US3399536A - Device for varying the blood temperature - Google Patents

Device for varying the blood temperature Download PDF

Info

Publication number
US3399536A
US3399536A US612849A US61284967A US3399536A US 3399536 A US3399536 A US 3399536A US 612849 A US612849 A US 612849A US 61284967 A US61284967 A US 61284967A US 3399536 A US3399536 A US 3399536A
Authority
US
United States
Prior art keywords
blood
flow
space
varying
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US612849A
Inventor
Walz Heinz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Original Assignee
Siemens AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens AG filed Critical Siemens AG
Application granted granted Critical
Publication of US3399536A publication Critical patent/US3399536A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25BREFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B21/00Machines, plants or systems, using electric or magnetic effects
    • F25B21/02Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/36General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606General characteristics of the apparatus related to heating or cooling cooled
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/36General characteristics of the apparatus related to heating or cooling
    • A61M2205/3673General characteristics of the apparatus related to heating or cooling thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors

Definitions

  • Arism'er har s mscrbs'uiie -'I-he blood' tem-perature varying "device has-"abandshaped flow-through space extending across substantially the entire s'urface'on one 'side' of -a'Peltier'block.
  • the space has a width manytimes greater than-the thickness thereof and is provided with an inlet and an outlet "at the extremities thereof.
  • The-space has fan-shaped transition portions "respectively outwardly flaring from and inwardly narrowing to the inlet and outlet andiscurved substantially in accordance with the stream lines of blood I flowing through the space. Furthermore, the spaceis defined by smoothly polished surfaces.
  • My invention relates to device for varying the 'blood temperature and more particularly a device of; that type which employs a Peltier block connected on the warm side thereof with cooling 'fins' and onjth'e cold side there 'gfwitha flow-through cooler actingas a heat. exchanger, both thecooling fins andthe flow-through cooler being thermally conductive with and electrically insulated from the Peltier block.
  • Modern-surgical operating practice has sought for a long itime' to carry out anl operation underhypothermal conditions wherein the. temperature of the field of the operation is lowered toa v lue bel wjgso1o Under-such subcooled'cond ition, the ox gen, Iequirement'and this me ho i 'oi all tisf u fi s re u t ai aq a ex en and ;-the supply, of oxygenfto the e'sl Consequently rcfn'g no m-3 .3 m 'adt fi-lr j rrb uc L ofsubcooling in the lieldlof the operation, it has already been known to reducethe tempef'ature of the entire body, For this purpose, thebody i'sf 'cooled" from the eitterior thereof with ice packs, coolant" coils or coolingmats J traversed by a cooling liquid.
  • An extracorporeal circulation .system ,or loop portion has to be provided by means of which blood is tapped only from the artery-supplying the 3,399,536 Patented Sept.' 3 1968 fieldof the operation and, after being cooled, is re turned'to this artery.
  • a flow-through cooler which is connected 'intothe extracorporeal portion of the circulation system presents itself as a suitable't'echnical solution of this problem. From the medical point of view, several technicalrequirements must be imposed upon these flowthroug'h coolers. The flow through the'cooler must take place without any congestion or obstruction in blind corners' thereof, in order to prevent coagulat'ion of-the blood. Microscopically.
  • the blood temperature must be maintained as constant as possible after the blood has passed the cooler flow-th'rough stage. Therefore, the occurrence of temperature gradients within the flow 'as it'passes through the cooling stage must be avoided as much as possible.
  • the flow-through space in the cooler must be well scaled to prevent the occurrence of interchange processes between the blood and the surroundings.
  • the material from which the flow-through cooler is made must be corrosion-resistant, capable of sterilization and boilable. 7
  • a device for varying the blood temperature which comprises means having a flowthrough space extending in the shape of a band across substantially the entire surface on one side of a Peltier block and having a width many times greater than the thickness thereof and an outlet from and an' inlet to the flow-through space.
  • the flow-through space has 'a fanshaped transition portion respectively flaring" outwardly from the inlet and narrowing toward the outlet.
  • the transition portion is curved substantially in accordance with the stream lines of blood flowing through the space.
  • the space is defined by surfaces that are smoothly polished.
  • the cooled blood flowing back from the field of the operation or at least a portion thereof is conducted into a second extracorporeal circulating system adjacent the warm side of the block so as to reheat it at that location.
  • the temperature of the entire body thus remains practically independent of the subcooling of the field of the operation. Consequently, in accordance with this further feature of my invention, there is provided a second heat exchanger, with a flow-through space having the aforementioned features, at the warm side of the Peltier block, in the place of at least part of the cooling fins, for heating the blood.
  • the heat exchangers are made of corrosion-resistant metal; furthermore, the flow-through space in each heat exchanger is sealed by means of a sealing member or gasket resistant to boiling, and the heat exchangers are removable. Also in accordance with a feature of my invention, I provide a regulating device which assures a specific constant temperature of the blood after it has passed through the flowthrough stage.
  • FIG. 1 is a diagrammatic longitudinal view partly in section of an embodiment of the device for varying the blood temperature constructed in accordance with my invention
  • FIG. 2 is a plan view of FIG. 1 with the cover plate on the right-hand side of FIG. I removed;
  • FIG. 3 is another diagrammatic longitudinal sectional view of a second embodiment of the device of FIG. 1;
  • FIG. 4 is a diagrammatic view of an extracorporeal portion of a blood circulating system in which the device of my invention is connected;
  • FIG. 5 is a diagrammatic view of two extracorporeal portions of'circulating systems in which my device is connected.
  • FIGS. 1 and 2 there is shown a Peltier block formed of pand n-conductive semiconductor members 1, contact bridges 2 therebetween and heat exchanger plates 3. Cooling fins 10 are superimposed on the heat exchanger plate 3 at the'warm side of the Peltier block and are ventilated by a fan 11 to remove the heat therefrom.
  • a heat exchanger 4 is mounted on the heat-exchanger plate 3 at the 'cold side of the Peltier block and is provided with a flow-through space 6 that is closed by a cover plate 5, suitably secured thereon.
  • the flow-through space 6 is provided with an inlet opening 7 and an outlet opening 8 at the extremities thereof.
  • the flow-through space is sealed by a gasket 9.
  • the heat exchanger of FIG. 1 is shown with the cover 5 removed.
  • the cooling fins 10 of the embodiment of FIG. 1 are replaced by a second heat exchanger.
  • the second heat exchanger comprises a main plate 4,, a flow-through space 6', an inlet and an outletopening 7' and 8' respectively, and a cover plate 5' substantially of the same construction and function as the corresponding members of the first-mentioned heat exchanger of the embodiment of FIG. 1.
  • FIG. 4 schematically shows an extracorporeal portion of ablood circulation system in which the device of my invention is inserted.
  • the artery 10 is interrupted at a location 13 and the blood from the artery 10 is conducted through a bypass tube 11 to the device 12 for cooling the blood.
  • the bypass tube 11 can be made of suitable plastic material.
  • the device 12 of my invention for cooling the blood corresponds to the device shown in greater detail in-FIGS. 1 and 2 and described hereinbefore.
  • the blood flows from the portion of the artery 10, located at the left-hand side of FIG. 4, through the band-shaped flow-through space of the cooling device 12 and is returned to the artery 10 portion at the right-hand side of FIG. '4. In the field of the oper-j ation, a temperature reduction to about 15 C. is obtained thereby.
  • FIG. 5 there are shown two extracorporeal portions of a blood circulating system.
  • the first portion of the blood circulating system is tapped with the bypass tube 11 from the artery 10 which supplies the field 15,- having the capillary vessels 16, :wherein the surgical operation is to be performed.
  • a device 14 constructed in accordance with my invention for cooling the blood.
  • the device 14 corresponds to the embodiment shown in FIG. 3 in detail, wherein a second flow-through cooler or heat exchanger for reheating the blood is superposed on the warm side of the Peltier block.
  • the blood is conducted through a bypass tube 18 out of a portion of a vein 17 which is broken at a location 19, and is returned after flowing through the device 14 to the vein 17 at the righthand side of FIG. 5.
  • the blood flowing back from the field of the operation or at least a portion thereof is reheated before it is returned to the circulation system proper of the body. The occurrence of damage to the entire organism due to subcooling of a field of an operation need no longer be feared when using this device of my invention.
  • Device for varying blood temperature comprising a Peltier block having a warm side and a cold side, a flow-through heat exchanger connected to one of said sides of'said Peltier block in thermal conduction therewith and electrically insulated therefrom, said heat exchanger having a flow-through space traversible .by a flow of blood, said space extending band-shaped over substantially,the entire area of the Peltier block on one of.
  • said sides thereof and having a width many times greater than the thickness thereof, and a blood inlet to and outlet from said flow-through space located at extremities thereof, said space being defined by smoothly polished surfaces and having fan-shaped transition portions respectively flaring from said inlet and narrowing to said outlet, said flow-through space having corners that are all rounded in outline, and said fan-shaped portions being defined by lateral surface at the flaring sides thereof having a given degree of inclination cooperating with said rounded corners for avoiding stagnation of blood flowing through said space.
  • Blood-temperature varying device wherein said flow-through heat exchanger is connected to said cold side of said Peltier block, and cooling fins are connected to the warm side of said Peltier block in heat conductive and electrically insulating contact therewith.
  • Blood-temperature varying device including a second flow-through heat exchanger substantially similar to said first-mentioned heat exchanger and being similarly connected to the other side of said Peltier block.

Description

Sept. 3, 1968 E H. WALZ DEvIcE FOR VARYING THE BLOOD TEMPERATURE Filed Jan. 51. 1967 2 Sheets-Shet 1 Sept. 3, 1968 H. WALZ DEVICE FOR VARYING THE BLOOD TEMPERATURE Filed Jan. 51. 1967 2 Sheets-Sheet 2 fill/11A! Fig; 5
.Unird State Farm My r; 7:. I: 1 I DEVICE FOR VARYING'THE BLOOD TEMPERATURE Heinz Walz,Erlangen-,Germany, assignor to. Siemens Aktiengesellschaft, a corporation of. Germany. Filed Jan. 31,1967, ser. N 612,849 Claims priority, application Germany, Feb. 2 1966,
Arism'er har s mscrbs'uiie -'I-he blood' tem-perature varying "device has-"abandshaped flow-through space extending across substantially the entire s'urface'on one 'side' of -a'Peltier'block. The space has a width manytimes greater than-the thickness thereof and is provided with an inlet and an outlet "at the extremities thereof. The-space has fan-shaped transition portions "respectively outwardly flaring from and inwardly narrowing to the inlet and outlet andiscurved substantially in accordance with the stream lines of blood I flowing through the space. Furthermore, the spaceis defined by smoothly polished surfaces.
1 My invention relates to device for varying the 'blood temperature and more particularly a device of; that type which employs a Peltier block connected on the warm side thereof with cooling 'fins' and onjth'e cold side there 'gfwitha flow-through cooler actingas a heat. exchanger, both thecooling fins andthe flow-through cooler being thermally conductive with and electrically insulated from the Peltier block. v
Modern-surgical operating practice has sought for a long itime' to carry out anl operation underhypothermal conditions wherein the. temperature of the field of the operation is lowered toa v lue bel wjgso1o Under-such subcooled'cond ition, the ox gen, Iequirement'and this me ho i 'oi all tisf u fi s re u t ai aq a ex en and ;-the supply, of oxygenfto the e'sl Consequently rcfn'g no m-3 .3 m 'adt fi-lr j rrb uc L ofsubcooling in the lieldlof the operation, it has already been known to reducethe tempef'ature of the entire body, For this purpose, thebody i'sf 'cooled" from the eitterior thereof with ice packs, coolant" coils or coolingmats J traversed by a cooling liquid. By these means, subcooling to 15to20 'Q.. ha's been effected. Thejmost critical phase forfth is treatment s jthe'rjeyv ming of lthebody. The possibility of 'par'tial residual amag'e 'to 'the body or of fatal termin'ation Qf f the"pperation cannot be excluded. This'disadvantage c zbul d' greatly avoided if it were not" necessary to "subcoolftlieferitire body to the suh cooled temperatureldesired for thei fiel d of the operation. It would be ne.cessary',in' this regard,' to,f,have a cooling capability effective only in that portion of the blood circulating system with which ,the field of the operation is provided. subcooling can be achieved thereby that is effectiveonly in' the field of the operation and by means of which the metabolism of the organ on which the operation is to be performed can be reduced. At most, the temperature of the entire body is thereby reduced only a few degrees since only a small quantity of'cooled blood is required. t H .--The modification of the blood in an extracorporeal circulation system is. already.known from the heart-lung machine. For the problem aforementioned herein, the entireblood circulation system does not, however, have to be treated or modified. An extracorporeal circulation .system ,or loop portion has to be provided by means of which blood is tapped only from the artery-supplying the 3,399,536 Patented Sept.' 3 1968 fieldof the operation and, after being cooled, is re turned'to this artery. A flow-through cooler which is connected 'intothe extracorporeal portion of the circulation system presents itself as a suitable't'echnical solution of this problem. From the medical point of view, several technicalrequirements must be imposed upon these flowthroug'h coolers. The flow through the'cooler must take place without any congestion or obstruction in blind corners' thereof, in order to prevent coagulat'ion of-the blood. Microscopically. small, sharp irregularities in the surface of the'fiow-through space'are to be avoided so thatno damage can occur mechanically to the constituents of the blood. Further-more, the blood temperature must be maintained as constant as possible after the blood has passed the cooler flow-th'rough stage. Therefore, the occurrence of temperature gradients within the flow 'as it'passes through the cooling stage must be avoided as much as possible. "In addition, the flow-through space in the cooler must be well scaled to prevent the occurrence of interchange processes between the blood and the surroundings. The material from which the flow-through cooler is made must be corrosion-resistant, capable of sterilization and boilable. 7
These requirements cannot be met by cooling the flowthrough passage of the blood with water or any other liquid. Due to the limited heat exchange with such liquid coolants, a long cooling coil must be employed for the blood, and the formation of congested or obstructed locations and consequent coagulation of the blood is accordingly unable to be prevented therein. Also, when using a Peltier block for cooling the flow-through fluid, all of the aforementioned requirements can be met only if specific technical measures have been taken into consideration. In a Peltier block, many thermoelectric elements are combined so that the cold and the warm soldering locations thereof lie in one plane, respectively, namely the cold or warm side of the Peltier block. A liquid can be cooled in a flow-through space which is connected with the cold side of the block. However, to cool blood, the flow-through space must be of such construction that it meets the aforementioned conditions for avoiding the coagulation thereof.
It is accordingly an object of my invention to provide a device for varying the blood temperature which avoids the aforementioned disadvantages. More particularly, objects of my invention are to provide such a device as will avoid the possibility of obstruction of the blood and resulting coagulation thereof. r
With the foregoing and other objects in view, I provide in accordance with my invention a device for varying the blood temperature which comprises means having a flowthrough space extending in the shape of a band across substantially the entire surface on one side of a Peltier block and having a width many times greater than the thickness thereof and an outlet from and an' inlet to the flow-through space. The flow-through space has 'a fanshaped transition portion respectively flaring" outwardly from the inlet and narrowing toward the outlet. The transition portion is curved substantially in accordance with the stream lines of blood flowing through the space. Also, the spaceis defined by surfaces that are smoothly polished. I
In accordance with a further feature of my invention the cooled blood flowing back from the field of the operation or at least a portion thereof is conducted into a second extracorporeal circulating system adjacent the warm side of the block so as to reheat it at that location. The temperature of the entire body thus remains practically independent of the subcooling of the field of the operation. Consequently, in accordance with this further feature of my invention, there is provided a second heat exchanger, with a flow-through space having the aforementioned features, at the warm side of the Peltier block, in the place of at least part of the cooling fins, for heating the blood.- 1
Other features of my invention are that the heat exchangers are made of corrosion-resistant metal; furthermore, the flow-through space in each heat exchanger is sealed by means of a sealing member or gasket resistant to boiling, and the heat exchangers are removable. Also in accordance with a feature of my invention, I provide a regulating device which assures a specific constant temperature of the blood after it has passed through the flowthrough stage.
Other features which are considered as characteristic for the invention are set forth in the appended claims.
Although the invention is illustrated and described herein as embodied in device for varying the blood temperature, it is nevertheless not intended to be limited to the details shown, since various modifications and structural changes may be made therein without departing from the spirit of the invention and within the scope and range of equivalents of the claims.
The construction and method of operation of the invention, however, together with additional objects and advantages thereof, will be best understood from the following description of specific embodiments when read in connection with the accompanying drawings, in which:
FIG. 1 is a diagrammatic longitudinal view partly in section of an embodiment of the device for varying the blood temperature constructed in accordance with my invention;
FIG. 2 is a plan view of FIG. 1 with the cover plate on the right-hand side of FIG. I removed;
FIG. 3 is another diagrammatic longitudinal sectional view of a second embodiment of the device of FIG. 1;
FIG. 4 is a diagrammatic view of an extracorporeal portion of a blood circulating system in which the device of my invention is connected; and
FIG. 5 is a diagrammatic view of two extracorporeal portions of'circulating systems in which my device is connected.
In the hereinafter described embodiments approximately' one-half liter of blood per minute is cooled to C., and with the second embodiment shown in FIG. 3, the same quantity of blood that is thus cooled is again heated to body temperature.
Referring now to the drawings and first particularly to FIGS. 1 and 2 thereof, there is shown a Peltier block formed of pand n-conductive semiconductor members 1, contact bridges 2 therebetween and heat exchanger plates 3. Cooling fins 10 are superimposed on the heat exchanger plate 3 at the'warm side of the Peltier block and are ventilated by a fan 11 to remove the heat therefrom. A heat exchanger 4 is mounted on the heat-exchanger plate 3 at the 'cold side of the Peltier block and is provided with a flow-through space 6 that is closed by a cover plate 5, suitably secured thereon. The flow-through space 6 is provided with an inlet opening 7 and an outlet opening 8 at the extremities thereof. The flow-through space is sealed by a gasket 9. In the plan view of FIG. 2, the heat exchanger of FIG. 1 is shown with the cover 5 removed.
From both FIGS. 1 and 2 it is seen that dead or blind corners in the flow path of the blood, which might tend to cause congestion or stagnation of the blood, are avoided due to the band-shaped structure of the flowthrough space, owing to the rounding or curving of the corners thereof and due to the fan-shaped widening or broadening of the flow-through space adjacent the inlet and outlet openings 7 and 8 respectively. Due to the planar or flat shape of the flow-through space 6, the production of a temperature gradient transverse to the flow direction is, furthermore, prevented.
In the second embodiment of FIG. 3, the cooling fins 10 of the embodiment of FIG. 1 are replaced by a second heat exchanger. The second heat exchanger comprises a main plate 4,, a flow-through space 6', an inlet and an outletopening 7' and 8' respectively, and a cover plate 5' substantially of the same construction and function as the corresponding members of the first-mentioned heat exchanger of the embodiment of FIG. 1. A plan view of the heat exchanger shown on the left-hand side of FIG. 3, when the cover 5 thereof is removed, substantially corresponds to the plan view shown in FIG. 2.
FIG. 4 schematically shows an extracorporeal portion of ablood circulation system in which the device of my invention is inserted. It is to be assumed that the field of the operation is supplied through the artery 10. The artery 10 is interrupted at a location 13 and the blood from the artery 10 is conducted through a bypass tube 11 to the device 12 for cooling the blood. The bypass tube 11 can be made of suitable plastic material. The device 12 of my invention for cooling the blood corresponds to the device shown in greater detail in-FIGS. 1 and 2 and described hereinbefore. The blood flows from the portion of the artery 10, located at the left-hand side of FIG. 4, through the band-shaped flow-through space of the cooling device 12 and is returned to the artery 10 portion at the right-hand side of FIG. '4. In the field of the oper-j ation, a temperature reduction to about 15 C. is obtained thereby.
In FIG. 5, there are shown two extracorporeal portions of a blood circulating system. The first portion of the blood circulating system is tapped with the bypass tube 11 from the artery 10 which supplies the field 15,- having the capillary vessels 16, :wherein the surgical operation is to be performed. In this external portion 11 of the circulating system, there is again inserted a device 14 constructed in accordance with my invention for cooling the blood. The device 14 corresponds to the embodiment shown in FIG. 3 in detail, wherein a second flow-through cooler or heat exchanger for reheating the blood is superposed on the warm side of the Peltier block. By means of this second flow-through cooler, the blood is conducted through a bypass tube 18 out of a portion of a vein 17 which is broken at a location 19, and is returned after flowing through the device 14 to the vein 17 at the righthand side of FIG. 5. In the second heat exchanger of the device 4, the blood flowing back from the field of the operation or at least a portion thereof is reheated before it is returned to the circulation system proper of the body. The occurrence of damage to the entire organism due to subcooling of a field of an operation need no longer be feared when using this device of my invention.
Iciaim:
1. Device for varying blood temperature comprising a Peltier block having a warm side and a cold side, a flow-through heat exchanger connected to one of said sides of'said Peltier block in thermal conduction therewith and electrically insulated therefrom, said heat exchanger having a flow-through space traversible .by a flow of blood, said space extending band-shaped over substantially,the entire area of the Peltier block on one of. said sides thereof and having a width many times greater than the thickness thereof, and a blood inlet to and outlet from said flow-through space located at extremities thereof, said space being defined by smoothly polished surfaces and having fan-shaped transition portions respectively flaring from said inlet and narrowing to said outlet, said flow-through space having corners that are all rounded in outline, and said fan-shaped portions being defined by lateral surface at the flaring sides thereof having a given degree of inclination cooperating with said rounded corners for avoiding stagnation of blood flowing through said space.
2. Blood-temperature varying device according to claim 1, wherein said flow-through heat exchanger is connected to said cold side of said Peltier block, and cooling fins are connected to the warm side of said Peltier block in heat conductive and electrically insulating contact therewith.
3. Blood-temperature varying device according to claim 1, wherein said heat exchanger is formed of corrosion-resistant metal.
4. Blood-temperature varying device according to claim 1, wherein said flow-through space of said heat exchanger is sealed by a gasket resistant to boiling.
5. Blood-temperature varying device according to claim 1 including a second flow-through heat exchanger substantially similar to said first-mentioned heat exchanger and being similarly connected to the other side of said Peltier block.
6. Blood-temperature varying device according to able.
References Cited UNITED STATES PATENTS Nichols 165--170 Rich 62-3 Kistler 623 Ryan 62-3 Hirschhorn 623 Gonzalez 62-3 WILLIAM I WYE, Primary Examiner.
US612849A 1966-02-02 1967-01-31 Device for varying the blood temperature Expired - Lifetime US3399536A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DES0101757 1966-02-02

Publications (1)

Publication Number Publication Date
US3399536A true US3399536A (en) 1968-09-03

Family

ID=7523979

Family Applications (1)

Application Number Title Priority Date Filing Date
US612849A Expired - Lifetime US3399536A (en) 1966-02-02 1967-01-31 Device for varying the blood temperature

Country Status (7)

Country Link
US (1) US3399536A (en)
BE (1) BE693048A (en)
CH (1) CH460064A (en)
DE (1) DE1501134B2 (en)
FR (1) FR1509763A (en)
GB (1) GB1110638A (en)
NL (1) NL6700243A (en)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248259A (en) * 1977-05-16 1981-02-03 Packard Instrument Company, Inc. Fluid flow control device
US4473739A (en) * 1980-12-18 1984-09-25 Helmholtz-Institut Fur Biomedizinische Technik Process and apparatus for warming of suspensions or solutions frozen in a flat plastic bag
US4782212A (en) * 1986-11-17 1988-11-01 Bakke Allan P Electric blood warmer utilizing a metallic ribbon-flow cartridge
US4847470A (en) * 1987-12-14 1989-07-11 Bakke Allan P Electric blood warmer utilizing metallic ribbon flow cartridge and low thermal mass heating units
WO1992017040A1 (en) * 1991-03-15 1992-10-01 In-Touch Products Co. Parenteral fluid warmer cassette, system and methods
FR2678512A1 (en) * 1991-07-03 1993-01-08 Novacell INTERNALIZING MACHINE.
US5181382A (en) * 1991-08-02 1993-01-26 Middlebrook Thomas F Heating/cooling or warming stage assembly with coverslip chamber assembly and perfusion fluid preheater/cooler assembly
US5381510A (en) * 1991-03-15 1995-01-10 In-Touch Products Co. In-line fluid heating apparatus with gradation of heat energy from inlet to outlet
EP0653215A1 (en) * 1993-07-12 1995-05-17 Otsuka Pharmaceutical Factory, Inc. Cooler for blood plasma cooling bags
US5564276A (en) * 1995-02-24 1996-10-15 United Defense, L.P. Micro-climate conditioning unit
US5584183A (en) * 1994-02-18 1996-12-17 Solid State Cooling Systems Thermoelectric heat exchanger
US5613364A (en) * 1995-10-06 1997-03-25 Pou, Inc. Compact replaceable temperature control module
WO1997034647A1 (en) * 1996-03-18 1997-09-25 Medtronic, Inc. Blood oxygenator with waterless heat exchanger
US5846224A (en) * 1996-10-01 1998-12-08 Baxter International Inc. Container for use with blood warming apparatus
US6047108A (en) * 1996-10-01 2000-04-04 Baxter International Inc. Blood warming apparatus
US6175688B1 (en) 1998-07-10 2001-01-16 Belmont Instrument Corporation Wearable intravenous fluid heater
US6755026B2 (en) * 2002-10-24 2004-06-29 Tech Medical Devices Inc. Thermoelectric system to directly regulate the temperature of intravenous solutions and bodily fluids
ES2264347A1 (en) * 2004-10-04 2006-12-16 Calor Hospitalario, S.L. Temperature regulating device for physiological fluid has thermal energy receiving unit that is disposed abutting contact plate and is arranged in thermal energy generating unit
WO2007068767A1 (en) * 2005-12-15 2007-06-21 Laboratorios CAIR España, S.L. Device for adjusting the temperature of a physiological fluid
US20080156476A1 (en) * 2005-03-17 2008-07-03 Smisson-Cartledge Biomedical Llc Heat Exchange System For A Pump Device
US20100030137A1 (en) * 2005-02-14 2010-02-04 Optiscan Biomedical Corporation Apparatus and methods for analyzing body fluid samples
WO2012019693A1 (en) * 2010-07-20 2012-02-16 Fresenius Medical Care Deutschland Gmbh Arrangement for heating a medical fluid, medical functional device, medical treatment device, and methods
CN101547830B (en) * 2006-11-09 2013-02-13 空中客车德国运营有限责任公司 Cooling device for installation in an aircraft
US8828068B2 (en) 2007-07-17 2014-09-09 Cardiac Pacemakers, Inc. Systems and methods for local vasoactive response using temperature modulation
US9737672B2 (en) 2007-08-07 2017-08-22 Belmont Instrument Corporation Hyperthermia, system, method, and components
US20170276402A1 (en) * 2016-03-23 2017-09-28 Wwt Technischer Geraetebau Gmbh Modular Blood Warmer
US9863837B2 (en) 2013-12-18 2018-01-09 OptiScan Biomedical Coporation Systems and methods for detecting leaks
US10137257B2 (en) 2016-11-30 2018-11-27 Belmont Instrument, Llc Slack-time heating system for blood and fluid warming
US10475529B2 (en) 2011-07-19 2019-11-12 Optiscan Biomedical Corporation Method and apparatus for analyte measurements using calibration sets
US10485936B2 (en) 2016-11-30 2019-11-26 Belmont Instrument, Llc Rapid infuser with advantageous flow path for blood and fluid warming
US10507292B2 (en) 2016-11-30 2019-12-17 Belmont Instrument, Llc Rapid infuser with vacuum release valve
US11000407B2 (en) 2007-08-07 2021-05-11 Belmont Instrument, Llc Hyperthermia, system, method, and components
US11077020B2 (en) 2013-05-07 2021-08-03 Biosafe S.A. Fluid processing based on inflatable bags, mixing system, and method of use thereof

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808473C2 (en) * 1978-02-28 1982-12-30 Hellige Gmbh, 7800 Freiburg Medical diagnostic device for determining bleeding time and bleeding behavior
FR2505294A1 (en) * 1981-05-11 1982-11-12 Extracorporeal Med Spec APPARATUS FOR HEATING OR COOLING FLUIDS AND CONTAINER FOR USE IN THIS APPARATUS
DE3639089A1 (en) * 1986-11-14 1988-05-26 Unitechnica Mobilkaelte Gmbh THERMOELECTRIC COOLING DEVICE
GB2252815B (en) * 1991-02-14 1995-10-04 Dyson John Newlyn Improvements in or relating to cooling apparatus
DE102006004756B4 (en) * 2005-07-29 2015-10-15 Herbert Wolf Peltier heat exchanger in modular design
ITMO20050243A1 (en) * 2005-09-23 2007-03-24 Rand Srl SYSTEM FOR THE MONITORING OF EXTRA-REPAIR CIRCULATION AND THE PERFUSION OF MEDICAL FLOWS DURING CARDIOPOLMONARY BYPASS
CN113251692B (en) * 2021-07-13 2021-09-10 苏州维嘉科技股份有限公司 Semiconductor temperature control device and automatic optical detection equipment using same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US286219A (en) * 1883-10-09 Frederic b
US3006979A (en) * 1959-04-09 1961-10-31 Carrier Corp Heat exchanger for thermoelectric apparatus
US3008300A (en) * 1959-04-09 1961-11-14 Carrier Corp Thermoelectric apparatus for heating or cooling of fluids
US3137141A (en) * 1962-04-19 1964-06-16 Halsey W Taylor Company Thermoelectric water coolers
US3238944A (en) * 1962-10-08 1966-03-08 Max L Hirschhorn Temperature controlling device for living organs
US3293868A (en) * 1965-02-16 1966-12-27 Medical Electroscience Inc Fluid cooling apparatus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US286219A (en) * 1883-10-09 Frederic b
US3006979A (en) * 1959-04-09 1961-10-31 Carrier Corp Heat exchanger for thermoelectric apparatus
US3008300A (en) * 1959-04-09 1961-11-14 Carrier Corp Thermoelectric apparatus for heating or cooling of fluids
US3137141A (en) * 1962-04-19 1964-06-16 Halsey W Taylor Company Thermoelectric water coolers
US3238944A (en) * 1962-10-08 1966-03-08 Max L Hirschhorn Temperature controlling device for living organs
US3293868A (en) * 1965-02-16 1966-12-27 Medical Electroscience Inc Fluid cooling apparatus

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248259A (en) * 1977-05-16 1981-02-03 Packard Instrument Company, Inc. Fluid flow control device
US4473739A (en) * 1980-12-18 1984-09-25 Helmholtz-Institut Fur Biomedizinische Technik Process and apparatus for warming of suspensions or solutions frozen in a flat plastic bag
US4782212A (en) * 1986-11-17 1988-11-01 Bakke Allan P Electric blood warmer utilizing a metallic ribbon-flow cartridge
US4847470A (en) * 1987-12-14 1989-07-11 Bakke Allan P Electric blood warmer utilizing metallic ribbon flow cartridge and low thermal mass heating units
US5381510A (en) * 1991-03-15 1995-01-10 In-Touch Products Co. In-line fluid heating apparatus with gradation of heat energy from inlet to outlet
US5245693A (en) * 1991-03-15 1993-09-14 In-Touch Products Co. Parenteral fluid warmer apparatus and disposable cassette utilizing thin, flexible heat-exchange membrane
WO1992017040A1 (en) * 1991-03-15 1992-10-01 In-Touch Products Co. Parenteral fluid warmer cassette, system and methods
FR2678512A1 (en) * 1991-07-03 1993-01-08 Novacell INTERNALIZING MACHINE.
WO1993000940A1 (en) * 1991-07-03 1993-01-21 Novacell Apparatus for delivering drugs into red blood corpuscles
US5589389A (en) * 1991-07-03 1996-12-31 Fondation Nationale De Transfusion Sanguine Apparatus for causing medicinal products to penetrate into red blood cells
US5181382A (en) * 1991-08-02 1993-01-26 Middlebrook Thomas F Heating/cooling or warming stage assembly with coverslip chamber assembly and perfusion fluid preheater/cooler assembly
EP0653215A1 (en) * 1993-07-12 1995-05-17 Otsuka Pharmaceutical Factory, Inc. Cooler for blood plasma cooling bags
EP0653215A4 (en) * 1993-07-12 1998-04-22 Otsuka Pharma Co Ltd Cooler for blood plasma cooling bags.
US5584183A (en) * 1994-02-18 1996-12-17 Solid State Cooling Systems Thermoelectric heat exchanger
US5564276A (en) * 1995-02-24 1996-10-15 United Defense, L.P. Micro-climate conditioning unit
US5613364A (en) * 1995-10-06 1997-03-25 Pou, Inc. Compact replaceable temperature control module
WO1998043026A1 (en) * 1995-10-06 1998-10-01 Pou, Inc. Compact replaceable temperature control module
WO1997034647A1 (en) * 1996-03-18 1997-09-25 Medtronic, Inc. Blood oxygenator with waterless heat exchanger
US6045752A (en) * 1996-03-18 2000-04-04 Medtronic, Inc. Blood oxygenator with waterless heat exchanger
US5846224A (en) * 1996-10-01 1998-12-08 Baxter International Inc. Container for use with blood warming apparatus
US6047108A (en) * 1996-10-01 2000-04-04 Baxter International Inc. Blood warming apparatus
US6175688B1 (en) 1998-07-10 2001-01-16 Belmont Instrument Corporation Wearable intravenous fluid heater
US6236809B1 (en) 1998-07-10 2001-05-22 Belmont Instrument Corporation Wearable intravenous fluid heater
US6480257B2 (en) 1998-07-10 2002-11-12 Belmont Instrument Corporation Heat exchanger useable in wearable fluid heater
US6755026B2 (en) * 2002-10-24 2004-06-29 Tech Medical Devices Inc. Thermoelectric system to directly regulate the temperature of intravenous solutions and bodily fluids
ES2264347A1 (en) * 2004-10-04 2006-12-16 Calor Hospitalario, S.L. Temperature regulating device for physiological fluid has thermal energy receiving unit that is disposed abutting contact plate and is arranged in thermal energy generating unit
US20100030137A1 (en) * 2005-02-14 2010-02-04 Optiscan Biomedical Corporation Apparatus and methods for analyzing body fluid samples
US20080156476A1 (en) * 2005-03-17 2008-07-03 Smisson-Cartledge Biomedical Llc Heat Exchange System For A Pump Device
US7975491B2 (en) * 2005-03-17 2011-07-12 Smisson-Cartledge Biomedical Llc Heat exchange system for a pump device
WO2007068767A1 (en) * 2005-12-15 2007-06-21 Laboratorios CAIR España, S.L. Device for adjusting the temperature of a physiological fluid
US20090056344A1 (en) * 2005-12-15 2009-03-05 Jaime Arbos Poch Device for adjusting the temperature of a physiological fluid
US7841189B2 (en) 2005-12-15 2010-11-30 Laboratorios Cair Espana, S.L. Device for adjusting the temperature of a physiological fluid
CN101547830B (en) * 2006-11-09 2013-02-13 空中客车德国运营有限责任公司 Cooling device for installation in an aircraft
US8828068B2 (en) 2007-07-17 2014-09-09 Cardiac Pacemakers, Inc. Systems and methods for local vasoactive response using temperature modulation
US9737672B2 (en) 2007-08-07 2017-08-22 Belmont Instrument Corporation Hyperthermia, system, method, and components
US11000407B2 (en) 2007-08-07 2021-05-11 Belmont Instrument, Llc Hyperthermia, system, method, and components
US9285137B2 (en) 2010-07-20 2016-03-15 Fresenius Medical Care Deutschland Gmbh Arrangement for heating a medical fluid, medical functional device, medical treatment apparatus and method
WO2012019693A1 (en) * 2010-07-20 2012-02-16 Fresenius Medical Care Deutschland Gmbh Arrangement for heating a medical fluid, medical functional device, medical treatment device, and methods
US10475529B2 (en) 2011-07-19 2019-11-12 Optiscan Biomedical Corporation Method and apparatus for analyte measurements using calibration sets
US11077020B2 (en) 2013-05-07 2021-08-03 Biosafe S.A. Fluid processing based on inflatable bags, mixing system, and method of use thereof
US11918541B2 (en) 2013-05-07 2024-03-05 Biosafe S.A. Fluid processing based on inflatable bags, mixing system, and method of use thereof
US9863837B2 (en) 2013-12-18 2018-01-09 OptiScan Biomedical Coporation Systems and methods for detecting leaks
US20170276402A1 (en) * 2016-03-23 2017-09-28 Wwt Technischer Geraetebau Gmbh Modular Blood Warmer
US10921021B2 (en) * 2016-03-23 2021-02-16 Wwt Technischer Geraetebau Gmbh Modular blood warmer
US10137257B2 (en) 2016-11-30 2018-11-27 Belmont Instrument, Llc Slack-time heating system for blood and fluid warming
US10485936B2 (en) 2016-11-30 2019-11-26 Belmont Instrument, Llc Rapid infuser with advantageous flow path for blood and fluid warming
US10507292B2 (en) 2016-11-30 2019-12-17 Belmont Instrument, Llc Rapid infuser with vacuum release valve
US11872382B2 (en) 2016-11-30 2024-01-16 Belmont Instrument, Llc Rapid infuser with advantageous flow path for blood and fluid warming, and associated components, systems, and methods

Also Published As

Publication number Publication date
CH460064A (en) 1968-07-31
DE1501134B2 (en) 1976-08-12
GB1110638A (en) 1968-04-24
DE1501134A1 (en) 1969-10-23
FR1509763A (en) 1968-01-12
BE693048A (en) 1967-07-03
NL6700243A (en) 1967-08-03

Similar Documents

Publication Publication Date Title
US3399536A (en) Device for varying the blood temperature
US20210113364A1 (en) Heat exchange system for patient temperature control with multiple coolant chambers for multiple heat exchange modalities
ES2030412T3 (en) THERMAL ELECTRIC REFRIGERATOR.
ES2046813T3 (en) DEVICE FOR THE MANUFACTURE OF TRANSPARENT ICE CUBES.
US2870610A (en) Thermoelectric heat pumps
US2552635A (en) Heat exchanger for cooling liquids
US3266258A (en) Method of increasing a vapour compressing refrigerating machine cooling effect
CN207303640U (en) A kind of water cooling system of laser based on semiconductor heat-dissipating piece
JPH06335954A (en) Heating and cooling device of screw cylinder
ATE118270T1 (en) CHILLER WITH PERFORMANCE ADJUSTMENT.
US3242680A (en) Device for suppressing the thermal backflow from a heat-exchanger to the cooling space of a cooling device equipped especially with a thermoelectric cooling element
RU2801245C1 (en) Device for liquid cooling of thermoelectric generator
JPH0566096A (en) Heat dissipation section of heat pipe type radiator
KR102358931B1 (en) Heat exchanger
JPH1062033A (en) Absorption type cold and hot water machine
JPH0830631B2 (en) Cold temperature switching absorption refrigerator
JP2580335B2 (en) Cooling system
JPS6038261Y2 (en) Cooling system
SU454398A2 (en) Thermoelectric heat pump
JP2699533B2 (en) Refrigeration equipment
JPS6285451A (en) Heat transfer apparatus
KR19990024929A (en) Cooling device using thermoelectric cooling module
JP2731083B2 (en) Heat storage device
RU2072488C1 (en) Air cooler
KR0129340Y1 (en) Cooling system of the engine and transmission cooler