US3391695A - Cartridge with reflexed burstable diaphragm - Google Patents
Cartridge with reflexed burstable diaphragm Download PDFInfo
- Publication number
- US3391695A US3391695A US558399A US55839966A US3391695A US 3391695 A US3391695 A US 3391695A US 558399 A US558399 A US 558399A US 55839966 A US55839966 A US 55839966A US 3391695 A US3391695 A US 3391695A
- Authority
- US
- United States
- Prior art keywords
- diaphragm
- cartridge
- needle
- holder
- reflexed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940090045 cartridge Drugs 0.000 description 25
- 239000003814 drug Substances 0.000 description 17
- 239000012530 fluid Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000009172 bursting Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
Definitions
- a cartridge containing a medicament is provided with a plunger at one end and a thin walled resilient stopper at the other end, said stopper having a portion normally reflexed toward the plunger.
- the medicament Upon pressure being applied to the plunger, the medicament causes the reflexed portion to evert, the pressure further ballooning the resilient stopper portion until it bursts and the medicament is expelled through the ruptured portion of the stopper and through a hollow needle attached to the cartridge.
- This invention relates to cartridges such as are utilized in syringes for administering fluid medication to a subject.
- the invention relates to a cartridge or syringe wherein the cartridge or syringe may contain a medicament which it is desired to maintain normally sealed and away from a cannula carried by the cartridge or the syringe in order to prevent deleterious interaction between the medicament and the cannula or the passage to the cannula.
- the invention relates to a novel form of burstable diaphragm within the cartridge which effects the sealing relationship between the medicament and the cannula.
- the administrator of the medicament will perform an aspirating or backward movement of the plunger of the syringe, in order to draw and inspect a specimen of the fluid with which the point of the needle is in contact, this necessitating unrestricted fluid movement past the burst diaphragm.
- the diaphragms were so formed that, upon aspirating movement, the fragmentary portions remaining on the diaphragm tended to move to an obstructing position.
- FIG. 1 is a longitudinal sectional view of a cartridge and needle illustrating an embodiment of the invention.
- FIG. 2 is a plan view of the diaphragm in its normal condition.
- FIG. 1 a cartridge comprising a vial or container 10 and its associated portions, and a hollow needle 12 and its associated portions.
- the needle is pointed at its forward end, as indicated at 14, for body penetration and need not be pointed at the rear end 16.
- the needle end 16 is blunt and lies within the neck portion 18 of a needle holder or shield 20 and is fastened thereto in any conventional fashion.
- the holder is formed with a large chamber as indicated at 22 within which are located diaphragm rupturing devices 24. In the form disclosed, these devices are projections integral with the hollow holder, the holder being of plastic, rubber or like material.
- the holder is made of a transparent plastic material, such as nylon, so that it may be observed within the holder what diaphragm action occurs within the hold-er and so that the aspirated fluid may be viewed in the holder rather than in the medication containing portion. of the cartridge. The latter viewing obviously would require a greater degree of aspiration than the viewing in the holder.
- the projections 24 are formed with bevelled edges forming ridges or knife edges 26, adapted to cut into an expanding diaphragm, as will be explained.
- The, needle holder 20 is clamped to the vial in any convenient fashion, as by spinning an aluminum collar 28 over the shoulder of a terminal portion. 30 of the vial and over an annular flange 32 integral with the holder.
- the needle holder is clamped to the vial with the flange 34 of a stopper 36, preferably of soft rubber, the stopper flange being com-pressed between the open mouth of the holder and the terminal portion of the vial.
- the flange of the stopper is integral with a channeled cylinder 38 compressed in the neck of the vial 10.
- the forward end of the channel is sealed off by an expandable Wall section or diaphragm, sufliciently thin so that when a fluid in the vial is operated by a piston, as piston 42, the fluid is forced through the channel in the cylinder 38 against the diaphragm.
- the diaphragm is reflexed as indicated at 44. That is to say, the diaphragm normally has a shape such that it is concave toward the needle end of the syringe and convex toward the medicament end of the syringe.
- the diaphragm may be normally arcuate in cross section.
- the diaphragm is conical in form.
- the diaphragm Upon pressure being aplied to the medicament in the vial, the diaphragm will pop to a reverse condition, with the concavity forming a convexity and will balloon out and either burst by reason of the walls of the diaphragm becoming too thin to resist the applied pressure or by reason of contacting the knife edges 26 of the projections. Then, by reason of the resiliency of the rubber and the forces inherent in the rubber, the remnants of the diaphragm will move back more or less to the normal reflex position. Thus, subsequent aspiration would tend to open any existing aperture rather than to obstruct such aperture.
- the vial is filled with a medicament, as a liquid medicament 46, and placed within a cartridge holder, not shown, provided with a plunger rod for coupling with the piston 42, as through the intermediary of the screw 48 embedded within the piston.
- the plunger rod is then operated to force the piston 42 toward the forward end of the cart-ridge.
- the liquid within the cartridge is forced through the channel in the stopper 3-8 and will cause the diaphragm 40 to balloon out into the chamber 22 of the needle holder 20 until either the diaphragm ruptures because of internal stresses within the diaphragm or until the diaphragm ruptures by reason of engagement of the thinned diaphragm balloon wall with the projections 24.
- the sharp edge 26 of the projections ensure the rupturing of the balloon.
- Aspirating can be effected by performing a withdrawing action on the plunger rod immediately after diaphragm rupture and which rupture can be observed through the transparent holder 20. Because of the normal reflexed condition of the diaphragm, aspiration is performed much more readily since blockage of flow of blood from a patient by reason of diaphragm fragments overlapping or contacting is obviated, aspiration tending to open the burst diaphragm passage rather than closing it.
- Blocking of the passage of the needle is obviated because the tension on the thin ballooned wall of the diaphragm when it is burst will immediately draw all fragments of the wall away from the needle. It should be noted that by reason of the cutting members 24, the back end of the needle need not be sharpened, thus saving expense in the cost of manufacture of the needle, and the positioning of the rear end of the needle is not critical.
- a cartridge comprising a container, a stopper at the forward end of the container, a fluid within the container, said stopper having a resilient wall section which presents a convex face toward the fluid in the container,
- said wall section when the pressures are equalized on both sides of.
- said wall section said wall section being adapted to be flexed in an opposite direction so as to present a substantially concave face toward the fluid, ballooned, and eventually burst on application of pressure to the fluid
- said cartridge being further provided with a shield in advance of the stopper, said shield being hollow and free of obstructions for a substantial distance beyond the stopper to enable such ballooning action of the wall section to occur within the shield.
- the shield functions as a holder, a needle fixed in said holder, said stopper having a flange positioned between the neck end portion of the vial and the holder, and means for clamping together the vial, flange of the stopper and holder 4.
- the holder is provided, internally thereof, with knife edges remote from the stopper in the path of movement of a ballooning wall section.
Description
July 9, 1968 3,391,695
CARTRIDGE WITH REFLEXED BUHSTABLE DIAPHRAGM S. J. SARNOFF Filed June 17, 1966 INVENTOR S THNLEY J fi seuarF BY WM nrraeuev wxxxxc \xxxxxxxx R United States Patent 3,391,695 CARTRIDGE WITH REFLEXED BURSTABLE DIAPHRAGM Stanley J. Sarnoff, 7597 Hamden Laue, Bethesda, Nit]. 20014 Filed June 17, 1966, Ser. No. 558,399 4 Claims. (Cl. 128-218) ABSTRACT OF THE DISCLOSURE A cartridge containing a medicament is provided with a plunger at one end and a thin walled resilient stopper at the other end, said stopper having a portion normally reflexed toward the plunger. Upon pressure being applied to the plunger, the medicament causes the reflexed portion to evert, the pressure further ballooning the resilient stopper portion until it bursts and the medicament is expelled through the ruptured portion of the stopper and through a hollow needle attached to the cartridge.
This invention relates to cartridges such as are utilized in syringes for administering fluid medication to a subject. In particular, the invention relates to a cartridge or syringe wherein the cartridge or syringe may contain a medicament which it is desired to maintain normally sealed and away from a cannula carried by the cartridge or the syringe in order to prevent deleterious interaction between the medicament and the cannula or the passage to the cannula. Still more particularly, the invention relates to a novel form of burstable diaphragm within the cartridge which effects the sealing relationship between the medicament and the cannula.
Where a medicament is contained in the cartridge, it has been known in the prior art, as in Pittinger 1,288,174, Kabnick 1,943,120, Cohen et al. 2,847,996 or in Sarnoff applications Ser. No. 408,423, filed Nov. 2, 1964 and Ser. No. 447,741, filed Apr. 13, 1965, to effect the seal referred to above by means of a membrane which, when it is desired to use the contents of the cartridge, is either pierced by movement of the. hypodermic needle relative to the cartridge or by forcing or stretching the membrane into contact with the needle so that the needle may puncture the membrane. It has also been known, in the prior art, where a medicament is contained in the cartridge, as in Goold 1,455,047 and in the referred to Sarnofl disclosures, to effect communication between a fluid container and the needle by bursting a flexible diaphragm, the bursting being effected by reason of fluid pressure applied to the diaphragm to cause it to distend and finally burst because of wall weakness or, as in the case of the Sarnoff disclosures, by engaging puncturing projections in the path of movement by the ballooning diaphragm. In most instances, prior to medication injection into a patient and in order to determine whether the point of the needle, after skin penetration, has entered the proper area, the administrator of the medicament will perform an aspirating or backward movement of the plunger of the syringe, in order to draw and inspect a specimen of the fluid with which the point of the needle is in contact, this necessitating unrestricted fluid movement past the burst diaphragm. However, prior to this invention, the diaphragms were so formed that, upon aspirating movement, the fragmentary portions remaining on the diaphragm tended to move to an obstructing position. This would be particularly so when the ballooning of the diaphragm caused a stretching action of the diaphragm and imparted a more or less permanent set thereto, whereby upon release from pressure the parts of the ruptured diaphragm would overlap to prevent aspiration of fluid from the patient into the syringe.
3,391,695 Patented July 9, 1968 It is therefore an object of this invention to provide a diaphragm construction such that an obstruction of fluid movement due to diaphragm action will be obviated and resistance to aspiration effects is reduced.
For a fuller understanding of the invention, attention is directed to the following specification and the accompanying drawing in which:
FIG. 1 is a longitudinal sectional view of a cartridge and needle illustrating an embodiment of the invention; and,
FIG. 2 is a plan view of the diaphragm in its normal condition.
Now referring to the drawings in greater detail, there is illustrated in FIG. 1 a cartridge comprising a vial or container 10 and its associated portions, and a hollow needle 12 and its associated portions. The needle is pointed at its forward end, as indicated at 14, for body penetration and need not be pointed at the rear end 16. As illustrated, the needle end 16 is blunt and lies within the neck portion 18 of a needle holder or shield 20 and is fastened thereto in any conventional fashion. The holder is formed with a large chamber as indicated at 22 within which are located diaphragm rupturing devices 24. In the form disclosed, these devices are projections integral with the hollow holder, the holder being of plastic, rubber or like material. Preferably, the holder is made of a transparent plastic material, such as nylon, so that it may be observed within the holder what diaphragm action occurs within the hold-er and so that the aspirated fluid may be viewed in the holder rather than in the medication containing portion. of the cartridge. The latter viewing obviously would require a greater degree of aspiration than the viewing in the holder. The projections 24 are formed with bevelled edges forming ridges or knife edges 26, adapted to cut into an expanding diaphragm, as will be explained.
The, needle holder 20 is clamped to the vial in any convenient fashion, as by spinning an aluminum collar 28 over the shoulder of a terminal portion. 30 of the vial and over an annular flange 32 integral with the holder. The needle holder is clamped to the vial with the flange 34 of a stopper 36, preferably of soft rubber, the stopper flange being com-pressed between the open mouth of the holder and the terminal portion of the vial.
The flange of the stopper is integral with a channeled cylinder 38 compressed in the neck of the vial 10. The forward end of the channel is sealed off by an expandable Wall section or diaphragm, sufliciently thin so that when a fluid in the vial is operated by a piston, as piston 42, the fluid is forced through the channel in the cylinder 38 against the diaphragm. The diaphragm is reflexed as indicated at 44. That is to say, the diaphragm normally has a shape such that it is concave toward the needle end of the syringe and convex toward the medicament end of the syringe. The diaphragm may be normally arcuate in cross section. Preferably the diaphragm, as illustrated in the drawings, is conical in form. Upon pressure being aplied to the medicament in the vial, the diaphragm will pop to a reverse condition, with the concavity forming a convexity and will balloon out and either burst by reason of the walls of the diaphragm becoming too thin to resist the applied pressure or by reason of contacting the knife edges 26 of the projections. Then, by reason of the resiliency of the rubber and the forces inherent in the rubber, the remnants of the diaphragm will move back more or less to the normal reflex position. Thus, subsequent aspiration would tend to open any existing aperture rather than to obstruct such aperture.
In the use of the cartridge, the vial is filled with a medicament, as a liquid medicament 46, and placed within a cartridge holder, not shown, provided with a plunger rod for coupling with the piston 42, as through the intermediary of the screw 48 embedded within the piston. The plunger rod is then operated to force the piston 42 toward the forward end of the cart-ridge. The liquid within the cartridge is forced through the channel in the stopper 3-8 and will cause the diaphragm 40 to balloon out into the chamber 22 of the needle holder 20 until either the diaphragm ruptures because of internal stresses within the diaphragm or until the diaphragm ruptures by reason of engagement of the thinned diaphragm balloon wall with the projections 24. The sharp edge 26 of the projections ensure the rupturing of the balloon. Thus, 1
free passage is now aflorded for the medicament from the vial and out of the needle. Aspirating can be effected by performing a withdrawing action on the plunger rod immediately after diaphragm rupture and which rupture can be observed through the transparent holder 20. Because of the normal reflexed condition of the diaphragm, aspiration is performed much more readily since blockage of flow of blood from a patient by reason of diaphragm fragments overlapping or contacting is obviated, aspiration tending to open the burst diaphragm passage rather than closing it. Blocking of the passage of the needle is obviated because the tension on the thin ballooned wall of the diaphragm when it is burst will immediately draw all fragments of the wall away from the needle. It should be noted that by reason of the cutting members 24, the back end of the needle need not be sharpened, thus saving expense in the cost of manufacture of the needle, and the positioning of the rear end of the needle is not critical.
Having thus described the invention, what is claimed is:
1. A cartridge comprising a container, a stopper at the forward end of the container, a fluid within the container, said stopper having a resilient wall section which presents a convex face toward the fluid in the container,
when the pressures are equalized on both sides of. said wall section, said wall section being adapted to be flexed in an opposite direction so as to present a substantially concave face toward the fluid, ballooned, and eventually burst on application of pressure to the fluid, said cartridge being further provided with a shield in advance of the stopper, said shield being hollow and free of obstructions for a substantial distance beyond the stopper to enable such ballooning action of the wall section to occur within the shield.
2. The cartridge of claim 1 wherein the cartridge has a neck and the diaphragm has a channeled cylinder fitted in the neck, the wall section lying in said channeled cylinder.
3. The cartridge of claim 1 wherein the shield functions as a holder, a needle fixed in said holder, said stopper having a flange positioned between the neck end portion of the vial and the holder, and means for clamping together the vial, flange of the stopper and holder 4. The cartridge of claim 3 wherein the holder is provided, internally thereof, with knife edges remote from the stopper in the path of movement of a ballooning wall section.
References Cited UNITED STATES PATENTS 1,388,946 8/1921 Goold 128-216 2,646,798 7/1953 Brown 128-218 2,735,429 2/1956 Huber 128218 3,308,821 3/1967 Shields 128-218 FOREIGN PATENTS 882,600 7/ 1953 Germany.
RICHARD A. GAUDET, Primary Examiner.
D. L. BAKER, M. F. MAJESTIC, Assistant Examiners.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US558399A US3391695A (en) | 1966-06-17 | 1966-06-17 | Cartridge with reflexed burstable diaphragm |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US558399A US3391695A (en) | 1966-06-17 | 1966-06-17 | Cartridge with reflexed burstable diaphragm |
Publications (1)
Publication Number | Publication Date |
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US3391695A true US3391695A (en) | 1968-07-09 |
Family
ID=24229392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US558399A Expired - Lifetime US3391695A (en) | 1966-06-17 | 1966-06-17 | Cartridge with reflexed burstable diaphragm |
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Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1934117A1 (en) * | 1968-08-09 | 1970-02-26 | Sarnoff Stanley Jay | Injection gun for medical applications |
US3712301A (en) * | 1971-01-11 | 1973-01-23 | Survival Technology | Gun type hypodermic injector with rapid cartridge displacement within holder |
US4051851A (en) * | 1976-03-31 | 1977-10-04 | Tischlinger Edward A | Diaphragm assembly for a medicament dispensing unit |
DE2721545A1 (en) * | 1976-05-14 | 1977-11-24 | Philips Nv | INJECTION SYRINGE |
US4072149A (en) * | 1976-08-09 | 1978-02-07 | Tischlinger Edward A | Nose cap and diaphragm assembly for injector |
US4291695A (en) * | 1976-04-05 | 1981-09-29 | Duphar International Research B.V. | Disposable injection syringe |
US4394863A (en) * | 1981-10-23 | 1983-07-26 | Survival Technology, Inc. | Automatic injector with cartridge having separate sequentially injectable medicaments |
US4518384A (en) * | 1983-06-17 | 1985-05-21 | Survival Technology, Inc. | Multiple medicament cartridge clip and medicament discharging device therefor |
EP0160711A1 (en) * | 1984-05-03 | 1985-11-13 | Bünder Glas GmbH | Injection syringe |
WO1986006966A1 (en) * | 1985-05-20 | 1986-12-04 | Survival Technology, Inc. | Plural dosage injector with by-pass fitment |
US4658830A (en) * | 1984-08-08 | 1987-04-21 | Survival Technology, Inc. | Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms |
US4678461A (en) * | 1984-11-01 | 1987-07-07 | Survival Technology, Inc. | Automatic injector with improved glass container protector |
US4795433A (en) * | 1985-05-20 | 1989-01-03 | Survival Technology, Inc. | Automatic injector for emergency treatment |
US4832682A (en) * | 1984-08-08 | 1989-05-23 | Survival Technology, Inc. | Injection method and apparatus with electrical blood absorbing stimulation |
US5085642A (en) * | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use autoinjector |
US5102393A (en) * | 1989-07-17 | 1992-04-07 | Survival Technology, Inc. | Autoinjector converted from intramuscular to subcutaneous mode of injection |
WO2001062317A1 (en) * | 2000-02-25 | 2001-08-30 | Ultradent Products, Inc. | Syringe apparatus with a rupturable membrane and related methods |
US20050171477A1 (en) * | 2002-05-23 | 2005-08-04 | Seedlings Life Science Ventures | Apparatus and method for rapid auto-injection of medication |
US20080039795A1 (en) * | 2006-08-09 | 2008-02-14 | Slate John B | Injection System With Hidden Needles |
WO2017089280A1 (en) * | 2015-11-27 | 2017-06-01 | Sanofi-Aventis Deutschland Gmbh | Injection apparatus |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1388946A (en) * | 1920-05-18 | 1921-08-30 | Semi Unit Corp | Hypodermic syringe |
DE882600C (en) * | 1951-12-04 | 1953-07-09 | Alfons Kiesl | Injection ampoule |
US2646798A (en) * | 1950-09-21 | 1953-07-28 | Frank E Brown | Cartridge syringe |
US2735429A (en) * | 1956-02-21 | Hypodermic syringes | ||
US3308821A (en) * | 1964-03-23 | 1967-03-14 | Walter A Shields | Disposable hypodermic syringes |
-
1966
- 1966-06-17 US US558399A patent/US3391695A/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2735429A (en) * | 1956-02-21 | Hypodermic syringes | ||
US1388946A (en) * | 1920-05-18 | 1921-08-30 | Semi Unit Corp | Hypodermic syringe |
US2646798A (en) * | 1950-09-21 | 1953-07-28 | Frank E Brown | Cartridge syringe |
DE882600C (en) * | 1951-12-04 | 1953-07-09 | Alfons Kiesl | Injection ampoule |
US3308821A (en) * | 1964-03-23 | 1967-03-14 | Walter A Shields | Disposable hypodermic syringes |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1934117A1 (en) * | 1968-08-09 | 1970-02-26 | Sarnoff Stanley Jay | Injection gun for medical applications |
US3712301A (en) * | 1971-01-11 | 1973-01-23 | Survival Technology | Gun type hypodermic injector with rapid cartridge displacement within holder |
US4051851A (en) * | 1976-03-31 | 1977-10-04 | Tischlinger Edward A | Diaphragm assembly for a medicament dispensing unit |
US4291695A (en) * | 1976-04-05 | 1981-09-29 | Duphar International Research B.V. | Disposable injection syringe |
DE2721545A1 (en) * | 1976-05-14 | 1977-11-24 | Philips Nv | INJECTION SYRINGE |
US4072149A (en) * | 1976-08-09 | 1978-02-07 | Tischlinger Edward A | Nose cap and diaphragm assembly for injector |
US4394863A (en) * | 1981-10-23 | 1983-07-26 | Survival Technology, Inc. | Automatic injector with cartridge having separate sequentially injectable medicaments |
US4518384A (en) * | 1983-06-17 | 1985-05-21 | Survival Technology, Inc. | Multiple medicament cartridge clip and medicament discharging device therefor |
EP0160711A1 (en) * | 1984-05-03 | 1985-11-13 | Bünder Glas GmbH | Injection syringe |
US4832682A (en) * | 1984-08-08 | 1989-05-23 | Survival Technology, Inc. | Injection method and apparatus with electrical blood absorbing stimulation |
US4658830A (en) * | 1984-08-08 | 1987-04-21 | Survival Technology, Inc. | Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms |
US4678461A (en) * | 1984-11-01 | 1987-07-07 | Survival Technology, Inc. | Automatic injector with improved glass container protector |
US4723937A (en) * | 1985-05-20 | 1988-02-09 | Survival Technology, Inc. | Plural dosage automatic injector with a by-pass fitment |
US4795433A (en) * | 1985-05-20 | 1989-01-03 | Survival Technology, Inc. | Automatic injector for emergency treatment |
WO1986006966A1 (en) * | 1985-05-20 | 1986-12-04 | Survival Technology, Inc. | Plural dosage injector with by-pass fitment |
US5085642A (en) * | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use autoinjector |
US5102393A (en) * | 1989-07-17 | 1992-04-07 | Survival Technology, Inc. | Autoinjector converted from intramuscular to subcutaneous mode of injection |
WO2001062317A1 (en) * | 2000-02-25 | 2001-08-30 | Ultradent Products, Inc. | Syringe apparatus with a rupturable membrane and related methods |
US6979316B1 (en) | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
US20050171477A1 (en) * | 2002-05-23 | 2005-08-04 | Seedlings Life Science Ventures | Apparatus and method for rapid auto-injection of medication |
US7658724B2 (en) | 2002-05-23 | 2010-02-09 | Seedings Life Science Ventures LLC | Apparatus and method for rapid auto-injection of medication |
US20080039795A1 (en) * | 2006-08-09 | 2008-02-14 | Slate John B | Injection System With Hidden Needles |
US7618396B2 (en) * | 2006-08-09 | 2009-11-17 | Avant Medical Corp. | Injection system with hidden needles |
WO2017089280A1 (en) * | 2015-11-27 | 2017-06-01 | Sanofi-Aventis Deutschland Gmbh | Injection apparatus |
CN108495670A (en) * | 2015-11-27 | 2018-09-04 | 赛诺菲-安万特德国有限公司 | Injection device |
US20180344933A1 (en) * | 2015-11-27 | 2018-12-06 | Sanofi-Aventis Deutschland Gmbh | Injection apparatus |
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