US20150132240A1 - Topical Composition And Method For Skin Treatment - Google Patents
Topical Composition And Method For Skin Treatment Download PDFInfo
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- US20150132240A1 US20150132240A1 US14/079,617 US201314079617A US2015132240A1 US 20150132240 A1 US20150132240 A1 US 20150132240A1 US 201314079617 A US201314079617 A US 201314079617A US 2015132240 A1 US2015132240 A1 US 2015132240A1
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- topical composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
Definitions
- compositions and formulations applied as a skin treatment having a wound healing agent in combination with a wound concealing agent.
- Physicians typically prescribe wound healing ointments and creams to protect and heal wounds caused by injury or by surgical procedure. Swelling, bruising, or scarring that results from an injury or surgery may take weeks or months to heal before the detrimental effects disappear.
- petrolatum based ointments serve to provide a protective barrier to contaminants, but do not allow the skin to breath.
- Water and oil emulsion creams contain moisturizers, but do not include active ingredients to promote healing.
- active healing agents such as nicotinic acid, antibiotics, antioxidants, extracts of various herbs, steroids, genetically engineered polypeptides, nitric oxide, enzymes, matrix metalloproteinase inhibitors, honey and similar substances are known in the art.
- Municipal water derived from river or lake sources and used for the manufacture of skin creams and lotions is subject to agricultural runoff contaminated by pesticides.
- the water may be filtered and chlorinated to disinfect the water, but chlorination of mud related organic components in the water imparts chlorine by products such as chloroform, a carcinogen to the water.
- chlorination of chloroform by aqueous chlorination of organic compounds Chaidou, V. I. Georgakilas, C. Stalikas, M. Saraci and E. S. Lahaniatis, Chemosphere Volume 39, Issue 4, August 1999, Pages 587-594. Chlorination of municipal water is mandated.
- a topical composition for skin treatment comprising a wound healing agent in combination with a wound concealing agent.
- a topical composition for skin treatment comprises a wound healing agent in combination with a wound concealing agent.
- FIG. 1 shows an example of the basic constituents of a topical composition for skin treatment comprising a wound healing agent and a wound concealing agent, in accordance with one embodiment of the present invention.
- FIG. 2 is a flow chart illustrating an example method of formulation of a topical composition for skin treatment comprising a wound healing agent and a wound concealing agent, in accordance with one embodiment of the present invention.
- stirring As used herein the terms stirring, mixing, dispersing, and mingling are generally understood to have the same meaning.
- topical is generally understood to mean applied to body surfaces such as the skin or mucous membranes.
- composition is generally understood to mean a combination of parts or elements that make up something.
- Other terms understood to have a similar meaning as composition include arrangement and configuration.
- a topical composition as used herein may be understood to be an ointment, a cream, a salve, a balm, a liniment, or a lotion that is applied to the skin as a treatment for ailments, abnormalities, swelling, and wounds including cuts, bruises, scars, abrasions, burns, and similar type injuries.
- the topical composition disclosed herein for skin treatment comprises a wound healing agent in combination with a wound concealing agent.
- the topical composition may further include a foundation/base, a thickener/binder, and a preservative/disinfectant.
- the topical composition disclosed herein may be considered is a gel based formulation that is non-clogging to the skin and includes Ceravitae (wound healing agent) with a plant based source of water ( Aloe vera ) and natural based preservative which simultaneously serves as a disinfectant (O-cymen-5-ol), includes a vegetable oil (grape seed oil), and also contains iron oxides and titanium oxide (pigments) as wound concealing agents that are well suited for use during the recovery phase following an injury or surgical procedure.
- Ceravitae wound healing agent
- Aloe vera plant based source of water
- O-cymen-5-ol natural based preservative which simultaneously serves as a disinfectant
- O-cymen-5-ol includes a vegetable oil (grape seed oil), and also contains iron oxides and titanium oxide (pigments) as wound concealing agents that are well suited for use during the recovery phase following an injury or surgical procedure.
- the topical composition may be considered a water in oil emulsion with a natural liquid being supplied by the Aloe vera plant.
- Aloe Barbadensis gel popularly known as Aloe vera
- Aloe vera has long been used to heal wounds, see: “Anti-inflammatory and wound healing activity of a growth substance in Aloe vera ,” Davis, R H: Donato, J J: Hartman, G M: Haas, R C.: J-Am-Podiatr-Med-Assoc. 1994 Feb; 84(2): 77-81.
- aloe accelerates wound healing when compared with mafenide, see “Beneficial effect of Aloe on wound healing in an excisional wound model.” Heggers J P, Kucukcelebi A, Listenbaum D, Stabenau J, Ko F, Broemeling L D, Robson M C, Winters W D, J. Ahern Complement Med. 1996 Summer; 2(2):271-7. This effect appears to be due to an increased collagen activity, which is enhanced by a lectin, consequently improving the collagen matrix and enhancing the breaking strength of the scar.
- Aloe Barbadensis gel is a watery liquid it may be used as a substitute for commercially derived water in making a water/oil emulsion for topical wound use.
- the topical composition for skin treatment may include a skin respiratory factor (Ceravitae) designed to permit, among other things, uninhibited exposure of the treated skin to oxygen from the air to promote oxygenation and healing of the wound.
- Ceravitae is manufactured, prepared, and retained as a trade secret by Oxygenetic Institute, Inc., of Reno N.V., and is a complex ingredient of the topical composition disclosed herein.
- Ceravitae may be considered as a skin respiratory factor and disinfectant designed to increase oxygen uptake and skin cell production as well as promote the healing process.
- Ceravitae contains a live yeast cell derivative/ Aloe vera ( Aloe Barbadensis )/grape seed extract.
- the adaptive skin respiratory factors in the live yeast cell derivative can be extracted from the nucleuses of yeast or Saccharomyces cerevisiae cells after the yeast has been cultured in nutritional media and then stressed by means including, but not limited to heat, oxidant or irradiation by UV radiation. Irradiation and especially elevated temperatures produce stressed proteins in all cells, see (Demple, B. 1998). These stresses cause cellular proteins to lose their three-dimensional structure, and the adapting yeast cells produce heat stressed proteins that are capable of restoring them to the original configuration. If the protoplasm of the cell is concentrated, a yeast extract may be obtained called Adapted Yeast Extract (AYE). The AYE can be prepared as an alcohol extract of viable Saccharomyces lysate.
- AYE By normalizing the structure of matrix cells, AYE stimulates wound oxygen consumption or uptake, epitheliazation, and collagen synthesis. In topical preparations, AYE is characterized and quantified in terms of skin respiratory ability, which is the increased ability to utilize oxygen and produce extracellular matrix.
- AYE-biofactors extracted from Saccharomyces cerevisiae also contain nutrients such as peptides, proteins, amino acids, minerals carbohydrates, nucleic acid, and other genetic products. After processing, AYE-biofactors are clear and sediment-free, retaining the active components without the dark color or odor of the starting material see (Fishman, H. M. 2001 “Yeast Has Applications In The Cosmetics Industry”, HAPPI, July, 42), see also Lods, L., D. Scholz, C. Dres, C. Johnson & G. Brooks. 2000, “Peroxide-Inducible Protective Factors Produced by Saccharomyces Cerevisiae ,” Cosmet & Toil 115(12) 61-6.
- a method or process of formulating the topical composition for skin treatment may include the following steps.
- the foundation/base may include one or more of the following items, Isododecane (Fanning Corp) 14%, butylene ethylene/propylene copolymer (Arch Personal Care) 4%, cyclopentasiloxane and PEG/PPG-20 dimethicone (Botanigenics Inc) 5.00%, grape seed oil 1.00%, and Dioctyl dodecanedioate (Arch Personal care) 2.00%.
- the wound concealing agent may include one or more pigments.
- the one or more pigments may be considered a cosmetic mixture and include titanium dioxide coated with methicone R434 (Sensient Cosmetic Technologie) 9.35%, yellow iron oxide coated with methicone R0242 (Sensient Cosmetic TECH) 0.75%, red iron oxide coated with methicone R0241 (Sensient Cosmetic TECH), 0.28%, black iron oxide coated with methicone R0243 (Sensient Cosmetic TECH) 0.05%.
- the percentages of the one or more pigments may vary from 0.01 to 3% to substantially or generally match a skin color/pigment of a patient, person, or individual designated for treatment with the topical composition.
- a thickener/binder may be mixed into the first container.
- the thickener/binder may include cyclopentasiloxane and disteardimonium hectorite (Elementis Corp) 1.50% and silica (Cabo Sil Corp). Mixing of the entire contents of the first container (foundation/base, wound concealing agent, and thickener/binder) may continue until the constituents are thoroughly mixed, for example, into a homogenous mixture.
- the topical composition disclosed herein may include the use of naturally based materials to prevent infection in the wound.
- One such naturally based material is o-cymen-5-ol.
- O-cymen-5-ol is a homologue of thymol, the active constituent of Thymus vulgaris or Thyme oil.
- One provider of this material is Barnett Products Corp., under the name of NET DTB.
- O-cymen-5-ol kills yeast, mold, and bacteria and is a natural replacement for triclosan. It has a minimum growth inhibitory concentration against bacterial species, yeast, and mold of 0.01% that is superior to parabens, salicylic acid, and benzoic acid.
- the inhibitory values were provided by Barnett Products Corporation, Englewood Cliffs, N.J. 07632.
- the safety of o-cymen-5-ol has been assessed up to 0.5% and typical use is 0.1%.
- the method or process of formulating the topical composition for skin treatment proceeds by adding a preservative/disinfectant to a second container.
- the preservative/disinfectant may include butylene glycol, 2.50% and o-cymen-5-ol (Barnett products NET DTB) 0.10%. Heat is then applied to the contents of the second container at approximately 40° C. to 50° C., and stirring of the contents of the second container is commenced until the contents are dissolved.
- the wound healing agent/tissue rebuilding agent may include one or more of the following items, Aloe vera gel (Aloecorp) 49.5%, Ceravitae (Oxygenetix Institute, Inc.) 2.80%, and salt 1.0%.
- the percentage of Aloe vera may be varied depending on the percentage of iron oxides (pigments) in order to make the total percentage of constituents in the topical composition one hundred percent.
- one or more of the items that constitute the topical composition may be considered to have multiple properties, characteristics, or features.
- grape seed oil is identified as an item used in the foundation/base of the topical composition, but grape seed oil may be also considered as a hydrating agent.
- silica may be considered a hydrating agent.
- Aloe vera gel may be considered a hydrating agent.
- Ceravitae may be considered as a respiratory factor.
- This unique combination of ingredients allows the skin to appear undamaged with the wound concealing agent while simultaneously promoting healing of the wound or injury with the wound healing agent.
Abstract
A topical composition and method for skin treatment including a wound healing agent in combination with a wound concealing agent, is disclosed herein.
Description
- This application claims priority and the benefit of U.S. patent application Ser. No. 12/927,398 filed on Nov. 15, 2010, the disclosure of which is incorporated herein by reference in its entirety.
- The subject matter disclosed herein relates generally to a topical composition and more particularly to compositions and formulations applied as a skin treatment having a wound healing agent in combination with a wound concealing agent.
- Physicians typically prescribe wound healing ointments and creams to protect and heal wounds caused by injury or by surgical procedure. Swelling, bruising, or scarring that results from an injury or surgery may take weeks or months to heal before the detrimental effects disappear.
- During the wound healing process petrolatum based ointments serve to provide a protective barrier to contaminants, but do not allow the skin to breath. Water and oil emulsion creams contain moisturizers, but do not include active ingredients to promote healing.
- Numerous active healing agents such as nicotinic acid, antibiotics, antioxidants, extracts of various herbs, steroids, genetically engineered polypeptides, nitric oxide, enzymes, matrix metalloproteinase inhibitors, honey and similar substances are known in the art.
- Municipal water derived from river or lake sources and used for the manufacture of skin creams and lotions is subject to agricultural runoff contaminated by pesticides. The water may be filtered and chlorinated to disinfect the water, but chlorination of mud related organic components in the water imparts chlorine by products such as chloroform, a carcinogen to the water. See for example, “Formation of chloroform by aqueous chlorination of organic compounds”, Chaidou, V. I. Georgakilas, C. Stalikas, M. Saraci and E. S. Lahaniatis, Chemosphere Volume 39,
Issue 4, August 1999, Pages 587-594. Chlorination of municipal water is mandated. - As such, there is a need for a topical composition for skin treatment comprising a wound healing agent in combination with a wound concealing agent.
- For the purpose of summarizing the claimed subject matter certain embodiments have been described. It is to be understood that not all disclosed objects may be achieved in accordance with any particular embodiment. Thus, for example, those skilled in the art will recognize that the composition and method described herein may be embodied or carried out in a manner that achieves or optimizes one objective as taught herein without necessarily achieving other objectives.
- In one embodiment, a topical composition for skin treatment comprises a wound healing agent in combination with a wound concealing agent.
- Various embodiments will become readily apparent to those skilled in the art from the following detailed description having reference to the attached figure, the subject matter described herein not being limited to any particular embodiment(s) disclosed.
-
FIG. 1 shows an example of the basic constituents of a topical composition for skin treatment comprising a wound healing agent and a wound concealing agent, in accordance with one embodiment of the present invention. -
FIG. 2 is a flow chart illustrating an example method of formulation of a topical composition for skin treatment comprising a wound healing agent and a wound concealing agent, in accordance with one embodiment of the present invention. - Exemplary embodiments will now be described with references to the accompanying figures. The terminology used in the description is not intended to be interpreted in any limited or restrictive manner, simply because it is being utilized in conjunction with a detailed description of certain embodiments. Furthermore, various embodiments (whether or not specifically described herein) may include novel features, no single one of which is solely responsible for its desirable attributes or which is essential to practicing the subject matter described herein.
- As used herein the terms constituent, element, ingredient, part, and item are generally understood to have the same meaning.
- As used herein the terms stirring, mixing, dispersing, and mingling are generally understood to have the same meaning.
- As used herein the terms formulating, creating, preparing, manufacturing, and making are generally understood to have the same meaning.
- As used herein the term topical is generally understood to mean applied to body surfaces such as the skin or mucous membranes.
- As used herein the term composition is generally understood to mean a combination of parts or elements that make up something. Other terms understood to have a similar meaning as composition include arrangement and configuration.
- In this regard, in one embodiment, a topical composition as used herein may be understood to be an ointment, a cream, a salve, a balm, a liniment, or a lotion that is applied to the skin as a treatment for ailments, abnormalities, swelling, and wounds including cuts, bruises, scars, abrasions, burns, and similar type injuries.
- As shown in
FIG. 1 , in one embodiment, the topical composition disclosed herein for skin treatment comprises a wound healing agent in combination with a wound concealing agent. The topical composition may further include a foundation/base, a thickener/binder, and a preservative/disinfectant. - In one example, the topical composition disclosed herein may be considered is a gel based formulation that is non-clogging to the skin and includes Ceravitae (wound healing agent) with a plant based source of water (Aloe vera) and natural based preservative which simultaneously serves as a disinfectant (O-cymen-5-ol), includes a vegetable oil (grape seed oil), and also contains iron oxides and titanium oxide (pigments) as wound concealing agents that are well suited for use during the recovery phase following an injury or surgical procedure.
- In one example, the topical composition may be considered a water in oil emulsion with a natural liquid being supplied by the Aloe vera plant.
- Aloe Barbadensis gel, popularly known as Aloe vera, has long been used to heal wounds, see: “Anti-inflammatory and wound healing activity of a growth substance in Aloe vera,” Davis, R H: Donato, J J: Hartman, G M: Haas, R C.: J-Am-Podiatr-Med-Assoc. 1994 Feb; 84(2): 77-81. In this regard, aloe accelerates wound healing when compared with mafenide, see “Beneficial effect of Aloe on wound healing in an excisional wound model.” Heggers J P, Kucukcelebi A, Listengarten D, Stabenau J, Ko F, Broemeling L D, Robson M C, Winters W D, J. Ahern Complement Med. 1996 Summer; 2(2):271-7. This effect appears to be due to an increased collagen activity, which is enhanced by a lectin, consequently improving the collagen matrix and enhancing the breaking strength of the scar. As the Aloe Barbadensis gel is a watery liquid it may be used as a substitute for commercially derived water in making a water/oil emulsion for topical wound use.
- In contrast to the aforementioned municipal water, water derived from the Aloe plant is comparatively pure and relatively uncontaminated. Although many water retaining plants may be used as a source of water, Aloe has traditional been used most often.
- The topical composition for skin treatment may include a skin respiratory factor (Ceravitae) designed to permit, among other things, uninhibited exposure of the treated skin to oxygen from the air to promote oxygenation and healing of the wound. Ceravitae is manufactured, prepared, and retained as a trade secret by Oxygenetic Institute, Inc., of Reno N.V., and is a complex ingredient of the topical composition disclosed herein. Ceravitae may be considered as a skin respiratory factor and disinfectant designed to increase oxygen uptake and skin cell production as well as promote the healing process. In this regard, Ceravitae contains a live yeast cell derivative/Aloe vera (Aloe Barbadensis)/grape seed extract.
- The adaptive skin respiratory factors in the live yeast cell derivative can be extracted from the nucleuses of yeast or Saccharomyces cerevisiae cells after the yeast has been cultured in nutritional media and then stressed by means including, but not limited to heat, oxidant or irradiation by UV radiation. Irradiation and especially elevated temperatures produce stressed proteins in all cells, see (Demple, B. 1998). These stresses cause cellular proteins to lose their three-dimensional structure, and the adapting yeast cells produce heat stressed proteins that are capable of restoring them to the original configuration. If the protoplasm of the cell is concentrated, a yeast extract may be obtained called Adapted Yeast Extract (AYE). The AYE can be prepared as an alcohol extract of viable Saccharomyces lysate. By normalizing the structure of matrix cells, AYE stimulates wound oxygen consumption or uptake, epitheliazation, and collagen synthesis. In topical preparations, AYE is characterized and quantified in terms of skin respiratory ability, which is the increased ability to utilize oxygen and produce extracellular matrix.
- AYE-biofactors extracted from Saccharomyces cerevisiae also contain nutrients such as peptides, proteins, amino acids, minerals carbohydrates, nucleic acid, and other genetic products. After processing, AYE-biofactors are clear and sediment-free, retaining the active components without the dark color or odor of the starting material see (Fishman, H. M. 2001 “Yeast Has Applications In The Cosmetics Industry”, HAPPI, July, 42), see also Lods, L., D. Scholz, C. Dres, C. Johnson & G. Brooks. 2000, “Peroxide-Inducible Protective Factors Produced by Saccharomyces Cerevisiae,” Cosmet & Toil 115(12) 61-6. See also Fishman, H. M. 2001, “Yeast Has Applications In The Cosmetics Industry”, HAPPI, July, 42). Further, when delivered to the lower strata of the skin, AYE biofactors stimulate oxygen consumption by viable cells, causing cellular proliferation and collagen and elastin synthesis.
- As shown in
FIG. 2 , in one embodiment, a method or process of formulating the topical composition for skin treatment may include the following steps. - Add a foundation/base to a first container. The foundation/base may include one or more of the following items, Isododecane (Fanning Corp) 14%, butylene ethylene/propylene copolymer (Arch Personal Care) 4%, cyclopentasiloxane and PEG/PPG-20 dimethicone (Botanigenics Inc) 5.00%, grape seed oil 1.00%, and Dioctyl dodecanedioate (Arch Personal care) 2.00%.
- Add a wound concealing agent to the first container.
- Stir the wound concealing agent in the first container.
- The wound concealing agent may include one or more pigments. The one or more pigments may be considered a cosmetic mixture and include titanium dioxide coated with methicone R434 (Sensient Cosmetic Technologie) 9.35%, yellow iron oxide coated with methicone R0242 (Sensient Cosmetic Technologie) 0.75%, red iron oxide coated with methicone R0241 (Sensient Cosmetic Technologie), 0.28%, black iron oxide coated with methicone R0243 (Sensient Cosmetic Technologie) 0.05%. The percentages of the one or more pigments may vary from 0.01 to 3% to substantially or generally match a skin color/pigment of a patient, person, or individual designated for treatment with the topical composition.
- Once the one or more pigments are thoroughly mixed, for example, into a homogenous mixture, a thickener/binder may be mixed into the first container. The thickener/binder may include cyclopentasiloxane and disteardimonium hectorite (Elementis Corp) 1.50% and silica (Cabo Sil Corp). Mixing of the entire contents of the first container (foundation/base, wound concealing agent, and thickener/binder) may continue until the constituents are thoroughly mixed, for example, into a homogenous mixture.
- The topical composition disclosed herein may include the use of naturally based materials to prevent infection in the wound. One such naturally based material is o-cymen-5-ol. O-cymen-5-ol is a homologue of thymol, the active constituent of Thymus vulgaris or Thyme oil. One provider of this material is Barnett Products Corp., under the name of NET DTB. O-cymen-5-ol kills yeast, mold, and bacteria and is a natural replacement for triclosan. It has a minimum growth inhibitory concentration against bacterial species, yeast, and mold of 0.01% that is superior to parabens, salicylic acid, and benzoic acid. The inhibitory values were provided by Barnett Products Corporation, Englewood Cliffs, N.J. 07632. The safety of o-cymen-5-ol has been assessed up to 0.5% and typical use is 0.1%.
- The method or process of formulating the topical composition for skin treatment proceeds by adding a preservative/disinfectant to a second container. The preservative/disinfectant may include butylene glycol, 2.50% and o-cymen-5-ol (Barnett products NET DTB) 0.10%. Heat is then applied to the contents of the second container at approximately 40° C. to 50° C., and stirring of the contents of the second container is commenced until the contents are dissolved.
- Add the contents of container B to the contents of container A and stir till the constituents are mixed.
- Add a wound healing agent/tissue rebuilding agent to a third container. The wound healing agent/tissue rebuilding agent may include one or more of the following items, Aloe vera gel (Aloecorp) 49.5%, Ceravitae (Oxygenetix Institute, Inc.) 2.80%, and salt 1.0%.
- The percentage of Aloe vera may be varied depending on the percentage of iron oxides (pigments) in order to make the total percentage of constituents in the topical composition one hundred percent. Once the wound healing agent/tissue rebuilding agent is added and mixed together in the third container, the contents of the third container are added slowly to the contents of the first container, and stirred, for example, with a sweep rotor until a homogeneous ointment, cream, salve, balm, liniment, or lotion is formed.
- Those of ordinary skill in the art will appreciate that the commercially available ingredients listed above are exemplary only, and that the elements in the formulation may be obtained using ingredients other than those listed above. In addition those of ordinary skill in the art will appreciate that the amount of any ingredient or ingredients listed above can be varied depending on the desired thickness, consistency, and ability to spread or apply the final product (topical composition) to the skin.
- Furthermore, those skilled in art will understand that the order of steps in the method or process of formulating the topical composition for skin treatment may be varied and that the order provided above is just one example of the order of steps in the method or process.
- In addition, those skilled in the art will understand that one or more of the items that constitute the topical composition may be considered to have multiple properties, characteristics, or features. For example, grape seed oil is identified as an item used in the foundation/base of the topical composition, but grape seed oil may be also considered as a hydrating agent. Similarly, silica may be considered a hydrating agent. Aloe vera gel may be considered a hydrating agent. Ceravitae may be considered as a respiratory factor.
- This unique combination of ingredients allows the skin to appear undamaged with the wound concealing agent while simultaneously promoting healing of the wound or injury with the wound healing agent.
- The topical composition and methods of the claimed subject matter have been described with some particularity, but the specific designs, constructions and steps disclosed are not to be taken as delimiting of the subject matter. Obvious modifications will make themselves apparent to those of ordinary skill in the art, all of which will not depart from the essence of the claimed subject matter and all such changes and modifications are intended to be encompassed within the appended claims.
Claims (10)
1. A topical composition for skin treatment comprising a wound healing agent in combination with a wound concealing agent.
2. The topical composition of claim 1 , wherein the composition is a gel-based plant derived water composition.
3. The topical composition of claim 2 , where the water is derived from an Aloe vera plant.
4. The topical composition of claim 1 , wherein the composition is one of a homogeneous cream or a homogenous ointment.
5. The topical composition of claim 4 , wherein the wound healing agent includes a disinfectant and a skin tissue rebuilding agent.
6. The topical composition of claim 5 , wherein the disinfectant comprises Butylene Glycol and o-cymen-5-ol, and the skin tissue rebuilding agent comprises Ceravitae.
7. The topical composition of claim 4 , wherein the wound concealing agent is a cosmetic mixture comprising one or more color pigments whose percentage in the mixture is varied so that a resultant cosmetic mixture color substantially matches a color of skin color for treatment.
8. The topical composition of claim 1 , wherein the composition is one of a homogeneous cream or a homogenous ointment comprising a gel-based plant derived water composition,
wherein the wound healing agent is a mixture of a disinfectant and a skin tissue rebuilding agent, and
wherein the wound concealing agent is a cosmetic mixture comprising of one or more color pigments whose percentage in the mixture is varied so that a resultant cosmetic mixture color substantially matches a color skin for treatment.
9. The topical composition of claim 8 , wherein the water is derived from an Aloe vera plant.
10. The topical composition of claim 8 , wherein the disinfectant comprises Butylene Glycol and o-cymen-5-ol, and the skin tissue rebuilding agent comprises Ceravitae.
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US14/079,617 US20150132240A1 (en) | 2010-11-15 | 2013-11-13 | Topical Composition And Method For Skin Treatment |
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US12/927,398 US10279007B2 (en) | 2010-11-15 | 2010-11-15 | Topical treatment method for healing wounds, disinfecting, covering and concealing the wound until healing occurs |
US14/079,617 US20150132240A1 (en) | 2010-11-15 | 2013-11-13 | Topical Composition And Method For Skin Treatment |
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US14/079,617 Abandoned US20150132240A1 (en) | 2010-11-15 | 2013-11-13 | Topical Composition And Method For Skin Treatment |
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US12/927,398 Active 2032-07-29 US10279007B2 (en) | 2010-11-15 | 2010-11-15 | Topical treatment method for healing wounds, disinfecting, covering and concealing the wound until healing occurs |
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US20120164248A1 (en) | 2012-06-28 |
US10279007B2 (en) | 2019-05-07 |
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