US3343538A - Apparatus for feeding multiple dose jet injectors - Google Patents

Apparatus for feeding multiple dose jet injectors Download PDF

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US3343538A
US3343538A US29989563A US3343538A US 3343538 A US3343538 A US 3343538A US 29989563 A US29989563 A US 29989563A US 3343538 A US3343538 A US 3343538A
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vial
container
liquid
multiple dose
injector
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David C Morley
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Allen and Hanburys Ltd
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Allen and Hanburys Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2017—Piercing means having three or more piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Definitions

  • This invention relates to an apparatus for feeding multiple dose jet injectors from liquid contained in a series of containers.
  • hypodermic injections are customarily given by the use of a hypodermic syringe which is charged with the medicament by piercing a rubber cap of a vial and withdrawing a part of the contents.
  • the use of this method is time consuming since the syringe has to be recharged prior to each injection.
  • a more recent method of giving injections is by the use of needleless or jet injectors which are based upon the principle of forcing the medicament through a small orifice at high pressure and velocity adequate to penetrate the skin. Some of these injectors are single dose syringes, the medicament being contained in the barrel of the instrument or in an arnpoule.
  • jet injector suffers from the same disadvantage as the standard hypodermic syringe, i.e. it has to be recharged prior to each use.
  • An alternative jet injector is the multiple dose type, with which the present invention is concerned.
  • the multiple dose jet injector is useful for mass vaccinations since no time is wasted in charging and sterilising it between injections. Hitherto the multiple dose jet injector has been fed from a storage vessel containing a relatively large volume of medicament, for example 1 litre.
  • medicaments are not normally packed in such vessels and it is an object of the present invention to provide an apparatus for feeding a multiple does jet injector from a series of standard small containers, e.g. vaccine bottles, without introducing .air into the injector.
  • the present invention provides an apparatus for feeding a multidose jet injector with liquid which comprises first and second stoppered containers, a liquid feed tube leading from a position inside the first container near the stopper thereof to the injector, a communication tube extending through both containers and their stoppers, the opposite ends of the said communication tube terminating near the respective bases of the containers, an air inlet tube leading into the second container and terminating at a position near the stopper thereof, and a bacterial filter in the air inlet-tube.
  • each of the containers is partially filled with injection liquid and the first container is inverted and positioned at a higher level than the second container which is upright.
  • the liquid feed tube from the first container to the injector then terminates in the first container below the level of the liquid therein.
  • the communication tube between the two containers terminates in the first container above the level of the liquid and terminates in the second container below the level of the liquid near the base of the container.
  • the air inlet tube to the second container terminates in the second container above the level of the liquid.
  • the two stoppered containers are preferably vaccine vials which are mounted vertically above each other in a common holder.
  • the feed tube, the communication tube Patented Sept. 26, 1967 and the air inlet tube are preferably needle shaped tubes, separate or concentric, the ends of which are sharpened so that they can readily be pushed through the stoppers of the containers.
  • a preferred embodiment of the invention is illustrated in the accompanying drawing which shows a sectional view of the apparatus.
  • a first, inverted vaccine vial 1 containing the medicament to be injected is mounted on a holder 2 vertically above a second upright lower vaccine vial 3 containing the same medicament.
  • a needle or feed tube 4 having a sharpened end passes through a rubber cap 5 of the upper or inverted vial 1 and connects a multiple dose jet injector indicated by the arow I, with the medicament in the inverted vial.
  • a second needle or air inlet tube 6, also having a sharpened end, passes through a rubber cap 7 of the lower vial and connects the atmosphere to the air space in the lower vial.
  • a filter 8, which is impervious to bacteria is mounted on the distal end of the second needle 6.
  • a third or communication needle or tube 9 having sharpened ends passes through the rubber caps 5 and 7 of both vials 1 and 3 and is of such a length that its upper end terminates near the base of the upper inverted vial 1 (which base will of course be at the top of the apparatus) and its lower end terminates near the base of the lower, upright vial 3.
  • the assembly of needles Prior to using the apparatus, the assembly of needles is sterilized.
  • the first needle 4 is then attached to the jet injector I, and the first vaccine vial 1 is inverted and is placed in position, the injector I being primed from the liquid in this vial. This leaves a small air space above the liquid.
  • the second vial 3 is then placed in position below the inverted vial. Whenever the injector I is used, liquid is removed from the upper vial 1 and therefore liquid from the second lower vial 3 flows up the com munication needle '9 into first vial 1 to replace the withdrawn liquid.
  • the upright vial 3 When the upright vial 3 is emptied it may be replaced by a new vaccine vial and any air trapped in the communication needle 9 is displaced into the air space above the liquid in the upper inverted vial 1.
  • the air space is therefore very slightly increased in volume, but it is possible to change the lower vial 3 numerous times before the inverted vial 1 requires replacement and the apparatus needs to be reprimed.
  • An apparatus for feeding a multid-ose injector with liquid and preventing air from being introduced int-o the injector between injections which comprises a first stoppered container, a second stoppered container, said second container being substantially upright and said first container being substantially inverted, a holder disposed between the stoppers of said containers in contiguous relationship thereto, a liquid feed tube extending from a position inside said first container near the stopper thereof through said stopper and holder outwardly of said holder, said tube being adapted to be connected to said multidose injector, a communication tube extending from a position near the base of said first container to a position near the base of said second container through said stoppers and holder, an air inlet tube extending from within said second container just below the stopper thereof outward through said stopper and holder and a filter substantially impervious to bacteria connected to the outward end of said air inlet tube, whereby any air within the communication tube is displaced into the air space above the liquid in the inverted container and is not introduced into the 2,58

Description

D. C. MORLEY Sept. 26, 1967 APPARATUS FOR FEEDING MULTIPLE DOSE JET INJECTORS Fild Aug. 5, 1963 INVENTOR ATTORNEY 7 v United States Patent 3,343,538 APPARATUS FOR FEEDING MULTIPLE DOSE JET INJECTORS David C. Morley, St. Albans, England, assignor to Allen and Hanhurys Limited, London, England, a British company Filed Aug. 5, 1963, Ser. No. 299,895 Claims priority, application Great Britain, Aug. 3, 1962, 29,956/62 1 Claim. (Cl. 128-215) This invention relates to an apparatus for feeding multiple dose jet injectors from liquid contained in a series of containers.
Hypodermic injections are customarily given by the use of a hypodermic syringe which is charged with the medicament by piercing a rubber cap of a vial and withdrawing a part of the contents. The use of this method is time consuming since the syringe has to be recharged prior to each injection. A more recent method of giving injections is by the use of needleless or jet injectors which are based upon the principle of forcing the medicament through a small orifice at high pressure and velocity adequate to penetrate the skin. Some of these injectors are single dose syringes, the medicament being contained in the barrel of the instrument or in an arnpoule. This type of jet injector suffers from the same disadvantage as the standard hypodermic syringe, i.e. it has to be recharged prior to each use. An alternative jet injector is the multiple dose type, with which the present invention is concerned. The multiple dose jet injector is useful for mass vaccinations since no time is wasted in charging and sterilising it between injections. Hitherto the multiple dose jet injector has been fed from a storage vessel containing a relatively large volume of medicament, for example 1 litre. However, medicaments are not normally packed in such vessels and it is an object of the present invention to provide an apparatus for feeding a multiple does jet injector from a series of standard small containers, e.g. vaccine bottles, without introducing .air into the injector.
Accordingly, the present invention provides an apparatus for feeding a multidose jet injector with liquid which comprises first and second stoppered containers, a liquid feed tube leading from a position inside the first container near the stopper thereof to the injector, a communication tube extending through both containers and their stoppers, the opposite ends of the said communication tube terminating near the respective bases of the containers, an air inlet tube leading into the second container and terminating at a position near the stopper thereof, and a bacterial filter in the air inlet-tube. In use, each of the containers is partially filled with injection liquid and the first container is inverted and positioned at a higher level than the second container which is upright. The liquid feed tube from the first container to the injector then terminates in the first container below the level of the liquid therein. The communication tube between the two containers terminates in the first container above the level of the liquid and terminates in the second container below the level of the liquid near the base of the container. The air inlet tube to the second container, terminates in the second container above the level of the liquid.
The two stoppered containers are preferably vaccine vials which are mounted vertically above each other in a common holder. The feed tube, the communication tube Patented Sept. 26, 1967 and the air inlet tube are preferably needle shaped tubes, separate or concentric, the ends of which are sharpened so that they can readily be pushed through the stoppers of the containers.
A preferred embodiment of the invention is illustrated in the accompanying drawing which shows a sectional view of the apparatus. A first, inverted vaccine vial 1 containing the medicament to be injected is mounted on a holder 2 vertically above a second upright lower vaccine vial 3 containing the same medicament. A needle or feed tube 4 having a sharpened end passes through a rubber cap 5 of the upper or inverted vial 1 and connects a multiple dose jet injector indicated by the arow I, with the medicament in the inverted vial. A second needle or air inlet tube 6, also having a sharpened end, passes through a rubber cap 7 of the lower vial and connects the atmosphere to the air space in the lower vial. A filter 8, which is impervious to bacteria is mounted on the distal end of the second needle 6. A third or communication needle or tube 9 having sharpened ends passes through the rubber caps 5 and 7 of both vials 1 and 3 and is of such a length that its upper end terminates near the base of the upper inverted vial 1 (which base will of course be at the top of the apparatus) and its lower end terminates near the base of the lower, upright vial 3.
Prior to using the apparatus, the assembly of needles is sterilized. The first needle 4 is then attached to the jet injector I, and the first vaccine vial 1 is inverted and is placed in position, the injector I being primed from the liquid in this vial. This leaves a small air space above the liquid. The second vial 3 is then placed in position below the inverted vial. Whenever the injector I is used, liquid is removed from the upper vial 1 and therefore liquid from the second lower vial 3 flows up the com munication needle '9 into first vial 1 to replace the withdrawn liquid. When the upright vial 3 is emptied it may be replaced by a new vaccine vial and any air trapped in the communication needle 9 is displaced into the air space above the liquid in the upper inverted vial 1. The air space is therefore very slightly increased in volume, but it is possible to change the lower vial 3 numerous times before the inverted vial 1 requires replacement and the apparatus needs to be reprimed.
What I claim is:
An apparatus for feeding a multid-ose injector with liquid and preventing air from being introduced int-o the injector between injections which comprises a first stoppered container, a second stoppered container, said second container being substantially upright and said first container being substantially inverted, a holder disposed between the stoppers of said containers in contiguous relationship thereto, a liquid feed tube extending from a position inside said first container near the stopper thereof through said stopper and holder outwardly of said holder, said tube being adapted to be connected to said multidose injector, a communication tube extending from a position near the base of said first container to a position near the base of said second container through said stoppers and holder, an air inlet tube extending from within said second container just below the stopper thereof outward through said stopper and holder and a filter substantially impervious to bacteria connected to the outward end of said air inlet tube, whereby any air within the communication tube is displaced into the air space above the liquid in the inverted container and is not introduced into the 2,584,397 2/1952 Pitman 128215 X multidose injector. 2,589,728 3/1952 Pratt 128225 References Cited RICHARD A. GAUDET, Primary Examiner.
UNITED STATES PATENTS 5 DALTON TRULUCK, ROBERT E. MORGAN,
2,202,163 5/1940 Mulford et a1. 128214 Examiners-
US29989563 1962-08-03 1963-08-05 Apparatus for feeding multiple dose jet injectors Expired - Lifetime US3343538A (en)

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GB2995662A GB972939A (en) 1962-08-03 1962-08-03 Apparatus for feeding multiple dose jet injectors

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DE (1) DE1276873B (en)
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NL (1) NL296017A (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3885607A (en) * 1973-11-16 1975-05-27 Richard I Peltier Device for providing fluid communication between two sealed vessels
WO1984003445A1 (en) * 1983-03-07 1984-09-13 Univ Vanderbilt Intravenous drug administration apparatus
US4474184A (en) * 1982-09-27 1984-10-02 Advanced Technology Laboratories, Inc. Bubble trap for ultrasound scanhead
EP0126718A2 (en) * 1983-05-20 1984-11-28 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
FR2549729A1 (en) * 1982-05-27 1985-02-01 Preci Tech Ltd HYPODERMIC INJECTOR WITHOUT NEEDLE
US4623334A (en) * 1983-03-07 1986-11-18 Vanderbilt University Intravenous drug infusion apparatus
US4820269A (en) * 1983-03-07 1989-04-11 Vanderbilt University Mixer apparatus for controlling intravenous drug infusion
FR2688206A1 (en) * 1992-03-05 1993-09-10 Doryokuro Kakunenryo APPARATUS FOR TRANSFERRING A SOLUTION BETWEEN TWO HERMETIC CONTAINERS.
US5466220A (en) * 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5769138A (en) * 1996-04-01 1998-06-23 Medi-Ject Corporation Nozzle and adapter for loading medicament into an injector
US5846233A (en) * 1995-01-09 1998-12-08 Medi-Ject Corporation Coupling device for medical injection system
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US6474375B2 (en) 2001-02-02 2002-11-05 Baxter International Inc. Reconstitution device and method of use
US20040249341A1 (en) * 2003-06-06 2004-12-09 Newbrough Jerry W. Reconstitution device and method of use
US9925333B2 (en) 2013-06-18 2018-03-27 Enable Injections, Inc. Vial transfer and injection apparatus and method
US10729842B2 (en) 2012-09-24 2020-08-04 Enable Injections, Inc. Medical vial and injector assemblies and methods of use

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE7702734U1 (en) * 1977-02-01 1977-09-15 B. Braun Melsungen Ag, 3508 Melsungen REMOVAL AND VENTILATION CANNULES
FR2630010A1 (en) * 1988-04-19 1989-10-20 Bearn Mecanique Aviat Sa Needleless injection apparatus, in particular for the simultaneous injection of at least two separate products

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2202163A (en) * 1936-06-15 1940-05-28 Nat Drug Co Closure for dispensing containers
US2584397A (en) * 1945-10-03 1952-02-05 Louis K Pitman Apparatus for transferring liquid from one container to another
US2589728A (en) * 1947-10-18 1952-03-18 Edmond O Pratt Pneumatically operated irrigating apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2202163A (en) * 1936-06-15 1940-05-28 Nat Drug Co Closure for dispensing containers
US2584397A (en) * 1945-10-03 1952-02-05 Louis K Pitman Apparatus for transferring liquid from one container to another
US2589728A (en) * 1947-10-18 1952-03-18 Edmond O Pratt Pneumatically operated irrigating apparatus

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3885607A (en) * 1973-11-16 1975-05-27 Richard I Peltier Device for providing fluid communication between two sealed vessels
FR2549729A1 (en) * 1982-05-27 1985-02-01 Preci Tech Ltd HYPODERMIC INJECTOR WITHOUT NEEDLE
US4474184A (en) * 1982-09-27 1984-10-02 Advanced Technology Laboratories, Inc. Bubble trap for ultrasound scanhead
WO1984003445A1 (en) * 1983-03-07 1984-09-13 Univ Vanderbilt Intravenous drug administration apparatus
US4623334A (en) * 1983-03-07 1986-11-18 Vanderbilt University Intravenous drug infusion apparatus
US4820269A (en) * 1983-03-07 1989-04-11 Vanderbilt University Mixer apparatus for controlling intravenous drug infusion
JPH06150B2 (en) * 1983-03-07 1994-01-05 ザ ヴアンダ−ビルト ユニバ−シテイ IV drug delivery device
EP0126718A2 (en) * 1983-05-20 1984-11-28 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
EP0126718A3 (en) * 1983-05-20 1985-10-23 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
FR2688206A1 (en) * 1992-03-05 1993-09-10 Doryokuro Kakunenryo APPARATUS FOR TRANSFERRING A SOLUTION BETWEEN TWO HERMETIC CONTAINERS.
US5466220A (en) * 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5846233A (en) * 1995-01-09 1998-12-08 Medi-Ject Corporation Coupling device for medical injection system
US5891085A (en) * 1995-01-09 1999-04-06 Medi-Ject Corporation Nozzle assembly with lost motion connection for medical injector assembly
US5919159A (en) * 1995-01-09 1999-07-06 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5769138A (en) * 1996-04-01 1998-06-23 Medi-Ject Corporation Nozzle and adapter for loading medicament into an injector
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US6474375B2 (en) 2001-02-02 2002-11-05 Baxter International Inc. Reconstitution device and method of use
US20040249341A1 (en) * 2003-06-06 2004-12-09 Newbrough Jerry W. Reconstitution device and method of use
US6948522B2 (en) 2003-06-06 2005-09-27 Baxter International Inc. Reconstitution device and method of use
US10729842B2 (en) 2012-09-24 2020-08-04 Enable Injections, Inc. Medical vial and injector assemblies and methods of use
US9925333B2 (en) 2013-06-18 2018-03-27 Enable Injections, Inc. Vial transfer and injection apparatus and method
US11040138B2 (en) 2013-06-18 2021-06-22 Enable Injections, Inc. Vial transfer and injection apparatus and method

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Publication number Publication date
GB972939A (en) 1964-10-21
FR1372572A (en) 1964-09-18
NL296017A (en) 1900-01-01
DE1276873B (en) 1968-09-05

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