US3748101A - Centrifuge fluid container - Google Patents

Centrifuge fluid container Download PDF

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Publication number
US3748101A
US3748101A US00221530A US3748101DA US3748101A US 3748101 A US3748101 A US 3748101A US 00221530 A US00221530 A US 00221530A US 3748101D A US3748101D A US 3748101DA US 3748101 A US3748101 A US 3748101A
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United States
Prior art keywords
container
bag
periphery
tube
fluid
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Expired - Lifetime
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US00221530A
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A Jones
G Judson
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Terumo BCT Inc
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International Business Machines Corp
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Assigned to COBE LABORATORIES, INC. reassignment COBE LABORATORIES, INC. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: INTERNATIONAL BUSINESS MACHINES CORPORATION, A CORP. OF NEW YORK
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q

Definitions

  • FIG. 2 A. L. JONES ETAL CENTRIFUGE FLUID CONTAINER Filed Jan. 28, 1972 FIG. 2
  • a fluid container particularly useful in a system for processing blood is generally annular or toroidal in shape, with a central hub portion which communicates with the annular portion via a plurality of radial channels, and is preferably formed from two circular pieces of plastic material, sealed at the periphery, and in centrally-located segments to provide the desired configuration.
  • a central hub provides one fluid entrance and exit.
  • a peripherally-located output tube, appropriately sealed, is located opposite a slitted flap, to provide means for suspending the container from a support and draining the container by gravity through the outlet tube.
  • a sampling tube may also be provided, connected to the periphery of the bag.
  • a copending patent application, Ser. No. 211,194 filed on Dec. 23, 1971 discloses and claims a blood processing system in which thawed frozen blood is washed to remove glycerol or other cryopreservative agents.
  • This system requires a blood container which is circular in shape and has a centrally-located fluid inlet/outlet tube.
  • the present invention provides an improved fluid container for use in the referenced blood processing system.
  • a specific object of the invention is to provide an improved fluid container for processing thawed blood including a centrifuging step.
  • a further object of the invention is to provide an improved blood container for centrifuging incorporating radial fluid channels to exclude the blood mixture from the low G force area near the center of rotation.
  • the fluid container provided by this invention is an annular or toroidal-shaped container when filled with fluid. It is preferably formed by sealing two identical circular pieces of suitable flexible elastic material, such as medical-grade polyvinylchloride, at the periphery thereof to provide an enclosed volume. A plurality of sector-shaped areas, centrally located, are formed by sealing the two sides of the bag together. This provides a central or hub portion which communicates with the annular outer portion by a plurality of radial channels. A fluid inlet/outlet tube is located on the axis of the bag, to permit entrance and exit of fluid via the radial channels. (The radial channels confine the major volume of the blood to the outer portions of the bag, where higher G forces are available, and centrifuging time is accordingly reduced.)
  • a sealed outlet tube is provided at the periphery of the bag, and a hanger opening is provided diametrically opposite the outlet tube, so that the bag can be suspended from a suitable support and drained by gravity via tubing attached to the bag by way of the outlet tube.
  • a sampling tube may also be provided, having one end connected to the bag at the periphery thereof.
  • FIG. 1 is a diagrammatic plan view of a fluid container comprising a preferred embodiment of the invention
  • the fluid container is circular in general shape as manifest in FIGS. 1 and 3.
  • Two circular pieces 3a and 3b of suitable dimensions, of material suited to the purpose, such as medical-grade polyvinylchloride, are sealed together at their periphery, as by application of suitable heat and pressure.
  • a plurality of sectorshaped areas 5 of the two sides 3a and 3b are further sealed together to be liquid tight. It is apparent that this configuration will then provide a plurality of radial channels 7 extending outwardly from the center of the bag.
  • a fluid inlet/ outlet hub 11 Located on the central axis of the bag is a fluid inlet/ outlet hub 11. Insertion of a suitable tubing connector provided with a rotating seal, not shown, permits fluid to be supplied to or withdrawn from the bag during centrifuging.
  • an outlet tube 15 can be provided at the periphery of the bag.
  • This tube can be of semi-rigid plastic material, entering the bag radially as shown, and appropriately sealed in place.
  • An inner cap 17 and an outer cap 19 are shown.
  • Inner cap 17 prevents exit of the bag contents during processing while cap 19 protects the sterility of the interior of the outlet tube.
  • the outer cap 19 would be removed, and the stabber or cannula of a suitable tubing set would be thrust into tube 15, the end of the cannula forcing off the cap 17 to permit outward flow of the bag contents.
  • outlet tube 15 Opposite the outlet tube 15, the rim of the bag 'is slit as shown at 21, to permit the bag to be suspended from a suitable support when draining through outlet tube 15.
  • a sampling tube 25 may also be provided, one end of which is attached to the periphery of the bag, and the other end of which is closed, as by heating sealing.
  • a portion of the bag contents may be expressed into the coupling tube, and then the tube may be cut off and sealed near its connection to the bag, so that the contents of the sampling tube can be used for tests.
  • the present invention provides an improved fluid container, particularly suited for centrifuging of blood, which is economi i cal to manufacture, maximizes exposure to G force, thereby reducing time of centrifugation, and is adapted to dispense the contained blood or other fluid in conventional manner.
  • a flexible collapsible blood processing container comprising,
  • a central hub portion having an axially-aligned inlet/ outlet tube connection, a plurality of radial channels integrally formed and extending radially from said hub portion to said outer portion,
  • a container as claimed in claim 1 in which said container is fomed from two circular pieces of material, sealed together at the periphery thereof, and sealed together at selected sector-shaped central portions to form said central hub portion and said channels.
  • a container as claimed in claim 1 in which a sampling tube is provided, having one end thereof sealed in theperiphery of said container and communicating with the interior of the container.

Abstract

A FLUID CONTAINER PARTICULARLY USEFUL IN A SYSTEM FOR PROCESSING BLOOD. THE CONTAINER IS GENERALLY ANNULAR OR TOROIDAL IN SHAPE, WITH A CENTRAL HUB PORTION WHICH COMMUNICATES WITH THE ANNULAR PORTION VIA A PLURALITY OF RADIAL CHANNELS, AND IS PREFERABLY FORMED FROM TWO CIRCULAR PIECES OF PLASTIC MATERIAL, SEALED AT THE PERIPHERY, AND IN A CENTRALLY-LOCATED SEGMENT TO PROVIDE THE DESIRED CONFIGURATION. A CENTRAL HUB PROVIDES ONE FLUID ENTRANCE AND EXIT. A PERIPHERALLY-LOCATED OUTPUT TUBE, APPROPRIATELY SEALED, IS LOCATED OPPOSITE A SLITTED FLAP, TO PROVIDE MEANS FOR SUSPENDING THE CONTAINER FROM A SUPPORT AND DRAINING THE CONTAINER BY GRAVITY THROUGH THE OUTLET TUBE. A SAMPLING TUBE MAY ALSO BE PROVIDED, CONNECTED TO THE PERIPHERY OF THE BAG.

Description

July 24, 1973 A. L. JONES ETAL CENTRIFUGE FLUID CONTAINER Filed Jan. 28, 1972 FIG. 2
FIG. 3
United States Patent Oflice 3,748,101 Patented July 24, 1973 ABSTRACT OF THE DISCLOSURE A fluid container particularly useful in a system for processing blood. The container is generally annular or toroidal in shape, with a central hub portion which communicates with the annular portion via a plurality of radial channels, and is preferably formed from two circular pieces of plastic material, sealed at the periphery, and in centrally-located segments to provide the desired configuration. A central hub provides one fluid entrance and exit. A peripherally-located output tube, appropriately sealed, is located opposite a slitted flap, to provide means for suspending the container from a support and draining the container by gravity through the outlet tube. A sampling tube may also be provided, connected to the periphery of the bag.
BACKGROUND OF THE INVENTION A copending patent application, Ser. No. 211,194 filed on Dec. 23, 1971 discloses and claims a blood processing system in which thawed frozen blood is washed to remove glycerol or other cryopreservative agents. This system requires a blood container which is circular in shape and has a centrally-located fluid inlet/outlet tube. The present invention provides an improved fluid container for use in the referenced blood processing system.
DESCRIPTION OF PRIOR ART Bag-like containers for holding blood or other fluids for processing are known in the art, including the provision of suitable inlet and outlet tubes, as shown for example in U.S. Pat. 3,545,671. However, none of the known prior art provides a fluid container having a configuration similar to that provided by this invention.
SUMMARY OF THE INVENTION It is a general object of this invention to provide an improved fluid container.
A specific object of the invention is to provide an improved fluid container for processing thawed blood including a centrifuging step.
A further object of the invention is to provide an improved blood container for centrifuging incorporating radial fluid channels to exclude the blood mixture from the low G force area near the center of rotation.
The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of a preferred embodiment of the invention, as illustrated in the accompanying drawings, and described in connection therewith in the annexed specification.
Briefly described, the fluid container provided by this invention is an annular or toroidal-shaped container when filled with fluid. It is preferably formed by sealing two identical circular pieces of suitable flexible elastic material, such as medical-grade polyvinylchloride, at the periphery thereof to provide an enclosed volume. A plurality of sector-shaped areas, centrally located, are formed by sealing the two sides of the bag together. This provides a central or hub portion which communicates with the annular outer portion by a plurality of radial channels. A fluid inlet/outlet tube is located on the axis of the bag, to permit entrance and exit of fluid via the radial channels. (The radial channels confine the major volume of the blood to the outer portions of the bag, where higher G forces are available, and centrifuging time is accordingly reduced.)
A sealed outlet tube is provided at the periphery of the bag, and a hanger opening is provided diametrically opposite the outlet tube, so that the bag can be suspended from a suitable support and drained by gravity via tubing attached to the bag by way of the outlet tube.
A sampling tube may also be provided, having one end connected to the bag at the periphery thereof.
BRIEF DESCRIPTION OF DRAWINGS In the drawings: FIG. 1 is a diagrammatic plan view of a fluid container comprising a preferred embodiment of the invention;
Similar reference characters refer to similar parts in each of the several views.
DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT Referring to the drawings, the fluid container is circular in general shape as manifest in FIGS. 1 and 3. Two circular pieces 3a and 3b of suitable dimensions, of material suited to the purpose, such as medical-grade polyvinylchloride, are sealed together at their periphery, as by application of suitable heat and pressure. In the central portion of the bag thus formed, a plurality of sectorshaped areas 5 of the two sides 3a and 3b are further sealed together to be liquid tight. It is apparent that this configuration will then provide a plurality of radial channels 7 extending outwardly from the center of the bag. There are also provided four holes or openings 9 punched or otherwise formed in the bag structure. These openings fit over bosses or projections in the centrifuge bowl and serve to anchor the bag during rotation.
Located on the central axis of the bag is a fluid inlet/ outlet hub 11. Insertion of a suitable tubing connector provided with a rotating seal, not shown, permits fluid to be supplied to or withdrawn from the bag during centrifuging.
To facilitate the administration of processed blood, an outlet tube 15 can be provided at the periphery of the bag. This tube can be of semi-rigid plastic material, entering the bag radially as shown, and appropriately sealed in place. An inner cap 17 and an outer cap 19 are shown. Inner cap 17 prevents exit of the bag contents during processing while cap 19 protects the sterility of the interior of the outlet tube. In use, the outer cap 19 would be removed, and the stabber or cannula of a suitable tubing set would be thrust into tube 15, the end of the cannula forcing off the cap 17 to permit outward flow of the bag contents.
Opposite the outlet tube 15, the rim of the bag 'is slit as shown at 21, to permit the bag to be suspended from a suitable support when draining through outlet tube 15.
A sampling tube 25 may also be provided, one end of which is attached to the periphery of the bag, and the other end of which is closed, as by heating sealing. In accordance with usual practice, a portion of the bag contents may be expressed into the coupling tube, and then the tube may be cut off and sealed near its connection to the bag, so that the contents of the sampling tube can be used for tests.
It will be apparent from the foregoing that the present invention provides an improved fluid container, particularly suited for centrifuging of blood, which is economi i cal to manufacture, maximizes exposure to G force, thereby reducing time of centrifugation, and is adapted to dispense the contained blood or other fluid in conventional manner.
While the invention has been particularly shown and described with reference to a preferred embodiment thereof, it will be understood by those skilled in the art that the foregoing and other changes in form and details may be made therein without departing from the spirit and scope of the invention.
What is claimed is:
1. A flexible collapsible blood processing container comprising,
an annular outer portion having a toroidal cross section when filled,
a central hub portion having an axially-aligned inlet/ outlet tube connection, a plurality of radial channels integrally formed and extending radially from said hub portion to said outer portion,
a plurality of sector-shaped spacer portions interspersed with said channels,
locator openings situated in said spacer portions, and
an outlet tube sealed in the periphery of said container.
2. A container as claimed in claim 1 in which said container is fomed from two circular pieces of material, sealed together at the periphery thereof, and sealed together at selected sector-shaped central portions to form said central hub portion and said channels.
3. A container as claimed in claim 1, in which inner and outer caps are provided on the inner and outer ends, respectively, of said outlet tube.
4. A container as claimed in claim 1, in which a sampling tube is provided, having one end thereof sealed in theperiphery of said container and communicating with the interior of the container.
References Cited UNITED STATES PATENTS GEORGE H. KRIZMANICH, Primary Examiner U.S. Cl. X.R. 233-26
US00221530A 1972-01-28 1972-01-28 Centrifuge fluid container Expired - Lifetime US3748101A (en)

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AU (1) AU469904B2 (en)
BE (1) BE794220A (en)
BR (1) BR7300608D0 (en)
CA (1) CA971143A (en)
CH (1) CH542106A (en)
DE (1) DE2262856C3 (en)
FR (1) FR2175400A5 (en)
GB (1) GB1374050A (en)
IT (1) IT971834B (en)
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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007871A (en) * 1975-11-13 1977-02-15 International Business Machines Corporation Centrifuge fluid container
US4010894A (en) * 1975-11-21 1977-03-08 International Business Machines Corporation Centrifuge fluid container
US4052164A (en) * 1972-11-26 1977-10-04 Compur-Electronic Gesellschaft Mit Beschrankter Haftung Apparatus for centrifugal separation and measurement of samples
US4052165A (en) * 1975-11-26 1977-10-04 Compur-Electronic Gesellschaft Mit Beschrankter Haftung Apparatus for centrifugal separation of test samples
US4076169A (en) * 1974-10-09 1978-02-28 Schlutz Charles A Centrifuge separation and washing device and method
US4278202A (en) * 1978-07-25 1981-07-14 Separek Teknik Ab Centrifuge rotor and collapsible separation container for use therewith
US4409820A (en) * 1981-06-17 1983-10-18 Irwin Nash Apparatus and method for use in quantitative analysis of a fluid suspension
US4482342A (en) * 1982-06-17 1984-11-13 Haemonetics Corporation Blood processing system for cell washing
FR2590023A1 (en) * 1985-11-14 1987-05-15 Tiyoda Seisakusho Kk CELL USED FOR THE DEPOSITION OF SOLID SUBSTANCES ON AN OBJECT BLADE UNDER THE ACTION OF A CENTRIFUGAL FORCE
US4934995A (en) * 1977-08-12 1990-06-19 Baxter International Inc. Blood component centrifuge having collapsible inner liner
US4939087A (en) * 1987-05-12 1990-07-03 Washington State University Research Foundation, Inc. Method for continuous centrifugal bioprocessing
US5006103A (en) * 1977-08-12 1991-04-09 Baxter International Inc. Disposable container for a centrifuge
US5217426A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Combination disposable plastic blood receiving container and blood component centrifuge
US5217427A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Centrifuge assembly
US5360542A (en) * 1991-12-23 1994-11-01 Baxter International Inc. Centrifuge with separable bowl and spool elements providing access to the separation chamber
US5362291A (en) * 1991-12-23 1994-11-08 Baxter International Inc. Centrifugal processing system with direct access drawer
US5370802A (en) * 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US5427695A (en) * 1993-07-26 1995-06-27 Baxter International Inc. Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate
US5549834A (en) * 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5571068A (en) * 1977-08-12 1996-11-05 Baxter International Inc. Centrifuge assembly
US5573678A (en) * 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US5628915A (en) * 1987-01-30 1997-05-13 Baxter International Inc. Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions
US5632893A (en) * 1987-01-30 1997-05-27 Baxter Internatinoal Inc. Enhanced yield blood processing systems with angled interface control surface
US5641414A (en) * 1987-01-30 1997-06-24 Baxter International Inc. Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields
US5690835A (en) * 1991-12-23 1997-11-25 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5961842A (en) * 1995-06-07 1999-10-05 Baxter International Inc. Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit
US5980760A (en) * 1997-07-01 1999-11-09 Baxter International Inc. System and methods for harvesting mononuclear cells by recirculation of packed red blood cells
US5993370A (en) * 1987-01-30 1999-11-30 Baxter International Inc. Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma
US6007725A (en) * 1991-12-23 1999-12-28 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US6027657A (en) * 1997-07-01 2000-02-22 Baxter International Inc. Systems and methods for collecting diluted mononuclear cells
US6511411B1 (en) 1987-01-30 2003-01-28 Baxter International Inc. Compact enhanced yield blood processing systems
US6582349B1 (en) 1997-07-01 2003-06-24 Baxter International Inc. Blood processing system
US6736768B2 (en) 2000-11-02 2004-05-18 Gambro Inc Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach
US20050113237A1 (en) * 2003-11-25 2005-05-26 Keith Rosiello Integral seal for centrifuge chamber
US20080215029A1 (en) * 1993-01-22 2008-09-04 I-Flow Corporation Platen pump
US20130130382A1 (en) * 2010-08-03 2013-05-23 Sapporo Medical University Autoserum-containing bone marrow cell culture system, autoserum-containing bone marrow cell culture method, and method for producing medicinal composition comprising autoserum-containing cultured bone marrow cells as active ingredient

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NL7706292A (en) * 1976-06-09 1977-12-13 Electro Nucleonics BOWLS SERIES.
DE4226974C2 (en) * 1992-08-14 1994-08-11 Fresenius Ag Method and device for the continuous preparation of a cell suspension
DE19802321C2 (en) * 1998-01-23 2000-05-11 Fresenius Ag Method and device for the preparation of intra- or post-operative blood loss for autotransfusion
CN105501675A (en) * 2016-02-14 2016-04-20 宗士香 Conveying rack for infectious disease department

Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052164A (en) * 1972-11-26 1977-10-04 Compur-Electronic Gesellschaft Mit Beschrankter Haftung Apparatus for centrifugal separation and measurement of samples
US4076169A (en) * 1974-10-09 1978-02-28 Schlutz Charles A Centrifuge separation and washing device and method
US4007871A (en) * 1975-11-13 1977-02-15 International Business Machines Corporation Centrifuge fluid container
US4010894A (en) * 1975-11-21 1977-03-08 International Business Machines Corporation Centrifuge fluid container
US4052165A (en) * 1975-11-26 1977-10-04 Compur-Electronic Gesellschaft Mit Beschrankter Haftung Apparatus for centrifugal separation of test samples
US4934995A (en) * 1977-08-12 1990-06-19 Baxter International Inc. Blood component centrifuge having collapsible inner liner
US5571068A (en) * 1977-08-12 1996-11-05 Baxter International Inc. Centrifuge assembly
US5759147A (en) * 1977-08-12 1998-06-02 Baxter International Inc. Blood separation chamber
US5006103A (en) * 1977-08-12 1991-04-09 Baxter International Inc. Disposable container for a centrifuge
US5217426A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Combination disposable plastic blood receiving container and blood component centrifuge
US5217427A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Centrifuge assembly
US4278202A (en) * 1978-07-25 1981-07-14 Separek Teknik Ab Centrifuge rotor and collapsible separation container for use therewith
US4409820A (en) * 1981-06-17 1983-10-18 Irwin Nash Apparatus and method for use in quantitative analysis of a fluid suspension
US4482342A (en) * 1982-06-17 1984-11-13 Haemonetics Corporation Blood processing system for cell washing
FR2590023A1 (en) * 1985-11-14 1987-05-15 Tiyoda Seisakusho Kk CELL USED FOR THE DEPOSITION OF SOLID SUBSTANCES ON AN OBJECT BLADE UNDER THE ACTION OF A CENTRIFUGAL FORCE
US5641414A (en) * 1987-01-30 1997-06-24 Baxter International Inc. Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields
US5807492A (en) * 1987-01-30 1998-09-15 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cell
US6899666B2 (en) 1987-01-30 2005-05-31 Baxter International Inc. Blood processing systems and methods
US5529691A (en) * 1987-01-30 1996-06-25 Baxter International Inc. Enhanced yield platelet collection systems and method
US20030102272A1 (en) * 1987-01-30 2003-06-05 Baxter International Inc. Blood processing systems and methods
US6511411B1 (en) 1987-01-30 2003-01-28 Baxter International Inc. Compact enhanced yield blood processing systems
US5573678A (en) * 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US5628915A (en) * 1987-01-30 1997-05-13 Baxter International Inc. Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions
US5632893A (en) * 1987-01-30 1997-05-27 Baxter Internatinoal Inc. Enhanced yield blood processing systems with angled interface control surface
US5370802A (en) * 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US5993370A (en) * 1987-01-30 1999-11-30 Baxter International Inc. Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma
US5750039A (en) * 1987-01-30 1998-05-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US4939087A (en) * 1987-05-12 1990-07-03 Washington State University Research Foundation, Inc. Method for continuous centrifugal bioprocessing
US5360542A (en) * 1991-12-23 1994-11-01 Baxter International Inc. Centrifuge with separable bowl and spool elements providing access to the separation chamber
US5804079A (en) * 1991-12-23 1998-09-08 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5690835A (en) * 1991-12-23 1997-11-25 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US6007725A (en) * 1991-12-23 1999-12-28 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US6071421A (en) * 1991-12-23 2000-06-06 Baxter International Inc. Systems and methods for obtaining a platelet suspension having a reduced number of leukocytes
US5362291A (en) * 1991-12-23 1994-11-08 Baxter International Inc. Centrifugal processing system with direct access drawer
US5549834A (en) * 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US20080215029A1 (en) * 1993-01-22 2008-09-04 I-Flow Corporation Platen pump
US5427695A (en) * 1993-07-26 1995-06-27 Baxter International Inc. Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate
US5961842A (en) * 1995-06-07 1999-10-05 Baxter International Inc. Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit
US20030211927A1 (en) * 1997-07-01 2003-11-13 Baxter International Inc. Blood processing chamber counter-balanced with blood-free liquid
US6582349B1 (en) 1997-07-01 2003-06-24 Baxter International Inc. Blood processing system
US6027657A (en) * 1997-07-01 2000-02-22 Baxter International Inc. Systems and methods for collecting diluted mononuclear cells
US5980760A (en) * 1997-07-01 1999-11-09 Baxter International Inc. System and methods for harvesting mononuclear cells by recirculation of packed red blood cells
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Publication number Publication date
NL167613C (en) 1982-01-18
FR2175400A5 (en) 1973-10-19
CA971143A (en) 1975-07-15
IT971834B (en) 1974-05-10
BR7300608D0 (en) 1973-10-25
CH542106A (en) 1973-09-30
JPS554270B2 (en) 1980-01-29
DE2262856C3 (en) 1979-11-15
BE794220A (en) 1973-05-16
NL7217784A (en) 1973-07-31
ZA73285B (en) 1974-08-28
JPS4884078A (en) 1973-11-08
AU5017172A (en) 1974-06-20
GB1374050A (en) 1974-11-13
DE2262856B2 (en) 1979-03-22
NL167613B (en) 1981-08-17
AU469904B2 (en) 1976-02-26
DE2262856A1 (en) 1973-08-16

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