US3340873A - Compartmented medical container having a rupturable diaphragm between compartments - Google Patents

Compartmented medical container having a rupturable diaphragm between compartments Download PDF

Info

Publication number
US3340873A
US3340873A US54991366A US3340873A US 3340873 A US3340873 A US 3340873A US 54991366 A US54991366 A US 54991366A US 3340873 A US3340873 A US 3340873A
Authority
US
United States
Prior art keywords
diaphragm
plunger
compartmented
barrel
compartments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Solowey Ida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US54991366 priority Critical patent/US3340873A/en
Priority to FR110931A priority patent/FR1550103A/en
Application granted granted Critical
Publication of US3340873A publication Critical patent/US3340873A/en
Priority to BE706004D priority patent/BE706004A/xx
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093Containers having several compartments for products to be mixed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/19Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02Internal fittings
    • B65D25/04Partitions
    • B65D25/08Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents
    • B65D25/082Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents the partition being in the form of a plug or the like which is removed by increasing or decreasing the pressure within the container
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2027Separating means having frangible parts
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00Bottles and jars
    • Y10S215/08Mixing

Definitions

  • My invention is directed toward a hypodermic syringe which can contain two or more medicinal ingredients which are mixed only 'at the time of injection and in addition relates to bottles or vials containing two or more medicinal ingredients which are held isolated from each other until mixing is desired.
  • Another object is to provide a new and improved medicinal vial of the character indicated.
  • Still another object is to provide a new and improved medicinal bottle of the character indicated.
  • FIGURE 1 is a perspective view of my syringe
  • FIGURE 2 is a cross sectional view of a modification thereof
  • FIGURE 3 is a detail view of a portion of the syringe after an injection has been given;
  • FIGURE 4 is a cross sectional view of another modification
  • FIGURE 5 is a cross sectional view of my bottle
  • FIGURES 6 and 7 are partial sectional views of a further modification.
  • FIGURE 1 there is shown a hypodermic syringe having a barrel 10 with an open end 12 which accommodates a plunger 14.
  • Barrel 10 has a tip 16 at the other end arranged for hypodermic needle attachment.
  • Tip 16 has the conventional small orifice through which the medicine ejected from the barrel flows into the needle, and when not in use the tip is sealed by cap 18.
  • the portion of the barrel adjacent tip 16 is filled with a first medicinal ingredient either in powder form (to which liquid is added) or in liquid form.
  • a hollow rubber cylinder 20 having a diaphragm of very thin rubber 22 is then press fitted snugly into the barrel until the diaphragm just touches the top of the liquid level of the first ingredient.
  • the portion of the barrel adjacent the other side of the diaphragm and extending toward the open end is then filled with a second ingredient.
  • the plunger is inserted to rest on top of the second or top layer ingredient.
  • the head 26 of the plunger (which is contoured to conform to the inside of cylinder 20) moves downward into the second ingredient, and the pressure causes a ruptured diaphragm 22 and permits the two ingredients to mix. Thereafter, the head 26 and shoulder engages the cylinder and the head and the cylinder move downward together toward the tip ejecting the mixture thru the syringe.
  • a stop 14a can be provided at the open end 12, as seen in FIG- URE 2.
  • FIGURE 4 shows a vial having an upper chamber 30 containing one ingredient, a lower chamber 32 having a second ingredient, a hollow section 34 open at both ends interconnecting these chambers.
  • a rubber cylinder 20 having a diaphragm 22 is fitted in section 34.
  • a conventional syringe can then be filled in conventional manner by inserting the hypodermic needle through plunger 36 into the chamber.
  • a sharp ridge 23 is provided under diaphragm 22 to help puncture the diaphragm.
  • FIGURE 5 shows an arrangement similar to FIG- URE 4, except that the top of chamber 30 carries a screwon cover 40 having a hole 42 through which a portion of a plunger 44 extends. In this case, the plunger cannot go through the cover and the plunger is reciprocated through the cover 40 to generate pressure on the diaphragm.
  • the diaphragm 22 of the above said devices can be fabricated from any suitable thin flexible material.
  • a diaphragm 40 is used which is cup shaped but includes a relatively thin flexible band 41 which is normally spaced from barrel 10.
  • the band 41 expands radially into sealing engagement with barrel 10 because of the increase in pressure.
  • the diaphragm cup will cling more firmly to the barrel and the fluid pressure will build up more rapidly to cause a more efiective rupturing of the diaphragm.
  • a medical mixing container having upper and lower chambers sealingly separated by a thin rupturable diaphragm transversely mounted sealingly and longitudinally movable within the container, said diaphragm being in the form of an expandable cylinder having a circumferential barrel and a transverse bottom, said barrel having a portion normally spaced from the container and having an upper shoulder, in combination with a plunger longitudinally movable within one of said chambers and being contoured to fit snugly within the said chambers, including ingredients which are mixed when the diaphragm is ruptured, said plunger having surfaces adapted to sealingly engage the barrel, bottom and shoulder of the diaphragm, whereby axial movement of the plunger will first cause the barrel to expand towards the container, whereby complete engagement with the wall being then eifected when the plunger has entered the cylinder to contact the barrel and snap the said portion against the container, whereby the diaphragm bottom is ruptured during the axial movement of the plunger, further movement of the plunger causing the plunger surfaces to

Description

.Sept. 12. 1967 SOLQWEY COMPARTMENTED MEDICAL CONTAINER HAVING A RUP'IURABLE DIAPHRAGM BETWEEN COMPARTMENTS Filed May 13 1966 E i 0mm;
)24 azowgy United States Patent 3,340,873 COMPARTMENTED MEDICAL CONTAINER HAV- ING A RUPTURABLE DIAPHRAGM BETWEEN COMPARTMENTS Ida Solowey, P.0. Box 34, Fresh Meadows Station,
Flushing, N.Y. 11365 Filed May 13, 1966, Ser. No. 549,913 1 Claim. (Cl. 128-272) My invention is directed toward a hypodermic syringe which can contain two or more medicinal ingredients which are mixed only 'at the time of injection and in addition relates to bottles or vials containing two or more medicinal ingredients which are held isolated from each other until mixing is desired.
It is an object of my invention to provide a new and improved syringe of the character indicated.
Another object is to provide a new and improved medicinal vial of the character indicated.
Still another object is to provide a new and improved medicinal bottle of the character indicated.
All of the foregoing and still further objects and advantages of my invention will now be explained with reference both to this specification and to the drawings wherein:
FIGURE 1 is a perspective view of my syringe;
FIGURE 2 is a cross sectional view of a modification thereof;
FIGURE 3 is a detail view of a portion of the syringe after an injection has been given;
FIGURE 4 is a cross sectional view of another modification;
FIGURE 5 is a cross sectional view of my bottle;
FIGURES 6 and 7 are partial sectional views of a further modification.
Referring now to FIGURE 1, there is shown a hypodermic syringe having a barrel 10 with an open end 12 which accommodates a plunger 14. Barrel 10 has a tip 16 at the other end arranged for hypodermic needle attachment. Tip 16 has the conventional small orifice through which the medicine ejected from the barrel flows into the needle, and when not in use the tip is sealed by cap 18.
In use, the portion of the barrel adjacent tip 16 is filled with a first medicinal ingredient either in powder form (to which liquid is added) or in liquid form. A hollow rubber cylinder 20 having a diaphragm of very thin rubber 22 is then press fitted snugly into the barrel until the diaphragm just touches the top of the liquid level of the first ingredient. The portion of the barrel adjacent the other side of the diaphragm and extending toward the open end is then filled with a second ingredient. The plunger is inserted to rest on top of the second or top layer ingredient. As the operator presses the plunger arm 24, the head 26 of the plunger (which is contoured to conform to the inside of cylinder 20) moves downward into the second ingredient, and the pressure causes a ruptured diaphragm 22 and permits the two ingredients to mix. Thereafter, the head 26 and shoulder engages the cylinder and the head and the cylinder move downward together toward the tip ejecting the mixture thru the syringe.
To prevent the plunger 14 from slipping out, a stop 14a can be provided at the open end 12, as seen in FIG- URE 2.
FIGURE 4 shows a vial having an upper chamber 30 containing one ingredient, a lower chamber 32 having a second ingredient, a hollow section 34 open at both ends interconnecting these chambers. A rubber cylinder 20 having a diaphragm 22 is fitted in section 34. When a rubber plunger 36 in the top of the chamber 30 is depressed, the diaphragm is ruptured and the ingredients are mixed. A conventional syringe can then be filled in conventional manner by inserting the hypodermic needle through plunger 36 into the chamber. A sharp ridge 23 is provided under diaphragm 22 to help puncture the diaphragm.
FIGURE 5 shows an arrangement similar to FIG- URE 4, except that the top of chamber 30 carries a screwon cover 40 having a hole 42 through which a portion of a plunger 44 extends. In this case, the plunger cannot go through the cover and the plunger is reciprocated through the cover 40 to generate pressure on the diaphragm. The diaphragm 22 of the above said devices can be fabricated from any suitable thin flexible material.
In FIGURES 6 and 7 a diaphragm 40 is used which is cup shaped but includes a relatively thin flexible band 41 which is normally spaced from barrel 10. When the plunger 14 is depressed towards the diaphragm the band 41 expands radially into sealing engagement with barrel 10 because of the increase in pressure. Thus the diaphragm cup will cling more firmly to the barrel and the fluid pressure will build up more rapidly to cause a more efiective rupturing of the diaphragm.
It is to be noted that the engagement between the plunger and diaphragm and their combined further movement causes a simultaneous ejecting pressure and further mixing of the ingredients.
Having thus described my invention, I claim as new and desire to secure by Letters Patent:
A medical mixing container having upper and lower chambers sealingly separated by a thin rupturable diaphragm transversely mounted sealingly and longitudinally movable within the container, said diaphragm being in the form of an expandable cylinder having a circumferential barrel and a transverse bottom, said barrel having a portion normally spaced from the container and having an upper shoulder, in combination with a plunger longitudinally movable within one of said chambers and being contoured to fit snugly within the said chambers, including ingredients which are mixed when the diaphragm is ruptured, said plunger having surfaces adapted to sealingly engage the barrel, bottom and shoulder of the diaphragm, whereby axial movement of the plunger will first cause the barrel to expand towards the container, whereby complete engagement with the wall being then eifected when the plunger has entered the cylinder to contact the barrel and snap the said portion against the container, whereby the diaphragm bottom is ruptured during the axial movement of the plunger, further movement of the plunger causing the plunger surfaces to sealingly engage the diaphragm thereby moving the diaphragm axially, including means mounted on the end of the container opposite the plunger adapted to receive a hypodermic needle and wherein the plunger extends through an open end of the container having a perforated closure wherein said closure functions as a stop to prevent complete removal of the plunger from the container.
References Cited UNITED STATES PATENTS 1,943,120 1/ 1934 Kabnick 128-218 2,590,900 4/ 1952 Sommerstein 128272 2,591,706 4/1952 Lockhart 128-218 2,705,956 4/ 1955 McLaughlin 128-272 FOREIGN PATENTS 961,289 4/ 1957 Germany.
RICHARD A. GAUDET, Primary Examiner.
DALTON L. TRULUCK, Examiner.
US54991366 1966-05-13 1966-05-13 Compartmented medical container having a rupturable diaphragm between compartments Expired - Lifetime US3340873A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US54991366 US3340873A (en) 1966-05-13 1966-05-13 Compartmented medical container having a rupturable diaphragm between compartments
FR110931A FR1550103A (en) 1966-05-13 1967-06-19 Two or more compartment hypodermic syringe.
BE706004D BE706004A (en) 1966-05-13 1967-11-03

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54991366 US3340873A (en) 1966-05-13 1966-05-13 Compartmented medical container having a rupturable diaphragm between compartments

Publications (1)

Publication Number Publication Date
US3340873A true US3340873A (en) 1967-09-12

Family

ID=24194888

Family Applications (1)

Application Number Title Priority Date Filing Date
US54991366 Expired - Lifetime US3340873A (en) 1966-05-13 1966-05-13 Compartmented medical container having a rupturable diaphragm between compartments

Country Status (3)

Country Link
US (1) US3340873A (en)
BE (1) BE706004A (en)
FR (1) FR1550103A (en)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870147A (en) * 1972-04-28 1975-03-11 Wolf Geraete Gmbh Container for storage and preparation of a plant protective material containing at least two components
US4159570A (en) * 1977-10-31 1979-07-03 Dentipressions Incorporated Disposable mixing syringe
US4191254A (en) * 1978-01-16 1980-03-04 Baughman Kenneth E Apparatus and method for plugging voids in a ground stratum
US4693706A (en) * 1986-08-11 1987-09-15 Mark L. Anderson Two compartment mixing syringe
US4983164A (en) * 1987-04-14 1991-01-08 Astra Meditec Ab Automatic two-chamber injector
US5002206A (en) * 1989-10-25 1991-03-26 Merck & Co., Inc. Double tip drug dispensing and metering device
US5137528A (en) * 1990-11-26 1992-08-11 Crose Virginia W Ampoule for administering a liquid local anaesthetic
US5196001A (en) * 1991-03-05 1993-03-23 Ti Kao Devices and methods for preparing pharmaceutical solutions
US5217433A (en) * 1991-05-24 1993-06-08 Merck & Co., Inc. Medication container for mixing two components
US5322800A (en) * 1991-06-26 1994-06-21 The United States Of America As Represented By The Secretary Of The Interior Method and device for safely preserving aqueous field samples using acid or base
US6372270B1 (en) * 1999-05-26 2002-04-16 Sean P. Denny Drink mix apparatus for making personal quantities of beverage
US6419414B1 (en) 2001-04-20 2002-07-16 3M Innovative Properties Company Container for multiple-component compositions
WO2003022696A1 (en) * 2001-09-10 2003-03-20 Den-Mat Corporation Unit-dose packaging system
US6543612B2 (en) 2001-05-21 2003-04-08 3M Innovative Properties Company Container for compositions made of two or more components
US6544213B1 (en) 1999-09-13 2003-04-08 Merck & Co., Inc. Dual compartment mixing and dispensing device
US20050113768A1 (en) * 2003-11-24 2005-05-26 Carlos Patrickson Pain-alleviating injection needle
WO2006118697A3 (en) * 2005-04-29 2007-01-25 Ipifini Programmable liquid containers
US20100240004A1 (en) * 2009-03-23 2010-09-23 Moshe Zalsman Capsule for mixing together two flowable materials, and kits including such capsules, particularly useful in dentistry
WO2011071463A1 (en) * 2009-12-07 2011-06-16 Merenkov Aleksandr Vladimirovich Container, container for packaging and storing two components, and container manufacturing method
AU2010101255B4 (en) * 2010-11-15 2011-09-22 Lumsden, Andrew A prefilled syringe for administering buffered lignocaine
WO2014180902A1 (en) * 2013-05-07 2014-11-13 Auxin Surgery Sa Device for chemically assisted dissection
US10335548B1 (en) 2017-06-09 2019-07-02 Cinti Medical, Inc. Syringe assembly
US20210069062A1 (en) * 2018-01-05 2021-03-11 Pacifi Limited Method and apparatus
US11284867B2 (en) 2019-06-20 2022-03-29 Spectrum Solutions L.L.C. Sample collection system including a sample collection vessel, sealing cap, and reagent chamber and valve assembly in the sealing cap
US11364095B2 (en) * 2015-12-23 2022-06-21 Medmix Switzerland Ag Discharger
US11536632B2 (en) 2011-06-19 2022-12-27 DNA Genotek, Inc. Biological collection system
US11572581B2 (en) 2002-06-07 2023-02-07 DNA Genotek, Inc. Compositions and methods for obtaining nucleic acids from sputum
US11712692B2 (en) 2018-11-20 2023-08-01 Spectrum Solutions L.L.C. Sample collection system including sealing cap and valve

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1943120A (en) * 1930-05-21 1934-01-09 Kabnick Stuart Hypodermic syringe
US2590900A (en) * 1949-03-23 1952-04-01 Sommerstein Cwi Ampoule
US2591706A (en) * 1950-09-29 1952-04-08 Compule Corp Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations
US2705956A (en) * 1952-03-10 1955-04-12 Howard J Mclaughlin Means of administering procaine and like preparations
DE961289C (en) * 1952-10-05 1957-04-04 Dr Med Dent Wilhelm Eisenberg Two-chambered ampoule designed for separate storage and for mixing the components of an agent to be sprayed

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1943120A (en) * 1930-05-21 1934-01-09 Kabnick Stuart Hypodermic syringe
US2590900A (en) * 1949-03-23 1952-04-01 Sommerstein Cwi Ampoule
US2591706A (en) * 1950-09-29 1952-04-08 Compule Corp Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations
US2705956A (en) * 1952-03-10 1955-04-12 Howard J Mclaughlin Means of administering procaine and like preparations
DE961289C (en) * 1952-10-05 1957-04-04 Dr Med Dent Wilhelm Eisenberg Two-chambered ampoule designed for separate storage and for mixing the components of an agent to be sprayed

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870147A (en) * 1972-04-28 1975-03-11 Wolf Geraete Gmbh Container for storage and preparation of a plant protective material containing at least two components
US4159570A (en) * 1977-10-31 1979-07-03 Dentipressions Incorporated Disposable mixing syringe
US4191254A (en) * 1978-01-16 1980-03-04 Baughman Kenneth E Apparatus and method for plugging voids in a ground stratum
US4693706A (en) * 1986-08-11 1987-09-15 Mark L. Anderson Two compartment mixing syringe
US4983164A (en) * 1987-04-14 1991-01-08 Astra Meditec Ab Automatic two-chamber injector
US5002206A (en) * 1989-10-25 1991-03-26 Merck & Co., Inc. Double tip drug dispensing and metering device
US5137528A (en) * 1990-11-26 1992-08-11 Crose Virginia W Ampoule for administering a liquid local anaesthetic
US5196001A (en) * 1991-03-05 1993-03-23 Ti Kao Devices and methods for preparing pharmaceutical solutions
US5217433A (en) * 1991-05-24 1993-06-08 Merck & Co., Inc. Medication container for mixing two components
US5322800A (en) * 1991-06-26 1994-06-21 The United States Of America As Represented By The Secretary Of The Interior Method and device for safely preserving aqueous field samples using acid or base
US6372270B1 (en) * 1999-05-26 2002-04-16 Sean P. Denny Drink mix apparatus for making personal quantities of beverage
US20020090426A1 (en) * 1999-05-26 2002-07-11 Denny Sean P. Methods and apparatus for making personal quantities of beverage
US6544213B1 (en) 1999-09-13 2003-04-08 Merck & Co., Inc. Dual compartment mixing and dispensing device
US6419414B1 (en) 2001-04-20 2002-07-16 3M Innovative Properties Company Container for multiple-component compositions
US6543612B2 (en) 2001-05-21 2003-04-08 3M Innovative Properties Company Container for compositions made of two or more components
WO2003022696A1 (en) * 2001-09-10 2003-03-20 Den-Mat Corporation Unit-dose packaging system
US11572581B2 (en) 2002-06-07 2023-02-07 DNA Genotek, Inc. Compositions and methods for obtaining nucleic acids from sputum
US20050113768A1 (en) * 2003-11-24 2005-05-26 Carlos Patrickson Pain-alleviating injection needle
US20090206084A1 (en) * 2005-04-29 2009-08-20 Ipifini, Inc. Programmable liquid containers
WO2006118697A3 (en) * 2005-04-29 2007-01-25 Ipifini Programmable liquid containers
US20100240004A1 (en) * 2009-03-23 2010-09-23 Moshe Zalsman Capsule for mixing together two flowable materials, and kits including such capsules, particularly useful in dentistry
WO2011071463A1 (en) * 2009-12-07 2011-06-16 Merenkov Aleksandr Vladimirovich Container, container for packaging and storing two components, and container manufacturing method
AU2010101255B4 (en) * 2010-11-15 2011-09-22 Lumsden, Andrew A prefilled syringe for administering buffered lignocaine
US11536632B2 (en) 2011-06-19 2022-12-27 DNA Genotek, Inc. Biological collection system
US11592368B2 (en) 2011-06-19 2023-02-28 DNA Genotek, Inc. Method for collecting and preserving a biological sample
US11549870B2 (en) 2011-06-19 2023-01-10 DNA Genotek, Inc. Cell preserving solution
US10092312B2 (en) 2013-05-07 2018-10-09 Auxin Surgery Sa Device for chemically assisted dissection
US11116536B2 (en) 2013-05-07 2021-09-14 Auxin Surgery Sa Device for chemically assisted dissection
WO2014180902A1 (en) * 2013-05-07 2014-11-13 Auxin Surgery Sa Device for chemically assisted dissection
US11364095B2 (en) * 2015-12-23 2022-06-21 Medmix Switzerland Ag Discharger
US10335548B1 (en) 2017-06-09 2019-07-02 Cinti Medical, Inc. Syringe assembly
US20210069062A1 (en) * 2018-01-05 2021-03-11 Pacifi Limited Method and apparatus
US11712692B2 (en) 2018-11-20 2023-08-01 Spectrum Solutions L.L.C. Sample collection system including sealing cap and valve
US11284867B2 (en) 2019-06-20 2022-03-29 Spectrum Solutions L.L.C. Sample collection system including a sample collection vessel, sealing cap, and reagent chamber and valve assembly in the sealing cap
US11547392B2 (en) 2019-06-20 2023-01-10 Spectrum Solutions L.L.C. Method of collecting and preserving a biological sample
US11701094B2 (en) 2019-06-20 2023-07-18 Spectrum Solutions L.L.C. Sample collection system including valve and plug assemblies

Also Published As

Publication number Publication date
FR1550103A (en) 1968-12-20
BE706004A (en) 1968-03-18

Similar Documents

Publication Publication Date Title
US3340873A (en) Compartmented medical container having a rupturable diaphragm between compartments
US3330281A (en) Combination syringe and vial mixing container
US2591706A (en) Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations
US3330282A (en) Combination syringe and vial mixing container
US3557787A (en) Disposable syringe
FI91932B (en) Dual chamber mixing dosing device
US3685514A (en) Two compartment syringe
US3838689A (en) Disposable syringe with slit valve
US3678931A (en) Syringe
US3946732A (en) Two-chamber mixing syringe
US3397694A (en) Combination syringe package, syringe and chamber
US2939459A (en) Tandem syringe
US3494359A (en) Two compartment syringe with a single barrel
US3336924A (en) Two compartment syringe package
US4226236A (en) Prefilled, vented two-compartment syringe
US3376866A (en) Medicament injector with attached vial
US3810469A (en) Multiple compartment hypodermic devices
US3540444A (en) Plastic ampoule for use with hypodermic injector
DE3766649D1 (en) CAPSULE TO MIX AND DISPENSE.
US3527215A (en) Syringe construction having internal bladder
US2653610A (en) Dispensing closure
US3757779A (en) Filter syringe
US2665690A (en) Plural-compartment admixing container or vial
US3392726A (en) Combination syringe and vial container
GB1314234A (en) Mixing containers for interreacting substances for preparing ready-for-use dental preparations