Recherche Images Maps Play YouTube Actualités Gmail Drive Plus »
Connexion
Les utilisateurs de lecteurs d'écran peuvent cliquer sur ce lien pour activer le mode d'accessibilité. Celui-ci propose les mêmes fonctionnalités principales, mais il est optimisé pour votre lecteur d'écran.

Brevets

  1. Recherche avancée dans les brevets
Numéro de publicationUS3136440 A
Type de publicationOctroi
Date de publication9 juin 1964
Date de dépôt25 juin 1963
Date de priorité25 juin 1963
Autre référence de publicationDE1498600B1, DE1498600C2
Numéro de publicationUS 3136440 A, US 3136440A, US-A-3136440, US3136440 A, US3136440A
InventeursGeorge H Keller, Albert E Krug
Cessionnaire d'origineBecton Dickinson Co
Exporter la citationBiBTeX, EndNote, RefMan
Liens externes: USPTO, Cession USPTO, Espacenet
Self sealing pierceable stopper for sealed containers
US 3136440 A
Résumé  disponible en
Images(1)
Previous page
Next page
Revendications  disponible en
Description  (Le texte OCR peut contenir des erreurs.)

June 9, 1964 A. E. KRUG ETAL 3,136,440

SELF SEALING PIERCEABLE STOPPER FOR SEALED CONTAINERS Filed June 25, 1963 INVENTORS. 4155,?! 5. l/IPUG 660/4 6! M K5440? III'TOIP/VEYJ United States Patent 3,136,440 SELF SEALING PIERCEABLE STOPPER FOR SEALED CONTAINERS Albert E. Krug, Wyclkolf, and George H. Keller, Ridgewood, N.J., assignors to Becton Dickinson and Company, East Rutherford, NJL, a corporation of New Jersey Filed June 25, 1963, Ser. No. 290,899 1 @laim. (Cl. 215-47) This invention relates to an improved self sealing pierceable stopper for sealed containers.

In the medical, biological and laboratory fields, sealed containers are frequently provided with pierceable self sealing stoppers whereby entry can be made into the container by means of a hypodermic needle so that fluids can be inserted in and removed from the container without breaking the sterility of the container. After the needle is removed from the stopper it immediately reseals. One type of stopper used'for this purpose is made of elastomeric material and is provided with a cylindrical plug portion, an enlarged head portion and a pierceable diaphragm extending across the stopper. Stoppers of this type have frequently been used with evacuated tubes and containers used in the collection of blood. This type of stopper has served very satisfactorily to provide the desired seal and to permit the insertion and removal of fluids. However, from time to time, difficulty has been encountered with the stopper in that it automatically escaped or ejected from the container breaking the sterility and causing contamination or loss of the contents.

It is a prime object of the present invention to provide an improved pierceable self sealing stopper of the above type which may be readily inserted in and removed from the opening in a container but which when inserted in the opening will remain firmly seated in place without danger of accidental release orejection.

Further objects include the provision of an improved pierceable self sealing stopper of the above type which is of relatively simple and inexpensive construction; which may be readily applied to and removed from a container and used in the same manner as stoppers of this type heretofore available; and which serves to preserve the seal and sterility of the container to which it is applied while permitting the insertion and removal of fluids by means of a hypodermic needle.

Our invention contemplates the provision of a self sealing pierceable stopper having a body portion made of elastomeric material and having a plug portion for inserting in the opening in the container and an enlarged head portion for engaging the outer end of the container. Around the plug portion immediately adjacent the enlarged head portion we provide a circumferential groove so as to relieve the stresses resulting from the resistance of the head portion to the compression of the plug. In accordance with a further aspect of our invention, recesses are provided at the opposite end of the stopper and the upper surface of the diaphragm is concave and the lower surface is convex thus directing the flow of the diaphragm material inwardly when the plug is compressed in insertion in the opening of a container.

In the accompanying drawing:

FIG. 1 is a side elevational view partially in section of a blood collecting assembly having a stopper embodying our invention applied to an evacuated tube or container;

FIG. 2 is an enlarged detailed view in section of the upper end of the container with the stopper applied thereto;

FIG. 3 is an exploded view in perspective of the stopper and the upper portion of the container; and

I by the fluids with which it is used. For this purpose we 3,136,440 Patented June 9, 1964 "ice FIG. 4 is a partially sectional side elevational view of the plug.

Our improved stopper is shown generally at 5. In FIGS. 1 and 2 it is illustrated as applied to the open upper end of a tubular container 6 which is closed at its lower end. The assembly illustrated is of the type frequently used in collecting blood specimens and the stopper has sealing engagement with the container and said container is at least partially evacuated so that blood will be drawn into the container when a cannula having connection with a bloodvessel is inserted therethrough.

Container 6 is preferably made of glass, but it may be made of a suitable plastic material inert to. and unaffected by the fluids to be collected therein. Assembled with the container and stopper in FIG. 1 is a holder 7 open at its lower end and of a size to have sliding fit with the container as shown. The holder 20 has a tapered top portion 8 formed with an aperture therethrough with which the hub-like fitting 9 has sealing engagement. A double ended cannula is mounted in sealing relationship with the hub-like fitting 9 with one end projecting into the holder and the other end projecting outwardly therefrom. In using the device illustrated in FIG. 1, the outwardly projecting portion of the cannula may be inserted into a blood vessel and then the inwardly projecting portion of the cannula is projected through the stopper with the result that blood is drawn into the sealed, evacuated container, 6. When the desired quantity .of blood has been drawn into the container, the cannula, in normal practice, is withdrawn from the stopper and then from the blood vessel. Upon withdrawal of the cannula from the stopper, it automatically reseals itself. It should be understood that the container maybe sterilized before its use in this fashion and that it may contain various blood treathave found that natural or synthetic rubber serves quite satisfactorily. Various elastomeric plastic compositions having the above indicated characteristics may also be employed under certain circumstances as, for instance,

the polymers and copolymers of vinylchloride or'vinyldienechloride.

The body portion of the stopper comprises a plug 10 having an enlarged head portion 12 integrally connected to the upper end thereof. The outside diameter of the plug 10 is slightly larger than the inside diameter of the opening in the container to which it is applied. Thus, when the plug is inserted into the open end of the container as shown in FIGS. 1 and 2, it is partially compressed. This helps to insure sealing engagement with the container as well as self sealing of the stopper when a cannula which has been inserted therethrough is withdrawn therefrom. The diameter of the head portion should be large enough to overlap the open upper end of the container as shown in FIGS. 1 and 2 so that it can be pressed into engagement therewith when the stopper is applied to the container. Recesses 14 and 16 are formed in the upper head end of the stopper and in the lower plug end of the stopper as shown. Extending across the stopper so as to overlap the area of connection between the head and plug portions is a diaphragm 18 also formed integrally with the remainder of the stopper. The diaphragm provides a partition or separation between the recesses 14 and 16 through which the cannula may be inserted when it is desired to add or remove fluid from the container. The upper surface of the diaphragm is preferably concave as shown at 20 and the lower surface is preferably convex as shown at 22. Thus, when the plug is compressed, the flow of the elastomeric material in the diaphragm is directed inwardly thereby minimizing stresses which might tend to eject or force the stopper outwardly from the container.

Around the outer surface of the plug, immediately adjacent the head 12, we provide a circumferential groove 24 which servesto minimize or relieve the stresses adjacent this portion of the plug resulting from the resistance of the head of the stopper to compression of the plug when it is inserted in the opening in the container. Thus, stresses in this area of the plug which tend to eject the stopper from the container are minimized or eliminated.

In order to facilitate the insertion of the plug end of the stopper into the opening of the container, we preferably taper the outer surface of the plug inwardly toward the free end thereof, as shown at 2 6. I

In using our improved stopper, it is applied to a container having an opening whose inside diameter is slightly less than the outside diameter of the plug portion. The plug is inserted in the opening as shown in FIGS. 1 and 2 with the head overlapping and pressed against the outer end of the container. Thus, the stopper provides a seal for the open end of the container; The container may be evacuated by inserting a hypodermic needle through the diaphragm 18 and drawing a vacuum therethrough or by inserting the stopper in the containers while in anevacuated chamber. When the needle is then withdrawn, the diaphragm is then self sealing. If the container is to be used for the collection of blood, blood drawing and preserving materials may be inserted therein. The sealed container may be sterilized in an autoclave in the usual manner. Liquids may be introduced into and withdrawn from the container by means of a hypodermic needle inserted through the diaphragm. In the collection of blood samples, the assembled container and stopper may be used with a holder of the type shovm at 7 in the manner described at the beginning of this specification.

When the stopper is assembled with the container in the manner illustrated and described, the plug 1G is partially compressed and the frictional engagement between the plug and container serves to hold the stopper in place against accidental displacement. Stresses and forces which might tend to eject the stopper from the container are relieved and minimized due to the provision of the circumferential groove 24 immediately adjacent the head and due to the concave-convex configuration of the diaphragm which directs the flow of elastomeric material inwardly when the plug is compressed; It will be seen .Cil

, 4 7, that the stopper is designed so that the maximum amount of rubber is disposed down inside the tube or container to firmly seal it in place.

Thus, we have provided an improved self sealing pierceable stopper for sealed containers which may be readily applied to containers but which will be firmly retained in place while the stopper is in use. It will also be seen that the stopper is of relatively simple and inexpensive construction and that it can be readily utilized'in the manner of self sealing pierceable stoppers heretofore available so as to provide sealing engagement with the container and at the same time permitting the insertion and removal of materials into and from the container without breaking the seal.

Modifications may be made in the illustrated and described embodiment of our invention without departing from the invention as set forth in the accompanying claim.

We claim:

A self sealing pierceable stopper for sealing containers of'the type having a tubular top with an opening therethrough which comprises: a body made of elastomeric material and comprising a cylindrical plug and an enlarged flange like head at the upper end thereof, said head and plug having recesses entering from the ends thereof with a diaphragm at the intermediate portion integral with said body and separating said recesses and connected across the upper portion of the plug and the lower portion of the head, said diaphragm having a concave'upper surface at the head end of the body with its central portion extending inwardly to a point adjacent the plane of the juncture between, the plug and head and'a convex lower surface at the plug end. and spaced from the plane of the juncture between the head and plug and the cylindrical plug having an outside diameter greater than the inside diameter of the opening in the container in which it is inserted so that the plug and diaphragm are partially compressed when inserted therein, asid plug having a circumferential groove extending completely around its outer surface immediately adjacent the head so as to relieve stresses of the plug resulting from resistance of said head-portion to compression of the plug and with the major portion of the diaphragm being positioned Within the plug so that when the plug is circumferentially compressed the elastomeric material in the diaphragm will flow inwardly in the direction of its convex surface.

References Cited in the file of this patent UNITED STATES PATENTS 2,836,320 Carroll May 27, 1958 2,923,427 Klopfenstein a Feb. 2, 1960 F REIGNPATENTS 552,472 Italy Dec. 3, 1956

Citations de brevets
Brevet cité Date de dépôt Date de publication Déposant Titre
US2836320 *13 sept. 195627 mai 1958Sterling Drug IncSterile ampule package
US2923427 *4 mai 19562 févr. 1960Klopfenstein Florenc StoianoffClosure for hypodermic solution containers
IT552472B * Titre non disponible
Référencé par
Brevet citant Date de dépôt Date de publication Déposant Titre
US3653528 *3 mars 19704 avr. 1972West CoStopper for medicament flasks
US3849072 *25 avr. 197219 nov. 1974Becton Dickinson CoPlasma separator
US3941128 *18 oct. 19742 mars 1976Affiliated Hospital Products, Inc.Fluid dispensing arrangement
US3958572 *16 déc. 197425 mai 1976Corning Glass WorksBlood collecting and separating assembly stopper
US4111326 *5 oct. 19765 sept. 1978Becton, Dickinson And CompanyClosure for air evacuated container
US4136794 *23 févr. 197830 janv. 1979Becton, Dickinson And CompanyCannula pierceable, self-sealing closure
US4181233 *15 nov. 19781 janv. 1980Becton, Dickinson And CompanyOne-way valve stopper
US4186840 *13 sept. 19785 févr. 1980Becton, Dickinson And CompanyCannulapierceable, self-sealing closure
US4187952 *13 sept. 197812 févr. 1980Becton, Dickinson And CompanyCannula pierceable, self-sealing closure
US4226333 *13 sept. 19787 oct. 1980Becton, Dickinson And CompanyCannula pierceable self-sealing closure
US4236647 *15 janv. 19792 déc. 1980Kotturan Paulson AContainer for sterile liquids
US4254884 *15 oct. 197910 mars 1981Toppan Printing Co., Ltd.Plug body for a container
US4290534 *8 mai 198022 sept. 1981Becton, Dickinson And CompanyCannula pierceable self-sealing closure
US4295572 *8 mai 198020 oct. 1981Becton, Dickinson And CompanyCannula pierceable self-sealing closure
US4301936 *8 mai 198024 nov. 1981Becton, Dickinson And CompanyCannula pierceable self-sealing closure
US4385637 *29 déc. 198031 mai 1983American Hospital Supply CorporationBlood sampler
US4444330 *27 juil. 198224 avr. 1984Terumo Kabushiki KaishaMedical container stopper
US4664275 *5 sept. 198512 mai 1987Terumo Kabushiki KaishaCrosslinked butyl rubber, thermoplastic resin, inorganic powder
US4671331 *13 mars 19869 juin 1987Lyphomed, Inc.Cover for medicinal vial
US4682703 *24 avr. 198628 juil. 1987Terumo Kabushiki KaishaStopper for medical container
US4735832 *24 févr. 19875 avr. 1988Terumo Kabushiki KaishaGas barrier silicon-coatings
US4741446 *29 déc. 19863 mai 1988Becton, Dickinson And CompanyComputer generated stopper
US4893636 *9 mars 198816 janv. 1990Sherwood Medical CompanyMedical container stopper
US4991104 *19 mars 19905 févr. 1991Becton, Dickinson And CompanyComputer generated stopper
US5060659 *11 août 198929 oct. 1991Sherwood Medical CompanyMedical container stopper
US5088995 *22 juin 199018 févr. 1992Baxter International Inc.Port and closure assembly including a resealing injection site for a container
US5257529 *8 mars 19932 nov. 1993Nissho CorporationMethod and device for measurement of viscosity of liquids
US66723452 oct. 20026 janv. 2004Sarstedt AgApparatus for forming a vacuum in a blood tube
US6898991 *29 oct. 200231 mai 2005Bruker Daltonik GmbhSampler for dust on surfaces
US692904019 juin 200316 août 2005Medical Instill Technologies, Inc.Sterile filling machine having needle filling station within e-beam chamber
US6976509 *2 août 200420 déc. 2005Kirvan Clifford JMethod and apparatus for pressurizing plastic pipe
US699721912 mai 200414 févr. 2006Medical Instill Technologies, Inc.Dispenser and apparatus and method for filling a dispenser
US700080612 juil. 200421 févr. 2006Medical Instill Technologies, Inc.Fluid dispenser having a housing and flexible inner bladder
US703263128 janv. 200425 avr. 2006Medical Instill Technologies, Inc.Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
US707717628 avr. 200418 juil. 2006Medical Instill Technologies, Inc.Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US7081103 *4 nov. 200225 juil. 2006Baxter International Inc.Direct dual filling device for sealing agents
US71006463 sept. 20035 sept. 2006Medical Instill Technologies, Inc.Sealed containers and methods of making and filling same
US711164911 avr. 200526 sept. 2006Medical Instill Technologies, Inc.Sterile filling machine having needle filling station within e-beam chamber
US71862413 oct. 20026 mars 2007Medical Instill Technologies, Inc.Syringe with needle penetrable and laser resealable stopper
US724368921 avr. 200617 juil. 2007Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion and related method
US726414226 janv. 20054 sept. 2007Medical Instill Technologies, Inc.Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
US72905731 août 20056 nov. 2007Medical Instill Technologies, Inc.Dispenser with sealed chamber, one-way valve and needle penetrable and laser resealable stopper
US7318913 *29 oct. 200315 janv. 2008Cytologix CorporationInstrument that is capable of performing incubations of small volumes of reagents on the surface of a microscope slide
US73287298 févr. 200612 févr. 2008Medical Instill Technologies, Inc.Dispenser and apparatus and method for filling a dispenser
US744503316 juil. 20074 nov. 2008Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion and related method
US74906393 déc. 200717 févr. 2009Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion and related method
US750049831 oct. 200710 mars 2009Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion and related method
US755606625 sept. 20067 juil. 2009Medical Instill Technologies, Inc.Sterile filling machine having needle filling station and conveyor
US756850917 juil. 20064 août 2009Medical Instill Technologies, Inc.Container with valve assembly, and apparatus and method for filling
US764484231 août 200712 janv. 2010Medical Instill Technologies, Inc.Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
US77263521 sept. 20061 juin 2010Medical Instill Technologies, Inc.Sealed containers and methods of making and filling same
US772635731 oct. 20071 juin 2010Medical Instill Technologies, Inc.Resealable containers and assemblies for filling and resealing same
US77796095 mars 200724 août 2010Medical Instill Technologies, Inc.Method of filling a device
US77981855 nov. 200721 sept. 2010Medical Instill Technologies, Inc.Dispenser and method for storing and dispensing sterile food product
US781052913 févr. 200912 oct. 2010Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion
US782878724 févr. 20039 nov. 2010Fresenius Kabi Deutschland GmbhConnector for packaging containing medical fluids and packaging for medical fluids
US78617504 févr. 20084 janv. 2011Medical Instill Technologies, Inc.Dispenser and apparatus and method of filling a dispenser
US788693711 janv. 201015 févr. 2011Medical Instill Technologies, Inc.Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US79052572 juil. 200915 mars 2011Daniel PySterile filling machine having needle filling station and conveyor
US7934614 *7 juin 20063 mai 2011J. G. Finneran Associates, Inc.Two-piece seal vial assembly
US796703410 mars 200928 juin 2011Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion and related method
US79802763 sept. 201019 juil. 2011Medical Instill Technologies, Inc.Device with needle penetrable and laser resealable portion and related method
US79925971 juin 20109 août 2011Medical Instill Technologies, Inc.Sealed containers and methods of filling and resealing same
US811880218 août 201021 févr. 2012Fresenius Kabi Deutschland GmbhConnector for packaging containing medical fluids and packaging for medical fluids
US817306828 août 20078 mai 2012Dako Denmark A/SFluid exchange in a chamber on a microscope slide
US821108112 août 20053 juil. 2012Fresenius Kabi Deutschland GmbhClosing cap for containers filled with medical liquids
US82205072 sept. 201017 juil. 2012Medical Instill Technologies, Inc.Dispenser and method for storing and dispensing sterile product
US824052110 févr. 200614 août 2012Medical Instill Technologies, Inc.Fluid dispenser having a one-way valve, pump, variable-volume storage chamber, and a needle penetrable and laser resealable portion
US82724113 août 200925 sept. 2012Medical Instill Technologies, Inc.Lyophilization method and device
US834792328 juin 20118 janv. 2013Medical Instill Technologies, Inc.Device with penetrable and resealable portion and related method
US841385415 févr. 20119 avr. 2013Medical Instill Technologies, Inc.Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US844867411 mars 201128 mai 2013Medical Instill Technologies, Inc.Sterile filling machine having filling station and E-beam chamber
US8460620 *14 nov. 201111 juin 2013Becton, Dickinson And CompanySpecimen collection container assembly
US86278614 janv. 201114 janv. 2014Medical Instill Technologies, Inc.Dispenser and apparatus and method for filling a dispenser
US863183814 déc. 201121 janv. 2014Medical Instill Technologies, Inc.Device with penetrable and resealable portion and related method
US86721959 nov. 200718 mars 2014Medical Instill Technologies, Inc.Device with chamber and first and second valves in communication therewith, and related method
US875743615 févr. 200824 juin 2014Medical Instill Technologies, Inc.Method for dispensing ophthalmic fluid
US88069205 mars 200919 août 2014Becton, Dickinson And CompanyCo-molded pierceable stopper and method for making the same
US20090048534 *2 mai 200619 févr. 2009Daniele TrivaDevice for the Withdrawal, collection and Transport of Biological Specimens
US20120141341 *14 nov. 20117 juin 2012Becton, Dickinson And CompanySpecimen Collection Container Assembly
EP0174032A2 *6 sept. 198512 mars 1986TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATIONMedical container stopper
EP1064879A1 *10 mars 19993 janv. 2001Sekisui Chemical Co., Ltd.Plug body for vacuum specimen sampling container, vacuum specimen sampling container, vacuum specimen sampling system, vacuum specimen sampling holder, and thermoplastic elastomer composition for plug body
EP1182143A2 *23 août 200127 févr. 2002Daikyo Seiko, Ltd.Closure for vial
WO2013019157A1 *20 juil. 20127 févr. 2013Wikner JohanStopper sample container and method of measurement using said stopper
Classifications
Classification aux États-Unis215/247, 422/916, 600/577
Classification internationaleB65D51/00, B01L3/14, A61B5/15
Classification coopérativeA61B5/150732, A61B5/150496, A61B5/1405, A61B5/150389, A61B5/15003, B65D51/002, A61B5/150351, A61B5/154, B01L3/50825, A61B5/1438
Classification européenneB01L3/50825, A61B5/15B20, A61B5/154, A61B5/15B12, A61B5/15B18B2, A61B5/15B18B8F, A61B5/15B2D, B65D51/00B, A61B5/14B, A61B5/14B12