US20110106117A1 - Device and Method for Modifying the Shape of a Body Organ - Google Patents
Device and Method for Modifying the Shape of a Body Organ Download PDFInfo
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- US20110106117A1 US20110106117A1 US13/004,239 US201113004239A US2011106117A1 US 20110106117 A1 US20110106117 A1 US 20110106117A1 US 201113004239 A US201113004239 A US 201113004239A US 2011106117 A1 US2011106117 A1 US 2011106117A1
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- focal
- lumen
- deflector
- connector
- target tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2451—Inserts in the coronary sinus for correcting the valve shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
Definitions
- the mitral valve is a portion of the heart that is located between the chambers of the left atrium and the left ventricle. When the left ventricle contracts to pump blood throughout the body, the mitral valve closes to prevent the blood from being pumped back into the left atrium. In some patients, whether due to genetic malformation, disease or injury, the mitral valve fails to close properly causing a condition known as regurgitation, whereby blood is pumped into the atrium upon each contraction of the heart muscle. Regurgitation is a serious, often rapidly deteriorating, condition that reduces circulatory efficiency and must be corrected.
- Two of the more common techniques for restoring the function of a damaged mitral valve are to surgically repair the valve, replace the valve with a mechanical valve, or to suture a flexible ring around the valve to support it.
- Each of these procedures is highly invasive because access to the heart is obtained through an opening in the patient's chest. Patients with mitral valve regurgitation are often relatively frail thereby increasing the risks associated with such an operation.
- a support device in a lumen such as a vein or artery
- a reshaping should be limited to the target tissue, such as the mitral valve annulus, and any reshaping of other tissue adjacent to the lumen should be minimized or avoided.
- the device is placed in the coronary sinus to reshape the mitral valve annulus. Care should be taken to minimize the reshaping of other adjacent tissue, such as nearby arteries. See, e.g., the following applications (the disclosures of which are incorporated herein by reference): U.S. patent application Ser. No.
- One aspect of the invention is a tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen.
- the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen.
- the focal deflector may have an expandable portion that is, e.g., self-expanding or expandable through the application of an actuation force.
- the device may also have a lock to lock the focal deflector in an expanded configuration.
- the focal deflector is integral with the connector.
- the focal deflector may be a bend in the connector, such as a bend that extends away from the lumen axis and toward the target tissue.
- the focal deflector may include a local change to the linear shape of the connector, such as a portion of increased curve of the curved line of the connector.
- the focal deflector may also include a flattened portion of the connector.
- the focal deflector includes an expandable anchor and possibly a portion integral with the connector and adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
- Another aspect of the invention is a method of modifying target tissue shape.
- the method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
- the expanding step includes the steps of expanding the distal anchor to anchor within the lumen; applying a proximally directed force on the device; and expanding the proximal anchor while applying the proximally directed force.
- the placing step includes the step of orienting the focal deflector away from the lumen axis and toward the target tissue. In other embodiments, the placing step includes the step of orienting the focal deflector away from the lumen axis and away from the target tissue.
- the applying step may include the step of expanding the focal deflector, such as by applying an actuation force to the focal deflector.
- the focal deflector may also be locked in its expanded configuration.
- the applying and expanding steps may include expanding the distal anchor to anchor within the lumen; applying a proximally directed force on the device; expanding the focal deflector while applying the proximally directed force; applying a proximally directed force on the device after expanding the focal deflector; and expanding the proximal anchor while applying the proximally directed force of the previous step.
- Yet another aspect of the invention is a tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen.
- the device includes an expandable anchor; a focal deflector; a connector disposed between the anchor and the focal deflector; and a tail extending from the focal deflector away from the anchor.
- the focal deflector may include an expandable portion.
- the focal deflector is adapted to extend away from the lumen axis and away from the target tissue when the device is deployed in the lumen.
- FIG. 1 shows a tissue reshaping device according to one aspect of the invention deployed in a coronary sinus to reshape the mitral valve annulus to treat mitral valve regurgitation.
- FIG. 2 is a perspective view of the device shown in FIG. 1 .
- FIG. 3 shows another embodiment of the invention.
- FIG. 4 shows another embodiment of the invention and its use to treat mitral valve regurgitation.
- FIG. 5 is a perspective view of the device shown in FIG. 4 .
- FIG. 6 shows an embodiment in which the focal deflector faces in the same direction as the anchors.
- FIG. 7 shows yet another embodiment of the invention deployed in a coronary sinus to reshape the mitral valve annulus to treat mitral valve regurgitation.
- FIG. 8 is a perspective view of the device shown in FIG. 7 .
- FIG. 9 shows yet another embodiment of the invention.
- FIG. 10 shows still another embodiment of the invention.
- FIG. 11 shows the focal deflector of the embodiment of FIG. 10 .
- FIG. 12 is yet another view of the focal deflector of the embodiment of FIG. 10 .
- FIG. 13 shows yet another embodiment of the invention.
- FIG. 14 shows an embodiment of the invention with a tail portion extending from the focal deflector.
- FIG. 15 illustrates one method for delivering an intravascular support to a desired location in the body.
- Tissue shaping devices that apply force to a localized, discrete portion of the vessel wall surrounding a lumen have been described. See, e.g., U.S. patent application Ser. No. 10/003,910, “Focused Compression Mitral Valve Device and Method,” which describes the use of such devices disposed in the coronary sinus to treat mitral valve regurgitation.
- Other therapies deploy one or more rigid devices in the lumen to change the shape of the lumen and adjacent tissue. See, e.g., Lashinski et al. U.S. patent application Ser. No. 10/066,302 (published as U.S. 2002/0151961 A1); Taylor et al. U.S. patent application Ser. No. 10/068,264 (published as U.S.
- tissue shaping devices utilize an “anchor and cinch” method to modify tissue adjacent a lumen, i.e., by anchoring a distal anchor, placing a proximally-directed force on a connector extending proximally from the distal anchor, and anchoring a proximal anchor before ceasing the proximally directed force to maintain the device's configuration and the reshaping of the tissue.
- the present invention provides a device disposed in a lumen to reshape tissue adjacent to the lumen that includes a focal deflector tissue reshaper, two anchors and an optional connector to help maintain the position of the focal tissue reshaper within the lumen.
- a focal deflector tissue reshaper aimed at target tissue adjacent to the lumen minimizes the risk of adverse consequences from altering the shape of non-target tissue adjacent to other parts of the lumen.
- the anchors and/or connector may also be used to help reshape the target tissue.
- FIGS. 1 and 2 show a tissue reshaping device 10 according to one aspect of this invention.
- Device 10 is designed to be disposed in the coronary sinus or other cardiac vein to treat mitral valve regurgitation. It should be understood that such devices may also be used in other body lumens to reshape other tissue.
- device 10 has a proximal anchor 12 and a distal anchor 14 connected by a connector 15 .
- the anchors 12 and 14 are formed from metal wire, preferably made from a shape memory material such as nitinol, bent into a FIG. 8 configuration.
- Crimps 16 and 18 hold the wire in place and attach the anchors to connector 15 .
- crimps 16 and 18 are formed from wound wire, such as nitinol.
- crimps 16 and 18 are formed from metal tubes, such as titanium tubes.
- Device 10 is delivered via a catheter to the treatment site within the lumen in a collapsed or unexpanded configuration. After expelling device 10 from the catheter at the treatment site (either by advancing the device distally out of the end of the catheter or by moving the end of the catheter proximally while maintaining the device stationary), the device's anchors begin to self-expand. At the proximal end of each anchor is an eyelet 20 and 22 . Advancing eyelets 20 and 22 distally over corresponding lock bumps 24 and 26 further expands and locks the anchors 12 and 14 in an expanded configuration. Further details of the construction, delivery and deployment of such anchors may be found in U.S.
- Device 10 has a focal deflector 28 facing away from the anchors 12 and 14 and toward the mitral valve annulus.
- focal deflector 28 is formed as a bend in the connector 15 .
- FIG. 1 when disposed in lumen 30 (shown here as the coronary sinus), the orientation of device 10 places focal deflector 28 against the target tissue 37 to reshape the mitral valve annulus 38 .
- Device 10 may be curved to help ensure this orientation.
- focal deflector 28 is deformed and assumes the shape shown in FIGS. 1 and 2 after deployment from the catheter.
- the desired reshaping of the mitral valve annulus may be achieved with less cinching than other device designs or even with no cinching.
- the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors.
- any undesirable effect on non-target tissue adjacent the connector is also minimized.
- reshaping adjacent to the anchors and/or connector be desired, such reshaping can be achieved through a combination of expansion of the anchors and cinching of the connector between them.
- the cinching is performed as with prior devices: by anchoring a distal anchor, placing a proximally-directed force on a connector extending proximally from the distal anchor, and anchoring a proximal anchor before ceasing the proximally directed force to maintain the device's configuration and the reshaping of the tissue.
- FIG. 3 shows another embodiment of the invention.
- device 40 in FIG. 3 has two anchors 42 and 44 connected by a connector 46 .
- Connector 46 is formed as a ribbon, preferably from a shape memory material such as nitinol, with a focal deflector 48 formed therein.
- the anchors 42 and 44 may be formed like the anchors of the previous embodiment.
- device 40 is delivered via catheter to the treatment site in a collapsed or unexpanded configuration.
- Device 40 is then deployed by expelling it from the catheter and expanding it within a lumen in a position and orientation that places focal deflector 48 against the lumen's vessel wall adjacent to the target tissue to modify the shape of the target tissue. While the device may also be cinched to provide additional reshaping, the amount of cinching required will be less, thereby minimizing the reshaping of any non-target tissue adjacent the lumen by the connector.
- anchors 42 and 44 do not need to be expanded as much, thereby minimizing the reshaping of the non-target tissue adjacent to the anchors.
- FIGS. 4 and 5 show yet another embodiment of the invention and its use to treat mitral valve regurgitation.
- Device 50 has proximal and distal anchors 52 and 54 connected by a connector 56 .
- Anchors 52 and 54 are preferably formed like the anchors of the embodiments of FIGS. 1-3 .
- a focal deflector 58 is disposed on connector 56 .
- focal deflector 58 has substantially the same design as anchors 52 and 54 .
- Focal deflector 58 is formed from wire (preferably made from a shape memory material such as nitinol) and has a FIG. 8 configuration when expanded.
- a crimp 62 attaches the wire to the connector 56 .
- the anchors and focal deflector are delivered via a catheter to the appropriate site within the lumen in an unexpanded configuration, then expanded to a deployed configuration through the application of actuation forces delivered by catheters or other known tools.
- focal deflector 58 may be locked in its expanded configuration by advancing an eyelet 60 over a lock bump 61 .
- the orientation of device 50 when disposed in a lumen such as the coronary sinus, the orientation of device 50 places focal deflector 58 against the coronary sinus wall adjacent the target tissue 59 of the mitral valve annulus 57 to reshape the mitral valve annulus.
- Device 50 may be curved to help ensure proper orientation.
- focal deflector 58 because of the action of focal deflector 58 , the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching.
- the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors.
- the effect on non-target tissue adjacent the connector is also minimized.
- the focal deflector 58 of FIGS. 4 and 5 can also be used like an anchor during a cinching operation.
- a proximally-directed force can be exerted on the portion of connector 56 extending between distal anchor 54 and focal deflector 58 prior to expanding and locking focal deflector 58 to cinch the distal portion of device 50 .
- another proximally-directed force can be exerted on the portion of connector 56 extending between focal deflector 58 and proximal anchor 52 prior to expanding and locking proximal anchor 52 to cinch the proximal portion of device 50 .
- the presence of focal deflector 58 enables a user to cinch the distal and proximal portions of device 50 with different cinching forces.
- FIG. 6 shows an embodiment in which the focal deflector 68 of device 60 faces in the same direction as the anchors 62 and 64 .
- the focal deflector of the embodiments of FIGS. 4-6 may be self-expanding but not locking.
- FIGS. 7 and 8 show yet another embodiment of the invention.
- device 70 has a proximal anchor 72 and a distal anchor 74 connected by a connector 76 .
- a focal deflector 78 Disposed on connector 76 is a focal deflector 78 formed as an expanded cut-out tube, such as a modified stent.
- device 70 may be deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent to focal deflector 78 .
- Device 70 is delivered to in an expanded configuration to the treatment site, then expelled from the catheter.
- Anchors 72 and 74 self-expand, then are further expanded and locked as in the other embodiments.
- Focal deflector 78 may also self-expand to the configuration shown in FIGS. 7 and 8 .
- focal deflector 78 may be expanded by using a balloon catheter to provide the actuation force, as is well-known in the stent art.
- the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching.
- the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors.
- the effect on non-target tissue adjacent the connector is also minimized.
- FIG. 9 shows an embodiment of a device 80 with proximal and distal anchors 82 and 84 with a FIG. 8 design like other embodiments connected by a connector 86 .
- a focal deflector 88 is formed as a flattened area in connector 86 .
- connector 86 and focal deflector 88 are formed from shape memory material wire, such as nitinol. While FIG. 9 shows connector 86 and focal deflector 88 as three discrete straight segments, any or all of these elements may be have a curve. In any variation on the embodiment of FIG. 9 , however, the focal deflector 88 is straighter than the connector portions extending distally and proximally from it to the distal and proximal anchors, respectively.
- Device 80 may be delivered and deployed at the treatment site in the same manner as the embodiments described above.
- FIGS. 10-12 show yet another embodiment of a device 90 with proximal and distal anchors 92 and 94 with a FIG. 8 design like other embodiments connected by a connector 96 .
- a focal deflector 98 is also formed with a wire 100 (preferably made from a shape memory material such as nitinol) bent into a FIG. 8 pattern.
- a wire 100 preferably made from a shape memory material such as nitinol
- focal deflector 98 instead of a wrapped wire or solid metal crimp, focal deflector 98 has a base 102 with two downwardly extending struts 104 . The angular spread between struts 104 helps orient the device within the lumen.
- Base 102 may be made from a laser-cut shape memory material such as nitinol.
- device 90 may be delivered via a catheter and deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent to focal deflector 98 .
- the device is in a deformed and unexpanded state within the catheter, and self-expands and reforms into the shape shown in FIG. 10 once expelled from the catheter.
- the anchors 92 and 94 and the anchor portion 100 of focal deflector 98 are further expanded and locked by advancing their respective eyelets over corresponding lock bumps on their proximal sides.
- focal deflector 98 Because of the action of focal deflector 98 , the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching. Thus, the anchors 92 and 94 do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors. In addition, with less or no cinching, the effect on non-target tissue adjacent the connector is also minimized. Furthermore, because focal deflector 98 is formed similar to an anchor, the presence of focal deflector 98 enables a user to cinch the distal and proximal portions of device 90 with different cinching forces.
- FIG. 13 omits the wire 100 of focal deflector 98 but is identical to the embodiment of FIGS. 10-12 in all other respects.
- FIG. 14 shows an embodiment of a device 110 with a proximal anchor 112 formed in a FIG. 8 pattern, as in other embodiments.
- a focal deflector 114 formed as an anchor in a FIG. 8 pattern, as in the embodiment of FIG. 6 is connected to proximal anchor 112 by a connector 116 .
- a tail 118 extends distally from focal deflector 114 formed from a wire bent in a loop.
- the loop has a circumference that allows the loop to engage the wall of the vessel in which the device is placed.
- the points of engagement between the loop and vessel depend on the relative diameters of the loop and vessel.
- When deployed in a curved vessel, such as the coronary sinus, the loop will follow the vessel's curve to orient the device correctly within the vessel.
- the ends of the wire are contained with a crimp 120 .
- a small loop 122 is formed at the distal end of tail 118 to provide additional spring action to the tail.
- device 110 may be delivered via a catheter and deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent to focal deflector 114 .
- the device is in a deformed and unexpanded state within the catheter, and self-expands and reforms into the shape shown in FIG. 14 once expelled from the catheter.
- the proximal anchor 112 and focal deflector 114 are further expanded and locked by advancing their respective eyelets over corresponding lock bumps on their proximal sides.
- Element 114 of device 110 in FIG. 14 may be used as a distal anchor instead of as a focal deflector, of course.
- FIG. 15 illustrates one method for delivering an intravascular support 150 in accordance with the present invention to a desired location in the body.
- intravascular support 150 is preferably loaded into and routed to a desired location within a catheter 200 with the proximal and distal anchors in a collapsed or deformed condition. That is, the eyelet 172 of the distal anchor 170 is positioned proximally of the distal lock 160 and the eyelet 142 of the proximal anchor is positioned proximal to the proximal lock 164 .
- the physician ejects the distal end of the intravascular support from the catheter 200 into the lumen by advancing the intravascular support or retracting the catheter or a combination thereof.
- a pusher (not shown) provides distal movement of the intravascular support with respect to catheter 200
- a tether provides proximal movement of the intravascular support with respect to catheter 200 .
- the distal anchor begins to expand as soon as it is outside the catheter. Once the intravascular support is properly positioned, the eyelet 172 of the distal anchor is pushed distally over the distal lock 160 so that the distal anchor 170 further expands and locks in place to securely engage the lumen wall and remains in the expanded condition.
- the proximal end of the support wire is tensioned by applying a proximally-directed force on the support wire and distal anchor to apply sufficient pressure on the tissue adjacent the support wire to modify the shape of that tissue.
- a proximally-directed force on the support wire and distal anchor may be used to see when the support wire supplies sufficient pressure on the mitral valve to aid in its complete closure with each ventricular contraction without otherwise adversely affecting the patient.
- the eyelet 142 of the proximal anchor is advanced distally over the proximal lock 164 to expand and lock the proximal anchor, thereby securely engaging the lumen wall and maintaining the pressure of the support wire against the lumen wall.
- the mechanism for securing the proximal end of the intravascular support can be released.
- the securement is made with a braided loop 202 at the end of the tether and a hitch pin 204 .
- the hitch pin 204 is withdrawn thereby releasing the loop 202 so it can be pulled through the proximal lock 164 at the proximal end of the intravascular support 150 .
- the anchors may be of some other design known in the art.
- the focal deflector may have some other shape designed to make the desired change in the target tissue.
Abstract
A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
Description
- This application is a divisional of U.S. application Ser. No. 10/840,188, filed May 5, 2004, which application claims the benefit of U.S. Provisional Application No. 60/476,693, filed Jun. 5, 2003; both of which are incorporated herein by reference.
- The mitral valve is a portion of the heart that is located between the chambers of the left atrium and the left ventricle. When the left ventricle contracts to pump blood throughout the body, the mitral valve closes to prevent the blood from being pumped back into the left atrium. In some patients, whether due to genetic malformation, disease or injury, the mitral valve fails to close properly causing a condition known as regurgitation, whereby blood is pumped into the atrium upon each contraction of the heart muscle. Regurgitation is a serious, often rapidly deteriorating, condition that reduces circulatory efficiency and must be corrected.
- Two of the more common techniques for restoring the function of a damaged mitral valve are to surgically repair the valve, replace the valve with a mechanical valve, or to suture a flexible ring around the valve to support it. Each of these procedures is highly invasive because access to the heart is obtained through an opening in the patient's chest. Patients with mitral valve regurgitation are often relatively frail thereby increasing the risks associated with such an operation.
- One less invasive approach for aiding the closure of the mitral valve involves the placement of a support structure in the cardiac sinus and vessel that passes adjacent the mitral valve. The support structure is designed to push the vessel and surrounding tissue against the valve to aid its closure. This technique has the advantage over other methods of mitral valve repair because it can be performed percutaneously without opening the chest wall. Examples of such devices are shown in U.S. patent application Ser. No. 10/003,910, “Focused Compression Mitral Valve Device and Method;” U.S. patent application Ser. No. 10/142,637, “Body Lumen Device Anchor, Device and Assembly;” U.S. patent application Ser. No. 10/331,143, “System and Method to Effect the Mitral Valve Annulus of a Heart;” and U.S. patent application Ser. No. 10/429,172, “Device and Method for Modifying the Shape of a Body Organ,” filed May 2, 2003. The disclosures of these patent applications are incorporated herein by reference.
- The purpose of a support device in a lumen such as a vein or artery is to reshape a particular tissue area adjacent to the lumen. In order to be minimally invasive, the reshaping should be limited to the target tissue, such as the mitral valve annulus, and any reshaping of other tissue adjacent to the lumen should be minimized or avoided. For example, to treat mitral valve regurgitation, the device is placed in the coronary sinus to reshape the mitral valve annulus. Care should be taken to minimize the reshaping of other adjacent tissue, such as nearby arteries. See, e.g., the following applications (the disclosures of which are incorporated herein by reference): U.S. patent application Ser. No. 09/855,945, “Mitral Valve Therapy Device, System and Method” (published Nov. 14, 2002, as U.S. 2002/0169504 A1); U.S. patent application Ser. No. 09/855,946, “Mitral Valve Therapy Assembly and Method” (published Nov. 14, 2002, as U.S. 2002/0169502 A1). It is also advisable to monitor cardiac perfusion during and after such mitral valve regurgitation therapy. See, e.g., U.S. patent application Ser. No. 10/366,585, “Method of Implanting a Mitral Valve Therapy Device,” the disclosure of which is incorporated herein by reference.
- One aspect of the invention is a tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The focal deflector may have an expandable portion that is, e.g., self-expanding or expandable through the application of an actuation force. The device may also have a lock to lock the focal deflector in an expanded configuration.
- In some embodiments the focal deflector is integral with the connector. For example, the focal deflector may be a bend in the connector, such as a bend that extends away from the lumen axis and toward the target tissue. The focal deflector may include a local change to the linear shape of the connector, such as a portion of increased curve of the curved line of the connector. The focal deflector may also include a flattened portion of the connector.
- In some embodiments the focal deflector includes an expandable anchor and possibly a portion integral with the connector and adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
- Another aspect of the invention is a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen. In some embodiments the expanding step includes the steps of expanding the distal anchor to anchor within the lumen; applying a proximally directed force on the device; and expanding the proximal anchor while applying the proximally directed force.
- In some embodiments, the placing step includes the step of orienting the focal deflector away from the lumen axis and toward the target tissue. In other embodiments, the placing step includes the step of orienting the focal deflector away from the lumen axis and away from the target tissue.
- The applying step may include the step of expanding the focal deflector, such as by applying an actuation force to the focal deflector. The focal deflector may also be locked in its expanded configuration. In some embodiments the applying and expanding steps may include expanding the distal anchor to anchor within the lumen; applying a proximally directed force on the device; expanding the focal deflector while applying the proximally directed force; applying a proximally directed force on the device after expanding the focal deflector; and expanding the proximal anchor while applying the proximally directed force of the previous step.
- Yet another aspect of the invention is a tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In some embodiments the device includes an expandable anchor; a focal deflector; a connector disposed between the anchor and the focal deflector; and a tail extending from the focal deflector away from the anchor. The focal deflector may include an expandable portion. In some embodiments, the focal deflector is adapted to extend away from the lumen axis and away from the target tissue when the device is deployed in the lumen.
- One application for the device of this invention is in the treatment of mitral valve regurgitation. The invention will be described in further detail below with reference to the drawings.
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FIG. 1 shows a tissue reshaping device according to one aspect of the invention deployed in a coronary sinus to reshape the mitral valve annulus to treat mitral valve regurgitation. -
FIG. 2 is a perspective view of the device shown inFIG. 1 . -
FIG. 3 shows another embodiment of the invention. -
FIG. 4 shows another embodiment of the invention and its use to treat mitral valve regurgitation. -
FIG. 5 is a perspective view of the device shown inFIG. 4 . -
FIG. 6 shows an embodiment in which the focal deflector faces in the same direction as the anchors. -
FIG. 7 shows yet another embodiment of the invention deployed in a coronary sinus to reshape the mitral valve annulus to treat mitral valve regurgitation. -
FIG. 8 is a perspective view of the device shown inFIG. 7 . -
FIG. 9 shows yet another embodiment of the invention. -
FIG. 10 shows still another embodiment of the invention. -
FIG. 11 shows the focal deflector of the embodiment ofFIG. 10 . -
FIG. 12 is yet another view of the focal deflector of the embodiment ofFIG. 10 . -
FIG. 13 shows yet another embodiment of the invention. -
FIG. 14 shows an embodiment of the invention with a tail portion extending from the focal deflector. -
FIG. 15 illustrates one method for delivering an intravascular support to a desired location in the body. - Tissue shaping devices that apply force to a localized, discrete portion of the vessel wall surrounding a lumen have been described. See, e.g., U.S. patent application Ser. No. 10/003,910, “Focused Compression Mitral Valve Device and Method,” which describes the use of such devices disposed in the coronary sinus to treat mitral valve regurgitation. Other therapies deploy one or more rigid devices in the lumen to change the shape of the lumen and adjacent tissue. See, e.g., Lashinski et al. U.S. patent application Ser. No. 10/066,302 (published as U.S. 2002/0151961 A1); Taylor et al. U.S. patent application Ser. No. 10/068,264 (published as U.S. 2002/0183835 A1); Liddicoat et al. U.S. patent application Ser. No. 10/112,354 (published as U.S. 2002/0183838 A1); the disclosures of which are incorporated herein by reference. Still other tissue shaping devices utilize an “anchor and cinch” method to modify tissue adjacent a lumen, i.e., by anchoring a distal anchor, placing a proximally-directed force on a connector extending proximally from the distal anchor, and anchoring a proximal anchor before ceasing the proximally directed force to maintain the device's configuration and the reshaping of the tissue.
- The present invention provides a device disposed in a lumen to reshape tissue adjacent to the lumen that includes a focal deflector tissue reshaper, two anchors and an optional connector to help maintain the position of the focal tissue reshaper within the lumen. The use of a focal deflector tissue reshaper aimed at target tissue adjacent to the lumen minimizes the risk of adverse consequences from altering the shape of non-target tissue adjacent to other parts of the lumen. The anchors and/or connector may also be used to help reshape the target tissue.
-
FIGS. 1 and 2 show atissue reshaping device 10 according to one aspect of this invention.Device 10 is designed to be disposed in the coronary sinus or other cardiac vein to treat mitral valve regurgitation. It should be understood that such devices may also be used in other body lumens to reshape other tissue. - As shown in
FIGS. 1 and 2 ,device 10 has aproximal anchor 12 and adistal anchor 14 connected by aconnector 15. In the embodiment shown inFIGS. 1 and 2 , theanchors FIG. 8 configuration.Crimps connector 15. In the embodiment shown inFIG. 1 , crimps 16 and 18 are formed from wound wire, such as nitinol. In the embodiment shown inFIG. 2 , crimps 16 and 18 are formed from metal tubes, such as titanium tubes. -
Device 10 is delivered via a catheter to the treatment site within the lumen in a collapsed or unexpanded configuration. After expellingdevice 10 from the catheter at the treatment site (either by advancing the device distally out of the end of the catheter or by moving the end of the catheter proximally while maintaining the device stationary), the device's anchors begin to self-expand. At the proximal end of each anchor is aneyelet eyelets anchors -
Device 10 has afocal deflector 28 facing away from theanchors focal deflector 28 is formed as a bend in theconnector 15. As shown inFIG. 1 , when disposed in lumen 30 (shown here as the coronary sinus), the orientation ofdevice 10 placesfocal deflector 28 against thetarget tissue 37 to reshape themitral valve annulus 38.Device 10 may be curved to help ensure this orientation. For delivery via a catheter,focal deflector 28 is deformed and assumes the shape shown inFIGS. 1 and 2 after deployment from the catheter. - Because of the action of
focal deflector 28, the desired reshaping of the mitral valve annulus may be achieved with less cinching than other device designs or even with no cinching. Thus, the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors. In addition, with less or no cinching, any undesirable effect on non-target tissue adjacent the connector is also minimized. On the other hand, should reshaping adjacent to the anchors and/or connector be desired, such reshaping can be achieved through a combination of expansion of the anchors and cinching of the connector between them. The cinching is performed as with prior devices: by anchoring a distal anchor, placing a proximally-directed force on a connector extending proximally from the distal anchor, and anchoring a proximal anchor before ceasing the proximally directed force to maintain the device's configuration and the reshaping of the tissue. -
FIG. 3 shows another embodiment of the invention. As in the embodiment ofFIGS. 1 and 2 ,device 40 inFIG. 3 has twoanchors connector 46.Connector 46 is formed as a ribbon, preferably from a shape memory material such as nitinol, with afocal deflector 48 formed therein. Theanchors - In use,
device 40 is delivered via catheter to the treatment site in a collapsed or unexpanded configuration.Device 40 is then deployed by expelling it from the catheter and expanding it within a lumen in a position and orientation that placesfocal deflector 48 against the lumen's vessel wall adjacent to the target tissue to modify the shape of the target tissue. While the device may also be cinched to provide additional reshaping, the amount of cinching required will be less, thereby minimizing the reshaping of any non-target tissue adjacent the lumen by the connector. In addition, as with the previous embodiment, anchors 42 and 44 do not need to be expanded as much, thereby minimizing the reshaping of the non-target tissue adjacent to the anchors. -
FIGS. 4 and 5 show yet another embodiment of the invention and its use to treat mitral valve regurgitation.Device 50 has proximal anddistal anchors connector 56.Anchors FIGS. 1-3 . - A
focal deflector 58 is disposed onconnector 56. In this embodiment,focal deflector 58 has substantially the same design asanchors Focal deflector 58 is formed from wire (preferably made from a shape memory material such as nitinol) and has aFIG. 8 configuration when expanded. Acrimp 62 attaches the wire to theconnector 56. The anchors and focal deflector are delivered via a catheter to the appropriate site within the lumen in an unexpanded configuration, then expanded to a deployed configuration through the application of actuation forces delivered by catheters or other known tools. Like the anchors,focal deflector 58 may be locked in its expanded configuration by advancing aneyelet 60 over alock bump 61. - As shown in
FIG. 4 , when disposed in a lumen such as the coronary sinus, the orientation ofdevice 50 placesfocal deflector 58 against the coronary sinus wall adjacent thetarget tissue 59 of themitral valve annulus 57 to reshape the mitral valve annulus.Device 50 may be curved to help ensure proper orientation. As with the other embodiments, because of the action offocal deflector 58, the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching. Thus, the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors. In addition, with less or no cinching, the effect on non-target tissue adjacent the connector is also minimized. - Because it can be expanded and locked like an anchor, the
focal deflector 58 ofFIGS. 4 and 5 can also be used like an anchor during a cinching operation. For example, after expanding and lockingdistal anchor 54, a proximally-directed force can be exerted on the portion ofconnector 56 extending betweendistal anchor 54 andfocal deflector 58 prior to expanding and lockingfocal deflector 58 to cinch the distal portion ofdevice 50. Likewise, after expanding and lockingfocal deflector 58, another proximally-directed force can be exerted on the portion ofconnector 56 extending betweenfocal deflector 58 andproximal anchor 52 prior to expanding and lockingproximal anchor 52 to cinch the proximal portion ofdevice 50. If cinching is needed to achieve the desired shape modification of the target tissue, the presence offocal deflector 58 enables a user to cinch the distal and proximal portions ofdevice 50 with different cinching forces. - The focal deflector shown in the embodiment of
FIGS. 4 and 5 may have other orientations. For example,FIG. 6 shows an embodiment in which thefocal deflector 68 ofdevice 60 faces in the same direction as theanchors FIGS. 4-6 may be self-expanding but not locking. -
FIGS. 7 and 8 show yet another embodiment of the invention. Like the other embodiments,device 70 has aproximal anchor 72 and adistal anchor 74 connected by aconnector 76. Disposed onconnector 76 is afocal deflector 78 formed as an expanded cut-out tube, such as a modified stent. - As shown in
FIG. 7 ,device 70 may be deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent tofocal deflector 78.Device 70 is delivered to in an expanded configuration to the treatment site, then expelled from the catheter.Anchors Focal deflector 78 may also self-expand to the configuration shown inFIGS. 7 and 8 . Alternatively,focal deflector 78 may be expanded by using a balloon catheter to provide the actuation force, as is well-known in the stent art. - As in the other embodiments, because of the action of
focal deflector 78, the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching. Thus, the anchors do not need to anchor as tightly and may be expanded less, thereby minimizing the reshaping of non-target tissue adjacent the anchors. In addition, with less or no cinching, the effect on non-target tissue adjacent the connector is also minimized. -
FIG. 9 shows an embodiment of adevice 80 with proximal anddistal anchors FIG. 8 design like other embodiments connected by aconnector 86. Afocal deflector 88 is formed as a flattened area inconnector 86. In this embodiment,connector 86 andfocal deflector 88 are formed from shape memory material wire, such as nitinol. WhileFIG. 9 showsconnector 86 andfocal deflector 88 as three discrete straight segments, any or all of these elements may be have a curve. In any variation on the embodiment ofFIG. 9 , however, thefocal deflector 88 is straighter than the connector portions extending distally and proximally from it to the distal and proximal anchors, respectively.Device 80 may be delivered and deployed at the treatment site in the same manner as the embodiments described above. -
FIGS. 10-12 show yet another embodiment of adevice 90 with proximal anddistal anchors FIG. 8 design like other embodiments connected by aconnector 96. Afocal deflector 98 is also formed with a wire 100 (preferably made from a shape memory material such as nitinol) bent into aFIG. 8 pattern. As shown in more detail inFIGS. 11 and 12 , instead of a wrapped wire or solid metal crimp,focal deflector 98 has a base 102 with two downwardly extendingstruts 104. The angular spread betweenstruts 104 helps orient the device within the lumen.Base 102 may be made from a laser-cut shape memory material such as nitinol. The combination of the expansion of anchor wire 100 (as in the embodiment shown inFIG. 6 ) with the downward pressure from struts 104 (as in the embodiments shown inFIGS. 1-3 ) provide for focal deflection of target tissue adjacent to the focal deflector. - As with other embodiments,
device 90 may be delivered via a catheter and deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent tofocal deflector 98. The device is in a deformed and unexpanded state within the catheter, and self-expands and reforms into the shape shown inFIG. 10 once expelled from the catheter. Theanchors anchor portion 100 offocal deflector 98 are further expanded and locked by advancing their respective eyelets over corresponding lock bumps on their proximal sides. - Because of the action of
focal deflector 98, the desired reshaping of the mitral valve annulus may be achieved with less or even with no cinching. Thus, theanchors focal deflector 98 is formed similar to an anchor, the presence offocal deflector 98 enables a user to cinch the distal and proximal portions ofdevice 90 with different cinching forces. - The embodiment of
FIG. 13 omits thewire 100 offocal deflector 98 but is identical to the embodiment ofFIGS. 10-12 in all other respects. -
FIG. 14 shows an embodiment of adevice 110 with aproximal anchor 112 formed in aFIG. 8 pattern, as in other embodiments. Afocal deflector 114 formed as an anchor in aFIG. 8 pattern, as in the embodiment ofFIG. 6 , is connected toproximal anchor 112 by aconnector 116. Atail 118 extends distally fromfocal deflector 114 formed from a wire bent in a loop. The loop has a circumference that allows the loop to engage the wall of the vessel in which the device is placed. The points of engagement between the loop and vessel depend on the relative diameters of the loop and vessel. When deployed in a curved vessel, such as the coronary sinus, the loop will follow the vessel's curve to orient the device correctly within the vessel. The ends of the wire are contained with acrimp 120. Asmall loop 122 is formed at the distal end oftail 118 to provide additional spring action to the tail. - As in the other embodiments,
device 110 may be delivered via a catheter and deployed in the coronary sinus to treat mitral valve regurgitation by reshaping the tissue adjacent tofocal deflector 114. The device is in a deformed and unexpanded state within the catheter, and self-expands and reforms into the shape shown inFIG. 14 once expelled from the catheter. Theproximal anchor 112 andfocal deflector 114 are further expanded and locked by advancing their respective eyelets over corresponding lock bumps on their proximal sides. -
Element 114 ofdevice 110 inFIG. 14 may be used as a distal anchor instead of as a focal deflector, of course. -
FIG. 15 illustrates one method for delivering anintravascular support 150 in accordance with the present invention to a desired location in the body. As indicated above,intravascular support 150 is preferably loaded into and routed to a desired location within acatheter 200 with the proximal and distal anchors in a collapsed or deformed condition. That is, theeyelet 172 of thedistal anchor 170 is positioned proximally of the distal lock 160 and theeyelet 142 of the proximal anchor is positioned proximal to theproximal lock 164. The physician ejects the distal end of the intravascular support from thecatheter 200 into the lumen by advancing the intravascular support or retracting the catheter or a combination thereof. A pusher (not shown) provides distal movement of the intravascular support with respect tocatheter 200, and a tether provides proximal movement of the intravascular support with respect tocatheter 200. Because of the inherent recoverability of the material from which it is formed, the distal anchor begins to expand as soon as it is outside the catheter. Once the intravascular support is properly positioned, theeyelet 172 of the distal anchor is pushed distally over the distal lock 160 so that thedistal anchor 170 further expands and locks in place to securely engage the lumen wall and remains in the expanded condition. Next, the proximal end of the support wire is tensioned by applying a proximally-directed force on the support wire and distal anchor to apply sufficient pressure on the tissue adjacent the support wire to modify the shape of that tissue. In the case of the mitral valve, fluoroscopy, ultrasound or other imaging technology may be used to see when the support wire supplies sufficient pressure on the mitral valve to aid in its complete closure with each ventricular contraction without otherwise adversely affecting the patient. Once the proper pressure of the support wire has been determined, the proximal anchor is deployed from the catheter and allowed to begin its expansion. Theeyelet 142 of the proximal anchor is advanced distally over theproximal lock 164 to expand and lock the proximal anchor, thereby securely engaging the lumen wall and maintaining the pressure of the support wire against the lumen wall. Finally, the mechanism for securing the proximal end of the intravascular support can be released. In one embodiment, the securement is made with abraided loop 202 at the end of the tether and ahitch pin 204. Thehitch pin 204 is withdrawn thereby releasing theloop 202 so it can be pulled through theproximal lock 164 at the proximal end of theintravascular support 150. - Other modifications of the device are within the scope of the invention. For example, the anchors may be of some other design known in the art. In addition, the focal deflector may have some other shape designed to make the desired change in the target tissue.
Claims (19)
1. A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen, the device comprising:
first and second anchors;
a connector disposed between the first and second anchors; and
a focal deflector disposed between the first and second anchors.
2. The device of claim 1 wherein the lumen has a lumen axis, the focal deflector being adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
3. The device of claim 1 wherein the lumen has a lumen axis, the focal deflector being adapted to extend away from the lumen axis and away from the target tissue when the device is deployed in the lumen.
4. The device of claim 1 wherein the focal deflector comprises an expandable portion.
5. The device of claim 4 wherein the expandable portion is adapted to be self-expanding.
6. The device of claim 4 wherein the expandable portion is adapted to be expanded by an actuation force.
7. The device of claim 4 further comprising a lock locking the focal deflector in an expanded configuration.
8. The device of claim 1 further comprising an attachment element attaching the focal deflector to the connector.
9. The device of claim 1 wherein the focal deflector is integral with the connector.
10. The device of claim 9 wherein the focal deflector comprises a bend in the connector.
11. The device of claim 10 wherein the lumen has a lumen axis, the focal deflector being adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
12. The device of claim 9 wherein the connector has a linear shape, the focal deflector comprising a local change to the linear shape.
13. The device of claim 12 wherein the connector linear shape is a curved line, the focal deflector comprising a portion of increased curve of the curved line.
14. The device of claim 9 wherein the focal deflector comprises a flattened portion of the connector.
15. The device of claim 1 wherein the focal deflector comprises an expandable anchor.
16. The device of claim 15 wherein the lumen has a lumen axis, the focal deflector further comprising a portion integral with the connector and adapted to extend away from the lumen axis and toward the target tissue when the device is deployed in the lumen.
17. A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen, the device comprising:
an expandable anchor;
a focal deflector;
a connector disposed between the anchor and the focal deflector; and
a tail extending from the focal deflector away from the anchor.
18. The tissue shaping device of claim 17 wherein the focal deflector comprises an expandable portion.
19. The device of claim 17 wherein the lumen has a lumen axis, the focal deflector being adapted to extend away from the lumen axis and away from the target tissue when the device is deployed in the lumen.
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050187619A1 (en) * | 2002-05-08 | 2005-08-25 | Mathis Mark L. | Body lumen device anchor, device and assembly |
US20060276891A1 (en) * | 2003-12-19 | 2006-12-07 | Gregory Nieminen | Mitral Valve Annuloplasty Device with Twisted Anchor |
US20080015407A1 (en) * | 2003-05-02 | 2008-01-17 | Mathis Mark L | Device and Method for Modifying the Shape of a Body Organ |
US8172898B2 (en) | 2001-12-05 | 2012-05-08 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US8250960B2 (en) | 2008-08-11 | 2012-08-28 | Cardiac Dimensions, Inc. | Catheter cutting tool |
US9320600B2 (en) | 2002-01-30 | 2016-04-26 | Cardiac Dimensions Pty. Ltd. | Tissue shaping device |
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US10390953B2 (en) | 2017-03-08 | 2019-08-27 | Cardiac Dimensions Pty. Ltd. | Methods and devices for reducing paravalvular leakage |
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US11285005B2 (en) | 2006-07-17 | 2022-03-29 | Cardiac Dimensions Pty. Ltd. | Mitral valve annuloplasty device with twisted anchor |
US11285003B2 (en) | 2018-03-20 | 2022-03-29 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6406420B1 (en) * | 1997-01-02 | 2002-06-18 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
US6332893B1 (en) * | 1997-12-17 | 2001-12-25 | Myocor, Inc. | Valve to myocardium tension members device and method |
US7507252B2 (en) * | 2000-01-31 | 2009-03-24 | Edwards Lifesciences Ag | Adjustable transluminal annuloplasty system |
US6537198B1 (en) * | 2000-03-21 | 2003-03-25 | Myocor, Inc. | Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly |
US6616684B1 (en) * | 2000-10-06 | 2003-09-09 | Myocor, Inc. | Endovascular splinting devices and methods |
US6723038B1 (en) * | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US7510576B2 (en) * | 2001-01-30 | 2009-03-31 | Edwards Lifesciences Ag | Transluminal mitral annuloplasty |
US6800090B2 (en) * | 2001-05-14 | 2004-10-05 | Cardiac Dimensions, Inc. | Mitral valve therapy device, system and method |
US7311729B2 (en) * | 2002-01-30 | 2007-12-25 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US7635387B2 (en) * | 2001-11-01 | 2009-12-22 | Cardiac Dimensions, Inc. | Adjustable height focal tissue deflector |
US6908478B2 (en) * | 2001-12-05 | 2005-06-21 | Cardiac Dimensions, Inc. | Anchor and pull mitral valve device and method |
US6764510B2 (en) * | 2002-01-09 | 2004-07-20 | Myocor, Inc. | Devices and methods for heart valve treatment |
US20050209690A1 (en) * | 2002-01-30 | 2005-09-22 | Mathis Mark L | Body lumen shaping device with cardiac leads |
US6797001B2 (en) * | 2002-03-11 | 2004-09-28 | Cardiac Dimensions, Inc. | Device, assembly and method for mitral valve repair |
CA2877641C (en) * | 2002-05-08 | 2017-01-17 | Cardiac Dimensions Pty. Ltd. | Device and method for modifying the shape of a body organ |
US20030233022A1 (en) * | 2002-06-12 | 2003-12-18 | Vidlund Robert M. | Devices and methods for heart valve treatment |
US7112219B2 (en) * | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
US7316708B2 (en) | 2002-12-05 | 2008-01-08 | Cardiac Dimensions, Inc. | Medical device delivery system |
US7837729B2 (en) | 2002-12-05 | 2010-11-23 | Cardiac Dimensions, Inc. | Percutaneous mitral valve annuloplasty delivery system |
US7314485B2 (en) * | 2003-02-03 | 2008-01-01 | Cardiac Dimensions, Inc. | Mitral valve device using conditioned shape memory alloy |
US20040158321A1 (en) * | 2003-02-12 | 2004-08-12 | Cardiac Dimensions, Inc. | Method of implanting a mitral valve therapy device |
US20040254600A1 (en) * | 2003-02-26 | 2004-12-16 | David Zarbatany | Methods and devices for endovascular mitral valve correction from the left coronary sinus |
US20040220657A1 (en) * | 2003-05-02 | 2004-11-04 | Cardiac Dimensions, Inc., A Washington Corporation | Tissue shaping device with conformable anchors |
US20060161169A1 (en) * | 2003-05-02 | 2006-07-20 | Cardiac Dimensions, Inc., A Delaware Corporation | Device and method for modifying the shape of a body organ |
US7351259B2 (en) * | 2003-06-05 | 2008-04-01 | Cardiac Dimensions, Inc. | Device, system and method to affect the mitral valve annulus of a heart |
WO2005018507A2 (en) | 2003-07-18 | 2005-03-03 | Ev3 Santa Rosa, Inc. | Remotely activated mitral annuloplasty system and methods |
US7004176B2 (en) * | 2003-10-17 | 2006-02-28 | Edwards Lifesciences Ag | Heart valve leaflet locator |
US20050137449A1 (en) * | 2003-12-19 | 2005-06-23 | Cardiac Dimensions, Inc. | Tissue shaping device with self-expanding anchors |
US20050137450A1 (en) * | 2003-12-19 | 2005-06-23 | Cardiac Dimensions, Inc., A Washington Corporation | Tapered connector for tissue shaping device |
US7837728B2 (en) * | 2003-12-19 | 2010-11-23 | Cardiac Dimensions, Inc. | Reduced length tissue shaping device |
US7794496B2 (en) * | 2003-12-19 | 2010-09-14 | Cardiac Dimensions, Inc. | Tissue shaping device with integral connector and crimp |
US7993397B2 (en) * | 2004-04-05 | 2011-08-09 | Edwards Lifesciences Ag | Remotely adjustable coronary sinus implant |
US7211110B2 (en) * | 2004-12-09 | 2007-05-01 | Edwards Lifesciences Corporation | Diagnostic kit to assist with heart valve annulus adjustment |
US20060247491A1 (en) * | 2005-04-27 | 2006-11-02 | Vidlund Robert M | Devices and methods for heart valve treatment |
US7503932B2 (en) * | 2006-04-11 | 2009-03-17 | Cardiac Dimensions, Inc. | Mitral valve annuloplasty device with vena cava anchor |
US7854849B2 (en) * | 2006-10-10 | 2010-12-21 | Multiphase Systems Integration | Compact multiphase inline bulk water separation method and system for hydrocarbon production |
SE535690C2 (en) * | 2010-03-25 | 2012-11-13 | Jan Otto Solem | An implantable device and cardiac support kit, comprising means for generating longitudinal movement of the mitral valve |
GB201100137D0 (en) | 2011-01-06 | 2011-02-23 | Davies Helen C S | Apparatus and method of assessing a narrowing in a fluid tube |
CA2846058A1 (en) | 2011-08-20 | 2013-02-28 | Volcano Corporation | Devices, systems, and methods for visually depicting a vessel and evaluating treatment options |
US9339348B2 (en) | 2011-08-20 | 2016-05-17 | Imperial Colege of Science, Technology and Medicine | Devices, systems, and methods for assessing a vessel |
US10543088B2 (en) | 2012-09-14 | 2020-01-28 | Boston Scientific Scimed, Inc. | Mitral valve inversion prostheses |
US10849755B2 (en) | 2012-09-14 | 2020-12-01 | Boston Scientific Scimed, Inc. | Mitral valve inversion prostheses |
US9180005B1 (en) | 2014-07-17 | 2015-11-10 | Millipede, Inc. | Adjustable endolumenal mitral valve ring |
CN107530166B (en) | 2015-02-13 | 2020-01-31 | 魅尔皮德股份有限公司 | Valve replacement using a rotating anchor |
US10335275B2 (en) | 2015-09-29 | 2019-07-02 | Millipede, Inc. | Methods for delivery of heart valve devices using intravascular ultrasound imaging |
JP6892446B2 (en) | 2015-11-17 | 2021-06-23 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Implantable equipment and delivery system to reshape the heart valve annulus |
US20200146854A1 (en) | 2016-05-16 | 2020-05-14 | Elixir Medical Corporation | Methods and devices for heart valve repair |
US10363138B2 (en) * | 2016-11-09 | 2019-07-30 | Evalve, Inc. | Devices for adjusting the curvature of cardiac valve structures |
US10548731B2 (en) | 2017-02-10 | 2020-02-04 | Boston Scientific Scimed, Inc. | Implantable device and delivery system for reshaping a heart valve annulus |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5617854A (en) * | 1994-06-22 | 1997-04-08 | Munsif; Anand | Shaped catheter device and method |
US6045497A (en) * | 1997-01-02 | 2000-04-04 | Myocor, Inc. | Heart wall tension reduction apparatus and method |
US6162168A (en) * | 1997-01-02 | 2000-12-19 | Myocor, Inc. | Heart wall tension reduction apparatus |
US6478776B1 (en) * | 2000-04-05 | 2002-11-12 | Biocardia, Inc. | Implant delivery catheter system and methods for its use |
US6556873B1 (en) * | 1999-11-29 | 2003-04-29 | Medtronic, Inc. | Medical electrical lead having variable bending stiffness |
US6562066B1 (en) * | 2001-03-02 | 2003-05-13 | Eric C. Martin | Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium |
US7087064B1 (en) * | 2002-10-15 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Apparatuses and methods for heart valve repair |
US20080071364A1 (en) * | 2004-03-15 | 2008-03-20 | Baker Medical Research Institute | Treating Valve Failure |
US7955384B2 (en) * | 2003-11-12 | 2011-06-07 | Medtronic Vascular, Inc. | Coronary sinus approach for repair of mitral valve regurgitation |
US20120197389A1 (en) * | 2001-12-05 | 2012-08-02 | Alferness Clifton A | Device and Method for Modifying the Shape of a Body Organ |
Family Cites Families (199)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3974526A (en) | 1973-07-06 | 1976-08-17 | Dardik Irving I | Vascular prostheses and process for producing the same |
US3995623A (en) | 1974-12-23 | 1976-12-07 | American Hospital Supply Corporation | Multipurpose flow-directed catheter |
FR2306671A1 (en) | 1975-04-11 | 1976-11-05 | Rhone Poulenc Ind | VALVULAR IMPLANT |
US4164046A (en) | 1977-05-16 | 1979-08-14 | Cooley Denton | Valve prosthesis |
US4588395A (en) * | 1978-03-10 | 1986-05-13 | Lemelson Jerome H | Catheter and method |
US4485816A (en) | 1981-06-25 | 1984-12-04 | Alchemia | Shape-memory surgical staple apparatus and method for use in surgical suturing |
US4550870A (en) | 1983-10-13 | 1985-11-05 | Alchemia Ltd. Partnership | Stapling device |
CA1303298C (en) | 1986-08-06 | 1992-06-16 | Alain Carpentier | Flexible cardiac valvular support prosthesis |
US4830023A (en) * | 1987-11-27 | 1989-05-16 | Medi-Tech, Incorporated | Medical guidewire |
US5099838A (en) * | 1988-12-15 | 1992-03-31 | Medtronic, Inc. | Endocardial defibrillation electrode system |
JP2754067B2 (en) | 1989-01-17 | 1998-05-20 | 日本ゼオン株式会社 | Medical body wall hole plugging jig |
US5350420A (en) | 1989-07-31 | 1994-09-27 | Baxter International Inc. | Flexible annuloplasty ring and holder |
CA2026604A1 (en) * | 1989-10-02 | 1991-04-03 | Rodney G. Wolff | Articulated stent |
US5454365A (en) | 1990-11-05 | 1995-10-03 | Bonutti; Peter M. | Mechanically expandable arthroscopic retractors |
US5452733A (en) | 1993-02-22 | 1995-09-26 | Stanford Surgical Technologies, Inc. | Methods for performing thoracoscopic coronary artery bypass |
US5261916A (en) | 1991-12-12 | 1993-11-16 | Target Therapeutics | Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling |
US5265601A (en) | 1992-05-01 | 1993-11-30 | Medtronic, Inc. | Dual chamber cardiac pacing from a single electrode |
GB9213978D0 (en) * | 1992-07-01 | 1992-08-12 | Skidmore Robert | Medical devices |
US5250071A (en) | 1992-09-22 | 1993-10-05 | Target Therapeutics, Inc. | Detachable embolic coil assembly using interlocking clasps and method of use |
US5441515A (en) | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
WO1994027670A1 (en) * | 1993-06-02 | 1994-12-08 | Cardiac Pathways Corporation | Catheter having tip with fixation means |
FR2706309B1 (en) * | 1993-06-17 | 1995-10-06 | Sofamor | Instrument for surgical treatment of an intervertebral disc by the anterior route. |
US5458615A (en) | 1993-07-06 | 1995-10-17 | Advanced Cardiovascular Systems, Inc. | Stent delivery system |
FR2710254B1 (en) | 1993-09-21 | 1995-10-27 | Mai Christian | Multi-branch osteosynthesis clip with self-retaining dynamic compression. |
EP0657147B1 (en) | 1993-11-04 | 1999-08-04 | C.R. Bard, Inc. | Non-migrating vascular prosthesis |
US5728122A (en) * | 1994-01-18 | 1998-03-17 | Datascope Investment Corp. | Guide wire with releaseable barb anchor |
US5645560A (en) * | 1995-12-15 | 1997-07-08 | Cardiovascular Dynamics, Inc. | Fixed focal balloon for interactive angioplasty and stent implantation |
US5417708A (en) | 1994-03-09 | 1995-05-23 | Cook Incorporated | Intravascular treatment system and percutaneous release mechanism therefor |
US5449373A (en) | 1994-03-17 | 1995-09-12 | Medinol Ltd. | Articulated stent |
FR2718035B1 (en) | 1994-04-05 | 1996-08-30 | Ela Medical Sa | Method for controlling a double atrial pacemaker of the triple chamber type programmable in fallback mode. |
FR2718036B1 (en) * | 1994-04-05 | 1996-08-30 | Ela Medical Sa | Method for controlling a triple atrial pacemaker of the triple chamber type. |
EP0858298A4 (en) | 1994-04-29 | 1999-04-07 | Boston Scient Corp | Medical prosthetic stent and method of manufacture |
US5433727A (en) | 1994-08-16 | 1995-07-18 | Sideris; Eleftherios B. | Centering buttoned device for the occlusion of large defects for occluding |
US5899882A (en) * | 1994-10-27 | 1999-05-04 | Novoste Corporation | Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient |
US5879366A (en) * | 1996-12-20 | 1999-03-09 | W.L. Gore & Associates, Inc. | Self-expanding defect closure device and method of making and using |
US5575818A (en) | 1995-02-14 | 1996-11-19 | Corvita Corporation | Endovascular stent with locking ring |
US5554177A (en) | 1995-03-27 | 1996-09-10 | Medtronic, Inc. | Method and apparatus to optimize pacing based on intensity of acoustic signal |
US5693089A (en) | 1995-04-12 | 1997-12-02 | Inoue; Kanji | Method of collapsing an implantable appliance |
CA2218072A1 (en) | 1995-04-14 | 1996-10-17 | Schneider (Usa) Inc. | Rolling membrane stent delivery device |
US5601600A (en) * | 1995-09-08 | 1997-02-11 | Conceptus, Inc. | Endoluminal coil delivery system having a mechanical release mechanism |
JP2000503559A (en) * | 1995-12-14 | 2000-03-28 | ゴア エンタープライズ ホールディングス,インコーポレイティド | Apparatus and method for deploying a stent-graft |
US6053900A (en) * | 1996-02-16 | 2000-04-25 | Brown; Joe E. | Apparatus and method for delivering diagnostic and therapeutic agents intravascularly |
US5853422A (en) | 1996-03-22 | 1998-12-29 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US5827293A (en) * | 1996-05-13 | 1998-10-27 | Elliott; James B. | Subcutaneous insertion device |
BR9702255A (en) * | 1996-05-31 | 1999-02-17 | Bard Galway Ltd | Bifurcated endovascular extenders and methods and apparatus for placing them |
AU3182897A (en) * | 1996-06-20 | 1998-01-07 | Sulzer Vascutek Limited | Prosthetic repair of body passages |
US6015761A (en) * | 1996-06-26 | 2000-01-18 | Applied Materials, Inc. | Microwave-activated etching of dielectric layers |
US6077295A (en) * | 1996-07-15 | 2000-06-20 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent delivery system |
US5741297A (en) * | 1996-08-28 | 1998-04-21 | Simon; Morris | Daisy occluder and method for septal defect repair |
US5655548A (en) | 1996-09-16 | 1997-08-12 | Circulation, Inc. | Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion |
US6254628B1 (en) | 1996-12-09 | 2001-07-03 | Micro Therapeutics, Inc. | Intracranial stent |
US5895391A (en) * | 1996-09-27 | 1999-04-20 | Target Therapeutics, Inc. | Ball lock joint and introducer for vaso-occlusive member |
US6805128B1 (en) | 1996-10-22 | 2004-10-19 | Epicor Medical, Inc. | Apparatus and method for ablating tissue |
US5868781A (en) * | 1996-10-22 | 1999-02-09 | Scimed Life Systems, Inc. | Locking stent |
US6395017B1 (en) * | 1996-11-15 | 2002-05-28 | C. R. Bard, Inc. | Endoprosthesis delivery catheter with sequential stage control |
US6352561B1 (en) * | 1996-12-23 | 2002-03-05 | W. L. Gore & Associates | Implant deployment apparatus |
IL119911A (en) * | 1996-12-25 | 2001-03-19 | Niti Alloys Tech Ltd | Surgical clip |
US5961545A (en) | 1997-01-17 | 1999-10-05 | Meadox Medicals, Inc. | EPTFE graft-stent composite device |
US6241757B1 (en) | 1997-02-04 | 2001-06-05 | Solco Surgical Instrument Co., Ltd. | Stent for expanding body's lumen |
US5800393A (en) | 1997-03-07 | 1998-09-01 | Sahota; Harvinder | Wire perfusion catheter |
US6275730B1 (en) | 1997-03-14 | 2001-08-14 | Uab Research Foundation | Method and apparatus for treating cardiac arrythmia |
CA2283128A1 (en) | 1997-03-14 | 1998-09-17 | Raymond E. Ideker | Method and apparatus for treating cardiac arrhythmia |
US5836882A (en) | 1997-03-17 | 1998-11-17 | Frazin; Leon J. | Method and apparatus of localizing an insertion end of a probe within a biotic structure |
US5954761A (en) | 1997-03-25 | 1999-09-21 | Intermedics Inc. | Implantable endocardial lead assembly having a stent |
WO1998056435A1 (en) | 1997-06-13 | 1998-12-17 | Micro Therapeutics, Inc. | Contoured syringe and novel luer hub and methods for embolizing blood vessels |
FR2766374B1 (en) | 1997-07-24 | 2000-01-28 | Medex Sa | DEVICE FOR INJECTING A LIQUID FOR MEDICAL SYRINGE ASSOCIATED WITH THE DEVICE AND METHOD FOR PLACING THE SYRINGE |
US6007519A (en) | 1997-07-30 | 1999-12-28 | Rosselli; Matteo | Central access cannulation device |
US5984944A (en) | 1997-09-12 | 1999-11-16 | B. Braun Medical, Inc. | Introducer for an expandable vascular occlusion device |
US6096064A (en) | 1997-09-19 | 2000-08-01 | Intermedics Inc. | Four chamber pacer for dilated cardiomyopthy |
ES2290995T3 (en) | 1997-09-24 | 2008-02-16 | Med Institute, Inc. | RADIALLY EXPANDABLE ENDOPROTESIS. |
US6086611A (en) | 1997-09-25 | 2000-07-11 | Ave Connaught | Bifurcated stent |
US5928258A (en) | 1997-09-26 | 1999-07-27 | Corvita Corporation | Method and apparatus for loading a stent or stent-graft into a delivery sheath |
US6099552A (en) | 1997-11-12 | 2000-08-08 | Boston Scientific Corporation | Gastrointestinal copression clips |
US6342067B1 (en) * | 1998-01-09 | 2002-01-29 | Nitinol Development Corporation | Intravascular stent having curved bridges for connecting adjacent hoops |
US6190406B1 (en) * | 1998-01-09 | 2001-02-20 | Nitinal Development Corporation | Intravascular stent having tapered struts |
US6503271B2 (en) | 1998-01-09 | 2003-01-07 | Cordis Corporation | Intravascular device with improved radiopacity |
US6129755A (en) | 1998-01-09 | 2000-10-10 | Nitinol Development Corporation | Intravascular stent having an improved strut configuration |
US6345198B1 (en) * | 1998-01-23 | 2002-02-05 | Pacesetter, Inc. | Implantable stimulation system for providing dual bipolar sensing using an electrode positioned in proximity to the tricuspid valve and programmable polarity |
US6623521B2 (en) | 1998-02-17 | 2003-09-23 | Md3, Inc. | Expandable stent with sliding and locking radial elements |
DE69931152T2 (en) | 1998-03-27 | 2007-04-05 | Cook Urological Inc., Spencer | MINIMALLY INVASIVE APPARATUS FOR COLLECTING OBJECTS IN HOLLOWERS |
JP4399585B2 (en) * | 1998-06-02 | 2010-01-20 | クック インコーポレイティド | Multi-sided medical device |
US6250308B1 (en) | 1998-06-16 | 2001-06-26 | Cardiac Concepts, Inc. | Mitral valve annuloplasty ring and method of implanting |
NL1009551C2 (en) | 1998-07-03 | 2000-01-07 | Cordis Europ | Vena cava filter with improvements for controlled ejection. |
US6228098B1 (en) | 1998-07-10 | 2001-05-08 | General Surgical Innovations, Inc. | Apparatus and method for surgical fastening |
US6358276B1 (en) * | 1998-09-30 | 2002-03-19 | Impra, Inc. | Fluid containing endoluminal stent |
US6458092B1 (en) * | 1998-09-30 | 2002-10-01 | C. R. Bard, Inc. | Vascular inducing implants |
US7044134B2 (en) | 1999-11-08 | 2006-05-16 | Ev3 Sunnyvale, Inc | Method of implanting a device in the left atrial appendage |
US6214036B1 (en) | 1998-11-09 | 2001-04-10 | Cordis Corporation | Stent which is easily recaptured and repositioned within the body |
CA2317661C (en) | 1998-11-20 | 2008-04-15 | Medical Industries Corp. | Hemostatic material insertion device |
CN1775190B (en) | 1999-01-27 | 2010-06-16 | 梅德特龙尼克有限公司 | Cardiac valve procedure methods and devices |
US7018401B1 (en) * | 1999-02-01 | 2006-03-28 | Board Of Regents, The University Of Texas System | Woven intravascular devices and methods for making the same and apparatus for delivery of the same |
DE19910233A1 (en) | 1999-03-09 | 2000-09-21 | Jostra Medizintechnik Ag | Anuloplasty prosthesis |
ATE484241T1 (en) | 1999-04-09 | 2010-10-15 | Evalve Inc | METHOD AND DEVICE FOR HEART VALVE REPAIR |
US6183512B1 (en) * | 1999-04-16 | 2001-02-06 | Edwards Lifesciences Corporation | Flexible annuloplasty system |
US6317615B1 (en) | 1999-04-19 | 2001-11-13 | Cardiac Pacemakers, Inc. | Method and system for reducing arterial restenosis in the presence of an intravascular stent |
US6758830B1 (en) * | 1999-05-11 | 2004-07-06 | Atrionix, Inc. | Catheter positioning system |
US6602289B1 (en) | 1999-06-08 | 2003-08-05 | S&A Rings, Llc | Annuloplasty rings of particular use in surgery for the mitral valve |
US6626899B2 (en) | 1999-06-25 | 2003-09-30 | Nidus Medical, Llc | Apparatus and methods for treating tissue |
SE514718C2 (en) | 1999-06-29 | 2001-04-09 | Jan Otto Solem | Apparatus for treating defective closure of the mitral valve apparatus |
US6997951B2 (en) * | 1999-06-30 | 2006-02-14 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US7192442B2 (en) * | 1999-06-30 | 2007-03-20 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US6391038B2 (en) | 1999-07-28 | 2002-05-21 | Cardica, Inc. | Anastomosis system and method for controlling a tissue site |
FR2799364B1 (en) | 1999-10-12 | 2001-11-23 | Jacques Seguin | MINIMALLY INVASIVE CANCELING DEVICE |
US6613075B1 (en) | 1999-10-27 | 2003-09-02 | Cordis Corporation | Rapid exchange self-expanding stent delivery catheter system |
US6368284B1 (en) | 1999-11-16 | 2002-04-09 | Cardiac Intelligence Corporation | Automated collection and analysis patient care system and method for diagnosing and monitoring myocardial ischemia and outcomes thereof |
CN1243520C (en) | 2000-01-14 | 2006-03-01 | 维亚科公司 | Tissue annuloplasty band and apparatus and method for fashioning, sizing and implanting the same |
US6929653B2 (en) | 2000-12-15 | 2005-08-16 | Medtronic, Inc. | Apparatus and method for replacing aortic valve |
US7507252B2 (en) | 2000-01-31 | 2009-03-24 | Edwards Lifesciences Ag | Adjustable transluminal annuloplasty system |
US6402781B1 (en) | 2000-01-31 | 2002-06-11 | Mitralife | Percutaneous mitral annuloplasty and cardiac reinforcement |
US6989028B2 (en) | 2000-01-31 | 2006-01-24 | Edwards Lifesciences Ag | Medical system and method for remodeling an extravascular tissue structure |
US6821297B2 (en) | 2000-02-02 | 2004-11-23 | Robert V. Snyders | Artificial heart valve, implantation instrument and method therefor |
US6358195B1 (en) * | 2000-03-09 | 2002-03-19 | Neoseed Technology Llc | Method and apparatus for loading radioactive seeds into brachytherapy needles |
US6569198B1 (en) * | 2000-03-31 | 2003-05-27 | Richard A. Wilson | Mitral or tricuspid valve annuloplasty prosthetic device |
US6442427B1 (en) | 2000-04-27 | 2002-08-27 | Medtronic, Inc. | Method and system for stimulating a mammalian heart |
IL136213A0 (en) | 2000-05-17 | 2001-05-20 | Xtent Medical Inc | Selectively expandable and releasable stent |
US6334864B1 (en) * | 2000-05-17 | 2002-01-01 | Aga Medical Corp. | Alignment member for delivering a non-symmetric device with a predefined orientation |
US6589208B2 (en) | 2000-06-20 | 2003-07-08 | Applied Medical Resources Corporation | Self-deploying catheter assembly |
EP1330189B1 (en) * | 2000-06-23 | 2007-12-19 | Viacor Incorporated | Automated annular plication for mitral valve repair |
AU2001273088A1 (en) * | 2000-06-30 | 2002-01-30 | Viacor Incorporated | Intravascular filter with debris entrapment mechanism |
EP1401358B1 (en) * | 2000-06-30 | 2016-08-17 | Medtronic, Inc. | Apparatus for performing a procedure on a cardiac valve |
US6419696B1 (en) | 2000-07-06 | 2002-07-16 | Paul A. Spence | Annuloplasty devices and related heart valve repair methods |
US6773446B1 (en) | 2000-08-02 | 2004-08-10 | Cordis Corporation | Delivery apparatus for a self-expanding stent |
WO2002019951A1 (en) | 2000-09-07 | 2002-03-14 | Viacor, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
WO2004030569A2 (en) | 2002-10-01 | 2004-04-15 | Ample Medical, Inc. | Devices, systems, and methods for reshaping a heart valve annulus |
US6602288B1 (en) | 2000-10-05 | 2003-08-05 | Edwards Lifesciences Corporation | Minimally-invasive annuloplasty repair segment delivery template, system and method of use |
US6723038B1 (en) * | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US6913608B2 (en) | 2000-10-23 | 2005-07-05 | Viacor, Inc. | Automated annular plication for mitral valve repair |
US7070618B2 (en) * | 2000-10-25 | 2006-07-04 | Viacor, Inc. | Mitral shield |
AU2002220270A1 (en) | 2000-10-27 | 2002-05-06 | Viacor, Inc. | Intracardiovascular access (icvatm) system |
DE10058730A1 (en) * | 2000-11-25 | 2003-01-02 | Buhler Motor Gmbh | Adjustment device for motor vehicle exterior mirrors |
US7591826B2 (en) | 2000-12-28 | 2009-09-22 | Cardiac Dimensions, Inc. | Device implantable in the coronary sinus to provide mitral valve therapy |
US7510576B2 (en) * | 2001-01-30 | 2009-03-31 | Edwards Lifesciences Ag | Transluminal mitral annuloplasty |
JP4195612B2 (en) | 2001-01-30 | 2008-12-10 | エドワーズ ライフサイエンシーズ アーゲー | Medical system and method for improving extracorporeal tissue structure |
US6810882B2 (en) | 2001-01-30 | 2004-11-02 | Ev3 Santa Rosa, Inc. | Transluminal mitral annuloplasty |
EP1363559A4 (en) | 2001-02-05 | 2008-10-01 | Viacor Inc | Apparatus and method for reducing mitral regurgitation |
US6656221B2 (en) | 2001-02-05 | 2003-12-02 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
AU2002240363A1 (en) | 2001-02-13 | 2002-08-28 | Quetzal Biomedical, Inc. | Multi-electrode apparatus and method for treatment of congestive heart failure |
WO2002096275A2 (en) | 2001-03-05 | 2002-12-05 | Viacor, Incorporated | Apparatus and method for reducing mitral regurgitation |
US6899734B2 (en) * | 2001-03-23 | 2005-05-31 | Howmedica Osteonics Corp. | Modular implant for fusing adjacent bone structure |
US6890353B2 (en) | 2001-03-23 | 2005-05-10 | Viacor, Inc. | Method and apparatus for reducing mitral regurgitation |
EP1383448B1 (en) | 2001-03-29 | 2008-06-04 | Viacor, Inc. | Apparatus for improving mitral valve function |
US7186264B2 (en) | 2001-03-29 | 2007-03-06 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
US6733521B2 (en) * | 2001-04-11 | 2004-05-11 | Trivascular, Inc. | Delivery system and method for endovascular graft |
US6619291B2 (en) * | 2001-04-24 | 2003-09-16 | Edwin J. Hlavka | Method and apparatus for catheter-based annuloplasty |
US20020188170A1 (en) | 2001-04-27 | 2002-12-12 | Santamore William P. | Prevention of myocardial infarction induced ventricular expansion and remodeling |
US6837901B2 (en) | 2001-04-27 | 2005-01-04 | Intek Technology L.L.C. | Methods for delivering, repositioning and/or retrieving self-expanding stents |
US6800090B2 (en) * | 2001-05-14 | 2004-10-05 | Cardiac Dimensions, Inc. | Mitral valve therapy device, system and method |
US6676702B2 (en) | 2001-05-14 | 2004-01-13 | Cardiac Dimensions, Inc. | Mitral valve therapy assembly and method |
US6599314B2 (en) | 2001-06-08 | 2003-07-29 | Cordis Corporation | Apparatus and method for stenting a vessel using balloon-actuated stent with interlocking elements |
US6629994B2 (en) | 2001-06-11 | 2003-10-07 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
US20030078654A1 (en) * | 2001-08-14 | 2003-04-24 | Taylor Daniel C. | Method and apparatus for improving mitral valve function |
US6721598B1 (en) * | 2001-08-31 | 2004-04-13 | Pacesetter, Inc. | Coronary sinus cardiac lead for stimulating and sensing in the right and left heart and system |
US6776784B2 (en) | 2001-09-06 | 2004-08-17 | Core Medical, Inc. | Clip apparatus for closing septal defects and methods of use |
PT1423066E (en) * | 2001-09-07 | 2008-09-29 | Mardil Inc | Method and apparatus for external heart stabilization |
US7144363B2 (en) | 2001-10-16 | 2006-12-05 | Extensia Medical, Inc. | Systems for heart treatment |
AUPR847301A0 (en) * | 2001-10-26 | 2001-11-15 | Cook Incorporated | Endoluminal prostheses for curved lumens |
US7052487B2 (en) | 2001-10-26 | 2006-05-30 | Cohn William E | Method and apparatus for reducing mitral regurgitation |
US6949122B2 (en) * | 2001-11-01 | 2005-09-27 | Cardiac Dimensions, Inc. | Focused compression mitral valve device and method |
US7311729B2 (en) | 2002-01-30 | 2007-12-25 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US7635387B2 (en) * | 2001-11-01 | 2009-12-22 | Cardiac Dimensions, Inc. | Adjustable height focal tissue deflector |
US6824562B2 (en) | 2002-05-08 | 2004-11-30 | Cardiac Dimensions, Inc. | Body lumen device anchor, device and assembly |
US6908478B2 (en) | 2001-12-05 | 2005-06-21 | Cardiac Dimensions, Inc. | Anchor and pull mitral valve device and method |
US6793673B2 (en) * | 2002-12-26 | 2004-09-21 | Cardiac Dimensions, Inc. | System and method to effect mitral valve annulus of a heart |
US6976995B2 (en) | 2002-01-30 | 2005-12-20 | Cardiac Dimensions, Inc. | Fixed length anchor and pull mitral valve device and method |
DE10161543B4 (en) | 2001-12-11 | 2004-02-19 | REITAN, Öyvind | Implant for the treatment of heart valve insufficiency |
SE524709C2 (en) * | 2002-01-11 | 2004-09-21 | Edwards Lifesciences Ag | Device for delayed reshaping of a heart vessel and a heart valve |
WO2003055417A1 (en) | 2001-12-28 | 2003-07-10 | Edwards Lifesciences Ag | Delayed memory device |
US6764510B2 (en) | 2002-01-09 | 2004-07-20 | Myocor, Inc. | Devices and methods for heart valve treatment |
WO2003105670A2 (en) * | 2002-01-10 | 2003-12-24 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US6960229B2 (en) | 2002-01-30 | 2005-11-01 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US20050209690A1 (en) * | 2002-01-30 | 2005-09-22 | Mathis Mark L | Body lumen shaping device with cardiac leads |
US7125420B2 (en) * | 2002-02-05 | 2006-10-24 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
US7004958B2 (en) * | 2002-03-06 | 2006-02-28 | Cardiac Dimensions, Inc. | Transvenous staples, assembly and method for mitral valve repair |
US6797001B2 (en) * | 2002-03-11 | 2004-09-28 | Cardiac Dimensions, Inc. | Device, assembly and method for mitral valve repair |
CA2877641C (en) | 2002-05-08 | 2017-01-17 | Cardiac Dimensions Pty. Ltd. | Device and method for modifying the shape of a body organ |
US20040243227A1 (en) | 2002-06-13 | 2004-12-02 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US8287555B2 (en) | 2003-02-06 | 2012-10-16 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US7175660B2 (en) | 2002-08-29 | 2007-02-13 | Mitralsolutions, Inc. | Apparatus for implanting surgical devices for controlling the internal circumference of an anatomic orifice or lumen |
US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
US7247134B2 (en) | 2002-11-12 | 2007-07-24 | Myocor, Inc. | Devices and methods for heart valve treatment |
US20040098116A1 (en) * | 2002-11-15 | 2004-05-20 | Callas Peter L. | Valve annulus constriction apparatus and method |
US7485143B2 (en) | 2002-11-15 | 2009-02-03 | Abbott Cardiovascular Systems Inc. | Apparatuses and methods for heart valve repair |
US7316708B2 (en) | 2002-12-05 | 2008-01-08 | Cardiac Dimensions, Inc. | Medical device delivery system |
US7837729B2 (en) * | 2002-12-05 | 2010-11-23 | Cardiac Dimensions, Inc. | Percutaneous mitral valve annuloplasty delivery system |
US20040133240A1 (en) | 2003-01-07 | 2004-07-08 | Cardiac Dimensions, Inc. | Electrotherapy system, device, and method for treatment of cardiac valve dysfunction |
US7314485B2 (en) | 2003-02-03 | 2008-01-01 | Cardiac Dimensions, Inc. | Mitral valve device using conditioned shape memory alloy |
US20040158321A1 (en) | 2003-02-12 | 2004-08-12 | Cardiac Dimensions, Inc. | Method of implanting a mitral valve therapy device |
US20040220657A1 (en) | 2003-05-02 | 2004-11-04 | Cardiac Dimensions, Inc., A Washington Corporation | Tissue shaping device with conformable anchors |
US20060161169A1 (en) | 2003-05-02 | 2006-07-20 | Cardiac Dimensions, Inc., A Delaware Corporation | Device and method for modifying the shape of a body organ |
US20040220654A1 (en) * | 2003-05-02 | 2004-11-04 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US7351259B2 (en) | 2003-06-05 | 2008-04-01 | Cardiac Dimensions, Inc. | Device, system and method to affect the mitral valve annulus of a heart |
WO2005018507A2 (en) * | 2003-07-18 | 2005-03-03 | Ev3 Santa Rosa, Inc. | Remotely activated mitral annuloplasty system and methods |
US7794496B2 (en) | 2003-12-19 | 2010-09-14 | Cardiac Dimensions, Inc. | Tissue shaping device with integral connector and crimp |
US20050137450A1 (en) | 2003-12-19 | 2005-06-23 | Cardiac Dimensions, Inc., A Washington Corporation | Tapered connector for tissue shaping device |
US20060271174A1 (en) | 2003-12-19 | 2006-11-30 | Gregory Nieminen | Mitral Valve Annuloplasty Device with Wide Anchor |
US9526616B2 (en) | 2003-12-19 | 2016-12-27 | Cardiac Dimensions Pty. Ltd. | Mitral valve annuloplasty device with twisted anchor |
US20050137449A1 (en) | 2003-12-19 | 2005-06-23 | Cardiac Dimensions, Inc. | Tissue shaping device with self-expanding anchors |
US7837728B2 (en) | 2003-12-19 | 2010-11-23 | Cardiac Dimensions, Inc. | Reduced length tissue shaping device |
AU2006206254B2 (en) | 2005-01-20 | 2012-02-09 | Cardiac Dimensions Pty. Ltd. | Tissue shaping device |
-
2004
- 2004-05-05 US US10/840,188 patent/US7887582B2/en active Active
-
2011
- 2011-01-11 US US13/004,239 patent/US20110106117A1/en not_active Abandoned
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5617854A (en) * | 1994-06-22 | 1997-04-08 | Munsif; Anand | Shaped catheter device and method |
US6045497A (en) * | 1997-01-02 | 2000-04-04 | Myocor, Inc. | Heart wall tension reduction apparatus and method |
US6162168A (en) * | 1997-01-02 | 2000-12-19 | Myocor, Inc. | Heart wall tension reduction apparatus |
US6556873B1 (en) * | 1999-11-29 | 2003-04-29 | Medtronic, Inc. | Medical electrical lead having variable bending stiffness |
US6478776B1 (en) * | 2000-04-05 | 2002-11-12 | Biocardia, Inc. | Implant delivery catheter system and methods for its use |
US6562066B1 (en) * | 2001-03-02 | 2003-05-13 | Eric C. Martin | Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium |
US20120197389A1 (en) * | 2001-12-05 | 2012-08-02 | Alferness Clifton A | Device and Method for Modifying the Shape of a Body Organ |
US7087064B1 (en) * | 2002-10-15 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Apparatuses and methods for heart valve repair |
US7955384B2 (en) * | 2003-11-12 | 2011-06-07 | Medtronic Vascular, Inc. | Coronary sinus approach for repair of mitral valve regurgitation |
US20080071364A1 (en) * | 2004-03-15 | 2008-03-20 | Baker Medical Research Institute | Treating Valve Failure |
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US20050010240A1 (en) | 2005-01-13 |
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