US20110028880A1

US20110028880A1 - Patch

Info

Publication number: US20110028880A1
Application number: US12/919,739
Authority: US
Inventors: Naoyuki Uchida; Naoko Fujita
Original assignee: Hisamitsu Pharmaceutical Co Inc
Current assignee: Hisamitsu Pharmaceutical Co Inc
Priority date: 2008-02-27
Filing date: 2009-02-09
Publication date: 2011-02-03
Also published as: JP6054013B2; JPWO2009107479A1; US20110002976A1; EP2258355A1; EP2258369A4; US8871249B2; EP2258369B1; EP2255809A4; ES2536206T3; JPWO2009107477A1; JP5485135B2; EP2255809B1; US20110008398A1; JP5537412B2; EP2258355A4; WO2009107477A1; ES2648197T3; WO2009107479A1; US8580281B2; WO2009107476A1

Abstract

Provided is a patch containing a drug, a metal salt, an adsorbent and a pressure-sensitive adhesive base, where the metal salt is a salt containing a substance capable of forming a drug salt by bonding to the drug or a component thereof, a content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed, and the adsorbent is an adsorbent that adsorbs a polar solvent contained in the patch.

Description

TECHNICAL FIELD

The present invention relates to a patch.

BACKGROUND ART

A wide variety of drug-containing patches are developed in the expectations of reducing adverse reaction due to the avoidance of gastrointestinal tissue absorption of the drug and first-time passage to the liver and the improvement of patient compliance.
However, not all the drugs exhibit good tissue absorption in transdermal administration, transmembrane administration, transnail administration, or the like, and thus various studies have been conducted to enhance the tissue absorption of the drugs.
The drugs are distributed in the form of acid addition salt in the market from viewpoints of the handleability and stability thereof. However, when a drug acid addition salt is directly applied to the transdermal administration, or the like, it is generally known that the tissue absorption tends to be decreased. On the other hand, it is also known that the free base (free form) of a drug is preferable in view of the tissue absorption.
Accordingly, techniques wherein an acid addition salt of a drug used for a patch is neutralized (desalted) using a metal hydroxide such as sodium hydroxide, which is a strong base to completely desalt the acid addition salt have been studied (e.g., Patent Documents 1 and 2), but all of these techniques are those in which the formed metal salt is either removed by carrying out filtration beforehand or mixed with a pressure-sensitive adhesive base without further treatment.

Patent Document 1: Japanese Unexamined Patent Application Publication No. 2007-16020

Patent Document 2: Japanese Unexamined Patent Application Publication No. 2002-509874

DISCLOSURE OF THE INVENTION

Problem to be Solved by the Invention

However, the present inventors found that when an easier production process wherein the free form of a drug and a metal salt (sodium chloride, or the like) are formed by the neutralization reaction of an acid addition salt of the drug and the metal salt is mixed with a pressure-sensitive adhesive base without being removed by filtration is employed, the metal salt formed by the neutralization reaction sometimes precipitates in the form of crystal, which aggregates and grows over time adversely affecting the production efficiency, product stability and product properties of a patch.
Thus, an object of the present invention is to provide a patch with suppressed over-time aggregation and growth of the metal salt formed when a drug salt is neutralized.

Means for Solving Problem

The present inventors conducted extensive studies to accomplish the above object and found that a salt derived from a drug acid addition salt formed after a neutralization reaction has a possibility to aggregate and grow around a small amount of the residue of a polar solvent (water, methanol, ethanol, or the like) used when a patch is produced or the neutralization reaction is carried out, and further found that the aggregation and growth can be suppressed by containing an adsorbent in a pressure-sensitive adhesive layer.
More specifically, the present invention is to provide a patch comprising a drug, a metal salt, an adsorbent and an pressure-sensitive adhesive base, the metal salt contains a substance capable of forming a drug salt by bonding to the drug or a component thereof, the content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed; and the adsorbent is an adsorbent that adsorbs a polar solvent comprised in the patch.
With reference to an example of a drug being a basic drug, the metal salt contained in the patch of the present invention is now described. When expressing a basic drug as “A”, a substance capable of forming a drug acid addition salt by bonding to the drug “A” as “HX” and a drug acid addition salt as “A.HX”, the neutralization reaction mentioned above can be expressed as A.HX+MOH →A+MX+H₂O and the salt formed as a result of the neutralization reaction is expressed as “MX”. The metal salt in the patch of the present invention is the “MX” in this example and contains the component “X” of the substance “HX” capable of forming a drug salt by bonding to the drug “A”. Further, the content of the “MX” is not greater than the number of moles of the “HX” in the “A.HX”.
The adsorbent contained in the patch of the present invention is the one which adsorbs polar solvent such as the water produced by the above neutralization reaction and remaining in the patch, the water used in the production process and remaining in the patch, methanol and ethanol and consists of an inorganic and/or organic substance.
In the present invention, since the kind and content of a metal salt are limited as above and an adsorbent for adsorbing a polar solvent is also contained, it is considered that the over-time aggregation and growth of a metal salt formed when a patch is produced by neutralizing a drug salt are suppressed, thereby enhancing the production efficiency, product stability and product properties of the patch.
The metal salt contained in the patch of the present invention may be those formed during the production as described above, but may also be those formed in the patch after the production (i.e., during storage after the production and before use).
In the present invention, the drug is preferably a basic drug, and the metal salt is preferably at least one selected from the group consisting of metal chlorides, metal bromides, metal iodides and organic acid metal salts. A particularly preferable metal salt is at least one selected from the group consisting of sodium chloride, calcium chloride, aluminum chloride, stannous chloride, ferric chloride, magnesium chloride, potassium chloride, sodium citrate, sodium oxalate, sodium tartrate, sodium bromide and sodium succinate.
A preferable adsorbent is at least one adsorbent selected from the group consisting of talc, kaoline, bentonite, hydrous silica, fumed silica, polyvinylpyrrolidone, propylene glycol, amino alkyl methacrylate copolymers, crospovidone, carboxy vinyl polymers, lactic acid, acetic acid, zinc oxide; dextrin and dried aluminum hydroxide gel, owing to a high adsorbability of a polar solvent contained in the patch.
Since the effects of the present invention are significantly achieved and a wide variety of potential ingredients are applicable, it is preferred that the basic drug be the one generated from a basic drug acid addition salt and that the basic drug acid addition salt be hydrochloride, acetate, sulfate, maleate, oxalate, citrate, hydroiodide, mesylate, tartrate or succinate of a basic drug.
The patch of the present invention may be applied directly to the skin as a so-called plaster, or may be applied as a plaster agent by forming an pressure-sensitive adhesive layer on a backing layer and containing the patch in the pressure-sensitive adhesive layer.

EFFECT OF THE INVENTION

According to the present invention, a patch in which the over-time aggregation and growth of a metal salt formed even when a drug salt is neutralized are suppressed is provided.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a perspective view showing a preferable embodiment of a patch of the present invention.

DESCRIPTION OF SYMBOLS

1. Patch, 2. Backing layer, 3. Pressure-sensitive adhesive layer, 4. Release sheet

BEST MODES FOR CARRYING OUT THE INVENTION

Hereinafter, preferable embodiments are described in detail with reference to the drawing. A part of the drawing is depicted in a larger manner for easier understanding, and the size ratio does not necessarily correspond with that of the description.
FIG. 1 is a perspective view showing a preferable embodiment of the patch of the present invention. In FIG. 1, a patch 1 is provided with a backing layer 2, a pressure-sensitive adhesive layer 3 laminated on the backing layer 2, and a release sheet 4 attached on the pressure-sensitive adhesive layer 3. The pressure-sensitive adhesive layer 3 contains a drug, a metal salt and an adsorbent. Further, the metal salt contains a substance capable of forming a drug salt by bonding to the drug or a component thereof, and the content of the metal salt is not greater than the number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed in the same mole as the drug contained in the patch.
The pressure-sensitive adhesive layer 3 may be laminated to two or more layers, and may be laminated not only on one side but also on both sides of the backing layer 2. When applying the patch, the release sheet 4 is removed before use.
The material for the backing layer 2 is not limited insofar, as it is typically usable for patches, and elastic or non-elastic materials can be used. Specific examples of the preferably used material include films or sheets formed with a synthetic resin such as polyethylene terephthalate, polyethylene, polypropylene, polybutadiene, ethylene vinyl acetate polymer, polyvinyl chloride, polyester, nylon, and polyurethane, or laminates thereof, porous membranes, foams, fabrics and nonwoven fabrics and paper materials.
The pressure-sensitive adhesive layer 3 contains a pressure-sensitive adhesive base. The pressure-sensitive adhesive base is not limited insofar as it can be a base for the pressure-sensitive adhesive layer 3, and examples include acrylic pressure-sensitive adhesive bases, rubber pressure-sensitive adhesive bases, and silicone pressure-sensitive adhesive bases.
Examples of the preferably usable acrylic pressure-sensitive adhesive base include homopolymer or copolymer of (meth)acrylate, and copolymer of alkyl (meth)acrylate ester and other functional monomers. (Meth)acryl means acryl or methacryl.
Examples of the preferably used rubber pressure-sensitive adhesive base include natural rubbers, synthetic rubbers, styrene-isoprene-styrene block copolymer (hereinafter abbreviated as “SIS”), isoprene rubber, polyisobutylene (hereinafter abbreviated as “PIB”), styrene-butadiene-styrene block copolymer (hereinafter abbreviated as “SBS”), styrene-butadiene rubber (hereinafter abbreviated as “SBR”) and polybutene, and the rubber pressure-sensitive adhesive base is typically used by adding a tackifier.
Usable silicone pressure-sensitive adhesive base are those containing polydimethyl siloxane or the like as a main component, and these are typically used by adding a tackifier such as MQ resin.
Among the pressure-sensitive adhesive bases listed above, an acrylic ester copolymer or SIS to which a tackifier is added is particularly preferably used.
These pressure-sensitive adhesive bases may be used singly, or two or more may be used in combination. The amount of a pressure-sensitive adhesive base to be added is preferably 10 to 95% by mass, more preferably 15 to 80% by mass, particularly preferably 20 to 70% by mass, on the basis of the total mass of the pressure-sensitive adhesive layer 3 when considering the formation of the pressure-sensitive adhesive layer 3 and the tissue permeability of the active ingredients.
The pressure-sensitive adhesive layer 3 contains a drug. The drug includes a drug salt which has become a free form by a neutralization reaction and a drug salt remained in the form of salt due to an incomplete neutralization.
The drug used for the production of the patch 1 is not limited, and examples include hypnotic/sedative agents (flurazepam hydrochloride, rilmazafone hydrochloride, phenobarbital, amobarbital, medetomidine hydrochloride, dexmedetosine hydrochloride, etc.), antipyretic/anti-inflammatory/analgesic agents (butorphanol tartrate, perisoxal citrate, acetaminophen, mefenamic acid, diclofenac sodium, aspirin, alclofenac, ketoprofen, flurbiprofen, naproxen, piroxicam, pentazocine, indomethacin, glycol salicylate, aminopyrine, loxoprofen, meloxicam, lomoxicam, etc.), steroidal anti-inflammatory agents (hydrcortisone, prednisolone, dexamethasone, betamethasone, etc.), stimulant (methamphetamine hydrochloride, methylphenidate hydrochloride, etc.), psychoneurotic agents (imipramine hydrochloride, diazepam, sertraline hydrochloride, fluvoxamine maleate, paroxetine hydrochloride, citalopram hydrobromide, fluoxetine hydrochloride, alprazolam, haloperidol, clomipramine, amitriptyline, desipramine, amoxapine, maprotiline, meanserin, setiptiline, trazadone, lofepramine, milnacipran, duloxetine, venlafaxine, chlorpromazine hydrochloride, thioridazine, diazepam, meprobamate, etizolam, etc.), hormone agents (estradiol, estriol, progesterone, norethisterone acetate, metelonone acetate, testosterone, etc.), local anesthesia agents (lidocaine hydrochloride, procaine hydrochloride, tetracaine hydrochloride, dibucaine hydrochloride, propitocaine hydrochloride, etc.), agents for urinary organs (oxybutynin hydrochloride, tamsulosin hydrochloride, propiverine hydrochloride, imidafenacin, solifenacin succinate, etc.), skeletal muscle relaxants (tizanidine hydrochloride, eperisone hydrochloride, pridinol mesylate, suxamethonium chloride, etc.), agents for sexual organs (ritodrine hydrochloride, meluadrine tartrate), antiepileptic agents (sodium valproate, clonazepam, carbamazepine, etc.), agents for autonomic nerve (carpronium chloride, neostigmine bromide, bethanechol chloride, etc.), anti-Parkinson's disease agents (pergolide mesylate, bromocriptine mesylate, trihexyphenidyl hydrochloride, amantadine hydrochloride, ropinirole hydrochloride, talipexole hydrochloride, cabergoline, droxidopa, piperiden, selegiline hydrochloride, etc.), diuretic agents (hydroflumethiazide, furosemide, etc.), respiratory stimulants (loberine hydrochloride, dimorpholamine, naloxone hydrochloride, etc.), anti-migraine agents (dihydroergotamine mesylate, sumatriptan, ergotamine tartrate, flunarizine hydrochloride, cyproheptadine hydrochloride, etc.), antihistamines (clemastine fumarate, diphenhydramine tannate, chlorpheniramine maleate, diphenylpyraline hydrochloride, promethazine, etc.), bronchodilators (tulobuterol hydrochloride, procaterol hydrochloride, salbutamol sulfate, clenbuterol hydrochloride, fenoterol hydrobromide, terbutaline sulfate, isoprenaline sulfate, formoterol fumarate, etc.), cardiotonic agents (isoprenaline hydrochloride, dopamine hydrochloride, etc.), coronary vasodilators (diltiazem hydrochloride, verapamil hydrochloride, isosorbide dinitrate, nitroglycerin, nicorandil, etc.), peripheral vasodilator (nicametate citrate, tolazoline hydrochloride, etc.), smoking cessation aids (nicotin, varenicline tartrate, etc.), agents for circulation organs (flunarizine hydrochloride, nicardipine hydrochloride, nitrendipine, nisoldipine, felodipine, amlodipine besilate, nifedipine, nilvadipine, manidipine hydrochloride, benidipine hydrochloride, enalapril maleate, democapril hydrochloride, alacepril, imidapril hydrochloride, cilazapril, lisinopril, captopril, trandolapril, perindopril erbumine, atenolol, bisoprolol fumarate, metoprolol tartrate, betaxolol hydrochloride, arotinolol hydrochloride, celiprolol hydrochloride, carvedilol, carteolol hydrochloride, bevantolol hydrochloride, valsartan, candesartan cilexetil, losartan potassium, clonidine hydrochloride, etc.), arrhythmic agents (propranolol hydrochloride, alprenolol hydrochloride, procainamide hydrochloride, mexitilene hydrochloride, nadolol, disopyramide, etc.), anti-malignant ulcer agents (cyclophosphamide, fluorouracil, degafur, procarbazine hydrochloride, ranimustine, irinotecan hydrochloride, fluridine, etc.), anti-lipaemia agents (pravastatin, simvastatin, bezafibrate, probucol, etc.), hypoglycemic agents (glibenclamide, chlorpropamide, tolbutamide, glymidine sodium, glybuzole, buformin hydrochloride, etc.), anti-peptic ulcer drugs (proglumide, cetraxate hydrochloride, spizofurone, cimetidine, glycopyrronium bromide, etc.), choleretic agents (ursodesoxycholic acid, osalmid, etc.), gastrointestinal motility enhancers (domperidone, cisapride, etc.), hepatic disease agents (tiopronin, etc.), anti-allergic agents (ketotifen fumarate, azelastine hydrochloride, etc.), antiviral agents (acyclovir, etc.), anti-vertigo agents (betahistine mesylate, difenidol hydrochloride, etc.), antibiotics (cephaloridine, cefdinir, cefpodoxime proxetil, cefaclor, clarithromycin, erythromycin, methylerythromycin, kanamycin sulfate, cycloserine, tetracycline, benzylpenicillin potassium, propicillin potassium, cloxacin sodium, ampicillin sodium, bacampicillin hydrochloride, carbenicillin sodium, chloramphenicol, etc.), agents for habitual intoxication (cyanamide, etc.), anorectic agents (mazindol, etc.), chemotherapic agents (isoniazid, ethionamide, pyrazinamide, etc.), clotting enhancers (ticlopidine hydrochloride, warfarin potassium, etc.), anti-Alzheimer agents (physostigmine, donepezil hydrochloride, tacrin, arecoline, xanomeline, galantamine hydrobromide, etc.), serotonin receptor antagonist antiemetic agents (ondansetron hydrochloride, granisetron hydrochloride, ramosetron hydrochloride, azasetron hydrochloride, etc.), gout agents (colchicine, probenecid, sulfinpyrazone, etc.), narcotic painkillers (morphine sulfate, morphine hydrochloride, codeine phosphate, cocaine hydrochloride, pethidine hydrochloride, etc.), and antifungal drug (terbinafine hydrochloride, butenafine hydrochloride, amorolfine hydrochloride, neticonazole hydrochloride, miconazole nitrate, luliconazole, itraconazole, liranaftate, etc).
These drugs can be used in combination of two or more as necessary if no inconvenience is caused by the interaction. Further, considering that the sufficient potency as a patch is attained, the product properties and tissue absorption, the drug is added in a proportion of preferably 0.5 to 50% by mass, particularly preferably 1 to 30% by mass, on the basis of the total mass of the pressure-sensitive adhesive layer 3.
The drug is preferably a basic drug and more preferably a basic drug generated from an acid addition salt. Examples of the acid addition salt form include hydrochloride, acetate, sulfate, maleate, oxalate, citrate, hydroiodide, hydrobromate, mesylate, tartrate, and succinate.
The pressure-sensitive adhesive layer 3 contains a metal salt containing a substance capable of forming a drug salt by bonding to the drug or a component thereof. Such a metal salt is preferably those formed during production steps. Since the drug is preferably a basic drug generated from an acid addition salt, it is desirable to use an acid addition salt of a basic drug as a starting material, cause a neutralization reaction of the drug by mixing the salt with a neutralizer, allow the free form of the drug having a higher tissue absorption to be present in the pressure-sensitive adhesive layer 3 and cause the metal salt produced as a result of the neutralization reaction of the drug to be also contained therein.
The type of the metal salt produced as a result of the neutralization reaction (desalting reaction) is determined by a drug salt and a neutralizer for neutralizing the drug salt. The metal salt produced when neutralizing an acid addition salt of a basic drug is preferably any of metal chloride, metal bromide, metal iodide or organic acid metal chloride, and particularly preferably at least one of sodium chloride, calcium chloride, aluminum chloride, stannous chloride, ferric chloride, magnesium chloride, potassium chloride, sodium citrate, sodium oxalate, sodium tartrate, sodium bromide and sodium succinate.
The neutralizer used for the neutralization reaction is not limited, but when a basic drug produced from an acid addition salt is used, a strong base is suitable for completely desalting an acid addition salt of a basic drag, with a hydroxide of an alkali metal is particularly preferably used. Specific examples of the neutralizer include sodium hydroxide, potassium hydroxide, and magnesium hydroxide, with sodium hydroxide being particularly preferable among these. The neutralizer is added to convert a basic drug as a whole or a part to the state of free base (free form). To obviate the decomposition of the drug caused by an excessive amount of a neutralizer at this step, the neutralizer is preferably added within a range from 0.5 to 4 equivalent amounts to the equivalent amount of the drug acid base. The addition may be carried out once during the production steps, or carried out several times in a divided manner.
The patch 1 produced via a neutralization reaction contains a metal salt formed as a result of the neutralization in the pressure-sensitive adhesive layer 3.
The metal salt present in the pressure-sensitive adhesive layer 3 is likely to aggregate and grow around a small amount of the residue of a polar solvent (water, methanol, ethanol, etc.) used during the production of the patch and the neutralization reaction, but the aggregation and growth of the metal salt can be suppressed by allowing the pressure-sensitive adhesive layer 3 to contain an adsorbent. Further, the crystal can be dispersed uniformly by containing an adsorbent. Owing to this, the production efficiency, product stability and product properties of the patch 1 are enhanced.
Thus, the pressure-sensitive adhesive layer 3 contains an adsorbent, and examples of the applicable adsorbent include the inorganic substances and organic substances described as having hygroscopic properties, dampproofing properties, adsorptive properties among the additives listed in “Japanese Pharmaceutical Excipients Directory 2000, published on Apr. 28, 2000, 1st edition” and aminoalkyl methacrylate copolymers and zinc oxide, which are not described in the above “Japanese Pharmaceutical Excipients Directory 2000” but have been known to have adsorptive properties. Among these, preferable examples include minerals such as talc, kaoline, and bentonite; silicone compounds such as fumed silica (Aerosil (registered trademark), etc.) and hydrous silica; metal compounds such as zinc oxide and dried aluminum hydroxide gel; weak acids such as lactic acid and acetic acid, sugars such as dextrin, and high molecular weight polymers such as polyvinylpyrrolidone, propylene glycol, aminoalkyl methacrylate copolymers, crospovidone, and carboxy vinyl polymers. These adsorbents may be used in combination of two or more as necessary.
The content of the adsorbent in the pressure-sensitive adhesive layer 3 is preferably 0.5 to 50% by mass on the total mass basis of the pressure-sensitive adhesive layer 3. A content of 0.5% by mass or lower tends not to achieve sufficient effects to control the aggregation and growth of the metal salt crystal or to disperse the crystal uniformly. Conversely, a content of 50% by mass or higher has a tendency of reducing the adhesion of the pressure-sensitive adhesive layer 3, likely making it difficult to apply the patch.
The patch 1 of the present invention may contain as necessary, in addition to the above compositions, tackifier, plasticizer, absorption enhancer, antioxidant, filler, crosslinking agent, preservative and ultraviolet absorber.
Examples of the usable tackifier include rosin resins such as “Ester Gum (tradename, Arakawa Chemical Industries, Ltd.)”, “Hariester (tradename, Harima Chemicals, Inc.)”, “Pentalyn (tradename, Eastman Chemical Company)”, “Foral (tradename, Eastman Chemical Company)”, terpene resins such as “YS resin (tradename, Yasuhara Chemical Co., Ltd.)”, “Piccolyte (tradename, Loos and Dilworth)”, petroleum resins such as “Arkon (tradename, Arakawa Chemical Industries, Ltd.)”, “Regalrez (tradename, Eastman Chemical Company)”, “Piccolastic (tradename, Eastman Chemical Company)”, “Escorez (tradename, ExxonMobil Chemical Company)”, “Wingtack (tradename, Goodyear)”, “Quinton (tradename, Zeon Corporation)”, phenol resins, and xylene resins.
These tackifiers may be used singly or in combination of two or more. The amount of the tackifier to be added is preferably 10 to 90% by mass, more preferably 15 to 70% by mass, particularly preferably 20 to 60% by mass, on the basis of the total mass of the pressure-sensitive adhesive layer 3, when considering the sufficient adhesion of and the local irritation when removing the patch 1.
Examples of the plasticizer include petroleum oils such as paraffin process oils, naphthene process oils, and aromatic process oils; squalane, squalene; plant oils such as olive oil, camellia oil, castor oil, tall oil, and peanut oil; dibasic esters such as dibutyl phthalate, and dioctyl phthalate; liquid rubbers such as polybutene and liquid isoprene rubber; and diethylene glycol, polyethylene glycol, propylene glycol, and dipropylene glycol. These plasticizers can be used singly or two Or more can be used in combination.
In the embodiment of the present invention, the liquid paraffin and liquid polybutene are preferably used.
The content of the above plasticizer in the pressure-sensitive adhesive layer 3 is preferably 1 to 60% by mass, more preferably 2 to 50% by mass, particularly preferably 3 to 40% by mass, on the basis of the total mass of the pressure-sensitive adhesive layer 3, considering the maintenance of the sufficient adhesion of the patch 1.
Examples of the preferably used absorption enhancer include fatty alcohols such as isostearyl alcohol, fatty acids such as capric acid, fatty acid derivatives such as propyleneglycol monolaurate and isopropyl myristate, propylene glycol, polyethylene glycol, and lauric acid diethanolamine. These absorption enhancers may be used singly, or in combination of two or more. The content of the absorption enhancer is preferably 1 to 30% by mass, more preferably 3 to 20% by mass, particularly preferably 5 to 15% by mass, on the basis of the total mass of the patch 1, considering the sufficient permeability of the active ingredients to the tissue, the local irritation, and the like, as a patch.
Examples of the usable antioxidant include tocopherols and ester derivatives thereof, ascorbic acid, ascorbyl stearate, nordihydroguaiaretic acid, dibutylhydroxytoluene (hereinafter abbreviated as BHT), and butylated hydroxyanisole, with BHT being particularly preferably used.
Examples of the filler include aluminum hydroxide, calcium carbonate, magnesium carbonate; silicates such as aluminum silicate and magnesium silicate; silicic acid, barium sulfate, calcium sulfate, calcium zincate, zinc oxide, titanium oxide, and the like.
Examples of the crosslinking agent include thermosetting resins such as amino resin, phenol resin, epoxy resin, alkyd resin, and unsaturated polyester, isocyanate compounds, blocked isocyanate compounds, organic crosslinking agents as well as inorganic crosslinking agents such as metals and metal compounds.
Examples of the preservative preferably usable include disodium edetate, tetrasodium edetate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and butyl parahydroxybenzoate.
Examples of the ultraviolet absorber include p-aminobenzoic acid derivatives, anthranilic acid derivatives, salicylic acid derivatives, coumarin derivatives, amino acid compounds, imidazoline derivatives, pyrimidine derivatives, and dioxane derivatives.
The above mentioned antioxidants, fillers, crosslinking agents, preservatives and ultraviolet absorbers can be added in a total amount of preferably 5% by mass or less, more preferably 3% by mass or less, particularly preferably 1% by mass or less, on the basis of the total mass of the pressure-sensitive adhesive layer 3.
Next, an embodiment of the production process of the patch 1 will be described.
First, a mixture for forming a pressure-sensitive adhesive layer 3 is prepared. Using a mixer, the above mentioned pressure-sensitive adhesive base, an acid addition salt of a drug, neutralizer, adsorbent and other ingredients are dissolved or dispersed in a solvent of the pressure-sensitive adhesive base to obtain a mixture for forming the pressure-sensitive adhesive layer 3.
Examples of the usable solvent for the pressure-sensitive adhesive base include toluene, hexane, ethyl acetate, cyclohexane, heptane, butyl acetate, ethanol, methanol, xylene, and isopropanol. These are selected as necessary in accordance with the ingredients to be dissolved or dispersed, and may be used singly or in combination of two or more.
Subsequently, the obtained mixture for forming the pressure-sensitive adhesive layer 3 is spread directly on a backing layer 2 to form the pressure-sensitive adhesive layer 3, or the mixture is spread on a release-treated paper or film to form the pressure-sensitive adhesive layer 3 and the backing layer 2 is placed thereon, followed by the press-bonding transfer of the pressure-sensitive adhesive layer 3 to the backing layer 2. Next, a release sheet 4 for protecting the pressure-sensitive adhesive layer 3 is adhered on the pressure-sensitive adhesive layer 3 to obtain the patch 1.

EXAMPLES

Hereinafter, the present invention will be specifically described with reference to Examples, but is not limited thereto.

Example 1

Using a mixer, ropinirole hydrochloride, sodium hydroxide, Aerosil (registered trademark), liquid paraffin and toluene (solvent) were mixed in advance, and a separately prepared mixed solution of SIS (JSR Corporation, SIS5000), a terpene resin (YS resin) and toluene was added thereto and mixed to obtain a pressure-sensitive adhesive solution. The solution was spread on a release-treated film to dry and remove the solvent, thereby forming a pressure-sensitive adhesive layer. A backing layer was placed on the layer and the pressure-sensitive adhesive layer was subjected to press-bonding transfer to obtain a patch.
The content of the ingredients other than the solvent was ropinirole hydrochloride 15 parts by mass, sodium hydroxide 4 parts by mass (2.0 times equivalent to ropinirole hydrochloride), Aerosil (registered trademark) 5 parts by mass, liquid paraffin 24.1 parts by mass, SIS 20.1 parts by mass, and the terpene resin (YS resin) 31.8 parts by mass.

Examples 2 to 8

Patches of Examples 2 to 8 were produced respectively in the same manner as in Example 1 except that aminoalkyl methacrylate copolymer, crospovidone, lactic acid, talc, dextrin, propylene glycol or polyvinylpyrrolidone was used in place of Aerosil (registered trademark) as an adsorbent in the same parts by mass (Table 1).

Comparative Example 1

A patch of Comparative Example 1 was produced in the same manner as in Example 1 except that an adsorbent was not contained (Table 1). The mixing ratio of ropinirole hydrochloride, sodium hydroxide, liquid paraffin, SIS and the terpene resin (YS resin) was the same as in Example 1.

Comparative Examples 2 to 20

Patches of Comparative Examples 2 to 21 were produced respectively in the same manner as in Example 1 except that isostearic acid, oleic acid, sorbitan monolaurate, sorbitan monooleate, isopropyl myristate, isopropyl palmitate, hexyl laurate, glycerol monooleate, triacetin, lauryl alcohol, myristyl alcohol, oleyl alcohol, polybutene, propylene glycol monolaurate, Tween 80 (registered trademark), lauric acid diethanolamide, isostearyl alcohol, octyldodecanol or benzyl alcohol was used in place of Aerosil (registered trademark) as an absorbent in the same parts by mass (Table 1).

Example 9

After mixing terbinafine hydrochloride, sodium hydroxide, Aerosil (registered trademark), isopropyl myristate and ethyl acetate (solvent) in advance using a mixer, an acrylic pressure-sensitive adhesive (National Starch and Chemical Company, Duro-TAK87-2516, solid content: 41.5%) was added to and mixed with the mixture to obtain a pressure-sensitive adhesive solution. The solution was spread on a release-treated film to dry and remove the solvent, thereby forming a pressure-sensitive adhesive layer. A backing layer was placed on the layer and the pressure-sensitive adhesive layer was subjected to press-bonding transfer to obtain a patch.
The content of the ingredients other than the solvent was terbinafine hydrochloride 10 parts by mass, sodium hydroxide 2.4 parts by mass (2.0 times equivalent to terbinafine hydrochloride), Aerosil (registered trademark) 5 parts by mass, isopropyl myristate 10 parts by mass and acrylic pressure-sensitive adhesive base in the acrylic pressure-sensitive adhesive 72.6 parts by mass.

Examples 10 to 22

Patches of Examples 10 to 22 were produced respectively in the same manner as in Example 9 except that aminoalkyl methacrylate copolymer, crospovidone, zinc oxide, bentonite, kaoline, polyvinylpyrrolidone, talc, hydrous silica or dried aluminum hydroxide gel was used in place of Aerosil (registered trademark) as an adsorbent in the same parts by mass (Table 2).

Comparative Example 21

A patch of Comparative Example 21 was produced in the same manner as in Example 9 except that an adsorbent was not contained (Table 2). The mixing ratio of terbinafine hydrochloride, sodium hydroxide, Aerosil (registered trademark), isopropyl myristate and the acrylic pressure-sensitive adhesive base was the same as in Example 9.

Example 23

After mixing varenicline tartrate, sodium hydroxide, crospovidone and methanol (solvent) in advance using a mixer, an acrylic pressure-sensitive adhesive material (National Starch and Chemical Company, Duro-TAK87-2516, solid content: 41.5%) was added to and mixed with the mixture to obtain a pressure-sensitive adhesive solution. The solution was spread on a release-treated film to dry and remove the solvent, thereby forming a pressure-sensitive adhesive layer. A backing layer was placed thereon and the pressure-sensitive adhesive layer was subjected to press-bonding transfer to obtain a patch.
The content of the ingredients other than the solvent was varenicline tartrate 10 parts by mass, sodium hydroxide 2.2 parts by mass (2.0 times equivalent to terbinafine hydrochloride), crospovidone 3 parts by mass and acrylic pressure-sensitive adhesive base in the acrylic pressure-sensitive adhesive 84.8 parts by mass.

Examples 24 and 25

Patches of Examples 24 and 25 were produced respectively in the same manner as in Example 23 except that aminoalkyl methacrylate copolymer or polyvinylpyrrolidone was used in place of crospovidone as an adsorbent (Table 3).

Comparative Example 22

A patch of Comparative Example 22 was produced in the same manner as in Example 23 except that an adsorbent was not contained (Table 3). The mixing ratio of varenicline tartrate and sodium hydroxide was made same as in Example 23, with the acrylic pressure-sensitive adhesive base being 87.8 parts by mass.
Patch Evaluation
The appearances of the patches immediately after production were examined and evaluated for the presence of aggregates of the metal salt crystal with naked eyes. Tables 1 to 3 show the adsorbents, content thereof and the evaluation results. The patches wherein no aggregates were found are indicated as “a”, those wherein small aggregates of an average particle size of 100 to 250 μm were found but practically having no problem are indicated as “b”, and those wherein many large aggregates of an average particle size of exceeding 250 μm are indicated as “c”.

TABLE 1

	Content
	[parts
Adsorbent	by mass]	Result

Example 1	Aerosil	5	a
	(registered trademark)
Example 2	Aminoalkyl methacrylate	5	a
	copolymer
Example 3	Crospovidone	5	a
Example 4	Lactic acid	5	a
Example 5	Talc	5	a
Example 6	Dextrin	5	b
Example 7	Propylene glycol	5	b
Example 8	Polyvinylpyrrolidone	5	b
Comparative Example 1	None	0	c
Comparative Example 2	Isostearic acid	5	c
Comparative Example 3	Oleic acid	5	c
Comparative Example 4	Sorbitan monolaurate	5	c
Comparative Example 5	Sorbitan monooleate	5	c
Comparative Example 6	Isopropyl myristate	5	c
Comparative Example 7	Isopropyl palmitate	5	c
Comparative Example 8	Hexyl laurate	5	c
Comparative Example 9	Glycerol monooleate	5	c
Comparative Example 10	Triacetin	5	c
Comparative Example 11	Lauryl alcohol	5	c
Comparative Example 12	myristyl alcohol	5	c
Comparative Example 13	Oleyl alcohol	5	c
Comparative Example 14	Polybutene	5	c
Comparative Example 15	Propylene glycol	5	c
	monolaurate
Comparative Example 16	Tween 80	5	c
	(registered trademark)
Comparative Example 17	Lauric acid	5	c
	diethanolamide
Comparative Example 18	Isostearyl alcohol	5	c
Comparative Example 19	Octyldodecanol	5	c
Comparative Example 20	Benzyl alcohol	5	c

TABLE 2

	Content
	[parts
Adsorbent	by mass]	Result

Example 9	Aerosil	5	a
	(registered trademark)
Example 10	Aminoacryl methacrylate	10	a
	copolymer
Example 11	Aminoacryl methacrylate	15	a
	copolymer
Example 12	Crospovidone	10	a
Example 13	Crospovidone	15	a
Example 14	Zinc oxide	3	a
Example 15	Zinc oxide	5	a
Example 16	Zinc oxide	7	a
Example 17	Bentonite	5	b
Example 18	Kaoline	5	b
Example 19	Polyvinylpyrrolidone	5	b
Example 20	Talc	5	b
Example 21	Hydrous silica	5	b
Example 22	Dried aluminum	5	b
	hydroxide gel
Comparative Example 21	None	0	c

TABLE 3

	Content
	[parts
Adsorbent	by mass]	Result

Example 23	Crospovidone	3	a
Example 24	Aminoacryl	3	a
	methacrylate
	copolymer
Example 25	Polyvinyl-	3	b
	pyrrolidone
Comparative Example 22	None	0	c

INDUSTRIAL APPLICABILITY

Claims

1. A patch comprising: a drug, a metal salt, an adsorbent, and a pressure-sensitive adhesive base, wherein

the metal salt is a salt comprising a substance capable of forming a drug salt by bonding to the drug or a component thereof;

a content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed; and

the adsorbent is an adsorbent that adsorbs a polar solvent comprised in the patch.

2. The patch according to claim 1, wherein the metal salt is formed in the patch during production or after production.

3. The patch according to claim 1, wherein the drug is a basic drug.

4. The patch according to claim 1, wherein the metal salt is at least one metal salt selected from the group consisting of metal chlorides, metal bromides, metal iodides and organic acid metal salts.

5. The patch according to claim 1, wherein the metal salt is at least one metal salt selected from the group consisting of sodium chloride, calcium chloride, aluminum chloride, stannous chloride, ferric chloride, magnesium chloride, potassium chloride, sodium citrate, sodium oxalate, sodium tartrate, sodium bromide, and sodium succinate.

6. The patch according to claim 1, wherein the adsorbent is at least one adsorbent selected from the group consisting of talc, kaoline, bentonite, hydrous silica, fumed silica, polyvinylpyrrolidone, propylene glycol, aminoalkyl methacrylate copolymer, crospovidone, carboxy vinyl polymer, lactic acid, acetic acid, zinc oxide, dextrin, and dried aluminum hydroxide gel.

7. The patch according to claim 3, wherein the basic drug is a drug formed from a basic drug acid addition salt.

8. The patch according to claim 7, wherein the basic drug acid addition salt is hydrochloride, acetate, sulfate, maleate, oxalate, citrate, hydroiodide, hydrobromate, mesylate, tartrate or succinate of a basic drug.

9. A patch comprising a backing layer and a pressure-sensitive adhesive layer provided on the backing layer and comprising the patch according to claim 1.

10. A method of suppressing an aggregation and growth of a metal salt present in a pressure-sensitive adhesive layer of a patch, comprising:

providing a patch comprising a drug, the metal salt, an adsorbent and a pressure-sensitive adhesive base,

wherein the metal salt is a salt comprising a substance capable of forming a drug salt by bonding to the drug or a component thereof,

wherein a content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed, and