US2554451A - Hypodermic syringe - Google Patents

Hypodermic syringe Download PDF

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Publication number
US2554451A
US2554451A US697298A US69729846A US2554451A US 2554451 A US2554451 A US 2554451A US 697298 A US697298 A US 697298A US 69729846 A US69729846 A US 69729846A US 2554451 A US2554451 A US 2554451A
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Prior art keywords
seal
barrel
abutment
ampoule
movement
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US697298A
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Aaron W Barry
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M2005/3206—Needle or needle hub disconnecting devices forming part of or being attached to the hub or syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Definitions

  • the present invention relates to a hypodermic syringe and more particularly to a hypodermic syringe of the type adapted to receive an ampoule having a seal received in one end and capableloil piston-like movement therein.
  • hypodermic syringe of the character described' to provide means for predetermining dosage admin- ⁇ istered in fractions or multiples thereof of they contents of the syringe.
  • Figure 3 is a longitudinal view partly in sectiony of yet another embodiment of the improved hypodermic syringe.
  • FIG 4 is a longitudinal view partly in section of a fourth embodiment of the present invention.
  • the hypodermic syringe comprises a barrel lil having a generally cylindrical body portion open at one vendand having its opposite end closed by an end wall 2 which is provided with a central, preferably non circular opening I3 therein.
  • the open end of the barrel I is provided with a pair of lateral projections I4 which serve as nger pieces during use of the syringe, as will subsequently be described.
  • the syringe is intended for use with an ampoule 20, which is illustrated as comprising an elon-V gated, generally cylindrical body formed of gl'a'ss and open at both ends.
  • is provided and the material to be administered is contained within the chambers 22 located withinv the ampoule outwardly from the central partition 2
  • Each end of the ampoule 2t is provided with a seal 23 which is formed of a material easily penetrated by the end of a hollow needle but which is adapted to sealingly engage the needle after penetration. Certain rubber compositions are suitable for the seals and these are well known in the art.
  • the seals 23 are adapted to have a piston-like sliding movement within the interior of the ampoule, for a purpose which will subsequently be described.
  • a separate removable cap 25 is provided which :its over the outer end'4 of the ampoule 2li and cooperates with the finger pieces I4 previously described so that pressure l
  • Other objects and features of the. invention may be applied therebetween to force the ampoule downwardly toward the closed end of the barrel.
  • a seal stop 39 Adjustably received within the central opening in the end wall E2 of the barrel is a seal stop 39 of the same cross sectional shape as the central opening i3 and which is slidably mounted therein.
  • a double-ended needle 35 is provided which in use is supported against movement relative to the barrel and the needle 35 has an inner portion/3,6 which extends inwardly of the barrel beyond the end of the seal stop 3@ and is adapted to penetrate the seal 23 as the ampoule 20 is moved to the right, as seen in this figure.
  • the outer portion 31 of the needle extends outwardly beyond the end of the assembly and is the portion thereof which is adapted to penetrate the skin of a patient.
  • the needle 35 is a unitary, integral, hol1ow,'metallic tube which is rigidly and' permanently secured to the seal abutment til.
  • the'seal abutment 3B at its inner end is of tubularconstruction having a central opening 38 through which the inner portion 36 of the needle extends.
  • the end 39 of the seal abutment is adapted to engage the seal 23 after the inner portion 36 of' the needle has penetrated the seal 23.
  • Further movement of the ampoule 2B to the right, as seen in Figure l, will result in a relative sliding movement of the piston-like seal 23 to the left, thus applying pressure to the liquid contained within the chamber 22 oi the ampoule, which in turn forces it outwardly through the needle 35. It will be apparent from an inspection of this ligure that the dosage administered by full movement of the ampoule into the barrel Ill, which movementis limited by the engagement of the end of ⁇ the Ya male Luer tting iii.
  • reza-isi is a predetermined fraction or multiple thereof of the contents of the chamber 22 when lled. It will further be observed that employing the double-ended ampoule illustratedY in Figure 1; after the material at one end o f the ampoule is exhausted the ampoule may be reversed in the barrel and the material in the other end thereof administered in like manner.
  • the modification illustrated in Figure 2 is essentially similar to that illustrated in Figure l and onlythe feature of difference will be described.
  • the tube abutment illustrated at 40 has its outer portion formed as The outer portion l2 of the needle is provided with a conventional female Luer type tting 43. This construction permits replacement of the outer portion of the needle as the same becomes dulled or otherwise unsuitable for continued use. IThe inner portion l of the double-ended needle in this modication is permanently secured to the tube abutment 4B.
  • FIG. 4 yetl yanother embodiment of the invention is illustrated in which the seal stop G is provided with threads at its outer end as indicated at 6 I.
  • a cooperatingly threaded tting 52 is provided which screws over the thread 5
  • the tting E2 carries the double-ended needle, having an outer portion 63 and an inner portion E4.
  • the double-ended needle is a single integral needle of the type illustrated in Figure l, but may be replaced in the tube stop G, as is plainly apparent from Figure 4.
  • a hypodermic syringe adapted to employ an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, said syringe comprising a barrel open at one end to receive the end of the ampoule having the penetrable seal therein, a hollow doubledended needle at the othery end of said barrel, a seal-engaging abutment at said other end o the barrel, an ampoule-engaging abutment at said other end of the barrel, means mounting one of said abutments for movement longitudinally of said barrel relative to the other abutment, and rigid step-by-step positioning means for retaining said movable abutment rigidly in a selected one of a plurality of positions of adjustment rel-A ative to the other abutment to predetermine the dosage subsequently administered by movement of said ampoule into said barrel against its abutment.
  • said positioning means includes selectively engageable step-by-step positioning elements carried by said barrel and the movable abutment and effective to so position said abutments as to administer predetermined fractions or multiples thereof of the contents of said ampoule in successive injections.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, said barrel being closed at the other end to provide a stop for theinward movement of said ampoule into said barrel, a seal abutment located in the other end of said barrel and adjustable therein to predetermine the dosage injected by movement of said ampoule fully into said barrel, a doubleended needle carried at said other end of said barrel, said needle having a portion extending into said barrel beyond said seal abutment to penetrate said seal prior to its piston-like movement resulting from movement of said ampoule after engagement of said seal abutment by said seal and step-by-step positioning means between said barrel and said seal abutment, said means comprising an element retained against longitudinal displacement on said barrel, and a plurality of stepped portions on said seal abutment selectively engageable with said element.
  • a hypodermic syringe comprising a barrel open at one end for receiving anampoule of the type having a penetrable seal in one end capable of piston-like movement therein, a seal abutment located in the other end of said barrel and preliminarily adjustable therein to predeter- ⁇ mine the dosage subsequently injected by movement of said ampoule fully into said barrel, a double-ended needle carried at said other end of said barrel, said needle having a portion extending into said barrel beyond said seal abutment to penetrate said seal prior to its pistonlike movement resulting from movement of said ampoule after engagement of said seal abutment by said seal, said seal abutment comprising a tubular member surrounding said needle and step-by-step positioning meansV between said barrel and said seal abutment, said means comprising an element retained against longitudinal displacement on said barrel, and a plurality of stepped portions on said seal abutment selectively engageable with said element.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, a seal abutment located in the other end of said barrel and adjustable therein to predetermine the dosage A injected by movement of said ampoule ully into tions on said seal abutment selectively engageable With said element.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in the central opening, positioning means tor securing said seal abutment in differentpositions of adjustment to predetermine the dosage ⁇ injected by movement of said ampoule fully into said barrel, and a Adouble-,ended needle, carried at said other end of said barrel, said needle Whaving a portion extending into said barrel beyond said seal abutment to penetrate said seal prior to its piston-like movement resulting from movement of said ampoule after engagement of said seal abutment by said seal said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrel and selectively engageable with any one of said portions.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in the central opening, means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule fully into said barrel, and a double-ended needle carried at said other end of said barrel, said needle having a portion extending into said barrel beyond said seal abutment to penetrate said seal prior to its piston-like movement resulting from movement of said ampoule after engagement of said seal abutment by said seal, said means comprising a spring pressed element, said seal abutment having a plurality of openings for selective engagement by said element.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in said central opening, positioning means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule into engagement With the end Wall of said barrel, and a double-ended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrel and selectively engageable With any one of said portions.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having a central opening thereinya seal abutment slidably mounted in said central opening, positioning means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule into'engagement With theend Wall of said barrel, ⁇ and a 6 double-ended needle .having en. inn?
  • .geel-Dewi trating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient, said needle being formed from a single piece of metal carriedY by said seal abutment said positioning means comprising a plurality ofpositioning portionsspaced.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an endv into engagement With the end wall of said barrel, and a double-ended needle having aninne'r seal penetrating portion extending intosaid bar rel beyond said seal abutment and an outer portion for penetrating the skin of a patient, said needle being formed from a single piece of metal permanently carried by said seal abutment said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrel and selectively engageable with any one of said portions.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in said central opening, means for securing said seal abutment in diierent positions of adjustment to predetermine the dosage injected by movement of said ampoule into engagement With the end Wall of said barrel, and a double-ended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of apatient, the outer endfof said seal abutment being shaped to form a Luer tting, the outer portion of said needle having a Luer fitting and being removable from said abutment.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having 'a central opening therein, a seal abutment slidably mount'- ed in said central opening, means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule into engagement with the end Wall of said barrel, and a doubleendedrneedle having an inner seal penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient, the inner portion of said needle being permanently mounted in saidseal abutment, the outer end of said seal abutment being shaped to form a Luer iitting, the outer portion of said needle having a Luer tting and being removable from said abutment.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end wall at the other end of said barrel having a central securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule intoengagement with the end Wall of said barrel, and a doubleended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer 'portionfor Vpenetrating the skin of a patient, a coupling member detachably secured to the outer end of said abutment, the inner portion of said needle being carried by said coupling member said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrelandselectively engageable with any one of said portions.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable-seal in one end capable of piston-like movement therein, an end wall atthe other end of said barrel having a central opening therein, a seal abutment slidably mounted in said central opening, positioning means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule into engagement with the end wall of said barrel, and
  • a hypodermic syringe comprising a barrel open at'one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in said centraly opening, said central opening and said seal abutment having a non-circular cross section, a transverse passage in said end r wall communicating with said central opening, said abutment having a series of recesses in alignment With said passage, a positioning element slidable in said recess and selectively engageable With said recesses, resilient means urging said element toward said recesses, and a doubleended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in said central opening, said central opening and said seal abutment having a non-circular cross section, a transverse passage in said end wall communicating with said central opening, said abutment having a series of recesses in alignment with said passage, a positioning element slidable insaid recess and selectively engageable With saidl recesses, resilient means urging'fsaid element toward said recesses, and a double-ended needle'having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and anouter portion for penetrating the skin of a patient, one of the portions fof said needle being removablefrom said abutment.
  • a hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal-in one end capable of piston-like movement therein, an end Wall at' the other end of said barrel having -a central opening therein, a seal abutment slidably mounted in said central opening, said central opening and said seal abutment having a non-circular cross section, a transverse passage in said end Wall communicating with said central opening, said abutment having a series of recesses inalignment With said passage, a positioning element slidable in said recess and selectively engageable with said recesses, resilient means urging said elementY toward said recessesand a double-ended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient, the outer portion of said needle'having a Luer tting for detachably connecting it to said abutment.
  • a hypodermic syringe adapted to employ an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, said syringe comprising a barrel slidably receiving said ampoule, a hollow, double-ended needle at one end of said barrel, a seal-engaging abutment in said barrel, an ampoule-engaging abutment in said barrel, one oi said abutment's being adjustable longitudinally of ysaid barrel, and positioning means on said barrel retained against longitudinal movement relative thereto and selectively engageable with longitudinally spaced portions of said adjustable abutment to lock said adjustable abutment in position to predetermine the dosage subsequently administered by movement of said ampoule against'its' abutment.
  • a hypodermic syringe adapted to employ an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, said syringe comprising a barrel open atone end to receive the end ofthe ampoule having the penetrable seal therein, a hollow ⁇ double-ended needle at the other end of said barrel, seal-engaging abutment means at saidother end of the barrel, ampoule-engaging abutment means at said other end of the barrel, means for eiect-v ing relative adjustment longitudinally of said barrel between the seal and ampoule-engaging portions of said abutment means, includingl means for retaining said seal and ampoule engaging portions rigidly in a selected one of a plurality of positions of relative adjustment to predetermine the dosage subsequently administered'by' movement of said ampoule into said barrel against the ampoule engaging portion of the ampoule abutment means.

Description

May 22, 1951 A, W, BARRY 2,554,451
f HYPODERMIC SYRINGE Filed Sept. 16, 1946 2| IO H Am ye/ FIG.2.
FIGA. 25
INVENTOR.
AARON W. BARRY BY mwmmqlww' *KW ATTORNEYS Patented May 22, 1951 UNITED STATES PATENT OFFICE 19 Claims.
The present invention relates to a hypodermic syringe and more particularly to a hypodermic syringe of the type adapted to receive an ampoule having a seal received in one end and capableloil piston-like movement therein.
It is an object of the present invention in a hypodermic syringe of the character described' to provide means for predetermining dosage admin-` istered in fractions or multiples thereof of they contents of the syringe.
It is a further object of the present invention to provide a hypodermic syringe of the character described characterized by the removability and replaceability of either or both the inner and outer portions of the needle.
Figure 3 is a longitudinal view partly in sectiony of yet another embodiment of the improved hypodermic syringe; and
Figure 4 is a longitudinal view partly in section of a fourth embodiment of the present invention. Referring first to Figure l, the hypodermic syringe comprises a barrel lil having a generally cylindrical body portion open at one vendand having its opposite end closed by an end wall 2 which is provided with a central, preferably non circular opening I3 therein. The open end of the barrel I is provided with a pair of lateral projections I4 which serve as nger pieces during use of the syringe, as will subsequently be described.
The syringe is intended for use with an ampoule 20, which is illustrated as comprising an elon-V gated, generally cylindrical body formed of gl'a'ss and open at both ends. A central partition 2| is provided and the material to be administered is contained within the chambers 22 located withinv the ampoule outwardly from the central partition 2|. Each end of the ampoule 2t is provided with a seal 23 which is formed of a material easily penetrated by the end of a hollow needle but which is adapted to sealingly engage the needle after penetration. Certain rubber compositions are suitable for the seals and these are well known in the art. The seals 23 are adapted to have a piston-like sliding movement within the interior of the ampoule, for a purpose which will subsequently be described. A separate removable cap 25 is provided which :its over the outer end'4 of the ampoule 2li and cooperates with the finger pieces I4 previously described so that pressure l Other objects and features of the. invention may be applied therebetween to force the ampoule downwardly toward the closed end of the barrel.
Adjustably received within the central opening in the end wall E2 of the barrel is a seal stop 39 of the same cross sectional shape as the central opening i3 and which is slidably mounted therein.
In practice, other means could be employed for effecting adjustment of the seal stop 30 longitudi-v nally of the barrel Ii), las for example a threaded connection for the seal stop 3i! in the opening |3, but I have chosen to illustrate adjusting means which takes the form' of a locking element 3| slidable in a passage formed transversely of the end wall i2 and communicating with the central opening i3. A leaf spring 32 is secured to the outer surface of the barrel and is effective to urge the element 3| inwardly toward the seal abutment St. A plurality of recesses 33 are provided inthe outer wall of the seal abutment 3U in alignment with the element 3|. It is for the purpose of maintaining the series of recesses 33 in alignment with the element 3| that the central opening I3 and the seal abutment 3B are made of noncircular cross section, so as to prevent relative rotation therebetween.
Preferably the outer surface of the seal stop 3|]l A double-ended needle 35 is provided which in use is supported against movement relative to the barrel and the needle 35 has an inner portion/3,6 which extends inwardly of the barrel beyond the end of the seal stop 3@ and is adapted to penetrate the seal 23 as the ampoule 20 is moved to the right, as seen in this figure. The outer portion 31 of the needle extends outwardly beyond the end of the assembly and is the portion thereof which is adapted to penetrate the skin of a patient. In the embodiment illustrated in Figure l, the needle 35 is a unitary, integral, hol1ow,'metallic tube which is rigidly and' permanently secured to the seal abutment til. It will be observed tha-t in the preferred form of the invention the'seal abutment 3B at its inner end is of tubularconstruction having a central opening 38 through which the inner portion 36 of the needle extends. The end 39 of the seal abutment is adapted to engage the seal 23 after the inner portion 36 of' the needle has penetrated the seal 23. Further movement of the ampoule 2B to the right, as seen in Figure l, will result in a relative sliding movement of the piston-like seal 23 to the left, thus applying pressure to the liquid contained within the chamber 22 oi the ampoule, which in turn forces it outwardly through the needle 35. It will be apparent from an inspection of this ligure that the dosage administered by full movement of the ampoule into the barrel Ill, which movementis limited by the engagement of the end of `the Ya male Luer tting iii.
fassa-isi is a predetermined fraction or multiple thereof of the contents of the chamber 22 when lled. It will further be observed that employing the double-ended ampoule illustratedY in Figure 1; after the material at one end o f the ampoule is exhausted the ampoule may be reversed in the barrel and the material in the other end thereof administered in like manner.
The modification illustrated in Figure 2 is essentially similar to that illustrated in Figure l and onlythe feature of difference will be described. In this modification the tube abutment illustrated at 40 has its outer portion formed as The outer portion l2 of the needle is provided with a conventional female Luer type tting 43. This construction permits replacement of the outer portion of the needle as the same becomes dulled or otherwise unsuitable for continued use. IThe inner portion l of the double-ended needle in this modication is permanently secured to the tube abutment 4B.
Referring now to Figure 3, a somewhat different embodiment oi the invention is illustrated.v In this modification the outer end of the seal abutment 59 is provided with threads as indicated at 5l for receiving a coupling 52. The coupling 52 at its outer end is provided with a male Luer type tting 53 which is adapted to receive a similar Luer type fitting 54 secured to the outer portion 55 of the double-ended needle. In this modication the inner portion 56 of the double-ended needle is permanently secured to the coupling 52. As a result, both the outer portion 55 and the inner portion 58 of the double-ended needle may be replaced independently as desired.
Referring now to Figure 4, yetl yanother embodiment of the invention is illustrated in which the seal stop G is provided with threads at its outer end as indicated at 6 I. A cooperatingly threaded tting 52 is provided which screws over the thread 5|. The tting E2 carries the double-ended needle, having an outer portion 63 and an inner portion E4. In this case the double-ended needle is a single integral needle of the type illustrated in Figure l, but may be replaced in the tube stop G, as is plainly apparent from Figure 4.
While I have illustrated and described in considerable detail fourspecifio embodiments Vof my improved hypodermic syringe, it will be appreciated that this full illustration and description has been given merely to enable those skilled in the art to practice the invention, the scope of which is indicated by the appended claims.
What I claim as my invention is:
1. A hypodermic syringe adapted to employ an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, said syringe comprising a barrel open at one end to receive the end of the ampoule having the penetrable seal therein, a hollow doubledended needle at the othery end of said barrel, a seal-engaging abutment at said other end o the barrel, an ampoule-engaging abutment at said other end of the barrel, means mounting one of said abutments for movement longitudinally of said barrel relative to the other abutment, and rigid step-by-step positioning means for retaining said movable abutment rigidly in a selected one of a plurality of positions of adjustment rel-A ative to the other abutment to predetermine the dosage subsequently administered by movement of said ampoule into said barrel against its abutment.
2. A syringe as defined in claim l, in which said positioning means includes selectively engageable step-by-step positioning elements carried by said barrel and the movable abutment and effective to so position said abutments as to administer predetermined fractions or multiples thereof of the contents of said ampoule in successive injections.
3. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, said barrel being closed at the other end to provide a stop for theinward movement of said ampoule into said barrel, a seal abutment located in the other end of said barrel and adjustable therein to predetermine the dosage injected by movement of said ampoule fully into said barrel, a doubleended needle carried at said other end of said barrel, said needle having a portion extending into said barrel beyond said seal abutment to penetrate said seal prior to its piston-like movement resulting from movement of said ampoule after engagement of said seal abutment by said seal and step-by-step positioning means between said barrel and said seal abutment, said means comprising an element retained against longitudinal displacement on said barrel, and a plurality of stepped portions on said seal abutment selectively engageable with said element.
4. A hypodermic syringe comprising a barrel open at one end for receiving anampoule of the type having a penetrable seal in one end capable of piston-like movement therein, a seal abutment located in the other end of said barrel and preliminarily adjustable therein to predeter- `mine the dosage subsequently injected by movement of said ampoule fully into said barrel, a double-ended needle carried at said other end of said barrel, said needle having a portion extending into said barrel beyond said seal abutment to penetrate said seal prior to its pistonlike movement resulting from movement of said ampoule after engagement of said seal abutment by said seal, said seal abutment comprising a tubular member surrounding said needle and step-by-step positioning meansV between said barrel and said seal abutment, said means comprising an element retained against longitudinal displacement on said barrel, and a plurality of stepped portions on said seal abutment selectively engageable with said element.
5. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, a seal abutment located in the other end of said barrel and adjustable therein to predetermine the dosage A injected by movement of said ampoule ully into tions on said seal abutment selectively engageable With said element.
6. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in the central opening, positioning means tor securing said seal abutment in differentpositions of adjustment to predetermine the dosage `injected by movement of said ampoule fully into said barrel, and a Adouble-,ended needle, carried at said other end of said barrel, said needle Whaving a portion extending into said barrel beyond said seal abutment to penetrate said seal prior to its piston-like movement resulting from movement of said ampoule after engagement of said seal abutment by said seal said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrel and selectively engageable with any one of said portions.
7. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in the central opening, means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule fully into said barrel, and a double-ended needle carried at said other end of said barrel, said needle having a portion extending into said barrel beyond said seal abutment to penetrate said seal prior to its piston-like movement resulting from movement of said ampoule after engagement of said seal abutment by said seal, said means comprising a spring pressed element, said seal abutment having a plurality of openings for selective engagement by said element.
8. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in said central opening, positioning means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule into engagement With the end Wall of said barrel, and a double-ended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrel and selectively engageable With any one of said portions.
9. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having a central opening thereinya seal abutment slidably mounted in said central opening, positioning means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule into'engagement With theend Wall of said barrel, `and a 6 double-ended needle .having en. inn? .geel-Dewi trating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient, said needle being formed from a single piece of metal carriedY by said seal abutment said positioning means comprising a plurality ofpositioning portionsspaced.
longitudinally of said seal abutment, and an element carried by said barrel and selectively engageable with any one of said portion. e
10. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an endv into engagement With the end wall of said barrel, and a double-ended needle having aninne'r seal penetrating portion extending intosaid bar rel beyond said seal abutment and an outer portion for penetrating the skin of a patient, said needle being formed from a single piece of metal permanently carried by said seal abutment said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrel and selectively engageable with any one of said portions.
1l. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in said central opening, means for securing said seal abutment in diierent positions of adjustment to predetermine the dosage injected by movement of said ampoule into engagement With the end Wall of said barrel, and a double-ended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of apatient, the outer endfof said seal abutment being shaped to form a Luer tting, the outer portion of said needle having a Luer fitting and being removable from said abutment. 12. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end Wall at the other end of said barrel having 'a central opening therein, a seal abutment slidably mount'- ed in said central opening, means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule into engagement with the end Wall of said barrel, and a doubleendedrneedle having an inner seal penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient, the inner portion of said needle being permanently mounted in saidseal abutment, the outer end of said seal abutment being shaped to form a Luer iitting, the outer portion of said needle having a Luer tting and being removable from said abutment.
13. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end wall at the other end of said barrel having a central securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule intoengagement with the end Wall of said barrel, and a doubleended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer 'portionfor Vpenetrating the skin of a patient, a coupling member detachably secured to the outer end of said abutment, the inner portion of said needle being carried by said coupling member said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrelandselectively engageable with any one of said portions. -Y
14. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable-seal in one end capable of piston-like movement therein, an end wall atthe other end of said barrel having a central opening therein, a seal abutment slidably mounted in said central opening, positioning means for securing said seal abutment in different positions of adjustment to predetermine the dosage injected by movement of said ampoule into engagement with the end wall of said barrel, and
a double-ended needle having an inner seal-pene- .n
trating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient, a coupling member detachably secured to the outer end of said abutment, the outer portion of said needle being carried by said coupling member said positioning means comprising a plurality of positioning portions spaced longitudinally of said seal abutment, and an element carried by said barrel and selectively engageable with any one of said portions. Y
15. A hypodermic syringe comprising a barrel open at'one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in said centraly opening, said central opening and said seal abutment having a non-circular cross section, a transverse passage in said end r wall communicating with said central opening, said abutment having a series of recesses in alignment With said passage, a positioning element slidable in said recess and selectively engageable With said recesses, resilient means urging said element toward said recesses, and a doubleended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient.
16. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, an end wall at the other end of said barrel having a central opening therein, a seal abutment slidably mounted in said central opening, said central opening and said seal abutment having a non-circular cross section, a transverse passage in said end wall communicating with said central opening, said abutment having a series of recesses in alignment with said passage, a positioning element slidable insaid recess and selectively engageable With saidl recesses, resilient means urging'fsaid element toward said recesses, and a double-ended needle'having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and anouter portion for penetrating the skin of a patient, one of the portions fof said needle being removablefrom said abutment.
17. A hypodermic syringe comprising a barrel open at one end for receiving an ampoule of the type having a penetrable seal-in one end capable of piston-like movement therein, an end Wall at' the other end of said barrel having -a central opening therein, a seal abutment slidably mounted in said central opening, said central opening and said seal abutment having a non-circular cross section, a transverse passage in said end Wall communicating with said central opening, said abutment having a series of recesses inalignment With said passage, a positioning element slidable in said recess and selectively engageable with said recesses, resilient means urging said elementY toward said recessesand a double-ended needle having an inner seal-penetrating portion extending into said barrel beyond said seal abutment and an outer portion for penetrating the skin of a patient, the outer portion of said needle'having a Luer tting for detachably connecting it to said abutment.
18. A hypodermic syringe adapted to employ an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, said syringe comprising a barrel slidably receiving said ampoule, a hollow, double-ended needle at one end of said barrel, a seal-engaging abutment in said barrel, an ampoule-engaging abutment in said barrel, one oi said abutment's being adjustable longitudinally of ysaid barrel, and positioning means on said barrel retained against longitudinal movement relative thereto and selectively engageable with longitudinally spaced portions of said adjustable abutment to lock said adjustable abutment in position to predetermine the dosage subsequently administered by movement of said ampoule against'its' abutment. p
19. A hypodermic syringe adapted to employ an ampoule of the type having a penetrable seal in one end capable of piston-like movement therein, said syringe comprising a barrel open atone end to receive the end ofthe ampoule having the penetrable seal therein, a hollow` double-ended needle at the other end of said barrel, seal-engaging abutment means at saidother end of the barrel, ampoule-engaging abutment means at said other end of the barrel, means for eiect-v ing relative adjustment longitudinally of said barrel between the seal and ampoule-engaging portions of said abutment means, includingl means for retaining said seal and ampoule engaging portions rigidly in a selected one of a plurality of positions of relative adjustment to predetermine the dosage subsequently administered'by' movement of said ampoule into said barrel against the ampoule engaging portion of the ampoule abutment means. f
AARON W. BARRY.
REFERENCES CITED The following references are of record in the file of this patent:
UNITED STATES PATENTS Number Name Date 1,909,591 Nevin May 16, 1933 2,153,594 Sair Apr. 11, 1939 2,408,323 Lockhart Sept. 24,1946 12,409,656. ,.f. Austin Oct. 22, A946'.
US697298A 1946-09-16 1946-09-16 Hypodermic syringe Expired - Lifetime US2554451A (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2939459A (en) * 1957-01-11 1960-06-07 Jorge A Lazarte Tandem syringe
US4034755A (en) * 1975-09-16 1977-07-12 Hamilton Company Syringe
US4356822A (en) * 1980-10-17 1982-11-02 Winstead Hall Deborah Syringe assembly
FR2573310A1 (en) * 1984-11-20 1986-05-23 Poutrait Morin BULB FOR HYPODERMIC SYRINGE, IN PARTICULAR SELF-INJECTING SYRINGE
WO1999036114A3 (en) * 1998-01-20 1999-10-07 Tecnologia S A S Di Valentino Device of the manual syringe type for proportioning and dispensing fluid or pasty products
WO2000043057A1 (en) 1999-01-21 2000-07-27 Tecnologia S.A.S Di Valentino Brazzale & C. A device for injecting a fluid product
WO2012041870A1 (en) * 2010-10-01 2012-04-05 Sanofi-Aventis Deutschland Gmbh Needle assembly with release mechanism
US20160243313A1 (en) * 2015-02-24 2016-08-25 Teleflex Medical Incorporated Dose divider syringe
US11246996B2 (en) * 2012-12-26 2022-02-15 Becton, Dickinson And Company Pen needle assembly

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1909591A (en) * 1928-06-20 1933-05-16 Novocol Chemical Mfg Co Inc Method of utilizing hypodermic medicaments, etc.
US2153594A (en) * 1934-06-25 1939-04-11 Multiple Corp Hypodermic syringe and cartridge therefor
US2408323A (en) * 1943-06-10 1946-09-24 Margaret L Lockhart Hypodermic syringe
US2409656A (en) * 1945-04-20 1946-10-22 Harold S Austin Hypodermic syringe

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1909591A (en) * 1928-06-20 1933-05-16 Novocol Chemical Mfg Co Inc Method of utilizing hypodermic medicaments, etc.
US2153594A (en) * 1934-06-25 1939-04-11 Multiple Corp Hypodermic syringe and cartridge therefor
US2408323A (en) * 1943-06-10 1946-09-24 Margaret L Lockhart Hypodermic syringe
US2409656A (en) * 1945-04-20 1946-10-22 Harold S Austin Hypodermic syringe

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2939459A (en) * 1957-01-11 1960-06-07 Jorge A Lazarte Tandem syringe
US4034755A (en) * 1975-09-16 1977-07-12 Hamilton Company Syringe
US4356822A (en) * 1980-10-17 1982-11-02 Winstead Hall Deborah Syringe assembly
FR2573310A1 (en) * 1984-11-20 1986-05-23 Poutrait Morin BULB FOR HYPODERMIC SYRINGE, IN PARTICULAR SELF-INJECTING SYRINGE
WO1999036114A3 (en) * 1998-01-20 1999-10-07 Tecnologia S A S Di Valentino Device of the manual syringe type for proportioning and dispensing fluid or pasty products
WO2000043057A1 (en) 1999-01-21 2000-07-27 Tecnologia S.A.S Di Valentino Brazzale & C. A device for injecting a fluid product
WO2012041870A1 (en) * 2010-10-01 2012-04-05 Sanofi-Aventis Deutschland Gmbh Needle assembly with release mechanism
US8864740B2 (en) 2010-10-01 2014-10-21 Sanofi-Aventis Deutschland Gmbh Needle assembly with release mechanism
US11246996B2 (en) * 2012-12-26 2022-02-15 Becton, Dickinson And Company Pen needle assembly
US20160243313A1 (en) * 2015-02-24 2016-08-25 Teleflex Medical Incorporated Dose divider syringe
US10420894B2 (en) * 2015-02-24 2019-09-24 Teleflex Medical Incorporated Dose divider syringe

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