US3086530A - Surgical multiple puncture devices - Google Patents

Surgical multiple puncture devices Download PDF

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Publication number
US3086530A
US3086530A US857679A US85767959A US3086530A US 3086530 A US3086530 A US 3086530A US 857679 A US857679 A US 857679A US 85767959 A US85767959 A US 85767959A US 3086530 A US3086530 A US 3086530A
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block
needles
sleeve
guide plate
carrier block
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Expired - Lifetime
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US857679A
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Groom Walter
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Allen and Hanburys Ltd
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Allen and Hanburys Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices

Definitions

  • This invention relates to a surgical multiple puncture device, that is to say a device which can be used to puncture the skin of a patient in a number of places in a single operation.
  • the invention provides an improved such device comprising a body which is open at one end, a needle carrier block longitudinally slidable in the body, a plurality of needles for puncturing the skin of a patient, the said needles being removably secured in the block with their Working ends protruding from the block and the open end of the body, means for displacing the block and the needles carried by it in a working stroke in which the needles can puncture the skin of a patient, and means for adjustably limiting the depth which the needles can penetrate the skin of a patient.
  • FIGURE 1 is a sectional elevation of an embodiment of the invention
  • FIGURE 2 is an enlarged view of part of the device illustrated in FIGURE 1, and
  • FIGURE 3 is a section on line A-A of FIGURE 2.
  • a surgical multiple puncture device which is particularly useful as a tuberculin scarifier, comprises a cylindrical body or barrel 1 which has an open end formed with an inturned flange or rim 2 and is closed at the other end by a plug 3 which is screwed in the body 1 and can be removed to give access to the interior of the body.
  • the plug supports a finger grip 4 as well as closing the end of the body.
  • a cylindrical needle carrier block 5 has a sliding fit inside the body 1 and has one end portion of smaller diameter than the remainder of the block so that this smaller portion can be made to protrude from the open end of the body 1 by suitable longitudinal movement of the carrier block, such movement being limited by the engagement of the rim 2 at the open end of the body 1 with the larger portion of the carrier block 5.
  • the carrier block 5 has a plurality of longitudinal passages 6.
  • a needle 7 of length greater than the carrier block 5 is located in each of these passages 6 with its sharp or working end protruding from the block and the open end of the body 1.
  • the needles have cylindrical heads 8 which fit on the inner surface of the block 5 to prevent movement of the needles relative to the block in the outward direction.
  • the needles 7 are held against inward movement relative to the block 5 by the head of a needleretaining screw 9 which screws into the block.
  • the passages 6 can have countersunk recessed inner ends and the needles 7 can have frustoconical heads located in their recesses so as to be flush with the inner end face of the block.
  • Sleeve 12 is rotatably positioned on the outer surface of the cylindrical body 1, and a helical slot 13 as seen in FIGS. 2 and 3 is formed through the wall of the body.
  • the larger portion of the needle carrier block 5 has a radial bore 10 formed therein.
  • a screw pin 11 is threaded into a suitable threaded aperture in sleeve 12 and extends radially inwardly through the helical slot in the body, and the inner end of the screw pin fits loosely within the bore 10 of the carrier block 5. Accordingly,
  • a guide plate 14 is positioned outwards of the open end of the body 1 and is adapted to be placed on the skin of a patient.
  • This guide plate 14 is provided with a plurality of holes 15 at least equal in number to the number of needles 7 and so positioned that the working ends of the needles 7 can pass through them into the skin of the patient.
  • the guide plate is supported by arms 16 fixed to the rotatable sleeve 12 so that rotation of the sleeve alters the longitudinal and angular positions of the guide plate with respect to the body.
  • a second screw pin 17 is mounted in the sleeve 12 opposite the pin 11 and is movable in a helical slot 18 in the body 1.
  • a return plunger 19 fixed to the guide plate 14 and loaded by a spring 20 is movable in an axial bore in the carrier block 5 and urges the carrier block in the inward direction.
  • the amount by which the needles can penetrate the skin depends on the position of the guide plate 14 relative to the body 1 at the commencement of the operation and this in turn depends on the angular position of the sleeve 12 on the body.
  • Means can be provided for positively locating the sleeve in any one of a number of desired positions.
  • a spring-loaded pin carried by the sleeve can engage in any one of a number of recesses in the body.
  • An operating mechanism indicated generally by reference numeral 21 is provided for urging the carrier block and needle 7 outward in a Working stroke.
  • This operating mechanism includes a striker rod 22 which engages the head of retaining screw 9. It will be understood that the operating mechanism may be of any typical conventional and well-known construction and does not form a part of the present invention.
  • the sleeve 12 When utilizing the device, the sleeve 12 is rotatably adjusted with respect to body 1, whereby pins 11 and 17 moving in the respective slots 13- and 18 will cause the sleeve 12 to be shifted axially with respect to body 1.
  • Sleeve 12 carries the guide plate '14 through the intermediary of arms 16 whereby longitudinal shifting of the sleeve will cause the guide plate 14 to be shifted axially with respect to body 1.
  • the amount of axial shifting of guide plate 14 will serve to adjust the amount of penetration of the needles into the skin of a patient.
  • the carrier block 5 is also rotated in unison with sleeve 12 through the intermediary of pin 11, pin 11 in its associated slot 10 allowing relative movement of the pin with respect to the block. Since the carrier block and the needles are rotated along with sleeve 12 and guide plate 14, this ensures that the needles will always be aligned with the slots in the guide plate so that the needles may freely pass through the guide plate to penetrate the skin of a patient.
  • a surgical multiple puncture device comprising a substantially cylindrical hollow body having an inturned flange at one thereof, said flange defining a central opening at said end of the body, a removable plug secured in the opposite end of said body, a substantially cylindrigal needle carrier block slidably fitted Within said body and having an enlarged portion which is of greater diameter than the central opening in said one end of the body and including a smaller portion which is movable through said open end of the body, movement of said block in an outward direction being limited by engagement of the enlarged portion of the block with said inturned flange on the body, said block having a plurality of passages extending longitudinally therethrough, needles positioned within said passages with the sharp Working end of the needles protruding from the block and the open end of the body, said needles each having an enlarged head formed thereon of greater diameter than the passages in said block for limiting outward movement of the needles relative to the block, needle retaining screw means detachably secured to said block and engaging said enlarged heads of

Description

April 23, 1963 w. GROOM 3,086,530
SURGICAL MULTIPLE PUNCTURE DEVICES Filed Dec. 7, 1959 2 Sheets-Sheet 1 INVENTOR yaw BY M ATTORNEY April 23, 1963 w. GROOM SURGICAL MULTIPLE PUNCTURE DEVICES 2 Sheets-Sheet 2 Filed Dec. 7, 1959 FIG.3
INVENTOR ATTORNEY United States Patent SURGICAL MULTIPLE PUNCTURE DEVICES Walter Groom, Colindale, England, assignor to Allen &
Hanburys Limited, London, England, a company of Great Britain Filed Dec. 7, 1959, Ser. No. 857,679 Claims priority, application Great Britain Dec. 10, 1958 1 Claim. (Cl. 128329) This invention relates to a surgical multiple puncture device, that is to say a device which can be used to puncture the skin of a patient in a number of places in a single operation.
The invention provides an improved such device comprising a body which is open at one end, a needle carrier block longitudinally slidable in the body, a plurality of needles for puncturing the skin of a patient, the said needles being removably secured in the block with their Working ends protruding from the block and the open end of the body, means for displacing the block and the needles carried by it in a working stroke in which the needles can puncture the skin of a patient, and means for adjustably limiting the depth which the needles can penetrate the skin of a patient.
In the accompanying drawings:
FIGURE 1 is a sectional elevation of an embodiment of the invention,
FIGURE 2 is an enlarged view of part of the device illustrated in FIGURE 1, and
FIGURE 3 is a section on line A-A of FIGURE 2.
In the illustrated embodiment of the invention, a surgical multiple puncture device, which is particularly useful as a tuberculin scarifier, comprises a cylindrical body or barrel 1 which has an open end formed with an inturned flange or rim 2 and is closed at the other end by a plug 3 which is screwed in the body 1 and can be removed to give access to the interior of the body. The plug supports a finger grip 4 as well as closing the end of the body.
A cylindrical needle carrier block 5 has a sliding fit inside the body 1 and has one end portion of smaller diameter than the remainder of the block so that this smaller portion can be made to protrude from the open end of the body 1 by suitable longitudinal movement of the carrier block, such movement being limited by the engagement of the rim 2 at the open end of the body 1 with the larger portion of the carrier block 5. The carrier block 5 has a plurality of longitudinal passages 6. A needle 7 of length greater than the carrier block 5 is located in each of these passages 6 with its sharp or working end protruding from the block and the open end of the body 1. The needles have cylindrical heads 8 which fit on the inner surface of the block 5 to prevent movement of the needles relative to the block in the outward direction. The needles 7 are held against inward movement relative to the block 5 by the head of a needleretaining screw 9 which screws into the block.
Alternatively, the passages 6 can have countersunk recessed inner ends and the needles 7 can have frustoconical heads located in their recesses so as to be flush with the inner end face of the block.
Sleeve 12 is rotatably positioned on the outer surface of the cylindrical body 1, and a helical slot 13 as seen in FIGS. 2 and 3 is formed through the wall of the body. The larger portion of the needle carrier block 5 has a radial bore 10 formed therein. A screw pin 11 is threaded into a suitable threaded aperture in sleeve 12 and extends radially inwardly through the helical slot in the body, and the inner end of the screw pin fits loosely within the bore 10 of the carrier block 5. Accordingly,
"ice
rotation of sleeve 12 with respect to body 1 will cause the sleeve to move longitudinally with respect to the body, and at the same time carrier block 5 will turn with the sleeve due to the interconnection between the sleeve and the carrier block through the pin 11.
A guide plate 14 is positioned outwards of the open end of the body 1 and is adapted to be placed on the skin of a patient. This guide plate 14 is provided with a plurality of holes 15 at least equal in number to the number of needles 7 and so positioned that the working ends of the needles 7 can pass through them into the skin of the patient. The guide plate is supported by arms 16 fixed to the rotatable sleeve 12 so that rotation of the sleeve alters the longitudinal and angular positions of the guide plate with respect to the body. A second screw pin 17 is mounted in the sleeve 12 opposite the pin 11 and is movable in a helical slot 18 in the body 1. A return plunger 19 fixed to the guide plate 14 and loaded by a spring 20 is movable in an axial bore in the carrier block 5 and urges the carrier block in the inward direction.
The amount by which the needles can penetrate the skin depends on the position of the guide plate 14 relative to the body 1 at the commencement of the operation and this in turn depends on the angular position of the sleeve 12 on the body. Means can be provided for positively locating the sleeve in any one of a number of desired positions. For example, a spring-loaded pin carried by the sleeve can engage in any one of a number of recesses in the body. An operating mechanism indicated generally by reference numeral 21 is provided for urging the carrier block and needle 7 outward in a Working stroke. This operating mechanism includes a striker rod 22 which engages the head of retaining screw 9. It will be understood that the operating mechanism may be of any typical conventional and well-known construction and does not form a part of the present invention. After the working stroke has been completed, the needle carrier block is returned to its initial position under the influence of spring 20.
When utilizing the device, the sleeve 12 is rotatably adjusted with respect to body 1, whereby pins 11 and 17 moving in the respective slots 13- and 18 will cause the sleeve 12 to be shifted axially with respect to body 1. Sleeve 12 carries the guide plate '14 through the intermediary of arms 16 whereby longitudinal shifting of the sleeve will cause the guide plate 14 to be shifted axially with respect to body 1. The amount of axial shifting of guide plate 14 will serve to adjust the amount of penetration of the needles into the skin of a patient. As sleeve 12 is rotated to obtain such axial adjustment, the carrier block 5 is also rotated in unison with sleeve 12 through the intermediary of pin 11, pin 11 in its associated slot 10 allowing relative movement of the pin with respect to the block. Since the carrier block and the needles are rotated along with sleeve 12 and guide plate 14, this ensures that the needles will always be aligned with the slots in the guide plate so that the needles may freely pass through the guide plate to penetrate the skin of a patient.
What I claim is:
A surgical multiple puncture device comprising a substantially cylindrical hollow body having an inturned flange at one thereof, said flange defining a central opening at said end of the body, a removable plug secured in the opposite end of said body, a substantially cylindrigal needle carrier block slidably fitted Within said body and having an enlarged portion which is of greater diameter than the central opening in said one end of the body and including a smaller portion which is movable through said open end of the body, movement of said block in an outward direction being limited by engagement of the enlarged portion of the block with said inturned flange on the body, said block having a plurality of passages extending longitudinally therethrough, needles positioned within said passages with the sharp Working end of the needles protruding from the block and the open end of the body, said needles each having an enlarged head formed thereon of greater diameter than the passages in said block for limiting outward movement of the needles relative to the block, needle retaining screw means detachably secured to said block and engaging said enlarged heads of the needles for limiting inward movement of the needles relative to the block, said needle retaining screw means being positioned for engagement with said plug, said body having a helical slot formed therethrough, a sleeve rotatably positioned about said body, pin means operatively connected with said sleeve and extending through said helical slot in the body, said block having a radially extending bore which receives the inner end of said pin means whereby rotation of said sleeve also produces rotation of said block, guide plate means positioned outwardly of the open end of the body, said guide plate means having a plurality of holes formed therethrough at least equal in number to the number of needles supported by said block and so positioned that the Working end of the needles can pass through the holes in the guide plate, said guide plate being supported by said rotatable sleeve so that rotation of the sleeve alters not only the angular and longitudinal position of the sleeve, but also the angular and longitudinal position of the guide plate with respect to the body, and resilient means for urging said block continuously in an inward direction so as to retract said needles, and means for moving said block and said needles outwardly in a working stroke in which said needles can puncture the skin of the patient.
References Cited in the file of this patent FOREIGN PATENTS
US857679A 1958-12-10 1959-12-07 Surgical multiple puncture devices Expired - Lifetime US3086530A (en)

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GB39893/58A GB885036A (en) 1958-12-10 1958-12-10 Improvements relating to surgical multiple puncture devices

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Cited By (47)

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US3451490A (en) * 1967-11-22 1969-06-24 Aro Corp Power tool adjustment device
US3612051A (en) * 1968-07-24 1971-10-12 Raul Olvera Arce Hypodermic syringe applicating device
DE2259229A1 (en) * 1972-12-04 1974-06-06 Georg Kirchner NEEDLE APPARATUS FOR MEDICAL PURPOSES
US4167179A (en) * 1977-10-17 1979-09-11 Mark Kirsch Planar radioactive seed implanter
US4462405A (en) * 1982-09-27 1984-07-31 Ehrlich Joseph C Blood letting apparatus
US4469110A (en) * 1981-06-25 1984-09-04 Slama Gerard J Device for causing a pinprick to obtain and to test a drop of blood
US4586490A (en) * 1984-02-27 1986-05-06 Katz Harry R Needle inserting instrument means for interstitial radiotherapy
WO1993022971A1 (en) * 1992-05-11 1993-11-25 Boston Scientific Corporation Multiple needle biopsy instrument
US5380279A (en) * 1994-03-11 1995-01-10 The Upjohn Company Animal vaccination gun
US5618295A (en) * 1993-10-16 1997-04-08 Samsung Electro-Mechanics Co., Ltd. Apparatus for preparing skin in advance
US5843114A (en) * 1994-05-23 1998-12-01 Samsung Electro-Mechanics Co., Ltd. Skin perforating apparatus for transdermal medication
US6030404A (en) * 1997-09-06 2000-02-29 Lawson; Alexis A. Skin penetration apparatus including multiple needle configuration
US6334856B1 (en) 1998-06-10 2002-01-01 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US20020082543A1 (en) * 2000-12-14 2002-06-27 Jung-Hwan Park Microneedle devices and production thereof
US6412384B1 (en) * 1999-03-23 2002-07-02 Shin Iwao Hole-forming device
US20020138049A1 (en) * 1998-06-10 2002-09-26 Allen Mark G. Microneedle devices and methods of manufacture and use thereof
US20030095582A1 (en) * 2000-12-21 2003-05-22 Ackley Donald E. Microneedle array systems
US20030135167A1 (en) * 2001-09-19 2003-07-17 Gonnelli Robert R. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US20030135158A1 (en) * 2001-09-21 2003-07-17 Gonnelli Robert R. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US20030220610A1 (en) * 2002-02-04 2003-11-27 Becton Dickinson And Company Device and method for delivering or withdrawing a substance through the skin
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
AU2003296884B2 (en) * 2002-07-22 2009-07-16 Becton, Dickinson And Company Patch-like infusion device
US20090326571A1 (en) * 2005-12-22 2009-12-31 Spamedica International Srl Skin rejuvination resurfacing device
DE102008030894A1 (en) * 2008-06-30 2010-01-07 Liebl, Edelgard, Zelsheim Hautpunktierungsstempel
US7670352B1 (en) 2004-03-24 2010-03-02 Caribbean Medical Brokers, Inc. Adjustable tip with integrated detent for blood lancet system
US20100217202A1 (en) * 2009-02-21 2010-08-26 Clark Timothy W I Device for achieving hemostasis at site of puncture wound
US20110196417A1 (en) * 2009-02-21 2011-08-11 Clark Timothy W I Device for achieving hemostasis
US20120046663A1 (en) * 2010-08-17 2012-02-23 Warsaw Orthopedic, Inc. Bone scoring device
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
US10265477B2 (en) 2013-05-23 2019-04-23 Allergan, Inc. Mechanical syringe accessory
US10433928B2 (en) 2015-03-10 2019-10-08 Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company Multiple needle injector
USD865950S1 (en) 2017-03-24 2019-11-05 Allergan, Inc. Syringe device
US10596321B2 (en) 2016-04-08 2020-03-24 Allergan, Inc. Aspiration and injection device
WO2020097244A1 (en) * 2018-11-07 2020-05-14 Cytrellis Biosystems, Inc. Systems and methods for skin treatment
US10792427B2 (en) 2014-05-13 2020-10-06 Allergan, Inc. High force injection devices
US10953143B2 (en) 2013-12-19 2021-03-23 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
US11166743B2 (en) 2016-03-29 2021-11-09 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
US11207076B2 (en) 2018-03-16 2021-12-28 Forge Medical, Inc. Locking mechanism for hemostasis device
US11324534B2 (en) 2014-11-14 2022-05-10 Cytrellis Biosystems, Inc. Devices and methods for ablation of the skin
US11464954B2 (en) 2016-09-21 2022-10-11 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
US11517323B2 (en) 2016-07-06 2022-12-06 Forge Medical, Inc. Adhesive pad and hemostasis system
US11534344B2 (en) 2013-02-20 2022-12-27 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
US11684719B2 (en) 2013-05-23 2023-06-27 Allergan, Inc. Methods of treatment using a syringe extrusion accessory

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Cited By (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451490A (en) * 1967-11-22 1969-06-24 Aro Corp Power tool adjustment device
US3612051A (en) * 1968-07-24 1971-10-12 Raul Olvera Arce Hypodermic syringe applicating device
DE2259229A1 (en) * 1972-12-04 1974-06-06 Georg Kirchner NEEDLE APPARATUS FOR MEDICAL PURPOSES
US4167179A (en) * 1977-10-17 1979-09-11 Mark Kirsch Planar radioactive seed implanter
US4469110A (en) * 1981-06-25 1984-09-04 Slama Gerard J Device for causing a pinprick to obtain and to test a drop of blood
US4462405A (en) * 1982-09-27 1984-07-31 Ehrlich Joseph C Blood letting apparatus
US4586490A (en) * 1984-02-27 1986-05-06 Katz Harry R Needle inserting instrument means for interstitial radiotherapy
WO1993022971A1 (en) * 1992-05-11 1993-11-25 Boston Scientific Corporation Multiple needle biopsy instrument
US5415182A (en) * 1992-05-11 1995-05-16 Boston Scientific Corporation Multiple needle biopsy instrument
US5618295A (en) * 1993-10-16 1997-04-08 Samsung Electro-Mechanics Co., Ltd. Apparatus for preparing skin in advance
US5380279A (en) * 1994-03-11 1995-01-10 The Upjohn Company Animal vaccination gun
US5843114A (en) * 1994-05-23 1998-12-01 Samsung Electro-Mechanics Co., Ltd. Skin perforating apparatus for transdermal medication
US6030404A (en) * 1997-09-06 2000-02-29 Lawson; Alexis A. Skin penetration apparatus including multiple needle configuration
US20020138049A1 (en) * 1998-06-10 2002-09-26 Allen Mark G. Microneedle devices and methods of manufacture and use thereof
US8708966B2 (en) 1998-06-10 2014-04-29 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6334856B1 (en) 1998-06-10 2002-01-01 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US20100312191A1 (en) * 1998-06-10 2010-12-09 Georgia Tech Research Corporation Microneedle Devices and Methods of Manufacture and Use Thereof
US6629483B2 (en) 1999-03-23 2003-10-07 Shin Iwao Hole-forming device
US6412384B1 (en) * 1999-03-23 2002-07-02 Shin Iwao Hole-forming device
US8257324B2 (en) 1999-06-04 2012-09-04 Georgia Tech Research Corporation Microneedle drug delivery device
US7226439B2 (en) 1999-06-04 2007-06-05 Georgia Tech Research Corporation Microneedle drug delivery device
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US20070225676A1 (en) * 1999-06-04 2007-09-27 Prausnitz Mark R Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US20050137531A1 (en) * 1999-11-23 2005-06-23 Prausnitz Mark R. Devices and methods for enhanced microneedle penetration of biological barriers
US9302903B2 (en) 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US20020082543A1 (en) * 2000-12-14 2002-06-27 Jung-Hwan Park Microneedle devices and production thereof
US20030095582A1 (en) * 2000-12-21 2003-05-22 Ackley Donald E. Microneedle array systems
US7027478B2 (en) 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US8361037B2 (en) 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135167A1 (en) * 2001-09-19 2003-07-17 Gonnelli Robert R. Microneedles, microneedle arrays, and systems and methods relating to same
US8920375B2 (en) 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20030135158A1 (en) * 2001-09-21 2003-07-17 Gonnelli Robert R. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20090062752A1 (en) * 2001-09-28 2009-03-05 Gonnelli Robert R Switchcable microneedle arrays and systems and methods relating to same
US20090043250A1 (en) * 2001-09-28 2009-02-12 Gonnelli Robert R Microneedle with membrane
US20050137536A1 (en) * 2001-09-28 2005-06-23 Gonnelli Robert R. Microneedle with membrane
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US6808506B2 (en) * 2002-02-04 2004-10-26 Becton, Dickinson And Company Device and method for delivering or withdrawing a substance through the skin
US7083592B2 (en) * 2002-02-04 2006-08-01 Becton Dickinson And Company Device and method for delivering withdrawing a substance through the skin
US20030220610A1 (en) * 2002-02-04 2003-11-27 Becton Dickinson And Company Device and method for delivering or withdrawing a substance through the skin
US20050049571A1 (en) * 2002-02-04 2005-03-03 Becton, Dickinson And Company Device and method for delivering or withdrawing a substance through the skin
KR101020724B1 (en) 2002-02-04 2011-03-09 벡톤 디킨슨 앤드 컴퍼니 Device and method for delivering or withdrawing a substance through the skin
WO2003066126A3 (en) * 2002-02-04 2004-08-05 Becton Dickinson Co Dermal access member
AU2003296884B2 (en) * 2002-07-22 2009-07-16 Becton, Dickinson And Company Patch-like infusion device
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GB885036A (en) 1961-12-20
FR1242174A (en) 1960-09-23
DE1863283U (en) 1962-12-06

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