US3040748A - Vascular positioning method and device - Google Patents

Vascular positioning method and device Download PDF

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US3040748A
US3040748A US839638A US83963859A US3040748A US 3040748 A US3040748 A US 3040748A US 839638 A US839638 A US 839638A US 83963859 A US83963859 A US 83963859A US 3040748 A US3040748 A US 3040748A
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cylinder
piston
bushing
nozzle
vessel
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US839638A
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George J Klein
Christoph L Fischer
Ernest S Turner
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National Research Council of Canada
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National Research Council of Canada
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis

Definitions

  • -It is an object of this invention to provide a method and device of simple structure which may be employed to eiect with convenience and facility the threading and,
  • ARIGURE 1 is a sectional side elevation of a device in accordance with the invention, showing one position thereof with associated parts of a suturing apparatus.
  • FIGURE 2 is a sectional side elevation of the device, showing another position thereof, and
  • FIGURE 3 is a sectional side elevation of parts of the suturing apparatus with associated means for threading the vessel through the bushing.
  • 1 is a bushing, 2 a bushing holder, and 3 a hemostatic clamp, all being parts of a suturing apparatus.
  • a flexible tube 5 of suitable plastic composition has one end placed loosely over the end of the bushing and its other end connected to a moderately high volume suction air pump, such as that of a domestic vacuum cleaner.
  • the other end of the bushing is applied to the free end portion of the blood vessel 4 and the flow of airthrough the bushing draws the vessel through the bushing without causing injury to the blood vessel.
  • the pressure difference through the suction pump at zero air flow should not be greater than normal blood pressure or about 2 pounds per square inch.
  • the hemostatic clamp 3 engages the holder Zand may be locked thereto.
  • a vascular everting dev-ice in accordance with the invention is generally indicated at 6, and comprises a cylindrical body or cylinder 7 having a cylindrical bore 8.
  • the cylinder has a rearward end closure plate 9, the forward end thereof lbeing open.
  • the forward end edge 9a of the cylinder is of reduced thickness, as provided by the outer bevelled surface 10 and is of rounded contour.
  • a piston 11 is reciprocally mounted in the cylinder and has a forwardly extending nose 12 the end of which is tapered substantially to an apex, as shown, and through which extends a restricted orifice 13, thus providing a nozzle 14.
  • 'Ilhe piston has a rearwardly extendling rod 15 which extends through closure plate 9.
  • the piston has a longitudinal interior passage 17 which extends through the nose 12 and rod 15 and with which the nozzle himself 13 communicates.
  • the rearward end of passage 17 ⁇ is closed by a screw 18, the head 18a of which seats upon the closure plate 9 in one position of the piston and acts as ⁇ a stop to define such position. In such position, the ypiston is located closely adjacent the forward end of the cylinder with the nose 12 projecting forwardly ⁇ of the cylinder. Since the rod 15 is of less diameter than the piston, an annular space 19 is formed between the rod and the interior wall of the cylinder. Space 19 communicates with the passage 17 in the piston by means of holes 20 extending through the piston.
  • the cylinder 7 is provi-ded with a stem 21 mounted on the rearward end thereof and having a longitudinal passage 22 therein communicating with space 19 through an aligned hole 23.
  • a conduit 24 is removably connecte-d to stem 21 for admitting fluid under pressure to the passage 22.
  • the conduit 24 may be part of a syringe (not shown) or other source ⁇ of iluid under pressure.
  • the iiow of uid supplied through conduit 24 is controlled by operation ⁇ of the syringe, when such is employed, or by a valve '24a when the conduit is connected to other source of uid under pressure.
  • a flexible ring or collar 25 of soft rubber or like material is arranged to be applied to the nose 12.
  • the ring 25 has a tubular sleeve or neck 26 adapted to be seated on the nose 12 which preferably is provided with a recess 27, a radial annular tlange 2S projecting outwardly from the neck, and a peripheral rib 29 adapted to seat on 'the forward outer surface of the cylindrical body 7.
  • the operator applies his thumb to the stop lilato locate the piston in forward position, and a v collar 25 is applied to the nos-e 12, as shown in FIGURE 1.
  • the nozzle 14 is then applied to the mouth of the blood vessel and fluid under pressure is -admitted to passage 22.
  • the uid may be any iluid of sterile nature, such as a low pressure gas or saline solution as commonly used in surgical operations.
  • the uid ows through passage 22, hole 23, space 19, hole or holes 20, passage 17, and emerges as a tine jet through nozzle orifice 13. Since the ⁇ diameter of the piston rod 15 is less than the interior diameter of the cylinder, the piston will be held in its forward position under Ili-ght load because of the iluid pressure in space 19.
  • the issuing tine jet opens the mouth of the vessel. Since the hemostatic clamp ⁇ produces a restriction in the blood vessel, further application of fluid under pressure and movement of the nose 12 into the vessel results in a return flow of fluid between the Vessel wall and the piston nose which expands the vessel and permits the end of the vessel to slide over the sleeve 26 of the collar 25. At this point, admission of fluid under pressure is arrested, thus removing pressure on the pist-on and permitting it to move freely.
  • the everting operation is completed by moving the cylinder '7 towards the bushing, which causes the collar v2,5 to be turned inside out by engagement of the end edge 9a with the ange 29S of the collar. This action also everts the overlying portion of the blood vessel, as shown in FIGURE 2.
  • the everting operation may be performed as described in a very short space of time and in a dependable and positive manner. Excessive pressure on the wall of the vessel between the end of the bushing and the nose of the piston is completely avoided.
  • the everting device described is simple to manufacture, and is subject to convenient and effective washing and sterilization.
  • the everter will he chosen to correspond with the size of the lbushing employed in the suturing apparatus.
  • a method of positioning the end'of a blood vessel on a suturing apparatus bushing which comprises'applying suction induced air dow to one end of said bushing while applying the other end of said bushing to the end of said blood vessel to draw said hlood Vessel end into said bushing, applying a jet of fluid to the mouth of said lblood vessel While in said bushing to expand said mouth, and while maintaining said mouth in expanded condition turning said end of sai-d blood vessel inside out upon the outside surface of said bushing.
  • a vascular everter comprising a cylinder of uniform inter-nal diameter having a closed end and a free end edge dening an open end, a piston reciprocally mounted in said cylinder and having a nose of smaller diameter than the internal diameter of said cylinder directed towards said open end and having a large ⁇ diameter portion engaging said cylinder, said large diameter portion having an end face contiguous with said nose and directed towards said open end, a nozzle axially arranged in said nose, and
  • a piston rod extending through said closed end, said cylinder having an annular space surrounding said piston rod, said piston rod having a passage therein communicating with said annular space and said nozzle, said nose projecting forwardly of saidcylinder in one position of said piston, means for admitting a controlled supply of ⁇ iluid under pressure to said annular space to produce a uid jet through said nozzle, and a flexible collar removably seated on said nose, said collar having a radially extending annular portion of a diameter greater than the internal diameter of said cylinder for engagement by said free end edge of said cylinder to turn said collar inside out on reciprocation of said cylinder relatively to said piston.
  • a vascular everter comprising a cylinder of uniform internal diameter having a closed end and a free end edge dening an open end, a piston reciproca-Hy mounted in said cylinder and having thereonra rearwardly extending piston rod, said piston having a forwardly projecting nozzle of smaller diameterrthan the internal diameter of said cylinder, and having a large diameter portion engaging said cylinder, said large diameter portion having an end face contiguous with said nozzle and directed towards said open end, a stop on the end of said piston rod engageable with said cylinder closed end to define a forward position of said piston, said nozzle projecting forwardly through said open end of said cylinder ⁇ when said piston is in said forward position, said cylinder having an annular space surrounding said piston rod, said piston having a passage therein communicating with said annular space and with said nozzle, means for admitting a controlled supply of fluid under pressure to said annular space and a flexible collar removably seated on said nozzle and having a radially extending annular portion of a diameter greater than
  • a vascular everter comprising ay cylinder of uniform internal diameter having a closed end and a free end edge defining an open end, a piston reciprocally mounted in said cylinder and having thereon a rearwardly extending piston rod, said piston having a forwardly projecting nozzle of smaller diameter than the internal diameter of said cylinder, and having a large diameter portion engaging said cylinder, said large diameter portion having an end face contiguous with said nozzle and directed towards said open end, a stop on the end of said piston rod engagea'ble with said cylinder closed end to define a forward position of said piston, said nozzle projecting forwardly through said open end of said cylinder when said piston is in said forward position, said cylinder having an annular space surrounding said piston rod, said piston having a passage therein communicating with said annular space and with said nozzle, and means for admitting a controlled supply of fluid under pressure to said annular space.

Description

June 26, 1962 G. J. KLEiN ETAL vAscuLAR PosITIoNING METHOD AND DEVICE:
Filed Sept. 14, 1959 United dtates 3,040,743 VASCULAR PUSITIONING METHOD AND DEVICE George .1. Klein, Ottawa, Ontario, Christoph L. Fischer,
Eastview, Ontario, and Ernest S. Turner, Ottawa, Ontario, Canada, assignors to National Research Council, Ottawa, Ontario, Canada, a corporation of Canada Filed Sept. 14, 1959, Ser. No. 839,638 4 Claims. (Cl. 12S- 334) This invention relates to a vascular positioning method and device.
In the use of vascular suturing apparatus, such as described in copending application, Serial No. 717,656, filed February 26, 1958, now Patent No. 2,940,451, it is necessary to thread each severed end portion `of a blood vessel through a bushing and then to evert such end portion over the end of the bushing. The everted ends, held in appropriate position by the bushings and associated holders, are then joined together by means of clips.
It Will be apparent that the steps of threading the vessel through a bushing and then turning the vessel inside out over the end of the bushing are of exacting nature and very diilcult to perform, particularly in respect of small vessels such as those of 4 mm. or less in diameter.
-It is an object of this invention to provide a method and device of simple structure which may be employed to eiect with convenience and facility the threading and,
everting steps mentioned above in respect of very small as well as large sizes of blood vessels.
The invention will be described with reference to the accompanying drawings, in which ARIGURE 1 is a sectional side elevation of a device in accordance with the invention, showing one position thereof with associated parts of a suturing apparatus.
FIGURE 2 is a sectional side elevation of the device, showing another position thereof, and
FIGURE 3 is a sectional side elevation of parts of the suturing apparatus with associated means for threading the vessel through the bushing.
In the drawing, 1 is a bushing, 2 a bushing holder, and 3 a hemostatic clamp, all being parts of a suturing apparatus. The end portion of a severed blood vessel, which it is desired to position on the bushing, is indicated at 4.
The step of threading the blood vessel portion 4 through the bushing 1 will rst be described with particular reference to FIGURE 3. A flexible tube 5 of suitable plastic composition has one end placed loosely over the end of the bushing and its other end connected to a moderately high volume suction air pump, such as that of a domestic vacuum cleaner. The other end of the bushing is applied to the free end portion of the blood vessel 4 and the flow of airthrough the bushing draws the vessel through the bushing without causing injury to the blood vessel. In this connection, the pressure difference through the suction pump at zero air flow should not be greater than normal blood pressure or about 2 pounds per square inch.
As shown, on completion of the threading operation, the hemostatic clamp 3 engages the holder Zand may be locked thereto. Y
A vascular everting dev-ice in accordance with the invention is generally indicated at 6, and comprises a cylindrical body or cylinder 7 having a cylindrical bore 8. The cylinder has a rearward end closure plate 9, the forward end thereof lbeing open. Preferably, the forward end edge 9a of the cylinder is of reduced thickness, as provided by the outer bevelled surface 10 and is of rounded contour. A piston 11 is reciprocally mounted in the cylinder and has a forwardly extending nose 12 the end of which is tapered substantially to an apex, as shown, and through which extends a restricted orifice 13, thus providing a nozzle 14. 'Ilhe piston has a rearwardly extendling rod 15 which extends through closure plate 9. The piston has a longitudinal interior passage 17 which extends through the nose 12 and rod 15 and with which the nozzle orice 13 communicates. YThe rearward end of passage 17\is closed by a screw 18, the head 18a of which seats upon the closure plate 9 in one position of the piston and acts as `a stop to deine such position. In such position, the ypiston is located closely adjacent the forward end of the cylinder with the nose 12 projecting forwardly `of the cylinder. Since the rod 15 is of less diameter than the piston, an annular space 19 is formed between the rod and the interior wall of the cylinder. Space 19 communicates with the passage 17 in the piston by means of holes 20 extending through the piston.
The cylinder 7 is provi-ded with a stem 21 mounted on the rearward end thereof and having a longitudinal passage 22 therein communicating with space 19 through an aligned hole 23. A conduit 24 is removably connecte-d to stem 21 for admitting fluid under pressure to the passage 22. The conduit 24 may be part of a syringe (not shown) or other source `of iluid under pressure. The iiow of uid supplied through conduit 24 is controlled by operation `of the syringe, when such is employed, or by a valve '24a when the conduit is connected to other source of uid under pressure.
A flexible ring or collar 25 of soft rubber or like material is arranged to be applied to the nose 12. The ring 25 has a tubular sleeve or neck 26 adapted to be seated on the nose 12 which preferably is provided with a recess 27, a radial annular tlange 2S projecting outwardly from the neck, and a peripheral rib 29 adapted to seat on 'the forward outer surface of the cylindrical body 7.
In operation, the operator applies his thumb to the stop lilato locate the piston in forward position, and a v collar 25 is applied to the nos-e 12, as shown in FIGURE 1. The nozzle 14 is then applied to the mouth of the blood vessel and fluid under pressure is -admitted to passage 22. The uid may be any iluid of sterile nature, such as a low pressure gas or saline solution as commonly used in surgical operations. The uid ows through passage 22, hole 23, space 19, hole or holes 20, passage 17, and emerges as a tine jet through nozzle orifice 13. Since the `diameter of the piston rod 15 is less than the interior diameter of the cylinder, the piston will be held in its forward position under Ili-ght load because of the iluid pressure in space 19.
The issuing tine jet opens the mouth of the vessel. Since the hemostatic clamp` produces a restriction in the blood vessel, further application of fluid under pressure and movement of the nose 12 into the vessel results in a return flow of fluid between the Vessel wall and the piston nose which expands the vessel and permits the end of the vessel to slide over the sleeve 26 of the collar 25. At this point, admission of fluid under pressure is arrested, thus removing pressure on the pist-on and permitting it to move freely. The everting operation is completed by moving the cylinder '7 towards the bushing, which causes the collar v2,5 to be turned inside out by engagement of the end edge 9a with the ange 29S of the collar. This action also everts the overlying portion of the blood vessel, as shown in FIGURE 2.
After the suturingY operation Ihas been completed, the flexible collar 25 is removed by tearing it apart. It will vbe appreciated that `a new collar 25 is employed for each operation.
The everting operation may be performed as described in a very short space of time and in a dependable and positive manner. Excessive pressure on the wall of the vessel between the end of the bushing and the nose of the piston is completely avoided. The everting device described is simple to manufacture, and is subject to convenient and effective washing and sterilization.
the everter will he chosen to correspond with the size of the lbushing employed in the suturing apparatus.
We claim:
1. A method of positioning the end'of a blood vessel on a suturing apparatus bushing which comprises'applying suction induced air dow to one end of said bushing while applying the other end of said bushing to the end of said blood vessel to draw said hlood Vessel end into said bushing, applying a jet of fluid to the mouth of said lblood vessel While in said bushing to expand said mouth, and while maintaining said mouth in expanded condition turning said end of sai-d blood vessel inside out upon the outside surface of said bushing.
2. A vascular everter comprising a cylinder of uniform inter-nal diameter having a closed end and a free end edge dening an open end, a piston reciprocally mounted in said cylinder and having a nose of smaller diameter than the internal diameter of said cylinder directed towards said open end and having a large` diameter portion engaging said cylinder, said large diameter portion having an end face contiguous with said nose and directed towards said open end, a nozzle axially arranged in said nose, and
a piston rod extending through said closed end, said cylinder having an annular space surrounding said piston rod, said piston rod having a passage therein communicating with said annular space and said nozzle, said nose projecting forwardly of saidcylinder in one position of said piston, means for admitting a controlled supply of` iluid under pressure to said annular space to produce a uid jet through said nozzle, and a flexible collar removably seated on said nose, said collar having a radially extending annular portion of a diameter greater than the internal diameter of said cylinder for engagement by said free end edge of said cylinder to turn said collar inside out on reciprocation of said cylinder relatively to said piston. Y Y
3. A vascular everter comprising a cylinder of uniform internal diameter having a closed end and a free end edge dening an open end, a piston reciproca-Hy mounted in said cylinder and having thereonra rearwardly extending piston rod, said piston having a forwardly projecting nozzle of smaller diameterrthan the internal diameter of said cylinder, and having a large diameter portion engaging said cylinder, said large diameter portion having an end face contiguous with said nozzle and directed towards said open end, a stop on the end of said piston rod engageable with said cylinder closed end to define a forward position of said piston, said nozzle projecting forwardly through said open end of said cylinder `when said piston is in said forward position, said cylinder having an annular space surrounding said piston rod, said piston having a passage therein communicating with said annular space and with said nozzle, means for admitting a controlled supply of fluid under pressure to said annular space and a flexible collar removably seated on said nozzle and having a radially extending annular portion of a diameter greater than the internal diameter of said cylinder for engagement hy said free end edge of said cylinder. 4. A vascular everter comprising ay cylinder of uniform internal diameter having a closed end and a free end edge defining an open end, a piston reciprocally mounted in said cylinder and having thereon a rearwardly extending piston rod, said piston having a forwardly projecting nozzle of smaller diameter than the internal diameter of said cylinder, and having a large diameter portion engaging said cylinder, said large diameter portion having an end face contiguous with said nozzle and directed towards said open end, a stop on the end of said piston rod engagea'ble with said cylinder closed end to define a forward position of said piston, said nozzle projecting forwardly through said open end of said cylinder when said piston is in said forward position, said cylinder having an annular space surrounding said piston rod, said piston having a passage therein communicating with said annular space and with said nozzle, and means for admitting a controlled supply of fluid under pressure to said annular space.
References Cited in the le of this patent UNITED STATES PATENTS 1,151,300 Soresi Aug. 24, 1915 2,399,112 Glover Apr. 23, 1946 4 2,453,056 zack Nev. 2, 194s 2,779,996 Tanis Feb..5, 1957 2,940,452 Smialowski V 4 June 14, 1960
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Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3180337A (en) * 1963-04-25 1965-04-27 Ca Nat Research Council Vascular everting device
US3280781A (en) * 1965-09-27 1966-10-25 Bunker Ramo Auto-pilot system
US3789847A (en) * 1971-08-19 1974-02-05 A Lehmann Tool for lower colon surgery
US3856018A (en) * 1973-02-26 1974-12-24 P Perisse Process for ligating sectioned blood vessels
US3856017A (en) * 1972-02-24 1974-12-24 A Chancholle Apparatus for ligating sectioned blood vessels
US4350160A (en) * 1979-11-14 1982-09-21 Kolesov Evgeny V Instrument for establishing vascular anastomoses
US4622970A (en) * 1985-08-29 1986-11-18 The Johns Hopkins University Vascular everting instrument
US5709335A (en) * 1994-06-17 1998-01-20 Heartport, Inc. Surgical stapling instrument and method thereof
US5732872A (en) * 1994-06-17 1998-03-31 Heartport, Inc. Surgical stapling instrument
US5817113A (en) * 1995-02-24 1998-10-06 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5881943A (en) * 1994-06-17 1999-03-16 Heartport, Inc. Surgical anastomosis apparatus and method thereof
US5954735A (en) * 1996-02-29 1999-09-21 Oticon A/S Method and anastomotic instrument for use when performing an end-to-side anastomosis
US5957938A (en) * 1997-02-05 1999-09-28 United States Surgical Corporation Tissue everting needle
US5976159A (en) * 1995-02-24 1999-11-02 Heartport, Inc. Surgical clips and methods for tissue approximation
US5976161A (en) * 1998-01-07 1999-11-02 University Of New Mexico Tissue everting apparatus and method
US6171321B1 (en) 1995-02-24 2001-01-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US20010001826A1 (en) * 1998-01-23 2001-05-24 Heartport, Inc. System for performing vascular anastomoses
US6280460B1 (en) 1998-02-13 2001-08-28 Heartport, Inc. Devices and methods for performing vascular anastomosis
US20030055441A1 (en) * 1997-10-24 2003-03-20 Suyker Wilhelmus Joseph Leonardus Mechanical anastomosis system for hollow structures
US6547799B2 (en) 2001-06-26 2003-04-15 Ethicon, Inc. Vessel eversion instrument with pressurizable membrane
US6562053B2 (en) 2001-05-21 2003-05-13 Ethicon, Inc. Curved mandrel for assisting vessel eversion
US6575985B2 (en) 2001-09-10 2003-06-10 Ethicon, Inc. Vessel eversion instrument with conical holder
US6589255B2 (en) 2001-06-28 2003-07-08 Ethicon, Inc. Vessel eversion instrument with filament elements
US20030191482A1 (en) * 1998-10-22 2003-10-09 Suyker Wilhelmus Joseph Leonardus Mechanical anastomosis system for hollow structures
US6712829B2 (en) 2001-09-10 2004-03-30 Ethicon, Inc. Vessel eversion instrument with conical, expandable mandrel
US20040092972A1 (en) * 2000-11-09 2004-05-13 Leonardus Suyker Wilhelmus Joseph Connector, applicator and method for mechanically connecting hollow structures, in particular small blood vessels, as well a auxiliary devices
US6776782B2 (en) 2001-06-26 2004-08-17 Ethicon, Inc. Vessel eversion instrument with wiping element
US20050055083A1 (en) * 2002-01-23 2005-03-10 Cardica, Inc. Poke-through tool
US20050267498A1 (en) * 2002-04-30 2005-12-01 Cardica, Inc. Tissue everting device and method
WO2007014482A1 (en) * 2005-08-03 2007-02-08 King Faisal Specialist Hospital & Research Centre, Mbc-03 Device for connecting hollow organs, especially blood vessels, by surgery
US20110178528A1 (en) * 2010-01-19 2011-07-21 Tyco Healthcare Group Lp Disposable circumcision device
US8781604B2 (en) 2004-08-18 2014-07-15 Cardiac Pacemakers, Inc. Method of implanting stimulation lead with biased curved section through the interatrial septum
WO2015024952A3 (en) * 2013-08-21 2015-07-02 King Faisal Specialist Hospital & Research Centre Device for connecting hollow organs, especially blood vessels, by surgery

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Cited By (86)

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Publication number Priority date Publication date Assignee Title
US3180337A (en) * 1963-04-25 1965-04-27 Ca Nat Research Council Vascular everting device
US3280781A (en) * 1965-09-27 1966-10-25 Bunker Ramo Auto-pilot system
US3789847A (en) * 1971-08-19 1974-02-05 A Lehmann Tool for lower colon surgery
US3856017A (en) * 1972-02-24 1974-12-24 A Chancholle Apparatus for ligating sectioned blood vessels
US3856018A (en) * 1973-02-26 1974-12-24 P Perisse Process for ligating sectioned blood vessels
US4350160A (en) * 1979-11-14 1982-09-21 Kolesov Evgeny V Instrument for establishing vascular anastomoses
US4622970A (en) * 1985-08-29 1986-11-18 The Johns Hopkins University Vascular everting instrument
US6588643B2 (en) 1994-06-17 2003-07-08 Hearport, Inc. Surgical stapling instrument and method thereof
US6450390B2 (en) 1994-06-17 2002-09-17 Hearport, Inc. Surgical anastomosis apparatus and method thereof
US6763993B2 (en) 1994-06-17 2004-07-20 Bolduc Lee R Surgical stapling instrument and method thereof
US5881943A (en) * 1994-06-17 1999-03-16 Heartport, Inc. Surgical anastomosis apparatus and method thereof
US5947363A (en) * 1994-06-17 1999-09-07 Heartport, Inc. Surgical stapling instrument and method thereof
US20040200876A1 (en) * 1994-06-17 2004-10-14 Bolduc Lee R. Surgical stapling instrument and method thereof
US5957363A (en) * 1994-06-17 1999-09-28 Elf Atochem S.A. Method of performing vascular anastomosis
US6659327B2 (en) 1994-06-17 2003-12-09 Heartport, Inc. Surgical anastomosis apparatus and method thereof
US6631837B1 (en) 1994-06-17 2003-10-14 Heartport, Inc. Surgical stapling instrument and method thereof
US5709335A (en) * 1994-06-17 1998-01-20 Heartport, Inc. Surgical stapling instrument and method thereof
US7122044B2 (en) 1994-06-17 2006-10-17 Heartport, Inc. Surgical stapling instrument and method thereof
US6209773B1 (en) 1994-06-17 2001-04-03 Heartport, Inc. Surgical stapling instrument and method thereof
US5732872A (en) * 1994-06-17 1998-03-31 Heartport, Inc. Surgical stapling instrument
US6491704B2 (en) 1995-02-24 2002-12-10 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US20040186490A1 (en) * 1995-02-24 2004-09-23 Gifford Hanson S. Devices and methods for performing avascular anastomosis
US6443965B1 (en) * 1995-02-24 2002-09-03 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US7935129B2 (en) 1995-02-24 2011-05-03 Heartport, Inc. Device for engaging tissue having a preexisting opening
US6451034B1 (en) 1995-02-24 2002-09-17 Gifford, Iii Hanson S. Devices and methods for performing a vascular anastomosis
US6461365B2 (en) 1995-02-24 2002-10-08 Heartport, Inc. Surgical clips and methods for tissue approximation
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