US2594296A - Lobeline aerosol dilating medicament - Google Patents
Lobeline aerosol dilating medicament Download PDFInfo
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- US2594296A US2594296A US35059A US3505948A US2594296A US 2594296 A US2594296 A US 2594296A US 35059 A US35059 A US 35059A US 3505948 A US3505948 A US 3505948A US 2594296 A US2594296 A US 2594296A
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- lobeline
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- dilating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
Definitions
- This invention relates to medical compositions for use in aerosol therapy, especially for opening or enlarging the passages in the respiratory system; and it relates particularly to synergistic compositions comprising as primary and essential ingredients a procaine salt and a lobeline salt, or a cocaine salt and a lobeline salt.
- Aerosol therapy has become very important in the treatment of respiratory diseases or pathological conditions, e. g., in the treatment of bronchitis, tuberculosis, asthma, and the like, and also in the treatment of other diseases or pathological conditions by absorption of drugs through the respiratory system and transport of the drugs to other parts of the body by means of the blood circulatory system.
- pneumo-dilating therapeutic agents suitable for administration in the form of aerosols, for relieving constriction and for penetrating the innermost passages (alveoli) of the lungs, and. for providing increased absorption area.
- One of the objects of the invention is to produce a pneumo-dilating composition having an action which is prompt, effective and long-lastirig. Another object is to produce therapeutic agents which may be effectively administered in the form of aerosols in the respiratory system.
- therapeutic agents suitable for administration in the form of aerosols comprising preparations containing a lobeline salt, e. g., lobelia alkaloid, and a procaine salt or a cocaine salt, and containing also as desired, one or more additional agents, such added agents including antiseptics, anti-secretive agents, surface tension lowering agents, agents modifying the tonus of smooth muscles, etc.
- a lobeline salt e. g., lobelia alkaloid
- procaine salt or a cocaine salt containing also as desired, one or more additional agents, such added agents including antiseptics, anti-secretive agents, surface tension lowering agents, agents modifying the tonus of smooth muscles, etc.
- Example 1 The synergistic eifect of the lobelia-procaine composition of Example 1 is apparent. With only one-half as much of the lobelia salt, as in comparative Example A, together with only one-- half as much as the procaine salt, as in com-- parative Example B, the Example 1 effect is of. the order of double the additive effect, or more. both as to dilation range and also as to the duration of the dilation, each of which varies in view of the variations in the average lung volume change of each of the human subjects used.
- the tincture of lobelia may be an alcoholic extract containing 10% of lobelia constituents in the form of their naturally occurring alkaloids, the principal one of which is lobeline.
- Examplev 1 composition is particularly useful for the relief of various kinds of pneumoconstrictions, such as those caused by allergies, irritants, dusts, and the like, as mentioned hereinabove; and this composition may be diluted e. g., with distilled water with satisfactory results, even down to a five-fold dilution.
- composition of the invention suitable for inhalation as an aerosol is:
- This composition also shows the synergistic effect, and may be used like the composition of Example'l.
- lobeline salt compositions containing either a procaine salt or a cocaine salt, or both, even in rela--- tively small amounts.
- the preferred compositions contain per part of lobeline salt (lobeline part), 1 to 5 parts of procaine salt (procaine part) or 1 to 2.5 parts of cocaine salt (cocaine part).
- compositions in the form of solutions are preferred, in view of their great lung penetrating power when administered as very fine aerosols and also in view of the facility with which dosage is controlled, the compositions, in substantially the above-mentioned proportions, may be in dry or solid form. In such case they would preferably be suitably diluted with an inert material in a sterilized and fine powdered form, to pass into the innermost respiratory regions. The slight constriction known to normally appear after inhalation of powders is easily overcome by the dilating agent.
- compositions of the invention are used in the form of solutions, the particular dilution or concentration thereof isdependent upon the degree or intensity of medication desired.
- an aqueous composition containing from 0.2 to 2% of procaine hydrochloride and from 0.1 to 0.5% lobeline sulfate produces satisfactory medication.
- a more concentrated solution which when dispersed as an aerosol will provide effective dilation with but a single inspiration of the aerosol contains about 0.2% lobeline hydrochloride and either 2% procaine hydrochloride or 1% cocaine sulfate.
- Less concentrated solutions than the above may be employed according to the sensitivity of the subject, but I have found. that solutions containing less than about 0.1% lobeline alkaloid salt, e. g., sulfate and less than about 0.1% procaine or cocaine salt, e. g., hydrochloride, require a longer time to produce the requisite degree of dilation.
- Solvents other than water may be used. in: such compositions. Replacement of some or' all; of the water in the above-mentioned solutions by a lower glycol compound, e. g., ethylene glycol, diethylene glycol, triethylene. glycol 01'. pro.- pylene glycol results in an increased therapeutic efficacy and prolongation of. the duration of therapeutic effect.
- a lower glycol compound e. g., ethylene glycol, diethylene glycol, triethylene. glycol 01'. pro.- pylene glycol
- These materials may berepresented by the formula is preferred to employ the aboveglycols in .aque ous solutions of concentrations of about- 20-toabout 80%, since these concentrations provide.
- the pneumo-dilating compositions of the invention may be used directly as pneumo-dilating agents to relieve various kinds of pneumo-constrictions, such as those caused by allergies, irritants, caustics, infections, dusts, powders, and the like. They may be used before or together with i.
- medicating agents such as antiseptics for the respiratory system, for example, guaiacol, guaiacol salts, creosote, menthol, eucalyptol, penicillin, streptomycin, sulfa drugs, and the like; anti-secretive materials, uch as an atropine salt; tonic agents for the blood vessels, such as a strychnine salt; or other agents, such as ethylene glycol, propylene glycol, diethylene glycol, triethylene glycol, and the like, or any other drug with systemic action.
- medicating agents such as antiseptics for the respiratory system, for example, guaiacol, guaiacol salts, creosote, menthol, eucalyptol, penicillin, streptomycin, sulfa drugs, and the like
- anti-secretive materials uch as an atropine salt
- tonic agents for the blood vessels such as a strychnine salt
- agents such as
- the lobelia-procaine-glycol composition of Example 3 shows an additional and improved effect as compared to the lobelia-procaine composition of Example 1 and the glycol of comparative Example C, even though the amount of glycol inhaled in the Example 3 test is comparable to only about 10% the amount inhaled in the Example C test.
- composition illustrates a very effective pneumo-dilating and expectorant composition, which is useful for and has found good acceptance .by medical practitioners for treatment ofchronic asthma, chronic bronchitis, bronchiectasis, etc. by dispersion as an aerosol and inhalation:
- Example 4 Grams Lobelia (10%.tincture of) 10- Procaine hydrochloride 2' Guaiacol 0.25 Potassium sulfoguaiacolate 2 Ethylene glycol 10 Water 75.75
- aqueous solution con- 800 to 1300... 4 to 10.
- the atropine strychmne lobeha procaine composition of Example 6 shows an improved effect (synergism), even though the atropine material therein is present in only one-fifth the amount in the comparative Example D test.
- the following example illustrates a particularly effective pneumo-dilating and anti-secretive composition, which has found good acceptance by medical practitioners, for the treatment of asthma accompanied by bronchorrhea, chronic bronchitis, bronchiectasis, and the like by dispersion in the form of an aerosol and inhalation:
- Example 7 Grams Lobeline sulfate 0.1 Procaine hydrochloride 0.1 Atropine sulfate 0.2 Strychnine sulfate 0.2 Ethylene gly 10.0 Water 89.4
- a composition suitable for the treatment of infectious asthma or respiratory infections is as fol-
- other water-soluble salts may be used, using an equivalent efiective concentration of the alkaloid.
- the free alkaloids may be compounded in the abovedisclosed proportions, but it is preferred to administer the compositions in convenient soluble salt form.
- cocaine compositions are not to be used except with the usual precautions for cocaine.
- a soluble nicotine material such as the sulfate, or the like, may be used in place of the lobeline material in certain instances, but, of course, the resulting compositions are not to be used except with the precautions usual for a nicotine material.
- a composition comprising as essential and primary ingredients, a lobeline salt and a salt selected from the group consisting of salts of procaine and of cocaine, said composition being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating effect.
- composition of claim 1 in the form of a solution containing at least 0.1% of each salt component.
- a composition comprising as essential and primary ingredients, a lobeline salt, a procaine salt and a respiratory antiseptic material, said composition'being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating effect.
- a composition comprising as essential and primary ingredients, a lobeline salt, a procaine salt and a stimulating agent for the central nervous system, said composition being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating effect.
- a composition comprising as essential and primary ingredients, a lobeline salt, a procaine salt and guaiacol said composition being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating eifect.
- a composition comprising as essential and primary ingredients, 2. lobeline salt, a procaine salt, an atropine salt and a strychnine salt, said composition being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating effect.
- a composition comprising as essential and primary ingredients, a lobeline salt and a salt selected from the group consisting of salts of procaine and of cocaine, in a sterilized and fine powdered form.
Description
Patented Apr. 29, 1952 UNITED STATES PATENT OFFICE LOBELINE AEROSOL DILATING MEDICAMEN'I.
No Drawing. Application June 24, 1948, Serial No. 35,059
7 Claims.
This invention relates to medical compositions for use in aerosol therapy, especially for opening or enlarging the passages in the respiratory system; and it relates particularly to synergistic compositions comprising as primary and essential ingredients a procaine salt and a lobeline salt, or a cocaine salt and a lobeline salt.
Aerosol therapy has become very important in the treatment of respiratory diseases or pathological conditions, e. g., in the treatment of bronchitis, tuberculosis, asthma, and the like, and also in the treatment of other diseases or pathological conditions by absorption of drugs through the respiratory system and transport of the drugs to other parts of the body by means of the blood circulatory system.
An important problem confronting the art of aerosol therapy is the dilation (enlargement) of the respiratory passages so that aerosols may penetrate to the innermost regions or passages in the lungs, and to provide maximum surface or absorption area for absorbing the drugs.
In accordance with the invention, there are provided pneumo-dilating therapeutic agents suitable for administration in the form of aerosols, for relieving constriction and for penetrating the innermost passages (alveoli) of the lungs, and. for providing increased absorption area.
One of the objects of the invention is to produce a pneumo-dilating composition having an action which is prompt, effective and long-lastirig. Another object is to produce therapeutic agents which may be effectively administered in the form of aerosols in the respiratory system.
Other objects will be apparent as the details or embodiments of the invention are set forth hereinafter.
In accordance with the present invention there are provided therapeutic agents suitable for administration in the form of aerosols comprising preparations containing a lobeline salt, e. g., lobelia alkaloid, and a procaine salt or a cocaine salt, and containing also as desired, one or more additional agents, such added agents including antiseptics, anti-secretive agents, surface tension lowering agents, agents modifying the tonus of smooth muscles, etc.
In order to facilitate a clear understanding of the invention,'the following non-limitative illustrative examples are given. The pneumodilating efliciency of the compositions is tested by volumetric pneumography, in accordance with published procedures, and the following data are typical of results obtained with the compositions of the invention. All parts, amounts and percentages herein are by weight unless otherwise specified.
The synergistic eifect of the lobelia-procaine composition of Example 1 is apparent. With only one-half as much of the lobelia salt, as in comparative Example A, together with only one-- half as much as the procaine salt, as in com-- parative Example B, the Example 1 effect is of. the order of double the additive effect, or more. both as to dilation range and also as to the duration of the dilation, each of which varies in view of the variations in the average lung volume change of each of the human subjects used.
The tincture of lobelia may be an alcoholic extract containing 10% of lobelia constituents in the form of their naturally occurring alkaloids, the principal one of which is lobeline.
This Examplev 1 composition is particularly useful for the relief of various kinds of pneumoconstrictions, such as those caused by allergies, irritants, dusts, and the like, as mentioned hereinabove; and this composition may be diluted e. g., with distilled water with satisfactory results, even down to a five-fold dilution.
Another illustrative composition of the invention suitable for inhalation as an aerosol is:
This composition also shows the synergistic effect, and may be used like the composition of Example'l.
The synergistic effect is characteristic of lobeline salt compositions containing either a procaine salt or a cocaine salt, or both, even in rela--- tively small amounts. For maximum therapeutic effect, however, the preferred compositions contain per part of lobeline salt (lobeline part), 1 to 5 parts of procaine salt (procaine part) or 1 to 2.5 parts of cocaine salt (cocaine part).
Although compositions in the form of solutions are preferred, in view of their great lung penetrating power when administered as very fine aerosols and also in view of the facility with which dosage is controlled, the compositions, in substantially the above-mentioned proportions, may be in dry or solid form. In such case they would preferably be suitably diluted with an inert material in a sterilized and fine powdered form, to pass into the innermost respiratory regions. The slight constriction known to normally appear after inhalation of powders is easily overcome by the dilating agent.
When the compositions of the invention are used in the form of solutions, the particular dilution or concentration thereof isdependent upon the degree or intensity of medication desired. For general administration, an aqueous composition containing from 0.2 to 2% of procaine hydrochloride and from 0.1 to 0.5% lobeline sulfate produces satisfactory medication. A more concentrated solution which when dispersed as an aerosol will provide effective dilation with but a single inspiration of the aerosol contains about 0.2% lobeline hydrochloride and either 2% procaine hydrochloride or 1% cocaine sulfate. Less concentrated solutions than the above may be employed according to the sensitivity of the subject, but I have found. that solutions containing less than about 0.1% lobeline alkaloid salt, e. g., sulfate and less than about 0.1% procaine or cocaine salt, e. g., hydrochloride, require a longer time to produce the requisite degree of dilation.
Solvents other than water may be used. in: such compositions. Replacement of some or' all; of the water in the above-mentioned solutions by a lower glycol compound, e. g., ethylene glycol, diethylene glycol, triethylene. glycol 01'. pro.- pylene glycol results in an increased therapeutic efficacy and prolongation of. the duration of therapeutic effect. These materialsmay berepresented by the formula is preferred to employ the aboveglycols in .aque ous solutions of concentrations of about- 20-toabout 80%, since these concentrations provide.
a substantial increaseinv thetherapeutie activity of the dilating compositions but do not increase the viscosity of the solutions to such an extent that the production of aerosols therefrom is made difficult. Care should be taken to use only pure glycols since even relatively small amounts of the impurities as frequently are present in crude glycol are constrictive in effect and may even produce an asthmatic crisis.
The pneumo-dilating compositions of the invention may be used directly as pneumo-dilating agents to relieve various kinds of pneumo-constrictions, such as those caused by allergies, irritants, caustics, infections, dusts, powders, and the like. They may be used before or together with i. e., include other medicating agents, such as antiseptics for the respiratory system, for example, guaiacol, guaiacol salts, creosote, menthol, eucalyptol, penicillin, streptomycin, sulfa drugs, and the like; anti-secretive materials, uch as an atropine salt; tonic agents for the blood vessels, such as a strychnine salt; or other agents, such as ethylene glycol, propylene glycol, diethylene glycol, triethylene glycol, and the like, or any other drug with systemic action.
The following (non-limitative) example and table illustrate a glycol-containing composition and the improved dilation effect obtained therewith.
TABLE II Volume of Dilation Ex- Aerosol Range (Maxi g g gi ample Aerosol of Inhaled mum Increase tie (in '0. (in in Lung Volwill? 5) Liters) ume, in 00.) 1 e l aqueous solution (2011- i0 500 to 1000. 4 to 10.
taining 5% of Tincture of Lobelia and 1% of Procainc Hydrochloride. G purcEtliylene Glycol i0 200 to 70(l 2 to 3.
or pure Propylene 3 aqueous solution con- 10 500 to 1400." 5 to 10.
taining 5% of Tincture of Lobelia and 1% of Procaine Hydrochloride plus 10% of Ethylene or Propylene Glycol.
The lobelia-procaine-glycol composition of Example 3 shows an additional and improved effect as compared to the lobelia-procaine composition of Example 1 and the glycol of comparative Example C, even though the amount of glycol inhaled in the Example 3 test is comparable to only about 10% the amount inhaled in the Example C test.
This type of effect is also obtained if any of the other above-mentioned glycols are used in proportions in the range of 1 to 20 parts of the glycol per 20 parts of the lobelia-procaine solution.
The following specific composition illustrates a very effective pneumo-dilating and expectorant composition, which is useful for and has found good acceptance .by medical practitioners for treatment ofchronic asthma, chronic bronchitis, bronchiectasis, etc. by dispersion as an aerosol and inhalation:
Example 4 Grams Lobelia (10%.tincture of) 10- Procaine hydrochloride 2' Guaiacol 0.25 Potassium sulfoguaiacolate 2 Ethylene glycol 10 Water 75.75
Total 100.00
The following (non-limitative) examples and table illustrate other compositions and the improved dilation efiect obtained therewith.
TABLE III Volumeof Dilation Ex- Aerosol Range (Maxig g ig aple Aerosol of 1nl(1 a1ed mulmlncrxease tion (in o. 111 111 ung o Liters) ume,incc.) Mmutes) D aqueous solution con- 10 300 to 500.-.. 2 to 4.
taining 1% of Atropine Sulfate. E aqueous solution con- 10 100 to 200.... l to 2.
taining 0.2% Strychnlne Sulfate. b aqueous solution con- 10 400 to 600... 2 to 4.
ts 1% of Procalne Sulfate, 0.6% of (10%);Tincture of Lobelia. aqueous solution con- 800 to 1300... 4 to 10.
taining: Atropine Sulfate, 0.2% of Strychnine Sulfate 0.5% of 10%) Tlncture of obelia, and 0.1% of Procaine Sulfate.
The atropine strychmne lobeha procaine composition of Example 6 shows an improved effect (synergism), even though the atropine material therein is present in only one-fifth the amount in the comparative Example D test.
The following example illustrates a particularly effective pneumo-dilating and anti-secretive composition, which has found good acceptance by medical practitioners, for the treatment of asthma accompanied by bronchorrhea, chronic bronchitis, bronchiectasis, and the like by dispersion in the form of an aerosol and inhalation:
Example 7 Grams Lobeline sulfate 0.1 Procaine hydrochloride 0.1 Atropine sulfate 0.2 Strychnine sulfate 0.2 Ethylene gly 10.0 Water 89.4
Total 100.0
A composition suitable for the treatment of infectious asthma or respiratory infections is as fol- In place of the alkaloid salts mentioned, other water-soluble salts may be used, using an equivalent efiective concentration of the alkaloid. The free alkaloids may be compounded in the abovedisclosed proportions, but it is preferred to administer the compositions in convenient soluble salt form. Of course, cocaine compositions are not to be used except with the usual precautions for cocaine. A soluble nicotine material, such as the sulfate, or the like, may be used in place of the lobeline material in certain instances, but, of course, the resulting compositions are not to be used except with the precautions usual for a nicotine material.
In view of the foregoing disclosures, variations and modifications thereof will be apparent to those skilled in the art, and all such variations and modifications are contemplated broadly within the invention.
, I claim:
1. A composition comprising as essential and primary ingredients, a lobeline salt and a salt selected from the group consisting of salts of procaine and of cocaine, said composition being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating effect.
2. The composition of claim 1 in the form of a solution containing at least 0.1% of each salt component.
3. A composition comprising as essential and primary ingredients, a lobeline salt, a procaine salt and a respiratory antiseptic material, said composition'being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating effect.
4. A composition comprising as essential and primary ingredients, a lobeline salt, a procaine salt and a stimulating agent for the central nervous system, said composition being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating effect.
5. A composition comprising as essential and primary ingredients, a lobeline salt, a procaine salt and guaiacol said composition being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating eifect.
6. A composition comprising as essential and primary ingredients, 2. lobeline salt, a procaine salt, an atropine salt and a strychnine salt, said composition being adapted for dispersion in the form of an aerosol and inhalation to produce a pneumo-dilating effect.
7. A composition comprising as essential and primary ingredients, a lobeline salt and a salt selected from the group consisting of salts of procaine and of cocaine, in a sterilized and fine powdered form.
LUCIEN DAUTREBANDE.
REFERENCES CITED The following references are of record in the file of this patent:
UNITED STATES PATENTS Number Name Date 1,723,459 Panalle Aug. 6, 1929 2,369,711 Blythe Feb. 20. 1945 2,414,918 Abramson Jan. 28, 1947 OTHER REFERENCES Hazard et al., Comp. Rend. Soc. Biol, vol 138,
Claims (1)
1. A COMPOSITION COMPRISING AS ESSENTIAL AND PRIMARY INGREDIENTS, A LOBELINE SALT AND A SALT SELECTED FROM THE GROUP CONSISTING OF SALTS OF PROCAINE AND OF COCAINE, SAID COMPOSITION BEING ADAPTED FOR DISPERSION IN THE FORM OF AN AEROSOL AND INHALATION TO PRODUCE A PNEUMO-DILATING EFFECT.
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Application Number | Priority Date | Filing Date | Title |
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US35059A US2594296A (en) | 1948-06-24 | 1948-06-24 | Lobeline aerosol dilating medicament |
Applications Claiming Priority (1)
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US35059A US2594296A (en) | 1948-06-24 | 1948-06-24 | Lobeline aerosol dilating medicament |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2745786A (en) * | 1952-04-02 | 1956-05-15 | Promidel Soc | Method of producing stable theophyllinic aerosols |
US3014844A (en) * | 1957-01-31 | 1961-12-26 | Riker Laboratories Inc | Self-propelling powder dispensing compositions |
US3076745A (en) * | 1958-11-17 | 1963-02-05 | Poultry Service And Res Corp | Antibiotic method for promoting poultry growth |
FR2625677A1 (en) * | 1988-01-07 | 1989-07-13 | Cosnier Alain | Medicinal composition intended for administration in aerosol form |
US4906641A (en) * | 1988-10-27 | 1990-03-06 | Leitman Esther M | Anti-micturition composition and method |
US5075314A (en) * | 1988-10-27 | 1991-12-24 | Leitman Esther M | Antimicturition composition and novel method |
US5075312A (en) * | 1988-10-27 | 1991-12-24 | Leitman Esther M | Novel anti-micturition composition and method |
US20060134008A1 (en) * | 2004-12-16 | 2006-06-22 | Daniel Deaver | Compositions and methods for pulmonary conditions |
US20110245270A1 (en) * | 2001-03-23 | 2011-10-06 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1723459A (en) * | 1927-06-29 | 1929-08-06 | Sam L Needle | Medicine for bronchial affections |
US2369711A (en) * | 1942-03-17 | 1945-02-20 | Smith Kline French Lab | Medicinal preparation |
US2414918A (en) * | 1941-09-23 | 1947-01-28 | Abramson Harold Alexander | Solutions for the improved nebulization therapy of the lungs and bronchioles |
-
1948
- 1948-06-24 US US35059A patent/US2594296A/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1723459A (en) * | 1927-06-29 | 1929-08-06 | Sam L Needle | Medicine for bronchial affections |
US2414918A (en) * | 1941-09-23 | 1947-01-28 | Abramson Harold Alexander | Solutions for the improved nebulization therapy of the lungs and bronchioles |
US2369711A (en) * | 1942-03-17 | 1945-02-20 | Smith Kline French Lab | Medicinal preparation |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2745786A (en) * | 1952-04-02 | 1956-05-15 | Promidel Soc | Method of producing stable theophyllinic aerosols |
US3014844A (en) * | 1957-01-31 | 1961-12-26 | Riker Laboratories Inc | Self-propelling powder dispensing compositions |
US3076745A (en) * | 1958-11-17 | 1963-02-05 | Poultry Service And Res Corp | Antibiotic method for promoting poultry growth |
FR2625677A1 (en) * | 1988-01-07 | 1989-07-13 | Cosnier Alain | Medicinal composition intended for administration in aerosol form |
US5075312A (en) * | 1988-10-27 | 1991-12-24 | Leitman Esther M | Novel anti-micturition composition and method |
US5075314A (en) * | 1988-10-27 | 1991-12-24 | Leitman Esther M | Antimicturition composition and novel method |
US4906641A (en) * | 1988-10-27 | 1990-03-06 | Leitman Esther M | Anti-micturition composition and method |
US20110245270A1 (en) * | 2001-03-23 | 2011-10-06 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
US8377936B2 (en) * | 2001-03-23 | 2013-02-19 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
US20060134008A1 (en) * | 2004-12-16 | 2006-06-22 | Daniel Deaver | Compositions and methods for pulmonary conditions |
EP1824466A2 (en) * | 2004-12-16 | 2007-08-29 | Advanced Inhalation Research, Inc. | Compositions and methods for pulmonary conditions |
EP1824466A4 (en) * | 2004-12-16 | 2008-03-05 | Advanced Inhalation Res Inc | Compositions and methods for pulmonary conditions |
JP2008514648A (en) * | 2004-12-16 | 2008-05-08 | アドバンスト インハレーション リサーチ,インコーポレイテッド | Compositions and methods for lung disease |
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