US3027333A - Electrically conductive emulsions - Google Patents

Electrically conductive emulsions Download PDF

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Publication number
US3027333A
US3027333A US705820A US70582057A US3027333A US 3027333 A US3027333 A US 3027333A US 705820 A US705820 A US 705820A US 70582057 A US70582057 A US 70582057A US 3027333 A US3027333 A US 3027333A
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United States
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electrically conductive
skin
salt
sodium
sodium chloride
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US705820A
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Nathan H Friedman
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Burton Parsons Chemicals Inc
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Burton Parsons Chemicals Inc
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Priority to US705820A priority Critical patent/US3027333A/en
Priority to FR782674A priority patent/FR1227265A/en
Priority to GB42084/58A priority patent/GB911185A/en
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Publication of US3027333A publication Critical patent/US3027333A/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25Bioelectric electrodes therefor
    • A61B5/251Means for maintaining electrode contact with the body
    • A61B5/257Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes
    • A61B5/259Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes using conductive adhesive means, e.g. gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/16Amines or polyamines

Definitions

  • the present invention relates to electrically conductive systems, and particularly to a new and improved system for use with electrodes in making cardiograms.
  • Diiferent parts of the surface of the body have different resistances to the passage of electric current. Some skin may be dry and thick, whereas other skin may be moist and thin. Still other skin may be oily, and the degree of hair on skin varies widely. All of these skin characteristics act to vary the passage of electric current from the body of a patient to electrocardiographic equipment thereby providing erratic tracings.
  • the principal object of this invention is to provide a system that will act to enhance the passage of electric current between the body of a patient and electrocardiographic equipment.
  • Another object of this invention is to provide such a system that will be readily applied and readily removed without any resulting condition requiring cleansing.
  • Another object of the invention is to provide such a system that will not only cleanse the skin, but will provide high conductivity between the skin and electrocardiographic electrodes.
  • Another object of the invention is to provide such a system in which, when applied to the body of a patient, contact dermatitis is lessened while increased conductivity is provided.
  • Another object of this invention is to provide such a system in which the growth of bacteria, molds or yeast is inhibited.
  • One aspect of this invention may be to provide an aqueous system that may include a base of emulsified material of an anionic, cationic, non-ionic or amphoteric type.
  • Another aspect of the invention may be to include with said base, any salt suitable to act as a conductor for the passage of electric current from an electrode to the body of a patient.
  • Still another aspect of the invention may be to employ a bufier solution with the system in order to provide the degree of acidity corresponding substantially to the acid mantle of the body skin.
  • inhibitors for preventing the growth of bacteria, molds or yeast may be included, although such inhibitors may be dispensed with if the system is packaged in a pressure dispensing container of the type commonly known as aerosol packages.
  • the base of the system forming this invention may comprise an aqueous system of an emuslified material which may be of an anionic, cationic, non-ionic or amphoteric type.
  • emuslified material which may be of an anionic, cationic, non-ionic or amphoteric type.
  • non-ionic materials may be selected from the group including polyglycol fatty acids, Spans and Tweens and the like.
  • Span is the registered trademark of the Atlas Powder Company for a series of non-ionic surface active agents which are long chain fatty acid partial esters of hexitol anhydrides, including sorbitans, sorbides, mannitans, and mannides.
  • Tween is the registered trademark of the Atlas Powder Company for a series of non-ionic surface active agents which are polyoxy alkylene derivatives of hexitol anhydride partial long chain fatty acid esters.
  • aqueous system of an emulsified material and a highly ionizable salt may be employed alone, should it be desired to produce a pH in the system that will correspond substantially to the acid mantle of the bodily skin, any one of many buifer solutions may be utilized, among which may be included a sodium citrate, a citric acid, or a phosphate buffer solution.
  • the amount of bufier solution employed should be such as to produce a pH of between substantially 4.2 to 6.
  • Non-ionic Percentage Sodium nitrite 0.1
  • Non-ionic blend of ethylene oxide derivatives of lanolin-higher fatty alcohols 6.0 Cetyl alcohol 2.0 Sodium chloride 5.0 Glycerin 5.0 pH 5 Bufier solution 81.9
  • the above systems were packaged by introducing 142 grams of each into six-ounce containers which were then pressurized to about p.s.i. with nitrogen.
  • An electrically conductive stable emulsion for use with body contact electrodes of electrocardiograph equipment consisting essentially of water as a dispersion me dium, from about 3.5 to 11% of methylene bis stearamide in combination With about 1.0 to 1.7% of stearylpoly oxyethylamine as a liquid dispersion phase, from about 1 to 10% of a highly ionizable salt for controlling the electrical conductivity of the emulsion, said salt being a member selected from the group consisting of sodium chloride, potassium chloride and sodium sulfate, and a bulfer solution in sufiicient amount to provide'an overall composition-pH of about that of the acid mantle of the skin.
  • An electrically conductive stable emulsion for use with body contact electrodes of electrocardiograph equipment consisting essentially of water as a dispersion medium, from about 3.5 to 11% of glyceryl monostearate in combination with about 1.0 to 1.7% of sodium lauryl sulfate as a liquid dispersion phase, from about 1 to 10% of a highly ionizable salt for controlling the electrical conductivity of the emulsion, said salt being a member selected from the group'consisting of sodium chloride, potassium chloride and'sodium sulfate, and a buffer solution in sufiicient amount to provide an overall composition 3 pH of about that of the acid mantle of. the skin.

Description

United States Patent 3,027,333 ELECTRICALLY CONDUCTIVE EMULSIONS Nathan H. Friedman, Stratford, Conn., assignor to Burton Parsons Chemicals, Inc., Washington, D.C., a corporation of Delaware No Drawing. Filed Dec. 30, 1957, Ser. No. 705,820 7 Claims. (Cl. 252-521) The present invention relates to electrically conductive systems, and particularly to a new and improved system for use with electrodes in making cardiograms.
Diiferent parts of the surface of the body have different resistances to the passage of electric current. Some skin may be dry and thick, whereas other skin may be moist and thin. Still other skin may be oily, and the degree of hair on skin varies widely. All of these skin characteristics act to vary the passage of electric current from the body of a patient to electrocardiographic equipment thereby providing erratic tracings.
The principal object of this invention is to provide a system that will act to enhance the passage of electric current between the body of a patient and electrocardiographic equipment. 1
Another object of this invention is to provide such a system that will be readily applied and readily removed without any resulting condition requiring cleansing.
Another object of the invention is to provide such a system that will not only cleanse the skin, but will provide high conductivity between the skin and electrocardiographic electrodes.
Another object of the invention is to provide such a system in which, when applied to the body of a patient, contact dermatitis is lessened while increased conductivity is provided.
Another object of this invention is to provide such a system in which the growth of bacteria, molds or yeast is inhibited.
One aspect of this invention may be to provide an aqueous system that may include a base of emulsified material of an anionic, cationic, non-ionic or amphoteric type.
Another aspect of the invention may be to include with said base, any salt suitable to act as a conductor for the passage of electric current from an electrode to the body of a patient.
Still another aspect of the invention may be to employ a bufier solution with the system in order to provide the degree of acidity corresponding substantially to the acid mantle of the body skin.
Finally, inhibitors for preventing the growth of bacteria, molds or yeast may be included, although such inhibitors may be dispensed with if the system is packaged in a pressure dispensing container of the type commonly known as aerosol packages.
The above as well as other objects and novel features of the invention will become apparent from the following specification.
The base of the system forming this invention may comprise an aqueous system of an emuslified material which may be of an anionic, cationic, non-ionic or amphoteric type. Such non-ionic materials may be selected from the group including polyglycol fatty acids, Spans and Tweens and the like.
Span is the registered trademark of the Atlas Powder Company for a series of non-ionic surface active agents which are long chain fatty acid partial esters of hexitol anhydrides, including sorbitans, sorbides, mannitans, and mannides.
Tween is the registered trademark of the Atlas Powder Company for a series of non-ionic surface active agents which are polyoxy alkylene derivatives of hexitol anhydride partial long chain fatty acid esters.
3,027,333 Patented Mar. 27, 1962 "ice Percent Sodium chloride l-lO Potassium chloride l-l0 Sodium sulf e 1-10 or any highly ionizable salt in concentrations to achieve suitable conductivities.
Although the aqueous system of an emulsified material and a highly ionizable salt may be employed alone, should it be desired to produce a pH in the system that will correspond substantially to the acid mantle of the bodily skin, any one of many buifer solutions may be utilized, among which may be included a sodium citrate, a citric acid, or a phosphate buffer solution. The amount of bufier solution employed should be such as to produce a pH of between substantially 4.2 to 6.
Should the system be packaged in containers that are opened to the atmosphere during use, means may be required to prevent the growth of bacteria, molds or yeast. Such materials as esters of para-hydroxy benzoic acid or other suitable inhibitors may be employed. Should, however, the aqueous system be packaged in a pressure dispensing container of the type known as aerosol packages, the above inhibitors may not be required.
Examples of an aqueous system embodying the principles of this invention'are:
Non-ionic: Percentage Sodium nitrite 0.1 Non-ionic blend of ethylene oxide derivatives of lanolin-higher fatty alcohols 6.0 Cetyl alcohol 2.0 Sodium chloride 5.0 Glycerin 5.0 pH 5 Bufier solution 81.9
0f. T. C. MacIlvaine, Journal of Biol. Chem. 49, 183
(1921) C. J. Schollenberger, The Chemist-Analysist, 19, No.
Cationic:
Methylene bis-stearmide 10.0 Stearyl polyoxyethylamine 1.7 Glacial acetic acid 0.3 Sodium nitrit 0.1 Sodium chloride 5 .0 Glycerin 5.0 pH 5 Butler solution 77.9 Anionic:
Sodium lauryl sulfate 1.0 Glyceryl monostearate (free from soap) 11.0 Cetyl alcohol 1.0 Sodium nitrite 0.1 Sodium chloride 5.0 Glycerin 5.0 Water, distilled or de-ionized 76.9
Dispersion:
Magnesium aluminum silicate 3.5 Sodium chloride 5.0 pH 5 Buffer solution 91.5
Cf. '1. C. Macllvaine, Journal of Biol. Chem. 49, 183 (1921) C. J. Schollenberger, The Chemist-Analysist, 19, No. 3, 8 (1930).
The above systems were packaged by introducing 142 grams of each into six-ounce containers which were then pressurized to about p.s.i. with nitrogen.
Although the various features of the new and improved electrically conductive system have been described in detail to fully disclose several embodiments of the invention, it will be evident that numerous changes may be made in such details and certain features may be used without others without departing from the principles of the invention.
What is claimed is:
1. An electrically conductive stable emulsion for use with body contact electrodes of electrocardiograph equipment consisting essentially of water as a dispersion me dium, from about 3.5 to 11% of methylene bis stearamide in combination With about 1.0 to 1.7% of stearylpoly oxyethylamine as a liquid dispersion phase, from about 1 to 10% of a highly ionizable salt for controlling the electrical conductivity of the emulsion, said salt being a member selected from the group consisting of sodium chloride, potassium chloride and sodium sulfate, and a bulfer solution in sufiicient amount to provide'an overall composition-pH of about that of the acid mantle of the skin.
2. The electrically conductive composition of claim 1 wherein the highly ionizable salt is sodium chloride.
3. The electrically conductive composition of claim 1 in which the overall pH is 4.2 to 6.
4. An electrically conductive stable emulsion for use with body contact electrodes of electrocardiograph equipment consisting essentially of water as a dispersion medium, from about 3.5 to 11% of glyceryl monostearate in combination with about 1.0 to 1.7% of sodium lauryl sulfate as a liquid dispersion phase, from about 1 to 10% of a highly ionizable salt for controlling the electrical conductivity of the emulsion, said salt being a member selected from the group'consisting of sodium chloride, potassium chloride and'sodium sulfate, and a buffer solution in sufiicient amount to provide an overall composition 3 pH of about that of the acid mantle of. the skin.
5. The electrically conductive composition of claim 4 wherein the highly ionizable salt is sodium chloride.
6. The electrically conductive composition of claim 4 in which the overall pH is 4.2 to 6.
7. In a method of making electrocardiograms utilizing skin contact electrodes, the improvement comprising ap plying between the electrodes and the skin an electrically conductive stable emulsion consisting essentially of water as a disperion medium, from about 3.5 to 11% of an emulsifiable water immiscible material in combination with about 1.0 to 1.7% of an emulsifying agent as the liquid dispersion phase, from about 1 to 10% of a highly ionizable salt for controlling the electrical conductivity of the emulsion, said salt being a member selected from the group-consisting of sodium chloride, potassium chloride, and sodium sulfate, and a buffer solution in sufficient amount to provide an overall composition pH of about that of the acid'mantle of the body skin.
References Cited in the file of this patent UNITED STATES PATENTS 2,534,204 Mowry Dec. 12, 1950 2,555,037 Jensen May 29, 1951 OTHER REFERENCES Bennett: The Chemical Formulary, vol. IX, page 117,
vol. X, page 61, pub. by Chemical Pub. Co., Brooklyn, NY

Claims (1)

1. AN ELECTRICALLY CONDUCTIVE STABLE EMULSION FOR USE WITH BODY CONTACT ELECTRODES OF ELECTROCARDIOGRAPH EQUIPMENT CONSISTING ESSENTIALLY OF WATER AS A DISPERSION MEDIUM, FROM ABOUT 3.5 TO 11% OF METHYLENE BIS STEARAMIDE IN COMBINATION WITH ABOUT 1.0 TO 1.7% OF STEARYLPOLY OXYETHYLAMINE AS A LIQUID DISPERSION PHASE, FROM ABOUT 1 TO 10% OF A HIGHLY IONIZABLE SALT FOR CONTROLLING THE ELECTRICAL CONDUCTIVITY OF THE EMULSION, SAID SALT BEING A MEMBER SELECTED FROM THE GROUP CONSISTING OF SODIUM CHLORIDE, POTASSIUM CHLORIDE AND SODIUM SULFATE, AND A BUFFER SOLUTION IN SUFFICIENT AMOUNT TO PROVIDE AN OVERALL COMPOSITION PH TO ABOUT THAT OF THE ACID MANTLE OF THE SKIN.
US705820A 1957-12-30 1957-12-30 Electrically conductive emulsions Expired - Lifetime US3027333A (en)

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US705820A US3027333A (en) 1957-12-30 1957-12-30 Electrically conductive emulsions
FR782674A FR1227265A (en) 1957-12-30 1958-12-26 Electrical conductive assemblies, in aqueous system, in particular for taking cardiograms
GB42084/58A GB911185A (en) 1957-12-30 1958-12-30 Electrically conductive compositions

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Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265638A (en) * 1964-03-24 1966-08-09 Franklin Institute Electrolyte composition
DE2302618A1 (en) * 1972-01-21 1973-07-26 Ndm Corp ELECTRODE FOR TAKING UP BIOELECTRIC POTENTIAL
US3862633A (en) * 1974-05-06 1975-01-28 Kenneth C Allison Electrode
US3998215A (en) * 1968-12-18 1976-12-21 Minnesota Mining And Manufacturing Company Bio-medical electrode conductive gel pads
US4016869A (en) * 1974-11-18 1977-04-12 Siemens Aktiengesellschaft Signal collector system
US4066078A (en) * 1976-02-05 1978-01-03 Johnson & Johnson Disposable electrode
US4125110A (en) * 1975-11-25 1978-11-14 Hymes Alan C Monitoring and stimulation electrode
US4215696A (en) * 1978-03-20 1980-08-05 Graphic Controls Corporation Biomedical electrode with pressurized skin contact
US4274420A (en) * 1975-11-25 1981-06-23 Lectec Corporation Monitoring and stimulation electrode
US4318746A (en) * 1980-01-08 1982-03-09 Ipco Corporation Highly stable gel, its use and manufacture
US4362165A (en) * 1980-01-08 1982-12-07 Ipco Corporation Stable gel electrode
US4377170A (en) * 1980-12-01 1983-03-22 Minnesota Mining And Manufacturing Company Non-polarizable bioelectrode
USRE31454E (en) * 1975-11-25 1983-12-06 Lectec Corporation Monitoring and stimulation electrode
US4465074A (en) * 1982-04-20 1984-08-14 Gilbert Buchalter Method of applying an electrode to the skin of a patient
US4498474A (en) * 1979-05-29 1985-02-12 Edward Chalmers Epilation method
US4838273A (en) * 1979-04-30 1989-06-13 Baxter International Inc. Medical electrode
US5088978A (en) * 1990-01-26 1992-02-18 Gensia Pharmaceuticals, Inc. Apparatus and method for iontophoretic transfer
WO1996011631A1 (en) * 1994-10-17 1996-04-25 Biofield Corp. Dc biopotential sensing electrode and electroconductive medium for use therein
US5660177A (en) * 1991-11-04 1997-08-26 Biofield Corp. D.C. biopotential sensing electrode assemblies for apparatus for disease, injury and bodily condition screening or sensing
US5823957A (en) * 1994-10-17 1998-10-20 Biofield Corp D.C. biopotential sensing electrode and electroconductive medium for use therein
US20040023849A1 (en) * 2002-06-28 2004-02-05 Robinson Dale L. Skin conduction and transport systems

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3848600A (en) * 1972-02-03 1974-11-19 Ndm Corp Indifferent electrode in electrosurgical procedures and method of use
US4317450A (en) * 1979-05-29 1982-03-02 Edward Chalmers Method of epilation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2534204A (en) * 1947-12-30 1950-12-12 Monsanto Chemicals Method of preparing amides
US2555037A (en) * 1949-06-21 1951-05-29 Jensen Lee Flexible electrode

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2534204A (en) * 1947-12-30 1950-12-12 Monsanto Chemicals Method of preparing amides
US2555037A (en) * 1949-06-21 1951-05-29 Jensen Lee Flexible electrode

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265638A (en) * 1964-03-24 1966-08-09 Franklin Institute Electrolyte composition
US3998215A (en) * 1968-12-18 1976-12-21 Minnesota Mining And Manufacturing Company Bio-medical electrode conductive gel pads
DE2302618A1 (en) * 1972-01-21 1973-07-26 Ndm Corp ELECTRODE FOR TAKING UP BIOELECTRIC POTENTIAL
US3946730A (en) * 1972-01-21 1976-03-30 Ndm Corporation Biomedical electrode assembly
US3862633A (en) * 1974-05-06 1975-01-28 Kenneth C Allison Electrode
US4016869A (en) * 1974-11-18 1977-04-12 Siemens Aktiengesellschaft Signal collector system
USRE31454E (en) * 1975-11-25 1983-12-06 Lectec Corporation Monitoring and stimulation electrode
US4125110A (en) * 1975-11-25 1978-11-14 Hymes Alan C Monitoring and stimulation electrode
US4274420A (en) * 1975-11-25 1981-06-23 Lectec Corporation Monitoring and stimulation electrode
US4066078A (en) * 1976-02-05 1978-01-03 Johnson & Johnson Disposable electrode
US4215696A (en) * 1978-03-20 1980-08-05 Graphic Controls Corporation Biomedical electrode with pressurized skin contact
US4838273A (en) * 1979-04-30 1989-06-13 Baxter International Inc. Medical electrode
US4498474A (en) * 1979-05-29 1985-02-12 Edward Chalmers Epilation method
US4362165A (en) * 1980-01-08 1982-12-07 Ipco Corporation Stable gel electrode
US4318746A (en) * 1980-01-08 1982-03-09 Ipco Corporation Highly stable gel, its use and manufacture
US4377170A (en) * 1980-12-01 1983-03-22 Minnesota Mining And Manufacturing Company Non-polarizable bioelectrode
US4465074A (en) * 1982-04-20 1984-08-14 Gilbert Buchalter Method of applying an electrode to the skin of a patient
US5088978A (en) * 1990-01-26 1992-02-18 Gensia Pharmaceuticals, Inc. Apparatus and method for iontophoretic transfer
US5660177A (en) * 1991-11-04 1997-08-26 Biofield Corp. D.C. biopotential sensing electrode assemblies for apparatus for disease, injury and bodily condition screening or sensing
WO1996011631A1 (en) * 1994-10-17 1996-04-25 Biofield Corp. Dc biopotential sensing electrode and electroconductive medium for use therein
US5823957A (en) * 1994-10-17 1998-10-20 Biofield Corp D.C. biopotential sensing electrode and electroconductive medium for use therein
US20040023849A1 (en) * 2002-06-28 2004-02-05 Robinson Dale L. Skin conduction and transport systems
US7099713B2 (en) * 2002-06-28 2006-08-29 Battelle Memorial Institute Skin conduction and transport systems

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FR1227265A (en) 1960-08-19
GB911185A (en) 1962-11-21

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