US3110308A - Parenteral fluid administration equiment - Google Patents
Parenteral fluid administration equiment Download PDFInfo
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- US3110308A US3110308A US63923A US6392360A US3110308A US 3110308 A US3110308 A US 3110308A US 63923 A US63923 A US 63923A US 6392360 A US6392360 A US 6392360A US 3110308 A US3110308 A US 3110308A
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- tubing
- cannula
- container
- blood
- membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
Definitions
- the present invention relates to parenteral fluid administration equipment. More particularly, it relates to an externally manipulable, internally located valve system especially useful in the parenteral fluid administration field.
- Resilient tubing such as plastic and rubber tubing finds wide usage in the parenteral fluid administration field.
- One such use is in the recently introduced multicontainer blood collection and administration system, in which resilient tubing is used both as a conduit for the blood from the patient to a first blood collection chamber and as a conduit for blood from the first container to other containers or anti-coagulant from secondary to primary container.
- the multi-chambered blood systems among other functions permit the conservation of whole blood, for example, by allowing, if desired, the division of a single pint of blood into pediatric quantities to be used individually or by allowing, if desired, the holding of the whole blood unadulterated by long term anticoagulants in the first container for the maximum period of time and then transferring the blood to a second chamber containing anticoagulants to extend the storage period.
- the closed multi-container blood systems depend largely for their elfectiveness upon the use of a positive off type valve or clamp which prevents the flow of the blood through the tubing from the first to the second container.
- valves or clamps may be used to more or less positively shut off the flow of fluids such as blood through the resilient tubing, the use of such valves is always accompanied by the risk of dislodgment, etc., and damage to the tubing itself.
- FIGURE 1 is an assembly view of a multi-container blood system showing the novel valve system of the present invention in pre-use condition.
- FIGURE 2 is a sectional view in larger scale of the novel valve system.
- FIGURE 1 a multi-container blood collecting and storing means having a flexible donor tube 11.
- the tube 11 provides at its outer end a phlebotomy needle 12 which is specially sharpened to minimize tissue trauma.
- the needle 12 is equipped with a protective sheath or cover 13 to protect against dulling and contamination.
- the container is preferably formed by juxtaposing sheets of thermoplastic material and heat sealing them along the edges.
- the donor tube 11 is sealed through the end 14 of the bag as is the port assembly and closure 15.
- the multi-container blood system further comprises as a transfer or storage means, a second flexible container 29 which is similar in form and construction to container it) and which is integrally joined thereto by connector tubing 21 of suitable length.
- the tube 21 is provided with an internal cannula 22 of steel, plastic or the like which is proportioned to fit in and move easily within the connecting tube.
- the tube 21 is removably closed adjacent container 10 by a transverse membrane 23 which is removed by external manipulation of the cannula 22 which is seen as having a sharpened beveled or pointed end 24 for this purpose.
- the cannula 22 is preferably coated or otherwise treated to present a hemorepellant surface. It may, if desired, also be provided with a flange or rounded butt end opposite its pointed end to make it more readily manipulable without damaging the tubing.
- FIGURE 2 the pointed cannula and puncturable transverse membrane are shown prior to use, enlarged and in greater detail.
- the protective sheath is removed -from the phlebotomy needle 12 and the vein of the donor punctured. The donation is then collected into the first container and collection ceased. If only a small portion of the blood is to be given initially or if after maxi-mum storage without an anticoagulant or with a short term anticoagulant it is desired to add an anticoagulant to the blood, the cannula is manipulated as for example, by compressing the tubing adjacent the blunt end of the cannula and collapsing the tubing thus forcing the cannula into puncturing relationship with the diaphragm, at which time the blood may be allowed to flow from the first to the second container.
- the second container may, of course, be of different size and/or contain an anticoagulant if so desired.
- novel inline cannula-membrane valve system described in detail above in connection with parenteral fluid administration equipment may of course be advantageously used in other fields to overcome the problem of retaining completely separate two or more solutions and yet preserving the possibility of combining them simply and easily if so desired.
- a donor tube having needle means at one end and communicating with a flexible, collapsible, hemo-repellant blood container at the other end, a length of resilient tubing connecting said container to a second flexible, collapsible container to form a unitary system, a removable, transverse membrane positively closing said connecting tubing to the flow of fluid between said containers and a free moving membrane-removing, hollow cannula located wholly within said tubing, the cannula being completely unattached to said tubing and any part of said system, said cannula being proportioned :to readily fit in and move within said tubing so that the cannula can be externally manipulated to remove said membrane without opening said tubing, said cannula being further manipulatable substantially out of said tubing into one of said containers.
- an improved removable closing means for controlling flow between said containers which means provides initially for a complete and positive obstruction to flow through said tubing and between said containers, and upon removal for a substantially and unobstructed flow through said tubing, said means comprising a removable transverse membrane barrier positively closing said connecting tubing to flow and a free moving membrane piercing cannula proportioned to fit in and freely move within said tubing, said cannula being completely unattached to said tubing and any part of said system so that it can be manipulated from outside said tubing to substantially remove said membrane and then may be further manipulated substantially out of said tubing into one of said containers so that flow through said tubing is substantially unobstructed and non-turbulent.
- a multi-container system for the conditioning and handling of blood comprised of at least two flexible, collapsible, hemo-repellant sterile blood containers, each having a blood inlet and an outlet, a length of resilient tubing connecting said flexible containers, a transverse membrane positively closing said tubing to flow and preventing flow between the containers joined by said tubing and a free moving membrane removing member located wholly within said tubing, said membrane removing member being completely unattached to said tubing and being so proportioned as to fit in and move freely Within said tubing so that it can be externally manipulated without opening said tubing to remove said membrane and may further be manipulated substantially out of said tubing into one of said containers so that flow through said tubing and between said containers is substantially unobstructed and non-turbulent.
- a multi-container closed system for the storage and handling of blood which system comprises at least two flexible, collapsible hemo-repellant containers joined together by a length of resilient connecting tubing, at
- said containers containing a substance which it is desired to isolate in said container, an improved means for preventing flow through said tubing and among said containers, and isolating said substance in said container, the improved means of preventing flow providing for positive closing of said tubing to flow, and comprising a removable transverse membrane completely closing said connecting tubing to fluid flow and a free moving, membrane piercing hollow cannula located wholly within said tubing, the cannula being completely unattached to said tubing and any part of said system, said cannula being proportioned to readily fit in and freely move within said tubing so that the cannula can be externally manipulated from without said system to substantially remove said membrane as an obstacle to fluid flow Without opening said closed system and thus allow for the introduction into another container of the system of the previously isolated substance.
Description
Nov. 12, 1963 D. BELLAMY, JR 3,110,30g
PARENTERAL FLUID ADMINISTRATION EQUIPMENT Filed Oct. 20, 1960 INVEN TOR.
DAVID BELLAMY JR.
BY M @W ATTORNEY United States Patent Ofltice 3,1 19,368 Patented Nov; 12, 1963 3,110,308 PARENTERAL FLUID ADMINISTRATIUN EQUEMENT David Bellamy, Jan, Framingham, Mass, assignor to Baxter Laboratories, Inc, Morton Grove, 11]., a corporation of Delaware Filed Oct. 20, 1960, Ser. No. 63,923 4 Claims. (Cl. 128-214) The present invention relates to parenteral fluid administration equipment. More particularly, it relates to an externally manipulable, internally located valve system especially useful in the parenteral fluid administration field.
Resilient tubing, such as plastic and rubber tubing finds wide usage in the parenteral fluid administration field. One such use is in the recently introduced multicontainer blood collection and administration system, in which resilient tubing is used both as a conduit for the blood from the patient to a first blood collection chamber and as a conduit for blood from the first container to other containers or anti-coagulant from secondary to primary container. The multi-chambered blood systems among other functions permit the conservation of whole blood, for example, by allowing, if desired, the division of a single pint of blood into pediatric quantities to be used individually or by allowing, if desired, the holding of the whole blood unadulterated by long term anticoagulants in the first container for the maximum period of time and then transferring the blood to a second chamber containing anticoagulants to extend the storage period. The closed multi-container blood systems depend largely for their elfectiveness upon the use of a positive off type valve or clamp which prevents the flow of the blood through the tubing from the first to the second container.
While many externally located valves or clamps may be used to more or less positively shut off the flow of fluids such as blood through the resilient tubing, the use of such valves is always accompanied by the risk of dislodgment, etc., and damage to the tubing itself.
It is therefore an object of the present invention to disclose a novel externally manipulable, internally located valve system for use in resilient tubing which is not accompanied by the aforesaid disadvantages.
It is further an object to disclose a closed multi-container blood system embodying the novel valve system of the present invention.
These and still other objects will become more apparent from the following description and drawing in which like reference characters denote like parts throughout the several views.
FIGURE 1 is an assembly view of a multi-container blood system showing the novel valve system of the present invention in pre-use condition.
FIGURE 2 is a sectional view in larger scale of the novel valve system.
In the exemplary form of the drawing, FIGURE 1, is shown a multi-container blood collecting and storing means having a flexible donor tube 11. The tube 11 provides at its outer end a phlebotomy needle 12 which is specially sharpened to minimize tissue trauma. The needle 12 is equipped with a protective sheath or cover 13 to protect against dulling and contamination.
The container is preferably formed by juxtaposing sheets of thermoplastic material and heat sealing them along the edges. The donor tube 11 is sealed through the end 14 of the bag as is the port assembly and closure 15.
The multi-container blood system further comprises as a transfer or storage means, a second flexible container 29 which is similar in form and construction to container it) and which is integrally joined thereto by connector tubing 21 of suitable length. In accordance with the present invention the tube 21 is provided with an internal cannula 22 of steel, plastic or the like which is proportioned to fit in and move easily within the connecting tube. The tube 21 is removably closed adjacent container 10 by a transverse membrane 23 which is removed by external manipulation of the cannula 22 which is seen as having a sharpened beveled or pointed end 24 for this purpose.
The cannula 22 is preferably coated or otherwise treated to present a hemorepellant surface. It may, if desired, also be provided with a flange or rounded butt end opposite its pointed end to make it more readily manipulable without damaging the tubing.
In FIGURE 2 the pointed cannula and puncturable transverse membrane are shown prior to use, enlarged and in greater detail.
In the obtaining and storage of the blood ultilizing the above described apparatus, the protective sheath is removed -from the phlebotomy needle 12 and the vein of the donor punctured. The donation is then collected into the first container and collection ceased. If only a small portion of the blood is to be given initially or if after maxi-mum storage without an anticoagulant or with a short term anticoagulant it is desired to add an anticoagulant to the blood, the cannula is manipulated as for example, by compressing the tubing adjacent the blunt end of the cannula and collapsing the tubing thus forcing the cannula into puncturing relationship with the diaphragm, at which time the blood may be allowed to flow from the first to the second container. The second container may, of course, be of different size and/or contain an anticoagulant if so desired.
The novel inline cannula-membrane valve system described in detail above in connection with parenteral fluid administration equipment may of course be advantageously used in other fields to overcome the problem of retaining completely separate two or more solutions and yet preserving the possibility of combining them simply and easily if so desired.
While an embodiment has been described in which a single tube with an integral transverse membrane and a steel cannula are employed, it is readily apparent that a membrane present at the junction of two lengths of tubing or a rigid or semi-rigid plastic cannula 'or the like may also be used without departing from the spirit or scope of the present invention.
The embodiments of the invention in which an exclusive property or privilege is claimed are as follows:
1. In parenteral fluid administration equipment a donor tube having needle means at one end and communicating with a flexible, collapsible, hemo-repellant blood container at the other end, a length of resilient tubing connecting said container to a second flexible, collapsible container to form a unitary system, a removable, transverse membrane positively closing said connecting tubing to the flow of fluid between said containers and a free moving membrane-removing, hollow cannula located wholly within said tubing, the cannula being completely unattached to said tubing and any part of said system, said cannula being proportioned :to readily fit in and move within said tubing so that the cannula can be externally manipulated to remove said membrane without opening said tubing, said cannula being further manipulatable substantially out of said tubing into one of said containers.
2. In a multi-container closed system for handling blood comprising at least two flexible, collapsible, hemorepellant sterile blood containers joined together by lengths of resilient connecting tubing, an improved removable closing means for controlling flow between said containers which means provides initially for a complete and positive obstruction to flow through said tubing and between said containers, and upon removal for a substantially and unobstructed flow through said tubing, said means comprising a removable transverse membrane barrier positively closing said connecting tubing to flow and a free moving membrane piercing cannula proportioned to fit in and freely move within said tubing, said cannula being completely unattached to said tubing and any part of said system so that it can be manipulated from outside said tubing to substantially remove said membrane and then may be further manipulated substantially out of said tubing into one of said containers so that flow through said tubing is substantially unobstructed and non-turbulent.
3. :In a multi-container system for the conditioning and handling of blood comprised of at least two flexible, collapsible, hemo-repellant sterile blood containers, each having a blood inlet and an outlet, a length of resilient tubing connecting said flexible containers, a transverse membrane positively closing said tubing to flow and preventing flow between the containers joined by said tubing and a free moving membrane removing member located wholly within said tubing, said membrane removing member being completely unattached to said tubing and being so proportioned as to fit in and move freely Within said tubing so that it can be externally manipulated without opening said tubing to remove said membrane and may further be manipulated substantially out of said tubing into one of said containers so that flow through said tubing and between said containers is substantially unobstructed and non-turbulent.
4. In a multi-container closed system for the storage and handling of blood, which system comprises at least two flexible, collapsible hemo-repellant containers joined together by a length of resilient connecting tubing, at
least one of said containers containing a substance which it is desired to isolate in said container, an improved means for preventing flow through said tubing and among said containers, and isolating said substance in said container, the improved means of preventing flow providing for positive closing of said tubing to flow, and comprising a removable transverse membrane completely closing said connecting tubing to fluid flow and a free moving, membrane piercing hollow cannula located wholly within said tubing, the cannula being completely unattached to said tubing and any part of said system, said cannula being proportioned to readily fit in and freely move within said tubing so that the cannula can be externally manipulated from without said system to substantially remove said membrane as an obstacle to fluid flow Without opening said closed system and thus allow for the introduction into another container of the system of the previously isolated substance.
tion of Blood Components, from Bibieotheca Haematologica (Basel), vol. 7, Jan. 20, 1958 (copy in Div.
Earl et al.: A Practical Method for the Aseptic Preparation of Human Platelet Concentrates With-out Loss of Other Blood Elements/f from New England Journal of Medicine, 254:l1321133, June 14, 1956.
Claims (1)
1. IN PARENTERAL FLUID ADMINISTRATION EQUIPMENT A DONOR TUBE HAVING NEEDLE MEANS AT ONE END AND COMMUNICATING WITH A FLEXIBLE, COLLAPSIBLE, HEMO-REPELLANT BLOOD CONTAINER AT THE OTHER END, A LENGTH OF RESILIENT TUBING CONNECTING SAID CONTAINER TO A SECOND FLEXIBLE, COLLAPSIBLE CONTAINER TO FORM A UNITARY SYSTEM, A REMOVABLE, TRANSVERSE MEMBRANE POSITIVELY CLOSING SAID CONNECTING TUBING TO THE FLOW OF FLUID BETWEEN SAID CONTAINERS AND A FREE MOVING MEMBRANE-REMOVING, HOLLOW CANNULA LOCATED WHOLLY WITHIN SAID TUBING, THE CANNULA BEING COMPLETELY UNATTACHED TO SAID TUBING AND ANY PART OF SAID SYSTEM, SAID CANNULA BEING PROPORTIONED TO READILY FIT IN AND MOVE WITHIN SAID TUBING SO THAT THE CANNULA CAN BE EXTERNALLY MANIPULATED TO REMOVE SAID MEMBRANE WITHOUT OPENING SAID TUBING, SAID CANNULA BEING FURTHER MANIPULATABLE SUBSTANTIALLY OUT OF SAID TUBING INTO ONE OF SAID CONTAINERS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63923A US3110308A (en) | 1960-10-20 | 1960-10-20 | Parenteral fluid administration equiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63923A US3110308A (en) | 1960-10-20 | 1960-10-20 | Parenteral fluid administration equiment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3110308A true US3110308A (en) | 1963-11-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US63923A Expired - Lifetime US3110308A (en) | 1960-10-20 | 1960-10-20 | Parenteral fluid administration equiment |
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| US (1) | US3110308A (en) |
Cited By (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3276589A (en) * | 1961-12-18 | 1966-10-04 | Jankay Lester | Apparatus for maintenance and treatment of blood in vitro |
| US3648693A (en) * | 1969-05-28 | 1972-03-14 | Jintan Terumo Co | Bag apparatus for transfusion of blood or fluid involving heat shrinkable tube means |
| US3677248A (en) * | 1970-08-27 | 1972-07-18 | American Hospital Supply Corp | Surgical irrigation apparatus and method of using same |
| US3788374A (en) * | 1972-01-26 | 1974-01-29 | Jintan Terumo Co | Parenteral solution bag |
| US3870042A (en) * | 1971-10-13 | 1975-03-11 | Lab Medicoplast | Apparatus for separating and injecting blood component |
| DE2439392A1 (en) * | 1973-10-23 | 1975-04-24 | Sorenson Research Co | DEVICE AND METHOD FOR ASEPTIC COLLECTION OF FLUIDS BY VACUUM PRESSURE |
| US3986506A (en) * | 1974-09-03 | 1976-10-19 | Baxter Travenol Laboratories, Inc. | Apparatus for separation of cryoprecipitate from blood plasma and method |
| US4007738A (en) * | 1974-07-31 | 1977-02-15 | Terumo Corporation | Mechanism for allowing blood bags to communicate with each other |
| US4056116A (en) * | 1976-09-08 | 1977-11-01 | Baxter Travenol Laboratories, Inc. | Valve for interconnecting sterile containers and the like |
| US4183434A (en) * | 1977-09-02 | 1980-01-15 | Pharmachem Corporation | Peelable seal |
| US4195632A (en) * | 1978-05-03 | 1980-04-01 | Cutter Laboratories, Inc. | Fluid flow valve |
| US4198972A (en) * | 1978-04-17 | 1980-04-22 | Pharmachem Corporation | Blood and blood component storage bags |
| FR2450752A1 (en) * | 1979-03-05 | 1980-10-03 | Baxter Travenol Lab | SEPARABLE SEALING CLOSURE FOR FLEXIBLE CONTAINER; BLOOD BAG COMPRISING SUCH A BODY AND METHOD FOR CLOSING A FLEXIBLE CONTAINER BY MEANS OF SUCH A BODY |
| FR2453652A1 (en) * | 1979-04-09 | 1980-11-07 | Baxter Travenol Lab | IMPROVEMENT IN FLAT-CONTAINABLE CONTAINERS FOR MEDICAL USE SOLUTIONS |
| US4232721A (en) * | 1979-04-09 | 1980-11-11 | Baxter Travenol Laboratories, Inc. | Collapsible solution container having rectangular shoulder |
| US4234026A (en) * | 1979-03-05 | 1980-11-18 | Baxter Travenol Laboratories, Inc. | Seal for flexible container |
| US4305443A (en) * | 1979-03-05 | 1981-12-15 | Baxter Travenol Laboratories, Inc. | Seal for flexible container having flexible, generally conical portions |
| US4320789A (en) * | 1979-04-09 | 1982-03-23 | Baxter Travenol Laboratories, Inc. | Collapsible solution container |
| WO1983001569A1 (en) * | 1981-11-09 | 1983-05-11 | Baxter Travenol Lab | Multiple chamber solution container including positive test for homogenous mixture |
| DE3238836A1 (en) * | 1982-03-12 | 1983-09-22 | Terumo K.K., Tokyo | MEDICAL DEVICE AND METHOD FOR THEIR PRODUCTION |
| DE3238834A1 (en) * | 1982-03-12 | 1983-09-22 | Terumo K.K., Tokyo | CANNULA UNIT AND MEDICAL BAG WITH IT |
| US4465488A (en) * | 1981-03-23 | 1984-08-14 | Baxter Travenol Laboratories, Inc. | Collapsible multi-chamber medical fluid container |
| US4915683A (en) * | 1986-11-21 | 1990-04-10 | The Medical College Of Wisconsin, Inc. | Antiviral method, agents and apparatus |
| US4994039A (en) * | 1985-11-15 | 1991-02-19 | Mattson Philip D | Apparatus and method for patients from a single donor or a restricted group of donors |
| US5039483A (en) * | 1987-03-10 | 1991-08-13 | The Medical College Of Wisconsin, Inc. | Antiprotozoan method |
| US5114004A (en) * | 1990-02-14 | 1992-05-19 | Material Engineering Technology Laboratory Inc. | Filled and sealed, self-contained mixing container |
| US5167656A (en) * | 1991-01-22 | 1992-12-01 | Baxter International Inc. | Blood container having lay-flat sample reservoir |
| US5304113A (en) * | 1986-11-21 | 1994-04-19 | The Mcw Research Foundation, Inc. | Method of eradicating infectious biological contaminants |
| US20030146170A1 (en) * | 2002-02-01 | 2003-08-07 | Frank Corbin | Whole blood collection and processing method |
| US6764482B2 (en) | 1996-05-03 | 2004-07-20 | Baxter International Inc. | Dual-filled twin bag, a package and a method for forming a package for administering a solution |
| US20040233779A1 (en) * | 2003-05-19 | 2004-11-25 | Jean-Pascal Zambaux | Flexible mixing bag for mixing solids, liquids and gases |
| DE102004015031A1 (en) * | 2004-03-27 | 2005-10-20 | Drk Blutspendedienst West Ggbm | Transitional closure for blood bag systems |
| JP2010188197A (en) * | 2010-06-09 | 2010-09-02 | Jms Co Ltd | Blood component dispenser |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1082035A (en) * | 1953-05-28 | 1954-12-24 | Apparatus for collecting, storing and distributing human blood | |
| US2702034A (en) * | 1950-07-20 | 1955-02-15 | Fenwal Inc | Apparatus for collecting, storing, and dispensing whole blood |
-
1960
- 1960-10-20 US US63923A patent/US3110308A/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2702034A (en) * | 1950-07-20 | 1955-02-15 | Fenwal Inc | Apparatus for collecting, storing, and dispensing whole blood |
| FR1082035A (en) * | 1953-05-28 | 1954-12-24 | Apparatus for collecting, storing and distributing human blood |
Cited By (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3276589A (en) * | 1961-12-18 | 1966-10-04 | Jankay Lester | Apparatus for maintenance and treatment of blood in vitro |
| US3648693A (en) * | 1969-05-28 | 1972-03-14 | Jintan Terumo Co | Bag apparatus for transfusion of blood or fluid involving heat shrinkable tube means |
| US3677248A (en) * | 1970-08-27 | 1972-07-18 | American Hospital Supply Corp | Surgical irrigation apparatus and method of using same |
| US3870042A (en) * | 1971-10-13 | 1975-03-11 | Lab Medicoplast | Apparatus for separating and injecting blood component |
| US3788374A (en) * | 1972-01-26 | 1974-01-29 | Jintan Terumo Co | Parenteral solution bag |
| DE2439392A1 (en) * | 1973-10-23 | 1975-04-24 | Sorenson Research Co | DEVICE AND METHOD FOR ASEPTIC COLLECTION OF FLUIDS BY VACUUM PRESSURE |
| US4007738A (en) * | 1974-07-31 | 1977-02-15 | Terumo Corporation | Mechanism for allowing blood bags to communicate with each other |
| US3986506A (en) * | 1974-09-03 | 1976-10-19 | Baxter Travenol Laboratories, Inc. | Apparatus for separation of cryoprecipitate from blood plasma and method |
| US4056116A (en) * | 1976-09-08 | 1977-11-01 | Baxter Travenol Laboratories, Inc. | Valve for interconnecting sterile containers and the like |
| US4183434A (en) * | 1977-09-02 | 1980-01-15 | Pharmachem Corporation | Peelable seal |
| US4198972A (en) * | 1978-04-17 | 1980-04-22 | Pharmachem Corporation | Blood and blood component storage bags |
| US4195632A (en) * | 1978-05-03 | 1980-04-01 | Cutter Laboratories, Inc. | Fluid flow valve |
| FR2450752A1 (en) * | 1979-03-05 | 1980-10-03 | Baxter Travenol Lab | SEPARABLE SEALING CLOSURE FOR FLEXIBLE CONTAINER; BLOOD BAG COMPRISING SUCH A BODY AND METHOD FOR CLOSING A FLEXIBLE CONTAINER BY MEANS OF SUCH A BODY |
| US4234026A (en) * | 1979-03-05 | 1980-11-18 | Baxter Travenol Laboratories, Inc. | Seal for flexible container |
| US4305443A (en) * | 1979-03-05 | 1981-12-15 | Baxter Travenol Laboratories, Inc. | Seal for flexible container having flexible, generally conical portions |
| FR2453652A1 (en) * | 1979-04-09 | 1980-11-07 | Baxter Travenol Lab | IMPROVEMENT IN FLAT-CONTAINABLE CONTAINERS FOR MEDICAL USE SOLUTIONS |
| US4232721A (en) * | 1979-04-09 | 1980-11-11 | Baxter Travenol Laboratories, Inc. | Collapsible solution container having rectangular shoulder |
| US4320789A (en) * | 1979-04-09 | 1982-03-23 | Baxter Travenol Laboratories, Inc. | Collapsible solution container |
| US4465488A (en) * | 1981-03-23 | 1984-08-14 | Baxter Travenol Laboratories, Inc. | Collapsible multi-chamber medical fluid container |
| WO1983001569A1 (en) * | 1981-11-09 | 1983-05-11 | Baxter Travenol Lab | Multiple chamber solution container including positive test for homogenous mixture |
| US4396383A (en) * | 1981-11-09 | 1983-08-02 | Baxter Travenol Laboratories, Inc. | Multiple chamber solution container including positive test for homogenous mixture |
| DE3238834A1 (en) * | 1982-03-12 | 1983-09-22 | Terumo K.K., Tokyo | CANNULA UNIT AND MEDICAL BAG WITH IT |
| DE3249823C2 (en) * | 1982-03-12 | 1988-06-01 | Terumo Kabushiki Kaisha Trading As Terumo Corp., Tokio/Tokyo, Jp | |
| DE3238836A1 (en) * | 1982-03-12 | 1983-09-22 | Terumo K.K., Tokyo | MEDICAL DEVICE AND METHOD FOR THEIR PRODUCTION |
| US4994039A (en) * | 1985-11-15 | 1991-02-19 | Mattson Philip D | Apparatus and method for patients from a single donor or a restricted group of donors |
| US5304113A (en) * | 1986-11-21 | 1994-04-19 | The Mcw Research Foundation, Inc. | Method of eradicating infectious biological contaminants |
| US4915683A (en) * | 1986-11-21 | 1990-04-10 | The Medical College Of Wisconsin, Inc. | Antiviral method, agents and apparatus |
| US5039483A (en) * | 1987-03-10 | 1991-08-13 | The Medical College Of Wisconsin, Inc. | Antiprotozoan method |
| US5114004A (en) * | 1990-02-14 | 1992-05-19 | Material Engineering Technology Laboratory Inc. | Filled and sealed, self-contained mixing container |
| US5167656A (en) * | 1991-01-22 | 1992-12-01 | Baxter International Inc. | Blood container having lay-flat sample reservoir |
| US6764482B2 (en) | 1996-05-03 | 2004-07-20 | Baxter International Inc. | Dual-filled twin bag, a package and a method for forming a package for administering a solution |
| US20030146170A1 (en) * | 2002-02-01 | 2003-08-07 | Frank Corbin | Whole blood collection and processing method |
| US20050274673A1 (en) * | 2002-02-01 | 2005-12-15 | Gambro, Inc | Whole blood collection and processing method |
| US6994790B2 (en) | 2002-02-01 | 2006-02-07 | Gambro, Inc. | Whole blood collection and processing method |
| US20040233779A1 (en) * | 2003-05-19 | 2004-11-25 | Jean-Pascal Zambaux | Flexible mixing bag for mixing solids, liquids and gases |
| US7083323B2 (en) * | 2003-05-19 | 2006-08-01 | Advanced Technology Materials, Inc. | Flexible mixing bag for mixing solids, liquids and gases |
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