Recherche Images Maps Play YouTube Actualités Gmail Drive Plus »
Connexion
Les utilisateurs de lecteurs d'écran peuvent cliquer sur ce lien pour activer le mode d'accessibilité. Celui-ci propose les mêmes fonctionnalités principales, mais il est optimisé pour votre lecteur d'écran.

Brevets

  1. Recherche avancée dans les brevets
Numéro de publicationUS3856016 A
Type de publicationOctroi
Date de publication24 déc. 1974
Date de dépôt3 nov. 1972
Date de priorité3 nov. 1972
Autre référence de publicationDE2405390A1
Numéro de publicationUS 3856016 A, US 3856016A, US-A-3856016, US3856016 A, US3856016A
InventeursH Davis
Cessionnaire d'origineH Davis
Exporter la citationBiBTeX, EndNote, RefMan
Liens externes: USPTO, Cession USPTO, Espacenet
Method for mechanically applying an occlusion clip to an anatomical tubular structure
US 3856016 A
Résumé
An occlusion clip which includes two laterally spaced clip portions interconnected at both ends by connecting portions and provided with indexing means in one connecting portion, and an instrument for applying the occlusion clip which includes two jaws movable relative to one another adjacent one end of a tubular structure in such a manner as to close the occlusion clip in a predetermined manner, one of the jaws, particularly the movable jaw being provided with a complementary indexing means and the tubular structure accommodating, if necessary, an optical viewing device as well as a means for emitting a beam of light within the area of the jaws.
Images(3)
Previous page
Next page
Description  (Le texte OCR peut contenir des erreurs.)

United States Patent [1 1 Davis [4 1 Dec. 24, 1974 METHOD FOR MECHANICALLY APPLYING AN OCCLUSION CLIP TO AN ANATOMICAL TUBULAR STRUCTURE [76] Inventor: Hugh J. Davis, 2 E. Highfield Rd.,

Baltimore, Md. 21218 [22] Filed: Nov. 3, 1972 t 21 Appl. No.: 303,314

52 US. Cl 128/325, 128/006, 128/346, 2,2 w 2,/A, ,0, 2 23, W,,. j9 0,. W 51 1m. 0.... A61b 17/12, A61b 17/10, B2ld 5/16 [58 Field o1 S e a rch. 72/409, 410; 24123 W, W 24/305 w; 128/1 R, 2 R, 6, 7, s, 9, 303 R,

[56] References Cited UNITED STATES PATENTS 0,190,641 5/1977 Stouffer 24/023 W 1,482,290 1/1924 Elzi 72/410 2,031,682 2/1936 Wappler et a1, 128/303.15 2,599,662 6/1952 Rosenbaum 128/006 3,613,661 10/1971 Shah 128/346 3,708,149 1/1973 Dinger 24/030.5 W 3,763,860 10/1973 Clarke 128/334 FOREIGN PATENTS OR APPLICATIONS 1,091,700 10/1960 Germany 128/321 OTHER PUBLICATIONS Fiber Optic Laparoscope, Brochure of American Cystoscope Makers, Inc., Pelham Manor, N.Y., February 1972.

Primary Examiner-Channing L. Pace Attorney, Agent, or Firm-Stewart and Kolasch, Ltd.

[57] ABSTRACT An occlusion clip which includes two laterally spaced clip portions interconnected at both ends by connecting portions and provided with indexing means in one connecting portion, and an instrument for applying the occlusion clip which includes two jaws movable relative to one another adjacent one end of a tubular structure in such a manner as to close the occlusion clip in a predetermined manner, one of the jaws, particularly the movable jaw being provided with a complementary indexing means and the tubular structure accommodating, if necessary, an optical viewing device as well as a means for emitting a beam of light within the area of the jaws.

5 Claims, 16 Drawing Figures METHOD FOR MECHANICALLY APPLYING AN OCCLUSION CLIP TO AN ANATOMICAL TUBULAR STRUCTURE The present invention relates to an occlusion clip and to an instrument to apply the occlusion clip.

Various clips are known in the prior art for causing an occlusion of anatomical tubular structures such as blood vessels, veins, etc. A clip designated Hemoclip is known in the art which consists of a thin wire bent into approximately U-shape. While this Hemoclip has been used with some success, certain problems nevertheless exist with this prior art type of occlusion clip because, if the wire is applied too tightly, it will cut into the tubular structure. Furthermore, if the wire of this prior art clip is too narrow, as is the case, then the specific pressure becomes excessively high. Since a certain width is necessary to assure a satisfactory occlusion, it is customary to apply two or three of these so-called Hemoclips to a given anatomical tubular structure. Additionally, these prior art occlusion clips are susceptible, by reason of their construction, of slipping off from the anatomical tubular structure while being applied or even thereafter, i.e., there is always the danger that these prior art clips do not stay in the desired position, thereby resulting in eventual failure of the occlusion.

An instrument called Laparoscope is known in the art for purposes of sterilization by cauterizing fallopian tubes. After causing ballooning of the abdominal wall, a narrow slit is made through the umbilicus to thereafter insert the Laparoscope, and with the assistance of fiber-optics, cauterization is effected. However, this method of sterilization is fraught with certain dangers as some difficulties exist in controlling the degree and extent of cauterization in order to avoid accidental burning of adjacent parts, such as intestinal portions.

The present invention is concerned with the task of providing an occlusion clip which includes means to lock the clip in position during its application so that the clip cannot come off the instrument used for applying the same.

Another advantage of the occlusion clip of the present invention resides in its particular structure forming, in effect, two occlusion clips spaced from one another, thus preventing with certainty re-fertilization without the need of installing two separate clips, as required by the prior art. This is achieved in that the occlusion clip of the present invention is provided with two side portions adjoined by end portions to form a unitary structure installed, as such, on the fallopian tubes or the like which causes simultaneous occlusion at two spaced points.

The instrument in accordance with the present invention is provided with relatively movable jaws at the free end of a tubular member adapted to be inserted through an opening, for example, through the umbilicus whereby the jaws are provided with means to lock the occlusion clip in position while being inserted into the opening formed in the human body for eventual emplacement over the fallopian tubes or the like. By providing one of the jaws with a projecting nose portion and the occlusion clip with a complementary slot, the occlusion clip in accordance with the present invention is securely held in position until actually installed over the anatomical tubular structure.

A further feature of the present invention resides in an instrument which permits direct visual observation by means of an optical system thus assuring a good view during the entire operation, not only for purposes of properly locating the place where the occlusion clip is to be applied but also permitting visual observation during the closing of the occlusion clip by the provision of an appropriate aperture in the movable jaw.

Another advantage of the present invention resides in the particular construction of the jaws to illuminate the area of application and permit viewing through the center of the clip, thus permitting also the application of largerclips.

A further advantage of the instrument in accordance with the present invention resides in the particular location of .the fulcrum for the movable jaw to assure a closing of the free end of the lower jaw first, thereby assuring an occlusion without cutting into any tissues.

Another feature of the present invention resides in the simplicity of the instrument used for applying the occlusion clip which has a convenient pistol grip and permits a good view through its tubular member even when the jaws are closed, thus enabling accurate control in the positioning and application of the occlusion clip.

Accordingly, it is an object of the present invention to provide an occlusion clip and instrument for apply ing the same which avoid by simple means the aforementioned shortcomings and drawbacks encountered in the prior art.

It is another object of the present invention to provide an occlusion clip and instrument for applying the same which substantially eliminate failures in the occlusion due to faulty application.

A further object of the present invention resides in an occlusion clip and instrument for applying the same which will provide occlusion at spaced points to minimize the likelihood of eventual failure of the occlusion.

Still another object of the present invention resides in an occlusion clip of the type described above which permits permeation likely to encourage fibrosis to assure a permanent interruption in the anatomical tubular structure.

Still a further object of the present invention resides in an occlusion clip and instrument for applying the same which assure reliable locking of the clip onto the instrument during the operation.

A still further object of the present invention resides in an occlusion clip which is relatively simple in construction yet assures an occlusion at two spatially separated points, thus obviating the need for the application of several clips to guarantee the success of the occlusion.

Another object of the present invention resides in an instrument for applying the occlusion clip of the present invention which is simple in construction, reliable in operation and permits easy handling by the availability of an optical viewing system enabling the doctor to visually follow the positioning and application of the clip throughout the entire operation.

These and further objects, fearures and advantages of the present invention will become more apparent from the following description when taken in connection with the accompanying drawing which shows, for purposes of illustration only, several embodiments in ac cordance with the present invention, and wherein:

FIG. 1 is a plan view of an occlusion clip blank in accordance with the present invention;

FIG. 2 is a perspective view of a clip formed from the blank of FIG. 1 by bending the blank back upon itself into a configuration ready for insertion into the open jaws of the instrument;

FIG. 3 is a somewhat schematic side view illustrating the application of the occlusion clip shown in FIG. 2 on an anatomical tubular structure;

FIG. 4 is a fragmentary view showing the occlusion clip clamped on the anatomical tubular structure of FIG. 3;

FIG. 5 is a side view of an instrument in accordance with the present invention for applying the occlusion clip of FIG. 2 on the anatomical tubular structure;

FIG. 6 is a fragmentary view, partially in longitudinal cross section, through certain parts of the instrument of FIG. 5;

FIG. 7 is an exploded perspective view of the distal part of the instrument of FIGS. 5 and 6;

FIG. 8 is enlarged side view of the distal part of the instrument of FIG. 5 illustrating the jaw portions thereof;

FIG. 9 is a perspective, exploded view of the proximal part of the instrument shown in FIG. 5;

FIG. 10 is a cross-sectional view, on an enlarged scale, through the instrument of the present invention taken along line XX of FIG. 6;

FIG. 11 is a perspective view, on an enlarged scale, of the distal part of the instrument in accordance with the present invention;

FIG. 12 is a perspective view of the occlusion clip in relation to the anatomical tubular structure at the beginning of its application;

FIG. 13 is a perspective view, similar to FIG. 12 and showing the relationship of the occlusion clip to the anatomical tubular structure as the application proceeds;

FIG. 14 is a perspective of the distal part of a modified embodiment of an instrument in accordance with the present invention; and

FIGS. 15a and 15b are schematic side views comparing the installed clip of the present invention with the installed clip of the prior art, respectively.

Referring now to the drawing wherein like reference numerals are used throughout the various views to designate like parts, the occlusion clip blank generally designated by reference numeral 10 is in the form of a unitary structure which includes two lateral portions 24 and 25, constituting in effect two occlusion clip members spatially separated from one another, a connecting portion 26 at the upper end, as viewed in FIG. 1 which connects the side portions 24 and 25 and a connecting portion 27 connecting the side portions 24 and 25 at the lower end. An indexing aperture 14 is also provided in the lower connecting portion 27 which is intended to engage with an indexing projection 38 (FIGS. 3, 8, and 11) provided on the fixed jaw 34 of the instrument of this invention for positioning the occlusion clip 10 in relation to the instrument and to thereby secure the same in position.

It will be appreciated that the occlusion clip of FIGS. 1 and 2 provides in effect for an elongated opening or hiatus 12 defining a herniating portion between the laterally spaced clip members 24 and 25. A transverse divider portion 18 thereby separates this hiatus 12 from the indexing aperture 14.

For purposes of use with the instrument in accordance with the present invention, the occlusion clip blank 10 made of suitable flexible material is bent back upon itself about the flex line 16 to provide two half portions generally designated by reference numerals 20 and 22 such as illustrated in FIG. 2. The blank 10 should thereby be bent only to such an extent that the two portions 20 and 22 subtend therebetween an angle slightly larger than the angle of the two jaws 32 and 34 when in the fully opened position as shown in FIG. 3 so that the occlusion clip will securely retained in place by engagement of its aperture 14 with the nose-like indexing projection 38.

It may also be appropriate to impart a curved configuration to the portion 22 when bending the blank 10 back upon itself as shown in FIG. 3. Additionally, it may also be convenient to permit the portion 22 to be slightly longer than the portion 20, for example, by an amount of about one twenty-fourth to one thirtysecond inch.

Of course, in lieu of the approximately oval shape of the blank 10 it is also possible to make the blank 10 of any other configuration, for example, of substantially rectangular configuration, in which case the occlusion clip portions 24 and 25 would be parallel to one another while the end portions 26 and 27 as well as the separating portion 18 would be at right angle thereto.

Referring now to FIGS. 5-11, the instrument for applying the occlusion clip according to this invention is in the form of an elongated tubular structure generally designated by reference numeral 30 (FIG. 5) which is provided at the left end thereof as viewed in FIG. 5 with jaws 32 and 34. In the illustrated embodiment, the jaw 34 is formed as an integral part of the tubular member adjacent the left end thereof as viewed in FIG. 5. On the other hand, the jaw 32 is pivotal about an axis 52 (FIGS. 7 and 11) between its open, clip receiving position (shown in full line in FIG. 8) and the clip-applying position shown in dash line in FIG. 8. Due to the slight eccentricity of the pivot axis 52, the closing movement of the jaw 32 is such that the free end of the jaws 34 and 32 will come into abutment against one another while also forming a narrow tapering space increasing in the direction toward the gripping portion generally designated by reference numeral 108. This particular closing movement assures that the free ends constituted by the connecting portions 26 and 27 are closed before the entire occlusion clip is more or less flattened out, thereby preventing a slipping off of the occlusion clip from the anatomical tubular structure such as a fallopian tube, when being applied and assuring other advantages as will be described more fully hereinafter by reference to FIGS. 15a and 15b.

On the side of the tubular member 50, opposite the jaws 34 and 32, i.e., on the right side as viewed in FIG. 5 is provided the handle generally designated by reference numeral 108 which includes an actuating member 54 in the form of a trigger, connected with the movable jaw 32 by way of the control linkage as will be described more fully hereinafter.

A separate tube 58 (FIG. 6) is provided on the inside of the tubular structure 50 for receiving and positioning an optical device of conventional construction, the front end of which is schematically indicated and designated in FIG. 6 by reference numeral 60. At its opposite end, the tube 58 is provided with a conventional eye piece 60' which may be adjustable if so desired. The viewing means 58, 60 and 60' permits the user of the instrument to view between the opened jaws as well as between the separated clamping portions 24 and 25 of the occlusion clip when in the initial position during the application as shown in FIG. 3, thus permitting a continuous viewing of the insertion of the instrument through the opening in the umbilicus and during the positioning thereof over the fallopian tube. The instrument also includes further means to produce a light beam 61 (FIG. 3) to illuminate the area between the jaws and in front thereof so as to facilitate the proper positioning and application of the occlusion clip over the anatomical tubular structures, especially the fallopian tube. These illuminating means may be of any conventional type, for example, in the form of another tube 62 which extends through the tube 50 and includes a light source, for instance in the form of a small lamp designated in FIG. 6 by reference numeral 64, by means of which a-beam of light 61 is produced to assure sufficient illumination to facilitate the positioning and application of the occlusion clip. However, in lieu of utilizing a light source 64 located at the end of the tube 62, it is preferable to use a light source in the form of conventional fiber-optics and constituted by the tube 62 with the primary light source for the fiber-optics located internally or preferably externally at any appropriate place on the instrument. Since such fiber-optical illuminating devices are known as such, a detailed description thereof is dispensed with herein.

As shown in FIG. 9, a pair of support projections 68 and 70 for the handle structure are secured to the tube 50 by conventional means. These supporting projections 68 and 70 are thereby located on both sides of an elongated recess 72 in the tube 50. The recess 72 slidably receives a slidable control member generally designated by reference numeral 74 and enables recipro cation thereof in the axial direction of the tube 50 between the two supporting projections 68 and 70. The slidable control member 74 includes a U-shaped upper body part formed by leg portions 76 and 76 connected by web portion 77 in such a manner that a substantially U-shaped recess 78 is formed. This recess 78 is so shaped as to receive the tubular member 62 for the illuminating device so that the slidable control member 74 is guided in its to and fro movement on the tube 62 when the control member is assembled in its position as shown in FIGS. 6 and 10. Additionally, the slidable control member 74 includes a pair of depending leg portions 80 and 82 spaced from one another to receive the body portion 84 of the trigger member 54. The body portion 84 is provided with a rectangular notch 86 to receive a pin 88 which extends across the U- shaped channel between the projecting leg portions 80 and 82. When the trigger member 54 is installed so that the pin 88 comes to lie in slot 86, the slidable control member 74 and trigger member 54 are in effect pivotally connected with each other. The trigger plate 84 is further provided with a corner 90 which, as shown in FIG. 6, is adapted to engage with the surface 70' of the supporting projection 70 so that in case of application of a force in the direction of arrow A (FIGS. 6 and 9), the corner 90 will abut at the surface 70' and thus constitutes a fulcrum about which the trigger member 54 will rotate in the counterclockwise direction, thereby imparting a sliding movement to the slidable control member 74 toward the left direction, as viewed in FIG. 6, which is made possible by the pivotal connection 86, 88, between these two parts. Thus, the camming action between corner 90 and surface translates the force A into sliding movements of the slidable control member 74.

A return spring 92 is interposed between the trigger plate 84 and the relatively stationary support member 70 and engages at its left end in a recess 94 provided in the trigger plate 84 and at the right end in the recess 96 provided in the supporting member 70.

The handle structure 108 further includes a pair of cover plates 98 and 100 (FIGS. 9 and 10), each provided with a recess 102 and 102', recess 102 being shown clearly in FIG. 9. The recesses 102 and 102 are intended to receive the leg portions and 82 of the slidable control member 74. Additionally, the cover members 98 and are provided with depending plate-like leg portions 104 and 106 which act as guide means for the trigger plate 84 when the parts are in the assembled position thereof as shown in FIG. 10. The handle assembly further includes a cover structure generally designated by reference numeral 108 which has a pair of parallel-spaced cover plate portions 110 and 110' connected by means of a rib 112 (FIG. 6). The cover plates 98 and 100 and the cover plate portions 110 and 110' as well as the rib 112 of the cover structure 108 are secured to the support members 68 and 70 by means, for example, of screws which extend through screw holes as indicated. However, any other suitable fastening means may also be used to hold the parts in their assembled position. The rib 112 is also held fast in its proper position by the two-point connection constituted by the pin-type pivotal connection 112 and the screw extending through aligned holes 110a and 112a and thehole 110a (not shown) in the cover portion 110'.

As shown in particular in FIGS. 7, 8 and 11, the jaw 34 is formed as an integral part of the exterior tube 50 adjacent its left end as viewed in FIGS. 5 and 6, and includes inwardly thereof lug portions 114 for pivotally supporting thereon by means of screws or the like the movable jaw 32. The lug portions 114 which are of approximately partially circular shape, provide guide surfaces 114' for the pivotal movement of the movable jaw member 32 which is also guided along the guide surfaces 1 14" (FIG. 8) constituted by the cut-out portions provided in the fixed jaw 34 to accommodate the side members 32' and 32" of the movable jaw 32. As shown particularly in FIG. 11, the fixed jaw 34, in addition to the nose-like indexing projection 38 is also provided with an aperture 35.

The movable jaw 32 includes a transverse end portion 116 and spaced side portions 118 and 120 each provided with bearing portions 122 and 124 at the side members 32' and 32" thereof and adapted to engage with the stationary bearing surfaces 114". The jaw 32 is thereby pivotally supported on the lug portions 114 by any suitable means such as screws. Below the bearing surfaces 122 and 124 the leg portions 32' and 32" are provided with the opposite aligning recesses 126 and 128 to receive a reciprocal, slidable control member generally designated by reference numeral 130 which is pivotally connected with the side members 32' and 32" by means of a pivot pin 132. The slidable control member 130 has an exterior configuration 134 at the bottom thereof to permit substantial alignment with and sliding movement along the inner surface of the outer tube 50. Additionally, the slidable control member 130 has an interior cylindrical recess 136 to provide for a substantially cylindrical aperture adjacent the jaw end of the tubular structure 50.

The slidable control member 130 is connected with the slidable control member '74 by means of a pair of elongated members 56 such as steel wires which are sufficiently stiff and rigid to cause the sliding control member 130 to partake in the reciprocation of the sliding control member 74 in response to actuation of the trigger 54.

In the illustrated embodiment, the illuminating device is in the form of an elongated tubular cable protective structure 62 for conducting by means of a cable disposed therewithin the supply voltage to a small electric bulb arranged at the front end thereof and indicated schematically by reference numeral 64 in FIG. 6. Appropriately the rear end of the cable protective structure or of the cable itself which extends through the tube 62, is bent downwardly as shown at 142 in FIG. 9 to be received between the side plates 110 and 112 so as to be protected thereby and held in position by means of a leaf spring 144 or the like. A power supply such as a battery can be connected to the lower end at 146 (FIG. 9).

However, as mentioned above, in lieu of the electrical connection extending through the tube 62, and the bulb 64, conventional fiber-optical means are preferably used to produce the desired illumination. The light source in the form of a suitable small incandescent high power lamp or the like may then be located in any suitable place, for example, externally of the tubular member 50, e.g., at the end of the portion 142, thereby obviating the need for the electrical cable and the bulb and the problem of replacing the same if wear occurs.

The optical device to be used with the instrument of the present invention, is in the form of an elongated structure and includes a number of optical lenses of conventional type as known in the art. Since the optical device, except for its particular location and association with the instrument of the present invention forms no part thereof, a detailed description is dispensed with herein.

As will be understood from the foregoing description of the instrument and occlusion clip of the present invention, the clip may be applied under direct continuous vision through the optical system during the opera tion. To that end, the movable jaw 32 is also provided with an aperture 33 so that continued viewing is made possible even after the free end of the movable jaw 32 abuts at the free end of the fixed jaw 34.

In actual use, the occlusion clip is positioned between the jaws as shown in FIG. 3 with the indexing projection 38 engaging in the indexing aperture 14 of the occlusion clip. After the introduction of the instrument through the umbilicus, it is properly positioned over the fallopian tube or the like, and with the aid of the illumination and the optical device, the location of the fallopian tube or other anatomical tubular structure becomes an easy matter for a trained surgeon. Since the fallopian tube can be observed directly through the opening 12 of the occlusion clip, i.e., through the spacing between the lateral clip portions 24 and 25, it is also easy to properly approach the anatomical tubular structure as well as to ascertain when the clip is in proper position relative thereto as shown in FIG. 12. In this position, the trigger 54 is actuated and the occlusion clip is closed on the tube 40 as shown in FIG. 13.

As can be seen from FIGS. 6, 8 and 11, the pivot point of the movable jaw 32 is slightly eccentric. This eccentricity in combination with the configuration of the portion 22 of the occlusion which, as mentioned hereinabovc may be slightly curved, provides for safe closing of the clip on the tube without crushing the tube to an extent that might otherwise cause damage or slipping off. This is a very important feature since the particular angulation of the jaws 32 and 34 and/or the height of the indexing tooth 38 permit that the separation of the occlusion clip arms, in the applied position, can be precisely predetermined. This is illustrated in FIGS. 15a and 15b, illustrating respectively somewhat schematic side elevational views of a clip in accordance with the present invention and of a clip of the prior art type, both when in the applied condition. In the clip 10 according to the present invention a predetermined separation or gap g exists between the two arm portions 20 and 22, when applied, within the area receiving the anatomical structure. This separation g, which can be precisely predetermined by the design of the instrument of this invention, i.e., by the eccentricity of the pivot point of the movable jaw 32 and/or the height of the indexing tooth 38, may be about 0.8 mm which has been determined optimum for certain applications, and can be varied in a simple manner, if necessary, to a value greater or smaller than 0.8 mm, for example, to 0.5 mm if the thickness of the anatomical structure or of its tissue walls so demands. This is very important because if a clip is closed fully flat, as is the case in the prior art, illustrated in FIG. 15b where similar reference numerals of the ZOO-series are applied to similar parts, the tissue is crushed, thereby becomes avascular, necroses and cuts through, resulting in fistule formation and failures. In contrast to the present invention the prior art offers no means of controlling the closure by simple means and therewith offers no means effectively avoiding such failures.

It should also be mentioned that the opening 12 in the clip 10 performs the important function in the applied condition. On the one hand it acts as a pressure relief means and on the other, assists in locking the clip in position on the anatomical structure. The openings 33 and 35 in jaws 32 and 34 perform similar functions during the application. These two functions are only schematically indicated in dash and dot lines in FIG. 15a, showing the possibility of parts of the tissues of the anatomical structures to pass through opening 12.

While the mutually facing surfaces of the two jaws 32 and 34 are flat and parallel to one another, it may also be advantageous to use a different arrangement. For example, the surfaces need not be parallel to one another but may form a slight angle therebetween by appropriate beveling of one or both jaws in such a manner that the separation g is, for example, about 0.8 mm on one side of the clip and say 0.5 mm, on the other side. Furthermore, the surfaces need not necessarily be flat for this purpose. However, it is quite apparent that the controlled closure" is still present in the non-parallel arrangement of the jaw surfaces, resulting in the avoidance of the failures of the prior art.

It will thus also be appreciated that slippage of the anatomical tubular structure during the clamping operation is prevented because of the herniation of the tissue during the earliest phase of closure and the particular closing movement of the jaws causing a near closing at the free ends of the jaw members 32 and 34 before final closing of the occlusion clip.

Though the occlusion clip of FIG. 1 is particularly desirable because of its two spaced clip portions 24 and 25, other types of occlusion clips having spaced clip members may be employed within the scope of this invention. A possible modification is shown in FIG. 14 which shows the front end of the instrument with an occlusion clip in the form of two completely separate narrow clip members 150 and 152 positioned relative to the jaws by means of individual indexing means 154 and 156. This will permit the application of entirely separate clips in one and the same operation.

Additionally, it is also possible within the scope of this invention to modify the occlusion clip shown in FIGS. 1 and 2 by leaving out the connecting portion 26 or 27 and/or the divider 18. In that case, an indexing means in one of the jaws may be in the form of a rib which extends transversely to the jaw adjacent the edge thereof operable to engage the edge of the connecting portion 26 left between the side members 24 and 25.

Furthermore, it is also possible to construct the instrument with jaws extending substantially perpendicular to the longitudinal axis of the tubular structure 50. In that case, it will only be necessary to include a prism or the like in the optical system to conduct the light rays around the then existing corner.

While the present invention finds particular application for purposes of sterlization in connection with the fallopian tubes, its application is not limited thereto. For example, in smaller versions, the present invention can also be used for ligations, for example, blood vessels or the like. In that case, the present invention still entails the advantage of requiring only a single application in lieu of the need for a repeated application of two or more clips.

Furthermore, through the use of the instrument through the umbilicus has been described, its use is not limited thereto but could be used equally successfully for sterlization after the delivery when the fallopian tubes can be made accessible by merely a small incision due to the enlarged condition of the uterus. Furthermore, in addition to the direct application to the fallopian tubes, the instrument may be used also for purposes of ligation of vas deferens in males. In all of these and other cover uses of the clip, the instrument can be simplified by omitting its optical system and/or its light source, thus resulting in a less costly instrument, still entailing the same advantage of controlled closure of the clip. Furthermore, the instrument is not limited to the particular actuating mechanism as shown and described but any other actuating mechanism may be equally used which converts the actuating movement into pivotal movement of the movable jaw. For example, in an instrument without optical system and light source, the tubular structure 50 can be omitted and the means for actuating the movable jaw can then be greatly modified and simplified in a conventional manner, substituting another type of actuating mechanism for the one illustrated herein.

Finally, the present invention is equally applicable under culdoscopy for application through a culdoscope or similar device.

Any suitable material having the requisite physical properties may be used for the occlusion clip in accordance with the present invention, tantalum being among the preferred materials.

While I have shown and described several embodiments in accordance with the present invention, it is understood that the same is not limited thereto but is susceptible of numerous changes and modifications as known to those skilled in the art, and I therefore do not wish to be limited to the details shown and described herein, but intend to cover all such changes and modifications as are encompassed by the scope of the appended claims.

What I claim is:

1. A method for mechanically applying an occlusion clip to an anatomical tubular structure which comprises the steps of securely mounting an occlusion clip onto a tubular instrument having clip-receiving jaws located near one end thereof and disposed in an open clip-receiving position, inserting said end of the tubular instrument having the jaws with the clip mounted thereon through an opening in an anatomical body and while viewing through an optical viewing means disposed near the other end of said tubular instrument and provided with illumination for illuminating the area of the jaws and the areas distally thereof, positioning the open jaws and the clip mounted thereon in a proper position over the anatomical tubularstructure and thereafter closing the clip to produce an occlusion in said anatomical structure.

2. The method of claim 1, werein viewing of the tubular structure is made through the tubular instrument and through the open jaws thereof.

3. A method according to claim 2, including the step of viewing through two spatially separated occlusion clip portions securely held in position on the jaws by complementary indexing means.

4. A method according to claim 3, including the step of applying the occlusion clip to a Fallopian tube through an opening made in the umbilicus.

5. A method according to claim 2, including the step of applying the occlusion clip to a Fallopian tube through an opening made in the umbilicus.

Citations de brevets
Brevet cité Date de dépôt Date de publication Déposant Titre
US190641 *8 mai 1877 Improvement in bale-ties
US1482290 *2 févr. 192129 janv. 1924Frank Elzi PeterBending tool
US2031682 *18 nov. 193225 févr. 1936Wappler Frederick CharlesMethod and means for electrosurgical severance of adhesions
US2599662 *2 févr. 195010 juin 1952Rosenbaum Randolph RCholedochoscope
US3613661 *20 déc. 196819 oct. 1971Nayan S ShahMechanically controlling flow through living body ducts
US3708149 *17 févr. 19712 janv. 1973Amp Domestic IncClosure device for closing flexible tubes
US3763860 *26 août 19719 oct. 1973H ClarkeLaparoscopy instruments and method for suturing and ligation
DE1091700B *6 août 195827 oct. 1960Gustav Mueller K GSteinzange fuer urologische Eingriffe
Citations hors brevets
Référence
1 *Fiber Optic Laparoscope, Brochure of American Cystoscope Makers, Inc., Pelham Manor, N.Y., February 1972.
Référencé par
Brevet citant Date de dépôt Date de publication Déposant Titre
US3924629 *29 nov. 19749 déc. 1975Akiyama TaichiroMethod for closing a cut end of a blood vessel
US4027510 *15 mai 19747 juin 1977Siegfried HiltebrandtForceps
US4064881 *1 juin 197627 déc. 1977Rocket Of London LimitedSurgical clip applicator
US4152920 *17 oct. 19778 mai 1979United States Surgical CorporationSystem for applying surgical clips
US4178920 *3 oct. 197718 déc. 1979American Hospital Supply CorporationUrological instrument with deflecting element
US4242902 *11 mai 19786 janv. 1981United States Surgical CorporationSurgical clip applicator
US4570633 *15 avr. 198518 févr. 1986Ethicon, Inc.Surgical clip applier instrument adapter jaws
US4579118 *1 juin 19831 avr. 1986Ethicon, Inc.Hemostatic clip with penetration means
US4616651 *22 août 198514 oct. 1986Ethicon, Inc.Surgical clip applier instrument adapter jaws
US4635634 *12 juil. 198513 janv. 1987Santos Manuel VSurgical clip applicator system
US4813407 *30 juil. 198621 mars 1989Vogen Kenneth WSesamoid bone clamp
US5062846 *17 oct. 19895 nov. 1991Edward Weck IncorporatedPenetrating plastic ligating clip
US5300081 *9 oct. 19925 avr. 1994United States Surgical CorporationSurgical clip applier having clip advancement control
US5373840 *2 oct. 199220 déc. 1994Knighton; David R.Endoscope and method for vein removal
US5382254 *30 oct. 199217 janv. 1995United States Surgical CorporationActuating handle for surgical instruments
US5382255 *8 janv. 199317 janv. 1995United States Surgical CorporationApparatus and method for assembly of surgical instruments
US5383881 *22 sept. 199324 janv. 1995United States Surgical CorporationSafety device for use with endoscopic instrumentation
US5441509 *9 nov. 199415 août 1995Minnesota Mining And Manufacturing CompanyVessel clips
US5445167 *28 sept. 199229 août 1995Yoon; InbaeMethods of applying surgical chips and suture tie devices to bodily tissue during endoscopic procedures
US5487746 *23 nov. 199430 janv. 1996Yu; George W.Surgical clip having a longitudinal opening through which clamped tissue protrudes
US5620452 *22 déc. 199415 avr. 1997Yoon; InbaeSurgical clip with ductile tissue penetrating members
US5665100 *20 janv. 19959 sept. 1997Yoon; InbaeMultifunctional instrument with interchangeable operating units for performing endoscopic procedures
US5707380 *23 juil. 199613 janv. 1998United States Surgical CorporationAnastomosis instrument and method
US5707389 *7 juin 199513 janv. 1998Baxter International Inc.Side branch occlusion catheter device having integrated endoscope for performing endoscopically visualized occlusion of the side branches of an anatomical passageway
US5772576 *11 déc. 199530 juin 1998Embro Vascular L.L.C.For removing cylindrical tissue structures from human or animal bodies
US5797939 *27 déc. 199625 août 1998Yoon; InbaeEndoscopic scissors with longitudinal operating channel
US5797958 *4 déc. 199625 août 1998Yoon; InbaeEndoscopic grasping instrument with scissors
US5810711 *7 mai 199622 sept. 1998Hafslund Nycomed Pharma AktiengesellschaftDevice for use in endoscopy and laparoscopy
US5833696 *3 oct. 199610 nov. 1998United States Surgical CorporationTo body tissue
US5947970 *23 avr. 19987 sept. 1999Synthes (Usa)Endoscopic bone plate positioning device
US5947994 *8 août 19977 sept. 1999Baxter International Inc.Endoscopically-assisted device for endoluminal occlusion of anatomical passageway side branches
US5957927 *24 févr. 199828 sept. 1999Synthes (Usa)Bone fixation device introducer
US5984939 *1 mai 199716 nov. 1999Yoon; InbaeMultifunctional grasping instrument with cutting member and operating channel for use in endoscopic and non-endoscopic procedures
US6024748 *17 juin 199715 févr. 2000United States Surgical CorporationSingleshot anastomosis instrument with detachable loading unit and method
US6071232 *29 juin 19986 juin 2000Embro Vascular L.L.C.Apparatus for vein removal
US6086586 *14 sept. 199811 juil. 2000Enable Medical CorporationBipolar tissue grasping apparatus and tissue welding method
US64284685 juin 20006 août 2002Cardiothoracic Systems, Inc.Apparatus and method for vein removal
US650620014 mars 200014 janv. 2003Origin Medsystems, Inc.Tissue separation cannula and method
US651149417 nov. 200028 janv. 2003Embro CorporationVein harvesting system and method
US655831317 nov. 20006 mai 2003Embro CorporationVein harvesting system and method
US670598618 mars 200316 mars 2004Embro CorporationVein harvesting system and method
US67266978 juil. 200227 avr. 2004United States Surgical CorporationAnastomosis instrument and method
US676959431 mai 20023 août 2004Tyco Healthcare Group, LpEnd-to-end anastomosis instrument and method for performing same
US70014049 janv. 200321 févr. 2006Origin Medsystems, Inc.Tissue separation cannula and method
US705951019 nov. 200413 juin 2006Tyco Healthcare Group LpEnd-to-end anastomosis instrument and method for performing same
US70668757 juin 200227 juin 2006Cardio Thoracic Systems, Inc.Apparatus and method for vein removal
US716915818 oct. 200130 janv. 2007Tyco Healthcare Group LpAnastomosis instrument and method for performing same
US71951421 mai 200627 mars 2007Tyco Healthcare Group LpEnd-to-end anastomosis instrument and method for performing same
US720484313 mars 200317 avr. 2007United States Surgical CorporationAnastomosis instrument and method for performing same
US721104017 févr. 20041 mai 2007Embro CorporationVein harvesting system and method
US72141806 janv. 20038 mai 2007Origin Medsystems, Inc.Method for cardiac restraint
US722327318 janv. 200129 mai 2007Tyco Healthcare Group LpAnastomosis instrument and method for performing same
US726458717 janv. 20034 sept. 2007Origin Medsystems, Inc.Endoscopic subxiphoid surgical procedures
US728809618 févr. 200330 oct. 2007Origin Medsystems, Inc.Apparatus for placement of cardiac defibrillator and pacer
US732299418 août 200329 janv. 2008United States Surgical CorporationAnastomosis instrument and method
US73844238 oct. 200210 juin 2008Origin Medsystems, Inc.Tissue dissection method
US73987819 août 200015 juil. 2008Maquet Cardiovascular, LlcMethod for subxiphoid endoscopic access
US749785729 avr. 20033 mars 2009Medtronic, Inc.Endocardial dispersive electrode for use with a monopolar RF ablation pen
US752634229 oct. 200328 avr. 2009Maquet Cardiovascular LlcApparatus for endoscopic cardiac mapping and lead placement
US759769810 juil. 20036 oct. 2009Maquet Cardiovascular LlcApparatus and method for endoscopic encirclement of pulmonary veins for epicardial ablation
US76353855 mai 200622 déc. 2009Keith MillimanAnastomosis instrument and method for performing same
US764528526 mai 200412 janv. 2010Idx Medical, LtdApparatus and methods for occluding a hollow anatomical structure
US77439585 mai 200629 juin 2010Tyco Healthcare Group LpEnd-to-end anastomosis instrument and method for performing same
US780690424 févr. 20045 oct. 2010Integrated Vascular Systems, Inc.Closure device
US780691031 juil. 20065 oct. 2010Abbott LaboratoriesMulti-element biased suture clip
US781989518 avr. 200626 oct. 2010Integrated Vascular Systems, Inc.Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US78288174 août 20059 nov. 2010Integrated Vascular Systems, Inc.Apparatus and methods for delivering a closure device
US784150218 déc. 200730 nov. 2010Abbott LaboratoriesModular clip applier
US784206830 nov. 200130 nov. 2010Integrated Vascular Systems, Inc.Apparatus and methods for providing tactile feedback while delivering a closure device
US78507094 juin 200314 déc. 2010Abbott Vascular Inc.Blood vessel closure clip and delivery device
US785079712 mars 200914 déc. 2010Integrated Vascular Systems, Inc.Methods for manufacturing a clip and clip
US785481017 déc. 200321 déc. 2010Integrated Vascular Systems, Inc.Methods for manufacturing a clip and clip
US78578281 févr. 200528 déc. 2010Integrated Vascular Systems, Inc.Clip applier and methods of use
US786716312 déc. 200811 janv. 2011Maquet Cardiovascular LlcInstrument and method for remotely manipulating a tissue structure
US78672498 août 200311 janv. 2011Integrated Vascular Systems, Inc.Clip applier and methods of use
US78714092 févr. 200918 janv. 2011Medtronic, Inc.Endocardial dispersive electrode for use with a monopolar RF ablation pen
US78790719 mai 20031 févr. 2011Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US78875559 juil. 200315 févr. 2011Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US788756314 juin 200515 févr. 2011Abbott Vascular Inc.Surgical staple
US79014202 nov. 20068 mars 2011University Of MassachusettsTissue clamp
US79014283 oct. 20028 mars 2011Integrated Vascular Systems, Inc.Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US790590030 janv. 200315 mars 2011Integrated Vascular Systems, Inc.Clip applier and methods of use
US791887318 sept. 20065 avr. 2011Abbott Vascular Inc.Surgical staple
US79311831 juin 201026 avr. 2011Tyco Healthcare Group LpEnd-to-end anastomosis instrument and method for performing same
US793166917 mai 200226 avr. 2011Integrated Vascular Systems, Inc.Integrated vascular device with puncture site closure component and sealant and methods of use
US79388425 oct. 199910 mai 2011Maquet Cardiovascular LlcTissue dissector apparatus
US795955330 sept. 200814 juin 2011Embro CorporationVein harvesting system and method
US797226521 juil. 20045 juil. 2011Maquet Cardiovascular, LlcDevice and method for remote vessel ligation
US798113321 déc. 200719 juil. 2011Maquet Cardiovascular, LlcTissue dissection method
US80075128 oct. 200330 août 2011Integrated Vascular Systems, Inc.Plunger apparatus and methods for delivering a closure device
US804808624 févr. 20051 nov. 2011Femasys Inc.Methods and devices for conduit occlusion
US804810129 sept. 20081 nov. 2011Femasys Inc.Methods and devices for conduit occlusion
US80481084 févr. 20091 nov. 2011Abbott Vascular Inc.Vascular closure methods and apparatuses
US805266929 sept. 20088 nov. 2011Femasys Inc.Methods and devices for delivery of compositions to conduits
US805270015 févr. 20088 nov. 2011University Of MassachusettsTissue clamp
US810942715 avr. 20117 févr. 2012Tyco Healthcare Group LpEnd-to end anastomosis instrument and method for performing same
US812864419 sept. 20036 mars 2012Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US81824974 oct. 201022 mai 2012Integrated Vascular Systems, Inc.Closure device
US819245913 déc. 20105 juin 2012Abbott Vascular Inc.Blood vessel closure clip and delivery device
US819246110 sept. 20095 juin 2012Cook Medical Technologies LlcMethods for facilitating closure of a bodily opening using one or more tacking devices
US820228312 nov. 201019 juin 2012Integrated Vascular Systems, Inc.Methods for manufacturing a clip and clip
US820229320 juin 200819 juin 2012Integrated Vascular Systems, Inc.Clip applier and methods of use
US820229420 déc. 201019 juin 2012Integrated Vascular Systems, Inc.Clip applier and methods of use
US822668125 juin 200724 juil. 2012Abbott LaboratoriesMethods, devices, and apparatus for managing access through tissue
US823602627 mars 20067 août 2012Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US82412104 janv. 200814 août 2012Maquet Cardiovascular LlcVessel retractor
US825739015 févr. 20074 sept. 2012Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US830362415 mars 20106 nov. 2012Abbott Cardiovascular Systems, Inc.Bioabsorbable plug
US831349728 juin 200620 nov. 2012Abbott LaboratoriesClip applier and methods of use
US831685317 juil. 200927 nov. 2012Femasys Inc.Method and devices for conduit occlusion
US831685431 oct. 201127 nov. 2012Femasys Inc.Methods and devices for conduit occlusion
US83233129 juin 20094 déc. 2012Abbott LaboratoriesClosure device
US832419331 oct. 20114 déc. 2012Femasys Inc.Methods and devices for delivery of compositions to conduits
US833655231 oct. 201125 déc. 2012Femasys Inc.Methods and devices for conduit occlusion
US83986562 mars 201119 mars 2013Integrated Vascular Systems, Inc.Clip applier and methods of use
US839867629 oct. 200919 mars 2013Abbott Vascular Inc.Closure device
US846033122 avr. 201111 juin 2013Maquet Cardiovascular, LlcTissue dissector apparatus and method
US84699954 juin 201225 juin 2013Abbott Vascular Inc.Blood vessel closure clip and delivery device
US848069616 juin 20059 juil. 2013Medtronic, Inc.Minimally invasive coring vein harvester
US848609211 mars 200916 juil. 2013Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US84861081 févr. 200616 juil. 2013Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US849161015 déc. 200923 juil. 2013Cook Medical Technologies LlcClip devices and methods of delivery and deployment
US85007607 déc. 20096 août 2013Cook Medical Technologies LlcRetractable tacking device
US851805713 sept. 201227 août 2013Abbott LaboratoriesClip applier and methods of use
US85295876 juin 201210 sept. 2013Integrated Vascular Systems, Inc.Methods of use of a clip applier
US855113928 nov. 20078 oct. 2013Cook Medical Technologies LlcVisceral anchors for purse-string closure of perforations
US855693028 juin 200615 oct. 2013Abbott LaboratoriesVessel closure device
US857993224 févr. 200412 nov. 2013Integrated Vascular Systems, Inc.Sheath apparatus and methods for delivering a closure device
US858571826 août 201119 nov. 2013Aesculap AgCartridge with a plurality of C-shaped ligature clips
US858583618 juin 201219 nov. 2013Integrated Vascular Systems, Inc.Methods for manufacturing a clip and clip
US859076024 mai 200526 nov. 2013Abbott Vascular Inc.Surgical stapler
US859732529 nov. 20103 déc. 2013Integrated Vascular Systems, Inc.Apparatus and methods for providing tactile feedback while delivering a closure device
US86031164 août 201010 déc. 2013Abbott Cardiovascular Systems, Inc.Closure device with long tines
US86031363 mai 200710 déc. 2013Integrated Vascular Systems, Inc.Apparatus and methods for providing tactile feedback while delivering a closure device
US861718415 févr. 201131 déc. 2013Abbott Cardiovascular Systems, Inc.Vessel closure system
US863675411 nov. 201028 janv. 2014Atricure, Inc.Clip applicator
US86473682 avr. 201011 févr. 2014Cook Medical Technologies LlcTissue anchors and medical devices for rapid deployment of tissue anchors
US86578528 mars 201325 févr. 2014Abbott Vascular Inc.Closure device
US86729536 juin 201118 mars 2014Abbott LaboratoriesTissue closure system and methods of use
US869091031 mars 20068 avr. 2014Integrated Vascular Systems, Inc.Closure device and methods for making and using them
US869560624 nov. 201215 avr. 2014Femasys Inc.Methods and devices for conduit occlusion
US872690625 nov. 201220 mai 2014Femasys Inc.Methods and devices for conduit occlusion
US872811918 févr. 201120 mai 2014Abbott Vascular Inc.Surgical staple
US874093722 mai 20083 juin 2014Cook Medical Technologies LlcSuture lock
US8752214 *27 août 201017 juin 2014Miguel MaldonadoPositioning brace for a kneepad
US8753356 *9 oct. 200717 juin 2014Ethicon Endo-Surgery, Inc.Surgical clip applier methods
US875839627 avr. 200624 juin 2014Integrated Vascular Systems, Inc.Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US87583987 sept. 200724 juin 2014Integrated Vascular Systems, Inc.Apparatus and method for delivering a closure element
US87583992 août 201024 juin 2014Abbott Cardiovascular Systems, Inc.Expandable bioabsorbable plug apparatus and method
US87584008 nov. 201024 juin 2014Integrated Vascular Systems, Inc.Closure system and methods of use
US876476827 août 20091 juil. 2014Cook Medical Technologies LlcStapling device for closing perforations
US20080004639 *14 sept. 20073 janv. 2008Ethicon Endo-Surgery, Inc.Force limiting mechanism for medical instrument
US20080027465 *9 oct. 200731 janv. 2008Ethicon Endo-Surgery, Inc.Surgical clip applier methods
USRE36043 *11 janv. 199612 janv. 1999Embro Vascular, L.L.C.Endoscope and method for vein removal
DE2625425A1 *5 juin 197616 déc. 1976Rocket Of London LtdHaltevorrichtung fuer operationsclips
DE2741910A1 *17 sept. 197723 mars 1978Kli IncChirurgisches abbindeinstrument
DE2838925A1 *7 sept. 197820 mars 1980Hug Gerhard GmbhZange zum setzen eines clip auf leitungsbahnen in einem menschlichen oder tierischen organismus und clip zur verwendung in verbindung mit dieser zange
EP0559417A1 *1 mars 19938 sept. 1993Ethicon Inc.Endoscopic suture clip
EP0567965A2 *26 avr. 19933 nov. 1993United States Surgical CorporationVessel clips
WO1996015726A1 *21 nov. 199530 mai 1996H Logan HoltgreweA surgical clip having a longitudinal opening through which clamped tissue protrudes
WO1998018389A1 *22 sept. 19977 mai 1998Alan A ConlanSurgical vessel clips and methods for closing vessels
Classifications
Classification aux États-Unis128/831, 24/30.50W, 72/409.1, 606/158, 600/104, 24/23.00W
Classification internationaleF02B3/06, A61B17/32, A61B17/122, A61B1/303, A61F6/20
Classification coopérativeA61B1/303, F02B3/06, A61B17/32, A61B17/122, A61F6/204
Classification européenneA61B1/303, A61F6/20B2, A61B17/122
Événements juridiques
DateCodeÉvénementDescription
5 déc. 1983AS01Change of name
Owner name: COOPER MEDICAL CORPORATION
Owner name: COOPER MEDICAL DEVICES CORPORATION
Effective date: 19820730
5 déc. 1983AS03Merger
Owner name: COOPER MEDICAL DEVICES CORPORATION A DE CORP.
Effective date: 19800625
Owner name: KLI, INC. A PA CORP.
5 déc. 1983AS02Assignment of assignor's interest
Owner name: CABOT MEDICAL CORPORATION, 2021 CABOT BLVD., WEST,
Owner name: COOPER LABORATORIES, INC.
Owner name: COOPER MEDICAL CORPORATION
Effective date: 19830418
5 déc. 1983ASAssignment
Owner name: CABOT MEDICAL CORPORATION, 2021 CABOT BLVD., WEST,
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:COOPER MEDICAL CORPORATION;COOPER LABORATORIES, INC.;REEL/FRAME:004235/0348
Effective date: 19830418
Owner name: COOPER MEDICAL CORPORATION
Free format text: CHANGE OF NAME;ASSIGNOR:COOPER MEDICAL DEVICES CORPORATION;REEL/FRAME:004213/0338
Effective date: 19820730
Owner name: COOPER MEDICAL DEVICES CORPORATION
Free format text: MERGER;ASSIGNOR:KLI, INC. A CORP. OF PA;REEL/FRAME:004211/0396
Owner name: COOPER MEDICAL DEVICES CORPORATION A DE CORP.
Free format text: MERGER;ASSIGNOR:KLI, INC. A PA CORP.;REEL/FRAME:004213/0341
Effective date: 19800625
Owner name: COOPER MEDICAL DEVICES CORPORATION, 100 WEST TENTH
Free format text: MERGER;ASSIGNOR:KLI, INC., INTO;REEL/FRAME:004210/0072
Effective date: 19830620