US2856930A - Temperature indicator for blood storage container - Google Patents

Temperature indicator for blood storage container Download PDF

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US2856930A
US2856930A US652774A US65277457A US2856930A US 2856930 A US2856930 A US 2856930A US 652774 A US652774 A US 652774A US 65277457 A US65277457 A US 65277457A US 2856930 A US2856930 A US 2856930A
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tube
blood
stopper
bottle
liquid
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US652774A
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Willard M Huyck
Vincent A Romito
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/70—Device provided with specific sensor or indicating means
    • A61J2200/76—Device provided with specific sensor or indicating means for fluid level

Definitions

  • This invention relates to an indicator or telltale device for use in association with a container for the storage for subsequent use of human blood or other physiological liquids.
  • One object of the invention is to provide a telltale or indicator device for use in or in association with a blood storage bottle which by change of appearance above the blood level indicates whether or not the particular batch of blood has reached a temperature which makes it unsafe for use. Another object is to provide a telltale device for a blood storage bottle which will indicate whether or not the contents of the bottle have at any time reached the high temperature at which it becomes unsatisfactory for use, or if it has, after having once reached a dangerous temperature, subsequently been re-chilled to an obstensibly safe refrigeration temperature.
  • Fig. 1 is a side elevational view partly in section showing the essential details of a commonly used form of blood storage bottle including our indicator device installed in the stopper for the bottle;
  • Fig. 2 is a side elevational view showing an indicator pellet for use with the device of Fig. 1;
  • Fig. 3 is a side elevational view of the indicator device of Figs. 1 .and 2 after the pellet has dropped out of sight;
  • Fig. 4 is a side elevational view partly in section of an alternative form of our invention, including a blood storage bottle having an enclosing tube adjustably set in the stopper, which tube is adapted to receive a separate indicator;
  • Fig. 5 is an enlarged side elevational view partly in section of the separate indicator following our invention as shown in Fig. 4;
  • Fig. 6 is a side elevational view partly in section showing the indicator tube with the liquid solidified by cooling, and with an indicator pellet resting on the solidified liquid;
  • Fig. 7 is another view of the indicator device shown in Fig. 5, after the liquid has melted.
  • a con- States Fatent 0 Patented Oct. 21, 1958 2 ventional blood storage bottle consists of a glass bottle 10 having-an inserted stopper 11, preferably of rubber or the like, and also having near the bottom of the bottle a metal band 12 and a bail '13 hingedly attached thereto by which thebottle and contents may be hung in an inverted position, for example during the removal of the contents in a blood transfusion operation.
  • the stopper 11 is provided on the inside of the bottle with a tubular opening 14 which does not go entirely through the stopper, and which permits the puncturing penetration by a hypodermic needle or other instrument, for withdrawal of the blood.
  • the stopper 11 is also provided with'a long glass tube 15 which is mounted in a hole 16 which also does not extend entirely through to the outer face of the stopper but is puncturable by means of a hypodermic needle or the like in order to allow air to enter the container when blood is being withdrawn from the inverted bottle through the opening 14.
  • the bottle stopper 11 is further provided with a glass tube 17 having an open end 18 extending above the outer face of the stopper 11, the lower end- 19 of the glass tube 17 being closed and preferably extending below the blood level line 20 which is marked on the upper side wall of the glass bottle 10.
  • the open end 18 of the tube 17 may be provided with a removable stopper 21.
  • the elevation of the tube 17 is adjustable in and out of the stopper so that if desired the indicator liquid is not visible, but the pellet position of;
  • a quantity of a liquid 23 is placed in the bottom of said tube, which, after chilling (along with the blood contained in the bottle) to a solidifying temperature below 50 F. and preferably to 39 to 43 F.
  • the liquid 23 is selected to melt a few degrees above the selected critical temperature for the blood of about 50 F.
  • the preferred composition of the liquid 23 is 2-undeconone (Eastmans P2209) which has a melting range of- 52 to 55 F.
  • Other solidifiable compositions having melting temperature ranges slightly above 50 F., and which may be used in blood-storage indicators of this invention are iso-amyl stearate having a melting range of 50 to 59 F.; ethyl myristrate having a melting range of 50 to 54 F.; p-bromophenetole having a melting range of 50 to 54 F.; and n-undecyl alcohol having a melting range of 59 to 63 F.
  • These liquids may be contrastingly colored with'suitable dyes to make the liquids more readily visible, as for example by Kreugers oil emerald green conc.
  • a small pellet 24, of glass or the like, as shown in Fig. 2, is a necessary part of our invention, it being contemplated that when the liquid 23 in the tube 17 hasbeen solidified, the stopper 21 is temporarily withdrawn and a pellet 24, of glass or'other solid material which has a I higher specific gravity than the solid 23, is put into the tube 17 and rests upon the solidified liquid 23'.
  • a pellet 24, of glass or'other solid material which has a I higher specific gravity than the solid 23, is put into the tube 17 and rests upon the solidified liquid 23'.
  • the material 23' in the tube 17 melts and the glass pellet 24 sinks to the bottom. This indicates that the blood has been too long above the critical temperature and therefore should not be used. This stage is shown in Fig. 3.
  • the bottle 10 as above described, including the tube 17', is used, but the indicator or telltale is a separate tubularunit 25, which is inserted within the glass tube 17' for use in indicating temperatures in the blood stored in the bottle.
  • This preferred separable telltale device is shown in Figs. 5 to 7.
  • the telltale 25 consists of a glass tube 26 of small enough diameter to be inserted in the enclosing glass tube 17' permanently *assaeso mounted'in the stopper l'l'of the bottle 10.
  • a quantity of solidifying liquid '23 is placed within the glass tube -26', as previously described for the form of the invention shown in Figs. 1 to 3.
  • The-tube 26 is provided with a stopper 27 which isprovided with-whole '28 ⁇ in whit-this slidablly fitted a'rod-likeplunger 29 Whose outer end 30 extendsabove the stopper 27,-a'nd-whose lower'end'malres contact with a; pellet' 24' which is frictionally removably heldin the: loweren'd of thehole 28.
  • The'pellet may'also be -removably held on" theface of thestqpper 'by an'a'dhesivematerial. *The pellet 24 may-be pushed out by pressing theouterend 30 some plunger 29.
  • a sealing coating 31 may be applied'over-the stopper 27 an'd'the adjacent endof the tube -ZG.
  • the separable telltale unit 2 is insertedin theenclosing' tube 17', and is then" refrigerated the 'blood contained in the bottle, and-the liquid 23 issolidified.
  • Sflthe-telltale device may be separately chilled to solidify the material' 23, after which the-pellet 24. may
  • the telltale 25 may then be placed inthe enclosing tube 17'-oithe bottle after the bottle an d bloodhave'been refrigerated to a temperature below the isolidification temperature of the liquid 23'. If the blood in the'bottle subsequentlybecomes warm enough to melt the material 23',-the pellet 24' will drop to the bottom'of the tube 26and no' longer be'visible.
  • the separate unit25 shown in- Fig. 5 may itself be adjustably positioned in the stopper 11, or the unit may merely be attached to or associated with the bottle on the outside thereof.
  • A'telltale device for use with a whole blood storage container comprising an elongated transparent tube having a closed inner'end; a solidifiable liquid haviug amelting point a few degrees above F. corresponding to the critical warmingtemperaturerangefor human blood for use in transfusions, said liquid only partly filling said tube; a stopper in the open end of said tube, said stopper having a movableplunger-movable longiwdinallyla'n a hole therethrough and being held frictionally in :said stopper, :and a pellet having. a higher ,specific,;gravity-ihan said solidifiable liquid, said pellet being initially heldon the.
  • Ihetelltaledevice defined inclaim 1 in which the solidifiable liquid .is pi-bro mophenetole.

Description

Oct. 21, 1958 w. M. HUYCK ETAL TEMPERATURE INDICATOR FOR BLOOD STORAGE CONTAINER Filed April 15, 1957 LIQUID FIG. 5.
FIG. 6. F761 7.
A T TOR/V5) nite TEMPERATURE INDICATOR FOR BLOOD STORAGE CONTAINER Willard M. Huyck, WoodlandHills, and Vincent A. Romito, North Hollywood, Calif.
This invention relates to an indicator or telltale device for use in association with a container for the storage for subsequent use of human blood or other physiological liquids.
In the handling of supplies of human blood after the blood has been taken from donors, it is customary to collect and store the blood in special bottles for refrigeration until the blood is to be used. Whole blood must be stored under refrigeration at temperatures below 50 F. and preferably between 39 and 43 F. It has been established that whole blood must not be used if it has been frozen, and regardless of the temperature must not be used if stored for more than 21 days. Our invention consists generally in providing a visible indicator or telltale device in association with or inside the blood storage bottle which by change of appearance will indicate whether or not the particular bottle of blood has ever, since the initial refrigeration, reached a temperature above 50 R, such as during its transportation from the refrigerator to the'point of use at a hospital operating room or the like.
One object of the invention is to provide a telltale or indicator device for use in or in association with a blood storage bottle which by change of appearance above the blood level indicates whether or not the particular batch of blood has reached a temperature which makes it unsafe for use. Another object is to provide a telltale device for a blood storage bottle which will indicate whether or not the contents of the bottle have at any time reached the high temperature at which it becomes unsatisfactory for use, or if it has, after having once reached a dangerous temperature, subsequently been re-chilled to an obstensibly safe refrigeration temperature.
These and other objects are attained by our invention which will be understood from the following description, reference being made to the accompanying drawings in which:
Fig. 1 is a side elevational view partly in section showing the essential details of a commonly used form of blood storage bottle including our indicator device installed in the stopper for the bottle;
Fig. 2 is a side elevational view showing an indicator pellet for use with the device of Fig. 1;
Fig. 3 is a side elevational view of the indicator device of Figs. 1 .and 2 after the pellet has dropped out of sight;
Fig. 4 is a side elevational view partly in section of an alternative form of our invention, including a blood storage bottle having an enclosing tube adjustably set in the stopper, which tube is adapted to receive a separate indicator;
Fig. 5 is an enlarged side elevational view partly in section of the separate indicator following our invention as shown in Fig. 4;
Fig. 6 is a side elevational view partly in section showing the indicator tube with the liquid solidified by cooling, and with an indicator pellet resting on the solidified liquid; and
Fig. 7 is another view of the indicator device shown in Fig. 5, after the liquid has melted.
Referring to the drawings, particularly Fig. 1, a con- States Fatent 0 Patented Oct. 21, 1958 2 ventional blood storage bottle consists of a glass bottle 10 having-an inserted stopper 11, preferably of rubber or the like, and also having near the bottom of the bottle a metal band 12 and a bail '13 hingedly attached thereto by which thebottle and contents may be hung in an inverted position, for example during the removal of the contents in a blood transfusion operation. The stopper 11 is provided on the inside of the bottle with a tubular opening 14 which does not go entirely through the stopper, and which permits the puncturing penetration by a hypodermic needle or other instrument, for withdrawal of the blood. The stopper 11 is also provided with'a long glass tube 15 which is mounted in a hole 16 which also does not extend entirely through to the outer face of the stopper but is puncturable by means of a hypodermic needle or the like in order to allow air to enter the container when blood is being withdrawn from the inverted bottle through the opening 14. The bottle stopper 11 is further provided with a glass tube 17 having an open end 18 extending above the outer face of the stopper 11, the lower end- 19 of the glass tube 17 being closed and preferably extending below the blood level line 20 which is marked on the upper side wall of the glass bottle 10. The open end 18 of the tube 17 may be provided with a removable stopper 21. The elevation of the tube 17 is adjustable in and out of the stopper so that if desired the indicator liquid is not visible, but the pellet position of;
the indicator is visible. v
In one form of our invention, which includes a blood storage bottle fitted with a tube 17 as described, a quantity of a liquid 23 is placed in the bottom of said tube, which, after chilling (along with the blood contained in the bottle) to a solidifying temperature below 50 F. and preferably to 39 to 43 F. The liquid 23 is selected to melt a few degrees above the selected critical temperature for the blood of about 50 F.
a The preferred composition of the liquid 23 is 2-undeconone (Eastmans P2209) which has a melting range of- 52 to 55 F. Other solidifiable compositions having melting temperature ranges slightly above 50 F., and which may be used in blood-storage indicators of this invention are iso-amyl stearate having a melting range of 50 to 59 F.; ethyl myristrate havinga melting range of 50 to 54 F.; p-bromophenetole having a melting range of 50 to 54 F.; and n-undecyl alcohol having a melting range of 59 to 63 F. These liquids may be contrastingly colored with'suitable dyes to make the liquids more readily visible, as for example by Kreugers oil emerald green conc.
A small pellet 24, of glass or the like, as shown in Fig. 2, is a necessary part of our invention, it being contemplated that when the liquid 23 in the tube 17 hasbeen solidified, the stopper 21 is temporarily withdrawn and a pellet 24, of glass or'other solid material which has a I higher specific gravity than the solid 23, is put into the tube 17 and rests upon the solidified liquid 23'. When the blood in the bottle 10 warms up to a temperature above about 50 F., the material 23' in the tube 17 melts and the glass pellet 24 sinks to the bottom. This indicates that the blood has been too long above the critical temperature and therefore should not be used. This stage is shown in Fig. 3.
In another form of our invention shown in Fig. 4, the bottle 10, as above described, including the tube 17', is used, but the indicator or telltale is a separate tubularunit 25, which is inserted within the glass tube 17' for use in indicating temperatures in the blood stored in the bottle. This preferred separable telltale device is shown in Figs. 5 to 7.
Referring particularly to Fig. 5, the telltale 25 consists of a glass tube 26 of small enough diameter to be inserted in the enclosing glass tube 17' permanently *assaeso mounted'in the stopper l'l'of the bottle 10. Within the glass tube -26'is placed a quantity of solidifying liquid '23, as previously described for the form of the invention shown in Figs. 1 to 3. The-tube 26 is provided with a stopper 27 which isprovided with-whole '28 {in whit-this slidablly fitted a'rod-likeplunger 29 Whose outer end 30 extendsabove the stopper 27,-a'nd-whose lower'end'malres contact with a; pellet' 24' which is frictionally removably heldin the: loweren'd of thehole 28. The'pellet may'also be -removably held on" theface of thestqpper 'by an'a'dhesivematerial. *The pellet 24 may-be pushed out by pressing theouterend 30 some plunger 29. A sealing coating 31 may be applied'over-the stopper 27 an'd'the adjacent endof the tube -ZG.
For useas 'an indicator for the hlood in the bottlef the separable telltale unit 2 is insertedin theenclosing' tube 17', and is then" refrigerated the 'blood contained in the bottle, and-the liquid 23 issolidified. v 'When this conditionhasbeen-attained, the plunger29 is-pressedinto release thepellet "24, which drops and rests upon the solidified surface'of the solidified material 2-3. -When the blood in the bottle has warmed up to'a temperature above 50"F., the sOIidifiedmaterialZS' 'liquifies, and the pellet 24' drops tothe bottom of the tube 26, and is no longer visible above'the top surface of the liquid 23 or above thelevel of the blood in the bottle if the telltale unit" has beenpositioned so'that only the pellet is visible above the bloodline. If the "bottle and contents should be rechilled,the pellet wouldnot'then be located on top of the solidified material '23, and'the indication wouldibe thatthe blood should not be used.
As an alternative manner ,of using the telltaleshown in Fig. "Sflthe-telltale device may be separately chilled to solidify the material' 23, after which the-pellet 24. may
be releasedbythe plunger 29 so that the pellet rests on the solidified material 23'. In this chilled condition, the telltale 25 may then be placed inthe enclosing tube 17'-oithe bottle after the bottle an d bloodhave'been refrigerated to a temperature below the isolidification temperature of the liquid 23'. If the blood in the'bottle subsequentlybecomes warm enough to melt the material 23',-the pellet 24' will drop to the bottom'of the tube 26and no' longer be'visible. The separate unit25 shown in- Fig. 5 may itself be adjustably positioned in the stopper 11, or the unit may merely be attached to or associated with the bottle on the outside thereof.
"The advantages of our invention Will'be apparent from 4 i the above description. Means have been provided for indicating whether'or not theblo ed in the "bottle'has been above the critical high temperature above which it should not be used for transfusions. The telltale device of this invention will also show that'abottle of blood has once (since the initial chilling) been too warm, evemthough subsequently cooled to the usual refrigeration temperature.
We claim:
1. A'telltale device for use with a whole blood storage container comprising an elongated transparent tube having a closed inner'end; a solidifiable liquid haviug amelting point a few degrees above F. corresponding to the critical warmingtemperaturerangefor human blood for use in transfusions, said liquid only partly filling said tube; a stopper in the open end of said tube, said stopper having a movableplunger-movable longiwdinallyla'n a hole therethrough and being held frictionally in :said stopper, :and a pellet having. a higher ,specific,;gravity-ihan said solidifiable liquid, said pellet being initially heldon the. inner faceof said stoppertin a position to be released by movement of said-plunger, said pellet .beingmelease'd to rest on the surface of said-solidifiable liquid after said liquid hasbeen solidified byt-eooling below 50 if.
:2. .Thetelltaledevice defined'in claim Lin whichthe solidifiable liquid is .Z-undeconone. I
3. The :telltale device defined intclaim l in which -the solidifiable liquid .isiso-tamyl stearate.
4. The telltaledevice defined in claiml in whichtthe solidifiable liquid is ethyl myristrate.
..5. Ihetelltaledevice defined inclaim 1 in which the solidifiable liquid .is pi-bro mophenetole.
6..'1The telltale devicedefined'in claim 1-. inwhichthe solidifiable liquidis v-n-undec yl alcohol. l r
'7. .The combination of'thetellta-le device definedin claim 1, .and\a.sealed stopperedblood storage tbottle 'a transparent enclosing tube for said telltale device being, adjustably inserted through the stopper of said bottle, the plunger invthet stopper of said telltale device being; oper-' able 'from theopen end- .of said enclosi-ng tube-from outsidersaidibottle.
: References Cited in the file of-this' patent 'UNITED f STATES PATENTS 2,208,550 Shapiro July 1 6,11940 2,2.61;47-3 Jennings -Nov. 4, 1-'94l 2,780,225 -Barret al. Feb. 5, .1957 2,788,282 =Hammond Apr. 9, 1957

Claims (1)

1. A TELLTALE DEVICE FOR USE WITH A WHOLE BLOOD STORAGE CONTAINER COMPRISING AN ELONGATED TRANSPARENT TUBE HAVING A CLOSED INNER END; A SOLIDIFIABLE LIQUID HAVING A MELTING POINT A FEW DEGREES ABOVE 50*F. CORRESPONDING TO THE CRITICAL WARMING TEMPERATURE RANGE FOR HUMAN BLOOD FOR USE IN TRANSFUSIONS, SAID LIQUID ONLY PARTLY FILLING SAID TUBE; A STOPPER IN THE OPEN END OF SAID TUBE, SAID STOPPER HAVING A MOVABLE PLUNGER MOVABLE LONGITUDINALLY IN A HOLE THERETHROUGH AND BEING HELD FRICTIONALLY IN SAID
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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2983247A (en) * 1960-03-31 1961-05-09 Rand D Corp Temperature tell-tale
US3090236A (en) * 1960-10-15 1963-05-21 Nat Res Dev Temperature indicating devices
FR2463941A1 (en) * 1979-08-17 1981-02-27 Rincon Ind Inc INDICATOR FOR HEATING UNIT FOR DISINFECTING SOFT OR SIMILAR LENSES
US4320087A (en) * 1978-01-23 1982-03-16 Abbott Laboratories Laboratory assay device
FR2665258A1 (en) * 1990-07-25 1992-01-31 Staerk Maria Defrosting (unfreezing) indicator for frozen products and refrigerated products
US5487352A (en) * 1994-09-21 1996-01-30 John R. Williams Temperature indicator for cooked meats
WO1999064831A1 (en) * 1998-06-11 1999-12-16 Volk Enterprises, Inc. Meat timer having downward moving indicator
WO2000010504A1 (en) 1998-08-19 2000-03-02 Cobe Laboratories, Inc. Cell storage maintenance and monitoring system
US6176197B1 (en) 1998-11-02 2001-01-23 Volk Enterprises Inc. Temperature indicator employing color change
US20040243093A1 (en) * 2001-01-10 2004-12-02 Ron Berenson System for growth, analysis, storage, validation and distribution of cells and tissues used for biomedical purposes
US20060051874A1 (en) * 2004-08-19 2006-03-09 Blood Cell Storage Inc. Fluorescent pH detector system and related methods
US20060078036A1 (en) * 2004-10-12 2006-04-13 Wieder Horst K Method and Device for Indicating Temperature
US20070159920A1 (en) * 2006-01-11 2007-07-12 Sartorius Ag Container and method for the mixing of media
US20070251337A1 (en) * 2004-08-19 2007-11-01 Blood Cell Storage, Inc. Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices
US20090325220A1 (en) * 2004-08-19 2009-12-31 Blood Cell Storage, Inc. Methods and apparatus for sterility testing
US9040307B2 (en) 2011-05-27 2015-05-26 Blood Cell Storage, Inc. Fluorescent pH detector system and related methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2208550A (en) * 1938-07-09 1940-07-16 Samuel J Becker Liquid dispensing apparatus
US2261473A (en) * 1938-04-16 1941-11-04 George W Jennings Temperature indicator
US2780225A (en) * 1953-03-03 1957-02-05 Courtland H Barr Sr Blood packaging unit
US2788282A (en) * 1954-06-11 1957-04-09 Jr John Hays Hammond Thermal indicators

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2261473A (en) * 1938-04-16 1941-11-04 George W Jennings Temperature indicator
US2208550A (en) * 1938-07-09 1940-07-16 Samuel J Becker Liquid dispensing apparatus
US2780225A (en) * 1953-03-03 1957-02-05 Courtland H Barr Sr Blood packaging unit
US2788282A (en) * 1954-06-11 1957-04-09 Jr John Hays Hammond Thermal indicators

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2983247A (en) * 1960-03-31 1961-05-09 Rand D Corp Temperature tell-tale
US3090236A (en) * 1960-10-15 1963-05-21 Nat Res Dev Temperature indicating devices
US4320087A (en) * 1978-01-23 1982-03-16 Abbott Laboratories Laboratory assay device
FR2463941A1 (en) * 1979-08-17 1981-02-27 Rincon Ind Inc INDICATOR FOR HEATING UNIT FOR DISINFECTING SOFT OR SIMILAR LENSES
FR2665258A1 (en) * 1990-07-25 1992-01-31 Staerk Maria Defrosting (unfreezing) indicator for frozen products and refrigerated products
US5487352A (en) * 1994-09-21 1996-01-30 John R. Williams Temperature indicator for cooked meats
WO1999064831A1 (en) * 1998-06-11 1999-12-16 Volk Enterprises, Inc. Meat timer having downward moving indicator
WO2000010504A1 (en) 1998-08-19 2000-03-02 Cobe Laboratories, Inc. Cell storage maintenance and monitoring system
US6315767B1 (en) 1998-08-19 2001-11-13 Gambro, Inc. Cell storage maintenance and monitoring system
US6726671B2 (en) 1998-08-19 2004-04-27 Gambro, Inc. Cell storage maintenance and monitoring system
US6176197B1 (en) 1998-11-02 2001-01-23 Volk Enterprises Inc. Temperature indicator employing color change
US20040243093A1 (en) * 2001-01-10 2004-12-02 Ron Berenson System for growth, analysis, storage, validation and distribution of cells and tissues used for biomedical purposes
US20070255249A1 (en) * 2001-01-10 2007-11-01 Ron Berenson System for growth, analysis, storage, validation and distribution of cells and tissues used for biomedical purposes
US7968346B2 (en) 2004-08-19 2011-06-28 Blood Cell Storage, Inc. Fluorescent pH detector system and related methods
US8183052B2 (en) 2004-08-19 2012-05-22 Blood Cell Storage, Inc. Methods and apparatus for sterility testing
US10156578B2 (en) 2004-08-19 2018-12-18 Blood Cell Storage, Inc. Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices
US20070251337A1 (en) * 2004-08-19 2007-11-01 Blood Cell Storage, Inc. Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices
US7608460B2 (en) 2004-08-19 2009-10-27 Blood Cell Storage, Inc. Fluorescent pH detector system and related methods
US20090325220A1 (en) * 2004-08-19 2009-12-31 Blood Cell Storage, Inc. Methods and apparatus for sterility testing
US20060051874A1 (en) * 2004-08-19 2006-03-09 Blood Cell Storage Inc. Fluorescent pH detector system and related methods
US9217170B2 (en) 2004-08-19 2015-12-22 Blood Cell Storage, Inc. Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices
US8497134B2 (en) 2004-08-19 2013-07-30 Blood Cell Storage, Inc. Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices
US8148167B2 (en) 2004-08-19 2012-04-03 Blood Cell Storage, Inc. Fluorescent pH detector system and related methods
US20060078036A1 (en) * 2004-10-12 2006-04-13 Wieder Horst K Method and Device for Indicating Temperature
US7097353B2 (en) 2004-10-12 2006-08-29 Wieder Horst K Method and device for indicating temperature
US20090147617A1 (en) * 2006-01-11 2009-06-11 Sartorius Stedim Biotech Gmbh Container and method for the mixing of media
US8123397B2 (en) * 2006-01-11 2012-02-28 Sartorius Stedim Biotech Gmbh Disposable container having sensor mounts sealed to the container and sensors in the sensor mounts for measuring at least one parameter of media in the container
US8123395B2 (en) * 2006-01-11 2012-02-28 Sartorius Stedim Biotech Gmbh Method for mixing media in a container
US20070159920A1 (en) * 2006-01-11 2007-07-12 Sartorius Ag Container and method for the mixing of media
US9040307B2 (en) 2011-05-27 2015-05-26 Blood Cell Storage, Inc. Fluorescent pH detector system and related methods

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