US3858580A - Intravenous container mixing assembly - Google Patents
Intravenous container mixing assembly Download PDFInfo
- Publication number
- US3858580A US3858580A US30278372A US3858580A US 3858580 A US3858580 A US 3858580A US 30278372 A US30278372 A US 30278372A US 3858580 A US3858580 A US 3858580A
- Authority
- US
- United States
- Prior art keywords
- vial
- spike
- fluid
- drip meter
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1407—Infusion of two or more substances
- A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2041—Separating means having removable plugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2075—Venting means for external venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2079—Filtering means
- A61J1/2082—Filtering means for gas filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
- A61M2005/1623—Details of air intake
Definitions
- ABSTRACT A device for the mixing and administration of intravekat fluid comprising a cylindrical vial having an open end and a closed end, an inwardly extending integral annular ring within the vial and forming part of the walls of the vial intermediate said open and closed ends. A tippable center septum seals on the annular ring. An imperforate stopper is provided in the open end of the vial.
- the vial is adapted to contain two liquids or a liquid and a dry material in separated state.
- a non-opaque drip meter having a fluid outlet at one end and a fluid inlet is provided, the inlet comprising a tubular member terminating within the drip meter whereby drops can be visually observed at the end of the tubular member through the drip meter.
- Extending from the drip meter is a solid or hollow elongated rigid spike having an enlarged base adjacent the drip meter, the spike terminating in a point at its other end.
- a filtered air inlet is positioned in proximity to the base of the spike, a passage and filter are associated with the spike or base for admitting filtered air into the vial.
- a fluid passage runs through the base and has one end adjacent the spike at the exterior of the base and the other end communicates with the tubular member. The spike is adapted to puncture the stopper and tip the septum whereby the contents of the vial can be mixed without contamination from the exterior and the fluid contents of the vial can flow through the fluid passage and the drip meter while filtered air passes into the vial.
- the present invention is basically concerned with eliminating these problems and hazards by providing a closed system in which the solid medicament and its diluent can be packaged under strict sterile conditions at the factory, and reconstituted at the time of use without the necessity of the medicament becoming contaminated during a transfer operation. It is the art of administering intravenous solutions.
- this invention comprises a novel device for the mixing and administration of intravenous fluid comprising a cylindrical vial having an open end and a closed end, an inwardly extending integral annular ring within said vial and forming part of the walls of said vial intermediate said open and closed ends, a tippable center septum sealing on said annular ring, an imperforate stopper in said open end, said vial being adapted to contain two liquids or a liquid and a dry material in separated state, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter a solid or hollow elongated rigid spike having an enlarged base adjacent said drip meter, said spike terminating in a point at its other end, a filtered air inlet positioned in proximity to the base of said spike, means
- Another object of this invention is to provide a novel device for the packaging and administration of medicament for intravenous use which during storage is maintained in separated condition, viz, two liquids or a liquid and a dry material.
- FIG. 1 shows one embodiment of the drip meter and spike of this invention.
- FIG. 2 is a top viewof the device of FIG. 1.
- FIG. 3 is a bottom view of the device of FIG. 1.
- FIG. 4 shows, in side sectional view, one embodiment of the vial, center septum and end stopper of this invention.
- FIG. 5 is a plan view of the end stopper of the vial of FIG. 4.
- FIG. 6 shows, in sectional view, the parts of FIGS. 1-5 in partially assembled condition.
- FIG. 7 is a sectional view of the parts of FIG. 1-5 in fully assembled condition.
- FIG. 8 is a sectional view of another embodiment of this invention.
- the cylindrical vial 10 has an open end 12 and a closed end 14.
- the center septum 16 is positioned just above and abuts the integral annular ring 18.
- chamber 20 which contains a dry or lyophilized medicament 22.
- the septum 16 has four sealing rings 24, 26, 28 and 30 which form a seal on the inside walls of the vial 10.
- a chamber 32 for liquid or diluent 34 is provided between septum 16 and the end stopper 36.
- the end stopper 36 unlike septum I6, is non-reciprocating; that is, it is not slidable downwardly within vial 10, such movement being prevented by shoulders 38 which overlay and may seal upon the ends of vial10.
- the drip meter 40 has an outlet 42 provided with tubing 44 normally intended to carry the intravenous solution to the patient in conventional fashion.
- the drip meter 40 is normally non-opaque; that is, transparent or translucent so that drops of fluid may be observed and/or counted.
- the drip meter 40 has a fluid inlet comprising a tubular member 46 which terminates within the non-opaque drip meter.
- the rigid spike 48 is solid and hasan enlarged base 50 adjacent the drip meter 40.
- the spike 48 has a point 52 at one end.
- the opening 54 in base 50 communicates with air opening 56.
- the opening 56 is normally provided with cotton 58 or other filtering material intended to entrap any airborne particulate matter or bacteria in the entering air.
- the fluid passage 60 runs through the base 50 and functions as a downcomer for fluid. The lower end of passage 60 communicates with the tubular member 46.
- FIGS. 1 and 2 are made up beginning as in FIG. 6 and concluding as in FIG. 7 whereby the spike 48 tips the center septum 16, allowing mixing and reconstitution to occur.
- the flange 62 is brought up flush with the exterior of stopper 36 so that passage 60 is in fluid communication with the fluid contents of the vial 10.
- the spike 48 is long enough to reach and tip septum 16 at or prior to the time the flange 62 is flush with stopper 36.
- FIG. 8 shows another embodiment of this invention wherein the via] 64, annular ring 66, center septum 68 and end stopper 70 have the structure previously described.
- the drip meter 72 has an outlet 74 provided with tubing 76 and a fluid inlet comprising the tubular member 78.
- the rigid spike 80 is hollow and has a central opening 82 and a scarf or point 84 at one end.
- the opening 82 communicates with the air opening 86.
- the fluid passage 88 runs through the base 90 and communicates with tubular member 78.
- the point 84 is above the initial fluid level in the vial 64 when the parts are fully assembled. Thus, the entering air is discharged at point 84, above the fluid level in the vial.
- the septum 68 has a centrally domed surface 92 which facilitates the tipping of the septum by the spike 80.
- the domed surface is particularly desirable where the spike is centrally disposed in the vial rather than offset from the centerline of the vial as shown in the drawings.
- the tipping action afforded by the annular ring and septum allows the chamber adjacent the closed end of the vial to be smaller than the diameter of the septum. In other words, by providing for tipping action, this chamber can be substantially reduced in length since it does not receive the septum in length. This function reduces glass usage and saves space.
- the end stopper has a circular area bridged by a thin imperforate diaphragm 94.
- the diaphragm is readily punctured by the point of the spike.
- a novel device for the administration of intravenous fluids which comprises a cylindrical fluid container having an open end and a closed end, an imperforate stopper in said open end, an annular inwardly projecting ring within said container, a tippable center septum abutting said ring, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter an elongated rigid spike having an enlarged base adjacent said drip meter, said spike terminating in a point at its other end, said other end extending into said container, a filtered air inlet positioned in proximity to the base of said spike, means for admitting filtered air into said container, a fluid passage running through said base and having one end adjacent the spike at the exterior of said base so that essentially all of the fluid within said container can drain out by gravity through said fluid passage
- a novel device for the administration of intravenous fluids which comprises a cylindrical fluid vial having an open end and a closed end, an imperforate stopper in said open end, an annular inwardly projecting ring within said vial, a tippable center septum abutting said ring, a non-opaque drip meter having a fluid outlet at one end and a fluid inlet, said inlet comprising a tubular member terminating within said drip meter whereby'drops can be visually observed at the end of said tubular member through said drip meter, extending from said drip meter an elongated rigid solid spike having an enlarged base adjacent said drip meter, said solid spike terminating in a point at its other end, said other end extending into said container, a filtered air inlet positioned in proximity to the base of said solid spike, means for admitting filtered air into said container, a fluid passage running through said base and having one end adjacent the solid spike at the exterior of said base so that essentially all of the fluid within said container can drain out
Abstract
Description
Claims (9)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05302783 US3858580A (en) | 1969-06-04 | 1972-11-01 | Intravenous container mixing assembly |
CA161,659A CA1001513A (en) | 1972-11-01 | 1973-01-19 | Intravenous container mixing assembly |
US05/587,151 USRE29062E (en) | 1972-11-01 | 1975-06-16 | Intravenous container mixing assembly |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83031169A | 1969-06-04 | 1969-06-04 | |
US19588671A | 1971-11-04 | 1971-11-04 | |
US05302783 US3858580A (en) | 1969-06-04 | 1972-11-01 | Intravenous container mixing assembly |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US05/587,151 Reissue USRE29062E (en) | 1972-11-01 | 1975-06-16 | Intravenous container mixing assembly |
Publications (1)
Publication Number | Publication Date |
---|---|
US3858580A true US3858580A (en) | 1975-01-07 |
Family
ID=23169189
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US05302783 Expired - Lifetime US3858580A (en) | 1969-06-04 | 1972-11-01 | Intravenous container mixing assembly |
US05/587,151 Expired - Lifetime USRE29062E (en) | 1972-11-01 | 1975-06-16 | Intravenous container mixing assembly |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US05/587,151 Expired - Lifetime USRE29062E (en) | 1972-11-01 | 1975-06-16 | Intravenous container mixing assembly |
Country Status (2)
Country | Link |
---|---|
US (2) | US3858580A (en) |
CA (1) | CA1001513A (en) |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988002161A1 (en) * | 1985-07-18 | 1988-03-24 | Carol Smith | Method and apparatus for injection of pharmaceuticals |
DE3736487C1 (en) * | 1987-10-28 | 1988-11-10 | Braun Melsungen Ag | Flexible multi-chamber container |
US4979941A (en) * | 1989-12-05 | 1990-12-25 | International Medication Systems, Limited | Device suitable for mixing medication |
US5226878A (en) * | 1992-01-10 | 1993-07-13 | Whitaker Designs, Inc. | Two-container system for mixing medicament with diluent including safety wand to protect against improper titration |
US5358501A (en) * | 1989-11-13 | 1994-10-25 | Becton Dickinson France S.A. | Storage bottle containing a constituent of a medicinal solution |
WO1998056438A1 (en) * | 1997-06-10 | 1998-12-17 | Astra Pharmaceuticals Pty. Ltd. | Prefilled container |
US6065828A (en) * | 1997-02-26 | 2000-05-23 | Hewlett-Packard Company | Selectable mixing of inkjet ink components |
US6481435B2 (en) * | 1998-10-17 | 2002-11-19 | Boehringer Ingelheim Pharma Kg | Closure-cap and container as a two-chamber cartridge for nebulizers for producing aerosols and active substance formulations, suitable for storage |
US20030153865A1 (en) * | 2002-02-11 | 2003-08-14 | Brian Connell | Dialysis connector and cap having an integral disinfectant |
US20030181849A1 (en) * | 2002-02-11 | 2003-09-25 | Castellanos Rafael A. | Enclosure with cam action snap release |
WO2004052430A2 (en) * | 2002-12-09 | 2004-06-24 | Zi Medical Plc | Infusion apparatus for infusion bags |
US20050241634A1 (en) * | 1996-04-19 | 2005-11-03 | Dieter Hochrainer | Two-chamber cartridge for propellant-free metering aerosols |
US20090275881A1 (en) * | 2008-05-02 | 2009-11-05 | Baxter International Inc. | Optimizing therapy outcomes for peritoneal dialysis |
US20100130919A1 (en) * | 2008-11-21 | 2010-05-27 | Baxter International Inc. | Systems and methods for removing air from the patient's peritoneal cavity |
US20100130918A1 (en) * | 2008-11-21 | 2010-05-27 | Baxter International Inc. | Systems and methods for removing air from supply containers and associated fill tubing |
FR2941371A1 (en) * | 2009-01-28 | 2010-07-30 | Alaxia | DEVICE FOR THE EXTENDED PREPARATION OF MEDICINAL PREPARATIONS |
US20100198138A1 (en) * | 2009-01-30 | 2010-08-05 | Baxter International Inc. | Transfer sets for therapy optimization |
US8882700B2 (en) | 2008-05-02 | 2014-11-11 | Baxter International Inc. | Smart patient transfer set for peritoneal dialysis |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
EP3139983A2 (en) * | 2014-05-07 | 2017-03-15 | Boehringer Ingelheim International GmbH | Container, indicator device, and nebulizer |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
GB2563867A (en) * | 2017-06-28 | 2019-01-02 | Ndm Technologies Ltd | Drug delivery apparatus |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6070761A (en) | 1997-08-22 | 2000-06-06 | Deka Products Limited Partnership | Vial loading method and apparatus for intelligent admixture and delivery of intravenous drugs |
FR2798649B1 (en) * | 1999-09-22 | 2001-12-07 | Oreal | DEVICE FOR THE SEPARATE PACKAGING OF TWO COMPONENTS, THEIR MIXTURE AND THE DISTRIBUTION OF THE MIXTURE THUS OBTAINED |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2111985A (en) * | 1933-03-28 | 1938-03-22 | Kimble Glass Co | Container |
US2232978A (en) * | 1939-12-04 | 1941-02-25 | Arthur E Smith | Ampule opener |
US2377274A (en) * | 1943-02-20 | 1945-05-29 | Arthur E Smith | Ampule |
US2610628A (en) * | 1950-05-09 | 1952-09-16 | Compule Corp | Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures |
US3467097A (en) * | 1965-07-06 | 1969-09-16 | V O M Corp | Dual medicinal vial |
US3494359A (en) * | 1969-03-17 | 1970-02-10 | Silver Jules | Two compartment syringe with a single barrel |
US3670728A (en) * | 1970-06-01 | 1972-06-20 | Cutter Lab | Apparatus for intravenous administration of a fluid from a dual-chamber flask having an internal upset-table septum normally separating two axially-in-line chambers and having a pierceable end stopper |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1071557A (en) * | 1953-02-27 | 1954-09-02 | Further training in blood and drug solution infusion devices | |
FR66274E (en) * | 1954-05-06 | 1956-06-28 | Instrumentation Medico Chirurg | Device for sampling liquids from sealed vials |
FR1225859A (en) * | 1959-02-20 | 1960-07-06 | Pharmacotechnie Ind | Device for injecting medicated solutions |
-
1972
- 1972-11-01 US US05302783 patent/US3858580A/en not_active Expired - Lifetime
-
1973
- 1973-01-19 CA CA161,659A patent/CA1001513A/en not_active Expired
-
1975
- 1975-06-16 US US05/587,151 patent/USRE29062E/en not_active Expired - Lifetime
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2111985A (en) * | 1933-03-28 | 1938-03-22 | Kimble Glass Co | Container |
US2232978A (en) * | 1939-12-04 | 1941-02-25 | Arthur E Smith | Ampule opener |
US2377274A (en) * | 1943-02-20 | 1945-05-29 | Arthur E Smith | Ampule |
US2610628A (en) * | 1950-05-09 | 1952-09-16 | Compule Corp | Plural-compartment admixing vial for segregated storage of ingredients of solutions and liquid mixtures |
US3467097A (en) * | 1965-07-06 | 1969-09-16 | V O M Corp | Dual medicinal vial |
US3494359A (en) * | 1969-03-17 | 1970-02-10 | Silver Jules | Two compartment syringe with a single barrel |
US3670728A (en) * | 1970-06-01 | 1972-06-20 | Cutter Lab | Apparatus for intravenous administration of a fluid from a dual-chamber flask having an internal upset-table septum normally separating two axially-in-line chambers and having a pierceable end stopper |
Cited By (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988002161A1 (en) * | 1985-07-18 | 1988-03-24 | Carol Smith | Method and apparatus for injection of pharmaceuticals |
DE3736487C1 (en) * | 1987-10-28 | 1988-11-10 | Braun Melsungen Ag | Flexible multi-chamber container |
US5358501A (en) * | 1989-11-13 | 1994-10-25 | Becton Dickinson France S.A. | Storage bottle containing a constituent of a medicinal solution |
US4979941A (en) * | 1989-12-05 | 1990-12-25 | International Medication Systems, Limited | Device suitable for mixing medication |
US5226878A (en) * | 1992-01-10 | 1993-07-13 | Whitaker Designs, Inc. | Two-container system for mixing medicament with diluent including safety wand to protect against improper titration |
US20050241634A1 (en) * | 1996-04-19 | 2005-11-03 | Dieter Hochrainer | Two-chamber cartridge for propellant-free metering aerosols |
US7980243B2 (en) | 1996-04-19 | 2011-07-19 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | Two-chamber cartridge for propellant-free metering aerosols |
US7793655B2 (en) | 1996-04-19 | 2010-09-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-chamber cartridge for propellant-free metering aerosols |
US20080033391A1 (en) * | 1996-04-19 | 2008-02-07 | Boehringer Ingelheim Kg | Two-Chamber Cartridge For Propellant-Free Metering Aerosols |
US7213593B2 (en) | 1996-04-19 | 2007-05-08 | Boehringer Ingelheim Kg | Two-chamber cartridge for propellant-free metering aerosols |
US6065828A (en) * | 1997-02-26 | 2000-05-23 | Hewlett-Packard Company | Selectable mixing of inkjet ink components |
WO1998056438A1 (en) * | 1997-06-10 | 1998-12-17 | Astra Pharmaceuticals Pty. Ltd. | Prefilled container |
US7040311B2 (en) | 1998-10-17 | 2006-05-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Closure-cap and container as a two-chamber cartridge for nebulizers for producing aerosols and active substance formulations, suitable for storage |
US20060196500A1 (en) * | 1998-10-17 | 2006-09-07 | Boehringer Ingelheim Pharma Kmbh & Co. Kg | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage |
US6986346B2 (en) * | 1998-10-17 | 2006-01-17 | Boehringer Ingelheim Pharma Kg | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage |
US6481435B2 (en) * | 1998-10-17 | 2002-11-19 | Boehringer Ingelheim Pharma Kg | Closure-cap and container as a two-chamber cartridge for nebulizers for producing aerosols and active substance formulations, suitable for storage |
US20030066524A1 (en) * | 1998-10-17 | 2003-04-10 | Boehringer Ingelheim Pharma Kg | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage |
US7232419B2 (en) | 2002-02-11 | 2007-06-19 | Baxter International Inc. | Enclosure with cam action snap release |
US7198611B2 (en) | 2002-02-11 | 2007-04-03 | Baxter International Inc. | Dialysis connector and cap having an integral disinfectant |
US20030181849A1 (en) * | 2002-02-11 | 2003-09-25 | Castellanos Rafael A. | Enclosure with cam action snap release |
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Also Published As
Publication number | Publication date |
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USRE29062E (en) | 1976-12-07 |
CA1001513A (en) | 1976-12-14 |
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