US20120197219A1 - Ergonomic Hand-Operable Fluid-Dispensing Device - Google Patents

Ergonomic Hand-Operable Fluid-Dispensing Device Download PDF

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Publication number
US20120197219A1
US20120197219A1 US13/018,889 US201113018889A US2012197219A1 US 20120197219 A1 US20120197219 A1 US 20120197219A1 US 201113018889 A US201113018889 A US 201113018889A US 2012197219 A1 US2012197219 A1 US 2012197219A1
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United States
Prior art keywords
pump mechanism
fluid composition
actuator
force
hand
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Granted
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US13/018,889
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US9186690B2 (en
Inventor
Christopher M. Scanlon
Patrick J. McCormick
Dana Matsuzaki
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Bausch and Lomb Inc
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Individual
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Priority to US13/018,889 priority Critical patent/US9186690B2/en
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Priority to PCT/US2012/021053 priority patent/WO2012106082A1/en
Priority to EP12701401.7A priority patent/EP2670535A1/en
Priority to MX2013007719A priority patent/MX337227B/en
Priority to CN2012800061767A priority patent/CN103328111A/en
Priority to CA2822691A priority patent/CA2822691C/en
Priority to TW101102286A priority patent/TWI544939B/en
Priority to ARP120100289A priority patent/AR085098A1/en
Publication of US20120197219A1 publication Critical patent/US20120197219A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0059—Components or details allowing operation in any orientation, e.g. for discharge in inverted position
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1038—Pressure accumulation pumps, i.e. pumps comprising a pressure accumulation chamber
    • B05B11/104—Pressure accumulation pumps, i.e. pumps comprising a pressure accumulation chamber the outlet valve being opened by pressure after a defined accumulation stroke
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/105—Sealing arrangements around pump actuating stem
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1052—Actuation means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1094—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle having inlet or outlet valves not being actuated by pressure or having no inlet or outlet valve
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1066—Pump inlet valves
    • B05B11/107—Gate valves; Sliding valves

Definitions

  • the present invention relates to an ergonomic hand-operable fluid-dispensing device.
  • the present invention relates to an ergonomic hand-operable double-acting system for administering a fluid composition to an eye.
  • Ophthalmic disorders often require topical administration of fluid compositions to the affected eye.
  • the patient often must administer the medication on herself or himself.
  • eye drops are simply contained in a squeezable multi-use bottle from which the eye drops are dispensed through a simple bored-through nozzle.
  • a squeezable multi-use bottle presents the risk of contamination of the medication remaining in the bottle because the liquid that is not ejected completely from the nozzle after each use tends to flow back into the bottle when air is drawn in.
  • a device that can minimize or eliminate such risk of contamination employs a double-acting pump for ejecting the liquid from a bottle.
  • a double-acting pump for ejecting the liquid from a bottle.
  • One such device is disclosed in U.S. Pat. No. 6,851,583, which is incorporated herein by reference in its entirety.
  • the use of this device in the upside-down position for self administration of an eye drop is quite awkward, especially for patients with less flexibility.
  • the present invention provides a hand-operable device or system that is easily used by a patient for self administration of a fluid composition into an eye.
  • the present invention provides an ergonomic hand-operable device or system that is easily used by a patient for self administration of a fluid composition into an eye.
  • such a device or system comprises a double-acting pump mechanism for ejecting the fluid composition into an eye.
  • the double-acting pump mechanism is actuated by applying a force on an actuator that is disposed over, and extends radially outward from, said pump mechanism.
  • the present invention provides an ergonomic hand-operable system that is easily used by a patient for self administration of a fluid composition into an eye.
  • the system comprises: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying a force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off when the application of said force is discontinued.
  • FIG. 1 shows the cross section of a device of the present invention.
  • FIG. 2 shows detailed cross section of a double-acting pump mechanism that may be used in a device of the present invention.
  • FIG. 3 shows operation of a device of the present invention during administration of an eye drop.
  • FIG. 4 shows various views of a device of the present invention, including the top view and several side views.
  • the present invention provides a hand-operable device or system that is easily used by a patient for self administration of a fluid composition into an eye.
  • the present invention provides an ergonomic hand-operable device or system that is easily used by a patient for self administration of a fluid composition into an eye.
  • such a device or system comprises a double-acting pump mechanism for ejecting the fluid composition into an eye.
  • the double-acting pump mechanism is actuated by applying a force on an actuator that is disposed over, and extends radially outward from, said pump mechanism.
  • the present invention provides an ergonomic hand-operable system that is easily used by a patient for self administration of a fluid composition into an eye.
  • the system comprises: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying a force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off when the application of said force is discontinued.
  • the present invention provides an ergonomic hand-operable system that is easily used by a patient for self administration of a fluid composition into an eye.
  • the system comprises: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying an actuating force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off by longitudinal displacement of a piston over said passage under the restoring force of a spring when the application of said actuating force is discontinued.
  • FIG. 1 shows a cross section of a hand-operable device or system of the present invention.
  • the device or system comprises: (1) container 100 having container opening 104 and containing a fluid composition; (2) double-acting pump mechanism 10 securely disposed over container opening 104 ; and (3) actuator 80 that is disposed over, and extends radially outward from, said pump mechanism 10 , for actuating the pump mechanism 10 by applying a force thereon.
  • Double-acting pump mechanism 10 is tightly attached by a snap seat on the slightly radially protruding rim 105 of opening 104 of container 100 through a sealing ring disk 106 disposed between pump mechanism 10 and container 100 .
  • FIG. 2 shows a cross section of a double-acting pump mechanism that may be included in a device of the present invention. It should be understood that other designs of double-acting mechanisms may be equally suitable for inclusion in a device or system of the present invention.
  • Double-acting pump mechanism 10 includes a cup-shaped housing 12 .
  • a hollow cylindrical piston 16 is axially displaceable in housing 12 . Piston 16 is sealed relative to the inner side of housing 12 in a first housing portion 13 .
  • Bore 18 inside piston 16 extends axially and substantially through the length of piston 16 . Bore 18 can communicate with the fluid in container 100 through, for example a transverse channel formed in the wall of first housing portion 13 . Piston 16 is slidable in opening 20 of closing cap 22 that encloses housing 12 and securely and sealingly attaches double-acting mechanism 10 to container 100 .
  • Actuating head 26 of double-acting pump mechanism 10 is tightly and securely placed on the free end of piston 16 .
  • Actuating head 26 comprises an outer sleeve 28 and an inner sleeve 30 tightly disposed concentrically inside outer sleeve 28 .
  • a small channel 19 is formed transversely through the wall of hollow piston 16 at the distal end thereof.
  • a check valve 34 is fitted partially inside bore 18 at the distal end of hollow piston 16 . When pump mechanism 10 is at rest, check valve 34 sealingly covers channel 19 , preventing fluid from traversing therethrough.
  • a restoring spring 36 is disposed on check valve 34 and rests against shoulder 38 formed inside inner sleeve 30 .
  • a transverse bore 32 is formed through the wall of inner sleeve 30 at a small distance away from channel 19 such that check valve 34 covers both channel 19 and transverse bore 32 when pump mechanism 10 is at rest.
  • Transverse bore 32 communicates with a longitudinal groove 42 formed on the outer surface of inner sleeve 30 to direct the fluid composition flowing through transverse bore 32 to fluid ejection opening 44 formed in the distal end of outer sleeve 28 .
  • Actuating head 26 may be protected by a removable cap 54 when not in use.
  • actuating head 26 When double-acting pump mechanism 10 is actuated, actuating head 26 is pushed toward bottle 100 against spring 36 . As a result, channel 19 is aligned with transverse bore 32 , allowing fluid to flow from bore 18 through hollow piston 16 and inner sleeve 30 to groove 42 toward ejection opening 44 .
  • the restoring force of spring 36 moves actuating head 26 and piston 16 in opposite directions, and check valve 34 again covers both channel 19 and transverse bore 32 , thereby cuts off the flow of fluid therethrough.
  • an anti-microorganism material such as silver
  • Such anti-microorganism material may have an annular form, or is a disc made of a porous material having silver dispersed therein, fitted tightly in opening 44 .
  • actuator 80 is disposed over pump mechanism 10 , and extends radially outward therefrom, forming actuator shoulder 82 .
  • Pump mechanism 10 is actuated by, for example, applying a force on actuator shoulder 82 .
  • actuator 80 rests on shoulder 50 of actuating head 26 .
  • Actuator 80 extends longitudinally over at least a portion of bottle 100 , for example, to provide stability during operation of pump 10 .
  • FIG. 3 wherein a typical operation of a device or system of the present invention is carried out for administration of an eye drop to a patient.
  • the patient holds the device in one hand with a thumb resting on the portion of the actuator that extends radially away from the bottle (actuator shoulder 82 ).
  • the tip of the actuating head is directed to the eye.
  • the pump mechanism is actuated by applying a force on the actuator to move the actuating head toward the bottle containing the eye drop composition.
  • a drop of the fluid composition is ejected from the tip of actuating head 26 into the eye.
  • a system of the present invention is designed to be easily operated with one hand.
  • the total length of the device in the unactuated state may be about 3.5-4.5 inches (or about 8.9-11.4 cm).
  • the larger dimension of actuator shoulder 82 may be about 1.5-2 inches (or about 3.8-5 cm).
  • the diameter of the bottle nay be about 1-1.5 inch (or about 2.5-3.8 cm), and the bottle may contain about 10-15 ml of the fluid composition.
  • Actuator shoulder 82 is sized to accommodate a force applied by a thumb, and thus provides operational benefits especially to patients having limited flexibility.
  • actuator shoulder 82 on which a thumb rests may be provided with raised ridges or other similar designs to prevent slipping of the thumb.
  • said surface may be formed with a friction enhancing material.
  • Bottle 100 , actuator 80 , and various parts of pump mechanism 10 may be made of polymeric materials, such as polyethylene (e.g., pharmaceutical-grade high-density polyethylene), polyvinyl chloride, or polyethylene terephthalate.
  • polyethylene e.g., pharmaceutical-grade high-density polyethylene
  • polyvinyl chloride e.g., polyvinyl chloride
  • polyethylene terephthalate e.g., polyethylene terephthalate

Abstract

A hand-operable system for ejecting a fluid composition into an eye, the system comprises: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying a force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off when the application of said force is discontinued.

Description

    BACKGROUND OF THE INVENTION
  • The present invention relates to an ergonomic hand-operable fluid-dispensing device. In particular, the present invention relates to an ergonomic hand-operable double-acting system for administering a fluid composition to an eye.
  • Ophthalmic disorders often require topical administration of fluid compositions to the affected eye. The patient often must administer the medication on herself or himself. Typically, eye drops are simply contained in a squeezable multi-use bottle from which the eye drops are dispensed through a simple bored-through nozzle. However, such a squeezable multi-use bottle presents the risk of contamination of the medication remaining in the bottle because the liquid that is not ejected completely from the nozzle after each use tends to flow back into the bottle when air is drawn in.
  • A device that can minimize or eliminate such risk of contamination employs a double-acting pump for ejecting the liquid from a bottle. One such device is disclosed in U.S. Pat. No. 6,851,583, which is incorporated herein by reference in its entirety. However, the use of this device in the upside-down position for self administration of an eye drop is quite awkward, especially for patients with less flexibility.
  • Therefore, there is a continued need to provide a more ergonomic hand-operable device for self administration of a fluid composition into an eye. Moreover, it is also very desirable to provide such a device to patients with less flexibility to encourage compliance with the required treatment.
    • SUMMARY
  • In general, the present invention provides a hand-operable device or system that is easily used by a patient for self administration of a fluid composition into an eye.
  • In one aspect, the present invention provides an ergonomic hand-operable device or system that is easily used by a patient for self administration of a fluid composition into an eye.
  • In another aspect, such a device or system comprises a double-acting pump mechanism for ejecting the fluid composition into an eye.
  • In still another aspect, the double-acting pump mechanism is actuated by applying a force on an actuator that is disposed over, and extends radially outward from, said pump mechanism.
  • In still another aspect, the present invention provides an ergonomic hand-operable system that is easily used by a patient for self administration of a fluid composition into an eye. The system comprises: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying a force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off when the application of said force is discontinued.
  • Other features and advantages of the present invention will become apparent from the following detailed description and claims.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows the cross section of a device of the present invention.
  • FIG. 2 shows detailed cross section of a double-acting pump mechanism that may be used in a device of the present invention.
  • FIG. 3 shows operation of a device of the present invention during administration of an eye drop.
  • FIG. 4 shows various views of a device of the present invention, including the top view and several side views.
    •  DETAILED DESCRIPTION
  • In general, the present invention provides a hand-operable device or system that is easily used by a patient for self administration of a fluid composition into an eye.
  • In one aspect, the present invention provides an ergonomic hand-operable device or system that is easily used by a patient for self administration of a fluid composition into an eye.
  • In another aspect, such a device or system comprises a double-acting pump mechanism for ejecting the fluid composition into an eye.
  • In still another aspect, the double-acting pump mechanism is actuated by applying a force on an actuator that is disposed over, and extends radially outward from, said pump mechanism.
  • In still another aspect, the present invention provides an ergonomic hand-operable system that is easily used by a patient for self administration of a fluid composition into an eye. The system comprises: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying a force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off when the application of said force is discontinued.
  • In a further aspect, the present invention provides an ergonomic hand-operable system that is easily used by a patient for self administration of a fluid composition into an eye. The system comprises: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying an actuating force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off by longitudinal displacement of a piston over said passage under the restoring force of a spring when the application of said actuating force is discontinued.
  • An example of a double acting pump mechanism suitable for use with a device of the present invention is disclosed in U.S. Pat. No. 6,851,583, which is incorporated herein by reference in its entirety.
  • Reference is made to FIG. 1, which shows a cross section of a hand-operable device or system of the present invention. The device or system comprises: (1) container 100 having container opening 104 and containing a fluid composition; (2) double-acting pump mechanism 10 securely disposed over container opening 104; and (3) actuator 80 that is disposed over, and extends radially outward from, said pump mechanism 10, for actuating the pump mechanism 10 by applying a force thereon.
  • Double-acting pump mechanism 10 is tightly attached by a snap seat on the slightly radially protruding rim 105 of opening 104 of container 100 through a sealing ring disk 106 disposed between pump mechanism 10 and container 100. Reference is made to FIG. 2, which shows a cross section of a double-acting pump mechanism that may be included in a device of the present invention. It should be understood that other designs of double-acting mechanisms may be equally suitable for inclusion in a device or system of the present invention. Double-acting pump mechanism 10 includes a cup-shaped housing 12. A hollow cylindrical piston 16 is axially displaceable in housing 12. Piston 16 is sealed relative to the inner side of housing 12 in a first housing portion 13. Bore 18 inside piston 16 extends axially and substantially through the length of piston 16. Bore 18 can communicate with the fluid in container 100 through, for example a transverse channel formed in the wall of first housing portion 13. Piston 16 is slidable in opening 20 of closing cap 22 that encloses housing 12 and securely and sealingly attaches double-acting mechanism 10 to container 100.
  • An actuating head 26 of double-acting pump mechanism 10 is tightly and securely placed on the free end of piston 16. Actuating head 26 comprises an outer sleeve 28 and an inner sleeve 30 tightly disposed concentrically inside outer sleeve 28. A small channel 19 is formed transversely through the wall of hollow piston 16 at the distal end thereof. A check valve 34 is fitted partially inside bore 18 at the distal end of hollow piston 16. When pump mechanism 10 is at rest, check valve 34 sealingly covers channel 19, preventing fluid from traversing therethrough. A restoring spring 36 is disposed on check valve 34 and rests against shoulder 38 formed inside inner sleeve 30.
  • A transverse bore 32 is formed through the wall of inner sleeve 30 at a small distance away from channel 19 such that check valve 34 covers both channel 19 and transverse bore 32 when pump mechanism 10 is at rest. Transverse bore 32 communicates with a longitudinal groove 42 formed on the outer surface of inner sleeve 30 to direct the fluid composition flowing through transverse bore 32 to fluid ejection opening 44 formed in the distal end of outer sleeve 28.
  • Actuating head 26 may be protected by a removable cap 54 when not in use.
  • When double-acting pump mechanism 10 is actuated, actuating head 26 is pushed toward bottle 100 against spring 36. As a result, channel 19 is aligned with transverse bore 32, allowing fluid to flow from bore 18 through hollow piston 16 and inner sleeve 30 to groove 42 toward ejection opening 44. When the force on spring 36 is removed, the restoring force of spring 36 moves actuating head 26 and piston 16 in opposite directions, and check valve 34 again covers both channel 19 and transverse bore 32, thereby cuts off the flow of fluid therethrough. In addition, an anti-microorganism material (such as silver) may be disposed in ejection opening 44 to prevent the growth of microorganisms therein between uses. Such anti-microorganism material may have an annular form, or is a disc made of a porous material having silver dispersed therein, fitted tightly in opening 44.
  • Reference is now made to FIG. 1, actuator 80 is disposed over pump mechanism 10, and extends radially outward therefrom, forming actuator shoulder 82. Pump mechanism 10 is actuated by, for example, applying a force on actuator shoulder 82. In the embodiment shown in FIG. 1, actuator 80 rests on shoulder 50 of actuating head 26. Actuator 80 extends longitudinally over at least a portion of bottle 100, for example, to provide stability during operation of pump 10.
  • Reference is made to FIG. 3, wherein a typical operation of a device or system of the present invention is carried out for administration of an eye drop to a patient. For example, the patient holds the device in one hand with a thumb resting on the portion of the actuator that extends radially away from the bottle (actuator shoulder 82). The tip of the actuating head is directed to the eye. The pump mechanism is actuated by applying a force on the actuator to move the actuating head toward the bottle containing the eye drop composition. A drop of the fluid composition is ejected from the tip of actuating head 26 into the eye.
  • A system of the present invention is designed to be easily operated with one hand. For example, in one embodiment, the total length of the device in the unactuated state may be about 3.5-4.5 inches (or about 8.9-11.4 cm). The larger dimension of actuator shoulder 82 may be about 1.5-2 inches (or about 3.8-5 cm). The diameter of the bottle nay be about 1-1.5 inch (or about 2.5-3.8 cm), and the bottle may contain about 10-15 ml of the fluid composition.
  • One factor determining the amount of force required to operate pump 10 is the restoring force of spring 36. Actuator shoulder 82 is sized to accommodate a force applied by a thumb, and thus provides operational benefits especially to patients having limited flexibility.
  • The surface of actuator shoulder 82 on which a thumb rests may be provided with raised ridges or other similar designs to prevent slipping of the thumb. Alternatively, said surface may be formed with a friction enhancing material.
  • Bottle 100, actuator 80, and various parts of pump mechanism 10 may be made of polymeric materials, such as polyethylene (e.g., pharmaceutical-grade high-density polyethylene), polyvinyl chloride, or polyethylene terephthalate.
  • While specific embodiments of the present invention have been described in the foregoing, it will be appreciated by those skilled in the art that many equivalents, modifications, substitutions, and variations may be made thereto without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (3)

1. A hand-operable system for ejecting a fluid composition into an eye, the system comprising: (1) a container having a container opening and containing the fluid composition; (2) a double-acting pump mechanism securely disposed over the container opening; and (3) an actuator that is disposed over, and extends radially outward from, said pump mechanism, for actuating the pump mechanism by applying a force thereon, wherein said pump mechanism comprises a passage for said fluid composition, and said passage is positively sealed off when the application of said force is discontinued.
2. The hand-operable system of claim 1, wherein said actuator extends radially outward from the pump mechanism to form an actuator shoulder that is sized to accommodate a thumb.
3. The hand-operable system of claim 2, wherein the system is sized to be operated with one hand.
US13/018,889 2011-02-01 2011-02-01 Ergonomic hand-operable fluid-dispensing device Active 2032-10-15 US9186690B2 (en)

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US13/018,889 US9186690B2 (en) 2011-02-01 2011-02-01 Ergonomic hand-operable fluid-dispensing device
EP12701401.7A EP2670535A1 (en) 2011-02-01 2012-01-12 Ergonomic hand-operable fluid-dispensing device
PCT/US2012/021053 WO2012106082A1 (en) 2011-02-01 2012-01-12 Ergonomic hand-operable fluid-dispensing device
CA2822691A CA2822691C (en) 2011-02-01 2012-01-12 Ergonomic hand-operable fluid-dispensing device
MX2013007719A MX337227B (en) 2011-02-01 2012-01-12 Ergonomic hand-operable fluid-dispensing device.
CN2012800061767A CN103328111A (en) 2011-02-01 2012-01-12 Ergonomic hand-operable fluid-dispensing device
TW101102286A TWI544939B (en) 2011-02-01 2012-01-19 Ergonomic hand-operable fluid-dispensing device
ARP120100289A AR085098A1 (en) 2011-02-01 2012-01-30 ERGONOMIC FLUID DOSING DEVICE OPERABLE IN MANUAL FORM

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3019804A1 (en) * 2014-04-15 2015-10-16 Thea Lab FLUID OF PACKAGING OF LIQUID
US20150298151A1 (en) * 2012-11-28 2015-10-22 Meadwestvaco Calmar Gmbh Manually operated dispenser for media
US9204994B2 (en) 2010-10-04 2015-12-08 Aptar Radolfzell Gmbh Discharge device
EP2992967A1 (en) * 2014-09-02 2016-03-09 F. Holzer GmbH Medicament dispenser
US20160296958A1 (en) * 2015-04-07 2016-10-13 Eos Products, Llc Liquid dispenser with pump
CN106821591A (en) * 2017-03-09 2017-06-13 浙江大学 A kind of eyedrops bottle of quantified dropping liquid and stabilization based on capacitor type touch switch
WO2017162655A1 (en) * 2016-03-24 2017-09-28 F. Holzer Gmbh Metering pump for a metering device and metering device
US10583038B2 (en) 2015-04-10 2020-03-10 Kedalion Therapeutics Piezoelectric dispenser with replaceable ampoule
US10888454B2 (en) 2017-01-20 2021-01-12 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
US11007116B2 (en) * 2018-07-09 2021-05-18 Kyung Ok YANG Medicant dispenser for the prevention infiltration from bacteria
US11278448B2 (en) 2017-12-08 2022-03-22 Kedalion Therapeutics, Inc. Fluid delivery alignment system
LU102197B1 (en) * 2020-11-12 2022-05-12 Gleixner Holding Gmbh & Co Kg Dispensing device for dispensing a liquid medium, in particular an eye fluid
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US11819453B2 (en) 2015-01-12 2023-11-21 Novartis Ag Micro-droplet delivery device and methods
US11925577B2 (en) 2020-04-17 2024-03-12 Bausch + Lomb Ireland Limted Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
US11938056B2 (en) 2017-06-10 2024-03-26 Eyenovia, Inc. Methods and devices for handling a fluid and delivering the fluid to the eye

Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US180036A (en) * 1876-07-18 Improvement in lubricating attachments for oil-bottles
US185180A (en) * 1876-12-12 Improvement in lubricating - bottles
US1989714A (en) * 1930-09-23 1935-02-05 Statham Noel Self-sealing valve
US3170462A (en) * 1962-01-05 1965-02-23 Merck & Co Inc Aerosol ophthalmic device
US4830284A (en) * 1983-04-28 1989-05-16 Ing. Erich Pfeiffer Gmbh & Co. Kg Atomizing or dosing pump
US4973322A (en) * 1989-07-13 1990-11-27 Jewart Ronald D Eyedropper bottle attachment
US5267986A (en) * 1992-04-06 1993-12-07 Self-Instill & Co., Inc. Cartridge for applying medicament to an eye from a dispenser
US5373972A (en) * 1991-11-15 1994-12-20 Jsp Partners, L.P. Preservative-free sterile fluid dispensing system
US5588564A (en) * 1995-08-21 1996-12-31 Hutson; Clifford L. Eye spray mist dispenser
US5611788A (en) * 1994-07-06 1997-03-18 Marchment; David Eye drop dispenser
US5614172A (en) * 1990-08-29 1997-03-25 Ursapharm Arzneimittel Gmbh Fluid dispenser for germ-free fluid
US5746728A (en) * 1994-10-03 1998-05-05 Py; Daniel Fluid pump without dead volume
US6308867B1 (en) * 1998-09-07 2001-10-30 Ing. Erich Pfeiffer Gmbh Media dispenser
US6336917B1 (en) * 1998-02-04 2002-01-08 Nulli Secundus, Inc. Ocular inspection and eye mist apparatus
US6386397B2 (en) * 1998-08-21 2002-05-14 Pharmacia & Upjohn Company Spray bottle grip
US20020148462A1 (en) * 2001-03-12 2002-10-17 Eric Fugelsang Dual-canister inhaler having a spacer and easy to operate lever mechanism
US20040111070A1 (en) * 2002-12-09 2004-06-10 Hanley Gary L. Device for non-gravity presentation of a liquid droplet
US20040173642A1 (en) * 2003-03-06 2004-09-09 Clifford Julia A. Device for dispensing fluid medicine
US6857427B2 (en) * 2002-09-04 2005-02-22 Ric Investments, Inc. Interactive character for use with an aerosol medication delivery system
US20050161467A1 (en) * 2002-04-26 2005-07-28 Jones Anthony P. Medicament dispenser

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR957218A (en) 1945-08-11 1950-02-17
US4771769A (en) * 1982-12-20 1988-09-20 Schering Corporation Hand held metered spray dispenser
FR2612571B1 (en) 1987-03-17 1992-03-06 Valois PUMP DISPENSER FOR SMALL PRECISE DOSES OF FLUID PRODUCT
EP0378935B1 (en) 1988-12-20 1992-09-23 Societe Technique De Pulverisation (S.T.E.P.) Device to dispense a liquid or cream in droplets having small volumes
CN2076455U (en) * 1990-08-29 1991-05-08 陈易恒 Sprayer
JPH11500646A (en) * 1995-06-07 1999-01-19 オニール，アレクサンダー・ジョージ・ブライアン Patient controlled drug delivery device
FR2762589B1 (en) * 1997-04-28 1999-07-16 Sofab DISTRIBUTION BOTTLE FOR LIQUID, CREAM OR GEL COMPRISING A DEVICE FOR FILTERING THE AIR ENTERING
FR2781772B1 (en) 1998-07-31 2000-10-13 Sofab DISPENSER OF LIQUID PRODUCTS FOR DELIVERY BY SPRAYING
DE10231749B4 (en) 2002-07-13 2004-07-29 Aero Pump GmbH, Zerstäuberpumpen Suction-pressure pump for dispensing a liquid from a container
ITMI20031405A1 (en) * 2003-07-10 2005-01-11 Therapicon Srl MANUAL DEVICE TO INCREASE THE PERFORMANCE OF A CONVENTIONAL SPRAYER.
EP1616629B1 (en) 2004-07-13 2014-04-02 Aptar Radolfzell GmbH Actuation device for a fluid dispenser
US20060047250A1 (en) * 2004-08-30 2006-03-02 Hickingbotham Dyson W Fluid delivery device
FR2882349B1 (en) * 2005-02-21 2007-05-25 Tebro Sa Luxembourgeoise HEAD OF DISTRIBUTION OF FLUID PRODUCT.
JP2007151646A (en) * 2005-12-01 2007-06-21 Shinko Chemical Co Ltd Injection adapter of medicinal solution container
FR2946257B1 (en) 2009-06-03 2015-05-29 Michel Faurie DEVICE FOR ASSISTING THE DELIVERY OF DROPS OF A LIQUID CONTAINED IN A SPRAYER AND SPRAYER EQUIPPED WITH SUCH A DEVICE

Patent Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US180036A (en) * 1876-07-18 Improvement in lubricating attachments for oil-bottles
US185180A (en) * 1876-12-12 Improvement in lubricating - bottles
US1989714A (en) * 1930-09-23 1935-02-05 Statham Noel Self-sealing valve
US3170462A (en) * 1962-01-05 1965-02-23 Merck & Co Inc Aerosol ophthalmic device
US4830284A (en) * 1983-04-28 1989-05-16 Ing. Erich Pfeiffer Gmbh & Co. Kg Atomizing or dosing pump
US4973322A (en) * 1989-07-13 1990-11-27 Jewart Ronald D Eyedropper bottle attachment
US5614172A (en) * 1990-08-29 1997-03-25 Ursapharm Arzneimittel Gmbh Fluid dispenser for germ-free fluid
US5373972A (en) * 1991-11-15 1994-12-20 Jsp Partners, L.P. Preservative-free sterile fluid dispensing system
US5267986A (en) * 1992-04-06 1993-12-07 Self-Instill & Co., Inc. Cartridge for applying medicament to an eye from a dispenser
US5611788A (en) * 1994-07-06 1997-03-18 Marchment; David Eye drop dispenser
US5746728A (en) * 1994-10-03 1998-05-05 Py; Daniel Fluid pump without dead volume
US5588564A (en) * 1995-08-21 1996-12-31 Hutson; Clifford L. Eye spray mist dispenser
US6336917B1 (en) * 1998-02-04 2002-01-08 Nulli Secundus, Inc. Ocular inspection and eye mist apparatus
US6386397B2 (en) * 1998-08-21 2002-05-14 Pharmacia & Upjohn Company Spray bottle grip
US6308867B1 (en) * 1998-09-07 2001-10-30 Ing. Erich Pfeiffer Gmbh Media dispenser
US20020148462A1 (en) * 2001-03-12 2002-10-17 Eric Fugelsang Dual-canister inhaler having a spacer and easy to operate lever mechanism
US20050161467A1 (en) * 2002-04-26 2005-07-28 Jones Anthony P. Medicament dispenser
US6857427B2 (en) * 2002-09-04 2005-02-22 Ric Investments, Inc. Interactive character for use with an aerosol medication delivery system
US20040111070A1 (en) * 2002-12-09 2004-06-10 Hanley Gary L. Device for non-gravity presentation of a liquid droplet
US20040173642A1 (en) * 2003-03-06 2004-09-09 Clifford Julia A. Device for dispensing fluid medicine

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9204994B2 (en) 2010-10-04 2015-12-08 Aptar Radolfzell Gmbh Discharge device
US20150298151A1 (en) * 2012-11-28 2015-10-22 Meadwestvaco Calmar Gmbh Manually operated dispenser for media
US9505016B2 (en) * 2012-11-28 2016-11-29 WestRock Dispensing Systems Hemer GmbH Manually operated dispenser for media
FR3019804A1 (en) * 2014-04-15 2015-10-16 Thea Lab FLUID OF PACKAGING OF LIQUID
EP2992967A1 (en) * 2014-09-02 2016-03-09 F. Holzer GmbH Medicament dispenser
US11819453B2 (en) 2015-01-12 2023-11-21 Novartis Ag Micro-droplet delivery device and methods
US20160296958A1 (en) * 2015-04-07 2016-10-13 Eos Products, Llc Liquid dispenser with pump
US10583038B2 (en) 2015-04-10 2020-03-10 Kedalion Therapeutics Piezoelectric dispenser with replaceable ampoule
RU2733152C1 (en) * 2016-03-24 2020-09-29 Ф. Хольцер Гмбх Dosing pump for dosing device and dosing device
US20190101108A1 (en) * 2016-03-24 2019-04-04 F. Holzer Gmbh Metering pump for a metering device and metering device
WO2017162655A1 (en) * 2016-03-24 2017-09-28 F. Holzer Gmbh Metering pump for a metering device and metering device
US10865779B2 (en) * 2016-03-24 2020-12-15 F. Holzer Gmbh Metering pump for a metering device and metering device
AU2017236368B2 (en) * 2016-03-24 2022-06-02 F. Holzer Gmbh Metering pump for a metering device and metering device
US10888454B2 (en) 2017-01-20 2021-01-12 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
CN106821591A (en) * 2017-03-09 2017-06-13 浙江大学 A kind of eyedrops bottle of quantified dropping liquid and stabilization based on capacitor type touch switch
US11278448B2 (en) 2017-12-08 2022-03-22 Kedalion Therapeutics, Inc. Fluid delivery alignment system
US11007116B2 (en) * 2018-07-09 2021-05-18 Kyung Ok YANG Medicant dispenser for the prevention infiltration from bacteria
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US11925577B2 (en) 2020-04-17 2024-03-12 Bausch + Lomb Ireland Limted Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
LU102197B1 (en) * 2020-11-12 2022-05-12 Gleixner Holding Gmbh & Co Kg Dispensing device for dispensing a liquid medium, in particular an eye fluid

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CA2822691C (en) 2017-01-03
TWI544939B (en) 2016-08-11
AR085098A1 (en) 2013-09-11
WO2012106082A1 (en) 2012-08-09
TW201238617A (en) 2012-10-01
US9186690B2 (en) 2015-11-17
MX337227B (en) 2016-02-18
EP2670535A1 (en) 2013-12-11
CN103328111A (en) 2013-09-25
CA2822691A1 (en) 2012-08-09
MX2013007719A (en) 2013-07-22

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