US2842126A - Syringe assembly - Google Patents

Syringe assembly Download PDF

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Publication number
US2842126A
US2842126A US416606A US41660654A US2842126A US 2842126 A US2842126 A US 2842126A US 416606 A US416606 A US 416606A US 41660654 A US41660654 A US 41660654A US 2842126 A US2842126 A US 2842126A
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barrel
cap
needle
plunger
parts
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US416606A
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Frank E Brown
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/348Constructions for connecting the needle, e.g. to syringe nozzle or needle hub snap lock, i.e. upon axial displacement of needle assembly

Definitions

  • Fig. 2 is a similar view taken along the line 2--2 in the direction of the arrows as :indicated ⁇ in Fig. ,1; p
  • Figs. 3 and 4 are transverse sectional views taken along the lines 3 3 and 4-4, respectively, in the direction t of the arrows as also indicated in Fig. l;
  • Fig. 5 shows a sectional side view of an alternative form of apparatus with the parts arranged in an initial or inoperative condition
  • Fig. 6 is a transverse sectional view taken along the line 6 6 in the direction of the arrows as indicated in Fig. 5;
  • Fig. 7 is a view similar to Fig. 5 but illustrating the parts in shifted condition, such that they are ready to perform an injection;
  • Fig. 8 is a further sectional side view of an alternative form of apparatus
  • Fig. 9 is a transverse sectional view taken along the line 9--9 in the direction of the arrows as indicated in Fig. 8.
  • the numeral 10 indicates a tube or barrel formed of any suitable material such as glass and provided adjacent its opposite ends with llanges 11 and 12. As shown especially in Figs. 3 and 4, these anges are interrupted throughout certain portions of the circumference of the barrel so that at diametrically opposite points the anges are, in fact, reduced or non-existent, while at intervening points they provide outstanding ears or mounting portions.
  • Adjacent the rear end of the barrel a plunger is provided in the form of a piston 13 which may be shiftedlengthwise of the barrel bore to express the medicament therefrom.
  • a closure member 14 which provides a perforable diaphragm portion 15 and maintains the medicament against escape.
  • the plunger or piston 13 and the closure member 14 ⁇ are formed of rubber of natural or synthetic types.
  • a needle 16 is included in the assembly and has its opposite ends pointed. This needle is suitably secured lie in ⁇ the positions shown in Figs. 1 and 4 to 2,842,126 "Patented July 8, 1958 against movement with respect to a cap 17.
  • This cap may be formed of metal or plastic. It is retained in position by having rearwardly and inwardly extending portions 18jinengagement with the outer edges and inner faces oflange ,12. It mayfobviously be applied to that llangefby bringing these into general alignment with the interruptions of the flange. Thereafter it is :shifted axially towards barrel 10 so that the parts 18 overlap the plane ofange 12. Thereupon, by effecting relative rotation of thisf-eap with respect to the barrel, parts 18 will prevent an accidental separation of the elements.
  • an actuator forthe plunger is conveniently provided Vby employinga cap 19 which has forwardly andinwardly extending parts 20 to overlap the llange por- .tions 11.
  • This cap slidably mounts a plunger 21, the
  • plunger 21 may terminate in an actuating or thumb-engaging portion 22'. ⁇ It may also be provided with a bore 23.
  • the actuator may be coupled to or detached from ⁇ the rear end of the barrel by simply moving the l parts in an axial direction and rotating the cap 19 with respect to the barrel so as to cause the retaining portions 20 teclear or engage with flange 11.
  • the bore of barrel 10 is filled with a medicament solution and closed by; elements 13 and 14.
  • the plunger 21 conveniently houses the outer end of needle 16 although this isialmatter ofchoice.
  • the cap 19 of the actuator assembly is attached to the rear end of the barrel.
  • Cap 17 is coupled to the opposite barrel end.
  • the inner end of the needle 16 perforates diaphragm portion 15 to establish communication between the interior ofthe barrel and the bore of the needle.
  • the barrel provides an external circumferential groove which embraces its outer surface between flanges 11 and 12 and which groove extends through to the end portions as defined by these anges.
  • the closure member 14 insures against contamination of the medicament under all circumstances prior to the mounting of the needle assembly.
  • the cap 17 furnishes a connector member, the inner surface of which provides a retaining means which engages the outer end of closure or stopper member 14.
  • the rearwardly and inwardly extending parts 18 provide retaining means engaging within the groove between flange portions 11 and 12 and serve to hold the connector member fixed on the barrel. When in applied position the hypodermic needle extends through the closure member and axially beyond the forward syringe end.
  • a barrel 24 is furnished which at one end is provided with a piston or plunger 25 similar to plunger 13.
  • This piston may also be furnished with a coupling element such as a screw threaded stern 26 for engagement with a correspondingly threaded actuator (not shown) by means of which it may be projected and retracted.
  • the barrel 24 is flanged outwardly adjacent its opposite ends as at 27. m
  • a closure member such as a rubber stopper 28 closes the forward end of the barrel bore and has its head portion overlapping surfaces of the adjacent ange 27 so that accidental inward shifting of this member is precluded.
  • a connector member conveniently in the form of a cap 29 carries a double-ended needle 30. Both the barrel and cap 29 may be formed of material such that they are capable of being indented; the indentations of'barrel 24 having been indicated at 31 and the indentations of the cap skirt being indicated at 32. Especially the material of the cap will be such that it embodies resiliency.
  • the p arts in their initial position mayV be arranged as shown in Fig. in which the inner needle end has not perforated the diaphragm of the ⁇ closure member.
  • the inner needle end has not perforated the diaphragm of the ⁇ closure member.
  • it will ride rearwardlyover the same in telescoping relationship until lthe projections provided by indentations 32 enter ⁇ into Athe recesses furnished by indentations 31 as shown inFig. 7.
  • any suitable form of actuator may be coupled with the plunger or piston 25. The lattermay be shifted rearwardly to aspirate the syringe and alsopro- ⁇ jected to cause an expulsion of medicament through the bore of the cannula.
  • a barrel 33 may again be formed of any suitable material and have the rear end of its bore closed by a piston plunger 34. Its forward end is sealed by a closure 35 corresponding to closures 14 andy 28.
  • the opposite endy edges of the barrelV areanged outwardly as at 36 to thus define in common with the structure of the preceding figures an external circumferential circular groove on the outer face of the Vbarrel and extending through tothe end portions of the same.
  • Cap 37 again provided of any suitable material, mounts needle 38 and furnishes a connector member corresponding to caps 17 and 29. ⁇
  • its inner face will furnish a retaining surface engaging with the outer face of closure member 3S.
  • Its skirt will be retained against displacement with respect to the barrel by employ: ing, for example, a ring 39 between the inner surface of this skirt and the outer face of the barrel.
  • this/ring' engages withinthe groove on the outer barrel surface.
  • the retaining ring is placed over the barrel and pressed into contact with the inner face of the skirt cap by using afsuitable cement or other procedure calculated to prevent the detachment of the ring from the cap.
  • a syringe assembly including in combination a barrel, a closure at one end of said barrel, a plunger at the opposite end of the same, outwardlyextending flanges forming a part of said barrel adjacent its ends, caps, an actuating stem slidably carried by one of said caps, a doubleended needle carried by the second of same, flanges in theform ofspaced wing portionshat diametrically opposite points in said caps and shiftble to positionsoverlying and engaging yagainst saidbarrel flanges to retain said4 caps against movement with respectz to said barrel.

Description

July 8, 1958 F. E. BROWN SYRINGE ASSEMBLY Filed March 1e, 1954 United States Patent() 2,842,126 sjYRustGE `laissais/unir 'y E. Brown,` llurbank, Calif., assignor tov Frederick M. Turnbull, Los Angeles, Calif.` l Applicator] March V16,` 1954,'sma`1 N0.`4i6,6o6 i ciainrf (ci. izszls) This invention relatesfto a'structurally and functionally improved syringe assembly 'of the hypodermic type. f `It is an object of theinve'ntion to furnish a readily operable mechanism lwhich may preferably have a onetime use, although its parts can be `cleaned and sterilized so that it can again be used in subsequent injections.
An additional object is that "of furnishing a syringe which will `include relatively few units, cach individually rugged andlzsimple `in design, suh units being capable of ,ready manufacture and assemblage toy furnish a' mechanism which may be stored in filled `condition for indefinite periods of time without the` stability of the medicament being affected. e y t y l With these and other objects in mind,'reference is had to theattac'hed sheet of drawings illustrating practical embodiments ofthe invention `and in which: t t Fig. 1 `is a sectional side view of a hypodermicsyringe assembly; i
Fig. 2 is a similar view taken along the line 2--2 in the direction of the arrows as :indicated `in Fig. ,1; p
Figs. 3 and 4 are transverse sectional views taken along the lines 3 3 and 4-4, respectively, in the direction t of the arrows as also indicated in Fig. l;
Fig. 5 shows a sectional side view of an alternative form of apparatus with the parts arranged in an initial or inoperative condition;
Fig. 6 is a transverse sectional view taken along the line 6 6 in the direction of the arrows as indicated in Fig. 5;
Fig. 7 is a view similar to Fig. 5 but illustrating the parts in shifted condition, such that they are ready to perform an injection;
Fig. 8 is a further sectional side view of an alternative form of apparatus, 4and Fig. 9 is a transverse sectional view taken along the line 9--9 in the direction of the arrows as indicated in Fig. 8.
Referring primarily to Figs. 1 to 4, the numeral 10 indicates a tube or barrel formed of any suitable material such as glass and provided adjacent its opposite ends with llanges 11 and 12. As shown especially in Figs. 3 and 4, these anges are interrupted throughout certain portions of the circumference of the barrel so that at diametrically opposite points the anges are, in fact, reduced or non-existent, while at intervening points they provide outstanding ears or mounting portions. Adjacent the rear end of the barrel a plunger is provided in the form of a piston 13 which may be shiftedlengthwise of the barrel bore to express the medicament therefrom. At its opposite or outer end the barrel mounts a closure member 14 which provides a perforable diaphragm portion 15 and maintains the medicament against escape. Conveniently the plunger or piston 13 and the closure member 14` are formed of rubber of natural or synthetic types.
A needle 16 is included in the assembly and has its opposite ends pointed. This needle is suitably secured lie in` the positions shown in Figs. 1 and 4 to 2,842,126 "Patented July 8, 1958 against movement with respect to a cap 17. This cap may be formed of metal or plastic. It is retained in position by having rearwardly and inwardly extending portions 18jinengagement with the outer edges and inner faces oflange ,12. It mayfobviously be applied to that llangefby bringing these into general alignment with the interruptions of the flange. Thereafter it is :shifted axially towards barrel 10 so that the parts 18 overlap the plane ofange 12. Thereupon, by effecting relative rotation of thisf-eap with respect to the barrel, parts 18 will prevent an accidental separation of the elements.
Similarly an actuator forthe plunger is conveniently provided Vby employinga cap 19 which has forwardly andinwardly extending parts 20 to overlap the llange por- .tions 11. This cap slidably mounts a plunger 21, the
diameter of which is suiciently reduced so that itmay enter the `bore of barrel 10. At its outer end, plunger 21 may terminate in an actuating or thumb-engaging portion 22'.` It may also be provided with a bore 23.
t This `bore is capable of receiving the needle prior to the assembly of the parts. So housed the needle will be completely enclosed and protected against contamination. As is apparent, the actuator may be coupled to or detached from` the rear end of the barrel by simply moving the l parts in an axial direction and rotating the cap 19 with respect to the barrel so as to cause the retaining portions 20 teclear or engage with flange 11.
- `It will be* obvious that the parts of the assembly as Ishown in Figs. l to 4 may be cleaned and sterilized. The
bore of barrel 10 is filled with a medicament solution and closed by; elements 13 and 14. The plunger 21 conveniently houses the outer end of needle 16 although this isialmatter ofchoice. In any event, when is is desired to useltthe apparatus, the cap 19 of the actuator assembly is attached to the rear end of the barrel. Cap 17 is coupled to the opposite barrel end. As it is so coupled the inner end of the needle 16 perforates diaphragm portion 15 to establish communication between the interior ofthe barrel and the bore of the needle. Thus, the barrel provides an external circumferential groove which embraces its outer surface between flanges 11 and 12 and which groove extends through to the end portions as defined by these anges. The closure member 14 insures against contamination of the medicament under all circumstances prior to the mounting of the needle assembly. The cap 17 furnishes a connector member, the inner surface of which provides a retaining means which engages the outer end of closure or stopper member 14. The rearwardly and inwardly extending parts 18 provide retaining means engaging within the groove between flange portions 11 and 12 and serve to hold the connector member fixed on the barrel. When in applied position the hypodermic needle extends through the closure member and axially beyond the forward syringe end.
Similarly in the structure shown in Figs. 5 6 and 7 a barrel 24 is furnished which at one end is provided with a piston or plunger 25 similar to plunger 13. This piston may also be furnished with a coupling element such as a screw threaded stern 26 for engagement with a correspondingly threaded actuator (not shown) by means of which it may be projected and retracted. The barrel 24 is flanged outwardly adjacent its opposite ends as at 27. m
A closure member such as a rubber stopper 28 closes the forward end of the barrel bore and has its head portion overlapping surfaces of the adjacent ange 27 so that accidental inward shifting of this member is precluded. A connector member conveniently in the form of a cap 29 carries a double-ended needle 30. Both the barrel and cap 29 may be formed of material such that they are capable of being indented; the indentations of'barrel 24 having been indicated at 31 and the indentations of the cap skirt being indicated at 32. Especially the material of the cap will be such that it embodies resiliency.
Accordingly, the p arts in their initial position mayV be arranged as shown in Fig. in which the inner needle end has not perforated the diaphragm of the `closure member. However, by exerting pressure in a direction axial ofthis cap with respect to the barrel, it will ride rearwardlyover the same in telescoping relationship until lthe projections provided by indentations 32 enter` into Athe recesses furnished by indentations 31 as shown inFig. 7. In this manner the cap is prevented from being accidentally withdrawn or otherwise shifting over theouter end of the barrel. When the parts are in the positions shown in Fig. 7, any suitable form of actuator may be coupled with the plunger or piston 25. The lattermay be shifted rearwardly to aspirate the syringe and alsopro-` jected to cause an expulsion of medicament through the bore of the cannula.
`Finally, as in Fig. 8, a barrel 33 may again be formed of any suitable material and have the rear end of its bore closed by a piston plunger 34. Its forward end is sealed by a closure 35 corresponding to closures 14 andy 28. The opposite endy edges of the barrelV areanged outwardly as at 36 to thus define in common with the structure of the preceding figures an external circumferential circular groove on the outer face of the Vbarrel and extending through tothe end portions of the same. Cap 37, again provided of any suitable material, mounts needle 38 and furnishes a connector member corresponding to caps 17 and 29.` Thus, when it is shifted to the position indicated in dot and dash lines, its inner face will furnish a retaining surface engaging with the outer face of closure member 3S. Its skirt will be retained against displacement with respect to the barrel by employ: ing, for example, a ring 39 between the inner surface of this skirt and the outer face of the barrel.- Obviously, as the parts are slid axially with respect to eachl other,
this/ring' engages withinthe groove on the outer barrel surface. As is apparent, the retaining ring is placed over the barrel and pressed into contact with the inner face of the skirt cap by using afsuitable cement or other procedure calculated to prevent the detachment of the ring from the cap.
Thus, among others, the several objects of the invention as specifically aforenoted are achieved. Obviously numerous changes in construction and re-arrangements of the parts might be resorted to without departing from the spirit of the invention as deiined `by the claim.
I claim: v A,
A syringe assembly including in combination a barrel, a closure at one end of said barrel, a plunger at the opposite end of the same, outwardlyextending flanges forming a part of said barrel adjacent its ends, caps, an actuating stem slidably carried by one of said caps, a doubleended needle carried by the second of same, flanges in theform ofspaced wing portionshat diametrically opposite points in said caps and shiftble to positionsoverlying and engaging yagainst saidbarrel flanges to retain said4 caps against movement with respectz to said barrel.
` kReferences Citedin the yfill@ Qf `this patent- UNITED. STATES PATENTS.
US416606A 1954-03-16 1954-03-16 Syringe assembly Expired - Lifetime US2842126A (en)

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Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3023751A (en) * 1957-07-02 1962-03-06 Seymour R Lipsky Injection apparatus and ampule
US3074541A (en) * 1959-10-13 1963-01-22 Brunswick Corp Medicinal vial and needle assembly
US3556099A (en) * 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
FR2208683A1 (en) * 1972-12-05 1974-06-28 Mpl Inc Medical syringe with plastics finger grips - fitted on polypropylene sleeve over end of glass tube
US4291695A (en) * 1976-04-05 1981-09-29 Duphar International Research B.V. Disposable injection syringe
US4568336A (en) * 1984-04-26 1986-02-04 Microbiological Applications, Inc. Pre-filled hypodermic syringes
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US5002538A (en) * 1988-10-25 1991-03-26 Johnson Johnnie M Syringe adapter and method
US5240323A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with extendable agitator bellows
US5240322A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5352036A (en) * 1992-09-23 1994-10-04 Habley Medical Technology Corporation Method for mixing and dispensing a liquid pharmaceutical with a miscible component
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
US6206858B1 (en) * 1996-12-16 2001-03-27 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Blunt tip cannula with access pin
JP2003199827A (en) * 2001-12-28 2003-07-15 Terumo Corp Syringe
US20050113754A1 (en) * 2003-11-25 2005-05-26 Cowan Kevin P. Syringes, syringe interfaces and syringe plungers for use with medical injectors
US20080015519A1 (en) * 2002-07-03 2008-01-17 Novo Nordisk A/S Needle Mounting System And A Method For Mounting A Needle Assembly
CN100502968C (en) * 2002-07-03 2009-06-24 诺沃挪第克公司 A needle mounting system and a method for mounting a needle assembly
US20100256486A1 (en) * 2000-07-10 2010-10-07 Medrad, Inc. Syringes for Medical Injector Systems
WO2011051366A3 (en) * 2009-10-30 2011-06-30 Sanofi-Aventis Deutschland Gmbh Drug delivery device
USD675316S1 (en) 2007-08-22 2013-01-29 Novo Nordisk A/S Needle hub
US20160199582A1 (en) * 2011-10-14 2016-07-14 Amgen Inc. Method of assembling and filling a drug delivery device
US9480797B1 (en) 2015-10-28 2016-11-01 Bayer Healthcare Llc System and method for syringe plunger engagement with an injector
US9744305B2 (en) 2012-09-28 2017-08-29 Bayer Healthcare Llc Quick release plunger
US20170312449A1 (en) * 2014-10-21 2017-11-02 Sulzer Mixpac Ag Dual-chamber syringe
US9855390B2 (en) 2006-03-15 2018-01-02 Bayer Healthcare Llc Plunger covers and plungers for use in syringes
USD847985S1 (en) 2007-03-14 2019-05-07 Bayer Healthcare Llc Syringe plunger cover
US10806852B2 (en) 2014-03-19 2020-10-20 Bayer Healthcare Llc System for syringe engagement to an injector
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
USD942005S1 (en) 2007-03-14 2022-01-25 Bayer Healthcare Llc Orange syringe plunger cover
USD1002840S1 (en) 2007-03-14 2023-10-24 Bayer Healthcare Llc Syringe plunger
US11883636B2 (en) 2018-02-27 2024-01-30 Bayer Healthcare Llc Syringe plunger engagement mechanism
US11969582B2 (en) 2022-06-02 2024-04-30 Bayer Healthcare Llc Syringe plunger with dynamic seal

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US822079A (en) * 1905-05-11 1906-05-29 Louis Roussy Hypodermic syringe.
US1529659A (en) * 1921-12-24 1925-03-17 Ernest H Marcy Hypodermic instrument
US1712070A (en) * 1924-01-30 1929-05-07 Cook Lab Inc Syringe
US1757680A (en) * 1929-02-08 1930-05-06 James B Neil Needle-locking device for syringes
US1961490A (en) * 1931-01-20 1934-06-05 George N Hein Syringe equipment
GB605395A (en) * 1945-12-21 1948-07-22 Universal Metal Products Ltd Improvements relating to collapsible containers adapted for use in effecting hypodermic and like injections
US2478845A (en) * 1947-12-15 1949-08-09 Arthur E Smith Disposable ampoule syringe
US2646798A (en) * 1950-09-21 1953-07-28 Frank E Brown Cartridge syringe
US2648334A (en) * 1949-10-28 1953-08-11 Turnbull Hypodermic injection assembly
US2687727A (en) * 1953-01-19 1954-08-31 Becton Dickinson Co Injection device
US2695613A (en) * 1953-02-16 1954-11-30 Macgregor Instr Company Carpule and needle attaching mount therefor

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US822079A (en) * 1905-05-11 1906-05-29 Louis Roussy Hypodermic syringe.
US1529659A (en) * 1921-12-24 1925-03-17 Ernest H Marcy Hypodermic instrument
US1712070A (en) * 1924-01-30 1929-05-07 Cook Lab Inc Syringe
US1757680A (en) * 1929-02-08 1930-05-06 James B Neil Needle-locking device for syringes
US1961490A (en) * 1931-01-20 1934-06-05 George N Hein Syringe equipment
GB605395A (en) * 1945-12-21 1948-07-22 Universal Metal Products Ltd Improvements relating to collapsible containers adapted for use in effecting hypodermic and like injections
US2478845A (en) * 1947-12-15 1949-08-09 Arthur E Smith Disposable ampoule syringe
US2648334A (en) * 1949-10-28 1953-08-11 Turnbull Hypodermic injection assembly
US2646798A (en) * 1950-09-21 1953-07-28 Frank E Brown Cartridge syringe
US2687727A (en) * 1953-01-19 1954-08-31 Becton Dickinson Co Injection device
US2695613A (en) * 1953-02-16 1954-11-30 Macgregor Instr Company Carpule and needle attaching mount therefor

Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3023751A (en) * 1957-07-02 1962-03-06 Seymour R Lipsky Injection apparatus and ampule
US3074541A (en) * 1959-10-13 1963-01-22 Brunswick Corp Medicinal vial and needle assembly
US3556099A (en) * 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
FR2208683A1 (en) * 1972-12-05 1974-06-28 Mpl Inc Medical syringe with plastics finger grips - fitted on polypropylene sleeve over end of glass tube
US4291695A (en) * 1976-04-05 1981-09-29 Duphar International Research B.V. Disposable injection syringe
US4568336A (en) * 1984-04-26 1986-02-04 Microbiological Applications, Inc. Pre-filled hypodermic syringes
US5137511A (en) * 1987-07-08 1992-08-11 Duoject Medical Systems Inc. Syringe
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US5002538A (en) * 1988-10-25 1991-03-26 Johnson Johnnie M Syringe adapter and method
US5240323A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with extendable agitator bellows
US5240322A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5352036A (en) * 1992-09-23 1994-10-04 Habley Medical Technology Corporation Method for mixing and dispensing a liquid pharmaceutical with a miscible component
US6206858B1 (en) * 1996-12-16 2001-03-27 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Blunt tip cannula with access pin
US6585697B2 (en) 1996-12-16 2003-07-01 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Blunt tip cannula with access pin
US20100256486A1 (en) * 2000-07-10 2010-10-07 Medrad, Inc. Syringes for Medical Injector Systems
US9844622B2 (en) 2000-07-10 2017-12-19 Bayer Healthcare Llc Syringes for medical injector systems
JP2003199827A (en) * 2001-12-28 2003-07-15 Terumo Corp Syringe
US7654986B2 (en) 2002-07-03 2010-02-02 Novo Nordisk A/S Needle mounting system and a method for mounting a needle assembly
CN100502968C (en) * 2002-07-03 2009-06-24 诺沃挪第克公司 A needle mounting system and a method for mounting a needle assembly
US8579869B2 (en) 2002-07-03 2013-11-12 Novo Nordisk A/S Needle mounting system and a method for mounting a needle assembly
US8137325B2 (en) 2002-07-03 2012-03-20 Novo Nordisk A/S Needle mounting system and a method for mounting a needle assembly
US7762994B2 (en) 2002-07-03 2010-07-27 Novo Nordisk A/S Needle mounting system and a method for mounting a needle assembly
US20100211014A1 (en) * 2002-07-03 2010-08-19 Novo Nordisk A/S Needle Mounting System And A Method For Mounting A Needle Assembly
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