US3410645A - Concave diaphragm applicator - Google Patents

Concave diaphragm applicator Download PDF

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Publication number
US3410645A
US3410645A US636800A US63680067A US3410645A US 3410645 A US3410645 A US 3410645A US 636800 A US636800 A US 636800A US 63680067 A US63680067 A US 63680067A US 3410645 A US3410645 A US 3410645A
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pad
diaphragm
applicator
projecting portion
flange
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US636800A
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Schwartzman Gilbert
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    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47LDOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L23/00Cleaning footwear
    • A47L23/04Hand implements for shoe-cleaning, with or without applicators for shoe polish
    • A47L23/05Hand implements for shoe-cleaning, with or without applicators for shoe polish with applicators for shoe polish
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00Closures with filling and discharging, or with discharging, devices
    • B65D47/42Closures with filling and discharging, or with discharging, devices with pads or like contents-applying means
    • B65D47/44Closures with filling and discharging, or with discharging, devices with pads or like contents-applying means combined with slits opening when container is deformed or when pad is pressed against surface to which contents are to be applied

Definitions

  • CONCAVE DIAPHRAGM APPLICATOR Filed May 8, 1967 I N VEN TOR. 4 166.97 J/mwerz/ww 3M JMM United States Patent 3,410,645 CONCAVE DIAPHRAGM APPLICATOR Gilbert Schwartzman, 20 Wilmot Circle, Scarsdale, N.Y. 10583 Filed May 8, 1967, Ser. No. 636,800 7 Claims. (Cl. 401-135) ABSTRACT OF THE DISCLOSURE
  • An applicator for applying shoe polish, medications, cosmetics, and the like comprising a body having a projecting portion attached to a container. A relatively thick flange at the top of the projecting portion has a substantially flat surface to which a sponge-like pad is bonded.
  • a diaphragm Integral with the flange and the projecting portion is a diaphragm having normally closed slits therein.
  • a stud is integral with the diaphragm and extends into the pad and upon depression of the pad and the stud the diaphragm will flex inwardly to open the diaphragm for permitting and directing fluid flow against the pad for optimum application of the fluid on the surface to be covered.
  • This invention relates to an applicator applying on any suitable surface various types of fluids such as shoe polish, pigments, cosmetics, medications or the like.
  • the concept of the invention resides in the utilization of a diaphragm integral with a relatively thick flange which supports a sponge-like padded bonded to the flange and spaced from the diaphragm.
  • the diaphragm has slits therein so that upon actuation of a stud integral with the diaphragm the slits will open and the diaphragm will direct fluid against the under surface of the pad for optimum application of the fluid.
  • a further object of the invention resides in the provision of a device for applying shoe polish or like fluid which is intially sealed so as to provide for long shelf life and reduced evaporation.
  • a further object of the invention resides in the provision of an applicator made out of two simple parts of readily available materials, which has a novel streamlined andhighly attractive appearance, yet which is substantially foolproof and eifective in operation and capable of applying fluids into even tight corners and crevices such as often occur on shoes and like surfaces.
  • Still further objects and features of this invention reside in the provision of an applicator which is simple in construction, strong and durable, capable of being manufactured at an extremely low cost, yet which is highly effective in use.
  • FIG. 1 is a longitudinal sectional view of the appplicator shown mounted on a container and in the normally closed position;
  • FIG. 2 is a sectional detail view taken along the plane of line 22 in FIG. 1 showing the device in the normally closed position;
  • FIG. 3 is a view showing the device in use with the diaphragm in the open position
  • FIG. 4 is a sectional detail view looking in the direction of line 44 in FIG. 3 showing the diaphragm with the slits in their open position;
  • FIG. 5 is a perspective view of the applicator.
  • FIG. 6 is a top plane view of a modified form of the applicator.
  • reference numeral 10 is used to generally designate an applicator constructed in accordance with the concepts of the present invention, and which is designed to be used in combination with a container 12 having a neck 14 provided with a lip 16.
  • the applicator includes a body generally indicated at 1'8 and having a projecting portion 20 provided with a groove 22 therein for receiving the lip 16 which is snap fitted therein for holding the body 18 to the container 12.
  • threaded means in lieu of the snap-fitting arrangement or to. fit the projecting portion 20 within the neck 14. Nevertheless, the snap fitting arrangement of the lip 16 and the groove 22 provides for better support for a pad 24 mounted at the top of the body 18.
  • the body 18 further includes a flange 26 which is relatively thick and extends outwardly to provide a substantially large and substantially flat supporting surface 28 to which the pad 24 is affixed by heating sealing or adhesive bonding.
  • a diaphragm 30 Integrally formed with the flange 26 and the projecting portion 20 is a diaphragm 30 which extends transverse of the projecting portion 20 forming a web across the projecting portion.
  • the diaphragm 30 is normally concave downwardly and has four slots 32 therein each extending normal to a radius of the Web 30 and offset degrees from each other. Rising from the center of the web is a stud 34 which extends more than half way up the pad 24 and sits in a central hole or bore 3-6 formed in the pad 24.
  • the slots 32 are formed by utilizing hot knives which cut the slots but when withdrawn permit for the synthetic plastic matter from which the body 18 is formed to seal the slots 32 in a positive manner preventing any fluid flow until the seals which are frangible are broken.
  • depression of the stud 34 which would come from normal pressure of the applicator on a suitable surface as is shown in FIG. 3, will cause the diaphragm 30 to flex inwardly opening the slits as shown in FIG. 4 to permit flui-d from the container 12 to flow outwardly in the direction of arrows 38 and through the sponge as indicated by arrows 40.
  • the removal of pressure on the sponge-like pad 24 will cause the diaphragm 30 to flex inwardly and pump the remaining fluid in the enlarged reservoir 42 onto the undersurface of the pad 24 so that light pressure insuificient to flex the diaphragmv may then be used to coat with the pad 24 of the applicator the surface being treated.
  • the reservoir 42 is defined by the undersurface of the pad 24 and the web 30.
  • FIG. 6 there is shown a modified form of the invention in which the flange is generally indicated by reference numeral 60 and is of rectangular shape, while the pad 62 is likewise of rectangular shape otherwise the parts are similar.
  • An applicator comprising a body having a projecting portion for attachment to a container, an outwardly extending relatively thick flange at the top of said projecting portion having a substantially flat upper surface, a relatively thin resilient flexible diaphragm integral with said flange and said projecting portion and extending transverse to said projecting portion forming a web across said projecting portion, a stud integrally formed with said diaphragm rising upwardly therefrom, said diaphragm being concave downwardly and having spaced normally closed slits therein, and a sponge-like pad bonded to said flange and spaced from said diaphragm forming a reservoir between said pad and said diaphragm, said pad having means therein for receiving said stud so that pressure on said pad will cause said diaphragm to flex and open said slits.
  • An applicator according to claim 1 including frangible sealing means initially integrally sealing said slits until first depression of said pad.
  • An applicator according to claim 1 including a container having a lip, said projecting portion having a groove in the inner sunface thereof, said lip being snap fitted in said groove.

Description

Nov. 12, 1968 G. SCHWARTZMAN 3,410,645
CONCAVE DIAPHRAGM APPLICATOR Filed May 8, 1967 I N VEN TOR. 4 166.97 J/mwerz/ww 3M JMM United States Patent 3,410,645 CONCAVE DIAPHRAGM APPLICATOR Gilbert Schwartzman, 20 Wilmot Circle, Scarsdale, N.Y. 10583 Filed May 8, 1967, Ser. No. 636,800 7 Claims. (Cl. 401-135) ABSTRACT OF THE DISCLOSURE An applicator for applying shoe polish, medications, cosmetics, and the like comprising a body having a projecting portion attached to a container. A relatively thick flange at the top of the projecting portion has a substantially flat surface to which a sponge-like pad is bonded. Integral with the flange and the projecting portion is a diaphragm having normally closed slits therein. A stud is integral with the diaphragm and extends into the pad and upon depression of the pad and the stud the diaphragm will flex inwardly to open the diaphragm for permitting and directing fluid flow against the pad for optimum application of the fluid on the surface to be covered.
This invention relates to an applicator applying on any suitable surface various types of fluids such as shoe polish, pigments, cosmetics, medications or the like. Briefly, the concept of the invention resides in the utilization of a diaphragm integral with a relatively thick flange which supports a sponge-like padded bonded to the flange and spaced from the diaphragm. The diaphragm has slits therein so that upon actuation of a stud integral with the diaphragm the slits will open and the diaphragm will direct fluid against the under surface of the pad for optimum application of the fluid.
A further object of the invention resides in the provision of a device for applying shoe polish or like fluid which is intially sealed so as to provide for long shelf life and reduced evaporation.
A further object of the invention resides in the provision of an applicator made out of two simple parts of readily available materials, which has a novel streamlined andhighly attractive appearance, yet which is substantially foolproof and eifective in operation and capable of applying fluids into even tight corners and crevices such as often occur on shoes and like surfaces.
Still further objects and features of this invention reside in the provision of an applicator which is simple in construction, strong and durable, capable of being manufactured at an extremely low cost, yet which is highly effective in use.
These, together with the various ancillary objects and features of the invention, which will become apparent as the following description proceeds, are attained by this concave diaphragm applicator, a preferred embodiment of which is shown in the accompanying drawing, by way of example only, wherein:
FIG. 1 is a longitudinal sectional view of the appplicator shown mounted on a container and in the normally closed position;
FIG. 2 is a sectional detail view taken along the plane of line 22 in FIG. 1 showing the device in the normally closed position;
FIG. 3 is a view showing the device in use with the diaphragm in the open position;
FIG. 4 is a sectional detail view looking in the direction of line 44 in FIG. 3 showing the diaphragm with the slits in their open position;
FIG. 5 is a perspective view of the applicator, and,
FIG. 6 is a top plane view of a modified form of the applicator.
3,410,645 Patented Nov. 12, 1968 ice With continuing reference to the accompanying drawing wherein like reference numerals designate similar parts throughout the various views, reference numeral 10 is used to generally designate an applicator constructed in accordance with the concepts of the present invention, and which is designed to be used in combination with a container 12 having a neck 14 provided with a lip 16. The applicator includes a body generally indicated at 1'8 and having a projecting portion 20 provided with a groove 22 therein for receiving the lip 16 which is snap fitted therein for holding the body 18 to the container 12. It is within the concepts of the present invention to use threaded means in lieu of the snap-fitting arrangement or to. fit the projecting portion 20 within the neck 14. Nevertheless, the snap fitting arrangement of the lip 16 and the groove 22 provides for better support for a pad 24 mounted at the top of the body 18.
The body 18 further includes a flange 26 which is relatively thick and extends outwardly to provide a substantially large and substantially flat supporting surface 28 to which the pad 24 is affixed by heating sealing or adhesive bonding. Integrally formed with the flange 26 and the projecting portion 20 is a diaphragm 30 which extends transverse of the projecting portion 20 forming a web across the projecting portion. The diaphragm 30 is normally concave downwardly and has four slots 32 therein each extending normal to a radius of the Web 30 and offset degrees from each other. Rising from the center of the web is a stud 34 which extends more than half way up the pad 24 and sits in a central hole or bore 3-6 formed in the pad 24. The slots 32 are formed by utilizing hot knives which cut the slots but when withdrawn permit for the synthetic plastic matter from which the body 18 is formed to seal the slots 32 in a positive manner preventing any fluid flow until the seals which are frangible are broken.
Depression of the stud 34 which would come from normal pressure of the applicator on a suitable surface as is shown in FIG. 3, will cause the diaphragm 30 to flex inwardly opening the slits as shown in FIG. 4 to permit flui-d from the container 12 to flow outwardly in the direction of arrows 38 and through the sponge as indicated by arrows 40. The removal of pressure on the sponge-like pad 24 will cause the diaphragm 30 to flex inwardly and pump the remaining fluid in the enlarged reservoir 42 onto the undersurface of the pad 24 so that light pressure insuificient to flex the diaphragmv may then be used to coat with the pad 24 of the applicator the surface being treated. The reservoir 42 is defined by the undersurface of the pad 24 and the web 30.
In FIG. 6 there is shown a modified form of the invention in which the flange is generally indicated by reference numeral 60 and is of rectangular shape, while the pad 62 is likewise of rectangular shape otherwise the parts are similar.
A latitude of modification, substitution and change is intended in the foregoing disclosure and in some instances, some features of the. invention will be employed without a corresponding use of other features. Accordingly, it is appropriate that the appended claims be construed broadly and in a manner consistent with the spirit and scope of the invention herein.
I claim:
1. An applicator comprising a body having a projecting portion for attachment to a container, an outwardly extending relatively thick flange at the top of said projecting portion having a substantially flat upper surface, a relatively thin resilient flexible diaphragm integral with said flange and said projecting portion and extending transverse to said projecting portion forming a web across said projecting portion, a stud integrally formed with said diaphragm rising upwardly therefrom, said diaphragm being concave downwardly and having spaced normally closed slits therein, and a sponge-like pad bonded to said flange and spaced from said diaphragm forming a reservoir between said pad and said diaphragm, said pad having means therein for receiving said stud so that pressure on said pad will cause said diaphragm to flex and open said slits.
2. An applicator according to claim 1, including frangible sealing means initially integrally sealing said slits until first depression of said pad.
3. An applicator according to claim 1, wherein said pad is formed of foamed polyurethane.
4. An applicator according to claim 1, including a container having a lip, said projecting portion having a groove in the inner sunface thereof, said lip being snap fitted in said groove.
5. An applicator according to claim 1, wherein said stud extends more than half the thickness of said pad, said pad having a hole therein receiving said stud.
6. An applicator according to claim 1, wherein said flange and said pad are circular in shape.
7. An applicator according to claim 1, wherein said flange and said pad are rectangular in shape.
References Cited UNITED STATES PATENTS 1,185,760 '6/1916 Berry 15581 1,188,971 6/1916 Miller 1558l 1,959,774 5/1939 Walsh 15--582 2,075,249 3/1937 Wilson 15-579 XR 2,911,664 11/1959 Zecchini 15561 XR 2,913,748 11/1959 Felter 15582 3,147,512 9/1964 Gleason 15582 XR 3,271,810 9/1966 Rafie 15539 3,276,067 10/1966 Boyle et el. 15582 3,296,649 1/1967 Schwartzman 15--566 2,284,207 5/1942 Hawkins 401-145 3,264,676 8/1966 Schwartzrnan 401-206 XR 3,337,900 8/ 1967 Schwartzrnan 401-206 CHARLES A. WILLMUTH, Primary Examiner.
ROBERT I. SMITH, Assistant Examiner.
US636800A 1967-05-08 1967-05-08 Concave diaphragm applicator Expired - Lifetime US3410645A (en)

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Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3009587A1 (en) * 1980-03-13 1981-09-17 Eau de Cologne- & Parfümerie-Fabrik Glockengasse No. 4711 gegenüber der Pferdepost von Ferd. Mülhens, 5000 Köln Applicator for body care preparations e.g. shower gels - has sponge or similar linked by distributor to fluid supply container
US4555194A (en) * 1983-05-26 1985-11-26 Reckitt & Colman Products Limited Applicator with resilient valve
US4620648A (en) * 1982-07-06 1986-11-04 Dab-O-Matic Corp. Pressure-responsive valve
US4693623A (en) * 1984-03-02 1987-09-15 Dab-O-Matic Corp. Pressure-responsive valve for an applicator
EP0271044A2 (en) * 1986-12-08 1988-06-15 S.C. Johnson & Son, Inc. Fluid applicator for shoes and the like
US4762433A (en) * 1987-07-02 1988-08-09 S. C. Johnson & Son, Inc. Fluid applicator for shoes and the like
US4993859A (en) * 1989-05-24 1991-02-19 Truly Magic Products, Inc. Liquid applicator valve structure
NL1011711C2 (en) * 1999-03-31 2000-10-03 Sara Lee De Nv Device for working a surface, in particular of a leather surface, such as that of leather shoes.
US6357949B1 (en) * 1999-10-08 2002-03-19 Gil Schwartzman Article containing an integral liquid-release valve and method for manufacturing a pressure responsive valve for fluid dispensing containers
US6485212B1 (en) * 2000-11-21 2002-11-26 Gregory Jay Bomgaars Device for applying liquid to vehicle tires
US20040124117A1 (en) * 2002-07-17 2004-07-01 L'oreal Receptacle having a neck provided with two portions of different diameters
US20060072962A1 (en) * 2004-10-04 2006-04-06 3M Innovative Properties Company Surgical prep solution applicator
US20080025917A1 (en) * 2006-04-10 2008-01-31 Malcolm Whitman Methods for modulating formation and progression of cellulite
US20090123389A1 (en) * 2007-08-15 2009-05-14 Malcolm Whitman Methods for modulating Th17 cell development in the treatment and prevention of cellulite
US20100094249A1 (en) * 2008-10-09 2010-04-15 Ty Caswell Wound treatment apparatus and methods
US20110212100A1 (en) * 2007-08-15 2011-09-01 Tracy Keller Methods for modulating development and expansion of il-17 expressing cells
US8613286B2 (en) 2011-09-19 2013-12-24 Melvin R. Kennedy Method and device for dispensing a material into a representation on a surface
US9284297B2 (en) 2008-08-11 2016-03-15 President And Fellows Of Harvard College Halofuginone analogs for inhibition of tRNA synthetases and uses thereof
WO2016077818A1 (en) 2014-11-14 2016-05-19 Melinta Therapeutics, Inc. Method for treating, preventing, or reducing the risk of skin infection
WO2017200979A1 (en) 2016-05-17 2017-11-23 Melinta Therapeutics, Inc. Topical formulations of biaryl heterocyclic compounds and methods of use thereof
US11708353B2 (en) 2018-06-08 2023-07-25 The General Hospital Corporation Inhibitors of prolyl-tRNA-synthetase

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1185760A (en) * 1915-08-04 1916-06-06 Ben E Berry Dauber.
US1188971A (en) * 1915-09-22 1916-06-27 Brevard D Miller Fountain-brush.
US1959774A (en) * 1932-03-10 1934-05-22 William J Walsh Adhesive applicator
US2075249A (en) * 1935-11-23 1937-03-30 Ralph W Wilson Closure for containers
US2284207A (en) * 1941-12-01 1942-05-26 Hawkins John Smith Shaving brush
US2911664A (en) * 1957-01-10 1959-11-10 Zecchini Pierre Yves Liquid-product dispenser for the direct application on surfaces
US2913748A (en) * 1957-11-12 1959-11-24 Richard H Felter Liquid or cream applicator tops for containers
US3147512A (en) * 1961-02-13 1964-09-08 American Home Prod Shoe polish dispenser
US3264676A (en) * 1964-04-02 1966-08-09 Schwartzman Gilbert Spin welded package
US3271810A (en) * 1963-07-04 1966-09-13 Reckitt & Colman Overseas Dispensers for liquid, powder or the like materials
US3276067A (en) * 1962-08-15 1966-10-04 Union Carbide Corp Applicator for dispensing liquids
US3296649A (en) * 1964-10-20 1967-01-10 Schwartzman Gilbert Sealed applicator
US3337900A (en) * 1965-02-18 1967-08-29 Schwartzman Gilbert Applicator having diaphragm mounted valve structure

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1185760A (en) * 1915-08-04 1916-06-06 Ben E Berry Dauber.
US1188971A (en) * 1915-09-22 1916-06-27 Brevard D Miller Fountain-brush.
US1959774A (en) * 1932-03-10 1934-05-22 William J Walsh Adhesive applicator
US2075249A (en) * 1935-11-23 1937-03-30 Ralph W Wilson Closure for containers
US2284207A (en) * 1941-12-01 1942-05-26 Hawkins John Smith Shaving brush
US2911664A (en) * 1957-01-10 1959-11-10 Zecchini Pierre Yves Liquid-product dispenser for the direct application on surfaces
US2913748A (en) * 1957-11-12 1959-11-24 Richard H Felter Liquid or cream applicator tops for containers
US3147512A (en) * 1961-02-13 1964-09-08 American Home Prod Shoe polish dispenser
US3276067A (en) * 1962-08-15 1966-10-04 Union Carbide Corp Applicator for dispensing liquids
US3271810A (en) * 1963-07-04 1966-09-13 Reckitt & Colman Overseas Dispensers for liquid, powder or the like materials
US3264676A (en) * 1964-04-02 1966-08-09 Schwartzman Gilbert Spin welded package
US3296649A (en) * 1964-10-20 1967-01-10 Schwartzman Gilbert Sealed applicator
US3337900A (en) * 1965-02-18 1967-08-29 Schwartzman Gilbert Applicator having diaphragm mounted valve structure

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3009587A1 (en) * 1980-03-13 1981-09-17 Eau de Cologne- & Parfümerie-Fabrik Glockengasse No. 4711 gegenüber der Pferdepost von Ferd. Mülhens, 5000 Köln Applicator for body care preparations e.g. shower gels - has sponge or similar linked by distributor to fluid supply container
US4620648A (en) * 1982-07-06 1986-11-04 Dab-O-Matic Corp. Pressure-responsive valve
US4555194A (en) * 1983-05-26 1985-11-26 Reckitt & Colman Products Limited Applicator with resilient valve
US4693623A (en) * 1984-03-02 1987-09-15 Dab-O-Matic Corp. Pressure-responsive valve for an applicator
EP0271044A2 (en) * 1986-12-08 1988-06-15 S.C. Johnson & Son, Inc. Fluid applicator for shoes and the like
EP0271044A3 (en) * 1986-12-08 1988-09-07 S.C. Johnson & Son, Inc. Fluid applicator for shoes and the like
US4762433A (en) * 1987-07-02 1988-08-09 S. C. Johnson & Son, Inc. Fluid applicator for shoes and the like
US4993859A (en) * 1989-05-24 1991-02-19 Truly Magic Products, Inc. Liquid applicator valve structure
NL1011711C2 (en) * 1999-03-31 2000-10-03 Sara Lee De Nv Device for working a surface, in particular of a leather surface, such as that of leather shoes.
WO2000057764A2 (en) * 1999-03-31 2000-10-05 Sara Lee/De N.V. Device for treating a leather surface with a substance and substance for treating said surface
WO2000057764A3 (en) * 1999-03-31 2003-04-17 Sara Lee De Nv Device for treating a leather surface with a substance and substance for treating said surface
US7441975B1 (en) 1999-03-31 2008-10-28 Sara Lee / De N.V. Device for treating a surface, in particular a leather surface, such as that of leather shoes
US6357949B1 (en) * 1999-10-08 2002-03-19 Gil Schwartzman Article containing an integral liquid-release valve and method for manufacturing a pressure responsive valve for fluid dispensing containers
US6485212B1 (en) * 2000-11-21 2002-11-26 Gregory Jay Bomgaars Device for applying liquid to vehicle tires
US20040124117A1 (en) * 2002-07-17 2004-07-01 L'oreal Receptacle having a neck provided with two portions of different diameters
US7798154B2 (en) * 2002-07-17 2010-09-21 L'oreal Receptacle having a neck provided with two portions of different diameters
US20060072962A1 (en) * 2004-10-04 2006-04-06 3M Innovative Properties Company Surgical prep solution applicator
US7540681B2 (en) * 2004-10-04 2009-06-02 3M Innovative Properties Company Surgical prep solution applicator
US20080025917A1 (en) * 2006-04-10 2008-01-31 Malcolm Whitman Methods for modulating formation and progression of cellulite
US20090123389A1 (en) * 2007-08-15 2009-05-14 Malcolm Whitman Methods for modulating Th17 cell development in the treatment and prevention of cellulite
US20110212100A1 (en) * 2007-08-15 2011-09-01 Tracy Keller Methods for modulating development and expansion of il-17 expressing cells
US9284297B2 (en) 2008-08-11 2016-03-15 President And Fellows Of Harvard College Halofuginone analogs for inhibition of tRNA synthetases and uses thereof
US20100094249A1 (en) * 2008-10-09 2010-04-15 Ty Caswell Wound treatment apparatus and methods
US8613286B2 (en) 2011-09-19 2013-12-24 Melvin R. Kennedy Method and device for dispensing a material into a representation on a surface
WO2016077818A1 (en) 2014-11-14 2016-05-19 Melinta Therapeutics, Inc. Method for treating, preventing, or reducing the risk of skin infection
US10471046B2 (en) 2014-11-14 2019-11-12 Melinta Subsidary Corp. Method for treating, preventing, or reducing the risk of skin infection
WO2017200979A1 (en) 2016-05-17 2017-11-23 Melinta Therapeutics, Inc. Topical formulations of biaryl heterocyclic compounds and methods of use thereof
US11708353B2 (en) 2018-06-08 2023-07-25 The General Hospital Corporation Inhibitors of prolyl-tRNA-synthetase

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