US2483825A - Syringe and ampoule combination and ampoule - Google Patents

Description

Oct. 4, 1949. s. D. GOLDBERG 2,483,825

SYRINGE AND AMPOULE COMBINATION AND AMPOULE Filed Aug. 12,. 1946 2 Sheets-Sheet l 50/22112/ D. 0/0%Pr9 INVENTOR. BY z bm ATTORNEY Oct. 4, 1949 s. D. GOLDBERG SYRI NGE AND AMPOULE COMBINATION AND AMPOULE ZSheets-Sheet 2 Filed Aug. 12, 1946 Jamae/ Z go/o fiery INVENTOR.

BY ATTORNEY Patented Oct. 4, 1949 UNITED" STATES PATENT OFFlCE SYRING'E AND AMPOULE COMBINATION AND AMPOULE Samuel D. Goldberg,.Jamaica, N. Y.

Application August 12, 1946', Serial No. 689,913

11 Claims. I

My invention relates to syringes and reservoirs therefor-suitable for containing and ejecting fluid through a cannula or needle and more particularly to a combination instrument comprised of an ejecting means,'reservoir and cannula.

Heretofore most injecting instruments have been formed of a syringe frame, aseparate cartridge or ampule containing the medicament to be injected, and. a needle. To combine these elements into an injecting instrument ready for use, it was necessary to sterilize the frame and needle and assemble them together, and then sterilize. the. ampule head and insert the ampule into the frame. Other instruments have been formed" with asterilizing case to. hold the instrument elements but these required that that elements be assembled and the ampule or cartridge inserted;

The. assembling and sterilizing of the instrument elements required time, and their exposure during this time, which was after sterilization, permitted them to become contaminated. In addition, the sterilization given to the rubber and other resilient. cover of the ample was never perf'ect as it consisted ofa hasty washing with alcohol. or a. short flashing with fire, alcohol not killing all germs and a. too long flashing burning or melting. the rubber and charring its surface.

It is therefore an object of the invention to form. a complete assembled, sterile, one-shot syringe, which is always ready and available for use without sterilization or assembly.

The needle. holding. meansheretofore in. use has been of two types, one, where the needle is kept separate, and positioned onthe syringe when the syringe. is. about to be used, and the other where the needle. is built into the framework of the syringe. The first. type required a complicated and costly end on theneedle. and a corresponding end piece in the syringe: Thesecond type re.- quires the steel framework of the syringe, to be enlarged and. lengthened to. provide a grip. tor the frame about the needle above and below the flange.

.An object ofthe inventionis to: form. the syringe reservoir itself with extending elements. which hold the. needle, thus-eliminating the frame work, with-.its-extended needle holding means, butusing a. simple flanged needle and holding. it. between elements of the reservoir barrel and itsclosure.

The. syringes-muse, at present, arev formed suitable for usew-ith theordinary quick flowing fluids of low viscosityandso. have been. designed with. a. small: orifice at the. filling end The present. syringe is designed for use especially with high viscosity material of a wax or oil base and so differs from the former syringe reservoirs in the method of closure, filling and size of orifice to permit rapid filling and closure of the reservoir.

Syringes heretofore in use have been made of steel .or like metal and their ampules of glass. This is an expensive procedure and the question of sterilizationis always present.

It is an object of this invention therefore to form a combination syringe and ampule into a single unit of a plasticor other-like substance with a cannula which will be retained sterile and covered from the moment of the filling of the ampule till the time of use; particular attention being paid to the shape; position and form of the elements and the methods of their joinder to permit their being cast from simple and inexpensive molds, toinsure a perfect sealing of the medicament in its reservoir, to provide a secure means of holding the needle, and to result in a well built, sturdy over all structure.

Another" object isto form a simple, inexpensive ampule with a plunger means attached.

Some of these and other objects are accomplished by forming my single shot combination syringe and ampule unit'of a barrel with a partial closure at one end and a slidably positioned plunger means at the other end, a resilient puncturable disk being seated over the partial closure, a disk retaining element engaging the barrel and retaining the disk sealing the partial closure, a cap having an outwardly extending conical projjection, and engaging either the retaining element or the. barrel and the retaining element, its projection and the cap having aligned passageways, axial of. each element, a cannula or needle extending in the passageways with its flange between the cap and-retaining element and one of its ends adjacent the disk to be punctured, and a sheath or cover being fitted to the conical projection and covering the exposed end of the needle.

Other of these. objects are accomplished by forming an ampule of a barrel with a partial closure in the vicinity of one of its ends and a plunger means atthe other end, covering the partial closure with a disk and holding it in a sealing condition by a. retaining element secured to the. barrel, the retaining element having a longitudinally extending passageway whereby a needle end can be inserted through the disk into the barrel.

For further comprehension of the invention, and of the objects and advantages thereof, reference will be had to the following description and 2,483,825 ii Li f. If}

g the accompanying drawings and to the appended claims in which the various novel features of the invention are more particularly set forth.

In the accompanying drawings forming a material part of this disclosure:

Fig. 1 is a perspective view of a single shot sterile syringe with an integrally contained reservoir and a cap shown detached, embodying the invention.

Fig. 2 is a longitudinal axial section through the syringe shown in Fig. 1.

Fig. 3 is a longitudinal, axial section through a syringe showing a variation of the invention.

Fig. 4 is a perspective detail showing the sheath and needle end of the syringe of Fig. 3.

Fig. 5 is a fragmentary longitudinal axial section through a syringe showing a further variation of the invention.

Fig. 6 is a perspective detail showing the sheath and needle end of the syringe of Fig. 5.

In the drawings and in this specification, in which like reference numbers designate similar parts, a syringe 59, shown in Figs. 1 and 2 and constructed in accordance with the invention herein, is comprised of an elongated barrel H,

suitable for containing a hypodermic solution, a

plunger means l2 positioned at one end of the barrel, a seal or disk iii, a disk-retaining element I4, a cap l5 positioned at the other end of the barrel, a cannula i6, extending through and adjustaoly positioned for use by the cap, and a sheath 11, covering and protecting an exposed end of the cannula.

The barrel II is cylindrically shaped and is provided, in the vicinity of but not at its needle bearing end, with an inwardly extending fiange l8, which forms a partial closure for the barrel, and acts as a recessed seat for the disc $3. The barrel wall, adjacent the seat, is provided on its inner face with female thread 19, and its outer face with male threads 2 The other end of the barrel is provided with extending arms 2|, forming finger grips.

The plunger means 12 is formed with a piston 22, a piston head 23, threaded to one end of the piston, to permit forward and retracting movement thereof, and hand grips 24, extending laterally from the other end of the piston. The piston head, which is slidably positioned within the barrel is provided with concentric grooves 25, filled with lubricant to cause smooth action within the barrel.

The disk It, which is seated on the flange l8 of the barrel, is formed of rubber, neoprene or a like resilient pierceable material suitable for being punctured by a hypodermic needle.

The disk retaining element [4 is structurally formed like a pipe nipple, with end faces 25, a hole 21, and external threads 28, and is positioned with its hole co-axial with the opening of the seat and barrel and with one of its end faces holding the disk I3 securely against the flange seat iii to seal the hypodermic within the barrel, while its threads 28 coact with the barrel threads I9.

The cap I5 is formed with a top 29, sides 3i extending laterally from the rim of the top, and with a conical axially located projection extending laterally from the top and oppositely to the sides. The top and the projection of the cap are provided with an axial hole, opening or passageway 32, and the inside face of the sides 38 of the cap with threads 33. The cap is retained over the ends of the barrel, removed from the plunger means, by the engagement of its threads 33 with the threads 28, of the barrel.

The cannula IE5, which is a common hypodermic needle formed with a tube 34 and a ball or flange 35 extending about the tube, intermediate its ends is positioned, until the syringe is about to be used, with one of its ends extending in the bore 21 of the disk retaining element, adjacent the disk l3 and its other end extending through the passageway 32 of the cap and its ball 35 between the outer end face 26 of the retaining element and the inside of the top 29 of the cap and when the syringe is about to be used, the cap is tightened on to the barrel, advancing the end of the cannula within the retaining element through the disk into the hypodermic. The bore of the retaining element and the passageway 32 of the cap are large enough to permit the cannula tube to slide easily, but are small enough so that together with the gripping action of the top and end of the retaining element on the ball, when the cap is advanced on the barrel, they hold the cannular firmly during an injection.

The sheath I! is formed with a conical portion 38 and a tube portion 31 and is positioned with its conical portion fitting snugly over and gripping the projection 3| of the cap and its tube containing, protecting and holding sterile the end of the hypodermic needle which is suited for piercing the body.

The above described elements, except the disk l3 of the syringe H can be inexpensively and easily formed of plastic, glass or the like as they are all of a simple form, well adapted to be cast.

Omitting the precautions that must be taken with surgical instruments of this kind to make and keep them sterile, the hypodermic filled sterile syringe is quickly andeasily produced from the elements in the following manner: assembling the plunger means and inserting it into the open end of the barrel, filling the barrel with the hypodermic solution through partial closure l8, positioning the disk, screwing the disk retaining element tightly against the disk, screwing the cap partially on to the barrel with the cannular prepositioned with its ball between the cap top and retaining element end, and finally forcing the sheath on to the projection of the cap.

The syringe, as produced, is prepared for use by tightening the cap onto the barrel until the cannula end within the disk retaining element it is advanced to and through the disk and into the hypodermic and the sheath is removed from the cap projection.

The medicament carried by the syringe now can be ejected by pressing the hand grips of the piston toward the finger grips of the barrel thus advancing the piston head towards the disk l3 and forcing the fluid through the tube'of the cannula.

The form of construction and the shape of the elements above disclosed is particularly well suited for use with wax based and heavy oil hypodermics of a high viscosity as the relatively large size of the opening in the partial closure permits a quick and simple filling of the barrel of the syringe with the hypodermic.

Variations of the invention which follow all embody the basic principle of forming a single shot syringe with a wide mouthed partial closure, sealed by a disk, held by a retaining element and screwing or otherwiseadvancing a cap to force a cannula end through the disk and providing a sheath to cover the exposed needle end.

A syringe variation 38, shown in Figs. 3 and 4, is comprised of a barrel 39, a plunger means 40, a seal or disk 41, a disk retaining element 42, a cap 43, a cannula 44 and a sheath 45. The

plunger meansm, the cannula thesheath am; to the plunger means. 112; cannula Hi andithesheathi 1515,. respectively;

- The '33: formed with an axially positinned. partial closure. oneaend exterior threadings 4.1 and 458: at. its partial closure and other: endsrespectinely- A finger grip bar d9. provided. with a. threadedaholeiin is positioned on. the barrel; about its tlneaded; portion 4'8;

Theseal or disk-41 whichis formed: of, material td the disk I 3,,is; positioned adjacent the partial closure 4-6 and outside the barrel.

The disk retaining. element. 42 is formedsimilar to a. cylindrical cap with a closure 51% and sides5r2 extend-ing therefrom.

, The outerfaceof the sidesadjacent. the closure is-provided with threads 5% and the inner faceof the sides with threads 54. The closure is provided with an axially disposed hole 55 extending therethrough. The disk retaining element is positioned about an; end of the barrel with its threads 54 engaging the threads 41 of they barrel and itsclosure restingagainstand sealing the disk to the. partial closure of the. barrel preventing the hypodermic from. escaping.

The cap 43 is formed with a cover 56 andsides 51 extending therefrom, the sides being provided with female threads 58', the cover with an axially aligned conical projection 59 extending oppositely to the sides and the cover and: projection having an axially aligned hole 60-. The cap is positioned about the disk retaining element with its threads 58 engaging the threads 5?,- of element.

The cannula 44 is positioned with its tube extending in the holes 55' ofthe element 32- at $3 of the-capand with its fiangebetween the outside face of the closure 5i of the element and the cover 56. of the cap. The normal position of the cannula, when itis: not ready for use, is with oneof its. ends in the vicinity of the disk 4.1. syringe is prepared; for use by tightening the cap on; retaining element. and so advancing the needle until its end, inv the retaining element, pierces thediskand enters the hypodermic in the barrel.

The conical portion of the sheath 4.5 fits, over the conical projection of the cap t3 and encases. andprotectsthe exposed end of the cannula.

A. syringe Bl, containing another variation of.

the invention and shown in part in Figs. 5 and 6. 1

The

is comprised of. a barrel 62,, disk 63, a disk retain.

ing element 64, a cap 65, a cannula. 6.6 and a. sheath 61.,

The barrel 52 as shown, the, cannula 6B and the sheath 6! are similar to and similarly. positioned to their corresponding, parts in the syringe iii and the disk retaining. element '64 is shaped similariy to the element i4.

The element 64 is positioned partl in the barrel. and partly extending therefrom.

The. cap 65. is formed with, acover 68 and sides GiLIthe sides being provided with female threads Hi and the cover with projection TI and, hole. 12"

Hesdlerisxasterileprotectfidcomplete. How ever, the; barrel with its disk and: disk element together form a complete ampuleanduas such is a marketable. pno'dunt by itself, either with or without'the plunger means.

Whilel have: and described the. preferred embodiments. of: my invention, it is. to. be understood that Ida not limit myself tovtheprecis constructions. disclosed and the right is reserved to all changes modifications. com- 7 ing; within the. scope of; the. invention as defined many or all of thezappended claims;

Having thus: described my invention, what I cleimasnew desire-to :sccureby United States Letters Patent, is :1

1;, A. syringe. comprising a barrel member having a reservoir suitable tor containing; fluid medicament, apuncturable disk, a disk-retaining member, a needle, vacap for advancing. the needle to puncture thedi'sk, and: means to exert pres sureon and forcibly eject the medicament from the reservoir, the barrel. member slidably carry ing the pressure meams at one end and a partial closure positionedin the vicinity'of the other end forming a recess, the disk being disposed the recess sealingthe partial closure, the disk-retaining member having are opening therethrough and extending within the recessand holdingthe disk in sealing position, the caphaving a cover portion with an opening therethrough and sides engaging one of the members, the. needle extending through the: openings with one of its ends adjacent the disk and its other end projecting outwardlyfrom the opening in the cap-,. and the pressure means having a piston slid'ably disposed in thebarrel reservoirand a plunger extending outwardlythe piston.

2. A syringecomprising a barrel member having a reservoir suitable for containing fluid medicament, a puncturable disk, a disk-retaining member, a needle, a cap for advancing the needle to puncture the disk, and means to exert pressure on and forcibly eject the medicament from the reservoir, the barrel member slidably carrying the pressure means at one end and a partial closure positioned in the vicinity of the: other and forming a recess, the disk being. disposed. in the recess sealing the partial closure, the disk-retaining. member having an opening therethrough and ex' tending threadably within the recess and. holding.

the disk. firmly in sealing position, the cap having acover portion with anopening therethrough and threaded sides engaging one of the members, the needle extending through the openings with one of, its ends; adjacent the disk and. its other end projectingoutwardly from theopening in the cap, and the pressure: means having a piston slidably disposed in the barrel reservoir and a plunger extending. outwardiy from thepiston.

3. A syringev comprising a barrel having a reservoir for fluid medicament, a puncturabledisk, av cylindrical member with external threads and an axial hole, a cap having a covering portion and sides laterally extending therefrom with femalethreads thereon, and the covering portion having an opening therethrough, a needle capable of puncturing the disk, .and means to-exert pressure on the medicament including a piston and aplunger, the barrel having the pressure means. inone end and a partial closure set somewhat. inwardly from. the other and forming a recess, the disk being disposed in the recess. sealing the. partial closure,.the cylindrical. member being dis posed partly in. the recess and retaining the disk securely in sealing. position, part of the threaded:

portion of the cylindrical member extending outwardly from the recessedend of the barrel and engaging the female threads in the cap, the needle extending partly in the hole in the cylindrical member and throughthe cap with its perforating end adjacent the disk and its other end projecting outwardly from the opening in the cap flange, the piston being slidably disposed in the barrel reservoir, and the plunger extending outwardly from the piston.

4. A syringe comprising a barrel having a reservoir for fluid medicament, a puncturable disk, a cylindrical member with external threads and an axial hole, a cap having a covering portion and sides laterally extending therefrom with female threads thereon, and the covering portion having an opening therethrough, a needle capable of puncturing the disk, and means to exert pressure on the medicament including a piston and a plunger, the barrel having the pressure means in one end and a partial closure set somewhat inwardly from the other end forming a recess, said recess having female threads, the disk being disposed in the recess sealing the partial closure, the cylindrical member being disposed partly in the recess with some of its external threads engaging the female threads of the barrel recess and holding the disk tightly in sealing position, the threaded portion of the cylindrical member projecting outwardly from the recessed end of the barrel being engaged with the female threads in the cap, the needle extending partly in the hole in the cylindrical member and through the cap with its perforating end adjacent the disk and its other end projecting outwardly from the opening in the cap flange, the piston being slidably disposed in the barrel reservoir, and the plunger extending outwardly from the piston.

5. A syringe comprising a barrel having a reservoir for fluid medicament, a puncturable disk, a threaded cylindrical piece and an axial hole, a cap having a covering piece and laterally extending sides, the covering piece having an opening therethrough and the sides having female threads, a needle having an end capable of puncturing the disk, and means to exert pressure on the medicament, the barrel having the pressure means in one end and a partial closure set somewhat inwardly from theother end forming a recess, said recessed barrel end being provided with male and female threads, the disk being disposed in the recess sealing the partial closure, the cylindrical piece being disposed in the recess with its outside threads engaging the female threads in the barrel recess retaining the disk firmly in sealing position, the cap extending about the recessed end of the barrel with its female threads in engagement with the barrel male threads, the needle extending partly in the hole in the cylindrical piece and through the cap with its perforating end adjacent the disk and its other end projecting outwardly from the opening in the cap cover, and the pressure means including a piston slidably disposed in the barrel reservoir and a plunger extending outwardly from the piston.

6. A syringe comprising a barrel having a reservoir for fluid medicament, a puncturable disk, a threaded cylindrical piece and an axial hole, a cap having a covering piece and laterally extending sides, the covering piece having an opening therethrough and the sides having female threads, a needlehaving an end capable of puncturing the disk and an enlarged portion intermediate its ends, 'and'means to exert pressure on the medicament, the barrel having the pressure means in one end and a partial closure set somewhat inwardly from the other end forming a recess, said recessed barrel end being provided with male and female threads, the disk being disposed in the recess sealing the partial closure, the cylindrical piece bein disposed in the recess with its outside threads engaging the female threads in the barrel recess retaining the disk firmly in sealing position, the cap extending about the recessed end of the barrel with its female threads in engagement with the barrel male threads, the needle extending partly in the hole in the cylindrical piece and through the cap with its perforating end adjacent the disk and its other end projecting outwardly from the opening in the cap cover, the enlarged needle portion being positioned between the cap and the cylindrical piece, and the pressure means including a piston slidably disposed in the barrel reservoir and a plunger extending outwardly from the piston.

7. A syringe comprising a barrel having a reservoir for fluid medicament, a puncturable disk, a disk-retaining member with male threads and an axial hole, a cap having a covering piece an laterally extending sides with female threading, the coverin piece having an opening there through, a needle having an end capable of puncturing the disk, and means to exert pressure on the medicament, the barrel having the pressure means in one end and a partial closure in the vicinity of the other end forming a recess, said recessed barrel end being provided with female threads, the disk being disposed in the re-, cess sealing the partial closure, the disk-retaining member being disposed with one end within the recess and some of its male threads engaging the female threads in the barrel recess retaining the disk firmly in sealing position, the cap extending about the other end of the disk-retaining member with the cap female threads engaging others of the male threads of the disk-retaining member, the needle extending in the hole in the disk-retaining member and through the cap withits perforating end adjacent the disk and its other end projecting outwardly through the opening in the cap cover, and the pressure means including a piston slidably disposed in the barrel reservoir and a plunger extending outwardly from the piston.

8. A syringe comprising a barrel having a reservoir for fluid medicament, a puncturable disk, at disk-retaining member, a needle having an end capable of puncturing the disk, ,a' sheath, a cap for advancing the needle to puncture the disk, and means to exert pressure on the medicament, the barrel having the pressure means in one end, a partial closure at its other end, and male threads at said partially closed end, the disk covering the partial closure and sealing it, the diskretaining member having a bottom with an opening therethrough, sides with female threads en-' gaging the barrel male threads to retain the disk in sealing position and male threads about its bottom closure, the cap having a cover portion with an opening therethrough and sides with female threads in engagement with the male threads of the disk-retaining member, thesheath removably engaged to the cap, the needle extending in the openings with its perforating end adjacent the disk and its other end projecting outwardly from the cap and into sheath, and the pressure means having a piston slidably disposed in the barrel reservoir and a plunger extending outwardly from the piston.

9. An ampule, suitable for use in a syringe, comprising a tube, a closure means, a puncturable disc and a disc retaining member, said tube in the vicinity of one .of its ends bearing the closure means and at its other end provided with a recessed seat bearing the puncturable disc, said discs retaining memberand the tube end in the vicinity of the seat having co-acting threading means for advancing the disc retaining member toward the seat and imprisoning the disc thereagainst.

10. An ampule, suitable for use in a syringe, comprising a tube, a closure means, a puncturable disc, and a disc retaining member, said tube bearing the closure means at one end and having an inturned rib in the vicinity of, but not at, its other end, said disc retaining member and tube end adjacent the rib having coacting threading means for advancing the member on the tube and retaining the puncturable disc on the rib.

11. An ampule, suitable for use in a syringe, comprising a tube, a closure means, a punctur- REFERENCES CITED The following references are of record in the file of this patent:

UNITED STATES PATENTS Number Name Date 1,961,490 Hein June 5, 1934 20 2,102,704 Hein Dec. 21, 1937 FOREIGN PATENTS Number Country Date 639,855 Germany Dec 14, 1936

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