soften and the spring length to contract. The contraction of the spring can be used to reduce the separation of the tissue anchors. Embodiments of such actuators are described in U.S. Ser. No. 11/905,771. - A closed, electrically conducting loop is required if shortening
actuator 1409 is to be responsive to heating or energy induced by a changing magnetic field. Such a loop may be achieved by using an electrically conductive material forflexible cable 1405 and ensuring an electrical contact between both ends offlexible cable 1405 that are connected to shorteningactuator 1409. -
FIG. 15 shows a cross section of a tool and fastener used to tighten and secure a cable according to one illustrated embodiment. -
Fastener 1507 may be used to tighten or secure cables being used to constrict a bodily orifice. Typically prior to attachment offastener 1507, tissue anchors have been placed, and a flexible cable has been connected to the tissue anchors.Cable end 1504 andcable end 1503 are typically carried incatheter sheath 1505 and routed outside the body.Cable end 1504 andcable end 1503 may be the two ends of one flexible cable. The portion of the cable not shown loops around the orifice to be constricted and is attached to the implanted tissue anchors used to secure the cable to the orifice. -
Cable end 1504 may be fed intohole 1511 and locked byferrule 1510 whilefastener 1507 is still outside the body.Cable end 1503 may be routed throughtaper lock 1509 whilefastener 1507 is still outside the body. -
Fastener 1507 may be attached tofastener positioning tube 1506.Cable end 1503 may be inserted throughslot 1502 and intofastener positioning tube 1506.Fastener 1507 andfastener positioning tube 1506 may be inserted intocatheter sheath 1505 and advanced untilfastener 1507 is proximate the annulus of the orifice to be constricted.Cable end 1503 may be pulled in a direction away fromfastener 1507, causing the cable to pull throughtaper lock 1509 and constrict the orifice. While the cable is being tightened and secured,fastener 1507 may be held byfastener positioning tube 1506.Taper lock 1509 restrictscable end 1503 from being pulled out the right side offastener 1507.Taper lock 1509 may haveteeth 1515 to gripcable end 1503.Taper lock 1509 may have a longitudinal slot to enable compression oftaper lock 1509 and constriction aroundcable end 1503.Spring 1508 may forcetaper lock 1509 into aconical hole 1514, causing it to tighten aroundcable end 1503. - When the orifice has been sufficiently constricted,
cable end 1503 may be severed usingcable cutting tube 1501.Cable cutting tube 1501 comprises a sharpenedend 1516.Cable cutting tube 1501 is shown in a retracted position. The cable cutting tube may slide inside offastener positioning tube 1506.Cable cutting tube 1512 is shown in the cable cutting position.Cable cutting tube 1512 may severcable end 1513 by forcingcable end 1513 against the end ofslot 1516. The cable end may be severed in other ways, including using a hot tip to melt through the cable. -
FIG. 16 shows a catheter with grooves, or side slots, and a mechanism for securing cables or wires in said side slots according to one illustrated embodiment. -
Catheter 1604 is shown withcables 1601 held withinlongitudinal groove 1603 on the inner surface of the tube wall bytube 1602. Thelongitudinal groove 1603 has a cross sectional shape that enablestube 1602 to be held captive.FIG. 16 shows a circular groove, but other shapes may be used.Tube 1602 carriescables 1601.Tube 1602 could also carry wires or tubes. Whentube 1602 is removed by pulling it out the end, as shown bycatheter 1607,cables 1605 are free to move into the central area of the tube.Tube 1602 can be reinserted overcables 1605 to again constrain them ingroove 1603. - Although
FIG. 16 showscatheter 1604 andcatheter 1607 with only onegroove 1603, it is possible to have many such grooves in a catheter and to secure a plurality of wires and tubes in said grooves. One of the reasons for securing cables or wires in grooves, or side slots, is to eliminate tangling of cables or wires during medical procedures. -
FIG. 17 is a cross sectional diagram of a mechanism for holding a tissue anchor captive according to one illustrated embodiment -
Tissue anchor 1703 may be held captive in constrictingtube 1706 byrelease rod 1704.Constricting tube 1706 may be inserted and secured to the distal end of one lumen ofpush tube 1701.Constricting tube 1706 may be held captive in the lumen byribs 1705. -
Tissue anchor 1703 may be released from constrictingtube 1706 by retractingpush tube 1701 and constrictingtube 1706 relative to releaserod 1704. As the distal end of constrictingtube 1706 clearshole 1707,release rod tip 1708 will pop out ofhole 1707 andtissue anchor 1703 will no longer be held captive. -
Lumen 1702 ofpush rube 1701 may be used to slide over a guide wire. -
FIG. 18 is a cross sectional diagram of a mechanism for restricting a tissue anchor from release until anchor is fully embedded in tissue according to one illustrated embodiment - An additional benefit is provided if the medical device for constricting a bodily orifice does not release tissue anchors until they are fully embedded in the tissue. It is possible to achieve this benefit by adding an
additional latch -
Tissue anchor 1802 is shown prior to deployment.Tissue anchor 1802 may not be released from constrictingtube 1805 by retractingpush tube 1803 and constrictingtube 1805 relative to releaserod 1804 becauselatch 1806 protrudes intonotch 1801. -
Tissue anchor 1808 is shown fully deployed intotissue 1812. Astissue anchor 1808 was deployed intotissue 1812, the surface oftissue 1812 causeslever 1811 to bend. Whenlever 1811 is bent,latch 1810 clearsnotch 1813. Oncelatch 1810 clearsnotch 1813,tissue anchor 1808 may be released from constrictingtube 1809 - The various embodiments described above can be combined to provide further embodiments. All of the U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications and non-patent publications referred to in this specification and/or listed in the Application Data Sheet are incorporated herein by reference, in their entirety. Aspects of the invention can be modified, if necessary, to employ systems, circuits and concepts of the various patents, applications and publications to provide yet further embodiments of the invention.
- These and other changes can be made to the invention in light of the above-detailed description. In general, in the following claims, the terms used should not be construed to limit the invention to the specific embodiments disclosed in the specification and the claims, but should be construed to include all medical treatment devices in accordance with the claims. Accordingly, the invention is not limited by the disclosure, but instead its scope is to be determined entirely by the following claims.
Claims (20)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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US12/120,195 US20090287304A1 (en) | 2008-05-13 | 2008-05-13 | Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve |
PCT/US2009/043612 WO2009140268A1 (en) | 2008-05-13 | 2009-05-12 | Medical device for constricting tissue or a bodily orifice, for example a mitral valve |
US12/899,407 US9744038B2 (en) | 2008-05-13 | 2010-10-06 | Medical device for constricting tissue or a bodily orifice, for example a mitral valve |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US12/120,195 US20090287304A1 (en) | 2008-05-13 | 2008-05-13 | Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve |
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US12/899,407 Division US9744038B2 (en) | 2008-05-13 | 2010-10-06 | Medical device for constricting tissue or a bodily orifice, for example a mitral valve |
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US12/899,407 Active US9744038B2 (en) | 2008-05-13 | 2010-10-06 | Medical device for constricting tissue or a bodily orifice, for example a mitral valve |
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US12/899,407 Active US9744038B2 (en) | 2008-05-13 | 2010-10-06 | Medical device for constricting tissue or a bodily orifice, for example a mitral valve |
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WO2009140268A1 (en) | 2009-11-19 |
US20110022166A1 (en) | 2011-01-27 |
US9744038B2 (en) | 2017-08-29 |
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