US20130046209A1 - Systems and methods for improving an outside appearance of skin using ultrasound as an energy source - Google Patents
Systems and methods for improving an outside appearance of skin using ultrasound as an energy source Download PDFInfo
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- US20130046209A1 US20130046209A1 US13/545,954 US201213545954A US2013046209A1 US 20130046209 A1 US20130046209 A1 US 20130046209A1 US 201213545954 A US201213545954 A US 201213545954A US 2013046209 A1 US2013046209 A1 US 2013046209A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0017—Wound healing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0034—Skin treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0039—Ultrasound therapy using microbubbles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0056—Beam shaping elements
- A61N2007/006—Lenses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0073—Ultrasound therapy using multiple frequencies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
- A61N2007/027—Localised ultrasound hyperthermia with multiple foci created simultaneously
Definitions
- ultrasound energy can be applied to treat tissue or perform traditionally invasive procedures in a non-invasive manner.
- the application of ultrasound energy provides both thermal and/or mechanical effects that help treat certain ailments such as acne and enable many traditional invasive procedures to be performed non-invasively.
- ultrasound devices typically affect a specific portion of the tissue at a certain depth within the region of interest based upon the configuration of the particular ultrasound device.
- an ultrasound device might be configured to affect an area five millimeters below the surface of the skin.
- the tissue from the surface of the skin to the depth of five millimeters is spared and not treated by the ultrasound energy. Sparing these intervening spaces of tissue hinders the overall beneficial effect of ultrasound as treatment of this intervening tissue increases ultrasound treatment's overall efficacy. Accordingly, new approaches of cosmetic enhancement of skin are needed, which are rapid and non-invasive.
- ultrasound energy can be focused, unfocused or defocused and can be applied to a region of interest containing subcutaneous tissue below a surface to achieve a cosmetic effect.
- the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface.
- the improving the appearance of the targeted portion of the skin surface comprises at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
- the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface.
- the system can further comprise a hand-held probe comprising: an ultrasound transducer; an indicator display; at least one input/output control; a position sensor; and a rechargeable battery configured to power the hand-held probe.
- the system can further comprise a controller configured to control the hand-held probe and a wireless interface configured to couple communication between the controller and the hand-held probe.
- the controller is at least one of a personal data assistant, a cell phone, an iPhone, an iPad, a computer, a laptop, and a netbook.
- the transducer is configured as a 2 dimensional linear array.
- FIG. 1 is a flow chart illustrating methods of cosmetic enhancement, according to various non-limiting embodiments
- FIG. 2 is a flow chart illustrating methods according to various non-limiting embodiments
- FIG. 3 is a cross sectional view illustrating ultrasound energy directed to various subcutaneous tissue layers below a surface, according to various non-limiting embodiments
- FIG. 4 is a cross sectional view illustrating ultrasound energy directed to two targets in subcutaneous tissue below a surface, according to various non-limiting embodiments
- FIG. 5 is a cross sectional view illustrating a conformal region of elevated temperature in subcutaneous tissue, according to various non-limiting embodiments
- FIG. 6 is a cross sectional view illustrating a conformal region of elevated temperature in various layers of subcutaneous tissue, according to various non-limiting embodiments
- FIG. 7 is a cross sectional view illustrating conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue, according to various non-limiting embodiments
- FIG. 8 is a prospective view illustrating conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue, according to various non-limiting embodiments
- FIG. 9 is a cross sectional view illustrating conformal region of elevated temperature and second conformal region of elevated temperature in various layers of subcutaneous tissue, according to various non-limiting embodiments.
- FIGS. 10 A-B are a cross sectional views illustrating conformal region of elevated temperature and second conformal region of elevated temperature in soft tissue, according to various non-limiting embodiments;
- FIGS. 11 A-B are a cross sectional views illustrating conformal region of elevated temperature and second conformal region of elevated temperature in soft tissue, according to various non-limiting embodiments;
- FIG. 12 is a cross sectional view illustrating a plurality of conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue, according to various non-limiting embodiments.
- FIG. 13 is a cross sectional view illustrating a hand held probe, according to various non-limiting embodiments.
- the phrase “at least one of A, B, and C” should be construed to mean a logical (A or B or C), using a non-exclusive logical “or.”
- the phrase “A, 3 and/or C” should be construed to mean (A, B, and C) or alternatively (A or B or C), using a non-exclusive logical “or.” It should be understood that steps within a method may be executed in different order without altering the principles of the present disclosure.
- various embodiments may be described herein in terms of various functional components and processing steps. It should be appreciated that such components and steps may be realized by any number of hardware components configured to perform the specified functions.
- various embodiments may employ various medical treatment devices, visual imaging and display devices, input terminals and the like, which may carry out a variety of functions under the control of one or more control systems or other control devices.
- the embodiments may be practiced in any number of medical contexts and that the various embodiments relating to a method and system for acoustic tissue treatment as described herein are merely indicative of exemplary applications for the invention.
- the principles, features and methods discussed may be applied to any medical application.
- various aspects of the various embodiments may be suitably applied to cosmetic applications.
- some of the embodiments may be applied to cosmetic enhancement of skin and/or various subcutaneous tissue layers.
- methods and systems useful for cosmetic rejuvenation of face and body are provided herein.
- the methods and systems provided herein are noninvasive, for example, no cutting or injecting into the skin is required.
- Cosmetic rejuvenation of the face and/or body using the methods and systems provided herein minimize recover time and may in some cases eliminate downtime for recovery. Further cosmetic rejuvenation using the methods and systems provided herein minimize discomfort to a patient having such a rejuvenation procedure.
- a hand-held extracorporeal apparatus which emits controlled ultrasound energy into layers of the skin to create a conformal region of elevated temperature in tissue of the skin.
- a system useful for cosmetic rejuvenation of the face and/or body is in a handheld format which may include a rechargeable power supply.
- a cosmetic enhancement can be a procedure but not limited to procedures that are used to improve or change the appearance of a nose, eyes, eyebrows and/or other facial features, or to improve or change the appearance and/or the texture and/or the elasticity of skin, or to improve or change the appearance of a mark or scar on a skin surface, or to improve or change the appearance and/or the content of fat near a skin surface, or the targeting of a gland to improve or change the appearance a portion of the body.
- cosmetic enhancement is a non-surgical and non-invasive procedure.
- cosmetic enhancement provides rejuvenation to at least one portion of the body.
- methods of cosmetic enhancement can increase elasticity of skin by thinning a dermis layer, thereby rejuvenating a portion of skin.
- methods of cosmetic enhancement can stimulate initiation of internal body resources for the purpose of repairing an injury and/or cell defienticy.
- the method can comprise locating a targeted portion of skin surface; targeting a region of interest comprising the targeted portion of the skin surface and subcutaneous tissue below the skin surface; delivering ultrasound energy to the region of interest; producing an effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface.
- the method can further comprise imaging the subcutaneous tissue below the skin surface. In some embodiments, the method can further comprise administering a medicant to the region of interest. In some embodiments, the method can further comprise activating the medicant in the region of interest with the ultrasound energy at the same frequency or a different frequency.
- the effect is a cosmetic effect.
- the cosmetic effect is at least one of increasing skin elasticity/tighten skin, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, reducing fat, reducing cellulite, treating and/or preventing acne, treating hyperhidrosis, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, treating of soft tissue in the region of interest, rejuvenating skin, increasing skin elasticity, increasing collagen in tissue, smoothing of the texture of skin, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, lifting of skin, body sculpting, generating new tissue in the subcutaneous tissue, and combinations thereof.
- the improving the appearance of the targeted portion of the skin surface comprises at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
- the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface.
- the method can further comprise delivering a medicant to the subcutaneous tissue below the skin surface. In some embodiments, the method can further comprise comprising activating the medicant in the region of interest with the ultrasound energy at the same frequency or a different frequency. In some embodiments, the method can further comprise delivering a cosmeceutical to the subcutaneous tissue below the skin surface.
- the method can further comprise delivering a secondary energy to the subcutaneous tissue below the skin surface.
- the secondary energy is a photon-based energy.
- the secondary energy is radio frequency based energy.
- the biological effect is at least one of stimulating or increase an amount of heat shock proteins, cause white blood cells to promote healing of a portion of the subcutaneous tissue, accelerating ta wound healing cascade in the subcutaneous tissue, increasing the blood perfusion in the subcutaneous tissue, encouraging collagen growth in the subcutaneous tissue, increasing the liberation of cytokines within the subcutaneous layer, peaking inflammation in the subcutaneous tissue, partially shrinking collagen in a portion of the subcutaneous tissue, denaturing of proteins in the subcutaneous tissue, and combinations thereof.
- the biological effect is at least one of creating immediate or delayed cell death in the subcutaneous tissue, collagen remodeling in the subcutaneous tissue, disrupting or modifying of biochemical cascades in at least one of the skin surface and the subcutaneous tissue, producing new collagen in the subcutaneous tissue, stimulating cell growth in the subcutaneous tissue, stimulating angiogenesis, stimulating a cell permeability response, enhancing delivery of medicants to in the subcutaneous tissue, and combinations thereof.
- the improving the appearance of the targeted portion of the skin surface comprises at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
- the system can further comprise a hand-held probe comprising: an ultrasound transducer; an indicator display; at least one input/output control; a position sensor; and a rechargeable battery configured to power the hand-held probe.
- the system can further comprise a controller configured to control the hand-held probe and a wireless interface configured to couple communication between the controller and the hand-held probe.
- the controller is at least one of a personal data assistant, a cell phone, an iPhone, an iPad, a computer, a laptop, and a netbook.
- the transducer is configured as a 2 dimensional linear array.
- the system and the related method of the present invention apply ultrasound energy to a region of interest at the surface of the patient's skin and ultrasound energy travels from the surface to a location within the region of interest and treats all the tissue within the region of interest with a combined energy profile without sparing any of such tissue.
- the ultrasound transducer is configured to simultaneously create a first conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue.
- the first conformal region of elevated temperature and second conformal region of elevated temperature intersect in the subcutaneous tissue.
- the first conformal region of elevated temperature and second conformal region of elevated temperature are positioned perpendicular to each other in the subcutaneous tissue.
- the method can comprise creating a conformal region of elevated temperature; treating a surface and subsurface of skin simultaneously; creating a transitional biological effect on the surface of the skin without causing cell death, a scar, or permanent damage to the surface of the skin; creating a thermal effect to the subsurface of the skin; and initiating a permanent biological effect to the subsurface of the skin.
- the method can further comprise creating an optically visible effect on the surface of the skin.
- the transitional biological effect can be one of erythema, edema, and a transitional coagulative point.
- the optically visible effect on the surface of the skin can be at least one of at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
- the permanent biological effect can be at least one of is at least one of stimulating or increase an amount of heat shock proteins, cause white blood cells to promote healing of a portion of the subcutaneous tissue, accelerating ta wound healing cascade in the subcutaneous tissue, increasing the blood perfusion in the subcutaneous tissue, encouraging collagen growth in the subcutaneous tissue, increasing the liberation of cytokines within the subcutaneous layer, peaking inflammation in the subcutaneous tissue, partially shrinking collagen in a portion of the subcutaneous tissue, denaturing of proteins in the subcutaneous tissue, and combinations thereof.
- the permanent biological effect is at least one of creating immediate or delayed cell death in the subcutaneous tissue, collagen remodeling in the subcutaneous tissue, disrupting or modifying of biochemical cascades in at least one of the skin surface and the subcutaneous tissue, producing new collagen in the subcutaneous tissue, stimulating cell growth in the subcutaneous tissue, stimulating angiogenesis, stimulating a cell permeability response, enhancing delivery of medicants to in the subcutaneous tissue, and combinations thereof.
- Step 10 is identifying a targeted skin surface, which may be located anywhere on the body, such as, for example, in any of the following: face, neck, hands, arms, legs, buttocks, and combinations thereof.
- Step 12 is targeting a region of interest (“ROI”).
- the ROI can be located in subcutaneous tissue below the targeted skin surface, which can be anywhere in the body, such as, those listed previously.
- the subcutaneous tissue can comprise any or all of the following tissues: an epidermal layer, a dermal layer, a fat layer, a SMAS layer, and a muscle layer.
- step 22 is imaging subcutaneous tissue below the targeted skin surface can be between steps 10 and 12 or can be substantially simultaneous with or be part of step 12 .
- step 14 is directing ultrasound energy to ROI.
- the ultrasound energy may be focused, defocused, or unfocused.
- the ultrasound sound energy can be weakly focused.
- the ultrasound energy can be directed to the subcutaneous tissue layer below the targeted skin surface.
- the ultrasound energy may be streaming.
- the ultrasound energy may be directed to a first depth and then directed to a second depth.
- the ultrasound energy may force a pressure gradient in the subcutaneous tissue layer below the targeted skin surface.
- the ultrasound energy may be a first ultrasound energy effect, which comprises an ablative or a hemostatic effect, and a second ultrasound energy effect, which comprises at least one of non-thermal streaming, hydrodynamic, diathermic, and resonance induced tissue effects. Directing ultrasound energy to the ROI is a non-invasive technique.
- the targeted skin surface and the layers above a target point in the subcutaneous layer are spared from injury.
- the targeted skin surface and the layers above a target point in the subcutaneous layer are heated to a 10° C. to 15° C. above the tissue's natural state. Such treatment does not require an incision in order to reach the subcutaneous tissue layer below the targeted skin surface to enhance the targeted skin surface.
- the ultrasound energy level is in a range of about 0.1 joules to about 500 joules in order to create an ablative lesion.
- the ultrasound energy 108 level can be in a range of from about 0.1 joules to about 100 joules, or from about 1 joules to about 50 joules, or from about 0.1 joules to about 10 joules, or from about 50 joules to about 100 joules, or from about 100 joules to about 500 joules, or from about 50 joules to about 250 joules.
- the amount of time ultrasound energy is applied at these levels to create a lesion varies in the range from approximately 1 millisecond to several minutes.
- a range can be from about 1 millisecond to about 5 minutes, or from about 1 millisecond to about 1 minute, or from about 1 millisecond to about 30 seconds, or from about 1 millisecond to about 10 seconds, or from about 1 millisecond to about 1 second, or from about 1 millisecond to about 0.1 seconds, or about 0.1 seconds to about 10 seconds, or about 0.1 seconds to about 1 second, or from about 1 millisecond to about 200 milliseconds, or from about 1 millisecond to about 0.5 seconds.
- the frequency of the ultrasound energy can be in a range from about 0.1 MHz to about 100 MHz, or from about 0.1 MHz to about 50 MHz, or from about 1 MHz to about 50 MHz or about 0.1 MHz to about 30 MHz, or from about 10 MHz to about 30 MHz, or from about 0.1 MHz to about 20 MHz, or from about 1 MHz to about 20 MHz, or from about 20 MHz to about 30 MHz.
- the frequency of the ultrasound energy can be in a range from about 1 MHz to about 12 MHz, or from about 5 MHz to about 15 MHz, or from about 2 MHz to about 12 MHz or from about 3 MHz to about 7 MHz.
- the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 0 mm to about 150 mm, or from about 0 mm to about 100 mm, or from about 0 mm to about 50 mm, or from about 0 mm to about 30 mm, or from about 0 mm to about 20 mm, or from about 0 mm to about 10 mm, or from about 0 mm to about 5 mm.
- the ultrasound energy can be emitted to depths below a skin surface in a range from about 5 mm to about 150 mm, or from about 5 mm to about 100 mm, or from about 5 mm to about 50 mm, or from about 5 mm to about 30 mm, or from about 5 mm to about 20 mm, or from about 5 mm to about 10 mm.
- the ultrasound energy can be emitted to depths below a skin surface in a range from about 10 mm to about 150 mm, or from about 10 mm to about 100 mm, or from about 10 mm to about 50 mm, or from about mm to about 30 mm, or from about 10 mm to about 20 mm, or from about 0 mm to about 10 mm.
- the ultrasound energy can be emitted to depths at or below a skin surface in the range from about 20 mm to about 150 mm, or from about 20 mm to about 100 mm, or from about 20 mm to about 50 mm, or from about 20 mm to about 30 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 30 mm to about 150 mm, or from about 30 mm to about 100 mm, or from about 30 mm to about 50 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 50 mm to about 150 mm, or from about 50 mm to about 100 mm.
- the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 20 mm to about 60 mm, or from about 40 mm to about 80 mm, or from about 10 mm to about 40 mm, or from about 5 mm to about 40 mm, or from about 0 mm to about 40 nm, or from about 10 mm to about 30 mm, or from about 5 mm to about 30 mm, or from about 0 mm to about 30 mm.
- the ultrasound energy may be emitted at various energy levels, such as for example, the energy levels described herein. Further, the amount of time ultrasound energy is applied at these levels for various time ranges, such as for example, the ranges of time described herein.
- the frequency of the ultrasound energy is in various frequency ranges, such as for example, the frequency ranges described herein.
- the ultrasound energy can be emitted to various depths below a targeted skin surface, such as for example, the depths described herein.
- the ultrasound energy may coagulate a portion of the subcutaneous tissue layer below the targeted skin surface.
- the ultrasound energy may score a portion of subcutaneous tissue layer below the targeted skin surface.
- step 24 which is administering a medicant and/or cosmeceutical to the ROI, can be between steps 12 and 14 .
- the medicant and/or cosmeceutical can be any chemical or naturally occurring substance that can assist in cosmetic enhancement.
- the medicant and/or cosmeceutical can be but not limited to a pharmaceutical, a drug, a medication, a nutriceutical, an herb, a vitamin, a cosmetic, an amino acid, a collagen derivative, a holistic mixture, and combinations thereof.
- the medicant and/or cosmeceutical can be administered by applying it to the skin above the ROI.
- the medicant and/or cosmeceutical can be administered to the circulatory system.
- the medicant and/or cosmeceutical can be in the blood stream and can be activated or moved to the ROI by the ultrasound energy.
- the medicant and/or cosmeceutical can be administered by injection into or near the ROI. Any naturally occurring proteins, stem cells, growth factors and the like can be used as medicant and/or cosmeceutical in accordance to various embodiments.
- a medicant and/or cosmeceutical can be mixed in a coupling gel or can be used as a coupling gel.
- Step 16 is producing a cosmetic effect in the ROI.
- a cosmetic effect can be increase skin elasticity/tighten skin.
- a cosmetic effect can be reducing skin oiliness.
- a cosmetic effect can be reducing skin pore size/smooth skin texture.
- a cosmetic effect can be reducing hyperpigmentation.
- a cosmetic effect can be reducing fat and/or cellulite.
- a cosmetic effect can be treating and/or preventing acne.
- a cosmetic effect can be treating hyperhidrosis.
- a cosmetic effect can be reducing an appearance of spider veins and/or rosacea.
- a cosmetic effect can be reducing an appearance of scars.
- a cosmetic effect can be reducing an appearance of stretch marks.
- a cosmetic effect can be treatment of soft tissue.
- a cosmetic effect can be rejuvenation of skin.
- a cosmetic effect can be increasing skin elasticity.
- a cosmetic effect can be increasing collagen in tissue.
- a cosmetic effect can be a smoothing of the texture of skin.
- a cosmetic effect can be a tightening of sagging sink.
- a cosmetic effect may be the rejuvenation of photoaged skin.
- a cosmetic effect can be increasing a thickness of a dermal layer.
- a cosmetic effect can be a reduction of wrinkle on a skin surface.
- a cosmetic effect can be a lifting of skin, for example, a facelift, a neck lift, a brow lift, and/or a jowl lift.
- a cosmetic effect can be body sculpting.
- a cosmetic effect can be generating new tissue in the subcutaneous layer.
- a cosmetic effect can be synergetic with the medicant and/or cosmeceutical administered to ROI in steps 24 and/or 26 . Cosmetic effects can be combined.
- a cosmetic effect can be produced by a biological effect that initiated or stimulated by the ultrasound energy.
- a biological effect can be stimulating or increase an amount of heat shock proteins.
- Such a biological effect can cause white blood cells to promote healing of a portion of the subcutaneous layer in the ROI.
- a biological effect can be to restart or increase the wound healing cascade at the injury location.
- a biological effect can be increasing the blood perfusion to the injury location.
- a biological effect can be encouraging collagen growth.
- a biological effect may increase the liberation of cytokines and may produce reactive changes within the subcutaneous layer.
- a biological effect may by peaking inflammation in the ROI.
- a biological effect may at least partially shrinking collagen portion of soft tissue.
- a biological effect may be denaturing of proteins in the ROI.
- a biological effect may be creating immediate or delayed cell death (apoptosis) in the ROI.
- a biological effect may be collagen remodeling in the ROI.
- a biological effect may be the disruption or modification of biochemical cascades.
- a biological effect may be the production of new collagen.
- a biological effect may a stimulation of cell growth in the ROI.
- a biological effect may be angiogenesis.
- a biological effect may a cell permeability response.
- a biological effect may be an enhanced delivery of medicants to soft tissue.
- ultrasound energy is deposited in the subcutaneous layer changes at least one of concentration and activity of inflammatory mediators (TNF-A, IL-1) as well as growth factors (TGF-B1, TGF-B3) below the targeted skin surface.
- TNF-A inflammatory mediators
- TGF-B1, TGF-B3 growth factors
- step 26 which is administering medicant and/or cosmeceutical to ROI, can be between steps 14 and 16 or can be substantially simultaneous with or be part of step 16 .
- the medicant and/or cosmeceutical useful in step 26 are essentially the same as those discussed for step 24 .
- ultrasound energy is deposited, which can stimulate a change in at least one of concentration and activity of one or more of the following: Adrenomedullin (AM), Autocrine motility factor, Bone morphogenetic proteins (BMPs), Brain-derived neurotrophic factor (BDNF), Epidermal growth factor (EGF), Erythropoietin (EPO), Fibroblast growth factor (FGF), Glial cell line-derived neurotrophic factor (GDNF), Granulocyte colony-stimulating factor (G-CSF), Granulocyte macrophage colony-stimulating factor (GM-CSF), Growth differentiation factor-9 (GDF9), Hepatocyte growth factor (HGF), Hepatoma-derived growth factor (HDGF), Insulin-like growth factor (NGF), Migration-stimulating factor, Myostatin (GDF-8), Nerve growth factor (NGF) and other neurotrophins, Platelet-derived growth factor (PDGF), Thrombopoietin (TPO), Transforming growth factor alpha
- medicants can include a drug, a medicine, or a protein, and combinations thereof.
- Medicants can also include adsorbent chemicals, such as zeolites, and other hemostatic agents are used in sealing severe injuries quickly.
- Thrombin and fibrin glue are used surgically to treat bleeding and to thrombose aneurysms.
- Medicants can include Desmopressin is used to improve platelet function by activating arginine vasopressin receptor 1 A.
- Medicants can include coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in patients with impaired coagulation factor synthesis or increased consumption.
- Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly-used coagulation factor products.
- Recombinant activated human factor VII can be used in the treatment of major bleeding.
- Medicants can include tranexamic acid and aminocaproic acid, can inhibit fibrinolysis, and lead to a de facto reduced bleeding rate.
- medicants can include steroids like the glucocorticoid cortisol.
- step 25 which is directing secondary energy to the ROT can be substantially simultaneous with or be part of step 16 .
- step 25 can be administered at least one of before and after step 16 .
- Step 25 can be alternated with step 16 , which can create a pulse of two different energy emissions to the ROI.
- step 25 which is directing secondary energy to the ROI can be substantially simultaneous with or be part of step 16 .
- step 25 can be administered at least one of before and after step 16 .
- Step 25 can be alternated with step 16 , which can create a pulse of two different energy emissions to the ROI.
- Secondary energy can be provided by a laser source, or an intense pulsed light source, or a light emitting diode, or a radio frequency, or a plasma source, or a magnetic resonance source, or a mechanical energy source, or any other photon-based energy source.
- Secondary energy can be provided by any appropriate energy source now known or created in the future. More than one secondary energy source may be used for step 25 .
- various embodiments provide energy, which may be a first energy and a second energy.
- a first energy may be followed by a second energy either immediately or after a delay period.
- a first energy and a second energy can be delivered simultaneously.
- the first energy and the second energy is ultrasound energy.
- the first energy is ultrasound and the second energy is generated by one of a laser, an intense pulsed light, a light emitting diode, a radiofrequency generator, photon-based energy source, plasma source, a magnetic resonance source, or a mechanical energy source, such as for example, pressure, either positive or negative.
- energy may be a first energy, a second energy, and a third energy, emitted simultaneously or with a time delay or a combination thereof.
- energy may be a first energy, a second energy, a third energy, and an nth energy, emitted simultaneously or with a time delay or a combination thereof.
- Any of the a first energy, a second energy, a third energy, and a nth may be generated by at least one of a laser, an intense pulsed light, a light emitting diode, a radiofrequency generator, an acoustic source, photon-based energy source, plasma source, a magnetic resonance source, and/or a mechanical energy source.
- Step 20 is cosmetically enhancing the targeted skin surface.
- step 30 is determining results. If the results of step 30 are acceptable within the parameters of the treatment then Yes direction 34 is followed to step 20 . If the results of step 30 are not acceptable within the parameters of the treatment then No direction 32 is followed back to step 12 . Further examples and variations of treatment method 100 are discussed herein.
- method 100 may be used with an extracorporeal, non-invasive procedure.
- temperature may increase within ROI may range from approximately 10° C. to about 15° C.
- Other bio-effects to target tissue can include heating, cavitation, streaming, or vibro-accoustic stimulation, and combinations thereof.
- ultrasound probe is coupled directly to ROI, as opposed to targeted skin surface 104 , to affect the subcutaneous tissue.
- Step 50 is identifying a skin surface.
- the skin surface can be located anywhere on the body. However, the skin surface may be located on the face and/or neck.
- the skin surface contains a defect or other undesirable characteristic that is to be cosmetically enhanced or rejuvenated.
- the defect or other undesirable characteristic may be, for example, but not limited to a wrinkle, oiliness, pore size, rough skin texture, sun spots, liver spots, sagging skin, lack of glow, a scar, a stretch mark, a blemish, and the like.
- Step 60 is directing ultrasound energy into tissue below the skin surface.
- the ultrasound energy may be unfocused and deposited in a volume that spans from the skin surface into one or more of subcutaneous tissue below.
- the ultrasound energy can have any of the characteristics as described herein.
- the ultrasound energy can be controlled using spatial parameters.
- the ultrasound energy can be controlled using temporal parameters.
- the ultrasound energy can be controlled using a combination of temporal parameters and spatial parameters. Also, depending at least in part upon the specific bio-effect and tissue targeted, temperature of the subcutaneous tissue may increase within ROI may range from approximately 10° C. to about 15° C.
- step 55 may be implemented, which is coupling a medicant or cosmeceutical to the skin surface. If step 55 is implemented, step 65 can be employed which is driving the medicant or cosmeceutical in to the subcutaneous layer below the skin surface. The medicant or cosmeceutical may be driven into the subcutaneous layer using the ultrasound energy of step 60 or an alternate frequency of ultrasound energy.
- step 67 can be employed, which is directing a second energy below the skin surface.
- the second energy can be a second ultrasound energy having different characteristics than the ultrasound energy in step 60 .
- the second energy can be provided by a laser source, or an IPL source, or a radio frequency, or a plasma source, or a magnetic resonance source.
- Secondary energy can be provided by any appropriate energy source now known or created in the future. More than one secondary energy source may be used for step 67
- Step 70 is producing a bio-effect in tissue below the skin surface.
- a biological effect can be stimulating or increase an amount of heat shock proteins. Such a biological effect can cause white blood cells to promote healing of a portion of the subcutaneous layer in the ROI.
- a biological effect can be to restart or increase the wound healing cascade at the injury location.
- a biological effect can be increasing the blood perfusion to the injury location.
- a biological effect can be encouraging collagen growth.
- a biological effect may increase the liberation of cytokines and may produce reactive changes within the subcutaneous layer.
- a biological effect may by peaking inflammation in the ROI.
- a biological effect may at least partially shrinking collagen portion of soft tissue.
- a biological effect may be denaturing of proteins in the ROI.
- a biological effect may be creating immediate or delayed cell death (apoptosis) in the ROI.
- a biological effect may be collagen remodeling in the ROI.
- a biological effect may be the disruption or modification of biochemical cascades.
- a biological effect may be the production of new collagen.
- a biological effect may a stimulation of cell growth in the ROI.
- a biological effect may be angiogenesis.
- a biological effect may a cell permeability response.
- a biological effect may be an enhanced delivery of medicants to soft tissue.
- Step 80 is improving an appearance of the skin surface.
- This can be a cosmetic effect.
- the improving an appearance of the skin surface can be an increase in skin elasticity.
- the improving an appearance of the skin surface can be reducing skin oiliness.
- the improving an appearance of the skin surface can be reducing skin pore size.
- the improving an appearance of the skin surface can be smoothing skin texture.
- the improving an appearance of the skin surface can be reducing hyperpigmentation.
- the improving an appearance of the skin surface can be treating and/or preventing acne.
- the improving an appearance of the skin surface can be reducing a blemish.
- the improving an appearance of the skin surface can be reducing an appearance of spider veins and/or rosacea.
- the improving an appearance of the skin surface can be reducing an appearance of scars.
- the improving an appearance of the skin surface can be reducing an appearance of stretch marks.
- the improving an appearance of the skin surface can be rejuvenation of skin.
- the improving an appearance of the skin surface can be increasing collagen in tissue.
- the improving an appearance of the skin surface can be a tightening of sagging sink.
- the improving an appearance of the skin surface can be the rejuvenation of photoaged skin.
- the improving an appearance of the skin surface can be increasing a thickness of a dermal layer.
- the improving an appearance of the skin surface can be a reduction of wrinkle on a skin surface.
- the improving an appearance of the skin surface can be generating new tissue in the subcutaneous layer.
- the improving an appearance of the skin surface can be synergetic with the medicant and/or cosmeceutical administered to ROI in steps 55 and 65 .
- ultrasound energy propagates as a wave with relatively little scattering, over depths up to many centimeters in tissue depending on the ultrasound frequency.
- the focal spot size achievable with any propagating wave energy depends on wavelength.
- Ultrasound wavelength is equal to the acoustic velocity divided by the ultrasound frequency.
- Attenuation (absorption, mainly) of ultrasound by tissue also depends on frequency.
- Shaped conformal distribution of elevated temperature can be created through adjustment of the strength, depth, and type of focusing, energy levels and timing cadence.
- focused ultrasound can be used to create precise arrays of microscopic thermal ablation zones.
- Ultrasound energy 120 can produce an array of ablation zones deep into the layers of the soft tissue. Detection of changes in the reflection of ultrasound energy can be used for feedback control to detect a desired effect on the tissue and used to control the exposure intensity, time, and/or position.
- ultrasound probe 105 is configured with the ability to controllably produce conformal distribution of elevated temperature in soft tissue within ROI 115 through precise spatial and temporal control of acoustic energy deposition, i.e., control of ultrasound probe 105 is confined within selected time and space parameters, with such control being independent of the tissue.
- the ultrasound energy 120 can be controlled using spatial parameters.
- the ultrasound energy 120 can be controlled using temporal parameters.
- the ultrasound energy 120 can be controlled using a combination of temporal parameters and spatial parameters.
- control system and ultrasound probe 105 can be configured for spatial control of ultrasound energy 120 by controlling the manner of distribution of the ultrasound energy 120 .
- spatial control may be realized through selection of the type of one or more transducer configurations insonifying ROI 115 , selection of the placement and location of ultrasound probe 105 for delivery of ultrasound energy 120 relative to ROI 115 e.g., ultrasound probe 105 being configured for scanning over part or whole of ROI 115 to produce contiguous thermal injury having a particular orientation or otherwise change in distance from ROI 115 , and/or control of other environment parameters, e.g., the temperature at the acoustic coupling interface can be controlled, and/or the coupling of ultrasound probe 105 to tissue.
- Other spatial control can include but are not limited to geometry configuration of ultrasound probe 105 or transducer assembly, lens, variable focusing devices, variable focusing lens, stand-offs, movement of ultrasound probe, in any of six degrees of motion, transducer backing, matching layers, number of transduction elements in transducer, number of electrodes, or combinations thereof.
- control system and ultrasound probe 105 can also be configured for temporal control, such as through adjustment and optimization of drive amplitude levels, frequency, waveform selections, e.g., the types of pulses, bursts or continuous waveforms, and timing sequences and other energy drive characteristics to control thermal ablation of tissue.
- Other temporal control can include but are not limited to full power burst of energy, shape of burst, timing of energy bursts, such as, pulse rate duration, continuous, delays, etc., change of frequency of burst, burst amplitude, phase, apodization, energy level, or combinations thereof.
- the spatial and/or temporal control can also be facilitated through open-loop and closed-loop feedback arrangements, such as through the monitoring of various spatial and temporal characteristics.
- control of acoustical energy within six degrees of freedom e.g., spatially within the X, Y and Z domain, as well as the axis of rotation within the XY, YZ and XZ domains, can be suitably achieved to generate conformal distribution of elevated temperature of variable shape, size and orientation.
- ultrasound probe 105 can enable the regions of elevated temperature possess arbitrary shape and size and allow the tissue to be heated in a controlled manner.
- Ultrasound probe 105 emits ultrasound energy 120 in ROI 115 .
- ultrasound probe 105 is capable of emitting ultrasound energy 120 at variable depths in ROI 115 , such as, for example, the depths described herein.
- Ultrasound probe 105 is capable of emitting ultrasound energy as a single frequency, variable frequencies, or a plurality of frequencies, such as, for example, the frequency ranges described herein.
- Ultrasound probe 105 is capable of emitting ultrasound energy that is weakly focused.
- Ultrasound probe 105 is capable of emitting ultrasound energy 120 for variable time periods or to pulse the emission over time, such as, for example, those time intervals described herein. Ultrasound probe 105 is capable of providing various energy levels of ultrasound energy, such as, for example, the energy levels described herein.
- Ultrasound probe 105 may be individual hand-held device, or may be part of a treatment system.
- the ultrasound probe 105 can provide both ultrasound energy and imaging ultrasound energy. However, ultrasound probe 105 may provide only ultrasound energy.
- Ultrasound probe 105 may comprise a therapeutic transducer and a separate imaging transducer.
- Ultrasound probe 105 may comprise a transducer or a transducer array capable of both cosmetic rejuvenation and imaging applications. According an alternative embodiment, ultrasound probe 105 is coupled directly to one of the tissue layers, as opposed to targeted skin surface 104 to treat the tissue layer.
- ultrasound probe 105 may be used for method 100 or method 150 .
- method 100 or method 150 can be implemented using any or all of the elements illustrated in FIG. 3 .
- at least a portion of method 100 or a variation of method 100 can be implemented using any or all of the elements illustrated in FIG. 3 .
- at least a portion of method 150 or a variation of method 150 can be implemented using any or all of the elements illustrated in FIG. 3 .
- Transduction element 125 B comprises first transduction element 121 and second transduction element 122 .
- first transduction element 121 and second transduction element 122 can have the same focus, which can be mechanical focus, electronic focus, or combinations thereof.
- first transduction element 121 and second transduction element 122 can have different focal points.
- first transduction element 121 and second transduction element 122 can be multiple elements of the same therapy transducer, sectioned for different f-numbers.
- first transduction element 121 is operable to focus ultrasound energy 148 to target zone 142 and second transduction element 122 is operable to focus ultrasound energy 108 to second target zone 142 A.
- first transduction element 121 and second transduction element 122 may be controlled in a combination of different frequencies, different time periods, and different power levels to focus ultrasound energy 148 to at least one of target zone 142 and second target zone 142 A.
- Annular array 131 can be controlled to weakly focused ultrasound energy 133 into subcutaneous layer 127 .
- the weakly focused ultrasound energy 133 is controlled to create a conformal region 133 of elevated temperature in the subcutaneous layer 127 .
- the conformal region 133 of elevated temperature can be directed to one or more layers of skin or one or more layers of subcutaneous tissue 127 .
- the conformal region 133 of elevated temperature may be directed to span from skin surface 104 to the epidermal layer 102 .
- the conformal region 133 of elevated temperature may be directed to span from skin surface 104 , through the epidermal layer 102 , to at least a portion of the dermal layer 106 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 , epidermal layer 102 , dermis layer 106 , and fat layer 108 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 , epidermal layer 102 , dermis layer 106 , fat layer 108 , and SMAS layer 110 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 , epidermal layer 102 , dermis layer 106 , fat layer 108 , and SMAS layer 110 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 , epidermal layer 102 , dermis layer 106 , fat layer 108 , SMAS layer 110 and muscle layer 112 .
- the conformal region 133 of elevated temperature may include epidermal layer 102 , dermis layer 106 , fat layer 108 , SMAS layer 110 and muscle layer 112 .
- the conformal region 133 of elevated temperature may include dermis layer 106 , fat layer 108 , SMAS layer 110 and muscle layer 112 .
- the conformal region 133 of elevated temperature may include SMAS layer 110 and muscle layer 112 .
- the conformal region 133 of elevated temperature may include the muscle layer 112 .
- the conformal region 133 of elevated temperature may include epidermal layer 102 , dermis layer 106 , fat layer 108 , and SMAS layer 110 .
- the conformal region 133 of elevated temperature may include dermis layer 106 , fat layer 108 , and SMAS layer 110 .
- the conformal region 133 of elevated temperature may include fat layer 108 , and SMAS layer 110 .
- the conformal region 133 of elevated temperature may include SMAS layer 110 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 , epidermal layer 102 , dermis layer 106 , and fat layer 108 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 , epidermal layer 102 , dermis layer 106 , and fat layer 108 .
- the conformal region 133 of elevated temperature may include dermis layer 106 , and fat layer 108 .
- the conformal region 133 of elevated temperature may include dermis the fat layer 108 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 , epidermal layer 102 , and dermis layer 106 .
- the conformal region 133 of elevated temperature may include epidermal layer 102 , and dermis layer 106 .
- the conformal region 133 of elevated temperature may include the dermis layer 106 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 and the epidermal layer 102 .
- the conformal region 133 of elevated temperature may include the epidermal layer 102 .
- the conformal region 133 of elevated temperature may include targeted skin surface 104 .
- the conformal region 133 of elevated temperature may include a junction between the dermis layer 106 and the SMAS layer 110 .
- transducer 125 is configured to create conformal region 133 of elevated temperature and second conformal region 133 A, in accordance to various embodiments.
- ultrasound probe 105 comprises enclosure 78 containing transducer 125 and optionally position sensor 107 .
- Ultrasound probe 105 can be coupled to targeted skin surface 104 .
- Ultrasound energy 131 and 131 A can be emitted by transducer 125 to create conformal region 133 of elevated temperature and second conformal region 133 A of elevated temperature in subcutaneous tissue 127 .
- weakly focused ultrasound energy 131 and second weakly focused ultrasound energy 131 A can create conformal region 133 of elevated temperature and second conformal region 133 A.
- conformal region 133 of elevated temperature and second conformal region 133 A intersect.
- transducer 125 is elongated and may comprise a plurality of transduction elements. In this configuration, transducer 125 can create conformal region 133 of elevated temperature and second conformal region 133 A along dimension 129 . In this configuration, probe 105 can provide a cosmetic effect to a larger area of targeted skin surface 104 .
- conformal region 133 of elevated temperature can be directed to one or more layers of skin or one or more layers of subcutaneous tissue 127 .
- second conformal region 133 A of elevated temperature can be directed to one or more layers of skin or one or more layers of subcutaneous tissue 127 , as described herein in regards to conformal region 133 of elevated temperature.
- at least a portion both conformal region 133 of elevated temperature and second conformal region 133 A of elevated temperature are directed to the same layer of combination of layers in the subcutaneous tissue 127 .
- ultrasound probe 105 is illustrated.
- ultrasound probe 105 comprises enclosure 78 containing transducer 125 and optionally position sensor 107 .
- Ultrasound probe 105 can be coupled to targeted skin surface 104 .
- Ultrasound energy 131 and 131 A can be emitted by transducer 125 to create conformal region 133 of elevated temperature and second conformal region 133 A of elevated temperature in subcutaneous tissue 127 .
- weakly focused ultrasound energy 131 and second weakly focused ultrasound energy 131 A can create conformal region 133 of elevated temperature and second conformal region 133 A
- position sensor 107 may determine a distance 117 between pulses of therapeutic ultrasound energy 108 to create a plurality of conformal region 133 of elevated temperature which are evenly spaced or disposed in any spatial configuration in one-, two-, or three-dimensions. As ultrasound probe 105 is moved in direction 130 , position sensor 107 determines distance 117 , regardless of a speed that ultrasound probe 105 is move, at which a pulse of ultrasound energy 131 or 131 A is to be emitted in to ROI. In various embodiments ultrasound probe 105 is triggered automatically via a timer and in combination with a position sensor 107 to assure motion.
- ultrasound probe 105 comprises position sensor 107 .
- Position sensor 107 can be integrated into ultrasound probe 105 or attached to ultrasound probe 105 .
- position sensor 107 is a motion sensor measuring position of ultrasound probe 105 .
- Such a motion sensor can calculate distance traveled along skin surface 104 .
- Such a motion sensor may determine a speed of movement of ultrasound probe 105 along skin surface 104 and determine if the speed is accurate for the cosmetic procedure that is elected. For example if the speed is too fast, motion sensor can signal an indicator to slow the speed and/or can signal transducer 125 to stop emitting ultrasound energy 131 and 131 A.
- position sensor 107 can include a laser position sensor.
- position sensor 107 can track position like a computer mouse that uses a laser sensor as opposed to an older version of a mouse with a roller ball.
- Position sensor 107 can communicate position data versus time to a display to track a position of ultrasound probe 105 , such as, for example, overlaid on an image of ROI, overlaid on an image of skin surface 104 , as referenced to geotagged features, as reference to targeted location, as referenced to a prior procedures, and combinations thereof.
- a treatment plan can include a movement pattern of ultrasound probe 105 .
- Such a movement pattern can be displayed and the position sensor 107 can track a position of ultrasound probe 105 during a cosmetic procedure as compared to the movement pattern. Tracking ultrasound probe 105 with position sensor and comparing the tracked movement to a predetermined movement may be useful as a training tool.
- laser position sensor can geotag a feature on skin surface 104 .
- position sensor 107 may determine a distance 117 between pulses of therapeutic ultrasound energy 108 to create a plurality of lesions 25 which are evenly spaced or disposed in any spatial configuration in one-, two-, or three-dimensions. As ultrasound probe 105 is moved in direction 130 , position sensor 107 determines distance 117 , regardless of a speed that ultrasound probe 105 is move, at which a pulse of therapeutic ultrasound energy 108 is to be emitted in to ROI. In various embodiments ultrasound probe 105 is triggered automatically via a timer and in combination with a position sensor 107 to assure motion.
- Position sensor 107 may be located behind a transducer, in front of a transducer array, or integrated into a transducer array.
- Ultrasound probe 105 may comprise more than one position sensor 107 , such as, for example, a laser position sensor and a motion sensor, or a laser position sensor and a visual device, or a motion sensor and a visual device, or a laser position sensor, a motion sensor, and a visual device. Additional embodiments of position sensor 107 may be found in U.S. Pat. No. 7,142,905, entitled “Visual Imaging System for Ultrasonic Probe” issued Nov. 28, 2006, and U.S. Pat. No. 6,540,679, entitled “Visual Imaging System for Ultrasonic Probe” issued Apr. 1, 2003, both of which are incorporated by reference.
- Position sensor 107 can be integrated into ultrasound probe 105 or attached to ultrasound probe 105 .
- position sensor 107 is an optical sensor measuring 1-D, 2-D, or 3-D movement 130 of ultrasound probe 105 versus time while probe travels along skin surface 104 .
- Such a position sensor may control conformal region 133 of elevated temperature sequence directly, by using position information in the treatment system to trigger emission of ultrasound energy 131 and 131 A.
- cosmetic enhancement can be triggered when the ultrasound probe 105 reaches a fixed or pre-determined range away from the last ablation zone 112 .
- Speed of motion can be used to control therapeutic ultrasound energy 108 . For example, if the motion is too fast information can be provided to the user to slow down and/or energy can be dynamically adjusted within limits.
- Position information may also be used to suppress energy if crossing over the same spatial position, if desired.
- Such a position sensor 107 may also determine if ultrasound probe 105 is coupled to skin surface 104 , to safely control energy delivery and provide information to users.
- ultrasound probe 105 comprises transducer 125 , as described herein, and may be controlled and operated by a hand-held format control system.
- An external battery charger can be used with rechargeable-type batteries 84 or the batteries 84 can be single-use disposable types, such as M-sized cells.
- Power converters produce voltages for powering a driver/feedback circuit with tuning network driving transducer array 100 .
- Ultrasound probe 105 is coupled to targeted skin surface 104 via one or more tips 88 , which can be composed of at least one of a solid media, semi-solid, such as, for example, a gelatinous media, and liquid media equivalent to an acoustic coupling agent contained within a housing in tip.
- Tip 88 is coupled to targeted skin surface 104 with an acoustic coupling agent.
- ultrasound probe 105 comprises position sensor 107 , as described herein.
- tip 88 may comprise transducer 125 . In such embodiments, the tip 88 and transducer 125 can be disposable and replaceable.
- a microcontroller and timing circuits with associated software and algorithms provide control and user interfacing via a display or LED-type indicators 83 , and other input/output controls 82 , such as switches and audio devices.
- a storage element such as an Electrically Erasable Programmable Read-Only Memory (“EEPROM”), secure EEPROM, tamper-proof EEPROM, or similar device can hold calibration and usage data.
- EEPROM Electrically Erasable Programmable Read-Only Memory
- secure EEPROM secure EEPROM
- tamper-proof EEPROM or similar device can hold calibration and usage data.
- a motion mechanism with feedback can be controlled to scan the transducer 125 in a linear pattern or a two-dimensional pattern or over a varied depth.
- Other feedback controls comprise capacitive, acoustic, or other coupling detection means, limiting controls, and thermal sensor.
- EEPROM can be coupled with at least one of tip 88 , transducer array 100 , thermal sensor, coupling detector, and tuning network
- data from EEPROM can be downloaded to a user's computer via any interface type, such as, for example, a USB interface, a RS 232 interface, a IEEE interface, a fire-wire interface, a blue tooth interface, an infrared interface, a 802.1 interface, via the web, and the like.
- Downloadable data can include hours of use, frequency during use, power levels, depths, codes from tips used, error codes, user ID, and other such data. The data can be parsed by user ID so more than one user can track user data.
- EEPROM can be interfaced, using any of the methods or devices described herein, to a computer or the web to receive software updates. Still further, EEPROM can be interfaced, using any of the methods or devices described herein, to a computer or the web for at least one of diagnosis, trouble shooting, service, repair, and combinations thereof.
- ultrasound probe 105 can be in communication with wireless device 200 via wireless interface 204 .
- wireless device 200 has display 206 and a user interface such as, for example, a keyboard.
- Examples of wireless device 200 can include but are not limited to: personal data assistants (“PDA”), cell phone, iPhone, iPad, computer, laptop, netbook, or any other such device now known or developed in the future.
- Examples of wireless interface 204 include but are not limited to any wireless interface described herein and any such wireless interface now known or developed in the future.
- ultrasound probe 105 comprises any hardware, such as, for example, electronics, antenna, and the like, as well as, any software that may be used to communicate via wireless interface 204 .
- device 200 can display an image generated by handheld probe 105 . In various embodiments, device 200 can control handheld ultrasound probe 105 . In various embodiments, device 200 can store data generated by handheld ultrasound probe 105 .
- transducer 125 optionally and imaging transducer array 110 , and optionally, position sensor 107 can held within enclosure 78 .
- enclosure 78 is designed for comfort and control while used in an operator's hand.
- Enclosure 78 may also contain various electronics, such as, for example, EEPROM, interface connection, motion mechanisms, and/or ram for holding programs, and combinations thereof.
- Ultrasound energy 131 and 131 A from transducer 125 may be spatially and/or temporally controlled at least in part by changing the spatial parameters of transducer 125 , such as the placement, distance, treatment depth and transducer 125 structure, as well as by changing the temporal parameters of transducer 125 , such as the frequency, drive amplitude, and timing, with such control handled via controller in hand-held assembly of ultrasound probe 105 .
- ultrasound probe 105 comprises a transducer 125 capable of emitting ultrasound energy 131 and 131 A into ROI. This may heat ROI at a specific depth to target tissue as described herein
- Ultrasound energy 131 creates create conformal region 133 of elevated temperature in a tissue layer, at which a temperature of tissue is raised by 10° C. to 15° C., or is raised to a temperature in the range form about 4° C. to about 55° C., or from about 43° C. to about 48° C., or below a threshold of ablation of the tissue.
- the ultrasound energy level is in a range of about 0.1 joules to about 500 joules in order to create an ablative lesion.
- the ultrasound energy 108 level can be in a range of from about 0.1 joules to about 100 joules, or from about 1 joules to about 50 joules, or from about 0.1 joules to about 10 joules, or from about 50 joules to about 100 joules, or from about 100 joules to about 500 joules, or from about 50 joules to about 250 joules.
- the amount of time ultrasound energy is applied at these levels to create a lesion varies in the range from approximately 1 millisecond to several minutes.
- a range can be from about 1 millisecond to about 5 minutes, or from about 1 millisecond to about 1 minute, or from about 1 millisecond to about 30 seconds, or from about 1 millisecond to about 10 seconds, or from about 1 millisecond to about 1 second, or from about 1 millisecond to about 0.1 seconds, or about 0.1 seconds to about 10 seconds, or about 0.1 seconds to about 1 second, or from about 1 millisecond to about 200 milliseconds, or from about 1 millisecond to about 0.5 seconds.
- the frequency of the ultrasound energy can be in a range from about 0.1 MHz to about 100 MHz, or from about 0.1 MHz to about 50 MHz, or from about 1 MHz to about 50 MHz or about 0.1 MHz to about 30 MHz, or from about 10 MHz to about 30 MHz, or from about 0.1 MHz to about 20 MHz, or from about 11 MHz to about 20 MHz, or from about 20 MHz to about 30 MHz.
- the frequency of the ultrasound energy can be in a range from about 1 MHz to about 12 MHz, or from about 5 MHz to about 15 MHz, or from about 2 MHz to about 12 MHz or from about 3 MHz to about 7 MHz.
- the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 0 mm to about 150 mm, or from about 0 mm to about 100 mm, or from about 0 mm to about 50 mm, or from about 0 mm to about 30 mm, or from about 0 mm to about 20 mm, or from about 0 mm to about 10 mm, or from about 0 mm to about 5 mm.
- the ultrasound energy can be emitted to depths below a skin surface in a range from about 5 mm to about 150 mm, or from about 5 mm to about 100 mm, or from about 5 mm to about 50 mm, or from about 5 mm to about 30 mm, or from about 5 mm to about 20 mm, or from about 5 mm to about 10 nm.
- the ultrasound energy can be emitted to depths below a skin surface in a range from about 10 mm to about 150 mm, or from about 10 mm to about 100 mm, or from about 10 mm to about 50 mm, or from about 10 mm to about 30 mm, or from about 10 mm to about 20 mm, or from about 0 mm to about 10 mm.
- the ultrasound energy can be emitted to depths at or below a skin surface in the range from about 20 mm to about 150 mm, or from about 20 mm to about 100 mm, or from about 20 mm to about 50 mm, or from about 20 mm to about 30 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 30 mm to about 150 mm, or from about 30 mm to about 100 mm, or from about 30 mm to about 50 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 50 mm to about 150 mm, or from about 50 mm to about 100 mm.
- the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 20 mm to about 60 mm, or from about 40 mm to about 80 mm, or from about 10 mm to about 40 mm, or from about 5 mm to about 40 mm, or from about 0 mm to about 40 mm, or from about 10 mm to about 30 mm, or from about 5 mm to about 30 mm, or from about 0 mm to about 30 mm.
- the probe 105 comprises a transducer 125 operating frequency range of 2-12 MHz or 4-8 MHz or 6 MHz. In various embodiments, the probe 105 comprises a transducer 125 with an operating power of about 1 watt. In various embodiments, the probe 105 comprises a transducer 125 having an operating intensity range: 10-500 W/cm 2 or 20-100 W/cm 2 . In various embodiments, the probe 105 comprises a transducer 125 that is a consumable transducer.
- medicant and/or cosmeceutical can include a drug, a medicine, or a protein, and combinations thereof.
- Medicant and/or cosmeceutical can also include a vaccine, blood or blood component, allergenic, somatic cell, gene therapy, tissue, recombinant therapeutic protein, or living cells that are used as therapeutics to treat diseases or as actives to produce a cosmetic effect.
- Medicant and/or cosmeceutical can also include a biologic, such as for example a recombinant DNA therapy, synthetic growth hormone, monoclonal antibodies, or receptor constructs.
- Medicant and/or cosmeceutical can also include adsorbent chemicals, such as zeolites, and other hemostatic agents are used in sealing severe injuries quickly.
- Thrombin and fibrin glue are used surgically to treat bleeding and to thrombose aneurysms.
- Medicant and/or cosmeceutical can include Desmopressin is used to improve platelet function by activating arginine vasopressin receptor 1 A.
- Medicant and/or cosmeceutical can include coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in patients with impaired coagulation factor synthesis or increased consumption.
- Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly-used coagulation factor products.
- Recombinant activated human factor VII can be used in the treatment of major bleeding.
- Medicant and/or cosmeceutical can include tranexamic acid and aminocaproic acid, can inhibit fibrinolysis, and lead to a de facto reduced bleeding rate.
- medicant and/or cosmeceutical can include steroids like the glucocorticoid cortisol.
- a medicant and/or cosmeceutical can include can include compounds as alpha lipoic Acid, DMAE, vitamin C ester, tocotrienols, and phospholipids.
- Medicant 202 can be a pharmaceutical compound such as for example, cortisone, Etanercept, Abatacept, Adalimumrab, or Infliximab.
- Medicant 202 can include platelet-rich plasma (PRP), mesenchymal stem cells, or growth factors.
- PRP platelet-rich plasma
- mesenchymal stem cells or growth factors.
- PRP is typically a fraction of blood that has been centrifuged. The PRP is then used for stimulating healing of the injury.
- the PRP typically contains thrombocytes (platelets) and cytokines (growth factors).
- the PRP may also contain thrombin and may contain fibenogen, which when combined can form fibrin glue.
- Medicant 202 can be a prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma, which are commonly-used coagulation factor products.
- Medicant 202 can be a recombinant activated human factor VII, which can be used in the treatment of major bleeding.
- Medicant 202 can include tranexamic acid and aminocaproic acid, can inhibit fibrinolysis, and lead to a de facto reduced bleeding rate.
- medicant can be Botox.
- a medicant and/or cosmeceutical can include platelet-rich plasma (PRP), mesenchymal stem cells, or growth factors.
- PRP platelet-rich plasma
- mesenchymal stem cells or growth factors.
- PRP is typically a fraction of blood that has been centrifuged. The PRP is then used for stimulating healing of the injury.
- the PRP typically contains thrombocytes (platelets) and cytokines (growth factors).
- the PRP may also contain thrombin and may contain fibenogen, which when combined can form fibrin glue.
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Abstract
In some embodiments, the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface. Improving the appearance of the skin surface can be at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
Description
- This application claims priority to and the benefit of U.S. Provisional Patent Application Ser. No. 61/506, 125, entitled “Systems and Methods for Creating Shaped Lesions” filed Jul. 10, 2011; U.S. Provisional Patent Application Ser. No. 61/506,127, entitled “Systems and Methods for Treating Injuries to Joints and Connective Tissue,” filed Jul. 10, 2011; U.S. Provisional Patent Application Ser. No. 61/506,126, entitled “System and Methods for Accelerating Healing of Implanted Materials and/or Native Tissue,” filed Jul. 10, 2011; U.S. Provisional Patent Application Ser. No. 61/506,160, entitled “Systems and Methods for Cosmetic Rejuvenation,” filed Jul. 10, 2011; U.S. Provisional Patent Application Ser. No. 61/506,163, entitled “Methods and Systems for Ultrasound Treatment,” filed Jul. 10, 2011; U.S. Provisional Patent Application Ser. No. 61/506,609, entitled “Systems and Methods for Monitoring Ultrasound Power Efficiency,” filed Jul. 11, 2011; and U.S. Provisional Patent Application Ser. No. 61/506,610, entitled “Methods and Systems for Controlling Acoustic Energy Deposition into a Medium,” filed Jul. 11, 2011; all of which are incorporated by reference herein.
- Energy, such as ultrasound energy, can be applied to treat tissue or perform traditionally invasive procedures in a non-invasive manner. The application of ultrasound energy provides both thermal and/or mechanical effects that help treat certain ailments such as acne and enable many traditional invasive procedures to be performed non-invasively.
- Typically, ultrasound devices only affect a specific portion of the tissue at a certain depth within the region of interest based upon the configuration of the particular ultrasound device. For example, an ultrasound device might be configured to affect an area five millimeters below the surface of the skin. The tissue from the surface of the skin to the depth of five millimeters is spared and not treated by the ultrasound energy. Sparing these intervening spaces of tissue hinders the overall beneficial effect of ultrasound as treatment of this intervening tissue increases ultrasound treatment's overall efficacy. Accordingly, new approaches of cosmetic enhancement of skin are needed, which are rapid and non-invasive.
- Various embodiments described herein provide methods and systems for cosmetic enhancement of tissue. Accordingly, ultrasound energy can be focused, unfocused or defocused and can be applied to a region of interest containing subcutaneous tissue below a surface to achieve a cosmetic effect.
- Various embodiments provide a method for improving an appearance of a skin surface. In some embodiments, the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface.
- In some embodiments, the improving the appearance of the targeted portion of the skin surface comprises at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
- Various embodiments provide a method for improving an appearance of a skin surface. In some embodiments, the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface.
- Various embodiments provide a system for improving the appearance of a skin surface. In some embodiments, the system can further comprise a hand-held probe comprising: an ultrasound transducer; an indicator display; at least one input/output control; a position sensor; and a rechargeable battery configured to power the hand-held probe. In some embodiments, the system can further comprise a controller configured to control the hand-held probe and a wireless interface configured to couple communication between the controller and the hand-held probe.
- In some embodiments, the controller is at least one of a personal data assistant, a cell phone, an iPhone, an iPad, a computer, a laptop, and a netbook. In some embodiments, the transducer is configured as a 2 dimensional linear array.
- The present disclosure will become more fully understood from the detailed description and the accompanying drawings, wherein:
-
FIG. 1 is a flow chart illustrating methods of cosmetic enhancement, according to various non-limiting embodiments; -
FIG. 2 is a flow chart illustrating methods according to various non-limiting embodiments; -
FIG. 3 is a cross sectional view illustrating ultrasound energy directed to various subcutaneous tissue layers below a surface, according to various non-limiting embodiments; -
FIG. 4 is a cross sectional view illustrating ultrasound energy directed to two targets in subcutaneous tissue below a surface, according to various non-limiting embodiments; -
FIG. 5 is a cross sectional view illustrating a conformal region of elevated temperature in subcutaneous tissue, according to various non-limiting embodiments; -
FIG. 6 is a cross sectional view illustrating a conformal region of elevated temperature in various layers of subcutaneous tissue, according to various non-limiting embodiments; -
FIG. 7 is a cross sectional view illustrating conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue, according to various non-limiting embodiments; -
FIG. 8 is a prospective view illustrating conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue, according to various non-limiting embodiments; -
FIG. 9 is a cross sectional view illustrating conformal region of elevated temperature and second conformal region of elevated temperature in various layers of subcutaneous tissue, according to various non-limiting embodiments; -
FIGS. 10 A-B are a cross sectional views illustrating conformal region of elevated temperature and second conformal region of elevated temperature in soft tissue, according to various non-limiting embodiments; -
FIGS. 11 A-B are a cross sectional views illustrating conformal region of elevated temperature and second conformal region of elevated temperature in soft tissue, according to various non-limiting embodiments; -
FIG. 12 is a cross sectional view illustrating a plurality of conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue, according to various non-limiting embodiments; and -
FIG. 13 is a cross sectional view illustrating a hand held probe, according to various non-limiting embodiments. - The following description is merely exemplary in nature and is in no way intended to limit the various embodiments, their application, or uses. As used herein, the phrase “at least one of A, B, and C” should be construed to mean a logical (A or B or C), using a non-exclusive logical “or.” As used herein, the phrase “A, 3 and/or C” should be construed to mean (A, B, and C) or alternatively (A or B or C), using a non-exclusive logical “or.” It should be understood that steps within a method may be executed in different order without altering the principles of the present disclosure.
- The drawings described herein are for illustrative purposes only of selected embodiments and not all possible implementations, and are not intended to limit the scope of any of the various embodiments disclosed herein or any equivalents thereof. It is understood that the drawings are not drawn to scale. For purposes of clarity, the same reference numbers will be used in the drawings to identify similar elements.
- The various embodiments may be described herein in terms of various functional components and processing steps. It should be appreciated that such components and steps may be realized by any number of hardware components configured to perform the specified functions. For example, various embodiments may employ various medical treatment devices, visual imaging and display devices, input terminals and the like, which may carry out a variety of functions under the control of one or more control systems or other control devices. In addition, the embodiments may be practiced in any number of medical contexts and that the various embodiments relating to a method and system for acoustic tissue treatment as described herein are merely indicative of exemplary applications for the invention. For example, the principles, features and methods discussed may be applied to any medical application. Further, various aspects of the various embodiments may be suitably applied to cosmetic applications. Moreover, some of the embodiments may be applied to cosmetic enhancement of skin and/or various subcutaneous tissue layers.
- According to various embodiments, methods and systems useful for cosmetic rejuvenation of face and body are provided herein. The methods and systems provided herein are noninvasive, for example, no cutting or injecting into the skin is required. Cosmetic rejuvenation of the face and/or body using the methods and systems provided herein minimize recover time and may in some cases eliminate downtime for recovery. Further cosmetic rejuvenation using the methods and systems provided herein minimize discomfort to a patient having such a rejuvenation procedure.
- Various embodiments provide a hand-held extracorporeal apparatus, which emits controlled ultrasound energy into layers of the skin to create a conformal region of elevated temperature in tissue of the skin. In some embodiments, a system useful for cosmetic rejuvenation of the face and/or body is in a handheld format which may include a rechargeable power supply.
- In various embodiments, rejuvenation is a reversal or an attempt to reverse the aging process. Rejuvenation can be the reversal of aging and is namely repair of the damage that is associated with aging or replacement of damaged tissue with new tissue. In some embodiments, cosmetic enhancement can refer to procedures, which may not be medically necessary but can be used to improve or change the appearance of a portion of the body. For example, a cosmetic enhancement can be a procedure but not limited to procedures that are used to improve or change the appearance of a nose, eyes, eyebrows and/or other facial features, or to improve or change the appearance and/or the texture and/or the elasticity of skin, or to improve or change the appearance of a mark or scar on a skin surface, or to improve or change the appearance and/or the content of fat near a skin surface, or the targeting of a gland to improve or change the appearance a portion of the body. In at least some embodiments, cosmetic enhancement is a non-surgical and non-invasive procedure. In various embodiments, cosmetic enhancement provides rejuvenation to at least one portion of the body.
- In some embodiments, methods of cosmetic enhancement can increase elasticity of skin by thinning a dermis layer, thereby rejuvenating a portion of skin. In some embodiments, methods of cosmetic enhancement can stimulate initiation of internal body resources for the purpose of repairing an injury and/or cell defienticy.
- Various embodiments provide a method for improving an appearance of a skin surface. In some embodiments, the method can comprise locating a targeted portion of skin surface; targeting a region of interest comprising the targeted portion of the skin surface and subcutaneous tissue below the skin surface; delivering ultrasound energy to the region of interest; producing an effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface.
- In some embodiments, the method can further comprise imaging the subcutaneous tissue below the skin surface. In some embodiments, the method can further comprise administering a medicant to the region of interest. In some embodiments, the method can further comprise activating the medicant in the region of interest with the ultrasound energy at the same frequency or a different frequency.
- In some embodiments, the method can further comprise delivering a secondary energy to the region of interest. In some embodiments, the secondary energy is a photon-based energy. In some embodiments, the secondary energy is radio frequency based energy. In some embodiments, the method can further comprise determining results of the effect in at least one of the skin surface and the subcutaneous tissue.
- In some embodiments, the effect is a cosmetic effect. In some embodiments, the cosmetic effect is at least one of increasing skin elasticity/tighten skin, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, reducing fat, reducing cellulite, treating and/or preventing acne, treating hyperhidrosis, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, treating of soft tissue in the region of interest, rejuvenating skin, increasing skin elasticity, increasing collagen in tissue, smoothing of the texture of skin, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, lifting of skin, body sculpting, generating new tissue in the subcutaneous tissue, and combinations thereof.
- In some embodiments, the improving the appearance of the targeted portion of the skin surface comprises at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
- Various embodiments provide a method for improving an appearance of a skin surface. In some embodiments, the method can comprise locating a targeted portion of skin surface; delivering ultrasound energy to subcutaneous tissue below the skin surface; producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and improving the appearance of the targeted portion of the skin surface.
- In some embodiments, the method can further comprise delivering a medicant to the subcutaneous tissue below the skin surface. In some embodiments, the method can further comprise comprising activating the medicant in the region of interest with the ultrasound energy at the same frequency or a different frequency. In some embodiments, the method can further comprise delivering a cosmeceutical to the subcutaneous tissue below the skin surface.
- In some embodiments, the method can further comprise delivering a secondary energy to the subcutaneous tissue below the skin surface. In some embodiments, the secondary energy is a photon-based energy. In some embodiments, the secondary energy is radio frequency based energy.
- In some embodiments, the biological effect is at least one of stimulating or increase an amount of heat shock proteins, cause white blood cells to promote healing of a portion of the subcutaneous tissue, accelerating ta wound healing cascade in the subcutaneous tissue, increasing the blood perfusion in the subcutaneous tissue, encouraging collagen growth in the subcutaneous tissue, increasing the liberation of cytokines within the subcutaneous layer, peaking inflammation in the subcutaneous tissue, partially shrinking collagen in a portion of the subcutaneous tissue, denaturing of proteins in the subcutaneous tissue, and combinations thereof.
- In some embodiments, the biological effect is at least one of creating immediate or delayed cell death in the subcutaneous tissue, collagen remodeling in the subcutaneous tissue, disrupting or modifying of biochemical cascades in at least one of the skin surface and the subcutaneous tissue, producing new collagen in the subcutaneous tissue, stimulating cell growth in the subcutaneous tissue, stimulating angiogenesis, stimulating a cell permeability response, enhancing delivery of medicants to in the subcutaneous tissue, and combinations thereof.
- In some embodiments, the improving the appearance of the targeted portion of the skin surface comprises at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
- Various embodiments provide a system for improving the appearance of a skin surface. In some embodiments, the system can further comprise a hand-held probe comprising: an ultrasound transducer; an indicator display; at least one input/output control; a position sensor; and a rechargeable battery configured to power the hand-held probe. In some embodiments, the system can further comprise a controller configured to control the hand-held probe and a wireless interface configured to couple communication between the controller and the hand-held probe.
- In some embodiments, the controller is at least one of a personal data assistant, a cell phone, an iPhone, an iPad, a computer, a laptop, and a netbook. In some embodiments, the transducer is configured as a 2 dimensional linear array.
- In various embodiments, the system and the related method of the present invention apply ultrasound energy to a region of interest at the surface of the patient's skin and ultrasound energy travels from the surface to a location within the region of interest and treats all the tissue within the region of interest with a combined energy profile without sparing any of such tissue.
- In some embodiments, the ultrasound transducer is configured to simultaneously create a first conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue. In some embodiment, the first conformal region of elevated temperature and second conformal region of elevated temperature intersect in the subcutaneous tissue. In some embodiments, the first conformal region of elevated temperature and second conformal region of elevated temperature are positioned perpendicular to each other in the subcutaneous tissue.
- Various embodiments provide a method for treating a surface of skin. In some embodiments, the method can comprise creating a conformal region of elevated temperature; treating a surface and subsurface of skin simultaneously; creating a transitional biological effect on the surface of the skin without causing cell death, a scar, or permanent damage to the surface of the skin; creating a thermal effect to the subsurface of the skin; and initiating a permanent biological effect to the subsurface of the skin. The method can further comprise creating an optically visible effect on the surface of the skin. The transitional biological effect can be one of erythema, edema, and a transitional coagulative point. In some embodiments, the optically visible effect on the surface of the skin can be at least one of at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
- In some embodiments, the permanent biological effect can be at least one of is at least one of stimulating or increase an amount of heat shock proteins, cause white blood cells to promote healing of a portion of the subcutaneous tissue, accelerating ta wound healing cascade in the subcutaneous tissue, increasing the blood perfusion in the subcutaneous tissue, encouraging collagen growth in the subcutaneous tissue, increasing the liberation of cytokines within the subcutaneous layer, peaking inflammation in the subcutaneous tissue, partially shrinking collagen in a portion of the subcutaneous tissue, denaturing of proteins in the subcutaneous tissue, and combinations thereof.
- In some embodiments, the permanent biological effect is at least one of creating immediate or delayed cell death in the subcutaneous tissue, collagen remodeling in the subcutaneous tissue, disrupting or modifying of biochemical cascades in at least one of the skin surface and the subcutaneous tissue, producing new collagen in the subcutaneous tissue, stimulating cell growth in the subcutaneous tissue, stimulating angiogenesis, stimulating a cell permeability response, enhancing delivery of medicants to in the subcutaneous tissue, and combinations thereof.
- With reference to
FIG. 1 , a method ofcosmetic enhancement 100 is illustrated according to various embodiments.Step 10 is identifying a targeted skin surface, which may be located anywhere on the body, such as, for example, in any of the following: face, neck, hands, arms, legs, buttocks, and combinations thereof. Next,Step 12 is targeting a region of interest (“ROI”). The ROI can be located in subcutaneous tissue below the targeted skin surface, which can be anywhere in the body, such as, those listed previously. The subcutaneous tissue can comprise any or all of the following tissues: an epidermal layer, a dermal layer, a fat layer, a SMAS layer, and a muscle layer. Optionally, step 22 is imaging subcutaneous tissue below the targeted skin surface can be betweensteps step 12. - After
step 12,step 14 is directing ultrasound energy to ROI. The ultrasound energy may be focused, defocused, or unfocused. The ultrasound sound energy can be weakly focused. The ultrasound energy can be directed to the subcutaneous tissue layer below the targeted skin surface. The ultrasound energy may be streaming. The ultrasound energy may be directed to a first depth and then directed to a second depth. The ultrasound energy may force a pressure gradient in the subcutaneous tissue layer below the targeted skin surface. The ultrasound energy may be a first ultrasound energy effect, which comprises an ablative or a hemostatic effect, and a second ultrasound energy effect, which comprises at least one of non-thermal streaming, hydrodynamic, diathermic, and resonance induced tissue effects. Directing ultrasound energy to the ROI is a non-invasive technique. As such, the targeted skin surface and the layers above a target point in the subcutaneous layer are spared from injury. Alternatively, the targeted skin surface and the layers above a target point in the subcutaneous layer are heated to a 10° C. to 15° C. above the tissue's natural state. Such treatment does not require an incision in order to reach the subcutaneous tissue layer below the targeted skin surface to enhance the targeted skin surface. - In various embodiments, the ultrasound energy level is in a range of about 0.1 joules to about 500 joules in order to create an ablative lesion. However, the
ultrasound energy 108 level can be in a range of from about 0.1 joules to about 100 joules, or from about 1 joules to about 50 joules, or from about 0.1 joules to about 10 joules, or from about 50 joules to about 100 joules, or from about 100 joules to about 500 joules, or from about 50 joules to about 250 joules. - Further, the amount of time ultrasound energy is applied at these levels to create a lesion varies in the range from approximately 1 millisecond to several minutes. However, a range can be from about 1 millisecond to about 5 minutes, or from about 1 millisecond to about 1 minute, or from about 1 millisecond to about 30 seconds, or from about 1 millisecond to about 10 seconds, or from about 1 millisecond to about 1 second, or from about 1 millisecond to about 0.1 seconds, or about 0.1 seconds to about 10 seconds, or about 0.1 seconds to about 1 second, or from about 1 millisecond to about 200 milliseconds, or from about 1 millisecond to about 0.5 seconds.
- The frequency of the ultrasound energy can be in a range from about 0.1 MHz to about 100 MHz, or from about 0.1 MHz to about 50 MHz, or from about 1 MHz to about 50 MHz or about 0.1 MHz to about 30 MHz, or from about 10 MHz to about 30 MHz, or from about 0.1 MHz to about 20 MHz, or from about 1 MHz to about 20 MHz, or from about 20 MHz to about 30 MHz.
- The frequency of the ultrasound energy can be in a range from about 1 MHz to about 12 MHz, or from about 5 MHz to about 15 MHz, or from about 2 MHz to about 12 MHz or from about 3 MHz to about 7 MHz.
- In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 0 mm to about 150 mm, or from about 0 mm to about 100 mm, or from about 0 mm to about 50 mm, or from about 0 mm to about 30 mm, or from about 0 mm to about 20 mm, or from about 0 mm to about 10 mm, or from about 0 mm to about 5 mm. In some embodiments, the ultrasound energy can be emitted to depths below a skin surface in a range from about 5 mm to about 150 mm, or from about 5 mm to about 100 mm, or from about 5 mm to about 50 mm, or from about 5 mm to about 30 mm, or from about 5 mm to about 20 mm, or from about 5 mm to about 10 mm. In some embodiments, the ultrasound energy can be emitted to depths below a skin surface in a range from about 10 mm to about 150 mm, or from about 10 mm to about 100 mm, or from about 10 mm to about 50 mm, or from about mm to about 30 mm, or from about 10 mm to about 20 mm, or from about 0 mm to about 10 mm.
- In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in the range from about 20 mm to about 150 mm, or from about 20 mm to about 100 mm, or from about 20 mm to about 50 mm, or from about 20 mm to about 30 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 30 mm to about 150 mm, or from about 30 mm to about 100 mm, or from about 30 mm to about 50 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 50 mm to about 150 mm, or from about 50 mm to about 100 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 20 mm to about 60 mm, or from about 40 mm to about 80 mm, or from about 10 mm to about 40 mm, or from about 5 mm to about 40 mm, or from about 0 mm to about 40 nm, or from about 10 mm to about 30 mm, or from about 5 mm to about 30 mm, or from about 0 mm to about 30 mm.
- In various embodiments, the ultrasound energy may be emitted at various energy levels, such as for example, the energy levels described herein. Further, the amount of time ultrasound energy is applied at these levels for various time ranges, such as for example, the ranges of time described herein. The frequency of the ultrasound energy is in various frequency ranges, such as for example, the frequency ranges described herein. The ultrasound energy can be emitted to various depths below a targeted skin surface, such as for example, the depths described herein. The ultrasound energy may coagulate a portion of the subcutaneous tissue layer below the targeted skin surface. The ultrasound energy may score a portion of subcutaneous tissue layer below the targeted skin surface.
- Optionally,
step 24, which is administering a medicant and/or cosmeceutical to the ROI, can be betweensteps - The medicant and/or cosmeceutical can be administered by applying it to the skin above the ROI. The medicant and/or cosmeceutical can be administered to the circulatory system. For example, the medicant and/or cosmeceutical can be in the blood stream and can be activated or moved to the ROI by the ultrasound energy. The medicant and/or cosmeceutical can be administered by injection into or near the ROI. Any naturally occurring proteins, stem cells, growth factors and the like can be used as medicant and/or cosmeceutical in accordance to various embodiments. A medicant and/or cosmeceutical can be mixed in a coupling gel or can be used as a coupling gel.
-
Step 16 is producing a cosmetic effect in the ROI. A cosmetic effect can be increase skin elasticity/tighten skin. A cosmetic effect can be reducing skin oiliness. A cosmetic effect can be reducing skin pore size/smooth skin texture. A cosmetic effect can be reducing hyperpigmentation. A cosmetic effect can be reducing fat and/or cellulite. A cosmetic effect can be treating and/or preventing acne. A cosmetic effect can be treating hyperhidrosis. A cosmetic effect can be reducing an appearance of spider veins and/or rosacea. A cosmetic effect can be reducing an appearance of scars. A cosmetic effect can be reducing an appearance of stretch marks. A cosmetic effect can be treatment of soft tissue. A cosmetic effect can be rejuvenation of skin. A cosmetic effect can be increasing skin elasticity. A cosmetic effect can be increasing collagen in tissue. A cosmetic effect can be a smoothing of the texture of skin. A cosmetic effect can be a tightening of sagging sink. A cosmetic effect may be the rejuvenation of photoaged skin. A cosmetic effect can be increasing a thickness of a dermal layer. A cosmetic effect can be a reduction of wrinkle on a skin surface. A cosmetic effect can be a lifting of skin, for example, a facelift, a neck lift, a brow lift, and/or a jowl lift. A cosmetic effect can be body sculpting. A cosmetic effect can be generating new tissue in the subcutaneous layer. A cosmetic effect can be synergetic with the medicant and/or cosmeceutical administered to ROI insteps 24 and/or 26. Cosmetic effects can be combined. - A cosmetic effect can be produced by a biological effect that initiated or stimulated by the ultrasound energy. A biological effect can be stimulating or increase an amount of heat shock proteins. Such a biological effect can cause white blood cells to promote healing of a portion of the subcutaneous layer in the ROI. A biological effect can be to restart or increase the wound healing cascade at the injury location. A biological effect can be increasing the blood perfusion to the injury location. A biological effect can be encouraging collagen growth. A biological effect may increase the liberation of cytokines and may produce reactive changes within the subcutaneous layer. A biological effect may by peaking inflammation in the ROI. A biological effect may at least partially shrinking collagen portion of soft tissue. A biological effect may be denaturing of proteins in the ROI.
- A biological effect may be creating immediate or delayed cell death (apoptosis) in the ROI. A biological effect may be collagen remodeling in the ROI. A biological effect may be the disruption or modification of biochemical cascades. A biological effect may be the production of new collagen. A biological effect may a stimulation of cell growth in the ROI. A biological effect may be angiogenesis. A biological effect may a cell permeability response. A biological effect may be an enhanced delivery of medicants to soft tissue.
- In various embodiments, ultrasound energy is deposited in the subcutaneous layer changes at least one of concentration and activity of inflammatory mediators (TNF-A, IL-1) as well as growth factors (TGF-B1, TGF-B3) below the targeted skin surface.
- Optionally,
step 26, which is administering medicant and/or cosmeceutical to ROI, can be betweensteps step 16. The medicant and/or cosmeceutical useful instep 26 are essentially the same as those discussed forstep 24. - In various embodiments, ultrasound energy is deposited, which can stimulate a change in at least one of concentration and activity of one or more of the following: Adrenomedullin (AM), Autocrine motility factor, Bone morphogenetic proteins (BMPs), Brain-derived neurotrophic factor (BDNF), Epidermal growth factor (EGF), Erythropoietin (EPO), Fibroblast growth factor (FGF), Glial cell line-derived neurotrophic factor (GDNF), Granulocyte colony-stimulating factor (G-CSF), Granulocyte macrophage colony-stimulating factor (GM-CSF), Growth differentiation factor-9 (GDF9), Hepatocyte growth factor (HGF), Hepatoma-derived growth factor (HDGF), Insulin-like growth factor (NGF), Migration-stimulating factor, Myostatin (GDF-8), Nerve growth factor (NGF) and other neurotrophins, Platelet-derived growth factor (PDGF), Thrombopoietin (TPO), Transforming growth factor alpha (TGF-α), Transforming growth factor beta (TGF-β), Tumor necrosis factor-alpha (TNF-α), Vascular endothelial growth factor (VEGF), Wnt Signaling Pathway, placental growth factor (PlGF), [(Foetal Bovine Somatotrophin)](FBS), IL-1-Cofactor for IL-3 and IL-6, which can activate T cells, IL-2-T-cell growth factor, which can stimulate IL-1 synthesis and can activate B-cells and NK cells, IL-3, which can stimulate production of all non-lymphoid cells, IL-4-Growth factor for activating B cells, resting T cells, and mast cells, IL-5, which can induce differentiation of activated B cells and eosinophils, IL-6, which can stimulate Ig synthesis and growth factor for plasma cells, IL-7 growth factor for pre-B cells, and/or any other growth factor not listed herein, and combinations thereof.
- Further, medicants, as described above, can include a drug, a medicine, or a protein, and combinations thereof. Medicants can also include adsorbent chemicals, such as zeolites, and other hemostatic agents are used in sealing severe injuries quickly. Thrombin and fibrin glue are used surgically to treat bleeding and to thrombose aneurysms. Medicants can include Desmopressin is used to improve platelet function by activating arginine vasopressin receptor 1A. Medicants can include coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in patients with impaired coagulation factor synthesis or increased consumption. Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly-used coagulation factor products. Recombinant activated human factor VII can be used in the treatment of major bleeding. Medicants can include tranexamic acid and aminocaproic acid, can inhibit fibrinolysis, and lead to a de facto reduced bleeding rate. In addition, medicants can include steroids like the glucocorticoid cortisol.
- Optionally, after
step 12, step 25, which is directing secondary energy to the ROT can be substantially simultaneous with or be part ofstep 16. However, step 25 can be administered at least one of before and afterstep 16. Step 25 can be alternated withstep 16, which can create a pulse of two different energy emissions to the ROI. - Optionally, after step 2, step 25, which is directing secondary energy to the ROI can be substantially simultaneous with or be part of
step 16. However, step 25 can be administered at least one of before and afterstep 16. Step 25 can be alternated withstep 16, which can create a pulse of two different energy emissions to the ROI. Secondary energy can be provided by a laser source, or an intense pulsed light source, or a light emitting diode, or a radio frequency, or a plasma source, or a magnetic resonance source, or a mechanical energy source, or any other photon-based energy source. Secondary energy can be provided by any appropriate energy source now known or created in the future. More than one secondary energy source may be used for step 25. - Furthermore, various embodiments provide energy, which may be a first energy and a second energy. For example, a first energy may be followed by a second energy either immediately or after a delay period. In another example, a first energy and a second energy can be delivered simultaneously. In some embodiments, the first energy and the second energy is ultrasound energy. In some embodiments, the first energy is ultrasound and the second energy is generated by one of a laser, an intense pulsed light, a light emitting diode, a radiofrequency generator, photon-based energy source, plasma source, a magnetic resonance source, or a mechanical energy source, such as for example, pressure, either positive or negative. In other embodiments, energy may be a first energy, a second energy, and a third energy, emitted simultaneously or with a time delay or a combination thereof. In some embodiments, energy may be a first energy, a second energy, a third energy, and an nth energy, emitted simultaneously or with a time delay or a combination thereof. Any of the a first energy, a second energy, a third energy, and a nth may be generated by at least one of a laser, an intense pulsed light, a light emitting diode, a radiofrequency generator, an acoustic source, photon-based energy source, plasma source, a magnetic resonance source, and/or a mechanical energy source.
-
Step 20 is cosmetically enhancing the targeted skin surface. Optionally, betweensteps step 30, which is determining results. If the results ofstep 30 are acceptable within the parameters of the treatment then Yes direction 34 is followed to step 20. If the results ofstep 30 are not acceptable within the parameters of the treatment then Nodirection 32 is followed back to step 12. Further examples and variations oftreatment method 100 are discussed herein. - Depending at least in part upon the desired bio-effect and the subcutaneous tissue being treated,
method 100 may be used with an extracorporeal, non-invasive procedure. Also, depending at least in part upon the specific bio-effect and tissue targeted, temperature may increase within ROI may range from approximately 10° C. to about 15° C. Other bio-effects to target tissue can include heating, cavitation, streaming, or vibro-accoustic stimulation, and combinations thereof. - In addition, various different subcutaneous tissues may be treated by
method 100 to produce different bio-effects, according to some embodiments of the present disclosure. According to various embodiments ofmethod 100, ultrasound probe is coupled directly to ROI, as opposed to targetedskin surface 104, to affect the subcutaneous tissue. - With reference to
FIG. 2 , amethod 150 of cosmetic rejuvenation is illustrated, which can be a subset ofmethod 100, as illustrated inFIG. 1 .Step 50 is identifying a skin surface. The skin surface can be located anywhere on the body. However, the skin surface may be located on the face and/or neck. The skin surface contains a defect or other undesirable characteristic that is to be cosmetically enhanced or rejuvenated. The defect or other undesirable characteristic may be, for example, but not limited to a wrinkle, oiliness, pore size, rough skin texture, sun spots, liver spots, sagging skin, lack of glow, a scar, a stretch mark, a blemish, and the like. - Step 60 is directing ultrasound energy into tissue below the skin surface. The ultrasound energy may be unfocused and deposited in a volume that spans from the skin surface into one or more of subcutaneous tissue below. The ultrasound energy can have any of the characteristics as described herein. The ultrasound energy can be controlled using spatial parameters. The ultrasound energy can be controlled using temporal parameters. The ultrasound energy can be controlled using a combination of temporal parameters and spatial parameters. Also, depending at least in part upon the specific bio-effect and tissue targeted, temperature of the subcutaneous tissue may increase within ROI may range from approximately 10° C. to about 15° C.
- In between
step 50 and step 60,option step 55 may be implemented, which is coupling a medicant or cosmeceutical to the skin surface. Ifstep 55 is implemented, step 65 can be employed which is driving the medicant or cosmeceutical in to the subcutaneous layer below the skin surface. The medicant or cosmeceutical may be driven into the subcutaneous layer using the ultrasound energy of step 60 or an alternate frequency of ultrasound energy. - After step 60,
optional step 67 can be employed, which is directing a second energy below the skin surface. The second energy can be a second ultrasound energy having different characteristics than the ultrasound energy in step 60. The second energy can be provided by a laser source, or an IPL source, or a radio frequency, or a plasma source, or a magnetic resonance source. Secondary energy can be provided by any appropriate energy source now known or created in the future. More than one secondary energy source may be used forstep 67 -
Step 70 is producing a bio-effect in tissue below the skin surface. A biological effect can be stimulating or increase an amount of heat shock proteins. Such a biological effect can cause white blood cells to promote healing of a portion of the subcutaneous layer in the ROI. A biological effect can be to restart or increase the wound healing cascade at the injury location. A biological effect can be increasing the blood perfusion to the injury location. A biological effect can be encouraging collagen growth. A biological effect may increase the liberation of cytokines and may produce reactive changes within the subcutaneous layer. A biological effect may by peaking inflammation in the ROI. A biological effect may at least partially shrinking collagen portion of soft tissue. A biological effect may be denaturing of proteins in the ROI. - A biological effect may be creating immediate or delayed cell death (apoptosis) in the ROI. A biological effect may be collagen remodeling in the ROI. A biological effect may be the disruption or modification of biochemical cascades. A biological effect may be the production of new collagen. A biological effect may a stimulation of cell growth in the ROI. A biological effect may be angiogenesis. A biological effect may a cell permeability response. A biological effect may be an enhanced delivery of medicants to soft tissue.
-
Step 80 is improving an appearance of the skin surface. This can be a cosmetic effect. The improving an appearance of the skin surface can be an increase in skin elasticity. The improving an appearance of the skin surface can be reducing skin oiliness. The improving an appearance of the skin surface can be reducing skin pore size. The improving an appearance of the skin surface can be smoothing skin texture. The improving an appearance of the skin surface can be reducing hyperpigmentation. The improving an appearance of the skin surface can be treating and/or preventing acne. The improving an appearance of the skin surface can be reducing a blemish. The improving an appearance of the skin surface can be reducing an appearance of spider veins and/or rosacea. The improving an appearance of the skin surface can be reducing an appearance of scars. The improving an appearance of the skin surface can be reducing an appearance of stretch marks. The improving an appearance of the skin surface can be rejuvenation of skin. The improving an appearance of the skin surface can be increasing collagen in tissue. The improving an appearance of the skin surface can be a tightening of sagging sink. The improving an appearance of the skin surface can be the rejuvenation of photoaged skin. The improving an appearance of the skin surface can be increasing a thickness of a dermal layer. The improving an appearance of the skin surface can be a reduction of wrinkle on a skin surface. The improving an appearance of the skin surface can be generating new tissue in the subcutaneous layer. The improving an appearance of the skin surface can be synergetic with the medicant and/or cosmeceutical administered to ROI insteps - Now moving to
FIG. 3 , a cross sectional view of tissue layers and ultrasound energy directed to a subcutaneous layer, according to various embodiments, is illustrated. Typically, ultrasound energy propagates as a wave with relatively little scattering, over depths up to many centimeters in tissue depending on the ultrasound frequency. The focal spot size achievable with any propagating wave energy depends on wavelength. Ultrasound wavelength is equal to the acoustic velocity divided by the ultrasound frequency. Attenuation (absorption, mainly) of ultrasound by tissue also depends on frequency. Shaped conformal distribution of elevated temperature can be created through adjustment of the strength, depth, and type of focusing, energy levels and timing cadence. For example, focused ultrasound can be used to create precise arrays of microscopic thermal ablation zones.Ultrasound energy 120 can produce an array of ablation zones deep into the layers of the soft tissue. Detection of changes in the reflection of ultrasound energy can be used for feedback control to detect a desired effect on the tissue and used to control the exposure intensity, time, and/or position. - In various embodiment,
ultrasound probe 105 is configured with the ability to controllably produce conformal distribution of elevated temperature in soft tissue withinROI 115 through precise spatial and temporal control of acoustic energy deposition, i.e., control ofultrasound probe 105 is confined within selected time and space parameters, with such control being independent of the tissue. Theultrasound energy 120 can be controlled using spatial parameters. Theultrasound energy 120 can be controlled using temporal parameters. Theultrasound energy 120 can be controlled using a combination of temporal parameters and spatial parameters. - In accordance with various embodiments, control system and
ultrasound probe 105 can be configured for spatial control ofultrasound energy 120 by controlling the manner of distribution of theultrasound energy 120. For example, spatial control may be realized through selection of the type of one or more transducerconfigurations insonifying ROI 115, selection of the placement and location ofultrasound probe 105 for delivery ofultrasound energy 120 relative toROI 115 e.g.,ultrasound probe 105 being configured for scanning over part or whole ofROI 115 to produce contiguous thermal injury having a particular orientation or otherwise change in distance fromROI 115, and/or control of other environment parameters, e.g., the temperature at the acoustic coupling interface can be controlled, and/or the coupling ofultrasound probe 105 to tissue. Other spatial control can include but are not limited to geometry configuration ofultrasound probe 105 or transducer assembly, lens, variable focusing devices, variable focusing lens, stand-offs, movement of ultrasound probe, in any of six degrees of motion, transducer backing, matching layers, number of transduction elements in transducer, number of electrodes, or combinations thereof. - In various embodiments, control system and
ultrasound probe 105 can also be configured for temporal control, such as through adjustment and optimization of drive amplitude levels, frequency, waveform selections, e.g., the types of pulses, bursts or continuous waveforms, and timing sequences and other energy drive characteristics to control thermal ablation of tissue. Other temporal control can include but are not limited to full power burst of energy, shape of burst, timing of energy bursts, such as, pulse rate duration, continuous, delays, etc., change of frequency of burst, burst amplitude, phase, apodization, energy level, or combinations thereof. - The spatial and/or temporal control can also be facilitated through open-loop and closed-loop feedback arrangements, such as through the monitoring of various spatial and temporal characteristics. As a result, control of acoustical energy within six degrees of freedom, e.g., spatially within the X, Y and Z domain, as well as the axis of rotation within the XY, YZ and XZ domains, can be suitably achieved to generate conformal distribution of elevated temperature of variable shape, size and orientation. For example, through such spatial and/or temporal control,
ultrasound probe 105 can enable the regions of elevated temperature possess arbitrary shape and size and allow the tissue to be heated in a controlled manner. - The
subcutaneous tissue 127 layers illustrated are targetedskin surface 104,epidermal layer 102,dermis layer 106,fat layer 108,SMAS layer 110, and muscle andconnective tissue layer 112.Ultrasound probe 105 emitsultrasound energy 120 inROI 115. In various embodiments,ultrasound probe 105 is capable of emittingultrasound energy 120 at variable depths inROI 115, such as, for example, the depths described herein.Ultrasound probe 105 is capable of emitting ultrasound energy as a single frequency, variable frequencies, or a plurality of frequencies, such as, for example, the frequency ranges described herein.Ultrasound probe 105 is capable of emitting ultrasound energy that is weakly focused.Ultrasound probe 105 is capable of emittingultrasound energy 120 for variable time periods or to pulse the emission over time, such as, for example, those time intervals described herein.Ultrasound probe 105 is capable of providing various energy levels of ultrasound energy, such as, for example, the energy levels described herein. -
Ultrasound probe 105 may be individual hand-held device, or may be part of a treatment system. Theultrasound probe 105 can provide both ultrasound energy and imaging ultrasound energy. However,ultrasound probe 105 may provide only ultrasound energy.Ultrasound probe 105 may comprise a therapeutic transducer and a separate imaging transducer.Ultrasound probe 105 may comprise a transducer or a transducer array capable of both cosmetic rejuvenation and imaging applications. According an alternative embodiment,ultrasound probe 105 is coupled directly to one of the tissue layers, as opposed to targetedskin surface 104 to treat the tissue layer. - In various embodiments,
ultrasound probe 105 may be used formethod 100 ormethod 150. In various embodiments,method 100 ormethod 150 can be implemented using any or all of the elements illustrated inFIG. 3 . As will be appreciated by those skilled in the art, at least a portion ofmethod 100 or a variation ofmethod 100 can be implemented using any or all of the elements illustrated inFIG. 3 . Furthermore, at least a portion ofmethod 150 or a variation ofmethod 150 can be implemented using any or all of the elements illustrated inFIG. 3 . - With reference to
FIG. 4 , an embodiment oftransduction element 125 is illustrated. Transduction element 125B comprisesfirst transduction element 121 andsecond transduction element 122. In some embodiments,first transduction element 121 andsecond transduction element 122 can have the same focus, which can be mechanical focus, electronic focus, or combinations thereof. In some embodiments,first transduction element 121 andsecond transduction element 122 can have different focal points. In some embodiments,first transduction element 121 andsecond transduction element 122 can be multiple elements of the same therapy transducer, sectioned for different f-numbers. - In some embodiments,
first transduction element 121 is operable to focusultrasound energy 148 to targetzone 142 andsecond transduction element 122 is operable to focusultrasound energy 108 tosecond target zone 142A. Alternatively,first transduction element 121 andsecond transduction element 122 may be controlled in a combination of different frequencies, different time periods, and different power levels to focusultrasound energy 148 to at least one oftarget zone 142 andsecond target zone 142A. - Now with reference to
FIGS. 5 and 6 , an embodiment of aprobe 105 comprising anannular array 131 of transduction elements is illustrated.Annular array 131 can be controlled to weakly focusedultrasound energy 133 intosubcutaneous layer 127. The weakly focusedultrasound energy 133 is controlled to create aconformal region 133 of elevated temperature in thesubcutaneous layer 127. Theconformal region 133 of elevated temperature can be directed to one or more layers of skin or one or more layers ofsubcutaneous tissue 127. - For example, the
conformal region 133 of elevated temperature may be directed to span fromskin surface 104 to theepidermal layer 102. For example, theconformal region 133 of elevated temperature may be directed to span fromskin surface 104, through theepidermal layer 102, to at least a portion of thedermal layer 106. For example, theconformal region 133 of elevated temperature may include targetedskin surface 104,epidermal layer 102,dermis layer 106, andfat layer 108. For example, theconformal region 133 of elevated temperature may include targetedskin surface 104,epidermal layer 102,dermis layer 106,fat layer 108, andSMAS layer 110. For example, theconformal region 133 of elevated temperature may include targetedskin surface 104,epidermal layer 102,dermis layer 106,fat layer 108, andSMAS layer 110. For example, theconformal region 133 of elevated temperature may include targetedskin surface 104,epidermal layer 102,dermis layer 106,fat layer 108,SMAS layer 110 andmuscle layer 112. - Alternately, the
conformal region 133 of elevated temperature may includeepidermal layer 102,dermis layer 106,fat layer 108,SMAS layer 110 andmuscle layer 112. Theconformal region 133 of elevated temperature may includedermis layer 106,fat layer 108,SMAS layer 110 andmuscle layer 112. Theconformal region 133 of elevated temperature may includeSMAS layer 110 andmuscle layer 112. Theconformal region 133 of elevated temperature may include themuscle layer 112. - In another example, the
conformal region 133 of elevated temperature may includeepidermal layer 102,dermis layer 106,fat layer 108, andSMAS layer 110. Theconformal region 133 of elevated temperature may includedermis layer 106,fat layer 108, andSMAS layer 110. Theconformal region 133 of elevated temperature may includefat layer 108, andSMAS layer 110. Theconformal region 133 of elevated temperature may includeSMAS layer 110. - In still another example, the
conformal region 133 of elevated temperature may include targetedskin surface 104,epidermal layer 102,dermis layer 106, andfat layer 108. Theconformal region 133 of elevated temperature may include targetedskin surface 104,epidermal layer 102,dermis layer 106, andfat layer 108. Theconformal region 133 of elevated temperature may includedermis layer 106, andfat layer 108. Theconformal region 133 of elevated temperature may include dermis thefat layer 108. For example, theconformal region 133 of elevated temperature may include targetedskin surface 104,epidermal layer 102, anddermis layer 106. Theconformal region 133 of elevated temperature may includeepidermal layer 102, anddermis layer 106. Theconformal region 133 of elevated temperature may include thedermis layer 106. In another example, theconformal region 133 of elevated temperature may include targetedskin surface 104 and theepidermal layer 102. Theconformal region 133 of elevated temperature may include theepidermal layer 102. Theconformal region 133 of elevated temperature may include targetedskin surface 104. In still another example, theconformal region 133 of elevated temperature may include a junction between thedermis layer 106 and theSMAS layer 110. - In
FIGS. 7-11 ,transducer 125 is configured to createconformal region 133 of elevated temperature and secondconformal region 133A, in accordance to various embodiments. In various embodiments,ultrasound probe 105 comprisesenclosure 78 containingtransducer 125 and optionally positionsensor 107.Ultrasound probe 105 can be coupled to targetedskin surface 104.Ultrasound energy transducer 125 to createconformal region 133 of elevated temperature and secondconformal region 133A of elevated temperature insubcutaneous tissue 127. In various embodiments, weakly focusedultrasound energy 131 and second weakly focusedultrasound energy 131A can createconformal region 133 of elevated temperature and secondconformal region 133A. In some embodiments,conformal region 133 of elevated temperature and secondconformal region 133A intersect. As illustrated inFIG. 7 ,transducer 125 is elongated and may comprise a plurality of transduction elements. In this configuration,transducer 125 can createconformal region 133 of elevated temperature and secondconformal region 133A alongdimension 129. In this configuration, probe 105 can provide a cosmetic effect to a larger area of targetedskin surface 104. - As discussed herein,
conformal region 133 of elevated temperature can be directed to one or more layers of skin or one or more layers ofsubcutaneous tissue 127. Accordingly, secondconformal region 133A of elevated temperature can be directed to one or more layers of skin or one or more layers ofsubcutaneous tissue 127, as described herein in regards toconformal region 133 of elevated temperature. In some embodiments, at least a portion bothconformal region 133 of elevated temperature and secondconformal region 133A of elevated temperature are directed to the same layer of combination of layers in thesubcutaneous tissue 127. - Now with reference to
FIG. 12 ,ultrasound probe 105 is illustrated. In various embodiments,ultrasound probe 105 comprisesenclosure 78 containingtransducer 125 and optionally positionsensor 107.Ultrasound probe 105 can be coupled to targetedskin surface 104.Ultrasound energy transducer 125 to createconformal region 133 of elevated temperature and secondconformal region 133A of elevated temperature insubcutaneous tissue 127. In various embodiments, weakly focusedultrasound energy 131 and second weakly focusedultrasound energy 131A can createconformal region 133 of elevated temperature and secondconformal region 133A - In various embodiments,
position sensor 107 may determine adistance 117 between pulses oftherapeutic ultrasound energy 108 to create a plurality ofconformal region 133 of elevated temperature which are evenly spaced or disposed in any spatial configuration in one-, two-, or three-dimensions. Asultrasound probe 105 is moved indirection 130,position sensor 107 determinesdistance 117, regardless of a speed thatultrasound probe 105 is move, at which a pulse ofultrasound energy embodiments ultrasound probe 105 is triggered automatically via a timer and in combination with aposition sensor 107 to assure motion. - However, in various embodiments,
ultrasound probe 105 comprisesposition sensor 107.Position sensor 107 can be integrated intoultrasound probe 105 or attached toultrasound probe 105. In an exemplary embodiment,position sensor 107 is a motion sensor measuring position ofultrasound probe 105. Such a motion sensor can calculate distance traveled alongskin surface 104. Such a motion sensor may determine a speed of movement ofultrasound probe 105 alongskin surface 104 and determine if the speed is accurate for the cosmetic procedure that is elected. For example if the speed is too fast, motion sensor can signal an indicator to slow the speed and/or can signaltransducer 125 to stop emittingultrasound energy - In various embodiments,
position sensor 107 can include a laser position sensor. For example,position sensor 107 can track position like a computer mouse that uses a laser sensor as opposed to an older version of a mouse with a roller ball.Position sensor 107 can communicate position data versus time to a display to track a position ofultrasound probe 105, such as, for example, overlaid on an image of ROI, overlaid on an image ofskin surface 104, as referenced to geotagged features, as reference to targeted location, as referenced to a prior procedures, and combinations thereof. In an exemplary a treatment plan can include a movement pattern ofultrasound probe 105. Such a movement pattern can be displayed and theposition sensor 107 can track a position ofultrasound probe 105 during a cosmetic procedure as compared to the movement pattern.Tracking ultrasound probe 105 with position sensor and comparing the tracked movement to a predetermined movement may be useful as a training tool. In an exemplary embodiment, laser position sensor can geotag a feature onskin surface 104. - In various embodiments,
position sensor 107 may determine adistance 117 between pulses oftherapeutic ultrasound energy 108 to create a plurality of lesions 25 which are evenly spaced or disposed in any spatial configuration in one-, two-, or three-dimensions. Asultrasound probe 105 is moved indirection 130,position sensor 107 determinesdistance 117, regardless of a speed thatultrasound probe 105 is move, at which a pulse oftherapeutic ultrasound energy 108 is to be emitted in to ROI. In variousembodiments ultrasound probe 105 is triggered automatically via a timer and in combination with aposition sensor 107 to assure motion. -
Position sensor 107 may be located behind a transducer, in front of a transducer array, or integrated into a transducer array.Ultrasound probe 105 may comprise more than oneposition sensor 107, such as, for example, a laser position sensor and a motion sensor, or a laser position sensor and a visual device, or a motion sensor and a visual device, or a laser position sensor, a motion sensor, and a visual device. Additional embodiments ofposition sensor 107 may be found in U.S. Pat. No. 7,142,905, entitled “Visual Imaging System for Ultrasonic Probe” issued Nov. 28, 2006, and U.S. Pat. No. 6,540,679, entitled “Visual Imaging System for Ultrasonic Probe” issued Apr. 1, 2003, both of which are incorporated by reference. -
Position sensor 107 can be integrated intoultrasound probe 105 or attached toultrasound probe 105. In an exemplary embodiment,position sensor 107 is an optical sensor measuring 1-D, 2-D, or 3-D movement 130 ofultrasound probe 105 versus time while probe travels alongskin surface 104. Such a position sensor may controlconformal region 133 of elevated temperature sequence directly, by using position information in the treatment system to trigger emission ofultrasound energy ultrasound probe 105 reaches a fixed or pre-determined range away from thelast ablation zone 112. Speed of motion can be used to controltherapeutic ultrasound energy 108. For example, if the motion is too fast information can be provided to the user to slow down and/or energy can be dynamically adjusted within limits. Position information may also be used to suppress energy if crossing over the same spatial position, if desired. Such aposition sensor 107 may also determine ifultrasound probe 105 is coupled toskin surface 104, to safely control energy delivery and provide information to users. - With reference to
FIG. 13 , a hand held ultrasound probe, according to various embodiments of the present invention, is illustrated. In various embodiments,ultrasound probe 105 comprisestransducer 125, as described herein, and may be controlled and operated by a hand-held format control system. An external battery charger can be used with rechargeable-type batteries 84 or thebatteries 84 can be single-use disposable types, such as M-sized cells. Power converters produce voltages for powering a driver/feedback circuit with tuning network drivingtransducer array 100. -
Ultrasound probe 105 is coupled to targetedskin surface 104 via one or more tips 88, which can be composed of at least one of a solid media, semi-solid, such as, for example, a gelatinous media, and liquid media equivalent to an acoustic coupling agent contained within a housing in tip. Tip 88 is coupled to targetedskin surface 104 with an acoustic coupling agent. In some embodiments,ultrasound probe 105 comprisesposition sensor 107, as described herein. In some embodiments, tip 88 may comprisetransducer 125. In such embodiments, the tip 88 andtransducer 125 can be disposable and replaceable. - In addition, a microcontroller and timing circuits with associated software and algorithms provide control and user interfacing via a display or LED-
type indicators 83, and other input/output controls 82, such as switches and audio devices. A storage element, such as an Electrically Erasable Programmable Read-Only Memory (“EEPROM”), secure EEPROM, tamper-proof EEPROM, or similar device can hold calibration and usage data. A motion mechanism with feedback can be controlled to scan thetransducer 125 in a linear pattern or a two-dimensional pattern or over a varied depth. Other feedback controls comprise capacitive, acoustic, or other coupling detection means, limiting controls, and thermal sensor. EEPROM can be coupled with at least one of tip 88,transducer array 100, thermal sensor, coupling detector, and tuning network. Data from EEPROM can be collected in controller 144 and connected to treatment data. - In an exemplary embodiment, data from EEPROM can be downloaded to a user's computer via any interface type, such as, for example, a USB interface, a RS 232 interface, a IEEE interface, a fire-wire interface, a blue tooth interface, an infrared interface, a 802.1 interface, via the web, and the like. Downloadable data can include hours of use, frequency during use, power levels, depths, codes from tips used, error codes, user ID, and other such data. The data can be parsed by user ID so more than one user can track user data. Similarly, EEPROM can be interfaced, using any of the methods or devices described herein, to a computer or the web to receive software updates. Still further, EEPROM can be interfaced, using any of the methods or devices described herein, to a computer or the web for at least one of diagnosis, trouble shooting, service, repair, and combinations thereof.
- As illustrated in
FIG. 13 ,ultrasound probe 105 can be in communication withwireless device 200 viawireless interface 204. Typically,wireless device 200 hasdisplay 206 and a user interface such as, for example, a keyboard. Examples ofwireless device 200 can include but are not limited to: personal data assistants (“PDA”), cell phone, iPhone, iPad, computer, laptop, netbook, or any other such device now known or developed in the future. Examples ofwireless interface 204 include but are not limited to any wireless interface described herein and any such wireless interface now known or developed in the future. Accordingly,ultrasound probe 105 comprises any hardware, such as, for example, electronics, antenna, and the like, as well as, any software that may be used to communicate viawireless interface 204. - In various embodiments,
device 200 can display an image generated byhandheld probe 105. In various embodiments,device 200 can controlhandheld ultrasound probe 105. In various embodiments,device 200 can store data generated byhandheld ultrasound probe 105. - In various embodiments,
transducer 125, optionally andimaging transducer array 110, and optionally,position sensor 107 can held withinenclosure 78. In an exemplary embodiment,enclosure 78 is designed for comfort and control while used in an operator's hand.Enclosure 78 may also contain various electronics, such as, for example, EEPROM, interface connection, motion mechanisms, and/or ram for holding programs, and combinations thereof. -
Ultrasound energy transducer 125 may be spatially and/or temporally controlled at least in part by changing the spatial parameters oftransducer 125, such as the placement, distance, treatment depth andtransducer 125 structure, as well as by changing the temporal parameters oftransducer 125, such as the frequency, drive amplitude, and timing, with such control handled via controller in hand-held assembly ofultrasound probe 105. In various embodiments,ultrasound probe 105 comprises atransducer 125 capable of emittingultrasound energy -
Ultrasound energy 131 creates createconformal region 133 of elevated temperature in a tissue layer, at which a temperature of tissue is raised by 10° C. to 15° C., or is raised to a temperature in the range form about 4° C. to about 55° C., or from about 43° C. to about 48° C., or below a threshold of ablation of the tissue. - In various embodiments, the ultrasound energy level is in a range of about 0.1 joules to about 500 joules in order to create an ablative lesion. However, the
ultrasound energy 108 level can be in a range of from about 0.1 joules to about 100 joules, or from about 1 joules to about 50 joules, or from about 0.1 joules to about 10 joules, or from about 50 joules to about 100 joules, or from about 100 joules to about 500 joules, or from about 50 joules to about 250 joules. - Further, the amount of time ultrasound energy is applied at these levels to create a lesion varies in the range from approximately 1 millisecond to several minutes. However, a range can be from about 1 millisecond to about 5 minutes, or from about 1 millisecond to about 1 minute, or from about 1 millisecond to about 30 seconds, or from about 1 millisecond to about 10 seconds, or from about 1 millisecond to about 1 second, or from about 1 millisecond to about 0.1 seconds, or about 0.1 seconds to about 10 seconds, or about 0.1 seconds to about 1 second, or from about 1 millisecond to about 200 milliseconds, or from about 1 millisecond to about 0.5 seconds.
- The frequency of the ultrasound energy can be in a range from about 0.1 MHz to about 100 MHz, or from about 0.1 MHz to about 50 MHz, or from about 1 MHz to about 50 MHz or about 0.1 MHz to about 30 MHz, or from about 10 MHz to about 30 MHz, or from about 0.1 MHz to about 20 MHz, or from about 11 MHz to about 20 MHz, or from about 20 MHz to about 30 MHz.
- The frequency of the ultrasound energy can be in a range from about 1 MHz to about 12 MHz, or from about 5 MHz to about 15 MHz, or from about 2 MHz to about 12 MHz or from about 3 MHz to about 7 MHz.
- In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 0 mm to about 150 mm, or from about 0 mm to about 100 mm, or from about 0 mm to about 50 mm, or from about 0 mm to about 30 mm, or from about 0 mm to about 20 mm, or from about 0 mm to about 10 mm, or from about 0 mm to about 5 mm. In some embodiments, the ultrasound energy can be emitted to depths below a skin surface in a range from about 5 mm to about 150 mm, or from about 5 mm to about 100 mm, or from about 5 mm to about 50 mm, or from about 5 mm to about 30 mm, or from about 5 mm to about 20 mm, or from about 5 mm to about 10 nm. In some embodiments, the ultrasound energy can be emitted to depths below a skin surface in a range from about 10 mm to about 150 mm, or from about 10 mm to about 100 mm, or from about 10 mm to about 50 mm, or from about 10 mm to about 30 mm, or from about 10 mm to about 20 mm, or from about 0 mm to about 10 mm.
- In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in the range from about 20 mm to about 150 mm, or from about 20 mm to about 100 mm, or from about 20 mm to about 50 mm, or from about 20 mm to about 30 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 30 mm to about 150 mm, or from about 30 mm to about 100 mm, or from about 30 mm to about 50 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 50 mm to about 150 mm, or from about 50 mm to about 100 mm. In some embodiments, the ultrasound energy can be emitted to depths at or below a skin surface in a range from about 20 mm to about 60 mm, or from about 40 mm to about 80 mm, or from about 10 mm to about 40 mm, or from about 5 mm to about 40 mm, or from about 0 mm to about 40 mm, or from about 10 mm to about 30 mm, or from about 5 mm to about 30 mm, or from about 0 mm to about 30 mm.
- In various embodiments, the
probe 105 comprises atransducer 125 operating frequency range of 2-12 MHz or 4-8 MHz or 6 MHz. In various embodiments, theprobe 105 comprises atransducer 125 with an operating power of about 1 watt. In various embodiments, theprobe 105 comprises atransducer 125 having an operating intensity range: 10-500 W/cm2 or 20-100 W/cm2. In various embodiments, theprobe 105 comprises atransducer 125 that is a consumable transducer. - Further, medicant and/or cosmeceutical, as described above, can include a drug, a medicine, or a protein, and combinations thereof. Medicant and/or cosmeceutical can also include a vaccine, blood or blood component, allergenic, somatic cell, gene therapy, tissue, recombinant therapeutic protein, or living cells that are used as therapeutics to treat diseases or as actives to produce a cosmetic effect. Medicant and/or cosmeceutical can also include a biologic, such as for example a recombinant DNA therapy, synthetic growth hormone, monoclonal antibodies, or receptor constructs.
- Medicant and/or cosmeceutical can also include adsorbent chemicals, such as zeolites, and other hemostatic agents are used in sealing severe injuries quickly. Thrombin and fibrin glue are used surgically to treat bleeding and to thrombose aneurysms. Medicant and/or cosmeceutical can include Desmopressin is used to improve platelet function by activating arginine vasopressin receptor 1A. Medicant and/or cosmeceutical can include coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in patients with impaired coagulation factor synthesis or increased consumption. Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly-used coagulation factor products. Recombinant activated human factor VII can be used in the treatment of major bleeding. Medicant and/or cosmeceutical can include tranexamic acid and aminocaproic acid, can inhibit fibrinolysis, and lead to a de facto reduced bleeding rate. In addition, medicant and/or cosmeceutical can include steroids like the glucocorticoid cortisol. A medicant and/or cosmeceutical can include can include compounds as alpha lipoic Acid, DMAE, vitamin C ester, tocotrienols, and phospholipids.
- Medicant 202 can be a pharmaceutical compound such as for example, cortisone, Etanercept, Abatacept, Adalimumrab, or Infliximab. Medicant 202 can include platelet-rich plasma (PRP), mesenchymal stem cells, or growth factors. For example, PRP is typically a fraction of blood that has been centrifuged. The PRP is then used for stimulating healing of the injury. The PRP typically contains thrombocytes (platelets) and cytokines (growth factors). The PRP may also contain thrombin and may contain fibenogen, which when combined can form fibrin glue. Medicant 202 can be a prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma, which are commonly-used coagulation factor products. Medicant 202 can be a recombinant activated human factor VII, which can be used in the treatment of major bleeding. Medicant 202 can include tranexamic acid and aminocaproic acid, can inhibit fibrinolysis, and lead to a de facto reduced bleeding rate. In some embodiments, medicant can be Botox.
- A medicant and/or cosmeceutical can include platelet-rich plasma (PRP), mesenchymal stem cells, or growth factors. For example, PRP is typically a fraction of blood that has been centrifuged. The PRP is then used for stimulating healing of the injury. The PRP typically contains thrombocytes (platelets) and cytokines (growth factors). The PRP may also contain thrombin and may contain fibenogen, which when combined can form fibrin glue.
- The following patents and patent applications are incorporated by reference: US Patent Application Publication No. 20050256406, entitled “Method and System for Controlled Scanning, Imaging, and/or Therapy” published Nov. 17, 2005; US Patent Application Publication No. 20060058664, entitled “System and Method for Variable Depth Ultrasound Treatment” published Mar. 16, 2006; US Patent Application Publication No. 20060084891, entitled Method and System for Ultra-High Frequency Ultrasound Treatment” published Apr. 20, 2006; U.S. Pat. No. 7,530,958, entitled “Method and System for Combined Ultrasound Treatment” issued May 12, 2009; US Patent Application Publication No. 2008071255, entitled “Method and System for Treating Muscle, Tendon, Ligament, and Cartilage Tissue” published Mar. 20, 2008; U.S. Pat. No. 6,623,430, entitled “Method and Apparatus for Safely Delivering Medicants to a Region of Tissue Using Imaging, Therapy, and Temperature Monitoring Ultrasonice System, issued Sep. 23, 2003; U.S. Pat. No. 7,571,336, entitled “Method and System for Enhancing Safety with Medical Peripheral Device by Monitoring if Host Computer is AC Powered” issued Aug. 4, 2009; US Patent Application Publication No. 20080281255, entitled “Methods and Systems for Modulating Medicants Using Acoustic Energy” published Nov. 13, 2008; US Patent Application Publication No. 20060116671, entitled “Method and System for Controlled Thermal Injury of Human Superficial Tissue,” published Jun. 1, 2006; US Patent Application Publication No. 20060111744, entitled “Method and System for Treatment of Sweat Glands,” published May 25, 2006; US Patent Application Publication No. 20080294073, entitled “Method and System for Non-Ablative Acne Treatment and Prevention,” published Oct. 8, 2009; U.S. Pat. No. 8,133,180, entitled “Method and System for Treating Cellulite,” issued Mar. 13, 2012; U.S. Pat. No. 8,066,641, entitled “Method and System for Photoaged Tissue,” issued Nov. 29, 2011; U.S. Pat. No. 7,491,171, entitled “Method and System for Treating Acne and Sebaceous Glands,” issued Feb. 17, 2009; U.S. Pat. No. 7,615,016, entitled “Method and System for Treating Stretch Marks,” issued Nov. 10, 2009; and U.S. Pat. No. 7,530,356, entitled “Method and System for Noninvasive Mastopexy,” issued May 12, 2009.
- It is believed that the disclosure set forth above encompasses at least one distinct invention with independent utility. While the invention has been disclosed in the exemplary forms, the specific embodiments thereof as disclosed and illustrated herein are not to be considered in a limiting sense as numerous variations are possible. The subject matter of the inventions includes all novel and non-obvious combinations and sub combinations of the various elements, features, functions and/or properties disclosed herein.
- Various embodiments and the examples described herein are exemplary and not intended to be limiting in describing the full scope of compositions and methods of this invention. Equivalent changes, modifications and variations of various embodiments, materials, compositions and methods may be made within the scope of the present invention, with substantially similar results.
Claims (27)
1. A method for treating a surface of skin, the method comprising:
creating a conformal region of elevated temperature;
treating a surface and subsurface of skin simultaneously;
creating a transitional biological effect on the surface of the skin without causing cell death, a scar, or permanent damage to the surface of the skin;
creating a thermal effect to the subsurface of the skin; and
initiating a permanent biological effect to the subsurface of the skin.
2. The method according to claim 1 , further comprising creating an optically visible effect on the surface of the skin.
3. The method according to claim 1 wherein the transitional biological effect can be one of erythema, edema, and a transitional coagulative point.
4. The method according to claim 2 , wherein the optically visible effect on the surface of the skin can be at least one of at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
5. The method according to claim 1 , wherein the permanent biological effect can be at least one of is at least one of stimulating or increase an amount of heat shock proteins, cause white blood cells to promote healing of tissue, accelerating ta wound healing cascade in the subcutaneous tissue, increasing the blood perfusion in the subcutaneous tissue, encouraging collagen growth, increasing the liberation of cytokines, peaking inflammation, partially shrinking collagen, denaturing of proteins in the subcutaneous tissue, and combinations thereof.
6. The method according to claim 1 wherein the permanent biological effect is at least one of creating immediate or delayed cell death, collagen remodeling, disrupting or modifying of biochemical cascades, producing new collagen, stimulating cell growth, stimulating angiogenesis, stimulating a cell permeability response, enhancing delivery of medicants to tissue, and combinations thereof.
7. The method according to claim 1 , further comprising administering a medicant to the surface and the subsurface of the skin.
8. The method according to claim 7 , further comprising activating the medicant in at least one of the surface and the subsurface of the skin with the ultrasound energy at the same frequency or a different frequency.
9. The method according to claim 1 , further comprising delivering a secondary energy to the surface and the subsurface of the skin.
10. The method according to claim 9 , wherein the secondary energy is a photon-based energy.
11. The method according to claim 1 , wherein the optically visible effect to the surface of the skin is a cosmetic effect.
12. A method for improving an appearance of a skin surface, the method comprising:
locating a targeted portion of skin surface;
delivering ultrasound energy to subcutaneous tissue below the skin surface;
producing a biological effect in at least one of the skin surface and the subcutaneous tissue; and
improving the appearance of the targeted portion of the skin surface.
13. The method according to claim 12 , further comprising driving a medicant to the subcutaneous tissue below the skin surface.
14. The method according to claim 13 , further comprising activating the medicant in the region of interest with the ultrasound energy at the same frequency or a different frequency.
15. The method according to claim 12 , further comprising driving a cosmeceutical to the subcutaneous tissue below the skin surface.
16. The method according to claim 12 , further comprising delivering a secondary energy to the subcutaneous tissue below the skin surface.
17. The method according to claim 16 , wherein the secondary energy is a photon-based energy.
18. The method according to claim 16 , wherein the secondary energy is radio frequency based energy.
19. The method according to claim 12 , wherein the biological effect is at least one of stimulating or increase an amount of heat shock proteins, cause white blood cells to promote healing of a portion of the subcutaneous tissue, accelerating a wound healing cascade in the subcutaneous tissue, increasing the blood perfusion in the subcutaneous tissue, encouraging collagen growth in the subcutaneous tissue, increasing the liberation of cytokines within the subcutaneous layer, peaking inflammation in the subcutaneous tissue, partially shrinking collagen in a portion of the subcutaneous tissue, denaturing of proteins in the subcutaneous tissue, and combinations thereof
20. The method according to claim 12 , wherein the biological effect is at least one of creating immediate or delayed cell death in the subcutaneous tissue, collagen remodeling in the subcutaneous tissue, disrupting or modifying of biochemical cascades in at least one of the skin surface and the subcutaneous tissue, producing new collagen in the subcutaneous tissue, stimulating cell growth in the subcutaneous tissue, stimulating angiogenesis, stimulating a cell permeability response, enhancing delivery of medicants to in the subcutaneous tissue, and combinations thereof.
21. The method according to claim 12 , wherein the improving the appearance of the targeted portion of the skin surface comprises at least one of increasing skin elasticity, reducing skin oiliness, reducing skin pore size, smoothing skin texture, reducing hyperpigmentation, treating and/or preventing acne, reducing a blemish, reducing an appearance of spider veins and/or rosacea, reducing an appearance of scars, reducing an appearance of stretch marks, rejuvenating skin, increasing collagen in the subcutaneous tissue, tightening of sagging sink, rejuvenating photoaged skin, increasing a thickness of a dermal layer, reducing a wrinkle on the skin surface, generating new tissue in the subcutaneous layer, and combinations thereof.
22. A system for improving the appearance of a skin surface, the system comprising:
a hand-held probe comprising:
an ultrasound transducer;
an indicator display;
at least one input/output control;
a position sensor; and
a rechargeable battery configured to power the hand-held probe;
a controller configured to control the hand-held probe; and
a wireless interface configured to couple communication between the controller and the hand-held probe.
23. The system according to claim 22 , wherein the controller is at least one of a personal data assistant, a cell phone, an iPhone, an iPad, a computer, a laptop, and a netbook.
24. The system according to claim 22 , wherein the transducer is configured as a 2 dimensional linear array.
25. The system according to claim 22 , wherein the ultrasound transducer is configured to simultaneously create a first conformal region of elevated temperature and second conformal region of elevated temperature in subcutaneous tissue.
26. The system according to claim 24 , wherein the first conformal region of elevated temperature and second conformal region of elevated temperature intersect in the subcutaneous tissue.
27. The system according to claim 24 , wherein the first conformal region of elevated temperature and second conformal region of elevated temperature are positioned perpendicular to each other in the subcutaneous tissue.
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US20080214966A1 (en) * | 2004-10-06 | 2008-09-04 | Slayton Michael H | Method and system for noninvasive face lifts and deep tissue tightening |
US20090182231A1 (en) * | 2004-10-06 | 2009-07-16 | Guided Therapy Systems, L.L.C. | Method and system for treating acne and sebaceous glands |
US20100022922A1 (en) * | 2004-10-06 | 2010-01-28 | Guided Therapy Systems, L.L.C. | Method and system for treating stretch marks |
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US20140290368A1 (en) * | 2013-03-28 | 2014-10-02 | Siemens Energy, Inc. | Method and apparatus for remote position tracking of an industrial ultrasound imaging probe |
US8857438B2 (en) | 2010-11-08 | 2014-10-14 | Ulthera, Inc. | Devices and methods for acoustic shielding |
US8858471B2 (en) | 2011-07-10 | 2014-10-14 | Guided Therapy Systems, Llc | Methods and systems for ultrasound treatment |
US8868958B2 (en) | 2005-04-25 | 2014-10-21 | Ardent Sound, Inc | Method and system for enhancing computer peripheral safety |
US8915853B2 (en) | 2004-10-06 | 2014-12-23 | Guided Therapy Systems, Llc | Methods for face and neck lifts |
US8932224B2 (en) | 2004-10-06 | 2015-01-13 | Guided Therapy Systems, Llc | Energy based hyperhidrosis treatment |
US9011336B2 (en) | 2004-09-16 | 2015-04-21 | Guided Therapy Systems, Llc | Method and system for combined energy therapy profile |
US9011337B2 (en) | 2011-07-11 | 2015-04-21 | Guided Therapy Systems, Llc | Systems and methods for monitoring and controlling ultrasound power output and stability |
US9039617B2 (en) | 2009-11-24 | 2015-05-26 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
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US9263663B2 (en) | 2012-04-13 | 2016-02-16 | Ardent Sound, Inc. | Method of making thick film transducer arrays |
US9272162B2 (en) | 1997-10-14 | 2016-03-01 | Guided Therapy Systems, Llc | Imaging, therapy, and temperature monitoring ultrasonic method |
US20160067526A1 (en) * | 2014-09-04 | 2016-03-10 | National Yang-Ming University | Method for treating and/or preventing neurodegenerative diseases by using low-intensity pulsed ultrasound (LIPUS) |
US9504446B2 (en) | 2010-08-02 | 2016-11-29 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
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US20170001043A1 (en) * | 2013-12-23 | 2017-01-05 | Theraclion Sa | Device for treatment of a tissue and method of preparation of an image of an image-guided device for treatment of a tissue |
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US9907535B2 (en) | 2000-12-28 | 2018-03-06 | Ardent Sound, Inc. | Visual imaging system for ultrasonic probe |
US10039938B2 (en) | 2004-09-16 | 2018-08-07 | Guided Therapy Systems, Llc | System and method for variable depth ultrasound treatment |
US10112119B2 (en) * | 2015-11-09 | 2018-10-30 | Disney Enterprises, Inc. | Method for modifying local properties of materials |
US10420960B2 (en) | 2013-03-08 | 2019-09-24 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
US10537304B2 (en) | 2008-06-06 | 2020-01-21 | Ulthera, Inc. | Hand wand for ultrasonic cosmetic treatment and imaging |
US10561862B2 (en) | 2013-03-15 | 2020-02-18 | Guided Therapy Systems, Llc | Ultrasound treatment device and methods of use |
US10603521B2 (en) | 2014-04-18 | 2020-03-31 | Ulthera, Inc. | Band transducer ultrasound therapy |
US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
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US11224895B2 (en) | 2016-01-18 | 2022-01-18 | Ulthera, Inc. | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof |
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US11241218B2 (en) | 2016-08-16 | 2022-02-08 | Ulthera, Inc. | Systems and methods for cosmetic ultrasound treatment of skin |
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US11491342B2 (en) | 2015-07-01 | 2022-11-08 | Btl Medical Solutions A.S. | Magnetic stimulation methods and devices for therapeutic treatments |
KR101643746B1 (en) | 2015-06-12 | 2016-07-29 | 예림엔지니어링 주식회사 | Raser pulse control method for skin treatment |
US20180001107A1 (en) | 2016-07-01 | 2018-01-04 | Btl Holdings Limited | Aesthetic method of biological structure treatment by magnetic field |
US11266850B2 (en) | 2015-07-01 | 2022-03-08 | Btl Healthcare Technologies A.S. | High power time varying magnetic field therapy |
US10695575B1 (en) | 2016-05-10 | 2020-06-30 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US20170007853A1 (en) * | 2015-07-10 | 2017-01-12 | Medtronic, Inc. | Physiological monitoring for ultrasound therapy |
KR101770253B1 (en) | 2015-09-15 | 2017-08-22 | 이일권 | An Apparatus for Caring a Skin Using a Ultrasonic Wave Having a Structure of Multi Frequencies Emitting and a Method for Controlling the Same |
KR101616925B1 (en) * | 2015-10-17 | 2016-04-29 | 고재석 | Bio Activation Control Equipment |
US11253717B2 (en) | 2015-10-29 | 2022-02-22 | Btl Healthcare Technologies A.S. | Aesthetic method of biological structure treatment by magnetic field |
HUE058854T2 (en) | 2016-02-19 | 2022-09-28 | Siwa Corp | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age) |
US10709608B2 (en) | 2016-03-21 | 2020-07-14 | Ojai Retinal Technology, Llc | System and process for prevention of myopia |
CA3057829A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
US11511138B2 (en) | 2016-05-02 | 2022-11-29 | University Of Kansas | Method and apparatus for removing microvessels |
US11464993B2 (en) | 2016-05-03 | 2022-10-11 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US11247039B2 (en) | 2016-05-03 | 2022-02-15 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US9861410B2 (en) | 2016-05-06 | 2018-01-09 | Medos International Sarl | Methods, devices, and systems for blood flow |
US11534619B2 (en) | 2016-05-10 | 2022-12-27 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US10583287B2 (en) | 2016-05-23 | 2020-03-10 | Btl Medical Technologies S.R.O. | Systems and methods for tissue treatment |
WO2017212489A2 (en) * | 2016-06-06 | 2017-12-14 | Archimedus Medical Ltd. | Ultrasound transducer and system |
WO2017222535A1 (en) | 2016-06-23 | 2017-12-28 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
US10556122B1 (en) | 2016-07-01 | 2020-02-11 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
CN110691628A (en) * | 2017-03-30 | 2020-01-14 | 国立大学法人东北大学 | Device for treating dementia, method for operating the device, and program |
EP3609923A1 (en) | 2017-04-13 | 2020-02-19 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
WO2019099068A1 (en) * | 2017-11-15 | 2019-05-23 | Ojai Retinal Technology, Llc | Process and system for utilizing energy to treat biological tissue |
JP7116944B2 (en) | 2017-12-20 | 2022-08-12 | 国立研究開発法人量子科学技術研究開発機構 | MEDICAL DEVICE, METHOD OF CONTROLLING MEDICAL DEVICE, AND PROGRAM |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
WO2019177654A1 (en) * | 2018-03-12 | 2019-09-19 | Ojai Retinal Technology, Llc | System and process of utilizing energy for treating biological tissue |
US11260249B2 (en) * | 2018-07-19 | 2022-03-01 | Sonablate Corp. | System, apparatus and method for high intensity focused ultrasound and tissue healing activation |
PL4066887T3 (en) | 2019-04-11 | 2024-03-04 | Btl Medical Solutions A.S. | Devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy |
KR20220007884A (en) | 2019-05-09 | 2022-01-19 | 자이러스 에이씨엠아이, 인코포레이티드 디.비.에이. 올림푸스 써지컬 테크놀러지스 아메리카 | Electrosurgical systems and methods |
US20220313547A1 (en) * | 2019-08-14 | 2022-10-06 | Taket Llc | Vibration-generating device |
CN111150424A (en) * | 2020-01-16 | 2020-05-15 | 黄晶 | Imaging and intervention integrated acoustic resonance system |
KR102378699B1 (en) * | 2020-01-30 | 2022-03-29 | 공주대학교 산학협력단 | Variable applicator |
KR20210101481A (en) | 2020-02-10 | 2021-08-19 | 한국과학기술연구원 | A device for removing senescent cells comprising an ultrasound output unit |
KR20230000081U (en) | 2020-05-04 | 2023-01-10 | 비티엘 헬쓰케어 테크놀로지스 에이.에스. | Device and method for unattended treatment of patients |
US11878167B2 (en) | 2020-05-04 | 2024-01-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
CA3176245A1 (en) * | 2020-09-14 | 2022-03-17 | Ginkgo Bioworks, Inc. | Use of bone morphogenetic proteins and their receptors for aesthetics and cosmetics |
US11896816B2 (en) | 2021-11-03 | 2024-02-13 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
Family Cites Families (724)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2427348A (en) | 1941-08-19 | 1947-09-16 | Bell Telephone Labor Inc | Piezoelectric vibrator |
FR2190364B1 (en) | 1972-07-04 | 1975-06-13 | Patru Marcel | |
FR2214378A5 (en) | 1973-01-16 | 1974-08-09 | Commissariat Energie Atomique | |
FR2254030B1 (en) | 1973-12-10 | 1977-08-19 | Philips Massiot Mat Medic | |
US3965455A (en) | 1974-04-25 | 1976-06-22 | The United States Of America As Represented By The Secretary Of The Navy | Focused arc beam transducer-reflector |
US4059098A (en) | 1975-07-21 | 1977-11-22 | Stanford Research Institute | Flexible ultrasound coupling system |
AT353506B (en) | 1976-10-19 | 1979-11-26 | List Hans | PIEZOELECTRIC RESONATOR |
JPS5353393A (en) | 1976-10-25 | 1978-05-15 | Matsushita Electric Ind Co Ltd | Ultrasonic probe |
US4213344A (en) | 1978-10-16 | 1980-07-22 | Krautkramer-Branson, Incorporated | Method and apparatus for providing dynamic focussing and beam steering in an ultrasonic apparatus |
US4211949A (en) | 1978-11-08 | 1980-07-08 | General Electric Company | Wear plate for piezoelectric ultrasonic transducer arrays |
US4211948A (en) | 1978-11-08 | 1980-07-08 | General Electric Company | Front surface matched piezoelectric ultrasonic transducer array with wide field of view |
US4276491A (en) | 1979-10-02 | 1981-06-30 | Ausonics Pty. Limited | Focusing piezoelectric ultrasonic medical diagnostic system |
US4343301A (en) | 1979-10-04 | 1982-08-10 | Robert Indech | Subcutaneous neural stimulation or local tissue destruction |
US4325381A (en) | 1979-11-21 | 1982-04-20 | New York Institute Of Technology | Ultrasonic scanning head with reduced geometrical distortion |
JPS5686121A (en) | 1979-12-14 | 1981-07-13 | Teijin Ltd | Antitumor proten complex and its preparation |
US4315514A (en) | 1980-05-08 | 1982-02-16 | William Drewes | Method and apparatus for selective cell destruction |
US4381787A (en) | 1980-08-15 | 1983-05-03 | Technicare Corporation | Ultrasound imaging system combining static B-scan and real-time sector scanning capability |
US4372296A (en) | 1980-11-26 | 1983-02-08 | Fahim Mostafa S | Treatment of acne and skin disorders and compositions therefor |
JPS6336171Y2 (en) | 1981-03-12 | 1988-09-26 | ||
US4484569A (en) | 1981-03-13 | 1984-11-27 | Riverside Research Institute | Ultrasonic diagnostic and therapeutic transducer assembly and method for using |
US4381007A (en) | 1981-04-30 | 1983-04-26 | The United States Of America As Represented By The United States Department Of Energy | Multipolar corneal-shaping electrode with flexible removable skirt |
EP0068961A3 (en) | 1981-06-26 | 1983-02-02 | Thomson-Csf | Apparatus for the local heating of biological tissue |
US4409839A (en) | 1981-07-01 | 1983-10-18 | Siemens Ag | Ultrasound camera |
US4397314A (en) | 1981-08-03 | 1983-08-09 | Clini-Therm Corporation | Method and apparatus for controlling and optimizing the heating pattern for a hyperthermia system |
US4441486A (en) | 1981-10-27 | 1984-04-10 | Board Of Trustees Of Leland Stanford Jr. University | Hyperthermia system |
DE3300121A1 (en) | 1982-01-07 | 1983-07-14 | Technicare Corp., 80112 Englewood, Col. | METHOD AND DEVICE FOR IMAGING AND THERMALLY TREATING TISSUE BY MEANS OF ULTRASOUND |
US4528979A (en) | 1982-03-18 | 1985-07-16 | Kievsky Nauchno-Issledovatelsky Institut Otolaringologii Imeni Professora A.S. Kolomiiobenka | Cryo-ultrasonic surgical instrument |
US4431008A (en) | 1982-06-24 | 1984-02-14 | Wanner James F | Ultrasonic measurement system using a perturbing field, multiple sense beams and receivers |
US4534221A (en) | 1982-09-27 | 1985-08-13 | Technicare Corporation | Ultrasonic diagnostic imaging systems for varying depths of field |
US4507582A (en) | 1982-09-29 | 1985-03-26 | New York Institute Of Technology | Matching region for damped piezoelectric ultrasonic apparatus |
US4452084A (en) | 1982-10-25 | 1984-06-05 | Sri International | Inherent delay line ultrasonic transducer and systems |
DE3374522D1 (en) | 1982-10-26 | 1987-12-23 | University Of Aberdeen | |
US4513749A (en) | 1982-11-18 | 1985-04-30 | Board Of Trustees Of Leland Stanford University | Three-dimensional temperature probe |
US4527550A (en) | 1983-01-28 | 1985-07-09 | The United States Of America As Represented By The Department Of Health And Human Services | Helical coil for diathermy apparatus |
JPH064074B2 (en) | 1983-02-14 | 1994-01-19 | 株式会社日立製作所 | Ultrasonic diagnostic device and sound velocity measuring method using the same |
FR2543437B1 (en) | 1983-03-30 | 1987-07-10 | Duraffourd Alain | COMPOSITION FOR REGENERATING COLLAGEN OF CONNECTIVE TISSUE OF THE SKIN AND METHOD FOR PREPARING SAME |
US4900540A (en) | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
EP0129878B1 (en) | 1983-06-23 | 1989-01-11 | Matsushita Electric Industrial Co., Ltd. | Ultrasonic probe having dual-motion transducer |
FR2551611B1 (en) | 1983-08-31 | 1986-10-24 | Labo Electronique Physique | NOVEL ULTRASONIC TRANSDUCER STRUCTURE AND ULTRASONIC ECHOGRAPHY MEDIA EXAMINATION APPARATUS COMPRISING SUCH A STRUCTURE |
US4601296A (en) | 1983-10-07 | 1986-07-22 | Yeda Research And Development Co., Ltd. | Hyperthermia apparatus |
US5143074A (en) | 1983-12-14 | 1992-09-01 | Edap International | Ultrasonic treatment device using a focussing and oscillating piezoelectric element |
US5150711A (en) | 1983-12-14 | 1992-09-29 | Edap International, S.A. | Ultra-high-speed extracorporeal ultrasound hyperthermia treatment device |
US4513750A (en) | 1984-02-22 | 1985-04-30 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method for thermal monitoring subcutaneous tissue |
US4567895A (en) | 1984-04-02 | 1986-02-04 | Advanced Technology Laboratories, Inc. | Fully wetted mechanical ultrasound scanhead |
US4620546A (en) | 1984-06-30 | 1986-11-04 | Kabushiki Kaisha Toshiba | Ultrasound hyperthermia apparatus |
DE3447440A1 (en) | 1984-12-27 | 1986-07-03 | Siemens AG, 1000 Berlin und 8000 München | SHOCK SHAFT PIPE FOR THE CRUSHING OF CONCRETE |
DE3501808A1 (en) | 1985-01-21 | 1986-07-24 | Siemens AG, 1000 Berlin und 8000 München | ULTRASONIC CONVERTER |
JPS61209643A (en) | 1985-03-15 | 1986-09-17 | 株式会社東芝 | Ultrasonic diagnostic and medical treatment apparatus |
DE3611669A1 (en) | 1985-04-10 | 1986-10-16 | Hitachi Medical Corp., Tokio/Tokyo | ULTRASONIC CONVERTER |
JPH0678460B2 (en) | 1985-05-01 | 1994-10-05 | 株式会社バイオマテリアル・ユニバース | Porous transparent polyvinyl alcohol gel |
DE3650004T2 (en) | 1985-05-20 | 1995-02-23 | Matsushita Electric Ind Co Ltd | Ultrasound probe. |
US4865042A (en) | 1985-08-16 | 1989-09-12 | Hitachi, Ltd. | Ultrasonic irradiation system |
US5054310A (en) | 1985-09-13 | 1991-10-08 | The California Province Of The Society Of Jesus | Test object and method of measurement of an ultrasonic beam |
US5304169A (en) | 1985-09-27 | 1994-04-19 | Laser Biotech, Inc. | Method for collagen shrinkage |
US4976709A (en) | 1988-12-15 | 1990-12-11 | Sand Bruce J | Method for collagen treatment |
DE3688702T2 (en) | 1985-12-13 | 1993-12-09 | Matsushita Electric Ind Co Ltd | Ultrasound diagnostic device based on changes in an acoustic property. |
JPS6323126A (en) | 1986-02-13 | 1988-01-30 | Bio Material Yunibaasu:Kk | Soft contact lens and its production |
JPS62249644A (en) | 1986-04-22 | 1987-10-30 | 日石三菱株式会社 | Dummy living body structure |
US4875487A (en) | 1986-05-02 | 1989-10-24 | Varian Associates, Inc. | Compressional wave hyperthermia treating method and apparatus |
US4807633A (en) | 1986-05-21 | 1989-02-28 | Indianapolis Center For Advanced Research | Non-invasive tissue thermometry system and method |
US4803625A (en) | 1986-06-30 | 1989-02-07 | Buddy Systems, Inc. | Personal health monitor |
US4867169A (en) | 1986-07-29 | 1989-09-19 | Kaoru Machida | Attachment attached to ultrasound probe for clinical application |
US4801459A (en) | 1986-08-05 | 1989-01-31 | Liburdy Robert P | Technique for drug and chemical delivery |
JPS6336171U (en) | 1986-08-26 | 1988-03-08 | ||
JPS63122923A (en) | 1986-11-13 | 1988-05-26 | Agency Of Ind Science & Technol | Ultrasonic thermometric apparatus |
US4865041A (en) | 1987-02-04 | 1989-09-12 | Siemens Aktiengesellschaft | Lithotripter having an ultrasound locating system integrated therewith |
JPS63220847A (en) | 1987-03-10 | 1988-09-14 | 松下電器産業株式会社 | Ultrasonic probe |
US5178135A (en) | 1987-04-16 | 1993-01-12 | Olympus Optical Co., Ltd. | Therapeutical apparatus of extracorporeal type |
BG46024A1 (en) | 1987-05-19 | 1989-10-16 | Min Na Narodnata Otbrana | Method and device for treatment of bone patology |
US4891043A (en) | 1987-05-28 | 1990-01-02 | Board Of Trustees Of The University Of Illinois | System for selective release of liposome encapsulated material via laser radiation |
JPH0348299Y2 (en) | 1987-05-29 | 1991-10-15 | ||
US4932414A (en) | 1987-11-02 | 1990-06-12 | Cornell Research Foundation, Inc. | System of therapeutic ultrasound and real-time ultrasonic scanning |
US5040537A (en) | 1987-11-24 | 1991-08-20 | Hitachi, Ltd. | Method and apparatus for the measurement and medical treatment using an ultrasonic wave |
US4860732A (en) | 1987-11-25 | 1989-08-29 | Olympus Optical Co., Ltd. | Endoscope apparatus provided with endoscope insertion aid |
US4917096A (en) | 1987-11-25 | 1990-04-17 | Laboratory Equipment, Corp. | Portable ultrasonic probe |
US5163421A (en) | 1988-01-22 | 1992-11-17 | Angiosonics, Inc. | In vivo ultrasonic system with angioplasty and ultrasonic contrast imaging |
US5251127A (en) | 1988-02-01 | 1993-10-05 | Faro Medical Technologies Inc. | Computer-aided surgery apparatus |
US5143063A (en) | 1988-02-09 | 1992-09-01 | Fellner Donald G | Method of removing adipose tissue from the body |
US4858613A (en) | 1988-03-02 | 1989-08-22 | Laboratory Equipment, Corp. | Localization and therapy system for treatment of spatially oriented focal disease |
US4951653A (en) | 1988-03-02 | 1990-08-28 | Laboratory Equipment, Corp. | Ultrasound brain lesioning system |
US4955365A (en) | 1988-03-02 | 1990-09-11 | Laboratory Equipment, Corp. | Localization and therapy system for treatment of spatially oriented focal disease |
US5054470A (en) | 1988-03-02 | 1991-10-08 | Laboratory Equipment, Corp. | Ultrasonic treatment transducer with pressurized acoustic coupling |
US5036855A (en) | 1988-03-02 | 1991-08-06 | Laboratory Equipment, Corp. | Localization and therapy system for treatment of spatially oriented focal disease |
US5665141A (en) * | 1988-03-30 | 1997-09-09 | Arjo Hospital Equipment Ab | Ultrasonic treatment process |
JP2615132B2 (en) | 1988-05-19 | 1997-05-28 | 富士通株式会社 | Ultrasonic probe |
US4947046A (en) | 1988-05-27 | 1990-08-07 | Konica Corporation | Method for preparation of radiographic image conversion panel and radiographic image conversion panel thereby |
US4966953A (en) | 1988-06-02 | 1990-10-30 | Takiron Co., Ltd. | Liquid segment polyurethane gel and couplers for ultrasonic diagnostic probe comprising the same |
US5018508A (en) | 1988-06-03 | 1991-05-28 | Fry Francis J | System and method using chemicals and ultrasound or ultrasound alone to replace more conventional surgery |
US4938217A (en) | 1988-06-21 | 1990-07-03 | Massachusetts Institute Of Technology | Electronically-controlled variable focus ultrasound hyperthermia system |
US4893624A (en) | 1988-06-21 | 1990-01-16 | Massachusetts Institute Of Technology | Diffuse focus ultrasound hyperthermia system |
US4938216A (en) | 1988-06-21 | 1990-07-03 | Massachusetts Institute Of Technology | Mechanically scanned line-focus ultrasound hyperthermia system |
US4896673A (en) | 1988-07-15 | 1990-01-30 | Medstone International, Inc. | Method and apparatus for stone localization using ultrasound imaging |
EP0413028B1 (en) | 1988-08-30 | 1995-07-12 | Fujitsu Limited | Acoustic coupler |
US5159931A (en) | 1988-11-25 | 1992-11-03 | Riccardo Pini | Apparatus for obtaining a three-dimensional reconstruction of anatomic structures through the acquisition of echographic images |
FR2643770B1 (en) | 1989-02-28 | 1991-06-21 | Centre Nat Rech Scient | MICROECHOGRAPHIC ULTRASONIC COLLIMATION PROBE THROUGH A DEFORMABLE SURFACE |
US5088495A (en) | 1989-03-27 | 1992-02-18 | Kabushiki Kaisha Toshiba | Mechanical ultrasonic scanner |
DE3914619A1 (en) | 1989-05-03 | 1990-11-08 | Kontron Elektronik | DEVICE FOR TRANSOESOPHAGEAL ECHOCARDIOGRAPHY |
US6016255A (en) | 1990-11-19 | 2000-01-18 | Dallas Semiconductor Corp. | Portable data carrier mounting system |
US5057104A (en) | 1989-05-30 | 1991-10-15 | Cyrus Chess | Method and apparatus for treating cutaneous vascular lesions |
US5212671A (en) | 1989-06-22 | 1993-05-18 | Terumo Kabushiki Kaisha | Ultrasonic probe having backing material layer of uneven thickness |
US5435311A (en) | 1989-06-27 | 1995-07-25 | Hitachi, Ltd. | Ultrasound therapeutic system |
US5115814A (en) | 1989-08-18 | 1992-05-26 | Intertherapy, Inc. | Intravascular ultrasonic imaging probe and methods of using same |
US4973096A (en) | 1989-08-21 | 1990-11-27 | Joyce Patrick H | Shoe transporting device |
EP0491685A4 (en) | 1989-08-28 | 1993-10-13 | K. Michael Sekins | Lung cancer hyperthermia via ultrasound and/or convection with perfluorocarbon liquids |
US5240003A (en) | 1989-10-16 | 1993-08-31 | Du-Med B.V. | Ultrasonic instrument with a micro motor having stator coils on a flexible circuit board |
US5156144A (en) | 1989-10-20 | 1992-10-20 | Olympus Optical Co., Ltd. | Ultrasonic wave therapeutic device |
JPH03136642A (en) | 1989-10-20 | 1991-06-11 | Olympus Optical Co Ltd | Ultrasonic treatment device |
EP0424685B1 (en) | 1989-10-27 | 1995-05-10 | Storz Instrument Company | Method for driving an ultrasonic transducer |
ES2085885T3 (en) | 1989-11-08 | 1996-06-16 | George S Allen | MECHANICAL ARM FOR INTERACTIVE SURGERY SYSTEM DIRECTED BY IMAGES. |
US5070879A (en) | 1989-11-30 | 1991-12-10 | Acoustic Imaging Technologies Corp. | Ultrasound imaging method and apparatus |
CA2032204C (en) | 1989-12-14 | 1995-03-14 | Takashi Mochizuki | Three-dimensional ultrasonic scanner |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5209720A (en) | 1989-12-22 | 1993-05-11 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes |
US5149319A (en) | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
US5305757A (en) | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5012797A (en) | 1990-01-08 | 1991-05-07 | Montefiore Hospital Association Of Western Pennsylvania | Method for removing skin wrinkles |
JP3015481B2 (en) | 1990-03-28 | 2000-03-06 | 株式会社東芝 | Ultrasonic probe system |
IN172208B (en) | 1990-04-02 | 1993-05-01 | Sint Sa | |
JPH03297475A (en) | 1990-04-16 | 1991-12-27 | Ken Ishihara | Controlling method for emission of medicine by means of resonance sound wave |
US5205287A (en) | 1990-04-26 | 1993-04-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
DE4117638A1 (en) | 1990-05-30 | 1991-12-05 | Toshiba Kawasaki Kk | SHOCK WAVE GENERATOR WITH A PIEZOELECTRIC ELEMENT |
US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
US5191880A (en) | 1990-07-31 | 1993-03-09 | Mcleod Kenneth J | Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical loading of the bone tissue |
US5174929A (en) | 1990-08-31 | 1992-12-29 | Ciba-Geigy Corporation | Preparation of stable polyvinyl alcohol hydrogel contact lens |
DE4029175C2 (en) | 1990-09-13 | 1993-10-28 | Lauerer Friedrich | Electrical protection device |
SE501045C2 (en) | 1990-09-17 | 1994-10-24 | Roofer Int Ab | Method of laying roofing board and device for carrying out the procedure |
US5117832A (en) | 1990-09-21 | 1992-06-02 | Diasonics, Inc. | Curved rectangular/elliptical transducer |
JPH04150847A (en) | 1990-10-12 | 1992-05-25 | Katsuya Takasu | Armpit smell surgical apparatus and chip for operation |
US5685820A (en) | 1990-11-06 | 1997-11-11 | Partomed Medizintechnik Gmbh | Instrument for the penetration of body tissue |
GB9025431D0 (en) | 1990-11-22 | 1991-01-09 | Advanced Tech Lab | Three dimensional ultrasonic imaging |
US5997497A (en) | 1991-01-11 | 1999-12-07 | Advanced Cardiovascular Systems | Ultrasound catheter having integrated drug delivery system and methods of using same |
US5957882A (en) | 1991-01-11 | 1999-09-28 | Advanced Cardiovascular Systems, Inc. | Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels |
US5255681A (en) | 1991-03-20 | 1993-10-26 | Olympus Optical Co., Ltd. | Ultrasonic wave diagnosing apparatus having an ultrasonic wave transmitting and receiving part transmitting and receiving ultrasonic waves |
US5150714A (en) | 1991-05-10 | 1992-09-29 | Sri International | Ultrasonic inspection method and apparatus with audible output |
US5429582A (en) | 1991-06-14 | 1995-07-04 | Williams; Jeffery A. | Tumor treatment |
US5383917A (en) | 1991-07-05 | 1995-01-24 | Jawahar M. Desai | Device and method for multi-phase radio-frequency ablation |
US5327895A (en) | 1991-07-10 | 1994-07-12 | Kabushiki Kaisha Toshiba | Ultrasonic probe and ultrasonic diagnosing system using ultrasonic probe |
JP3095835B2 (en) | 1991-10-30 | 2000-10-10 | 株式会社町田製作所 | Gravity direction indicator for endoscopes |
US5704361A (en) | 1991-11-08 | 1998-01-06 | Mayo Foundation For Medical Education And Research | Volumetric image ultrasound transducer underfluid catheter system |
US5524620A (en) | 1991-11-12 | 1996-06-11 | November Technologies Ltd. | Ablation of blood thrombi by means of acoustic energy |
ATE144124T1 (en) | 1991-12-20 | 1996-11-15 | Technomed Medical Systems | DEVICE FOR ULTRASONIC THERAPY EMITTING SOUND WAVES, THERMAL EFFECTS AND CAVITATION EFFECTS |
US5230334A (en) | 1992-01-22 | 1993-07-27 | Summit Technology, Inc. | Method and apparatus for generating localized hyperthermia |
AU3727993A (en) | 1992-02-21 | 1993-09-13 | Diasonics Inc. | Ultrasound intracavity system for imaging therapy planning and treatment of focal disease |
US5269297A (en) | 1992-02-27 | 1993-12-14 | Angiosonics Inc. | Ultrasonic transmission apparatus |
JP3386488B2 (en) | 1992-03-10 | 2003-03-17 | 株式会社東芝 | Ultrasound therapy equipment |
WO1993019705A1 (en) | 1992-03-31 | 1993-10-14 | Massachusetts Institute Of Technology | Apparatus and method for acoustic heat generation and hyperthermia |
US5690608A (en) | 1992-04-08 | 1997-11-25 | Asec Co., Ltd. | Ultrasonic apparatus for health and beauty |
US5257970A (en) | 1992-04-09 | 1993-11-02 | Health Research, Inc. | In situ photodynamic therapy |
US5295484A (en) | 1992-05-19 | 1994-03-22 | Arizona Board Of Regents For And On Behalf Of The University Of Arizona | Apparatus and method for intra-cardiac ablation of arrhythmias |
JPH0773576B2 (en) | 1992-05-27 | 1995-08-09 | アロカ株式会社 | Ultrasonic probe for 3D data acquisition |
JP3257640B2 (en) | 1992-06-09 | 2002-02-18 | オリンパス光学工業株式会社 | Stereoscopic endoscope device |
US5321520A (en) | 1992-07-20 | 1994-06-14 | Automated Medical Access Corporation | Automated high definition/resolution image storage, retrieval and transmission system |
DE4229817C2 (en) | 1992-09-07 | 1996-09-12 | Siemens Ag | Method for the non-destructive and / or non-invasive measurement of a temperature change in the interior of a living object in particular |
WO1994006380A1 (en) | 1992-09-16 | 1994-03-31 | Hitachi, Ltd. | Ultrasonic irradiation apparatus and processor using the same |
US5687737A (en) | 1992-10-09 | 1997-11-18 | Washington University | Computerized three-dimensional cardiac mapping with interactive visual displays |
JP3224286B2 (en) | 1992-11-02 | 2001-10-29 | 株式会社日本自動車部品総合研究所 | Temperature measurement device using ultrasonic waves |
US5391197A (en) | 1992-11-13 | 1995-02-21 | Dornier Medical Systems, Inc. | Ultrasound thermotherapy probe |
US6537306B1 (en) * | 1992-11-13 | 2003-03-25 | The Regents Of The University Of California | Method of manufacture of a transurethral ultrasound applicator for prostate gland thermal therapy |
US5620479A (en) | 1992-11-13 | 1997-04-15 | The Regents Of The University Of California | Method and apparatus for thermal therapy of tumors |
DE4241161C2 (en) | 1992-12-07 | 1995-04-13 | Siemens Ag | Acoustic therapy facility |
JP3272792B2 (en) | 1992-12-15 | 2002-04-08 | フクダ電子株式会社 | Ultrasonic coupler manufacturing method |
US5573497A (en) | 1994-11-30 | 1996-11-12 | Technomed Medical Systems And Institut National | High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes |
DE4302538C1 (en) | 1993-01-29 | 1994-04-07 | Siemens Ag | Ultrasonic therapy device for tumour treatment lithotripsy or osteorestoration - with ultrasonic imaging and ultrasonic treatment modes using respective acoustic wave frequencies |
DE4302537C1 (en) | 1993-01-29 | 1994-04-28 | Siemens Ag | Ultrasound imaging and therapy device - generates imaging waves and focussed treatment waves having two differing frequencies for location and treatment of e.g tumours |
US5423220A (en) | 1993-01-29 | 1995-06-13 | Parallel Design | Ultrasonic transducer array and manufacturing method thereof |
US5453575A (en) | 1993-02-01 | 1995-09-26 | Endosonics Corporation | Apparatus and method for detecting blood flow in intravascular ultrasonic imaging |
US5267985A (en) | 1993-02-11 | 1993-12-07 | Trancell, Inc. | Drug delivery by multiple frequency phonophoresis |
DE69431741T2 (en) | 1993-03-12 | 2003-09-11 | Toshiba Kawasaki Kk | Device for medical treatment with ultrasound |
US5307812A (en) | 1993-03-26 | 1994-05-03 | General Electric Company | Heat surgery system monitored by real-time magnetic resonance profiling |
US5305756A (en) | 1993-04-05 | 1994-04-26 | Advanced Technology Laboratories, Inc. | Volumetric ultrasonic imaging with diverging elevational ultrasound beams |
EP0693954B1 (en) | 1993-04-15 | 1999-07-07 | Siemens Aktiengesellschaft | Therapeutic appliance for the treatment of conditions of the heart and of blood vessels in the vicinity of the heart |
AU6818694A (en) | 1993-04-26 | 1994-11-21 | St. Louis University | Indicating the position of a surgical probe |
DE4318237A1 (en) | 1993-06-01 | 1994-12-08 | Storz Medical Ag | Device for the treatment of biological tissue and body concretions |
US5460595A (en) | 1993-06-01 | 1995-10-24 | Dynatronics Laser Corporation | Multi-frequency ultrasound therapy systems and methods |
US5392259A (en) | 1993-06-15 | 1995-02-21 | Bolorforosh; Mir S. S. | Micro-grooves for the design of wideband clinical ultrasonic transducers |
US5398689A (en) | 1993-06-16 | 1995-03-21 | Hewlett-Packard Company | Ultrasonic probe assembly and cable therefor |
US5526812A (en) | 1993-06-21 | 1996-06-18 | General Electric Company | Display system for enhancing visualization of body structures during medical procedures |
ATE172370T1 (en) | 1993-07-26 | 1998-11-15 | Technomed Medical Systems | ENDOSCOPIC IMAGING AND THERAPY PROBE AND ITS TREATMENT SYSTEM |
JP2998505B2 (en) | 1993-07-29 | 2000-01-11 | 富士写真光機株式会社 | Radial ultrasonic scanner |
US5503320A (en) | 1993-08-19 | 1996-04-02 | United States Surgical Corporation | Surgical apparatus with indicator |
US5438998A (en) | 1993-09-07 | 1995-08-08 | Acuson Corporation | Broadband phased array transducer design with frequency controlled two dimension capability and methods for manufacture thereof |
US5792058A (en) | 1993-09-07 | 1998-08-11 | Acuson Corporation | Broadband phased array transducer with wide bandwidth, high sensitivity and reduced cross-talk and method for manufacture thereof |
US5379773A (en) | 1993-09-17 | 1995-01-10 | Hornsby; James J. | Echographic suction cannula and electronics therefor |
US5661235A (en) | 1993-10-01 | 1997-08-26 | Hysitron Incorporated | Multi-dimensional capacitive transducer |
US20050288748A1 (en) | 1993-10-04 | 2005-12-29 | Huan-Chen Li | Medical device for treating skin problems |
IL107523A (en) | 1993-11-07 | 2000-01-31 | Ultraguide Ltd | Articulated needle guide for ultrasound imaging and method of using same |
US5526814A (en) | 1993-11-09 | 1996-06-18 | General Electric Company | Automatically positioned focussed energy system guided by medical imaging |
US5380280A (en) | 1993-11-12 | 1995-01-10 | Peterson; Erik W. | Aspiration system having pressure-controlled and flow-controlled modes |
US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
US20020169394A1 (en) | 1993-11-15 | 2002-11-14 | Eppstein Jonathan A. | Integrated tissue poration, fluid harvesting and analysis device, and method therefor |
US5609562A (en) | 1993-11-16 | 1997-03-11 | Worldwide Optical Trocar Licensing Corporation | Visually directed trocar and method |
JPH07136162A (en) | 1993-11-17 | 1995-05-30 | Fujitsu Ltd | Ultrasonic coupler |
US5371483A (en) | 1993-12-20 | 1994-12-06 | Bhardwaj; Mahesh C. | High intensity guided ultrasound source |
US5471988A (en) | 1993-12-24 | 1995-12-05 | Olympus Optical Co., Ltd. | Ultrasonic diagnosis and therapy system in which focusing point of therapeutic ultrasonic wave is locked at predetermined position within observation ultrasonic scanning range |
JPH07184907A (en) | 1993-12-28 | 1995-07-25 | Toshiba Corp | Ultrasonic treating device |
DE4443947B4 (en) | 1994-01-14 | 2005-09-22 | Siemens Ag | endoscope |
US5507790A (en) | 1994-03-21 | 1996-04-16 | Weiss; William V. | Method of non-invasive reduction of human site-specific subcutaneous fat tissue deposits by accelerated lipolysis metabolism |
US5492126A (en) | 1994-05-02 | 1996-02-20 | Focal Surgery | Probe for medical imaging and therapy using ultrasound |
AU2373695A (en) | 1994-05-03 | 1995-11-29 | Board Of Regents, The University Of Texas System | Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy |
US5524624A (en) | 1994-05-05 | 1996-06-11 | Amei Technologies Inc. | Apparatus and method for stimulating tissue growth with ultrasound |
US5458596A (en) | 1994-05-06 | 1995-10-17 | Dorsal Orthopedic Corporation | Method and apparatus for controlled contraction of soft tissue |
US5549638A (en) | 1994-05-17 | 1996-08-27 | Burdette; Everette C. | Ultrasound device for use in a thermotherapy apparatus |
US5396143A (en) | 1994-05-20 | 1995-03-07 | Hewlett-Packard Company | Elevation aperture control of an ultrasonic transducer |
US5496256A (en) | 1994-06-09 | 1996-03-05 | Sonex International Corporation | Ultrasonic bone healing device for dental application |
US5575807A (en) | 1994-06-10 | 1996-11-19 | Zmd Corporation | Medical device power supply with AC disconnect alarm and method of supplying power to a medical device |
US5560362A (en) | 1994-06-13 | 1996-10-01 | Acuson Corporation | Active thermal control of ultrasound transducers |
US5540235A (en) | 1994-06-30 | 1996-07-30 | Wilson; John R. | Adaptor for neurophysiological monitoring with a personal computer |
FR2722358B1 (en) | 1994-07-08 | 1996-08-14 | Thomson Csf | BROADBAND MULTI-FREQUENCY ACOUSTIC TRANSDUCER |
NO300407B1 (en) | 1994-08-30 | 1997-05-26 | Vingmed Sound As | Apparatus for endoscope or gastroscope examination of patients |
US5829444A (en) | 1994-09-15 | 1998-11-03 | Visualization Technology, Inc. | Position tracking and imaging system for use in medical applications |
US5694936A (en) | 1994-09-17 | 1997-12-09 | Kabushiki Kaisha Toshiba | Ultrasonic apparatus for thermotherapy with variable frequency for suppressing cavitation |
US5810009A (en) | 1994-09-27 | 1998-09-22 | Kabushiki Kaisha Toshiba | Ultrasonic probe, ultrasonic probe device having the ultrasonic probe, and method of manufacturing the ultrasonic probe |
US5503152A (en) | 1994-09-28 | 1996-04-02 | Tetrad Corporation | Ultrasonic transducer assembly and method for three-dimensional imaging |
US5487388A (en) | 1994-11-01 | 1996-01-30 | Interspec. Inc. | Three dimensional ultrasonic scanning devices and techniques |
US5520188A (en) | 1994-11-02 | 1996-05-28 | Focus Surgery Inc. | Annular array transducer |
US5577507A (en) | 1994-11-21 | 1996-11-26 | General Electric Company | Compound lens for ultrasound transducer probe |
DE4446429C1 (en) | 1994-12-23 | 1996-08-22 | Siemens Ag | Device for treating an object with focused ultrasound waves |
US5999843A (en) | 1995-01-03 | 1999-12-07 | Omnicorder Technologies, Inc. | Detection of cancerous lesions by their effect on the spatial homogeneity of skin temperature |
US5626554A (en) | 1995-02-21 | 1997-05-06 | Exogen, Inc. | Gel containment structure |
US6019724A (en) | 1995-02-22 | 2000-02-01 | Gronningsaeter; Aage | Method for ultrasound guidance during clinical procedures |
DE59600577D1 (en) | 1995-03-10 | 1998-10-22 | Karlsruhe Forschzent | DEVICE FOR GUIDING SURGICAL INSTRUMENTS FOR ENDOSCOPIC SURGERY |
US6246898B1 (en) | 1995-03-28 | 2001-06-12 | Sonometrics Corporation | Method for carrying out a medical procedure using a three-dimensional tracking and imaging system |
US5658328A (en) | 1995-03-30 | 1997-08-19 | Johnson; Gerald W. | Endoscopic assisted mastopexy |
US5655535A (en) | 1996-03-29 | 1997-08-12 | Siemens Medical Systems, Inc. | 3-Dimensional compound ultrasound field of view |
US5873902A (en) | 1995-03-31 | 1999-02-23 | Focus Surgery, Inc. | Ultrasound intensity determining method and apparatus |
US5899861A (en) | 1995-03-31 | 1999-05-04 | Siemens Medical Systems, Inc. | 3-dimensional volume by aggregating ultrasound fields of view |
DE69634714T2 (en) | 1995-03-31 | 2006-01-19 | Kabushiki Kaisha Toshiba, Kawasaki | Therapeutic ultrasound device |
US5924989A (en) | 1995-04-03 | 1999-07-20 | Polz; Hans | Method and device for capturing diagnostically acceptable three-dimensional ultrasound image data records |
US5644085A (en) | 1995-04-03 | 1997-07-01 | General Electric Company | High density integrated ultrasonic phased array transducer and a method for making |
US5577502A (en) | 1995-04-03 | 1996-11-26 | General Electric Company | Imaging of interventional devices during medical procedures |
US5701900A (en) | 1995-05-01 | 1997-12-30 | Cedars-Sinai Medical Center | Ultrasonic transducer orientation sensing and display apparatus and method |
US5735280A (en) | 1995-05-02 | 1998-04-07 | Heart Rhythm Technologies, Inc. | Ultrasound energy delivery system and method |
US5755753A (en) | 1995-05-05 | 1998-05-26 | Thermage, Inc. | Method for controlled contraction of collagen tissue |
US5660836A (en) | 1995-05-05 | 1997-08-26 | Knowlton; Edward W. | Method and apparatus for controlled contraction of collagen tissue |
US6241753B1 (en) | 1995-05-05 | 2001-06-05 | Thermage, Inc. | Method for scar collagen formation and contraction |
US6430446B1 (en) | 1995-05-05 | 2002-08-06 | Thermage, Inc. | Apparatus for tissue remodeling |
US6425912B1 (en) | 1995-05-05 | 2002-07-30 | Thermage, Inc. | Method and apparatus for modifying skin surface and soft tissue structure |
US5558092A (en) | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
US5755228A (en) | 1995-06-07 | 1998-05-26 | Hologic, Inc. | Equipment and method for calibration and quality assurance of an ultrasonic bone anaylsis apparatus |
AU6276696A (en) | 1995-06-15 | 1997-01-15 | Regents Of The University Of Michigan, The | Method and apparatus for composition and display of three-dimensional image from two-dimensional ultrasound |
US5655538A (en) | 1995-06-19 | 1997-08-12 | General Electric Company | Ultrasonic phased array transducer with an ultralow impedance backfill and a method for making |
US6248073B1 (en) | 1995-06-29 | 2001-06-19 | Teratech Corporation | Ultrasound scan conversion with spatial dithering |
AU722539B2 (en) | 1995-07-16 | 2000-08-03 | Ultra-Guide Ltd. | Free-hand aiming of a needle guide |
US5706564A (en) | 1995-07-27 | 1998-01-13 | General Electric Company | Method for designing ultrasonic transducers using constraints on feasibility and transitional Butterworth-Thompson spectrum |
JPH0947458A (en) | 1995-08-09 | 1997-02-18 | Toshiba Corp | Ultrasonic therapeupic device and applicator |
US5638819A (en) | 1995-08-29 | 1997-06-17 | Manwaring; Kim H. | Method and apparatus for guiding an instrument to a target |
US5662116A (en) | 1995-09-12 | 1997-09-02 | Fuji Photo Optical Co., Ltd. | Multi-plane electronic scan ultrasound probe |
US5622175A (en) | 1995-09-29 | 1997-04-22 | Hewlett-Packard Company | Miniaturization of a rotatable sensor |
US5615091A (en) | 1995-10-11 | 1997-03-25 | Biochem International, Inc. | Isolation transformer for medical equipment |
US5618275A (en) | 1995-10-27 | 1997-04-08 | Sonex International Corporation | Ultrasonic method and apparatus for cosmetic and dermatological applications |
WO1997017018A1 (en) | 1995-11-09 | 1997-05-15 | Brigham & Women's Hospital | Aperiodic ultrasound phased array |
US7189230B2 (en) | 1996-01-05 | 2007-03-13 | Thermage, Inc. | Method for treating skin and underlying tissue |
US7006874B2 (en) | 1996-01-05 | 2006-02-28 | Thermage, Inc. | Treatment apparatus with electromagnetic energy delivery device and non-volatile memory |
US6350276B1 (en) | 1996-01-05 | 2002-02-26 | Thermage, Inc. | Tissue remodeling apparatus containing cooling fluid |
US20040000316A1 (en) | 1996-01-05 | 2004-01-01 | Knowlton Edward W. | Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient |
US7115123B2 (en) | 1996-01-05 | 2006-10-03 | Thermage, Inc. | Handpiece with electrode and non-volatile memory |
US7473251B2 (en) | 1996-01-05 | 2009-01-06 | Thermage, Inc. | Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient |
US20030212393A1 (en) | 1996-01-05 | 2003-11-13 | Knowlton Edward W. | Handpiece with RF electrode and non-volatile memory |
US5655539A (en) * | 1996-02-26 | 1997-08-12 | Abbott Laboratories | Method for conducting an ultrasound procedure using an ultrasound transmissive pad |
US5603323A (en) | 1996-02-27 | 1997-02-18 | Advanced Technology Laboratories, Inc. | Medical ultrasonic diagnostic system with upgradeable transducer probes and other features |
US5715823A (en) | 1996-02-27 | 1998-02-10 | Atlantis Diagnostics International, L.L.C. | Ultrasonic diagnostic imaging system with universal access to diagnostic information and images |
US6190323B1 (en) | 1996-03-13 | 2001-02-20 | Agielnt Technologies | Direct contact scanner and related method |
US5817013A (en) | 1996-03-19 | 1998-10-06 | Enable Medical Corporation | Method and apparatus for the minimally invasive harvesting of a saphenous vein and the like |
US5676692A (en) | 1996-03-28 | 1997-10-14 | Indianapolis Center For Advanced Research, Inc. | Focussed ultrasound tissue treatment method |
US5673699A (en) | 1996-05-31 | 1997-10-07 | Duke University | Method and apparatus for abberation correction in the presence of a distributed aberrator |
US5749364A (en) | 1996-06-21 | 1998-05-12 | Acuson Corporation | Method and apparatus for mapping pressure and tissue properties |
US5746762A (en) | 1996-06-24 | 1998-05-05 | Bass; Lawrence S. | Device and method for surgical flap dissection |
JP2002515786A (en) | 1996-06-28 | 2002-05-28 | ソントラ メディカル,エル.ピー. | Ultrasound enhancement of transdermal delivery |
US5671746A (en) | 1996-07-29 | 1997-09-30 | Acuson Corporation | Elevation steerable ultrasound transducer array |
US5763886A (en) | 1996-08-07 | 1998-06-09 | Northrop Grumman Corporation | Two-dimensional imaging backscatter probe |
US5971949A (en) | 1996-08-19 | 1999-10-26 | Angiosonics Inc. | Ultrasound transmission apparatus and method of using same |
US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
US6605041B2 (en) | 1996-08-22 | 2003-08-12 | Synthes (U.S.A.) | 3-D ultrasound recording device |
US20020002345A1 (en) | 1996-08-22 | 2002-01-03 | Marlinghaus Ernest H. | Device and therapeutic method for treatment of the heart or pancreas |
US5844140A (en) | 1996-08-27 | 1998-12-01 | Seale; Joseph B. | Ultrasound beam alignment servo |
DE19635593C1 (en) | 1996-09-02 | 1998-04-23 | Siemens Ag | Ultrasound transducer for diagnostic and therapeutic use |
US5795297A (en) | 1996-09-12 | 1998-08-18 | Atlantis Diagnostics International, L.L.C. | Ultrasonic diagnostic imaging system with personal computer architecture |
US5727554A (en) | 1996-09-19 | 1998-03-17 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Apparatus responsive to movement of a patient during treatment/diagnosis |
US6283919B1 (en) | 1996-11-26 | 2001-09-04 | Atl Ultrasound | Ultrasonic diagnostic imaging with blended tissue harmonic signals |
US5665053A (en) | 1996-09-27 | 1997-09-09 | Jacobs; Robert A. | Apparatus for performing endermology with ultrasound |
US5879303A (en) | 1996-09-27 | 1999-03-09 | Atl Ultrasound | Ultrasonic diagnostic imaging of response frequency differing from transmit frequency |
US5957941A (en) | 1996-09-27 | 1999-09-28 | Boston Scientific Corporation | Catheter system and drive assembly thereof |
US5932539A (en) * | 1996-10-15 | 1999-08-03 | The Board Of Trustees Of The University Of Illinois | Biodegradable polymer matrix for tissue repair |
US5746005A (en) | 1996-10-22 | 1998-05-05 | Powerhorse Corporation | Angular position sensor |
US6719755B2 (en) | 1996-10-22 | 2004-04-13 | Epicor Medical, Inc. | Methods and devices for ablation |
US5769790A (en) | 1996-10-25 | 1998-06-23 | General Electric Company | Focused ultrasound surgery system guided by ultrasound imaging |
DE69732511T2 (en) | 1996-10-29 | 2006-01-12 | Koninklijke Philips Electronics N.V. | Processing method for signals of objects with moving parts and echography apparatus therefor |
US6216704B1 (en) | 1997-08-13 | 2001-04-17 | Surx, Inc. | Noninvasive devices, methods, and systems for shrinking of tissues |
US5827204A (en) | 1996-11-26 | 1998-10-27 | Grandia; Willem | Medical noninvasive operations using focused modulated high power ultrasound |
US5810008A (en) | 1996-12-03 | 1998-09-22 | Isg Technologies Inc. | Apparatus and method for visualizing ultrasonic images |
FR2756741B1 (en) | 1996-12-05 | 1999-01-08 | Cird Galderma | USE OF A CHROMOPHORE IN A COMPOSITION INTENDED TO BE APPLIED TO THE SKIN BEFORE LASER TREATMENT |
US5820564A (en) | 1996-12-16 | 1998-10-13 | Albatross Technologies, Inc. | Method and apparatus for surface ultrasound imaging |
IL120079A (en) | 1997-01-27 | 2001-03-19 | Technion Res & Dev Foundation | Ultrasound system and cosmetic methods utilizing same |
US7789841B2 (en) | 1997-02-06 | 2010-09-07 | Exogen, Inc. | Method and apparatus for connective tissue treatment |
US7108663B2 (en) | 1997-02-06 | 2006-09-19 | Exogen, Inc. | Method and apparatus for cartilage growth stimulation |
US5904659A (en) | 1997-02-14 | 1999-05-18 | Exogen, Inc. | Ultrasonic treatment for wounds |
US5853367A (en) | 1997-03-17 | 1998-12-29 | General Electric Company | Task-interface and communications system and method for ultrasound imager control |
US5938612A (en) * | 1997-05-05 | 1999-08-17 | Creare Inc. | Multilayer ultrasonic transducer array including very thin layer of transducer elements |
US5840032A (en) | 1997-05-07 | 1998-11-24 | General Electric Company | Method and apparatus for three-dimensional ultrasound imaging using transducer array having uniform elevation beamwidth |
WO1998051255A1 (en) | 1997-05-15 | 1998-11-19 | Matsushita Electric Works, Ltd. | Ultrasonic device |
US5931805A (en) | 1997-06-02 | 1999-08-03 | Pharmasonics, Inc. | Catheters comprising bending transducers and methods for their use |
JP3783339B2 (en) | 1997-06-13 | 2006-06-07 | 松下電工株式会社 | Ultrasonic beauty device |
US5968034A (en) | 1997-06-24 | 1999-10-19 | Laser Aesthetics, Inc. | Pulsed filament lamp for dermatological treatment |
US5810888A (en) | 1997-06-26 | 1998-09-22 | Massachusetts Institute Of Technology | Thermodynamic adaptive phased array system for activating thermosensitive liposomes in targeted drug delivery |
US6093883A (en) | 1997-07-15 | 2000-07-25 | Focus Surgery, Inc. | Ultrasound intensity determining method and apparatus |
US5876431A (en) | 1997-07-30 | 1999-03-02 | Sulzer Intermedics Inc. | Small cable endocardial lead with exposed guide tube |
TW370458B (en) | 1997-08-11 | 1999-09-21 | Matsushita Electric Works Ltd | Ultrasonic facial apparatus |
US20020169442A1 (en) | 1997-08-12 | 2002-11-14 | Joseph Neev | Device and a method for treating skin conditions |
US6413253B1 (en) | 1997-08-16 | 2002-07-02 | Cooltouch Corporation | Subsurface heating of material |
US6126619A (en) | 1997-09-02 | 2000-10-03 | Transon Llc | Multiple transducer assembly and method for coupling ultrasound energy to a body |
US5990598A (en) | 1997-09-23 | 1999-11-23 | Hewlett-Packard Company | Segment connections for multiple elevation transducers |
US6113558A (en) | 1997-09-29 | 2000-09-05 | Angiosonics Inc. | Pulsed mode lysis method |
US5923099A (en) | 1997-09-30 | 1999-07-13 | Lam Research Corporation | Intelligent backup power controller |
US6049159A (en) | 1997-10-06 | 2000-04-11 | Albatros Technologies, Inc. | Wideband acoustic transducer |
US6500121B1 (en) | 1997-10-14 | 2002-12-31 | Guided Therapy Systems, Inc. | Imaging, therapy, and temperature monitoring ultrasonic system |
US6050943A (en) | 1997-10-14 | 2000-04-18 | Guided Therapy Systems, Inc. | Imaging, therapy, and temperature monitoring ultrasonic system |
US6623430B1 (en) | 1997-10-14 | 2003-09-23 | Guided Therapy Systems, Inc. | Method and apparatus for safety delivering medicants to a region of tissue using imaging, therapy and temperature monitoring ultrasonic system |
US6325758B1 (en) | 1997-10-27 | 2001-12-04 | Nomos Corporation | Method and apparatus for target position verification |
US6071239A (en) | 1997-10-27 | 2000-06-06 | Cribbs; Robert W. | Method and apparatus for lipolytic therapy using ultrasound energy |
US6007499A (en) | 1997-10-31 | 1999-12-28 | University Of Washington | Method and apparatus for medical procedures using high-intensity focused ultrasound |
US20060184071A1 (en) | 1997-12-29 | 2006-08-17 | Julia Therapeutics, Llc | Treatment of skin with acoustic energy |
US6113559A (en) | 1997-12-29 | 2000-09-05 | Klopotek; Peter J. | Method and apparatus for therapeutic treatment of skin with ultrasound |
US6325769B1 (en) | 1998-12-29 | 2001-12-04 | Collapeutics, Llc | Method and apparatus for therapeutic treatment of skin |
US20020040199A1 (en) | 1997-12-29 | 2002-04-04 | Klopotek Peter J. | Method and apparatus for therapeutic treatment of skin |
US20080027328A1 (en) | 1997-12-29 | 2008-01-31 | Julia Therapeutics, Llc | Multi-focal treatment of skin with acoustic energy |
US6575956B1 (en) * | 1997-12-31 | 2003-06-10 | Pharmasonics, Inc. | Methods and apparatus for uniform transcutaneous therapeutic ultrasound |
US6171244B1 (en) | 1997-12-31 | 2001-01-09 | Acuson Corporation | Ultrasonic system and method for storing data |
JPH11244386A (en) | 1998-01-01 | 1999-09-14 | Ge Yokogawa Medical Systems Ltd | Method for stopping blood circulation and heater |
DE19800416C2 (en) | 1998-01-08 | 2002-09-19 | Storz Karl Gmbh & Co Kg | Device for the treatment of body tissue, in particular soft tissue close to the surface, by means of ultrasound |
CN1058905C (en) | 1998-01-25 | 2000-11-29 | 重庆海扶(Hifu)技术有限公司 | High-intensity focus supersonic tumor scanning therapy system |
US20020055702A1 (en) | 1998-02-10 | 2002-05-09 | Anthony Atala | Ultrasound-mediated drug delivery |
DE69836907T2 (en) | 1998-02-10 | 2007-11-08 | Biosense Webster, Inc., Diamond Bar | Probe arrangement for improved catheter calibration |
US6101407A (en) | 1998-02-13 | 2000-08-08 | Eastman Kodak Company | Method and system for remotely viewing and configuring output from a medical imaging device |
US6325798B1 (en) | 1998-02-19 | 2001-12-04 | Curon Medical, Inc. | Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions |
US6039689A (en) | 1998-03-11 | 2000-03-21 | Riverside Research Institute | Stripe electrode transducer for use with therapeutic ultrasonic radiation treatment |
US6013032A (en) * | 1998-03-13 | 2000-01-11 | Hewlett-Packard Company | Beamforming methods and apparatus for three-dimensional ultrasound imaging using two-dimensional transducer array |
US6685640B1 (en) | 1998-03-30 | 2004-02-03 | Focus Surgery, Inc. | Ablation system |
WO1999049788A1 (en) | 1998-03-30 | 1999-10-07 | Focus Surgery, Inc. | Ablation system |
US6432057B1 (en) | 1998-03-31 | 2002-08-13 | Lunar Corporation | Stabilizing acoustic coupler for limb densitometry |
US6039048A (en) | 1998-04-08 | 2000-03-21 | Silberg; Barry | External ultrasound treatment of connective tissue |
US6022327A (en) | 1998-05-04 | 2000-02-08 | Chang; Henry Ping | Facial steamer machine with detachable function units |
US6004262A (en) | 1998-05-04 | 1999-12-21 | Ad-Tech Medical Instrument Corp. | Visually-positioned electrical monitoring apparatus |
US5977538A (en) | 1998-05-11 | 1999-11-02 | Imarx Pharmaceutical Corp. | Optoacoustic imaging system |
US6186951B1 (en) | 1998-05-26 | 2001-02-13 | Riverside Research Institute | Ultrasonic systems and methods for fluid perfusion and flow rate measurement |
US6440121B1 (en) | 1998-05-28 | 2002-08-27 | Pearl Technology Holdings, Llc. | Surgical device for performing face-lifting surgery using radiofrequency energy |
US7494488B2 (en) | 1998-05-28 | 2009-02-24 | Pearl Technology Holdings, Llc | Facial tissue strengthening and tightening device and methods |
US6432101B1 (en) | 1998-05-28 | 2002-08-13 | Pearl Technology Holdings, Llc | Surgical device for performing face-lifting using electromagnetic radiation |
US6077294A (en) | 1998-06-11 | 2000-06-20 | Cynosure, Inc. | Method for non-invasive wrinkle removal and skin treatment |
US6425865B1 (en) | 1998-06-12 | 2002-07-30 | The University Of British Columbia | Robotically assisted medical ultrasound |
US6086533A (en) | 1998-06-12 | 2000-07-11 | Children's Medical Center Corporation | Non-invasive in vivo pressure measurement |
US6322532B1 (en) | 1998-06-24 | 2001-11-27 | 3M Innovative Properties Company | Sonophoresis method and apparatus |
US6036646A (en) | 1998-07-10 | 2000-03-14 | Guided Therapy Systems, Inc. | Method and apparatus for three dimensional ultrasound imaging |
US6889089B2 (en) | 1998-07-28 | 2005-05-03 | Scimed Life Systems, Inc. | Apparatus and method for treating tumors near the surface of an organ |
AU754022B2 (en) | 1998-07-29 | 2002-10-31 | Pharmasonics, Inc. | Ultrasonic enhancement of drug injection |
US20030009153A1 (en) | 1998-07-29 | 2003-01-09 | Pharmasonics, Inc. | Ultrasonic enhancement of drug injection |
US6443914B1 (en) | 1998-08-10 | 2002-09-03 | Lysonix, Inc. | Apparatus and method for preventing and treating cellulite |
US6042556A (en) | 1998-09-04 | 2000-03-28 | University Of Washington | Method for determining phase advancement of transducer elements in high intensity focused ultrasound |
CN101044990B (en) | 1998-09-11 | 2011-11-23 | Gr智力储备股份有限公司 | Methods for using resonant acoustic and/or resonant acousto-em energy to detect and/or effect structures |
IL126236A0 (en) | 1998-09-16 | 1999-05-09 | Ultra Cure Ltd | A method device and system for skin peeling |
US6425867B1 (en) | 1998-09-18 | 2002-07-30 | University Of Washington | Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy |
US7686763B2 (en) | 1998-09-18 | 2010-03-30 | University Of Washington | Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy |
JP4460691B2 (en) | 1998-09-30 | 2010-05-12 | 株式会社東芝 | Ultrasonic therapy device |
JP3330092B2 (en) | 1998-09-30 | 2002-09-30 | 松下電器産業株式会社 | Ultrasound diagnostic equipment |
US6302848B1 (en) | 1999-07-01 | 2001-10-16 | Sonotech, Inc. | In vivo biocompatible acoustic coupling media |
IL126505A0 (en) | 1998-10-09 | 1999-08-17 | Ultra Cure Ltd | A method and device for hair removal |
US6540700B1 (en) | 1998-10-26 | 2003-04-01 | Kabushiki Kaisha Toshiba | Ultrasound treatment apparatus |
JP4095729B2 (en) | 1998-10-26 | 2008-06-04 | 株式会社日立製作所 | Therapeutic ultrasound system |
US6948843B2 (en) | 1998-10-28 | 2005-09-27 | Covaris, Inc. | Method and apparatus for acoustically controlling liquid solutions in microfluidic devices |
AU1600000A (en) | 1998-10-28 | 2000-05-15 | Covaris, Inc. | Apparatus and methods for controlling sonic treatment |
US6080108A (en) | 1998-11-17 | 2000-06-27 | Atl Ultrasound, Inc. | Scanning aid for quantified three dimensional ultrasonic diagnostic imaging |
US6159150A (en) | 1998-11-20 | 2000-12-12 | Acuson Corporation | Medical diagnostic ultrasonic imaging system with auxiliary processor |
AU1128600A (en) | 1998-11-20 | 2000-06-13 | Joie P. Jones | Methods for selectively dissolving and removing materials using ultra-high frequency ultrasound |
US6142946A (en) | 1998-11-20 | 2000-11-07 | Atl Ultrasound, Inc. | Ultrasonic diagnostic imaging system with cordless scanheads |
US6676655B2 (en) | 1998-11-30 | 2004-01-13 | Light Bioscience L.L.C. | Low intensity light therapy for the manipulation of fibroblast, and fibroblast-derived mammalian cells and collagen |
US6936044B2 (en) | 1998-11-30 | 2005-08-30 | Light Bioscience, Llc | Method and apparatus for the stimulation of hair growth |
US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
JP4089058B2 (en) | 1998-12-10 | 2008-05-21 | ソニー株式会社 | Cleaning device and cleaning method for printing screen |
US6309355B1 (en) | 1998-12-22 | 2001-10-30 | The Regents Of The University Of Michigan | Method and assembly for performing ultrasound surgery using cavitation |
US6296619B1 (en) | 1998-12-30 | 2001-10-02 | Pharmasonics, Inc. | Therapeutic ultrasonic catheter for delivering a uniform energy dose |
US6428532B1 (en) | 1998-12-30 | 2002-08-06 | The General Hospital Corporation | Selective tissue targeting by difference frequency of two wavelengths |
US6183773B1 (en) | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
JP2000214966A (en) | 1999-01-20 | 2000-08-04 | Ricoh Co Ltd | Portable information processor |
US6200308B1 (en) | 1999-01-29 | 2001-03-13 | Candela Corporation | Dynamic cooling of tissue for radiation treatment |
US6139499A (en) | 1999-02-22 | 2000-10-31 | Wilk; Peter J. | Ultrasonic medical system and associated method |
US6508774B1 (en) | 1999-03-09 | 2003-01-21 | Transurgical, Inc. | Hifu applications with feedback control |
ATE298536T1 (en) | 1999-03-09 | 2005-07-15 | Thermage Inc | DEVICE FOR TREATING TISSUE |
US6775404B1 (en) | 1999-03-18 | 2004-08-10 | University Of Washington | Apparatus and method for interactive 3D registration of ultrasound and magnetic resonance images based on a magnetic position sensor |
US6375672B1 (en) | 1999-03-22 | 2002-04-23 | Board Of Trustees Of Michigan State University | Method for controlling the chemical and heat induced responses of collagenous materials |
US6488626B1 (en) | 1999-04-07 | 2002-12-03 | Riverside Research Institute | Ultrasonic sensing by induced tissue motion |
US6408212B1 (en) | 1999-04-13 | 2002-06-18 | Joseph Neev | Method for treating acne |
US6210327B1 (en) | 1999-04-28 | 2001-04-03 | General Electric Company | Method and apparatus for sending ultrasound image data to remotely located device |
US6268405B1 (en) | 1999-05-04 | 2001-07-31 | Porex Surgical, Inc. | Hydrogels and methods of making and using same |
US6251088B1 (en) | 1999-05-12 | 2001-06-26 | Jonathan J. Kaufman | Ultrasonic plantar fasciitis therapy: apparatus and method |
US20030060736A1 (en) | 1999-05-14 | 2003-03-27 | Martin Roy W. | Lens-focused ultrasonic applicator for medical applications |
US6217530B1 (en) | 1999-05-14 | 2001-04-17 | University Of Washington | Ultrasonic applicator for medical applications |
US6666835B2 (en) | 1999-05-14 | 2003-12-23 | University Of Washington | Self-cooled ultrasonic applicator for medical applications |
US6233476B1 (en) | 1999-05-18 | 2001-05-15 | Mediguide Ltd. | Medical positioning system |
US7399279B2 (en) | 1999-05-28 | 2008-07-15 | Physiosonics, Inc | Transmitter patterns for multi beam reception |
US6193658B1 (en) | 1999-06-24 | 2001-02-27 | Martin E Wendelken | Method and kit for wound evaluation |
US6287257B1 (en) | 1999-06-29 | 2001-09-11 | Acuson Corporation | Method and system for configuring a medical diagnostic ultrasound imaging system |
AU2002359840A1 (en) | 1999-06-30 | 2003-07-09 | Thermage, Inc. | Liquid cooled RF handpiece |
GB9915707D0 (en) | 1999-07-05 | 1999-09-08 | Young Michael J R | Method and apparatus for focused treatment of subcutaneous blood vessels |
US20030216795A1 (en) * | 1999-07-07 | 2003-11-20 | Yoram Harth | Apparatus and method for high energy photodynamic therapy of acne vulgaris, seborrhea and other skin disorders |
US6390982B1 (en) | 1999-07-23 | 2002-05-21 | Univ Florida | Ultrasonic guidance of target structures for medical procedures |
US6451007B1 (en) | 1999-07-29 | 2002-09-17 | Dale E. Koop | Thermal quenching of tissue |
US6533726B1 (en) | 1999-08-09 | 2003-03-18 | Riverside Research Institute | System and method for ultrasonic harmonic imaging for therapy guidance and monitoring |
US20020173721A1 (en) | 1999-08-20 | 2002-11-21 | Novasonics, Inc. | User interface for handheld imaging devices |
JP3848572B2 (en) | 1999-09-10 | 2006-11-22 | プロリズム,インコーポレイテッド | Device for occluding anatomic tissue |
US7510536B2 (en) * | 1999-09-17 | 2009-03-31 | University Of Washington | Ultrasound guided high intensity focused ultrasound treatment of nerves |
US6123081A (en) | 1999-09-22 | 2000-09-26 | Durette; Jean-Francois | Ocular surgical protective shield |
US6301989B1 (en) | 1999-09-30 | 2001-10-16 | Civco Medical Instruments, Inc. | Medical imaging instrument positioning device |
US20040158150A1 (en) | 1999-10-05 | 2004-08-12 | Omnisonics Medical Technologies, Inc. | Apparatus and method for an ultrasonic medical device for tissue remodeling |
US6440071B1 (en) | 1999-10-18 | 2002-08-27 | Guided Therapy Systems, Inc. | Peripheral ultrasound imaging system |
JP2003512103A (en) | 1999-10-18 | 2003-04-02 | フォーカス サージェリー,インコーポレイテッド | Split beam converter |
US20050240170A1 (en) | 1999-10-25 | 2005-10-27 | Therus Corporation | Insertable ultrasound probes, systems, and methods for thermal therapy |
US20030229331A1 (en) | 1999-11-05 | 2003-12-11 | Pharmasonics, Inc. | Methods and apparatus for uniform transcutaneous therapeutic ultrasound |
US6338716B1 (en) | 1999-11-24 | 2002-01-15 | Acuson Corporation | Medical diagnostic ultrasonic transducer probe and imaging system for use with a position and orientation sensor |
US6626855B1 (en) | 1999-11-26 | 2003-09-30 | Therus Corpoation | Controlled high efficiency lesion formation using high intensity ultrasound |
US6325540B1 (en) | 1999-11-29 | 2001-12-04 | General Electric Company | Method and apparatus for remotely configuring and servicing a field replaceable unit in a medical diagnostic system |
US6356780B1 (en) | 1999-12-22 | 2002-03-12 | General Electric Company | Method and apparatus for managing peripheral devices in a medical imaging system |
CA2394892A1 (en) | 1999-12-23 | 2001-06-28 | Therus Corporation | Ultrasound transducers for imaging and therapy |
US6436061B1 (en) | 1999-12-29 | 2002-08-20 | Peter D. Costantino | Ultrasound treatment of varicose veins |
US6699237B2 (en) | 1999-12-30 | 2004-03-02 | Pearl Technology Holdings, Llc | Tissue-lifting device |
US6409720B1 (en) | 2000-01-19 | 2002-06-25 | Medtronic Xomed, Inc. | Methods of tongue reduction using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
US6595934B1 (en) | 2000-01-19 | 2003-07-22 | Medtronic Xomed, Inc. | Methods of skin rejuvenation using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
US7706882B2 (en) | 2000-01-19 | 2010-04-27 | Medtronic, Inc. | Methods of using high intensity focused ultrasound to form an ablated tissue area |
US6692450B1 (en) | 2000-01-19 | 2004-02-17 | Medtronic Xomed, Inc. | Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same |
US6413254B1 (en) | 2000-01-19 | 2002-07-02 | Medtronic Xomed, Inc. | Method of tongue reduction by thermal ablation using high intensity focused ultrasound |
US6361531B1 (en) | 2000-01-21 | 2002-03-26 | Medtronic Xomed, Inc. | Focused ultrasound ablation devices having malleable handle shafts and methods of using the same |
US6517484B1 (en) | 2000-02-28 | 2003-02-11 | Wilk Patent Development Corporation | Ultrasonic imaging system and associated method |
US6511427B1 (en) | 2000-03-10 | 2003-01-28 | Acuson Corporation | System and method for assessing body-tissue properties using a medical ultrasound transducer probe with a body-tissue parameter measurement mechanism |
US6428477B1 (en) | 2000-03-10 | 2002-08-06 | Koninklijke Philips Electronics, N.V. | Delivery of theraputic ultrasound by two dimensional ultrasound array |
US6419648B1 (en) | 2000-04-21 | 2002-07-16 | Insightec-Txsonics Ltd. | Systems and methods for reducing secondary hot spots in a phased array focused ultrasound system |
AU2001257328A1 (en) | 2000-04-28 | 2001-11-12 | Focus Surgery, Inc. | Ablation system with visualization |
AU2001255724A1 (en) | 2000-04-29 | 2001-11-12 | Focus Surgery, Inc. | Non-invasive tissue characterization |
US6312385B1 (en) | 2000-05-01 | 2001-11-06 | Ge Medical Systems Global Technology Company, Llc | Method and apparatus for automatic detection and sizing of cystic objects |
WO2002003873A2 (en) | 2000-07-10 | 2002-01-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH | Radiofrequency probes for tissue treatment and methods of use |
AU2000264703A1 (en) | 2000-07-31 | 2002-02-13 | El. En. S.P.A. | Method and device for epilation by ultrasound |
JP3556582B2 (en) | 2000-08-02 | 2004-08-18 | 松下電器産業株式会社 | Ultrasound diagnostic equipment |
CA2422865C (en) | 2000-08-16 | 2012-10-16 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Aminolevulinic acid photodynamic therapy for treating sebaceous gland disorders |
US20020072691A1 (en) | 2000-08-24 | 2002-06-13 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasonic energy to the thoracic cavity |
US20040073115A1 (en) | 2000-08-24 | 2004-04-15 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasound energy to increase tissue perfusion and/or vasodilation without substantial deep heating of tissue |
US7335169B2 (en) | 2000-08-24 | 2008-02-26 | Timi 3 Systems, Inc. | Systems and methods for delivering ultrasound energy at an output power level that remains essentially constant despite variations in transducer impedance |
US6790187B2 (en) | 2000-08-24 | 2004-09-14 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasonic energy |
US20020082529A1 (en) | 2000-08-24 | 2002-06-27 | Timi 3 Systems, Inc. | Systems and methods for applying pulsed ultrasonic energy |
JP2002078764A (en) | 2000-09-06 | 2002-03-19 | Purotec Fuji:Kk | Portable cosmetic massage machine |
JP2004508867A (en) | 2000-09-19 | 2004-03-25 | フォーカス サージェリー,インコーポレイテッド | Tissue therapy and devices |
US6524250B1 (en) | 2000-09-19 | 2003-02-25 | Pearl Technology Holdings, Llc | Fat layer thickness mapping system to guide liposuction surgery |
US6910139B2 (en) | 2000-10-02 | 2005-06-21 | Fujitsu Limited | Software processing apparatus with a switching processing unit for displaying animation images in an environment operating base on type of power supply |
KR100400870B1 (en) * | 2000-10-10 | 2003-10-08 | 김영애 | remote dermal diagnosing and curing device |
US6882884B1 (en) | 2000-10-13 | 2005-04-19 | Soundskin, L.L.C. | Process for the stimulation of production of extracellular dermal proteins in human tissue |
JP2001170068A (en) | 2000-10-16 | 2001-06-26 | Toshiba Corp | Ultrasonic treatment instrument |
AU2002212639A1 (en) | 2000-10-18 | 2002-05-15 | Paieon Inc. | Method and system for positioning a device in a tubular organ |
US6540685B1 (en) | 2000-11-09 | 2003-04-01 | Koninklijke Philips Electronics N.V. | Ultrasound diagnostic device |
US6821274B2 (en) | 2001-03-07 | 2004-11-23 | Gendel Ltd. | Ultrasound therapy for selective cell ablation |
US6875176B2 (en) | 2000-11-28 | 2005-04-05 | Aller Physionix Limited | Systems and methods for making noninvasive physiological assessments |
US6618620B1 (en) | 2000-11-28 | 2003-09-09 | Txsonics Ltd. | Apparatus for controlling thermal dosing in an thermal treatment system |
GB0030449D0 (en) | 2000-12-13 | 2001-01-24 | Deltex Guernsey Ltd | Improvements in or relating to doppler haemodynamic monitors |
US6746444B2 (en) | 2000-12-18 | 2004-06-08 | Douglas J. Key | Method of amplifying a beneficial selective skin response to light energy |
US6626854B2 (en) | 2000-12-27 | 2003-09-30 | Insightec - Txsonics Ltd. | Systems and methods for ultrasound assisted lipolysis |
US6645162B2 (en) | 2000-12-27 | 2003-11-11 | Insightec - Txsonics Ltd. | Systems and methods for ultrasound assisted lipolysis |
JP2005502385A (en) | 2000-12-28 | 2005-01-27 | パロマー・メディカル・テクノロジーズ・インコーポレーテッド | Method and apparatus for performing skin therapy EMR treatment |
US7914453B2 (en) | 2000-12-28 | 2011-03-29 | Ardent Sound, Inc. | Visual imaging system for ultrasonic probe |
US6540679B2 (en) | 2000-12-28 | 2003-04-01 | Guided Therapy Systems, Inc. | Visual imaging system for ultrasonic probe |
US7347855B2 (en) | 2001-10-29 | 2008-03-25 | Ultrashape Ltd. | Non-invasive ultrasonic body contouring |
US6607498B2 (en) | 2001-01-03 | 2003-08-19 | Uitra Shape, Inc. | Method and apparatus for non-invasive body contouring by lysing adipose tissue |
US6569099B1 (en) | 2001-01-12 | 2003-05-27 | Eilaz Babaev | Ultrasonic method and device for wound treatment |
JP2002209905A (en) | 2001-01-22 | 2002-07-30 | Hitachi Medical Corp | Ultrasonic therapy probe and ultrasonic therapy apparatus |
US6626834B2 (en) | 2001-01-25 | 2003-09-30 | Shane Dunne | Spiral scanner with electronic control |
JP2002238919A (en) | 2001-02-20 | 2002-08-27 | Olympus Optical Co Ltd | Control apparatus for medical care system and medical care system |
JP2002248153A (en) | 2001-02-23 | 2002-09-03 | Matsushita Electric Works Ltd | Ultrasonic cosmetic device |
US6569108B2 (en) | 2001-03-28 | 2003-05-27 | Profile, Llc | Real time mechanical imaging of the prostate |
US6804327B2 (en) | 2001-04-03 | 2004-10-12 | Lambda Physik Ag | Method and apparatus for generating high output power gas discharge based source of extreme ultraviolet radiation and/or soft x-rays |
US20020165529A1 (en) | 2001-04-05 | 2002-11-07 | Danek Christopher James | Method and apparatus for non-invasive energy delivery |
US6478754B1 (en) | 2001-04-23 | 2002-11-12 | Advanced Medical Applications, Inc. | Ultrasonic method and device for wound treatment |
US6663627B2 (en) | 2001-04-26 | 2003-12-16 | Medtronic, Inc. | Ablation system and method of use |
WO2002087692A1 (en) | 2001-04-26 | 2002-11-07 | The Procter & Gamble Company | A method and apparatus for the treatment of cosmetic skin conditioins |
JP3937755B2 (en) | 2001-05-28 | 2007-06-27 | 松下電工株式会社 | Ultrasonic beauty device |
US7846096B2 (en) | 2001-05-29 | 2010-12-07 | Ethicon Endo-Surgery, Inc. | Method for monitoring of medical treatment using pulse-echo ultrasound |
US20030032898A1 (en) | 2001-05-29 | 2003-02-13 | Inder Raj. S. Makin | Method for aiming ultrasound for medical treatment |
US7058440B2 (en) | 2001-06-28 | 2006-06-06 | Koninklijke Philips Electronics N.V. | Dynamic computed tomography imaging using positional state modeling |
US7056331B2 (en) | 2001-06-29 | 2006-06-06 | Quill Medical, Inc. | Suture method |
US6659956B2 (en) | 2001-06-29 | 2003-12-09 | Barzell-Whitmore Maroon Bells, Inc. | Medical instrument positioner |
US6932771B2 (en) | 2001-07-09 | 2005-08-23 | Civco Medical Instruments Co., Inc. | Tissue warming device and method |
FR2827149B1 (en) | 2001-07-13 | 2003-10-10 | Technomed Medical Systems | FOCUSED ULTRASOUND TREATMENT PROBE |
JP2003050298A (en) | 2001-08-06 | 2003-02-21 | Fuji Photo Film Co Ltd | Radiographic image conversion panel and its manufacturing method |
US7018396B2 (en) | 2001-08-07 | 2006-03-28 | New England Medical Center Hospitals, Inc. | Method of treating acne |
US20030032900A1 (en) | 2001-08-08 | 2003-02-13 | Engii (2001) Ltd. | System and method for facial treatment |
DE10140064A1 (en) | 2001-08-16 | 2003-03-13 | Rainer Weismueller | Cosmetic or medical treatment of the skin using ultrasound waves, e.g. permanent hair removal using a simple device comprising a mechanical oscillator and focussing lenses with a spacer for varying the distance to the skin |
US7094252B2 (en) | 2001-08-21 | 2006-08-22 | Cooltouch Incorporated | Enhanced noninvasive collagen remodeling |
US6773409B2 (en) * | 2001-09-19 | 2004-08-10 | Surgrx Llc | Surgical system for applying ultrasonic energy to tissue |
US6638226B2 (en) | 2001-09-28 | 2003-10-28 | Teratech Corporation | Ultrasound imaging system |
US6974417B2 (en) | 2001-10-05 | 2005-12-13 | Queen's University At Kingston | Ultrasound transducer array |
US6920883B2 (en) | 2001-11-08 | 2005-07-26 | Arthrocare Corporation | Methods and apparatus for skin treatment |
US7115093B2 (en) | 2001-11-21 | 2006-10-03 | Ge Medical Systems Global Technology Company, Llc | Method and system for PDA-based ultrasound system |
US7317818B2 (en) | 2001-11-26 | 2008-01-08 | L'ORéAL S.A. | Method of enabling an analysis of an external body portion |
ATE404120T1 (en) | 2001-11-30 | 2008-08-15 | Petro Moilanen | METHOD FOR THE NON-INVASIVE EXAMINATION OF BONE |
US6554771B1 (en) | 2001-12-18 | 2003-04-29 | Koninklijke Philips Electronics N.V. | Position sensor in ultrasound transducer probe |
US6746402B2 (en) | 2002-01-02 | 2004-06-08 | E. Tuncay Ustuner | Ultrasound system and method |
JP2003204982A (en) | 2002-01-09 | 2003-07-22 | Byeong Gon Kim | Abdomen warming and vibrating belt |
SE520857C2 (en) | 2002-01-15 | 2003-09-02 | Ultrazonix Dnt Ab | Device with both therapeutic and diagnostic sensors for mini-invasive ultrasound treatment of an object, where the therapeutic sensor is thermally insulated |
TWI220386B (en) | 2002-01-21 | 2004-08-21 | Matsushita Electric Works Ltd | Ultrasonic transdermal permeation device |
EP1470546B1 (en) | 2002-01-29 | 2013-11-27 | SRA Developments Limited | Method and apparatus for focussing ultrasonic energy |
DK1474690T3 (en) | 2002-02-07 | 2011-01-10 | Boehringer Ingelheim Ca Ltd | E2 shear assay for identification of inhibitors of HPV |
JP4265139B2 (en) | 2002-02-18 | 2009-05-20 | コニカミノルタホールディングス株式会社 | Radiation image conversion panel and radiation image reading apparatus |
US7258674B2 (en) | 2002-02-20 | 2007-08-21 | Liposonix, Inc. | Ultrasonic treatment and imaging of adipose tissue |
JP2003248097A (en) | 2002-02-25 | 2003-09-05 | Konica Corp | Radiation image conversion panel and its production method |
US6648839B2 (en) | 2002-02-28 | 2003-11-18 | Misonix, Incorporated | Ultrasonic medical treatment device for RF cauterization and related method |
US20030171701A1 (en) | 2002-03-06 | 2003-09-11 | Eilaz Babaev | Ultrasonic method and device for lypolytic therapy |
US6824516B2 (en) | 2002-03-11 | 2004-11-30 | Medsci Technologies, Inc. | System for examining, mapping, diagnosing, and treating diseases of the prostate |
US8840608B2 (en) | 2002-03-15 | 2014-09-23 | The General Hospital Corporation | Methods and devices for selective disruption of fatty tissue by controlled cooling |
IL148791A0 (en) | 2002-03-20 | 2002-09-12 | Yoni Iger | Method and apparatus for altering activity of tissue layers |
US6662054B2 (en) | 2002-03-26 | 2003-12-09 | Syneron Medical Ltd. | Method and system for treating skin |
US7534211B2 (en) | 2002-03-29 | 2009-05-19 | Sonosite, Inc. | Modular apparatus for diagnostic ultrasound |
US6887239B2 (en) | 2002-04-17 | 2005-05-03 | Sontra Medical Inc. | Preparation for transmission and reception of electrical signals |
US7000126B2 (en) | 2002-04-18 | 2006-02-14 | Intel Corporation | Method for media content presentation in consideration of system power |
DE10219297A1 (en) | 2002-04-25 | 2003-11-06 | Laser & Med Tech Gmbh | Medical instrument for generation of scar tissue to stiffen soft tissue, combines an ultrasound generator with a laser so that electromagnetic and or ultrasound energy can be coupled into the tissue via an opto-acoustic coupler |
DE10219217B3 (en) | 2002-04-29 | 2004-02-12 | Creative-Line Gmbh | Object with picture built up from lines, e.g. for decoration, has line pattern eroded into main surface |
US20030236487A1 (en) | 2002-04-29 | 2003-12-25 | Knowlton Edward W. | Method for treatment of tissue with feedback |
US6992305B2 (en) | 2002-05-08 | 2006-01-31 | Konica Corporation | Radiation image converting panel and production method of the same |
US20030212129A1 (en) | 2002-05-13 | 2003-11-13 | Liu Kay Miyakawa | System and method for revitalizing human skin |
US6846290B2 (en) | 2002-05-14 | 2005-01-25 | Riverside Research Institute | Ultrasound method and system |
US7359745B2 (en) | 2002-05-15 | 2008-04-15 | Case Western Reserve University | Method to correct magnetic field/phase variations in proton resonance frequency shift thermometry in magnetic resonance imaging |
EP1551303A4 (en) | 2002-05-16 | 2009-03-18 | Karmanos B A Cancer Inst | Method and system for combined diagnostic and therapeutic ultrasound system incorporating noninvasive thermometry, ablation control and automation |
US7967839B2 (en) | 2002-05-20 | 2011-06-28 | Rocky Mountain Biosystems, Inc. | Electromagnetic treatment of tissues and cells |
US6958043B2 (en) | 2002-05-21 | 2005-10-25 | Medtronic Xomed, Inc. | Apparatus and method for displacing the partition between the middle ear and the inner ear using a manually powered device |
US7179238B2 (en) | 2002-05-21 | 2007-02-20 | Medtronic Xomed, Inc. | Apparatus and methods for directly displacing the partition between the middle ear and inner ear at an infrasonic frequency |
US20070038206A1 (en) | 2004-12-09 | 2007-02-15 | Palomar Medical Technologies, Inc. | Photocosmetic device |
US7070565B2 (en) | 2002-05-30 | 2006-07-04 | University Of Washington | Solid hydrogel coupling for ultrasound imaging and therapy |
US20030233085A1 (en) | 2002-06-18 | 2003-12-18 | Pedro Giammarusti | Optimization of transcutaneous active permeation of compounds through the synergistic use of ultrasonically generated mechanical abrasion of the skin, chemical enhancers and simultaneous application of sonophoresis, iontophoresis, electroporation, mechanical vibrations and magnetophoresis through single application devices |
BR0312430A (en) | 2002-06-19 | 2005-04-26 | Palomar Medical Tech Inc | Method and apparatus for treating skin and subcutaneous conditions |
BR0215785A (en) | 2002-06-25 | 2006-06-06 | Ultrashape Inc | Useful devices and methodologies for body aesthetics |
US20040001809A1 (en) * | 2002-06-26 | 2004-01-01 | Pharmasonics, Inc. | Methods and apparatus for enhancing a response to nucleic acid vaccines |
US20040082859A1 (en) | 2002-07-01 | 2004-04-29 | Alan Schaer | Method and apparatus employing ultrasound energy to treat body sphincters |
US20040049134A1 (en) | 2002-07-02 | 2004-03-11 | Tosaya Carol A. | System and methods for treatment of alzheimer's and other deposition-related disorders of the brain |
KR100872242B1 (en) | 2002-08-29 | 2008-12-05 | 엘지전자 주식회사 | Computor of Portable composition type |
WO2004023235A2 (en) * | 2002-09-03 | 2004-03-18 | Healthpia Co., Ltd. | Integrated beauty care apparatus |
US20040122493A1 (en) | 2002-09-09 | 2004-06-24 | Kabushiki Kaisha Toshiba | Ultrasonic irradiation apparatus |
JP2004147719A (en) | 2002-10-29 | 2004-05-27 | Toshiba Corp | Ultrasonic wave irradiation apparatus |
US7234106B2 (en) | 2002-09-10 | 2007-06-19 | Simske Steven J | System for and method of generating image annotation information |
US20070219605A1 (en) | 2006-03-20 | 2007-09-20 | Palomar Medical Technologies, Inc. | Treatment of tissue volume with radiant energy |
US6709392B1 (en) | 2002-10-10 | 2004-03-23 | Koninklijke Philips Electronics N.V. | Imaging ultrasound transducer temperature control system and method using feedback |
US6669638B1 (en) | 2002-10-10 | 2003-12-30 | Koninklijke Philips Electronics N.V. | Imaging ultrasound transducer temperature control system and method |
US7004940B2 (en) | 2002-10-10 | 2006-02-28 | Ethicon, Inc. | Devices for performing thermal ablation having movable ultrasound transducers |
US6921371B2 (en) | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
US6860852B2 (en) | 2002-10-25 | 2005-03-01 | Compex Medical S.A. | Ultrasound therapeutic device |
JP2006505321A (en) | 2002-11-06 | 2006-02-16 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Phased array acoustic system for 3D imaging of moving parts |
US6629929B1 (en) * | 2002-11-08 | 2003-10-07 | Koninklijke Philips Electronics N.V. | Method and apparatus for automatically setting the transmit aperture and apodization of an ultrasound transducer array |
US7156816B2 (en) | 2002-11-26 | 2007-01-02 | Biosense, Inc. | Ultrasound pulmonary vein isolation |
US7676047B2 (en) | 2002-12-03 | 2010-03-09 | Bose Corporation | Electroacoustical transducing with low frequency augmenting devices |
US8088067B2 (en) | 2002-12-23 | 2012-01-03 | Insightec Ltd. | Tissue aberration corrections in ultrasound therapy |
US20040143297A1 (en) | 2003-01-21 | 2004-07-22 | Maynard Ramsey | Advanced automatic external defibrillator powered by alternative and optionally multiple electrical power sources and a new business method for single use AED distribution and refurbishment |
US7150716B2 (en) | 2003-02-20 | 2006-12-19 | Siemens Medical Solutions Usa, Inc. | Measuring transducer movement methods and systems for multi-dimensional ultrasound imaging |
US20030191396A1 (en) | 2003-03-10 | 2003-10-09 | Sanghvi Narendra T | Tissue treatment method and apparatus |
AU2004218906B2 (en) | 2003-03-13 | 2009-11-05 | Real Aesthetics Ltd. | Cellulite ultrasound treatment |
US6918907B2 (en) | 2003-03-13 | 2005-07-19 | Boston Scientific Scimed, Inc. | Surface electrode multiple mode operation |
US6733449B1 (en) | 2003-03-20 | 2004-05-11 | Siemens Medical Solutions Usa, Inc. | System and method for real-time streaming of ultrasound data to a diagnostic medical ultrasound streaming application |
JP2004297951A (en) | 2003-03-27 | 2004-10-21 | Olympus Corp | Ultrasonic vibrator and ultrasonic motor |
US20040206365A1 (en) | 2003-03-31 | 2004-10-21 | Knowlton Edward Wells | Method for treatment of tissue |
US9149322B2 (en) | 2003-03-31 | 2015-10-06 | Edward Wells Knowlton | Method for treatment of tissue |
US7273459B2 (en) | 2003-03-31 | 2007-09-25 | Liposonix, Inc. | Vortex transducer |
ATE411836T1 (en) | 2003-05-19 | 2008-11-15 | Ust Inc | GEOMETRIC SHAPED HYDROGEL COUPLING BODY FOR HIGH-INTENSITY FOCUSED ULTRASOUND TREATMENT |
EP1628577A2 (en) | 2003-05-21 | 2006-03-01 | Dietrich, René | Ultrasound coupling medium for use in medical diagnostics |
ITSV20030023A1 (en) | 2003-05-22 | 2004-11-23 | Esaote Spa | METHOD FOR THE OPTIMIZATION OF ULTRASONIC IMPULSES IN |
US6896657B2 (en) | 2003-05-23 | 2005-05-24 | Scimed Life Systems, Inc. | Method and system for registering ultrasound image in three-dimensional coordinate system |
JP4041014B2 (en) | 2003-06-06 | 2008-01-30 | オリンパス株式会社 | Ultrasonic surgical device |
EP1635709B1 (en) | 2003-06-12 | 2013-10-30 | Bracco Suisse SA | Blood flow estimates through replenishment curve fitting in ultrasound contrast imaging |
JP4165562B2 (en) | 2003-06-13 | 2008-10-15 | 松下電工株式会社 | Ultrasonic imparting skin care device |
US7074218B2 (en) | 2003-06-30 | 2006-07-11 | Ethicon, Inc. | Multi-modality ablation device |
US7303555B2 (en) | 2003-06-30 | 2007-12-04 | Depuy Products, Inc. | Imaging and therapeutic procedure for carpal tunnel syndrome |
US20050033316A1 (en) | 2003-07-14 | 2005-02-10 | M. Glen Kertz | Ultrasonic skin cleaner |
US20050070961A1 (en) | 2003-07-15 | 2005-03-31 | Terumo Kabushiki Kaisha | Energy treatment apparatus |
JP4472395B2 (en) | 2003-08-07 | 2010-06-02 | オリンパス株式会社 | Ultrasonic surgery system |
JP4638819B2 (en) | 2003-08-08 | 2011-02-23 | パナソニック株式会社 | Ultrasonic diagnostic equipment |
US7398116B2 (en) | 2003-08-11 | 2008-07-08 | Veran Medical Technologies, Inc. | Methods, apparatuses, and systems useful in conducting image guided interventions |
US7294125B2 (en) * | 2003-08-22 | 2007-11-13 | Scimed Life Systems, Inc. | Methods of delivering energy to body portions to produce a therapeutic response |
US20050080469A1 (en) | 2003-09-04 | 2005-04-14 | Larson Eugene A. | Treatment of cardiac arrhythmia utilizing ultrasound |
AU2004272023B2 (en) | 2003-09-08 | 2008-06-26 | Board Of Trustees Of The University Of Arkansas | Ultrasound apparatus and method for augmented clot lysis |
DE20314479U1 (en) | 2003-09-13 | 2004-02-12 | Peter Krauth Gmbh | Low frequency ultrasound treatment unit for wet use has electronic unit with detachable connection to sealed titanium or stainless steel membrane ultrasound head |
FR2859983B1 (en) | 2003-09-22 | 2006-03-10 | Valois Sas | FIXING DEVICE AND MOUNTING METHOD FOR FIXING A DISTRIBUTION MEMBER ON A TANK OPENING |
US20050074407A1 (en) | 2003-10-01 | 2005-04-07 | Sonotech, Inc. | PVP and PVA as in vivo biocompatible acoustic coupling medium |
US7358831B2 (en) | 2003-10-30 | 2008-04-15 | Avago Technologies Wireless Ip (Singapore) Pte. Ltd. | Film bulk acoustic resonator (FBAR) devices with simplified packaging |
CA2542393C (en) | 2003-11-04 | 2009-10-13 | University Of Washington | Toothbrush employing an acoustic waveguide |
US20050113689A1 (en) | 2003-11-21 | 2005-05-26 | Arthur Gritzky | Method and apparatus for performing multi-mode imaging |
US8206299B2 (en) | 2003-12-16 | 2012-06-26 | University Of Washington | Image guided high intensity focused ultrasound treatment of nerves |
US7173453B2 (en) | 2003-12-18 | 2007-02-06 | Cypress Semiconductor Corp. | Method and circuit for translating a differential signal to complementary CMOS levels |
US20050137656A1 (en) | 2003-12-23 | 2005-06-23 | American Environmental Systems, Inc. | Acoustic-optical therapeutical devices and methods |
US20050154308A1 (en) | 2003-12-30 | 2005-07-14 | Liposonix, Inc. | Disposable transducer seal |
US20050193451A1 (en) | 2003-12-30 | 2005-09-01 | Liposonix, Inc. | Articulating arm for medical procedures |
KR20060113930A (en) | 2003-12-30 | 2006-11-03 | 리포소닉스 인코포레이티드 | Systems and methods for the destruction of adipose tissue |
EP1699407A4 (en) | 2003-12-30 | 2010-12-01 | Medicis Technologies Corp | Ultrasound therapy head with movement control |
US7857773B2 (en) | 2003-12-30 | 2010-12-28 | Medicis Technologies Corporation | Apparatus and methods for the destruction of adipose tissue |
JP2007516809A (en) | 2003-12-30 | 2007-06-28 | ライポソニックス, インコーポレイテッド | Ultrasonic transducer components |
US20050154332A1 (en) | 2004-01-12 | 2005-07-14 | Onda | Methods and systems for removing hair using focused acoustic energy |
JP2007520307A (en) | 2004-02-06 | 2007-07-26 | テクニオン リサーチ アンド ディベロップメント ファウンデーション リミティド | Microbubble local formation method, cavitation effect control and heating effect control by using enhanced ultrasound |
EP1718366A4 (en) * | 2004-02-06 | 2007-11-21 | Daniel Barolet | Method and device for the treatment of mammalian tissues |
JP2005245521A (en) | 2004-03-01 | 2005-09-15 | Japan Natural Laboratory Co Ltd | Skin care or beauty system using ion introducer, ultrasonic wave facial treatment device, and cosmetic additives |
WO2005083881A1 (en) | 2004-03-02 | 2005-09-09 | Murata Manufacturing Co., Ltd. | Surface acoustic wave device |
WO2005090978A1 (en) | 2004-03-12 | 2005-09-29 | University Of Virginia Patent Foundation | Electron transfer dissociation for biopolymer sequence analysis |
US20050228281A1 (en) | 2004-03-31 | 2005-10-13 | Nefos Thomas P | Handheld diagnostic ultrasound system with head mounted display |
WO2005099369A2 (en) | 2004-04-09 | 2005-10-27 | Palomar Medical Technologies, Inc. | Emr treated islets |
JP4100372B2 (en) | 2004-05-10 | 2008-06-11 | 松下電工株式会社 | Ultrasonic beauty equipment |
US8235909B2 (en) | 2004-05-12 | 2012-08-07 | Guided Therapy Systems, L.L.C. | Method and system for controlled scanning, imaging and/or therapy |
US7951095B2 (en) | 2004-05-20 | 2011-05-31 | Ethicon Endo-Surgery, Inc. | Ultrasound medical system |
US7837675B2 (en) | 2004-07-22 | 2010-11-23 | Shaser, Inc. | Method and device for skin treatment with replaceable photosensitive window |
US7699780B2 (en) | 2004-08-11 | 2010-04-20 | Insightec—Image-Guided Treatment Ltd. | Focused ultrasound system with adaptive anatomical aperture shaping |
US7310928B2 (en) | 2004-08-24 | 2007-12-25 | Curry Janine V | Retractable spurs |
US9011336B2 (en) | 2004-09-16 | 2015-04-21 | Guided Therapy Systems, Llc | Method and system for combined energy therapy profile |
US7824348B2 (en) | 2004-09-16 | 2010-11-02 | Guided Therapy Systems, L.L.C. | System and method for variable depth ultrasound treatment |
US7393325B2 (en) | 2004-09-16 | 2008-07-01 | Guided Therapy Systems, L.L.C. | Method and system for ultrasound treatment with a multi-directional transducer |
US7530958B2 (en) | 2004-09-24 | 2009-05-12 | Guided Therapy Systems, Inc. | Method and system for combined ultrasound treatment |
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US20130096471A1 (en) | 2010-08-02 | 2013-04-18 | Guided Therapy Systems, Llc | Systems and methods for treating injuries to joints and connective tissue |
US20130046209A1 (en) | 2011-07-10 | 2013-02-21 | Guided Therapy Systems, Llc | Systems and methods for improving an outside appearance of skin using ultrasound as an energy source |
US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
US7530356B2 (en) | 2004-10-06 | 2009-05-12 | Guided Therapy Systems, Inc. | Method and system for noninvasive mastopexy |
US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
EP2409730A1 (en) | 2004-10-06 | 2012-01-25 | Guided Therapy Systems, L.L.C. | Method and system for ultrasound tissue treatment |
US7758524B2 (en) | 2004-10-06 | 2010-07-20 | Guided Therapy Systems, L.L.C. | Method and system for ultra-high frequency ultrasound treatment |
US8133180B2 (en) | 2004-10-06 | 2012-03-13 | Guided Therapy Systems, L.L.C. | Method and system for treating cellulite |
US20120046547A1 (en) | 2004-10-06 | 2012-02-23 | Guided Therapy Systems, Llc | System and method for cosmetic treatment |
KR101328103B1 (en) | 2004-10-06 | 2013-11-13 | 가이디드 테라피 시스템스, 엘.엘.씨. | Method and system for noninvasive cosmetic enhancement |
US8690778B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Energy-based tissue tightening |
PT2409731T (en) | 2004-10-06 | 2017-10-23 | Guided Therapy Systems Llc | System for controlled thermal treatment of human superficial tissue |
US20060079868A1 (en) | 2004-10-07 | 2006-04-13 | Guided Therapy Systems, L.L.C. | Method and system for treatment of blood vessel disorders |
US7235592B2 (en) | 2004-10-12 | 2007-06-26 | Zimmer Gmbh | PVA hydrogel |
US20060089688A1 (en) | 2004-10-25 | 2006-04-27 | Dorin Panescu | Method and apparatus to reduce wrinkles through application of radio frequency energy to nerves |
US20060094988A1 (en) | 2004-10-28 | 2006-05-04 | Tosaya Carol A | Ultrasonic apparatus and method for treating obesity or fat-deposits or for delivering cosmetic or other bodily therapy |
US20060122509A1 (en) | 2004-11-24 | 2006-06-08 | Liposonix, Inc. | System and methods for destroying adipose tissue |
US20060116583A1 (en) | 2004-11-26 | 2006-06-01 | Yoichi Ogasawara | Ultrasonic diagnostic apparatus and control method thereof |
US8162858B2 (en) | 2004-12-13 | 2012-04-24 | Us Hifu, Llc | Ultrasonic medical treatment device with variable focal zone |
CN100542635C (en) | 2005-01-10 | 2009-09-23 | 重庆海扶(Hifu)技术有限公司 | High intensity focused ultrasound therapy device and method |
US7918795B2 (en) | 2005-02-02 | 2011-04-05 | Gynesonics, Inc. | Method and device for uterine fibroid treatment |
US7553284B2 (en) | 2005-02-02 | 2009-06-30 | Vaitekunas Jeffrey J | Focused ultrasound for pain reduction |
CN101146574A (en) | 2005-02-06 | 2008-03-19 | 超形态公司 | Non-thermal acoustic tissue modification |
US20060241440A1 (en) | 2005-02-07 | 2006-10-26 | Yoram Eshel | Non-thermal acoustic tissue modification |
US7771418B2 (en) | 2005-03-09 | 2010-08-10 | Sunnybrook Health Sciences Centre | Treatment of diseased tissue using controlled ultrasonic heating |
US7931611B2 (en) * | 2005-03-23 | 2011-04-26 | Misonix, Incorporated | Ultrasonic wound debrider probe and method of use |
US7335997B2 (en) | 2005-03-31 | 2008-02-26 | Ethicon Endo-Surgery, Inc. | System for controlling ultrasonic clamping and cutting instruments |
US7357815B2 (en) * | 2005-04-21 | 2008-04-15 | Micardia Corporation | Dynamically adjustable implants and methods for reshaping tissue |
JP4695188B2 (en) | 2005-04-25 | 2011-06-08 | アーデント サウンド, インコーポレイテッド | Method and apparatus for improving the safety of computer peripherals |
US8454511B2 (en) | 2005-05-27 | 2013-06-04 | Board Of Regents, The University Of Texas System | Magneto-motive ultrasound detection of magnetic nanoparticles |
US7330578B2 (en) | 2005-06-23 | 2008-02-12 | Accuray Inc. | DRR generation and enhancement using a dedicated graphics device |
US7785277B2 (en) | 2005-06-23 | 2010-08-31 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US8128618B2 (en) | 2005-08-03 | 2012-03-06 | Massachusetts Eye & Ear Infirmary | Targeted muscle ablation for reducing signs of aging |
US7621873B2 (en) | 2005-08-17 | 2009-11-24 | University Of Washington | Method and system to synchronize acoustic therapy with ultrasound imaging |
US20070065420A1 (en) | 2005-08-23 | 2007-03-22 | Johnson Lanny L | Ultrasound Therapy Resulting in Bone Marrow Rejuvenation |
US20090093737A1 (en) | 2007-10-09 | 2009-04-09 | Cabochon Aesthetics, Inc. | Ultrasound apparatus with treatment lens |
US20070083120A1 (en) | 2005-09-22 | 2007-04-12 | Cain Charles A | Pulsed cavitational ultrasound therapy |
US8057408B2 (en) | 2005-09-22 | 2011-11-15 | The Regents Of The University Of Michigan | Pulsed cavitational ultrasound therapy |
US8016757B2 (en) * | 2005-09-30 | 2011-09-13 | University Of Washington | Non-invasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound |
US20070078290A1 (en) * | 2005-09-30 | 2007-04-05 | Esenaliev Rinat O | Ultrasound-based treatment methods for therapeutic treatment of skin and subcutaneous tissues |
US20070088346A1 (en) | 2005-10-14 | 2007-04-19 | Mirizzi Michael S | Method and apparatus for varicose vein treatment using acoustic hemostasis |
WO2007047726A2 (en) | 2005-10-20 | 2007-04-26 | The General Hospital Corporation | Non-invasive treatment of fascia |
JP2009514569A (en) | 2005-11-07 | 2009-04-09 | シグノスティックス ピーティーワイ エルティーディー | Ultrasonic measurement system and method |
US20080146970A1 (en) | 2005-12-06 | 2008-06-19 | Julia Therapeutics, Llc | Gel dispensers for treatment of skin with acoustic energy |
US9017717B2 (en) | 2006-01-16 | 2015-04-28 | Peach Technologies Llc | Bandage for facilitating transdermal respiration and healing |
US8133191B2 (en) | 2006-02-16 | 2012-03-13 | Syneron Medical Ltd. | Method and apparatus for treatment of adipose tissue |
US8920320B2 (en) * | 2006-03-10 | 2014-12-30 | Liposonix, Inc. | Methods and apparatus for coupling a HIFU transducer to a skin surface |
ITBO20060221A1 (en) | 2006-03-30 | 2006-06-29 | Massimo Santangelo | METHOD AND EQUIPMENT TO INDUCE OSTEOGENESIS IN A BONE REGION OF THE PATIENT. |
WO2007118229A2 (en) | 2006-04-07 | 2007-10-18 | The General Hospital Corporation | Method and apparatus for selective treatment of biological tissue using ultrasound energy |
JP3123559U (en) | 2006-05-10 | 2006-07-20 | ニチハ株式会社 | Makeup corner material |
US20070264625A1 (en) | 2006-05-11 | 2007-11-15 | Reliant Technologies, Inc. | Apparatus and Method for Ablation-Related Dermatological Treatment of Selected Targets |
US20080039724A1 (en) | 2006-08-10 | 2008-02-14 | Ralf Seip | Ultrasound transducer with improved imaging |
CN101522263A (en) | 2006-08-25 | 2009-09-02 | 艾拉兹·巴巴耶夫 | Portable ultrasound device for the treatment of wounds |
FR2905277B1 (en) * | 2006-08-29 | 2009-04-17 | Centre Nat Rech Scient | DEVICE FOR THE VOLUMIC TREATMENT OF BIOLOGICAL TISSUES |
US20080195000A1 (en) | 2006-09-06 | 2008-08-14 | Spooner Gregory J R | System and Method for Dermatological Treatment Using Ultrasound |
US8262591B2 (en) | 2006-09-07 | 2012-09-11 | Nivasonix, Llc | External ultrasound lipoplasty |
US7955281B2 (en) | 2006-09-07 | 2011-06-07 | Nivasonix, Llc | External ultrasound lipoplasty |
US9566454B2 (en) * | 2006-09-18 | 2017-02-14 | Guided Therapy Systems, Llc | Method and sysem for non-ablative acne treatment and prevention |
ES2579765T3 (en) | 2006-09-19 | 2016-08-16 | Guided Therapy Systems, L.L.C. | System for the treatment of muscle, tendon, ligamentous and cartilaginous tissue |
US9241683B2 (en) | 2006-10-04 | 2016-01-26 | Ardent Sound Inc. | Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid |
US20080183077A1 (en) | 2006-10-19 | 2008-07-31 | Siemens Corporate Research, Inc. | High intensity focused ultrasound path determination |
US9492686B2 (en) | 2006-12-04 | 2016-11-15 | Koninklijke Philips N.V. | Devices and methods for treatment of skin conditions |
US8382689B2 (en) | 2007-02-08 | 2013-02-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Device and method for high intensity focused ultrasound ablation with acoustic lens |
US8231533B2 (en) * | 2007-02-16 | 2012-07-31 | Buchalter Neal | Ultrasound coupling device |
DK1970059T3 (en) | 2007-03-12 | 2009-12-21 | Dobavet Gmbh | Calcium dobesilate drug for the treatment and prophylaxis of tendon disorders |
WO2008114255A1 (en) | 2007-03-19 | 2008-09-25 | Syneron Medical Ltd. | Method and device for soft tissue destruction |
US20080243035A1 (en) | 2007-03-26 | 2008-10-02 | Liposonix, Inc. | Interchangeable high intensity focused ultrasound transducer |
EP2142129A4 (en) | 2007-04-19 | 2011-04-20 | Miramar Labs Inc | Methods and apparatus for reducing sweat production |
US8038619B2 (en) | 2007-04-30 | 2011-10-18 | General Electric Company | Motor driver for ultrasound system |
ES2685745T3 (en) | 2007-05-07 | 2018-10-11 | Guided Therapy Systems, L.L.C. | System for a combined energy therapy profile |
JP2010526589A (en) | 2007-05-07 | 2010-08-05 | ガイデッド セラピー システムズ, エル.エル.シー. | Method and system for modulating a mediant using acoustic energy |
DK2152167T3 (en) | 2007-05-07 | 2018-12-10 | Guided Therapy Systems Llc | Methods and systems for coupling and focusing acoustic energy using a coupling element |
RU2502470C2 (en) | 2007-06-01 | 2013-12-27 | Конинклейке Филипс Электроникс, Н.В. | Light-weight wireless ultrasonic sensor |
ES2688610T3 (en) | 2007-07-26 | 2018-11-05 | Syneron Medical Ltd. | Equipment for the treatment of tissue with ultrasound |
CA2695780A1 (en) | 2007-08-10 | 2009-02-19 | Eleme Medical Inc. | Multi-module skin or body treatment device and the method of using |
US8235902B2 (en) | 2007-09-11 | 2012-08-07 | Focus Surgery, Inc. | System and method for tissue change monitoring during HIFU treatment |
US20090177123A1 (en) | 2007-12-28 | 2009-07-09 | Celleration, Inc. | Methods for treating inflammatory disorders |
US20090177122A1 (en) | 2007-12-28 | 2009-07-09 | Celleration, Inc. | Methods for treating inflammatory skin disorders |
US20090254008A1 (en) * | 2008-01-29 | 2009-10-08 | Shields Jr Donald J | Systems, devices, and methods to concurrently deliver ultrasound waves having thermal and non-thermal effects |
EP2254665B1 (en) | 2008-02-01 | 2014-07-23 | LipoSonix, Inc. | Therapy head for use with an ultrasound system |
WO2009111793A2 (en) | 2008-03-07 | 2009-09-11 | Myoscience, Inc. | Subdermal tissue remodeling using myostatin, methods and related systems |
US8352015B2 (en) | 2008-05-27 | 2013-01-08 | Kyma Medical Technologies, Ltd. | Location tracking of a metallic object in a living body using a radar detector and guiding an ultrasound probe to direct ultrasound waves at the location |
CN104545998B (en) * | 2008-06-06 | 2020-07-14 | 奥赛拉公司 | System and method for cosmetic treatment and imaging |
US20100022919A1 (en) | 2008-07-22 | 2010-01-28 | Celleration, Inc. | Methods of Skin Grafting Using Ultrasound |
US20100042020A1 (en) | 2008-08-13 | 2010-02-18 | Shmuel Ben-Ezra | Focused energy delivery apparatus method and system |
US20100063422A1 (en) | 2008-09-08 | 2010-03-11 | Sunnybrook Health Sciences Center | Ultrasound therapy transducer head and ultrasound therapy system incorporating the same |
EP2341839B1 (en) * | 2008-09-22 | 2015-10-21 | Vessix Vascular, Inc. | System for vascular ultrasound treatments |
EP2331207B1 (en) * | 2008-10-03 | 2013-12-11 | Mirabilis Medica Inc. | Apparatus for treating tissues with hifu |
US20100130891A1 (en) | 2008-11-21 | 2010-05-27 | Taggart Rebecca M | Wearable Therapeutic Ultrasound Article |
US8585618B2 (en) * | 2008-12-22 | 2013-11-19 | Cutera, Inc. | Broad-area irradiation of small near-field targets using ultrasound |
JP2012513837A (en) * | 2008-12-24 | 2012-06-21 | ガイデッド セラピー システムズ, エルエルシー | Method and system for fat loss and / or cellulite treatment |
US20100191120A1 (en) | 2009-01-28 | 2010-07-29 | General Electric Company | Apparatus and method for controlling an ultrasound system based on contact with an ultrasound probe |
US20100211055A1 (en) * | 2009-02-18 | 2010-08-19 | Shimon Eckhouse | Method for body toning and an integrated data management system for the same |
US8486001B2 (en) * | 2009-03-12 | 2013-07-16 | Tim Weyant | Method of treating capsular contracture |
US20100286518A1 (en) | 2009-05-11 | 2010-11-11 | General Electric Company | Ultrasound system and method to deliver therapy based on user defined treatment spaces |
US8348966B2 (en) | 2009-08-07 | 2013-01-08 | Thayer Intellectual Property, Inc. | Systems and methods for treatment of compressed nerves |
JP5749265B2 (en) * | 2009-08-14 | 2015-07-15 | エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. | Ultrasonic surgical apparatus, silicon waveguide, and method of use thereof |
JP5850837B2 (en) | 2009-08-17 | 2016-02-03 | ヒストソニックス,インコーポレーテッド | Disposable acoustic coupling media container |
US20110264012A1 (en) | 2009-10-23 | 2011-10-27 | Frans Lautzenhiser | Compliant couplant with liquid reservoir for transducer |
US8715186B2 (en) | 2009-11-24 | 2014-05-06 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
US20110190745A1 (en) | 2009-12-04 | 2011-08-04 | Uebelhoer Nathan S | Treatment of sweat glands |
EP2600937B8 (en) | 2010-08-02 | 2024-03-06 | Guided Therapy Systems, L.L.C. | Systems for treating acute and/or chronic injuries in soft tissue |
US9504446B2 (en) | 2010-08-02 | 2016-11-29 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
US8857438B2 (en) | 2010-11-08 | 2014-10-14 | Ulthera, Inc. | Devices and methods for acoustic shielding |
US8900145B2 (en) * | 2011-03-10 | 2014-12-02 | University Of Washington Through Its Center For Commercialization | Ultrasound systems and methods for real-time noninvasive spatial temperature estimation |
US20120296240A1 (en) | 2011-05-20 | 2012-11-22 | Slender Medical Ltd. | Ultrasound eye bag treatment |
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WO2013012641A1 (en) | 2011-07-11 | 2013-01-24 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
US20130066237A1 (en) | 2011-09-09 | 2013-03-14 | Palomar Medical Technologies, Inc. | Methods and devices for inflammation treatment |
US9263663B2 (en) | 2012-04-13 | 2016-02-16 | Ardent Sound, Inc. | Method of making thick film transducer arrays |
WO2014055708A1 (en) | 2012-10-02 | 2014-04-10 | Ardent Sound, Inc. | Motion mechanisms for ultrasound transducer modules |
-
2012
- 2012-07-10 US US13/545,954 patent/US20130046209A1/en not_active Abandoned
- 2012-07-10 KR KR1020147003430A patent/KR102068724B1/en active IP Right Grant
- 2012-07-10 WO PCT/US2012/046125 patent/WO2013009787A2/en active Application Filing
- 2012-07-10 KR KR1020147003464A patent/KR102068728B1/en active IP Right Grant
- 2012-07-10 WO PCT/US2012/046122 patent/WO2013009784A2/en active Application Filing
- 2012-07-10 EP EP12811303.2A patent/EP2739357B1/en active Active
- 2012-07-10 US US13/545,929 patent/US8858471B2/en not_active Expired - Fee Related
- 2012-07-10 WO PCT/US2012/046123 patent/WO2013009785A2/en active Application Filing
- 2012-07-10 EP EP12812022.7A patent/EP2729215A4/en not_active Withdrawn
- 2012-07-10 US US13/545,931 patent/US20130012816A1/en not_active Abandoned
- 2012-07-10 US US13/545,953 patent/US9452302B2/en active Active
-
2014
- 2014-10-14 US US14/513,251 patent/US10226645B2/en active Active
-
2016
- 2016-08-24 US US15/246,199 patent/US10166411B2/en active Active
-
2018
- 2018-12-22 US US16/231,438 patent/US10898735B2/en active Active
-
2020
- 2020-11-25 US US17/104,197 patent/US20210322792A1/en not_active Abandoned
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US20140290368A1 (en) * | 2013-03-28 | 2014-10-02 | Siemens Energy, Inc. | Method and apparatus for remote position tracking of an industrial ultrasound imaging probe |
US11123576B2 (en) * | 2013-12-23 | 2021-09-21 | Theraclion Sa | Device for treatment of a tissue and method of preparation of an image of an image-guided device for treatment of a tissue |
US20220001213A1 (en) * | 2013-12-23 | 2022-01-06 | Theraclion Sa | Device for treatment of a tissue and method of preparation of an image of an image-guided device for treatment of a tissue |
US20170001043A1 (en) * | 2013-12-23 | 2017-01-05 | Theraclion Sa | Device for treatment of a tissue and method of preparation of an image of an image-guided device for treatment of a tissue |
US11351401B2 (en) | 2014-04-18 | 2022-06-07 | Ulthera, Inc. | Band transducer ultrasound therapy |
US10603521B2 (en) | 2014-04-18 | 2020-03-31 | Ulthera, Inc. | Band transducer ultrasound therapy |
US20160067526A1 (en) * | 2014-09-04 | 2016-03-10 | National Yang-Ming University | Method for treating and/or preventing neurodegenerative diseases by using low-intensity pulsed ultrasound (LIPUS) |
US11484724B2 (en) | 2015-09-30 | 2022-11-01 | Btl Medical Solutions A.S. | Methods and devices for tissue treatment using mechanical stimulation and electromagnetic field |
US10112119B2 (en) * | 2015-11-09 | 2018-10-30 | Disney Enterprises, Inc. | Method for modifying local properties of materials |
US11224895B2 (en) | 2016-01-18 | 2022-01-18 | Ulthera, Inc. | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof |
US11241218B2 (en) | 2016-08-16 | 2022-02-08 | Ulthera, Inc. | Systems and methods for cosmetic ultrasound treatment of skin |
US11944849B2 (en) | 2018-02-20 | 2024-04-02 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
WO2023063494A1 (en) * | 2021-10-15 | 2023-04-20 | Lutronic Corporation | Skin treatment apparatus using high-intensity focused ultrasound, control method thereof, and skin treatment method using the same |
US11969609B2 (en) | 2022-12-05 | 2024-04-30 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
Also Published As
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WO2013009785A3 (en) | 2013-04-18 |
US20130012755A1 (en) | 2013-01-10 |
WO2013009785A2 (en) | 2013-01-17 |
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US9452302B2 (en) | 2016-09-27 |
EP2729215A2 (en) | 2014-05-14 |
US20150080771A1 (en) | 2015-03-19 |
US10226645B2 (en) | 2019-03-12 |
US20160361572A1 (en) | 2016-12-15 |
US10898735B2 (en) | 2021-01-26 |
WO2013009784A2 (en) | 2013-01-17 |
EP2739357A2 (en) | 2014-06-11 |
WO2013009787A2 (en) | 2013-01-17 |
KR102068724B1 (en) | 2020-01-21 |
US8858471B2 (en) | 2014-10-14 |
US20130012842A1 (en) | 2013-01-10 |
KR102068728B1 (en) | 2020-01-21 |
KR20140047705A (en) | 2014-04-22 |
EP2729215A4 (en) | 2015-04-15 |
US20190143148A1 (en) | 2019-05-16 |
EP2739357A4 (en) | 2015-04-15 |
US20130012816A1 (en) | 2013-01-10 |
WO2013009787A3 (en) | 2013-04-18 |
WO2013009784A9 (en) | 2013-04-04 |
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