US3598122A - Bandage for administering drugs - Google Patents

Bandage for administering drugs Download PDF

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Publication number
US3598122A
US3598122A US812116A US3598122DA US3598122A US 3598122 A US3598122 A US 3598122A US 812116 A US812116 A US 812116A US 3598122D A US3598122D A US 3598122DA US 3598122 A US3598122 A US 3598122A
Authority
US
United States
Prior art keywords
bandage
reservoir layer
release rate
systemically active
rate controlling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US812116A
Inventor
Alejandro Zaffaroni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of US3598122A publication Critical patent/US3598122A/en
Application granted granted Critical
Publication of US3598122B1 publication Critical patent/US3598122B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

Bandage for use in the continuous administration of systemically active drugs by absorption through the skin or oral mucosa comprising a backing member having on one surface thereof a reservoir containing a systemically active drug. The reservoir has a wall distant from the backing member and permeable to passage of the drug. A pressure-sensitive adhesive layer, also permeable to passage of the drug, is carried by the reservoir. The drug is in a form acceptable for absorption through the skin or the mucosa of the mouth.

Claims (15)

1. A medical bandage for use in the continuous administration to circulation of controlled quantities of systemically active drugs over a prolonged period of time by absorption through the external body skin or mucosa, said bandage comprising a sandwich including (1) a backing member; (2) a discrete, middle reservoir layer containing a systemically active drug, which reservoir layer is comprised of systemically active drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of drug from the said reservoir to the skin or mucosa at a controlled and predetermined rate over a prolonged period of time; and (3) a surface of a pressure-sensitive adhesive adapted for contact with the skin or mucosa of a patient.
2. The bandage as defined by claim 1, wherein the reservoir layer (2) is comprised of a walled container having an interior chamber containing the systemically active drug formulation.
3. The bandage as defined by claim 1, wherein the reservoir layer (2) is comprised of a matrix of the drug release rate controlling wall material, said matrix having the systemically active drug formulation distributed therethrough.
4. The bandage as defined by claim 1, wherein the systemically active drug formulation is soluble in the drug release rate controlling material.
5. The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is permeable to passage of the systemically active drug formulation.
6. The bandage as defined by claim 1, wherein the drug formulation comprises a pharmacologically acceptable solvent.
7. The bandages as defined by claim 1, further comprising a solubility membrane (4) interposed between said reservoir layer (2) and said surface of pressure-sensitive adhesive (3).
8. The bandage as defined by claim 1, wherein said drug release rate controlling material is silicone rubber.
9. The bandage as defined by claim 1, wherein said drug release rate controlling material is a hydrophilic polymer of an ester of an olefinic acid.
10. The bandage as defined by claim 1, wherein at least that portion of the wall member comprising the reservoir layer (2) which is adapted to be brought contiguous the skin as mucosa is formed from the drug release rate controlling material.
11. The bandage as defined by claim 1, wherein the wall member comprising the reservoir layer (2) consists of drug release rate controlling material.
12. The bandage as defined by claim 1, wherein the outer surface of the wall member comprising the reservoir layer (2) also defines the said backing member (1).
13. The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is adapted to provide a liquidtight adhesive seal between the skin or mucosa and the bandage.
14. The bandage as defined by claim 1, wherein the surface of a pressure-sensitive adhesive (3) is covered with a protective release coating (5).
15. The bandage as defined by claim 1, wherein the outer surface of the backing member (1) is coated with a low-adhesion backsize (6).
US812116A 1969-04-01 1969-04-01 Bandage for administering drugs Expired - Lifetime US3598122A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81211669A 1969-04-01 1969-04-01
ZA714095A ZA714095B (en) 1969-04-01 1971-06-22 Bandage for administering drugs

Publications (2)

Publication Number Publication Date
US3598122A true US3598122A (en) 1971-08-10
US3598122B1 US3598122B1 (en) 1982-11-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
US812116A Expired - Lifetime US3598122A (en) 1969-04-01 1969-04-01 Bandage for administering drugs

Country Status (2)

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US (1) US3598122A (en)
ZA (1) ZA714095B (en)

Cited By (439)

* Cited by examiner, † Cited by third party
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