US2800903A - Injection apparatus - Google Patents

Injection apparatus Download PDF

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Publication number
US2800903A
US2800903A US378508A US37850853A US2800903A US 2800903 A US2800903 A US 2800903A US 378508 A US378508 A US 378508A US 37850853 A US37850853 A US 37850853A US 2800903 A US2800903 A US 2800903A
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Prior art keywords
piston
medicament
sleeve
chamber
ampule
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US378508A
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John H Smoot
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Becton Dickinson and Co
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Becton Dickinson and Co
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Priority claimed from US764817A external-priority patent/US2669230A/en
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Priority to US378508A priority Critical patent/US2800903A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/30Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Definitions

  • a compact assembly is furnished which may be readily employed by relatively unskilled persons to effect an injection of medicament without the necessity of employing a relatively long needle which penetrates those tissues to the requisite depth.
  • the present apparatus permits of the ready injection of dilferent volumes of medicament at the will of the operator; the mechanism being capable of' ready use in connection with the so-called velocity injection technique.
  • Still another object is that of furnishing a mechamsm which will include relatively few parts, each individually simple and rugged in construction, such parts being capable of ready manufacture and assembly to furnish a unitary apparatus capable of use over long periods of time with freedom from all diculties.
  • Fig. 1 is a sectional side View of the apparatus
  • Fig. 2 is a transverse sectional plan view taken lalong the line 2-2 in the direction of the arrows as indicated in Fig. 1;
  • Fig. 3 is a side elevation of one of the elements embodied in the assembly.
  • the numeral 5 indicates the body of the unit which as shown may include a single, main component of tubular configuration and provided adjacent one end with a recess within which a. plug 6 is mounted by, for example, screw threads.
  • This plug deiines a bore constituting a medicament-receiving chamber and within which an ampule 7 of any desired and proper type may be disposed. It is denitely preferred'to einploy such an ampule rather than have the medicament disposed in direct contact with the surfaces defining the chamber.
  • the outer end of the chamber is closed by a nozzle unit 8 which may be mounted by screw threads formed therein and in a recess dened in plug 6.
  • the outer face of nozzle 8 is bulged or convex as indicated at 9 and the adjacent face of plug 6 may be concave or recessed as at 10 to define in conjunction with surface 9, an assembly suitable for contact with the skin surface.
  • Nozzle 8 is formed with a bore leading through to its outer face.
  • a cannula 11 is disposed within this bore and has its inner end of a nature such that it may perforate or otherwise extend into the body of the ampule 7. lf velocity injection is to be resorted to, then at least the outer end of the cannula should be reduced to dene an asphalt ranging for example from .003 to .012".
  • Body 5 is formed with a bore aligned with the chamber of plug 6. Adjacent its lower end, this bore may be formed with a laterally extending venting passage 13.
  • a plunger 14 is projectible through this bore and into the chamber of plug 6. With an ampule 7 within the cham-'- ber the plunger Will serve to cooperate with the latter to assure a discharge of medicament from that space and out through the passage of nozzle 3 or any equivalent structure employed at that point.
  • Piston 12 is power projected in a manner hereinafter brought out and is continued in the form of a rod 15 connected to it in any suitable manner as, for example, by screw threads.
  • a washer 16 Conveniently disposed at the point of juncture of the piston and rod Ais a washer 16.
  • the diameter of the latter is suliiciently small so that it may be freely movable axially of the assembly and within the bore or enlarged recessed Vportion formed in the upper' end of body 5.
  • a cap 17 closes the outer end of this bore.
  • ⁇ A powering mechanism such as a spring 18 is interposed between cap 17 and washer 16. Therefore, with cap 17 secured against movement with respect to body 5,A it follows that spring 18 will exert an outward or downward pressure on the washer 16 and piston 14. In this manner, the piston will be power projected.
  • Cap 17 is formed with an opening through which a sleeve 19 slidably projects.
  • the upper end of the latter conveniently terminates in a handle portion 20 lying beyond cap 17.
  • the inner end of sleeve 19 may be inturned as at 21.
  • the upper or inner end of rod 15 terminates in an enlarged head 22, the diameter of which is such that it will engage with the surfaces of end portion 21.
  • the outer face or" sleeve 19 provides indicia at 23. This indicia may be exposed above the upper face of cap 16 and include any desirable number of graduations indicative of volumetric capacity. As illustrated, these graduations embrace the marks M1, :'/s and 1/2 and in each instance indicate fractions of a cubic centimeter.
  • piston 14 may be formed with a corresponding number of detent or shoulder portions 24. Additionally, it may be formed with a somewhat spaced shoulder or detent portion 25.
  • a movable trigger or latch mechanism is furnished.
  • this element includes a transversely disposed and shiftable plate 26. This plate is formed with a central opening 27 yof an area such that plunger 14 may pass therethrough. The plate is mounted upon a rod 28 which may be spring-pressed as at 29 and provided with an actuator or trigger portion 30 projecting beyond the side face of housing or body 5. Normally, and under the influence of spring 29, plate 26 will occupy a position such that it underlies one of the shoulders 24 or 25.
  • opening 27 will assume a position such as has been indicated in dash lines in Fig. 2. Under these circumstances, the edge zone of the plate opening will. completely clear the latch portions or detents and plunger' 14, together with rod 15, will be free to project under the inuence of spring 13.
  • plate 26 With the trigger mechanism not engaged. by the operators finger, plate 26 will, under these circumstances, override one or more of the stops or detents 24 and come to rest below the one corresponding to the elected dosage. So arranged, it will latch against the elected surface to prevent, a ⁇ projection of piston 14 until such time as plate 26 is shifted by actuator or trigger 30.
  • nozzle 9 will be pressed against the adjacent skin surface. Lateral movement of the apparatus will be prevented incident toY the surface configuration of this nozzle especially in conjunction with the relatively sharp edges defined by the edge surfaces of plug 6 due to the concavity or recess violence the upper end of ampule 7 or equivalent, rnedicament-containing element.
  • communication will have been established be- Y tween the interior of the ampule and the bore of passage 11. Therefore as the plunger assembly cooperates with the medicament chamber, the liquid within the latter will be expelled through the nozzle bore.
  • the operator may retract sleeve 19 and the plunger assembly to a point where the detent plate 26 engages Vstop 25.
  • nozzle 8 may be dismounted and the'ampule which has been collapsed coincident with the injection, can readily be removed from the medicament chamber. Thereupon a new ampule'is positioned within that Vchamber and the entire cycleV of operation completed.
  • the piston assembly will Venter the medicament chamber with greater or lesser force. As aforebrought out this will permit of larger or smaller volumes of liquid being expelled from the charnber at the necessary pressures. Additionally, it willpermit of that liquid medicament being injected into the 4y tissues to a greater or lesser depth. To this end a shorter ampule may be used within the chamber. Also, the indicia 23 may be altered to indicate the force with which the piston will act against the ampule and/ or the general depth of injection and pattern of dispersion which may be anticipated.
  • An injectionk apparatus including in combination a body providing at one end a medicament-receiving chamber having a discharge opening, a power-driven piston reciprocal Within said body to expel medicament fromsaid chamber, a latch movably mounted by said body to maintain said piston in a retracted position, av sleeve slidably mounted by said body to extend rearwardly of the same,. said sleeve engaging with said piston adjacent its inner end to retract said piston, said sleeve being there'- upon projectible into said body to be housed thereink and' saidI piston, duringsuch projection, remaining in retracted position as a consequence of the operation of said latch.
  • An injection apparatus including in combination' a body providing at one end a medicament-receiving chamber having a discharge opening, a power-driven piston reciprocal within saidy body to expel medicament from said chamber, a latch movably mounted by said body toV mounted' by said body to be projected beyond the rear end of the same, an inturned portion carried by said tube, a head atV the inner end of said piston, said inturned porti-on slidably engaging said piston and-.abutting said head to thereupon retract said piston/in unison with said sleeve and a handle secured to the outer end of said sleeve.
  • An injectionV apparatus includingV in combination a body providing at one end a medicament-receiving chamber having a discharge opening, a power-driven piston re ciprocal within said body to expel medicament fromv said chamber, a latch movably mounted by said body to maintain said pistonV in a retracted position, a tubeY slidably mounted by said body adjacent its rear end and being extendible beyond that end, meansl for connecting said sleeve and piston for slidable movement with respect to each otherl and: thereupon forv movement in unison, in-

Description

July 30 1957 J. H. sMooT 2,800,903
INJECTION APPARATUS Original Filed July 30, 1947 INVENTOR ffice Utl-feti .States @wat INJECTION APPARATUS John H. Smoot, Darien, Conn., assignor to Becton, Dickinson and Company, Rutherford, N. J., a corporation of New Jersey 3 Claims. (Ci. 12S-173) This invention relates to a structurally and functionally improved injection apparatus;l the present apphcation being a division of my prior application for patent on Injection Apparatus now issued under No. 2,669,230 on February 16, 1954. A
By means of the present teachings, a compact assembly is furnished which may be readily employed by relatively unskilled persons to effect an injection of medicament without the necessity of employing a relatively long needle which penetrates those tissues to the requisite depth.
Moreover, the present apparatus permits of the ready injection of dilferent volumes of medicament at the will of the operator; the mechanism being capable of' ready use in connection with the so-called velocity injection technique.
Still another object is that of furnishing a mechamsm which will include relatively few parts, each individually simple and rugged in construction, such parts being capable of ready manufacture and assembly to furnish a unitary apparatus capable of use over long periods of time with freedom from all diculties.
With these and other objects in mind, reference is had to the attached sheet of drawings illustrating one practical embodiment of the invention and in which:
Fig. 1 is a sectional side View of the apparatus;
Fig. 2 is a transverse sectional plan view taken lalong the line 2-2 in the direction of the arrows as indicated in Fig. 1; and
Fig. 3 is a side elevation of one of the elements embodied in the assembly.
Referring primarily to Fig. l, the numeral 5 indicates the body of the unit which as shown may include a single, main component of tubular configuration and provided adjacent one end with a recess within which a. plug 6 is mounted by, for example, screw threads. l This plug deiines a bore constituting a medicament-receiving chamber and within which an ampule 7 of any desired and proper type may be disposed. It is denitely preferred'to einploy such an ampule rather than have the medicament disposed in direct contact with the surfaces defining the chamber. The outer end of the chamber is closed by a nozzle unit 8 which may be mounted by screw threads formed therein and in a recess dened in plug 6. Preferably the outer face of nozzle 8 is bulged or convex as indicated at 9 and the adjacent face of plug 6 may be concave or recessed as at 10 to define in conjunction with surface 9, an assembly suitable for contact with the skin surface. Nozzle 8 is formed with a bore leading through to its outer face. A cannula 11 is disposed within this bore and has its inner end of a nature such that it may perforate or otherwise extend into the body of the ampule 7. lf velocity injection is to be resorted to, then at least the outer end of the cannula should be reduced to dene an orice ranging for example from .003 to .012".
Body 5 is formed with a bore aligned with the chamber of plug 6. Adjacent its lower end, this bore may be formed with a laterally extending venting passage 13. A plunger 14 is projectible through this bore and into the chamber of plug 6. With an ampule 7 within the cham-'- ber the plunger Will serve to cooperate with the latter to assure a discharge of medicament from that space and out through the passage of nozzle 3 or any equivalent structure employed at that point. Piston 12 is power projected in a manner hereinafter brought out and is continued in the form of a rod 15 connected to it in any suitable manner as, for example, by screw threads.
Conveniently disposed at the point of juncture of the piston and rod Ais a washer 16. The diameter of the latter, as shown, is suliiciently small so that it may be freely movable axially of the assembly and within the bore or enlarged recessed Vportion formed in the upper' end of body 5. A cap 17 closes the outer end of this bore. `A powering mechanism such as a spring 18 is interposed between cap 17 and washer 16. Therefore, with cap 17 secured against movement with respect to body 5,A it follows that spring 18 will exert an outward or downward pressure on the washer 16 and piston 14. In this manner, the piston will be power projected. v
Cap 17 is formed with an opening through which a sleeve 19 slidably projects. The upper end of the latter conveniently terminates in a handle portion 20 lying beyond cap 17. The inner end of sleeve 19 may be inturned as at 21. The upper or inner end of rod 15 terminates in an enlarged head 22, the diameter of which is such that it will engage with the surfaces of end portion 21. Conveniently as in Fig. 3, the outer face or" sleeve 19 provides indicia at 23. This indicia may be exposed above the upper face of cap 16 and include any desirable number of graduations indicative of volumetric capacity. As illustrated, these graduations embrace the marks M1, :'/s and 1/2 and in each instance indicate fractions of a cubic centimeter.
As shown, the rear end of piston 14 may be formed with a corresponding number of detent or shoulder portions 24. Additionally, it may be formed with a somewhat spaced shoulder or detent portion 25. To cooperate with these portions, a movable trigger or latch mechanism is furnished. Conveniently, and as shown in detail in Fig. 2, this element includes a transversely disposed and shiftable plate 26. This plate is formed with a central opening 27 yof an area such that plunger 14 may pass therethrough. The plate is mounted upon a rod 28 which may be spring-pressed as at 29 and provided with an actuator or trigger portion 30 projecting beyond the side face of housing or body 5. Normally, and under the influence of spring 29, plate 26 will occupy a position such that it underlies one of the shoulders 24 or 25. However, when actuator 30 is pressed inwardly against the action of this spring, opening 27 will assume a position such as has been indicated in dash lines in Fig. 2. Under these circumstances, the edge zone of the plate opening will. completely clear the latch portions or detents and plunger' 14, together with rod 15, will be free to project under the inuence of spring 13.
ln operation, it will be understood that a user will grasp actuator or handle 20 and retract the same. With such retraction, the inturned end portion of sleeve 19 will engage head 22. This will cause rod 15 and piston 14 to be retracted to a point where at least detent or stop portion 25 rides past the upper surface of plate 26. Under these circumstances, piston 14 will be clear of the medicament chamber defined within plug 6. Therefore, if nozzle 8 is dismouiited, an ampule 7 may be disposed within this chamber or the latter may otherwise be suitably filled with medicament. The fact that piston 14 has been retracted to a point rendering the entire interior of the chamber accessible will be indicated by, for ex` ample, the load term of indicia 23 being visible above cap 17. According to the amount of medicament which Patented 'July 30, 1957 is to be injected, a more or less forceful projection of piston 1'4` should occur. Therefore, the operator will observe the area of sleeve 19 above cap 17 and according to the. elected dosage, will interrupt further retraction of the actuator 20 and sleeve. 19 in line with theindication 23 whichcorresponds to the volume Yof liquid to be discharged under elective conditions. Y
With the trigger mechanism not engaged. by the operators finger, plate 26 will, under these circumstances, override one or more of the stops or detents 24 and come to rest below the one corresponding to the elected dosage. So arranged, it will latch against the elected surface to prevent, a` projection of piston 14 until such time as plate 26 is shifted by actuator or trigger 30.
The site of injection having been selected, nozzle 9 will be pressed against the adjacent skin surface. Lateral movement of the apparatus will be prevented incident toY the surface configuration of this nozzle especially in conjunction with the relatively sharp edges defined by the edge surfaces of plug 6 due to the concavity or recess violence the upper end of ampule 7 or equivalent, rnedicament-containing element. During the positioning of nozzle 8, communication will have been established be- Y tween the interior of the ampule and the bore of passage 11. Therefore as the plunger assembly cooperates with the medicament chamber, the liquid within the latter will be expelled through the nozzle bore. lf at least the outer end of that bore be constricted, then aY stream of suiciently reduced diameter will be projected suchl that the liquid will move at skin-penetrating velocities so that no tissue-piercing needle will have to be employed. According to the setting of the plunger as established by the retraction of the actuator and sleeve, the desired dosage will be injected.
After completion of the injection, the operator, byv engaging actuator'ZO, may retract sleeve 19 and the plunger assembly to a point where the detent plate 26 engages Vstop 25. Under these conditions, nozzle 8 may be dismounted and the'ampule which has been collapsed coincident with the injection, can readily be removed from the medicament chamber. Thereupon a new ampule'is positioned within that Vchamber and the entire cycleV of operation completed.
As a consequence of the dilerent positions to which the piston assembly may be retracted, that assembly will Venter the medicament chamber with greater or lesser force. As aforebrought out this will permit of larger or smaller volumes of liquid being expelled from the charnber at the necessary pressures. Additionally, it willpermit of that liquid medicament being injected into the 4y tissues to a greater or lesser depth. To this end a shorter ampule may be used within the chamber. Also, the indicia 23 may be altered to indicate the force with which the piston will act against the ampule and/ or the general depth of injection and pattern of dispersion which may be anticipated.
Thus, among others, the several objects of the invention as specically aforenoted are` accomplished. Obviously numerous changes. in construction andy rearrangement of the parts might be resorted to Without departing fromthe spirit of the invention as defined by the claims.
I claim:
l. An injectionk apparatus including in combination a body providing at one end a medicament-receiving chamber having a discharge opening, a power-driven piston reciprocal Within said body to expel medicament fromsaid chamber, a latch movably mounted by said body to maintain said piston in a retracted position, av sleeve slidably mounted by said body to extend rearwardly of the same,. said sleeve engaging with said piston adjacent its inner end to retract said piston, said sleeve being there'- upon projectible into said body to be housed thereink and' saidI piston, duringsuch projection, remaining in retracted position as a consequence of the operation of said latch.
2. An injection apparatus including in combination' a body providing at one end a medicament-receiving chamber having a discharge opening, a power-driven piston reciprocal within saidy body to expel medicament from said chamber, a latch movably mounted by said body toV mounted' by said body to be projected beyond the rear end of the same, an inturned portion carried by said tube, a head atV the inner end of said piston, said inturned porti-on slidably engaging said piston and-.abutting said head to thereupon retract said piston/in unison with said sleeve and a handle secured to the outer end of said sleeve.
3. An injectionV apparatus includingV in combination a body providing at one end a medicament-receiving chamber having a discharge opening, a power-driven piston re ciprocal within said body to expel medicament fromv said chamber, a latch movably mounted by said body to maintain said pistonV in a retracted position, a tubeY slidably mounted by said body adjacent its rear end and being extendible beyond that end, meansl for connecting said sleeve and piston for slidable movement with respect to each otherl and: thereupon forv movement in unison, in-
dicia upon the surface of said sleeve and exposable'beyond the body as said sleeve is retracted, ,said indicia indicating the degree of retraction of said piston by said sleeve and a series of latch portions on saidv piston andk engageable .by said latch, said latch portions being spacedY in conformity with such indicia.
References Cited in the file of this patent UNTTED STATES PATENTS Smoot Feb. 16, 195-4
US378508A 1947-07-30 1953-09-04 Injection apparatus Expired - Lifetime US2800903A (en)

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Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3494358A (en) * 1967-12-18 1970-02-10 Verne Fehlis Self-triggered veterinary inoculating device
US3788315A (en) * 1971-04-20 1974-01-29 S Laurens Disposable cutaneous transjector
US3789844A (en) * 1971-04-16 1974-02-05 A Burges Foil sealed syringe
EP0063340A1 (en) * 1981-04-16 1982-10-27 Hoechst Aktiengesellschaft Needleless injection apparatus
US4518385A (en) * 1983-06-13 1985-05-21 Preci-Tech Ltd. Disposable syringe for needleless injector
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
WO1988009677A1 (en) * 1987-06-08 1988-12-15 Antonio Nicholas F D Hypodermic fluid dispenser
US4850967A (en) * 1986-06-17 1989-07-25 Sicim Spa Portable endermic injector
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US5080648A (en) * 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
WO1994007554A1 (en) * 1992-09-28 1994-04-14 Equidyne Systems, Incorporated Hypodermic jet injector
US5569189A (en) * 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5899879A (en) * 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
US6558348B2 (en) 2000-04-07 2003-05-06 Equidyne Systems, Inc. Low cost disposable needleless injector system for variable and fixed dose applications
US20030097093A1 (en) * 2000-05-30 2003-05-22 Alain Navelier Needleless syringe with membrane isolating a multiple duct injector
US20030191449A1 (en) * 1999-08-05 2003-10-09 Kensey Nash Corporation Systems for delivering agents into targeted tissue of a living being
US20060106333A1 (en) * 1999-10-11 2006-05-18 Leon Nanthaniel J Universal protector cap with auto-disable features for needle-free injectors
US20070027428A1 (en) * 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US20070118094A1 (en) * 2005-05-03 2007-05-24 John Bingham Needle-less injector and method of fluid delivery
US20070191762A1 (en) * 2002-05-30 2007-08-16 Kerry Quinn Needleless injector and ampule system
US20080281261A1 (en) * 2005-05-03 2008-11-13 Genesis Medical Technologies, Inc. Needle-less injector
US20110015576A1 (en) * 2009-06-01 2011-01-20 Sanofi-Aventis Deutschland Gmbh Medicament identification system for multi-dose injection devices
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
US9433735B2 (en) 2011-12-13 2016-09-06 Pharmajet Inc. Needle-free intradermal injection device

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US98478A (en) * 1870-01-04 Improvement in automatic vaccinating-instrdments
US2295849A (en) * 1940-10-25 1942-09-15 Gustave L Kayden Attachment for hypodermic syringes
US2380534A (en) * 1941-04-26 1945-07-31 Marshall L Lockhart Hypodermic injector
US2669230A (en) * 1947-07-30 1954-02-16 Becton Dickinson Co Injection apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US98478A (en) * 1870-01-04 Improvement in automatic vaccinating-instrdments
US2295849A (en) * 1940-10-25 1942-09-15 Gustave L Kayden Attachment for hypodermic syringes
US2380534A (en) * 1941-04-26 1945-07-31 Marshall L Lockhart Hypodermic injector
US2669230A (en) * 1947-07-30 1954-02-16 Becton Dickinson Co Injection apparatus

Cited By (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3494358A (en) * 1967-12-18 1970-02-10 Verne Fehlis Self-triggered veterinary inoculating device
US3789844A (en) * 1971-04-16 1974-02-05 A Burges Foil sealed syringe
US3788315A (en) * 1971-04-20 1974-01-29 S Laurens Disposable cutaneous transjector
EP0063340A1 (en) * 1981-04-16 1982-10-27 Hoechst Aktiengesellschaft Needleless injection apparatus
US4518385A (en) * 1983-06-13 1985-05-21 Preci-Tech Ltd. Disposable syringe for needleless injector
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
US4850967A (en) * 1986-06-17 1989-07-25 Sicim Spa Portable endermic injector
WO1988009677A1 (en) * 1987-06-08 1988-12-15 Antonio Nicholas F D Hypodermic fluid dispenser
US5080648A (en) * 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
US5318522A (en) * 1987-06-08 1994-06-07 Antonio Nicholas F D Hypodermic fluid dispenser
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US5569189A (en) * 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5704911A (en) * 1992-09-28 1998-01-06 Equidyne Systems, Inc. Needleless hypodermic jet injector
WO1994007554A1 (en) * 1992-09-28 1994-04-14 Equidyne Systems, Incorporated Hypodermic jet injector
US5499972A (en) * 1992-09-28 1996-03-19 Equidyne Systems, Inc. Hypodermic jet injector
US5919159A (en) * 1995-01-09 1999-07-06 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5846233A (en) * 1995-01-09 1998-12-08 Medi-Ject Corporation Coupling device for medical injection system
US5891085A (en) * 1995-01-09 1999-04-06 Medi-Ject Corporation Nozzle assembly with lost motion connection for medical injector assembly
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
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