US20160015909A1 - System, retainer and method of providing therapeutic treatment for acne - Google Patents
System, retainer and method of providing therapeutic treatment for acne Download PDFInfo
- Publication number
- US20160015909A1 US20160015909A1 US14/801,515 US201514801515A US2016015909A1 US 20160015909 A1 US20160015909 A1 US 20160015909A1 US 201514801515 A US201514801515 A US 201514801515A US 2016015909 A1 US2016015909 A1 US 2016015909A1
- Authority
- US
- United States
- Prior art keywords
- antimicrobial solution
- retainer
- light
- therapeutic treatment
- fiber optic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 25
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- 208000002874 Acne Vulgaris Diseases 0.000 title description 15
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 130
- 239000000835 fiber Substances 0.000 claims abstract description 51
- 239000004599 antimicrobial Substances 0.000 claims abstract description 39
- 238000010438 heat treatment Methods 0.000 claims abstract description 22
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 20
- 239000000969 carrier Substances 0.000 claims description 8
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 8
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 6
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 5
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 5
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 5
- 229940078916 carbamide peroxide Drugs 0.000 claims description 5
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 5
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 4
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- 239000011570 nicotinamide Substances 0.000 claims description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 4
- 229960004889 salicylic acid Drugs 0.000 claims description 4
- UFUVLHLTWXBHGZ-MGZQPHGTSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 UFUVLHLTWXBHGZ-MGZQPHGTSA-N 0.000 claims description 3
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 claims description 3
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 3
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 2
- XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 claims description 2
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- RRZFQNYMUQPMHE-HYEGCIPRSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate;(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C.CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 RRZFQNYMUQPMHE-HYEGCIPRSA-N 0.000 claims 1
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- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical class CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- UFUVLHLTWXBHGZ-UHFFFAOYSA-N [6-[2-chloro-1-[(1-methyl-4-propylpyrrolidine-2-carbonyl)amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1CC(CCC)CC1C(=O)NC(C(C)Cl)C1C(O)C(O)C(OP(O)(O)=O)C(SC)O1 UFUVLHLTWXBHGZ-UHFFFAOYSA-N 0.000 description 1
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Images
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Definitions
- Acne vulgaris is an inflammatory disease of the pilosebaceous glands characterized by an eruption of the skin, often pustular in nature but not suppurative.
- One common bacteria associated with this disease is propionibacterium acnes.
- Acne is a common affliction of the adolescent and affects a small but significant percentage of the adult population.
- Acne lesions are of four basic types: comedones (blackheads or whiteheads), papules, pustules, and cysts (or nodules).
- comedones blackheads or whiteheads
- papules papules
- pustules or nodules
- a retainer for therapeutic treatment may be provided.
- the retainer for therapeutic treatment may include: a retainer that may retain a antimicrobial solution against tissue; a number of heating elements connected to the retainer for therapeutic treatment; a number of power supply cables connected to the number of heating elements; a number of antimicrobial solution delivery elements connected to the retainer for therapeutic treatment that may deliver an antimicrobial solution; a number of tubes having a first end connected to a antimicrobial solution reservoir and a second end connected to a number of antimicrobial solution delivery elements; a number of fiber optic cables having a first end connected to a light source; and a number of light terminations rigidly connected to the retainer for therapeutic treatment and connected to the second end of the fiber optic cable.
- a method of providing therapeutic treatment may include coupling a retainer that may retain an antimicrobial solution against tissue; connecting a number of heating elements connected to the retainer for therapeutic treatment; powering the heating elements; connecting a number of antimicrobial solution delivery elements connected to the retainer for therapeutic treatment; connecting a number of pieces of tubing having a first end connected to an antimicrobial solution reservoir and a second end connected to the number of antimicrobial solution elements; providing a number of fiber optic cables having a first end connected to a light source; connecting a number of light terminations rigidly connected to the retainer for therapeutic treatment and connected to the second end of the fiber optic cable; applying the antimicrobial solution on a tissue to be treated; retaining the antimicrobial solution against the tissue to be treated; providing the selected wavelength of light; bringing the antimicrobial solution to a desired temperature; and irradiating the antimicrobial solution.
- FIG. 1 is a diagram showing an exemplary embodiment of a system, retainer and method of providing therapeutic treatment
- FIG. 2 is a diagram showing another exemplary embodiment of a system, retainer and method of providing therapeutic treatment
- FIG. 3 is a diagram showing an exemplary embodiment of a full body suit retainer
- FIG. 4 is a diagram showing an exemplary embodiment of a bowl retainer
- FIG. 5 is a diagram showing an exemplary embodiment of a catheter retainer.
- FIG. 6 is a diagram showing an exemplary embodiment of a hand held light emitting device
- the word “exemplary” means “serving as an example, instance or illustration.”
- the exemplary embodiments described herein are not limiting, but rather are exemplary only. It should be understood that the described exemplary embodiments are not necessarily to be construed as preferred or advantageous over other exemplary embodiments.
- the terms “exemplary embodiments of the invention”, “exemplary embodiments” or “invention” do not require that all exemplary embodiments of the invention include the discussed feature, advantage or mode of operation.
- a system, retainer and method of providing therapeutic treatment may provide a retainer to hold solutions in contact with tissues while the tissues and solutions may be simultaneously exposed to certain wavelengths of light.
- the antimicrobial solutions may be activated with certain wavelengths of lights and may eliminate or reduce microbes at a higher percentage than the solution alone.
- An exemplary embodiment of this retainer may create a synergistic effect between certain wavelengths of light and antimicrobial solutions that when applied to tissues may eliminate or reduce disease caused by microorganisms.
- An exemplary embodiments of this retainer may consist of a retainer for therapeutic treatment that emits certain wavelengths of light into the solution. When a specific light and solution combination is applied to tissues, a synergistic effect may be created that may reduce, and may eliminate microorganisms that cause disease.
- a layer of antimicrobial solution 102 may be held between the tissue 100 and the retainer for therapeutic treatment 104 .
- one end of a number of fiber optic cables 103 may be rigidly attached to the retainer for therapeutic treatment 104 through a number of fiber optic connection interfaces or plugs 101 .
- the second end of the number of fiber optic cables may be rigidly connected to any desired source including, but not limited to, a light emitting diode (LED) and laser.
- LED light emitting diode
- the activation of the antimicrobial solution by a light of a pre-determined wavelength may create a synergistic antimicrobial effect.
- the retainer 104 may include temperature control elements 106 that warm and further activate the antimicrobial solution layer 102 . It may be further appreciated that the temperature control elements 106 may also cool the antimicrobial solution, or otherwise regulate the temperature of the antimicrobial solution, as desired.
- a number of antimicrobial solution delivery elements 114 may be rigidly connected to the retainer 104 for therapeutic treatment 104 and to a number of tubes 116 .
- a retainer for therapeutic treatment 204 may house a number of heating elements 206 connected to a power supply 210 by a power cable 208 .
- a retainer for therapeutic treatment 204 may house a number of light terminations 201 that may be connected to a light source 205 by optic cable 203 .
- a retainer for therapeutic treatment 204 may house an antimicrobial solution delivery element 214 connected to an antimicrobial solution reservoir 218 though a tubing 216 .
- the retainer for therapeutic treatment 104 may hold solutions in contact with tissues 100 , such as flesh or teeth, while the tissues 100 and solutions 102 may be simultaneously exposed to certain wavelengths of light.
- the retainer for therapeutic treatment 104 may include at least one tooth covering tray that may emit light for oral treatmentscreating a synergistic antimicrobial effect between an antimicrobial solution and a light of certain predetermined wavelengths. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone.
- the retainer 104 may be installed on an arch of one or more human teeth.
- a light source may shine from a light emitting device or from the end of a fiber optic cable.
- the fiber optic cable may have one side exposed down its length.
- An antimicrobial solution 102 may fill a dental arch-shaped tray.
- the light source may be blue, or another certain predetermined wavelength of light that may supercharge the solution, with an exposure from, but not limited to, a few second to several minutes, as desired. It may be appreciated that any desired wavelength or exposure time may be applied.
- an antimicrobial solution 102 may be used without a reservoir.
- the antimicrobial solution 102 may be inserted directly into the body cavity and exposed to light by a fiber optic wand with a number of light emitting fibers.
- a carrier or reservoir may be the solution 102 itself or a gel. This gel may be inserted in a body cavity with a catheter and exposed to the synergizing light by the same catheter or a different catheter.
- the synergizing light may create an antimicrobial effect between an antimicrobial solution and a light of certain predetermined wavelengths. The resulting antimicrobial effect may be greater than the effect of an antimicrobial solution or the light acting alone.
- the antimicrobial solution 102 may be delivered by any desired expedient, including, but not limited to, reservoirs, bandages, gels, solutions, head coverings, wraps, socks, stockings, hats, helmets, mitts, suits, tents, probes, and catheters.
- the retainer for therapeutic treatment may be a light emitting sponge that can apply and hold the solution on the surface of the tissue.
- a full body suit retainer may be provided.
- a full body suit with tubing may carry a light-enhanced antimicrobial mist or solution to a user wearing the suit.
- An embodiment of a suit may include a one-piece garment that generally retains air around the user's body.
- Exemplary embodiments of a full body suit may include a portion that covers at least a user's torso, as desired.
- Exemplary embodiments may further include portions to cover a user's legs, feet, arms, head, or hands, as desired.
- Further exemplary embodiments may have collars, cuffs, or elastic portions that may fit against the user to help retain the antimicrobial solution, as desired.
- the portions may cooperate to provide a garment that may retain the antimicrobial solution within the suit when the suit is worn.
- a fiber optic cable may wrap around the inside of the suit.
- a full body suit may include sleeves with gloves or mittens, pants with feet, and a hood with fiber optic cable spaced along the inner fabric of the suit, or otherwise within or on the fabric.
- gloves, mittens, or feet may help retain the antimicrobial solution within the suit, and may be integrated with the rest of the suit or may be removable.
- Exemplary embodiments of integrated portions may include fiber optic cable, similar to the rest of the suit.
- Exemplary embodiments of removable portions may lack fiber optic cable, or may include fiber optic cable that can be connected to the fiber optic cable in the sleeves or pants, as desired.
- the fiber optic cable may have light terminations spaced along the fiber optic cable inside the suit.
- the fiber optics may irradiate an antimicrobial solution with a light of certain predetermined wavelengths and may create a synergistic antimicrobial effect. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone.
- An exemplary embodiment may include a heating element inside the body suit, such heating wires may be embedded in the fabric of the suit.
- the suit may include an input tube or input tubing to carry antimicrobial solution into the suit, an area within the suit to circulate the antimicrobial solution against the user, and an exhaust tube or exhaust tubing to allow air and the antimicrobial solution out of the suit.
- exemplary embodiments of tubing may include an input tube on one side of the torso and an output tube on the opposite side, such as input and output tubes on opposite shoulders.
- a user may put on the garment, add anti-microbial solution using the input tube, allow the mist to circulate within the suit, and turn on the light source.
- the user may simultaneously input and output antimicrobial solution to circulate through the suit.
- the user may power on the heating element to warm the mist and/or otherwise activate or control any portion of the suit, as desired.
- An embodiment of a medical device 50 may include a full body suit 52 having an integrated torso portion 54 , sleeves 56 , pants 58 , feet 60 , and a hood 62 , and removable gloves 64 or mittens 66 .
- the sleeves 56 may have cuffs 68 to tighten and/or form a seal against the user's wrists.
- the hood 62 may have elastic portions 70 to tighten against the user's face.
- Further exemplary embodiments may include an input tube 72 , such as one located on shoulder of the torso portion 54 , and an exhaust tube 74 on the opposite shoulder of the torso portion 54 .
- Exemplary embodiments may further include a fiber optic cable 76 spaced along the inner fabric of the suit 52 . Fiber optic cable 76 may be coupled to the suit 52 in any desired fashion.
- the retainer may be in the shape of a container and may apply an antimicrobial solution that may be enhanced with light of a predetermined wavelength.
- An exemplary embodiment may include a bowl, such as a round, open-top container that retains an antimicrobial solution.
- the bowl may be made of generally watertight material so it can retain liquid solution.
- a fiber optic cable may wrap all around the inside surface of the bowl, with light terminations spaced along the fiber optic cable.
- the fiber optic cable may have a number of light terminations so that an antimicrobial solution in the bowl is lighted with light from the cable so as to substantially surround an item immersed in the bowl.
- An exemplary embodiment may include a heating element at the bottom of the bowl.
- the bowl may have a stand or base, and the heating element may be located in the base, or any other location, as desired.
- the fiber optic cable may connect through a connection cable to a light source.
- the light source may have an on/off switch and may have a timer control.
- Embodiments may include a control box that includes the light and heating power source, such as batteries or a connection to a power outlet.
- Embodiments of a control box may also include controls for turning the light or heater on or off, setting of timers, and status display.
- a control box may include receptacles or cables for interfacing with the rest of the retainer, such as a combined interface for both fiber optics and heater power.
- the antimicrobial solution may be warmed in the bowl.
- An object or a body part such as fingers may be placed into the antimicrobial solution, and the light source may be turned on.
- the light source may interact with the antimicrobial solution and may create a synergistic antimicrobial effect.
- the resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone.
- the user may utilize a control box, or any other wired or wireless controller, to turn on or off, or set timers for, the light source, the heater power, or both. It may be appreciated that any desired functions may be managed and timed by the control box.
- an embodiment of a medical device 30 may include a bowl 32 with a number of fiber optic cables 34 that may wrap around an inside surface 36 of the bowl 32 .
- the number of fiber optic cable 34 may have any number of light terminations 38 .
- Exemplary embodiments may have a base 40 , which may contain a number of heating elements 42 .
- the fiber optic cable 34 may connect to a number of light sources 44 through a number of fiber optic connection cables 46 .
- the number of light sources 44 may include an off/off switch 48 or a timer control 49 .
- the retainer may include a catheter that can be inserted into a user's body to dispense antimicrobial fluid.
- Embodiments may also dispense other medicines or fluids, or may be used in a surgical procedure, as desired.
- An exemplary embodiment of a catheter may include a light source running into a fiber optic cable, a catheter tube, a mesh to dispense antimicrobial solution, and a termination emitting light.
- the antimicrobial solution may pass into a first end of the catheter tube, which may be a thin tube or canal down the center of the catheter, made of medical grade materials.
- An exemplary embodiment may receive medicine or antimicrobial solution in one end of the tube, which may be dispensed out of a mesh near an opposite or distal end of the tube.
- Additional exemplary embodiments may include an integrated heating element to warm the antimicrobial solution while in use, or a separate heater to warm the antimicrobial solution before use.
- An exemplary embodiment may also include a thin fiber optic cable inside the catheter tube, or the catheter tube itself may be made of fiber optic material so that the tube conducts both light and antimicrobial solution.
- a number of light terminations may be positioned at, or proximate, an end of the tube, near the mesh portion so that the light shines onto the antimicrobial solution when the solution may be dispensed into the user.
- An exemplary embodiment may include a light emitting cable that may be integrated with the catheter, or a light emitting cable that may be separated from the catheter tube carrying the antimicrobial solution.
- the catheter may be inserted into a body cavity, and may be used for purposes such as drainage or administration of therapeutic materials before or after the device may be used to apply antimicrobial solution.
- Antimicrobial solution may be preheated with the separate heating element, pumped into the catheter, and dispensed into the user's body.
- the light may be turned on to supercharge the antimicrobial material while it may be dispensed or immediately after it may be dispensed and the catheter may be left in place until the treatment may be completed.
- the treatment may create a synergistic antimicrobial effect between an antimicrobial solution and a light of certain predetermined wavelengths. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone.
- a retainer 140 may include a catheter 142 having a catheter tube 144 , a mesh dispenser screen 146 , and a fiber optic cable 148 having one or more light terminations .
- a heating element 152 may be external to the catheter tube 144 , and may provide heated antimicrobial solution 154 through an input tube 156 .
- a light source 158 may be connected through a fiber optic connection cable 160 to the fiber optic cable 148 with a fiber optic connection interface 162 .
- the hand held light emitting device 600 may include a handle portion 602 rigidly connected to the first end of a neck 604 .
- the second end of the neck 604 may be rigidly connected to a head portion 606 housing the light source outlet.
- the light source may be situated in the handle portion 604 and the light may be guided through the neck by optical element including, but not limited to, fiber optic and mirrors. It may be further appreciated that the neck 604 may be flexible and orientable.
- the light source may produce a light at a wavelength of about 360 nm to about 600 nm.
- hand held light emitting device 600 may be used to irradiate an antimicrobial solution, thus creating a synergistic reaction with an antimicrobial effect greater than the light or the solution acting alone.
- the hand held light emitting device 600 may be powered by electric power.
- Power sources may include, but may not be limited to, batteries, rechargeable batteries, and grid power supply.
- the handle portion 602 may house any necessary elements required to provide the current and intensity required by the light source, such as electrical transformers and electronic components.
- the hand held light emitting device 600 may be powered with batteries and may optionally require the power supply cable 608 .
- Acne inflammatory disease results in unsightly lesions, particularly on the face, and in some cases results in severe scarring.
- An exemplary embodiment of the system, retainer and method of providing therapeutic treatment may decrease the inflammatory disease and the associated scarring by creating a synergistic antimicrobial effect between an antimicrobial solution and a light of certain predetermined wavelengths. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone.
- the system, retainer and method of providing therapeutic treatment generally referred to in FIGS.
- 1-6 may provide an improved method for the treatment of acne vulgaris involving the periodic application of an antimicrobial solution containing an effective amount of peroxide agents alone or in combination with one or more of a topical antibiotic, topical anesthetic, nicotinic acid, nicotinamide, antimicrobials, salicylic acid, sulfur, retinoids such as 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid, glycolic acid, tretinoin, borax, and additional chemicals useful in the method.
- an antimicrobial solution containing an effective amount of peroxide agents alone or in combination with one or more of a topical antibiotic, topical anesthetic, nicotinic acid, nicotinamide, antimicrobials, salicylic acid, sulfur, retinoids such as 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid
- the system, retainer and method of providing therapeutic treatment may utilize blue light, or another certain predetermined wavelength of light that may supercharge the solution, with an exposure from about a few second to a few minutes.
- the antimicrobial solution may be an H 2 O 2 solution, such as a gel, with concentration of 0.3 mM or any concentration of solution that may be suitable as an antimicrobial agent.
- hydrogen peroxide if used alone may kill 30% of bacteria that may be exposed to it for 20 seconds.
- a 20 seconds irradiation with light of the wavelength from 360 nm to 500 nm may kill 3% of bacteria that may be exposed to it.
- hydrogen peroxide in combination with light of 360 nm to 500 nm may exhibit a synergistic reaction that kills 96% of bacteria exposed to this combination for 20 seconds.
- This solution may work best at a temperature of about 57 degrees Celsius. It may be appreciated that other chemicals may have different preferred temperatures.
- topical solutions including, but not limited to, hydrogen peroxide, carbamide peroxide, benzoyl peroxide and other chemicals deemed effective may be delivered in various organic vehicles or carriers.
- exemplary embodiments of carriers may include a combination of ethyl alcohol and propylene glycol in which the active ingredient may present in the range of from about 0.001% to about 50% by volume of the carrier.
- the pH of the solution may be adjusted so that tissue sensitivity may be minimized while the effectiveness of the solution may not be hampered.
- the temperature of the solution may be adjusted to increase or optimize its effectiveness.
- systemic antimicrobial agents may be used to increase the effectiveness of the treatment.
- the solution may be exposed to light in a wavelength of 360 nm to 600 nm or any other wavelength that proves effective for a certain time that may range from 1 second to 1 minute.
- topical solutions of peroxide compounds may include hydrogen peroxide and/or carbamide peroxide and/or benzoyl peroxide in various organic carriers in concentrations that may range from about 0.001% to about 50% by volume of the carrier.
- the antimicrobial solution may be incorporated into various vehicles or carriers including solutions, lotions, creams, gels, mists, pastes and ointments along with one or more of the following ingredients: nicotinic acid or nicotinamide that may be present in concentrations from about 0.001% to 30% by volume of the carrier.
- the antimicrobial solution may include erythromycin base in concentrations that may present from about 0.001% to about 30% by volume of the carrier.
- the antimicrobial solution may contain clindamycin phosphate methyl 7-chloro-6,7,8-trideoxy-6-(1-5 methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo- ⁇ -D-galacto-octopyranoside 2-(dihydrogen phosphate) with a concentration from about 0.001 to 30% by volume of carrier.
- the antimicrobial solution may contain tetracycline hydrochloride in concentrations of from 0.001 to 30% by volume of the carrier; retinoids such as 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid; It may be appreciated that the antimicrobial solution may contain any desired compounds deemed effective in treating acne vulgaris.
- the antimicrobial solution carriers may include combinations of ethyl alcohol and propylene glycol, surface active agents such as lauryl ethers and lauryl esters, and other carriers effective for the desired purposes.
- the antimicrobial solution may include a light activated pigment that may fluoresce when exposed to the wavelength of light used in the treatment. This pigment may indicate to the user that the synergistic effect may be occurring.
- Another exemplary embodiment may describe a method of decreasing open and closed comedones and associated inflammation in patients infected with acne vulgaris by topically administering a therapeutically effective amount of peroxide compounds and other therapeutic chemicals that together may form a solution that may be an effective antimicrobial compound for treating acne vulgaris.
- This solution once applied, may be exposed to a wavelength of light, for example using embodiments described herein, that may create a synergistic antimicrobial effect that reduces or eliminates bacteria causing acne vulgaris.
- This synergistic antimicrobial effect may be greater than the solution's antimicrobial effect or the light's antimicrobial effect if they were used separately.
- an about 3% solution of hydrogen peroxide in a gel carrier may be prepared. Twice daily topical applications of this solution may be administered to an infected area on a patient suffering from acne vulgaris. After application, the solution may be exposed to light with a wavelength of about 360 nm to about 500 nm for 20 seconds (or some other amount of time) creating a synergistic effect that may be greater than 10 irradiations with the light or 10 applications the antimicrobial solution alone. The light may be applied by a LED device exposing the patient's entire infected area at one time. The solution may be then rinsed off with clean water. After two weeks of treatment, the comedones count on the patient, and the inflamed areas that result from an acne infection may have measurably declined.
- a solution of containing chemical species including, but limited to, about 3% hydrogen peroxide, about 3% benzoyl peroxide, and salicylic acid may be combined in a cream form.
- This solution may be buffered to a pH of about 6.
- the cream may be applied to areas infected with acne vulgaris on a patient daily. Once the cream is applied, it may be exposed to a 10 watt light source emitting at wavelengths from about 410 nm to about 500 nm thus creating a synergistic effect between the solution and the light causing a greater reduction in microbes than with the light or with the solution acting alone.
- the retainer may have a number of terminations having a diameter of about 15 mm. This particular size would enable the patient to target small areas.
- the diameter of the termination may have any desired value.
- the exposure time of the light may be about one minute. However, it may be appreciated that any desired duration of treatment may be selected. This exemplary embodiment may be used to maintain an area that once exhibited an active acne vulgaris infection.
- a solution containing chemical species including, but not limited to, about 15% carbamide peroxide, about 2.5% clindamycin phosphate (Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo- ⁇ -D-galacto-octopyranoside 2-(dihydrogen phosphate)) and tretinoin may be combined in a gel-form carrier.
- the carrier gel may be heated to about 40 degrees Celsius.
- the warmed solution may help to open the patient's pores once it is applied to the infected area. This solution may be applied three times per day.
- the infected area may be exposed to a light of a wavelength from about 410 nm to about 500 nm by a number of light terminations that would expose an area with a diameter of about 30 centimeters.
- the infected area and solution may be exposed to this certain wavelength of light for about 30 seconds.
- the synergistic effect of the light and solution that may be warmed may be greater than the effect of the light or the solution acting individually.
Abstract
According to an exemplary embodiment, a retainer for therapeutic treatment may be provided. The retainer for therapeutic treatment may include: a retainer that may retain a antimicrobial solution against tissue; a number of heating elements connected to the retainer for therapeutic treatment; a number of power supply cables connected to the number of heating elements; a number of antimicrobial solution delivery elements connected to the retainer for therapeutic treatment that may deliver an antimicrobial solution; a number of pieces of tubing having a first end connected to a antimicrobial solution reservoir and a second end connected to a number of antimicrobial solution delivery elements; a number of fiber optic cables having a first end connected to a light source; and a number of light terminations rigidly connected to the retainer for therapeutic treatment and connected to the second end of the fiber optic cable.
Description
- This application claims the benefit of the filing date of U.S. Patent Application Ser. No. 62/026,498, filed Jul. 18, 2014, which is incorporated herein by reference in its entirety.
- Acne vulgaris is an inflammatory disease of the pilosebaceous glands characterized by an eruption of the skin, often pustular in nature but not suppurative. One common bacteria associated with this disease is propionibacterium acnes. Acne is a common affliction of the adolescent and affects a small but significant percentage of the adult population. Acne lesions are of four basic types: comedones (blackheads or whiteheads), papules, pustules, and cysts (or nodules). Acne inflammatory disease may result in unsightly lesions, particularly on the face, and in some cases may result in severe scarring.
- According to an exemplary embodiment, a retainer for therapeutic treatment may be provided. The retainer for therapeutic treatment may include: a retainer that may retain a antimicrobial solution against tissue; a number of heating elements connected to the retainer for therapeutic treatment; a number of power supply cables connected to the number of heating elements; a number of antimicrobial solution delivery elements connected to the retainer for therapeutic treatment that may deliver an antimicrobial solution; a number of tubes having a first end connected to a antimicrobial solution reservoir and a second end connected to a number of antimicrobial solution delivery elements; a number of fiber optic cables having a first end connected to a light source; and a number of light terminations rigidly connected to the retainer for therapeutic treatment and connected to the second end of the fiber optic cable.
- According to another exemplary embodiment, a method of providing therapeutic treatment may be provided. The method of providing therapeutic treatment may include coupling a retainer that may retain an antimicrobial solution against tissue; connecting a number of heating elements connected to the retainer for therapeutic treatment; powering the heating elements; connecting a number of antimicrobial solution delivery elements connected to the retainer for therapeutic treatment; connecting a number of pieces of tubing having a first end connected to an antimicrobial solution reservoir and a second end connected to the number of antimicrobial solution elements; providing a number of fiber optic cables having a first end connected to a light source; connecting a number of light terminations rigidly connected to the retainer for therapeutic treatment and connected to the second end of the fiber optic cable; applying the antimicrobial solution on a tissue to be treated; retaining the antimicrobial solution against the tissue to be treated; providing the selected wavelength of light; bringing the antimicrobial solution to a desired temperature; and irradiating the antimicrobial solution.
- Advantages of exemplary embodiments of the system, retainer and method of providing therapeutic treatment will be apparent from the following detailed description of the exemplary embodiments. The following detailed description should be considered in conjunction with the accompanying figures in which:
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FIG. 1 is a diagram showing an exemplary embodiment of a system, retainer and method of providing therapeutic treatment; -
FIG. 2 is a diagram showing another exemplary embodiment of a system, retainer and method of providing therapeutic treatment; -
FIG. 3 is a diagram showing an exemplary embodiment of a full body suit retainer; -
FIG. 4 is a diagram showing an exemplary embodiment of a bowl retainer; and -
FIG. 5 is a diagram showing an exemplary embodiment of a catheter retainer. -
FIG. 6 is a diagram showing an exemplary embodiment of a hand held light emitting device - Aspects of the present invention are disclosed in the following description and related figures directed to specific exemplary embodiments of the invention. Those skilled in the art will recognize that alternate exemplary embodiments may be devised without departing from the spirit or the scope of the claims. Additionally, well-known elements of exemplary embodiments of the invention will not be described in detail or will be omitted so as not to obscure the relevant details of the invention.
- As used herein, the word “exemplary” means “serving as an example, instance or illustration.” The exemplary embodiments described herein are not limiting, but rather are exemplary only. It should be understood that the described exemplary embodiments are not necessarily to be construed as preferred or advantageous over other exemplary embodiments. Moreover, the terms “exemplary embodiments of the invention”, “exemplary embodiments” or “invention” do not require that all exemplary embodiments of the invention include the discussed feature, advantage or mode of operation.
- In an exemplary embodiment, and generally referring to the figures, a system, retainer and method of providing therapeutic treatment may provide a retainer to hold solutions in contact with tissues while the tissues and solutions may be simultaneously exposed to certain wavelengths of light. The antimicrobial solutions may be activated with certain wavelengths of lights and may eliminate or reduce microbes at a higher percentage than the solution alone. An exemplary embodiment of this retainer may create a synergistic effect between certain wavelengths of light and antimicrobial solutions that when applied to tissues may eliminate or reduce disease caused by microorganisms. An exemplary embodiments of this retainer may consist of a retainer for therapeutic treatment that emits certain wavelengths of light into the solution. When a specific light and solution combination is applied to tissues, a synergistic effect may be created that may reduce, and may eliminate microorganisms that cause disease.
- In an exemplary embodiment illustrated in
FIG. 1 , a layer ofantimicrobial solution 102 may be held between thetissue 100 and the retainer fortherapeutic treatment 104. In an exemplary embodiment, one end of a number of fiberoptic cables 103 may be rigidly attached to the retainer fortherapeutic treatment 104 through a number of fiber optic connection interfaces orplugs 101. In a further exemplary embodiment, the second end of the number of fiber optic cables may be rigidly connected to any desired source including, but not limited to, a light emitting diode (LED) and laser. The activation of the antimicrobial solution by a light of a pre-determined wavelength may create a synergistic antimicrobial effect. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone. In an exemplary embodiment, theretainer 104 may includetemperature control elements 106 that warm and further activate theantimicrobial solution layer 102. It may be further appreciated that thetemperature control elements 106 may also cool the antimicrobial solution, or otherwise regulate the temperature of the antimicrobial solution, as desired. In a further exemplary embodiment, a number of antimicrobialsolution delivery elements 114 may be rigidly connected to theretainer 104 fortherapeutic treatment 104 and to a number oftubes 116. - Now referring to exemplary
FIG. 2 , an exemplary embodiment of a retainer for providing therapeutic treatment may be provided. A retainer fortherapeutic treatment 204 may house a number ofheating elements 206 connected to apower supply 210 by apower cable 208. In another exemplary embodiment, a retainer fortherapeutic treatment 204 may house a number oflight terminations 201 that may be connected to alight source 205 byoptic cable 203. In further exemplary embodiment, a retainer fortherapeutic treatment 204 may house an antimicrobialsolution delivery element 214 connected to anantimicrobial solution reservoir 218 though atubing 216. - In an exemplary embodiment, the retainer for
therapeutic treatment 104 may hold solutions in contact withtissues 100, such as flesh or teeth, while thetissues 100 andsolutions 102 may be simultaneously exposed to certain wavelengths of light. The retainer fortherapeutic treatment 104 may include at least one tooth covering tray that may emit light for oral treatmentscreating a synergistic antimicrobial effect between an antimicrobial solution and a light of certain predetermined wavelengths. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone. Theretainer 104 may be installed on an arch of one or more human teeth. A light source may shine from a light emitting device or from the end of a fiber optic cable. The fiber optic cable may have one side exposed down its length. Anantimicrobial solution 102 may fill a dental arch-shaped tray. In an exemplary embodiment, the light source may be blue, or another certain predetermined wavelength of light that may supercharge the solution, with an exposure from, but not limited to, a few second to several minutes, as desired. It may be appreciated that any desired wavelength or exposure time may be applied. - In an exemplary embodiment, an
antimicrobial solution 102 may be used without a reservoir. Theantimicrobial solution 102 may be inserted directly into the body cavity and exposed to light by a fiber optic wand with a number of light emitting fibers. Further exemplary embodiments of a carrier or reservoir may be thesolution 102 itself or a gel. This gel may be inserted in a body cavity with a catheter and exposed to the synergizing light by the same catheter or a different catheter. The synergizing light may create an antimicrobial effect between an antimicrobial solution and a light of certain predetermined wavelengths. The resulting antimicrobial effect may be greater than the effect of an antimicrobial solution or the light acting alone. It may be appreciated that theantimicrobial solution 102 may be delivered by any desired expedient, including, but not limited to, reservoirs, bandages, gels, solutions, head coverings, wraps, socks, stockings, hats, helmets, mitts, suits, tents, probes, and catheters. In another exemplary embodiment the retainer for therapeutic treatment may be a light emitting sponge that can apply and hold the solution on the surface of the tissue. - According to another exemplary embodiment, and generally referring to
FIG. 3 , a full body suit retainer may be provided. A full body suit with tubing may carry a light-enhanced antimicrobial mist or solution to a user wearing the suit. An embodiment of a suit may include a one-piece garment that generally retains air around the user's body. Exemplary embodiments of a full body suit may include a portion that covers at least a user's torso, as desired. Exemplary embodiments may further include portions to cover a user's legs, feet, arms, head, or hands, as desired. Further exemplary embodiments may have collars, cuffs, or elastic portions that may fit against the user to help retain the antimicrobial solution, as desired. The portions may cooperate to provide a garment that may retain the antimicrobial solution within the suit when the suit is worn. A fiber optic cable may wrap around the inside of the suit. A full body suit may include sleeves with gloves or mittens, pants with feet, and a hood with fiber optic cable spaced along the inner fabric of the suit, or otherwise within or on the fabric. - In an exemplary embodiment, gloves, mittens, or feet may help retain the antimicrobial solution within the suit, and may be integrated with the rest of the suit or may be removable. Exemplary embodiments of integrated portions may include fiber optic cable, similar to the rest of the suit. Exemplary embodiments of removable portions may lack fiber optic cable, or may include fiber optic cable that can be connected to the fiber optic cable in the sleeves or pants, as desired. The fiber optic cable may have light terminations spaced along the fiber optic cable inside the suit. The fiber optics may irradiate an antimicrobial solution with a light of certain predetermined wavelengths and may create a synergistic antimicrobial effect. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone. An exemplary embodiment may include a heating element inside the body suit, such heating wires may be embedded in the fabric of the suit.
- In a further exemplary embodiment, the suit may include an input tube or input tubing to carry antimicrobial solution into the suit, an area within the suit to circulate the antimicrobial solution against the user, and an exhaust tube or exhaust tubing to allow air and the antimicrobial solution out of the suit. Exemplary embodiments of tubing may include an input tube on one side of the torso and an output tube on the opposite side, such as input and output tubes on opposite shoulders.
- In an exemplary embodiment, a user may put on the garment, add anti-microbial solution using the input tube, allow the mist to circulate within the suit, and turn on the light source.
- The user may simultaneously input and output antimicrobial solution to circulate through the suit. The user may power on the heating element to warm the mist and/or otherwise activate or control any portion of the suit, as desired.
- Further to the above, another exemplary embodiment of the therapeutic treatment retainer may be illustrated in
FIG. 3 . An embodiment of amedical device 50 may include afull body suit 52 having anintegrated torso portion 54,sleeves 56, pants 58,feet 60, and ahood 62, and removable gloves 64 or mittens 66. Thesleeves 56 may havecuffs 68 to tighten and/or form a seal against the user's wrists. Thehood 62 may haveelastic portions 70 to tighten against the user's face. Further exemplary embodiments may include an input tube 72, such as one located on shoulder of thetorso portion 54, and anexhaust tube 74 on the opposite shoulder of thetorso portion 54. Exemplary embodiments may further include afiber optic cable 76 spaced along the inner fabric of thesuit 52.Fiber optic cable 76 may be coupled to thesuit 52 in any desired fashion. - In further exemplary embodiment, and generally referring to
FIG. 4 , the retainer may be in the shape of a container and may apply an antimicrobial solution that may be enhanced with light of a predetermined wavelength. An exemplary embodiment may include a bowl, such as a round, open-top container that retains an antimicrobial solution. The bowl may be made of generally watertight material so it can retain liquid solution. A fiber optic cable may wrap all around the inside surface of the bowl, with light terminations spaced along the fiber optic cable. The fiber optic cable may have a number of light terminations so that an antimicrobial solution in the bowl is lighted with light from the cable so as to substantially surround an item immersed in the bowl. An exemplary embodiment may include a heating element at the bottom of the bowl. The bowl may have a stand or base, and the heating element may be located in the base, or any other location, as desired. The fiber optic cable may connect through a connection cable to a light source. The light source may have an on/off switch and may have a timer control. Embodiments may include a control box that includes the light and heating power source, such as batteries or a connection to a power outlet. Embodiments of a control box may also include controls for turning the light or heater on or off, setting of timers, and status display. A control box may include receptacles or cables for interfacing with the rest of the retainer, such as a combined interface for both fiber optics and heater power. - In an exemplary embodiment, the antimicrobial solution may be warmed in the bowl. An object or a body part such as fingers may be placed into the antimicrobial solution, and the light source may be turned on. The light source may interact with the antimicrobial solution and may create a synergistic antimicrobial effect. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone. The user may utilize a control box, or any other wired or wireless controller, to turn on or off, or set timers for, the light source, the heater power, or both. It may be appreciated that any desired functions may be managed and timed by the control box.
- As depicted in exemplary
FIG. 4 , an embodiment of amedical device 30 may include abowl 32 with a number offiber optic cables 34 that may wrap around aninside surface 36 of thebowl 32. The number offiber optic cable 34 may have any number oflight terminations 38. Exemplary embodiments may have a base 40, which may contain a number ofheating elements 42. Thefiber optic cable 34 may connect to a number oflight sources 44 through a number of fiberoptic connection cables 46. The number oflight sources 44 may include an off/offswitch 48 or atimer control 49. - In an exemplary embodiment, and referring generally to
FIG. 5 , the retainer may include a catheter that can be inserted into a user's body to dispense antimicrobial fluid. Embodiments may also dispense other medicines or fluids, or may be used in a surgical procedure, as desired. An exemplary embodiment of a catheter may include a light source running into a fiber optic cable, a catheter tube, a mesh to dispense antimicrobial solution, and a termination emitting light. The antimicrobial solution may pass into a first end of the catheter tube, which may be a thin tube or canal down the center of the catheter, made of medical grade materials. An exemplary embodiment may receive medicine or antimicrobial solution in one end of the tube, which may be dispensed out of a mesh near an opposite or distal end of the tube. - Additional exemplary embodiments may include an integrated heating element to warm the antimicrobial solution while in use, or a separate heater to warm the antimicrobial solution before use. An exemplary embodiment may also include a thin fiber optic cable inside the catheter tube, or the catheter tube itself may be made of fiber optic material so that the tube conducts both light and antimicrobial solution. A number of light terminations may be positioned at, or proximate, an end of the tube, near the mesh portion so that the light shines onto the antimicrobial solution when the solution may be dispensed into the user. An exemplary embodiment may include a light emitting cable that may be integrated with the catheter, or a light emitting cable that may be separated from the catheter tube carrying the antimicrobial solution.
- In a further exemplary embodiment, the catheter may be inserted into a body cavity, and may be used for purposes such as drainage or administration of therapeutic materials before or after the device may be used to apply antimicrobial solution. Antimicrobial solution may be preheated with the separate heating element, pumped into the catheter, and dispensed into the user's body. The light may be turned on to supercharge the antimicrobial material while it may be dispensed or immediately after it may be dispensed and the catheter may be left in place until the treatment may be completed. The treatment may create a synergistic antimicrobial effect between an antimicrobial solution and a light of certain predetermined wavelengths. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone.
- In an exemplary embodiment depicted in
FIG. 5 , aretainer 140 may include acatheter 142 having acatheter tube 144, amesh dispenser screen 146, and afiber optic cable 148 having one or more light terminations . Aheating element 152 may be external to thecatheter tube 144, and may provide heatedantimicrobial solution 154 through aninput tube 156. Alight source 158 may be connected through a fiberoptic connection cable 160 to thefiber optic cable 148 with a fiberoptic connection interface 162. - Now referring to exemplary
FIG. 6 , an exemplary embodiment of a hand held light emittingdevice 600 may be provided. The hand held light emittingdevice 600 may include ahandle portion 602 rigidly connected to the first end of aneck 604. The second end of theneck 604 may be rigidly connected to ahead portion 606 housing the light source outlet. In an exemplary embodiment, the light source may be situated in thehandle portion 604 and the light may be guided through the neck by optical element including, but not limited to, fiber optic and mirrors. It may be further appreciated that theneck 604 may be flexible and orientable. The light source may produce a light at a wavelength of about 360 nm to about 600 nm. In an exemplary embodiment, hand held light emittingdevice 600 may be used to irradiate an antimicrobial solution, thus creating a synergistic reaction with an antimicrobial effect greater than the light or the solution acting alone. In an exemplary embodiment, the hand held light emittingdevice 600 may be powered by electric power. Power sources may include, but may not be limited to, batteries, rechargeable batteries, and grid power supply. Thehandle portion 602 may house any necessary elements required to provide the current and intensity required by the light source, such as electrical transformers and electronic components. In a further exemplary embodiment, the hand held light emittingdevice 600 may be powered with batteries and may optionally require thepower supply cable 608. - Acne inflammatory disease results in unsightly lesions, particularly on the face, and in some cases results in severe scarring. An exemplary embodiment of the system, retainer and method of providing therapeutic treatment may decrease the inflammatory disease and the associated scarring by creating a synergistic antimicrobial effect between an antimicrobial solution and a light of certain predetermined wavelengths. The resulting synergistic effect may be greater than the effect of an antimicrobial solution or the light acting alone. In an exemplary embodiment, the system, retainer and method of providing therapeutic treatment generally referred to in
FIGS. 1-6 may provide an improved method for the treatment of acne vulgaris involving the periodic application of an antimicrobial solution containing an effective amount of peroxide agents alone or in combination with one or more of a topical antibiotic, topical anesthetic, nicotinic acid, nicotinamide, antimicrobials, salicylic acid, sulfur, retinoids such as 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid, glycolic acid, tretinoin, borax, and additional chemicals useful in the method. - In other exemplary embodiments, the system, retainer and method of providing therapeutic treatment may utilize blue light, or another certain predetermined wavelength of light that may supercharge the solution, with an exposure from about a few second to a few minutes. In a further exemplary embodiments the antimicrobial solution may be an H2O2 solution, such as a gel, with concentration of 0.3 mM or any concentration of solution that may be suitable as an antimicrobial agent. In an exemplary embodiment, hydrogen peroxide, if used alone may kill 30% of bacteria that may be exposed to it for 20 seconds. Similarly, a 20 seconds irradiation with light of the wavelength from 360 nm to 500 nm may kill 3% of bacteria that may be exposed to it. But then hydrogen peroxide in combination with light of 360 nm to 500 nm may exhibit a synergistic reaction that kills 96% of bacteria exposed to this combination for 20 seconds. This solution may work best at a temperature of about 57 degrees Celsius. It may be appreciated that other chemicals may have different preferred temperatures.
- In an exemplary embodiment, and generally referring to
FIGS. 1-6 , topical solutions, including, but not limited to, hydrogen peroxide, carbamide peroxide, benzoyl peroxide and other chemicals deemed effective may be delivered in various organic vehicles or carriers. Exemplary embodiments of carriers may include a combination of ethyl alcohol and propylene glycol in which the active ingredient may present in the range of from about 0.001% to about 50% by volume of the carrier. The pH of the solution may be adjusted so that tissue sensitivity may be minimized while the effectiveness of the solution may not be hampered. The temperature of the solution may be adjusted to increase or optimize its effectiveness. In an exemplary embodiment, systemic antimicrobial agents may be used to increase the effectiveness of the treatment. The solution may be exposed to light in a wavelength of 360 nm to 600 nm or any other wavelength that proves effective for a certain time that may range from 1 second to 1 minute. - In an additional exemplary embodiment, topical solutions of peroxide compounds may include hydrogen peroxide and/or carbamide peroxide and/or benzoyl peroxide in various organic carriers in concentrations that may range from about 0.001% to about 50% by volume of the carrier.
- In an exemplary embodiment, the antimicrobial solution may be incorporated into various vehicles or carriers including solutions, lotions, creams, gels, mists, pastes and ointments along with one or more of the following ingredients: nicotinic acid or nicotinamide that may be present in concentrations from about 0.001% to 30% by volume of the carrier.
- In an exemplary embodiment, the antimicrobial solution may include erythromycin base in concentrations that may present from about 0.001% to about 30% by volume of the carrier.
- In another exemplary embodiment, the antimicrobial solution may contain clindamycin phosphate methyl 7-chloro-6,7,8-trideoxy-6-(1-5 methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dihydrogen phosphate) with a concentration from about 0.001 to 30% by volume of carrier.
- In another exemplary embodiment, the antimicrobial solution may contain tetracycline hydrochloride in concentrations of from 0.001 to 30% by volume of the carrier; retinoids such as 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid; It may be appreciated that the antimicrobial solution may contain any desired compounds deemed effective in treating acne vulgaris.
- In still other exemplary embodiments, the antimicrobial solution carriers may include combinations of ethyl alcohol and propylene glycol, surface active agents such as lauryl ethers and lauryl esters, and other carriers effective for the desired purposes.
- In other exemplary embodiments, the antimicrobial solution may include a light activated pigment that may fluoresce when exposed to the wavelength of light used in the treatment. This pigment may indicate to the user that the synergistic effect may be occurring.
- Another exemplary embodiment may describe a method of decreasing open and closed comedones and associated inflammation in patients infected with acne vulgaris by topically administering a therapeutically effective amount of peroxide compounds and other therapeutic chemicals that together may form a solution that may be an effective antimicrobial compound for treating acne vulgaris. This solution, once applied, may be exposed to a wavelength of light, for example using embodiments described herein, that may create a synergistic antimicrobial effect that reduces or eliminates bacteria causing acne vulgaris. This synergistic antimicrobial effect may be greater than the solution's antimicrobial effect or the light's antimicrobial effect if they were used separately.
- In one exemplary embodiment, an about 3% solution of hydrogen peroxide in a gel carrier may be prepared. Twice daily topical applications of this solution may be administered to an infected area on a patient suffering from acne vulgaris. After application, the solution may be exposed to light with a wavelength of about 360 nm to about 500 nm for 20 seconds (or some other amount of time) creating a synergistic effect that may be greater than 10 irradiations with the light or 10 applications the antimicrobial solution alone. The light may be applied by a LED device exposing the patient's entire infected area at one time. The solution may be then rinsed off with clean water. After two weeks of treatment, the comedones count on the patient, and the inflamed areas that result from an acne infection may have measurably declined.
- In another exemplary embodiment, a solution of containing chemical species including, but limited to, about 3% hydrogen peroxide, about 3% benzoyl peroxide, and salicylic acid may be combined in a cream form. This solution may be buffered to a pH of about 6. The cream may be applied to areas infected with acne vulgaris on a patient daily. Once the cream is applied, it may be exposed to a 10 watt light source emitting at wavelengths from about 410 nm to about 500 nm thus creating a synergistic effect between the solution and the light causing a greater reduction in microbes than with the light or with the solution acting alone. The retainer may have a number of terminations having a diameter of about 15 mm. This particular size would enable the patient to target small areas. However, it may be appreciates that the diameter of the termination may have any desired value. The exposure time of the light may be about one minute. However, it may be appreciated that any desired duration of treatment may be selected. This exemplary embodiment may be used to maintain an area that once exhibited an active acne vulgaris infection.
- In another exemplary embodiment, a solution containing chemical species including, but not limited to, about 15% carbamide peroxide, about 2.5% clindamycin phosphate (Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dihydrogen phosphate)) and tretinoin may be combined in a gel-form carrier. The carrier gel may be heated to about 40 degrees Celsius. The warmed solution may help to open the patient's pores once it is applied to the infected area. This solution may be applied three times per day. The infected area may be exposed to a light of a wavelength from about 410 nm to about 500 nm by a number of light terminations that would expose an area with a diameter of about 30 centimeters. The infected area and solution may be exposed to this certain wavelength of light for about 30 seconds. The synergistic effect of the light and solution that may be warmed may be greater than the effect of the light or the solution acting individually.
- The foregoing description and accompanying figures illustrate the principles, preferred exemplary embodiments and modes of operation of the invention. However, the invention should not be construed as being limited to the particular exemplary embodiments discussed above. Additional variations of the exemplary embodiments discussed above will be appreciated by those skilled in the art.
- Therefore, the above-described exemplary embodiments should be regarded as illustrative rather than restrictive. Accordingly, it should be appreciated that variations to those exemplary embodiments can be made by those skilled in the art without departing from the scope of the invention as defined by the following claims.
Claims (20)
1. A retainer for therapeutic treatment comprising:
a retainer that retains an antimicrobial solution against tissue;
at least one heating element connected to the retainer for therapeutic treatment;
at least one power supply cable connected to the at least one heating element;
at least one antimicrobial solution delivery element connected to the retainer for therapeutic treatment that delivers an antimicrobial solution;
at least one tube having a first end connected to an antimicrobial solution reservoir and a second end connected to the at least one antimicrobial solution delivery element;
at least one fiber optic cable having a first end connected to a light source; and
at least one light termination rigidly connected to the retainer for therapeutic treatment and connected to the second end of the fiber optic cable.
2. The retainer of claim 1 , wherein the retainer for therapeutic treatment light source includes at least one of a light emitting diode (LED) and a laser.
3. The retainer of claim 2 , further comprising:
a container having an open top and a base beneath the bowl, wherein the fiber optic cable wraps up an inner surface of the bowl, and the fiber optic cable has a number of light terminations so that the antimicrobial solution in the bowl is lighted with light from the optic cable so as to substantially illuminate an item immersed in the bowl from all sides.
4. The retainer of claim 2 , further comprising:
a catheter tube that receives the antimicrobial solution at a first end and a mesh on the catheter tube near a second end opposite the first end, to dispense antimicrobial solution, wherein the light termination is located on the fiber optic cable proximate the mesh.
5. The retainer of claim 2 , further comprising:
a dental tray that retains the antimicrobial solution in a cavity on a side of the tray, wherein the fiber optic cable is retained within the tray, the tissue is a number of teeth of the user, each of the teeth having two opposite sides, and the tray is shaped to hold the lighted antimicrobial solution against the number of teeth; and
a number of light terminations on the fiber optic cable that emit light from the fiber optic cable into the antimicrobial solution, the light terminations being positioned and of sufficient quantity so that there is at least one light termination adjacent to each of the two opposite sides of each tooth.
6. The retainer of claim 2 , wherein the antimicrobial solution is exposed to light of 350 nm to 600 nm for a duration of 1 second to 60 seconds.
7. The retainer of claim 2 , wherein the antimicrobial solution comprises at least one of 3% hydrogen peroxide in a gel carrier.
8. The retainer of claim 2 , wherein the antimicrobial solution comprises at least one of 3% of hydrogen peroxide, 3% benzoyl peroxide, and salicylic acid and the solution is buffered to pH of 6 and irradiated with a 10 watt light source.
9. A method of providing therapeutic treatment, comprising:
coupling a retainer that retains an antimicrobial solution against tissue;
connecting at least one heating element connected to the retainer for therapeutic treatment;
powering the heating element;
connecting at least one antimicrobial solution delivery element connected to the retainer for therapeutic treatment;
connecting at least one piece of tubing having a first end connected to an antimicrobial solution reservoir and a second end connected to the at least one antimicrobial solution element;
providing at least one fiber optic cable having a first end connected to a light source;
connecting at least one light termination rigidly to the retainer for therapeutic treatment and to the second end of the fiber optic cable;
applying the antimicrobial solution on a tissue to be treated;
retaining the antimicrobial solution against the tissue to be treated;
providing a predetermined wavelength of light;
bringing the antimicrobial solution to a predetermined temperature; and
irradiating the antimicrobial solution.
10. The method of claim 9 , further comprising:
exposing the antimicrobial solution to light of 350 nm to 600 nm for a duration of 1 second to 60 seconds.
11. The method of claim 10 , wherein the antimicrobial solution includes 3% hydrogen peroxide in a gel carrier.
12. The method of claim 10 , wherein the antimicrobial solution includes at least one of 15% carbamide peroxide, 2.5% clindamycin phosphate and tretinoin, and the antimicrobial solution is heated to about 40 degrees Celsius.
13. The method of claim 10 , wherein the antimicrobial solution includes at least one of about 3% of hydrogen peroxide, about 3% benzoyl peroxide, and salicylic acid, and further comprising:
buffering the solution to a pH of 6; and
irradiating the solution with a 10 watt light source.
14. The method of claim 10 , wherein the antimicrobial solution includes at least one of 15% carbamide peroxide, 2.5% clindamycin phosphate, and tretinoin and further comprises heating the antimicrobial solution to a temperature of about 57 degrees Celsius and exposing the antimicrobial solution to light of about 400 nm to about 500 nm for about 30 seconds.
15. The method of claim 10 , wherein the antimicrobial solution comprises tetracycline hydrochloride in concentrations of from 0.001 to 30% by volume of the carrier.
16. The method of claim 10 , wherein the antimicrobial solution includes clindamycin phosphate at a concentration from 0.001 to 30% by volume of carrier.
17. The method of claim 10 , further comprising incorporating the antimicrobial solution into one or more carriers.
18. The method of claim 17 , wherein the carriers include at least one of nicotinic acid and nicotinamide present in concentrations from 0.001% to 30% by volume.
19. The method of claim 10 , wherein the antimicrobial solution includes retinoids.
20. The method of claim 19 , wherein the retinoids include 6-[3-(1-adamantyl)-4-methoxy-phenyl]naphthalene-2-carboxylic acid erythromycin base in concentrations from 0.001% to about 30% by volume of the carrier.
Priority Applications (1)
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US14/801,515 US20160015909A1 (en) | 2014-07-18 | 2015-07-16 | System, retainer and method of providing therapeutic treatment for acne |
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US201462026498P | 2014-07-18 | 2014-07-18 | |
US14/801,515 US20160015909A1 (en) | 2014-07-18 | 2015-07-16 | System, retainer and method of providing therapeutic treatment for acne |
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US20160015909A1 true US20160015909A1 (en) | 2016-01-21 |
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US14/801,515 Abandoned US20160015909A1 (en) | 2014-07-18 | 2015-07-16 | System, retainer and method of providing therapeutic treatment for acne |
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US10293148B2 (en) * | 2017-01-06 | 2019-05-21 | Paul Dabney | System, retainer and method of preventing and treating nosocomial infections including methicillin-resistant Staphylococcus aureus infections |
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US10220221B2 (en) * | 2016-12-28 | 2019-03-05 | Olighter Co., Ltd. | Dental device and photodynamic therapeutic system using same |
KR101904357B1 (en) * | 2017-06-12 | 2018-10-05 | 주식회사 크림슨스타 | Infection-resistant denture device |
WO2019139863A1 (en) * | 2018-01-09 | 2019-07-18 | E2Bio Life Sciences, Llc | Method and device for the enhancement of topical treatments for oral mucositis and other oral conditions |
CN109223224A (en) * | 2018-08-13 | 2019-01-18 | 中国医学科学院生物医学工程研究所 | A kind of ultrasonic wave phototherapy facing and application method |
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US20160015494A1 (en) | 2016-01-21 |
US9579177B2 (en) | 2017-02-28 |
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