US2319542A - Therapeutic machine - Google Patents

Therapeutic machine Download PDF

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US2319542A
US2319542A US341990A US34199040A US2319542A US 2319542 A US2319542 A US 2319542A US 341990 A US341990 A US 341990A US 34199040 A US34199040 A US 34199040A US 2319542 A US2319542 A US 2319542A
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cold
applicator
chamber
expansion
expansion chamber
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Franklin E Hall
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M19/00Local anaesthesia; Hypothermia
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25BREFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B15/00Sorption machines, plants or systems, operating continuously, e.g. absorption type
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • F25D3/105Movable containers

Definitions

  • My invention relates to medical apparatuses and more particularly to special types of freezers and cold applicators, which are especially adapted to apply cold to and freeze organs and parts of organs of the human and animal body and has for its object to aid the medical, dental and veterinary profession in the art of anesthetizing, healing, curing of diseases and operating on organs of such bodies.
  • a further object of my invention is to provide an improved arrangement whereby internal organs of the human body, such as, stomach, womb, nose, throat, brain, bladder, rectum, lungs may be reached and may be frozen at any given place for healing or curing it from diseases of infectious or non-infectious origin such as tumors of benign and malignant character.
  • FIG. 1 is a front elevation of a freezing apparatus combination
  • Fig. 2 is a side view
  • Fig. 3 is an enlarged fragmentary sectional detail of applicator for treatment of tonsils
  • Fig. 4 is a view in perspective of acold applicator especially adapted for treatment of teeth
  • Fig. 5 is an enlarged fragmentary sectional view of a cold applicator in shape of a needle
  • Fig. 6 illustrates an embodiment of the present invention with a gastroscope.
  • the frame work of the cold applicator apparatuses is shown as comprising a base I supported on wheels 2 and a top 3 to hold the cold applicator and auxiliary instruments.
  • the electric motor A compressor 5 the condensor 6 and the receiver tank 1 may be of any type used in ordinary small coolingand refrigeration units and need not be described any further.
  • the inlet check valve 8 effects a near even pressure in the distributor 9 from which any desired number of cold applicator instruments may be supplied with refrigerant medium through pressure tight flexible tubings l2 communicatively connected to said distributor by conduit l l.
  • the above mentioned flexible tubings l2 pass through a collecting chamber Ill into pressure tight flexible tubings 2
  • the cold applicator instruments shown in illustrations comprise a high pressure conduit I 3 communicatively connected to intake flexible tubings I 2, through which refrigerant medium is delivered to the expansion chambers l4, l5, l6, ll, 18 and I9 where due to evaporation cold is produced.
  • Said expansion chambers are communicatively attached to return pipes 20, which flexible return 'tubes 2l-, collector I0, and return pipe 22 communicatively connect with the compressor 5 and so complete a closed circuit for the refrigerant medium.
  • the cold applicator instruments are of such sizes, forms and shapes to be suitable for possible approaches and shapes of organs to be treated by cold application.
  • the cold applicator chamber [9 in Fig. 1 is provided with a convex surface symetrically arranged in relation to the center line of the return pipe 29.
  • This type of an instrument is especially adaptable for operations on the skin and body surfaces, while the needle shape of the cold applicator chamber I8 is used for operations on the brain, under the skin, in cavities, etc.
  • the chamber l4 shown in Fig. 2, resembling Hegars cervical dilator, will be preferably used for cold treatment in cavities such as rectum, vagina, womb, etc.
  • Fig. 6 illustrates a novel arrangement of a gastroscope comprising a tubular casing, a telescope 21, an electric light with reflector 28,an air passage tube 3
  • the arrangement of thea'bove' mentioned cold applicator in relation to the optic apparatus is such that after the inflammation or place to be treated in the inflated stomach has'been determined, the stomach will be deflated so that the infected area comes in contact with the cold applicator. From the description of the above embodiment it will be understood, that similar arrangements are workable in combinations of a cold applicator with a cystoscope, bronchoscope, proctoscope and alaryngoscope.
  • Fig. 4 illustrates the form and shape of a cold applicator chamber for teeth and gum treatments, said chamber having two extensions communicatively attached to same.
  • Insulated holders or handles 23, 24 protect the hands of the doctors or physicians operating with said cold applicator instruments.
  • gaseous refrigerant is compressed, condensed and delivered through the high pressure intake tube and tubular conduit to the evaporator chamber where cold is produced for medical treatment.
  • the expanded refrigerant continues to flow through the low pressure return tube to the collector chamber I and to the compressor and so completes a full circulation cycle.
  • the flow capacity of the refrigerant medium is controlled by expansion or check valves and other well known means, which can be set to maintain a near even desired pressure in the di ibuto
  • the expansion or evaporator chambers of the cold applicator instruments are constructed of the best heat and cold conducting materials such as silver, copper, etc., while the high pressure conduits and the return tubes are made of metal or material suitable for their construction and of low heat or cold conducting capacity such as stainless steel, hard rubber, etc.
  • the electrical heater 25 will fit over the conduit tube 20 of the cold applicator instrument, to defrost the outside of expansion chamber by heating the circulating refrigerant medium in the conduit rod, thuspermitting release of the frozen tissue from the cold applicator instrument. Electricity is provided through an electric cord 26 and is controllable by Well known means, and enabling the operator of the apparatus to defrost at will.
  • the expansion chamber is provided with a suitable exhaust pipe 35 and a valve 34 to control the flow capacity of the escaping refrigerant medium.
  • a closed circulation of refrigerant medium is not possible in such an arrangement, without additional equipment.
  • the thermostatic expansion ring 36 is connected through a pressure tube 37 filled with fluctuating liquid to an automatic pressure valve 38 for further control of the flow velocity of the refrigerant medium, by actuation of said pressure valve.
  • Liquid air, carbon dioxide snow, etc., inserted into the cold application chamber through the high pressure conduit l3 will also produce cold in said chamber for topical treatments.
  • a therapeutic apparatus including a cold applicator comprising a hollow member, an expansion chamber therein, an exterior metallic application surface thereon, the wall of the hollow member being bounded on one side by the application surface and on the other side by the expansion chamber, means for introducing expansible fluid to the expansion chamber, at high pressure and suddenly expanding it entirely within the expansion chamber adjacent the application surface and for then discharging the expanded fluid at low pressure from the expansion chamber, and electrically activated means exteriorly disposed with respect to the applicator and independent of the cooling means for heating the applicator to defrost it for ready removal from body cavities.
  • a therapeutic apparatus including a cold applicator comprising a hollow member, an expansion chamber therein, an exterior metallic application surface thereon, the wall of the hollow member being bounded on one side by the application surface and on the other side by the expansion member, and being composed of a material of relatively high thermal conductivity, a supply pipe fixed in position inside of and out of contact with the Walls of the chamber, terminating in a discharge nozzle adjacent the wall forming the application surface, the supply pipe and nozzle being composed of material of relatively low thermal conductivity, means for introducing expansible fluid to th expansion chamber at high pressure and suddenly expanding it entirely within the expansion chamber adjacent the application surface and for then discharging the expanded fluid at low pressure from the expansion chamber, and electrically activated means exteriorly disposed with respect to the applicator and independent of the cooling means for heating the applicator to defrost it for ready removal from body cavities.
  • a therapeutic apparatus including a cold applicator of such size and shape as to be adapted for convenient insertion into body cavities, there being an expansion chamber within the applicator and a metallic application surface outside the applicator and immediately adjacent the expansion chamber, means for introducing an expansible fluid under pressure to the expansion chamber, there discharging and suddenly expanding it entirely within the expansion chamber adjacent the application surface and means for then discharging the expanded fluid at low pressure from the expansion chamber outside of the body cavity into which the applicator has been inserted.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Combustion & Propulsion (AREA)
  • Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Description

May 18,1943 F. E. HALL THERAPEMIC' momma 'med Jim 24. 1940 Patented May 1s, 1.943
UNITED STATES PATENT OFFICE THERAPEUTIC MAOHINE Franklin E. Hall, Chicago, Ill.
Application June 24, 1940, Serial No. 341,990
4 Claims.
My invention relates to medical apparatuses and more particularly to special types of freezers and cold applicators, which are especially adapted to apply cold to and freeze organs and parts of organs of the human and animal body and has for its object to aid the medical, dental and veterinary profession in the art of anesthetizing, healing, curing of diseases and operating on organs of such bodies.
A further object of my invention is to provide an improved arrangement whereby internal organs of the human body, such as, stomach, womb, nose, throat, brain, bladder, rectum, lungs may be reached and may be frozen at any given place for healing or curing it from diseases of infectious or non-infectious origin such as tumors of benign and malignant character.
Other objects and advantages will be seen from the following description of the accompanying drawing in which Fig. 1 is a front elevation of a freezing apparatus combination;
Fig. 2 is a side view;
Fig. 3 is an enlarged fragmentary sectional detail of applicator for treatment of tonsils;
Fig. 4 is a view in perspective of acold applicator especially adapted for treatment of teeth;
Fig. 5 is an enlarged fragmentary sectional view of a cold applicator in shape of a needle;
Fig. 6 illustrates an embodiment of the present invention with a gastroscope.
Similar numerals refer to similar parts throughout the several views.
In the present embodiment as shown in Fig. l and Fig. 2, the frame work of the cold applicator apparatuses is shown as comprising a base I supported on wheels 2 and a top 3 to hold the cold applicator and auxiliary instruments.
The electric motor A compressor 5 the condensor 6 and the receiver tank 1 may be of any type used in ordinary small coolingand refrigeration units and need not be described any further.
The inlet check valve 8 effects a near even pressure in the distributor 9 from which any desired number of cold applicator instruments may be supplied with refrigerant medium through pressure tight flexible tubings l2 communicatively connected to said distributor by conduit l l. The above mentioned flexible tubings l2 pass through a collecting chamber Ill into pressure tight flexible tubings 2| of larger diameter and are contained within said tubings the entire length and extend into and terminate within the expansion chamber of the cold applicator instrument.
The cold applicator instruments shown in illustrations comprise a high pressure conduit I 3 communicatively connected to intake flexible tubings I 2, through which refrigerant medium is delivered to the expansion chambers l4, l5, l6, ll, 18 and I9 where due to evaporation cold is produced. Said expansion chambers are communicatively attached to return pipes 20, which flexible return 'tubes 2l-, collector I0, and return pipe 22 communicatively connect with the compressor 5 and so complete a closed circuit for the refrigerant medium.
The cold applicator instruments are of such sizes, forms and shapes to be suitable for possible approaches and shapes of organs to be treated by cold application.
Referring to the drawing to illustrate some of the forms of the cold applicator chambers it will be seen that the cold applicator chamber [9 in Fig. 1 is provided with a convex surface symetrically arranged in relation to the center line of the return pipe 29. This type of an instrument is especially adaptable for operations on the skin and body surfaces, while the needle shape of the cold applicator chamber I8 is used for operations on the brain, under the skin, in cavities, etc.
The chamber l4 shown in Fig. 2, resembling Hegars cervical dilator, will be preferably used for cold treatment in cavities such as rectum, vagina, womb, etc.
Fig. 6 illustrates a novel arrangement of a gastroscope comprising a tubular casing, a telescope 21, an electric light with reflector 28,an air passage tube 3| and a cold applicator I! for coldtreatments in the stomach. The arrangement of thea'bove' mentioned cold applicator in relation to the optic apparatus is such that after the inflammation or place to be treated in the inflated stomach has'been determined, the stomach will be deflated so that the infected area comes in contact with the cold applicator. From the description of the above embodiment it will be understood, that similar arrangements are workable in combinations of a cold applicator with a cystoscope, bronchoscope, proctoscope and alaryngoscope. The cold applicator instrument presented in Fig. 3 is provided with an arcuate conduit rod 20! and a chamber l5 having a concave surface following up in the same direction as the arc of the conduit rod and is especially adaptable for tonsillar applications, Fig. 4 illustrates the form and shape of a cold applicator chamber for teeth and gum treatments, said chamber having two extensions communicatively attached to same.
Insulated holders or handles 23, 24 protect the hands of the doctors or physicians operating with said cold applicator instruments.
During the operation of the diapexis apparatus gaseous refrigerant is compressed, condensed and delivered through the high pressure intake tube and tubular conduit to the evaporator chamber where cold is produced for medical treatment. The expanded refrigerant continues to flow through the low pressure return tube to the collector chamber I and to the compressor and so completes a full circulation cycle. The flow capacity of the refrigerant medium is controlled by expansion or check valves and other well known means, which can be set to maintain a near even desired pressure in the di ibuto The expansion or evaporator chambers of the cold applicator instruments are constructed of the best heat and cold conducting materials such as silver, copper, etc., while the high pressure conduits and the return tubes are made of metal or material suitable for their construction and of low heat or cold conducting capacity such as stainless steel, hard rubber, etc.
The electrical heater 25 will fit over the conduit tube 20 of the cold applicator instrument, to defrost the outside of expansion chamber by heating the circulating refrigerant medium in the conduit rod, thuspermitting release of the frozen tissue from the cold applicator instrument. Electricity is provided through an electric cord 26 and is controllable by Well known means, and enabling the operator of the apparatus to defrost at will.
In the above described embodiment it was assumed that the refrigerant medium was supplied through a compressor unit. If the cold treatment is of small character and if the apparatus is to be used away from the usual place for operations a lighter and simpler apparatus is desirable. This type of an auxiliary apparatus as shown in Fig. 1 comprises a refill bomb 32 supplying the refrigerant medium' for the cold applicator chamber 19 through a flexible tube 33 and a high pressure conduitv S3. The expansion chamber is provided with a suitable exhaust pipe 35 and a valve 34 to control the flow capacity of the escaping refrigerant medium. A closed circulation of refrigerant medium is not possible in such an arrangement, without additional equipment.
The thermostatic expansion ring 36 is connected through a pressure tube 37 filled with fluctuating liquid to an automatic pressure valve 38 for further control of the flow velocity of the refrigerant medium, by actuation of said pressure valve.
Liquid air, carbon dioxide snow, etc., inserted into the cold application chamber through the high pressure conduit l3 will also produce cold in said chamber for topical treatments.
From the foregoing description itis apparent to those skilled in the medical art, that various changes may be made in my apparatus without departing from the spirit of the invention and,
therefore, I do not limit myself to What is shown in the drawing and described in the specification, but only as indicated in the appended claims.
I claim:
1. A therapeutic apparatus including a cold applicator comprising a hollow member, an expansion chamber therein, an exterior metallic application surface thereon, the wall of the hollow member being bounded on one side by the application surface and on the other side by the expansion chamber, means for introducing expansible fluid to the expansion chamber, at high pressure and suddenly expanding it entirely within the expansion chamber adjacent the application surface and for then discharging the expanded fluid at low pressure from the expansion chamber, and electrically activated means exteriorly disposed with respect to the applicator and independent of the cooling means for heating the applicator to defrost it for ready removal from body cavities.
2. A therapeutic apparatus including a cold applicator comprising a hollow member, an expansion chamber therein, an exterior metallic application surface thereon, the wall of the hollow member being bounded on one side by the application surface and on the other side by the expansion member, and being composed of a material of relatively high thermal conductivity, a supply pipe fixed in position inside of and out of contact with the Walls of the chamber, terminating in a discharge nozzle adjacent the wall forming the application surface, the supply pipe and nozzle being composed of material of relatively low thermal conductivity, means for introducing expansible fluid to th expansion chamber at high pressure and suddenly expanding it entirely within the expansion chamber adjacent the application surface and for then discharging the expanded fluid at low pressure from the expansion chamber, and electrically activated means exteriorly disposed with respect to the applicator and independent of the cooling means for heating the applicator to defrost it for ready removal from body cavities.
3. A therapeutic apparatus including a cold applicator of such size and shape as to be adapted for convenient insertion into body cavities, there being an expansion chamber within the applicator and a metallic application surface outside the applicator and immediately adjacent the expansion chamber, means for introducing an expansible fluid under pressure to the expansion chamber, there discharging and suddenly expanding it entirely within the expansion chamber adjacent the application surface and means for then discharging the expanded fluid at low pressure from the expansion chamber outside of the body cavity into which the applicator has been inserted.
4. The process of applying thermal treatments to body cavities and the like which consists in defining within the cavity a gas tight expansion zone, introducing an expansible fluid into the expansion zone, suddenly expanding the fluid entirely within the zone and then discharging the expanded fluid from the zone and conducting it to a point outside of the body cavity.
FRANKLIN E. HALL.
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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2415455A (en) * 1944-05-06 1947-02-11 Eugene L Barnes Applicator apparatus for refrigeration anaesthesia
DE1064681B (en) * 1955-10-26 1959-09-03 James Dwyer Mcgee Device intended for medical or cosmetic purposes to cool down surfaces of limited size
US3298371A (en) * 1965-02-11 1967-01-17 Arnold S J Lee Freezing probe for the treatment of tissue, especially in neurosurgery
DE1245534B (en) * 1963-11-27 1967-07-27 Westinghouse Electric Corp Surgical probe
DE1278068B (en) * 1963-04-29 1968-09-19 Dr John C Chato Medical probe for cold surgery treatment
DE1466790B1 (en) * 1964-12-18 1971-01-21 Cvi Corp Medical probe for cold surgery treatment
DE1566111B1 (en) * 1967-11-10 1971-09-16 Linde Ag Device for subcooling organic tissue
DE1766906B1 (en) * 1968-08-08 1971-11-11 Leybold Heraeus Gmbh & Co Kg SURGICAL CUTTING INSTRUMENT FOR LOW TEMPERATURE SURGERY
US4111209A (en) * 1977-04-18 1978-09-05 Datascope Corporation Topical hypothermia apparatus and method for treating the human body and the like
US4170998A (en) * 1975-09-26 1979-10-16 Chattanooga Pharmacal Company Portable cooling apparatus
US4292973A (en) * 1977-09-25 1981-10-06 Kabushiki Kaisha Kurio-Medikaru Apparatus for refrigeration treatment
US5062424A (en) * 1991-01-24 1991-11-05 The University Of North Carolina At Chapel Hill Portable apparatus for rapid reduction of elevated body core temperature
US5334181A (en) * 1990-09-26 1994-08-02 Cryomedical Sciences, Inc. Cryosurgical system for destroying tumors by freezing
US5591162A (en) * 1990-07-10 1997-01-07 The Texas A&M University System Treatment method using a micro heat pipe catheter
US6182666B1 (en) 1996-12-26 2001-02-06 Cryogen, Inc. Cryosurgical probe and method for uterine ablation
US6270494B1 (en) 1996-12-26 2001-08-07 Cryogen, Inc. Stretchable cryoprobe sheath
US6530234B1 (en) 1995-10-12 2003-03-11 Cryogen, Inc. Precooling system for Joule-Thomson probe
US20070129714A1 (en) * 2005-05-20 2007-06-07 Echo Healthcare Llc Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (FAT)
US20080154254A1 (en) * 2006-12-21 2008-06-26 Myoscience, Inc. Dermal and Transdermal Cryogenic Microprobe Systems and Methods
US20080183164A1 (en) * 2005-05-20 2008-07-31 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20080200910A1 (en) * 2007-02-16 2008-08-21 Myoscience, Inc. Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling
US20090248001A1 (en) * 2007-11-14 2009-10-01 Myoscience, Inc. Pain management using cryogenic remodeling
US20100274236A1 (en) * 2009-04-23 2010-10-28 Krimsky William S Apparatuses and methods for applying a cryogenic effect to tissue and cutting tissue
US9017318B2 (en) 2012-01-20 2015-04-28 Myoscience, Inc. Cryogenic probe system and method
US9066712B2 (en) 2008-12-22 2015-06-30 Myoscience, Inc. Integrated cryosurgical system with refrigerant and electrical power source
US9155584B2 (en) 2012-01-13 2015-10-13 Myoscience, Inc. Cryogenic probe filtration system
US9241753B2 (en) 2012-01-13 2016-01-26 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US9314290B2 (en) 2012-01-13 2016-04-19 Myoscience, Inc. Cryogenic needle with freeze zone regulation
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9668800B2 (en) 2013-03-15 2017-06-06 Myoscience, Inc. Methods and systems for treatment of spasticity
US10130409B2 (en) 2013-11-05 2018-11-20 Myoscience, Inc. Secure cryosurgical treatment system
US10888366B2 (en) 2013-03-15 2021-01-12 Pacira Cryotech, Inc. Cryogenic blunt dissection methods and devices
US11134998B2 (en) 2017-11-15 2021-10-05 Pacira Cryotech, Inc. Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods
US11311327B2 (en) 2016-05-13 2022-04-26 Pacira Cryotech, Inc. Methods and systems for locating and treating nerves with cold therapy
US11633224B2 (en) 2020-02-10 2023-04-25 Icecure Medical Ltd. Cryogen pump

Cited By (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2415455A (en) * 1944-05-06 1947-02-11 Eugene L Barnes Applicator apparatus for refrigeration anaesthesia
DE1064681B (en) * 1955-10-26 1959-09-03 James Dwyer Mcgee Device intended for medical or cosmetic purposes to cool down surfaces of limited size
DE1278068B (en) * 1963-04-29 1968-09-19 Dr John C Chato Medical probe for cold surgery treatment
DE1245534B (en) * 1963-11-27 1967-07-27 Westinghouse Electric Corp Surgical probe
DE1466790B1 (en) * 1964-12-18 1971-01-21 Cvi Corp Medical probe for cold surgery treatment
US3298371A (en) * 1965-02-11 1967-01-17 Arnold S J Lee Freezing probe for the treatment of tissue, especially in neurosurgery
DE1566111B1 (en) * 1967-11-10 1971-09-16 Linde Ag Device for subcooling organic tissue
DE1766906B1 (en) * 1968-08-08 1971-11-11 Leybold Heraeus Gmbh & Co Kg SURGICAL CUTTING INSTRUMENT FOR LOW TEMPERATURE SURGERY
US4170998A (en) * 1975-09-26 1979-10-16 Chattanooga Pharmacal Company Portable cooling apparatus
US4111209A (en) * 1977-04-18 1978-09-05 Datascope Corporation Topical hypothermia apparatus and method for treating the human body and the like
US4292973A (en) * 1977-09-25 1981-10-06 Kabushiki Kaisha Kurio-Medikaru Apparatus for refrigeration treatment
US4348873A (en) * 1977-09-25 1982-09-14 Kabushiki Kaisha Kurio-Medikaru Apparatus for refrigeration treatment
US4412538A (en) * 1977-09-25 1983-11-01 Kabushiki Kaisha Kurio-Medikaru Apparatus for refrigeration treatment
US5591162A (en) * 1990-07-10 1997-01-07 The Texas A&M University System Treatment method using a micro heat pipe catheter
US5334181A (en) * 1990-09-26 1994-08-02 Cryomedical Sciences, Inc. Cryosurgical system for destroying tumors by freezing
US5674218A (en) * 1990-09-26 1997-10-07 Cryomedical Sciences, Inc. Cryosurgical instrument and system and method of cryosurgery
US5062424A (en) * 1991-01-24 1991-11-05 The University Of North Carolina At Chapel Hill Portable apparatus for rapid reduction of elevated body core temperature
US6530234B1 (en) 1995-10-12 2003-03-11 Cryogen, Inc. Precooling system for Joule-Thomson probe
US6451012B2 (en) 1996-12-26 2002-09-17 Cryogen, Inc. Cryosurgical method for endometrial ablation
US6270494B1 (en) 1996-12-26 2001-08-07 Cryogen, Inc. Stretchable cryoprobe sheath
US6182666B1 (en) 1996-12-26 2001-02-06 Cryogen, Inc. Cryosurgical probe and method for uterine ablation
US6475212B2 (en) 1996-12-26 2002-11-05 Cryogen, Inc. Cryosurgical probe with sheath
US6193644B1 (en) 1996-12-26 2001-02-27 Cryogen, Inc. Cryosurgical probe with sheath
US11350979B2 (en) 2005-05-20 2022-06-07 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7850683B2 (en) 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20080183164A1 (en) * 2005-05-20 2008-07-31 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US9072498B2 (en) 2005-05-20 2015-07-07 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20090171334A1 (en) * 2005-05-20 2009-07-02 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US11963706B2 (en) 2005-05-20 2024-04-23 Pacira Cryotech, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
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