|
| US4045558 | 8 oct. 1975 | 30 août 1977 | Merck & Co., Inc. | Pilocarpine salts |
| US4061722 | 26 avr. 1976 | 6 déc. 1977 | INTERx Research Corporation | Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals |
| US4131651 | 25 oct. 1977 | 26 déc. 1978 | Barnes-Hind Pharmaceuticals, Inc. | Treatment of dry eye |
| US4136145 | 20 juil. 1976 | 23 janv. 1979 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
| US4179497 | 13 nov. 1978 | 18 déc. 1979 | Merck & Co., Inc. | Solid state ophthalmic medication |
| US4248855 | 27 août 1976 | 3 févr. 1981 | Hydrophilics International, Inc. | Pharmaceutical base salts |
| US4259314 | 10 déc. 1979 | 31 mars 1981 | | Method and composition for the preparation of controlled long-acting pharmaceuticals |
| US4281654 | 7 avr. 1980 | 4 août 1981 | ALZA Corporation | Drug delivery system for controlled ocular therapy |
| US4283393 | 13 mars 1979 | 11 août 1981 | Merck & Co., Inc. | Topical application of interferon inducers |
| US4287175 | 1 juin 1979 | 1 sept. 1981 | Merck & Co., Inc. | Contact lens wetting agents |
| US4321261 | 25 juin 1979 | 23 mars 1982 | Polymer Technology Corporation | Ionic ophthalmic solutions |
| US4343787 | 28 déc. 1978 | 10 août 1982 | Merck & Co., Inc. | Shaped ophthalmic inserts for treating dry eye syndrome |
| US4454148 | 9 déc. 1982 | 12 juin 1984 | Merck & Co., Inc. | 5-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure |
| US4738851 | 12 juin 1986 | 19 avr. 1988 | University of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US4865846 | 3 juin 1988 | 12 sept. 1989 | | Drug delivery system |
| US4882150 | 1 mai 1989 | 21 nov. 1989 | | Drug delivery system |
| US4923699 | 3 juin 1988 | 8 mai 1990 | | Eye treatment suspension |
| US4923700 | 3 juin 1988 | 8 mai 1990 | | Artificial tear suspension |
| US5229128 | 1 oct. 1991 | 20 juil. 1993 | | Drug delivery ophthalmic insert and method of preparing same |
| US5234914 | 27 nov. 1991 | 10 août 1993 | Patent Biopharmaceutics, Inc. | Methods of treating hemorrhoids and anorecial disease |
| US5442053 | 19 août 1992 | 15 août 1995 | Fidia, S.p.A. | Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions |
| US5466233 | 25 avr. 1994 | 14 nov. 1995 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
| US5556633 | 28 avr. 1993 | 17 sept. 1996 | | Drug delivery ophthalmic insert and method for preparing same |
| US5767106 | 25 août 1994 | 16 juin 1998 | Hyal Pharmaceutical Corporation | Treatment of disease and conditions associated with macrophage infiltration |
| US5773019 | 27 sept. 1995 | 30 juin 1998 | The University of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| US5792753 | 17 févr. 1993 | 11 août 1998 | Hyal Pharmaceutical Corporation | Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs |
| US5824658 | 7 août 1995 | 20 oct. 1998 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| US5910489 | 19 août 1994 | 8 juin 1999 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| US5962433 | 6 juin 1995 | 5 oct. 1999 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| US5977088 | 6 juin 1995 | 2 nov. 1999 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US5990096 | 6 juin 1995 | 23 nov. 1999 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US6103704 | 17 févr. 1993 | 15 août 2000 | Hyal Pharmaceutical Corporation | Therapeutic methods using hyaluronic acid |
| US6140312 | 6 juin 1995 | 31 oct. 2000 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US6218373 | 6 juin 1995 | 17 avr. 2001 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US6264971 | 4 nov. 1999 | 24 juil. 2001 | BTG International Limited | Ocular insert |
| US8167855 | 25 août 2004 | 1 mai 2012 | Vista Scientific LLC | Ocular drug delivery device |