|Numéro de publication||US3830239 A|
|Type de publication||Octroi|
|Date de publication||20 août 1974|
|Date de dépôt||12 sept. 1972|
|Date de priorité||12 sept. 1972|
|Autre référence de publication||CA989633A, CA989633A1, DE2345771A1, DE2345771C2|
|Numéro de publication||US 3830239 A, US 3830239A, US-A-3830239, US3830239 A, US3830239A|
|Inventeurs||Andera J, Stumpf J|
|Cessionnaire d'origine||Frigitronics Of Conn Inc|
|Exporter la citation||BiBTeX, EndNote, RefMan|
|Citations de brevets (7), Référencé par (104), Classifications (8), Événements juridiques (8)|
|Liens externes: USPTO, Cession USPTO, Espacenet|
Stumpf et a].
[ CRYOSURGICAL DEVICE  Inventors: Joseph G. Stumpf, Fairfield; Joseph F. Andera, Trumbull, both of Conn.
 Assignee: Frigitronics 01 Conn., 1nc., Shelton,
 Filed: Sept. 12, 1972 ] Appl. No.: 288,363
 U.S. Cl l28/303.1, 62/293, 62/294  Int. Cl A61b 17/36  Field of Search 62/293, 294; 128/303.l; 222/81  References Cited UNITED STATES PATENTS 1,617,066 2/1927 Lush 222/81 1,897,723 2/1933 Free 62/294 3,190,081 6/1965 Pytryga l28/303.1 UX 3,434,477 3/1969 Thomas, Jr. 128/303.1 3,524,446 8/1970 Crump 128/303.l 3,575,176 4/1971 Crump 128/3031 3,618,610 11/1971 Hannant 128/303.1
11] 3,830,239 Aug. 20, 1974 Primary Examiner-Channing L. Pace Attorney, Agent, or Firm-Buckles and Bramblett [5 7 ABSTRACT The foregoing abstract is not to be taken either as a complete exposition or as a limitation of the present invention. In order to understand the full nature and extent of the technical disclosure of this application, reference must be had to the following detailed description and the accompanying drawings as well as to the claims.
12 Claims, 4 Drawing Figures CRYOSURGICAL DEVICE BACKGROUND OF THE INVENTION This invention pertains to a cryosurgical device employing a low boiling temperature liquid refrigerant. More particularly, it relates to such a device which is self-contained, disposable, and of small size rendering it particularly useful for the cryoextraction of cata racts.
A number of cryosurgical devices have been known to the prior art which are self-contained units and which customarily employ a low boiling refrigerant, such as Freon. Examples of such devices will be found in the following U.S. Pat. Nos.:
2,645,097 Posch 3,343,544 Dunn et al.
3,524,446 Crump et al.
3,529,131 Kanbar et al.
3,575,176 Crump et al.
All of the foregoing are characterized by being selfcontained units which enclose a container of pressurized, low boiling temperature, liquid refrigerant. The refrigerant is selectively released from the container into a separate boiler tip. Boiling of the refrigerant reduces the temperature of the tip which is thereupon used for the surgical procedure. One such surgical procedure is adhesion to a cataractous lens for its removal in cataract surgery. Another type of prior art device is disclosed in U.S. Pat. No. 3,270,744 of Katz et al. That device, however, is not normally in a ready condition. It is always vented and accordingly must be separately filled with liquid nitrogen for each use.
It is an object of the present invention to provide a cryosurgical device which is disposable and of small size. Other objects are to provide such a device which is maintained ready for use over long periods of time; which may be simply and quickly actuated when desired; and which does not require transport of liquid refrigerant from its normal container to a separate boiling chamber.
The manner in which the foregoing objects are achieved will be apparent from the following description and appended claims.
SUMMARY OF THE INVENTION In accordance with the present invention there is provided a self-contained, disposable, cryosurgical device incorporating an elongated, sealed container having a first end terminating in a heat conductive tip, and a second end. A liquefied refrigerant partially fills the container and is normally maintained therein at superatmospheric pressure. An insulating housing substantially encloses the container and exposes at least a portion of the tip. Means are provided for selectively venting the container to atmosphere to boil the refrigerant and cool the tip.
BRIEF DESCRIPTION OF THE DRAWING FIG. 1 is a perspective view of a cryosurgical apparatus in accordance with this invention;
FIG. 2 is an enlarged vertical cross section of the apparatus of FIG. 1;
FIG. 3 is a-further enlarged cross section of the operating mechanism of the device of FIG. 2; and
FIG. 4 is a view similar to FIG. 3 illustrating an alternative operating mechanism.
DESCRIPTION OF THE PREFERRED EMBODIMENT With particular reference to FIGS. 1 and 2, there is illustrated a cryosurgical device in accordance with this invention which has the same size and shape as a conventional ballpoint pen. It comprises a housing 10 comprising an upper housing 10a, a central barrel 10b, and a tip housing 10c. The housing is preferably formed of a material having poor heat conductance, such as nylon, polypropylene, an acrylic, or other suitable material. Upper housing 1.0a is closed at its upper end but defines a crylindrical guideway 12 and small vents 13. The inside of barrel 10b has a substantially cylindrical surface 14. The tip housing 10c has an internal tapering surface 16 terminating in a cylindrical passage 18.
Mounted within the housing 10 is a refrigerant container 20. As will be seen from FIG. 3, the upper end of container 20 defines a circular shoulder 22 defining a central opening 24. A cup shaped cap 26 is crimped over the shoulder 22 and defines a central opening 28. Sealed between the upper end of the container 20 and the cap 26 is a rubber diaphragm 30. The tapered lower end of container 20 terminates at a solid, rod-like tip 32 at a matching conical portion 34 of the tip. The tip portions 32, 34 are fabricated from a suitable heat conductive material. -It is important to note that container 20 is secured within the housing 10 by contact made only at the cap 26 and at the tip portion 34. The remainder of the container is displaced from the housing 10 to provide a dead air insulating space 36.
Mounted in the guideway 12 of upper housing 10a is an actuating plunger 38 upon which is mounted a hollow needle 44 aligned with the opening 28 in cap 26. A small vent hole 46 is drilled in the side of the hollow needle 44. Contained within upper housing is a plug 47 of felt or other porous, fibrous, or blotter-like material. The plug 47 defines a passage 49 for needle 44.
The device of this invention is supplied to the surgeon with the container 28 partially filled with a suitable liquid refrigerant 51, such as Freon 12 or Freon 500. For cataract surgery the apparatus is normally used in an upright position, such as illustrated in FIG. 2. In this position there is a vapor space in the upper region of the container 20. The sealing action of diaphragm 30 causes the vapor and liquid refrigerant to be maintained under pressure at room temperature. When employing Freon 12, this pressure is approximately psig while, when employing Freon 500, the pressure is approximately psig.
When the surgeon wishes to activate the device, he simply depresses the actuating plunger 38. This causes the needle 44 to pierce the diaphragm 30. The vaporized refrigerant then passes into needle 44 and through vent hole 46, plug 47, and vents 13 to atmosphere. Reduction of the pressure within container 20 to atmosphere causes the remaining liquid refrigerant to immediately begin boiling and the entire volume of liquid refrigerant drops to its boiling temperature. For Freon 12 this is -21F, for Freon 500 it is 28F. This causes heat to be rapidly extracted from the tip 32, reducing its temperature and permitting it to be employed for the preferred surgical operation. For a device of the described size, the tip temperature remains at this lower value for approximately 4 minutes, a time amply sufficient to perform the usual cryoextraction. After use, the instrument is simply discarded.
The function of the plug 47 is to soak up any liquid refrigerant while allowing gaseous refrigerant to pass. Several conditions may cause liquid to be present in the upper housing including: the container being too full; violent boiling of the liquid; sloshing of the liquid due to motion of the surgeons hand; or activation while in other than a vertical position.
An alternative embodiment of the invention is illustrated in FIG. 4. In this embodiment, the needle and diaphragm are replaced by a conventional valve. In the illustration of FIG. 4, parts similar to those previously described have been given identical numerals but with a prime attached. In this embodiment, the puncturable diaphragm is replaced by a valving diaphragm 50 which has an outer annular flange 52 which is engaged by the crimped cap 54 to retain it in place. The valve diaphragm has an enlarged central portion 56 which seals the container by contacting the central opening 58 in the cap. A sidewardly positioned vent 60 in the diaphragm is normally closed by engagement with the cap. The hollow needle is replaced by a reduced diameter stem 62 on the end of a plunger 64. Downward movement of the plunger depresses the central portion 56 of the diaphragm permitting the vapor to exhaust through vent 60 and opening 58 to atmosphere. In the version illustrated in FIG. 4, the plunger 64 is retained in the open valve position by means of a detent 66 which overrides an internal shoulder 68 in the housing. This construction could be modified by making plunger 64 retractable, such as the button on a ballpoint pen. The valve could then be closed to permit defrosting during a surgical procedure.
It is believed that the many advantages of this invention will now be apparent to those skilled in the art. It will be particularly apparent that no transfer of the refrigerant is required in order to effectuate the desired cooling. As a result, the device is much smaller and of simpler construction than devices known to the prior art. It will also be apparent that a number of variations and modifications may be made in this invention without departing from its spirit and scope. Accordingly, the foregoing description is to be construed as illustrative only, rather than limiting. This invention is limited only by the scope of the following claims.
1. A self-contained, disposable cryosurgical device which comprises: an elongated, sealed container having a first end terminating in an integral heat conductive applicator tip, and a second end; a liquefied refrigerant partially filling said container to define a vapor space therein and normally maintained at super atmospheric pressure, said liquid being in direct physical contact with said tip; an insulating housing substantially enclosing said container but exposing at least a portion of said tip; and means at said second end for selectively venting the vapor space of said container to atmosphere to boil said refrigerant and cool said container and tip.
2. The device of claim 1 wherein said venting means comprises a porous member for passage of refrigerant therethrough.
3. The device of claim ll wherein said venting means comprises a needle actuatable to puncture the second end of said container.
4. The device of claim 3 wherein said needle is secured to an actuating plunger supported in said housing.
5. The device of claim 4 wherein said venting means comprises a porous member surrounding said needle.
6. The device of claim 1 wherein the second end of said container comprises an elastomeric diaphragm.
7. The device of claim 6 wherein said venting means comprises a needle actuatable to puncture said diaphragm.
8. The device of claim 7 wherein said needle is secured to an actuating plunger supported in said housmg.
9. The device of claim 1 wherein the second end of said container comprises a valve and said venting means comprises a valve actuator.
10. The device of claim 9 wherein said valve actuator comprises a plunger supported in said housing.
11. The device of claim 10 wherein said valve comprises an elastomeric diaphragm normally sealing said second end but movable to an open position by said plunger.
12. The device of claim 11 wherein said plunger includes means for retaining said diaphragm in its open position.
|Brevet cité||Date de dépôt||Date de publication||Déposant||Titre|
|US1617066 *||3 nov. 1925||8 févr. 1927||Lush Studley Woolcott||Means for decanting liquids from metal containers|
|US1897723 *||29 avr. 1927||14 févr. 1933||Free Walter H||Refrigerating device|
|US3190081 *||26 juil. 1963||22 juin 1965||Sulfrian Cryogenics Inc||Cryogenic applicator with probe means|
|US3434477 *||23 nov. 1966||25 mars 1969||Univ Northwestern||Surgical instrument|
|US3524446 *||31 mai 1968||18 août 1970||Frigitronics Of Conn Inc||Disposable cryosurgical instrument|
|US3575176 *||21 oct. 1968||20 avr. 1971||Frigitronics Of Conn Inc||Rechargeable cryosurgical instrument|
|US3618610 *||22 avr. 1970||9 nov. 1971||Kidde & Co Walter||Cryogenic surgical apparatus|
|Brevet citant||Date de dépôt||Date de publication||Déposant||Titre|
|US4602628 *||17 janv. 1985||29 juil. 1986||Allen Jr Robert E||Cryogenic extractor and filler|
|US4735063 *||13 avr. 1987||5 avr. 1988||Superior Marketing Research Corp.||Self-contained cooling device|
|US5042261 *||30 janv. 1990||27 août 1991||Cornwell Corporation||Tissue freezing process|
|US6039730 *||24 juin 1996||21 mars 2000||Allegheny-Singer Research Institute||Method and apparatus for cryosurgery|
|US6161543 *||15 oct. 1997||19 déc. 2000||Epicor, Inc.||Methods of epicardial ablation for creating a lesion around the pulmonary veins|
|US7083620||17 juil. 2003||1 août 2006||Medtronic, Inc.||Electrosurgical hemostat|
|US7094235||13 janv. 2004||22 août 2006||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US7118566||3 févr. 2003||10 oct. 2006||Medtronic, Inc.||Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue|
|US7128740||2 avr. 2003||31 oct. 2006||Jacobs Clemens J||Method for interrupting conduction paths within the heart|
|US7156845||16 sept. 2005||2 janv. 2007||Medtronic, Inc.||Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue|
|US7166105||20 sept. 2005||23 janv. 2007||Medtronic, Inc.||Pen-type electrosurgical instrument|
|US7169144||31 oct. 2003||30 janv. 2007||Medtronic, Inc.||Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue|
|US7247155||18 mai 2004||24 juil. 2007||Medtronic, Inc.||Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue|
|US7250048||20 août 2004||31 juil. 2007||Medtronic, Inc.||Ablation system and method of use|
|US7250051||26 avr. 2006||31 juil. 2007||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US7294143||3 févr. 2003||13 nov. 2007||Medtronic, Inc.||Device and method for ablation of cardiac tissue|
|US7309325||28 juin 2005||18 déc. 2007||Medtronic, Inc.||Helical needle apparatus for creating a virtual electrode used for the ablation of tissue|
|US7347858||14 oct. 2003||25 mars 2008||Medtronic, Inc.||Method and system for treatment of atrial tachyarrhythmias|
|US7364578||3 déc. 2004||29 avr. 2008||Medtronic, Inc.||System and method of performing an electrosurgical procedure|
|US7367972||9 sept. 2003||6 mai 2008||Medtronic, Inc.||Ablation system|
|US7422588||7 déc. 2006||9 sept. 2008||Medtronic, Inc.||Pen-type electrosurgical instrument|
|US7435250||18 févr. 2005||14 oct. 2008||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US7470272||30 juin 2004||30 déc. 2008||Medtronic, Inc.||Device and method for ablating tissue|
|US7497857||29 avr. 2003||3 mars 2009||Medtronic, Inc.||Endocardial dispersive electrode for use with a monopolar RF ablation pen|
|US7507235||28 mai 2002||24 mars 2009||Medtronic, Inc.||Method and system for organ positioning and stabilization|
|US7513891 *||15 juil. 2005||7 avr. 2009||Disetronic Licensing Ag||Temperature-sensitive cannula|
|US7566334||2 juin 2005||28 juil. 2009||Medtronic, Inc.||Ablation device with jaws|
|US7615015||20 juin 2003||10 nov. 2009||Medtronic, Inc.||Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same|
|US7628780||30 nov. 2004||8 déc. 2009||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7678108||2 juin 2005||16 mars 2010||Medtronic, Inc.||Loop ablation apparatus and method|
|US7678111||29 nov. 2005||16 mars 2010||Medtronic, Inc.||Device and method for ablating tissue|
|US7699805||30 nov. 2007||20 avr. 2010||Medtronic, Inc.||Helical coil apparatus for ablation of tissue|
|US7706882||13 mai 2005||27 avr. 2010||Medtronic, Inc.||Methods of using high intensity focused ultrasound to form an ablated tissue area|
|US7706894||26 avr. 2005||27 avr. 2010||Medtronic, Inc.||Heart wall ablation/mapping catheter and method|
|US7740623||23 juin 2005||22 juin 2010||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7744562||10 oct. 2006||29 juin 2010||Medtronics, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7758576||2 juin 2005||20 juil. 2010||Medtronic, Inc.||Clamping ablation tool and method|
|US7758580||2 juin 2005||20 juil. 2010||Medtronic, Inc.||Compound bipolar ablation device and method|
|US7794460||11 août 2008||14 sept. 2010||Medtronic, Inc.||Method of ablating tissue|
|US7818039||15 juil. 2005||19 oct. 2010||Medtronic, Inc.||Suction stabilized epicardial ablation devices|
|US7824399||16 févr. 2006||2 nov. 2010||Medtronic, Inc.||Ablation system and method of use|
|US7871409||2 févr. 2009||18 janv. 2011||Medtronic, Inc.||Endocardial dispersive electrode for use with a monopolar RF ablation pen|
|US7875028||8 juil. 2009||25 janv. 2011||Medtronic, Inc.||Ablation device with jaws|
|US7959626||20 juil. 2007||14 juin 2011||Medtronic, Inc.||Transmural ablation systems and methods|
|US7963963||21 janv. 2005||21 juin 2011||Medtronic, Inc.||Electrosurgical hemostat|
|US7967816||25 janv. 2002||28 juin 2011||Medtronic, Inc.||Fluid-assisted electrosurgical instrument with shapeable electrode|
|US7975703||31 août 2006||12 juil. 2011||Medtronic, Inc.||Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue|
|US7998137||12 avr. 2010||16 août 2011||Myoscience, Inc.||Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)|
|US8162933||3 mars 2004||24 avr. 2012||Medtronic, Inc.||Vibration sensitive ablation device and method|
|US8162941||20 déc. 2010||24 avr. 2012||Medtronic, Inc.||Ablation device with jaws|
|US8172837||14 juin 2010||8 mai 2012||Medtronic, Inc.||Clamping ablation tool and method|
|US8221402||9 déc. 2005||17 juil. 2012||Medtronic, Inc.||Method for guiding a medical device|
|US8221415||27 juil. 2007||17 juil. 2012||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US8262649||27 juil. 2007||11 sept. 2012||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US8273072||18 nov. 2009||25 sept. 2012||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US8298216||14 nov. 2008||30 oct. 2012||Myoscience, Inc.||Pain management using cryogenic remodeling|
|US8333764||12 mai 2004||18 déc. 2012||Medtronic, Inc.||Device and method for determining tissue thickness and creating cardiac ablation lesions|
|US8409185||16 févr. 2007||2 avr. 2013||Myoscience, Inc.||Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling|
|US8409219||30 sept. 2009||2 avr. 2013||Medtronic, Inc.||Method and system for placement of electrical lead inside heart|
|US8414573||11 oct. 2006||9 avr. 2013||Medtronic, Inc.||Device and method for ablation of cardiac tissue|
|US8512337||20 août 2004||20 août 2013||Medtronic, Inc.||Method and system for treatment of atrial tachyarrhythmias|
|US8568409||31 oct. 2007||29 oct. 2013||Medtronic Advanced Energy Llc||Fluid-assisted medical devices, systems and methods|
|US8623010||9 juin 2009||7 janv. 2014||Medtronic, Inc.||Cardiac mapping instrument with shapeable electrode|
|US8632533||23 févr. 2010||21 janv. 2014||Medtronic Advanced Energy Llc||Fluid-assisted electrosurgical device|
|US8663245||19 avr. 2007||4 mars 2014||Medtronic, Inc.||Device for occlusion of a left atrial appendage|
|US8706260||27 oct. 2011||22 avr. 2014||Medtronic, Inc.||Heart wall ablation/mapping catheter and method|
|US8715275||13 sept. 2012||6 mai 2014||Myoscience, Inc.||Pain management using cryogenic remodeling|
|US8801707||14 août 2012||12 août 2014||Medtronic, Inc.||Method and devices for treating atrial fibrillation by mass ablation|
|US8821488||13 mai 2009||2 sept. 2014||Medtronic, Inc.||Tissue lesion evaluation|
|US8906012||30 juin 2010||9 déc. 2014||Medtronic Advanced Energy Llc||Electrosurgical devices with wire electrode|
|US8926635||2 oct. 2009||6 janv. 2015||Medtronic, Inc.||Methods and devices for occlusion of an atrial appendage|
|US9017318||22 janv. 2013||28 avr. 2015||Myoscience, Inc.||Cryogenic probe system and method|
|US9066712||22 déc. 2009||30 juin 2015||Myoscience, Inc.||Integrated cryosurgical system with refrigerant and electrical power source|
|US9072498||17 nov. 2010||7 juil. 2015||Myoscience, Inc.||Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)|
|US9101346||30 sept. 2013||11 août 2015||Myoscience, Inc.||Pain management using cryogenic remodeling|
|US9113855||5 mars 2013||25 août 2015||Myoscience, Inc.||Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling|
|US9113896||28 déc. 2007||25 août 2015||Medtronic, Inc.||Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue|
|US9155584||14 janv. 2013||13 oct. 2015||Myoscience, Inc.||Cryogenic probe filtration system|
|US9227088||3 mai 2010||5 janv. 2016||Medtronic, Inc.||Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions|
|US9241753||14 janv. 2013||26 janv. 2016||Myoscience, Inc.||Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments|
|US9254162||21 déc. 2006||9 févr. 2016||Myoscience, Inc.||Dermal and transdermal cryogenic microprobe systems|
|US9295512||12 sept. 2013||29 mars 2016||Myoscience, Inc.||Methods and devices for pain management|
|US9314290||14 janv. 2013||19 avr. 2016||Myoscience, Inc.||Cryogenic needle with freeze zone regulation|
|US9333027 *||3 oct. 2013||10 mai 2016||Medtronic Advanced Energy Llc||Method of producing an electrosurgical device|
|US9345526||7 juil. 2011||24 mai 2016||Myoscience, Inc.||Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)|
|US9381061||23 nov. 2011||5 juil. 2016||Medtronic Advanced Energy Llc||Fluid-assisted medical devices, systems and methods|
|US9486283||20 déc. 2013||8 nov. 2016||Medtronic Advanced Energy Llc||Fluid-assisted electrosurgical device|
|US9610112||18 mars 2014||4 avr. 2017||Myoscience, Inc.||Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis|
|US9656063||2 avr. 2013||23 mai 2017||Medtronic, Inc.||Method and system for placement of electrical lead inside heart|
|US9668800||18 mars 2014||6 juin 2017||Myoscience, Inc.||Methods and systems for treatment of spasticity|
|US9693819||3 janv. 2007||4 juil. 2017||Medtronic, Inc.||Vibration sensitive ablation device and method|
|US20060030824 *||15 juil. 2005||9 févr. 2006||Marcel Hunn||Temperature-sensitive cannula|
|US20080015562 *||20 juil. 2007||17 janv. 2008||Medtronic, Inc.||Transmural ablation systems and methods|
|US20080027419 *||25 juil. 2007||31 janv. 2008||Ams Research Corporation||Cryoprobe with Integral Agent Delivery Device|
|US20080091194 *||30 nov. 2007||17 avr. 2008||Mulier Peter M||Helical coil apparatus for ablation of tissue|
|US20080154254 *||21 déc. 2006||26 juin 2008||Myoscience, Inc.||Dermal and Transdermal Cryogenic Microprobe Systems and Methods|
|US20080200910 *||16 févr. 2007||21 août 2008||Myoscience, Inc.||Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling|
|US20080221561 *||17 juil. 2006||11 sept. 2008||Jorg Geiger||Spray Device for Dispensing a Cooling Fluid|
|US20090248001 *||14 nov. 2008||1 oct. 2009||Myoscience, Inc.||Pain management using cryogenic remodeling|
|US20090270857 *||8 juil. 2009||29 oct. 2009||Christian Steven C||Ablation Device with Jaws|
|US20100145361 *||2 oct. 2009||10 juin 2010||Francischelli David E||Methods and Devices for Occlusion of an Atrial Appendage|
|US20100198207 *||12 avr. 2010||5 août 2010||Myoscience, Inc.||Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)|
|US20140026395 *||3 oct. 2013||30 janv. 2014||Medtronic Advanced Energy Llc||Fluid-assisted electrosurgical devices, and methods of manufacture thereof|
|WO1997049344A1 *||20 juin 1997||31 déc. 1997||Allegheny-Singer Research Institute||Method and apparatus for cryosurgery|
|Classification aux États-Unis||606/25, 62/293, 62/294|
|Classification internationale||A61B18/00, A61F9/007, A61B18/02|
|11 mars 1992||AS||Assignment|
Owner name: COOPERVISION, INC. A NY CORPORATION, NEW YORK
Free format text: NUNC PRO TUNC ASSIGNMENT;ASSIGNOR:FRIGI ACQUISITION, INC., A CORPORATION OF DE;REEL/FRAME:006047/0568
Owner name: FRIGI ACQUISITION, INC., CONNECTICUT
Free format text: NUNC PRO TUNC ASSIGNMENT;ASSIGNOR:COOPERVISION, INC. A CORP. OF NEW YORK;REEL/FRAME:006047/0578
Effective date: 19911004
|11 mars 1992||AS27||Nunc pro tunc assignment|
Free format text: FRIGI ACQUISITION, INC. A DE CORP. 770 RIVER ROAD SHELTON, CONNECTICUT 06484 * COOPERVISION, INC. ACORP. OF NEW YORK : 19911004
|16 juil. 1990||AS||Assignment|
Owner name: FRIGITRONICS OF CONN., INC.
Free format text: RELEASED BY SECURED PARTY;ASSIGNOR:BANK OF NEW YORK COMMERCIAL CORPORATION, THE;REEL/FRAME:005395/0050
Effective date: 19900612
|28 mars 1990||AS||Assignment|
Owner name: FRIGI ACQUISITION, INC., 3145 PORTER DRIVE, PALO A
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:FRIGITRONICS OF CONN., INC.;REEL/FRAME:005262/0818
Effective date: 19900316
Owner name: FRIGI ACQUISITION, INC., A CORP. OF DE, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FRIGITRONICS OF CONN., INC.;REEL/FRAME:005262/0818
|20 mai 1988||AS06||Security interest|
Owner name: BANK OF NEW YORK COMMERCIAL CORPORATION, THE, 530
Owner name: FRIGITRONICS OF CONNECTICUT, INC.,
Effective date: 19870724
|20 mai 1988||AS02||Assignment of assignor's interest|
Owner name: FRIGITRONICS INC., A DE CORPORATION
Effective date: 19870724
Owner name: FRIGITRONICS OF CONN., INC.
|20 mai 1988||AS||Assignment|
Owner name: BANK OF NEW YORK COMMERCIAL CORPORATION, THE, 530
Free format text: SECURITY INTEREST;ASSIGNOR:FRIGITRONICS OF CONNECTICUT, INC.,;REEL/FRAME:004935/0800
Owner name: FRIGITRONICS INC., A DE CORPORATION
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:FRIGITRONICS OF CONN., INC.;REEL/FRAME:004935/0794
Effective date: 19870724
|26 oct. 1987||AS||Assignment|
Owner name: FRIGITRONICS, INC., A CORP. OF DE
Free format text: MERGER;ASSIGNORS:FRIGITRONICS, INC., A CORP. OF CT.;FRIGITRONICS OF CONN., INC., A CORP. OF CT;REEL/FRAME:004858/0780;SIGNING DATES FROM 19680314 TO 19861208