US3901219A - Blood collecting container and method - Google Patents

Blood collecting container and method Download PDF

Info

Publication number
US3901219A
US3901219A US491820A US49182074A US3901219A US 3901219 A US3901219 A US 3901219A US 491820 A US491820 A US 491820A US 49182074 A US49182074 A US 49182074A US 3901219 A US3901219 A US 3901219A
Authority
US
United States
Prior art keywords
container
blood
piston
closure
elastomeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US491820A
Inventor
Donald A Kay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Priority to US491820A priority Critical patent/US3901219A/en
Application granted granted Critical
Publication of US3901219A publication Critical patent/US3901219A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes

Definitions

  • NO: 491,820 Disclosed herein is an apparatus and method for obtaming accurate, consistent filling of an evacuated blood collecting tube under varying atmospheric pres- [52] US. Cl. 128/2 F; l28/DIG. 5 ure conditions,
  • the apparatus comprises a gaspr00f ⁇ 51] Int. Cl.
  • A61B 5/14 t b l r container having one open end and one closed Field Of sealchm 128/2 DICI- 214 end; a gas-proof, elastomeric self-sealing closure to seal the open' end; an elastomeric barrier-piston which 425-4 R forms a sliding-seal with the interior side walls of the container; and an indentation for preventing the pis- [56] R f r C t d ton from traversing the entire length of the container.
  • the method of the invention comprises employing the 3 508,653 4/1970 Coleman 128/2 F apparatus of the invention in the colleclio" of 3645253 2/1972 Govcrdc ct alm 128/2 F malian blood.
  • the apparatus and method of the inven- 3,687,296 8/1972 Spinosa 128/2 F i n is p rti larly seful for the collection of blood 3,753,432 8/1973 Guerra 128/2 F with a simultaneous admixture of a chemical additive.
  • the invention concerns a method and apparatus for the collection of mammalian blood specimens and more particularly concerns an apparatus and method for the collection of an accurate measure of blood specimen from a mammal.
  • the apparatus of my invention is a unitary, simply constructed and economical unit which may be disposed of after a single use.
  • the apparatus and method of my invention are readily employed by para-medical personnel having a minimum amount of training in accurate blood collection and analysis techniques.
  • the invention comprises an apparatus for the collection of an accurate measure of blood which comprises: a gas-proof tubular container having one open end and one closed end; a gas-proof, elastomeric, self-sealing closure to seal said open end; an elastomeric barrierpiston formed of an elastomeric material and which forms a sliding-seal with the interior side walls of said container; and means for preventing said piston from traversing the entire length of said container; provided that at least one of said closure and said piston has a recess in the surface thereof which is proximal to the other of said closure and said piston.
  • the invention also comprises the method of collecting an accurate measure of blood employing the apparatus of the invention.
  • FIG. 1 is a cross-sectional side elevation of an embodiment within the scope of the apparatus of the invention shown prior to its operation.
  • FIG. 2 is a cross-sectional side elevation of the embodiment seen in FIG. 1 but following its filling with blood.
  • FIG. 3 is a cross-sectional side elevation of the em bodiment of the invention as seen in FIG. 2 but following its centrifugation to separate the collected blood into its light liquid component and its heavy, substantially cellular component.
  • the apparatus of the invention may be fabricated from conventional materials.
  • the gasproof container may be formed of glass.
  • the gas-proof closures employed herein may be fabricated of any suitable elastomeric self-sealing materials.
  • the preferred material for forming gas-proof closures is butyl rubber.
  • FIG. 1 is a cross-sectional side elevation of an apparatus of the invention referred to generally by the symbol 10.
  • Apparatus 10 comprises a gas-proof tubular container member 12 having one end sealed with a gasproof, penetrable closure 14 and a second end 13 which is sealed.
  • Closure 14 is a member which may be termed a stopper which may be characterized by its cylindrical body portion 16 which is inserted under compression into the open end of container 12 so as to maintain container 12 in a sealed gas type engagement. Stopper 14 also has an enlarged head portion 18 to facilitate its insertion and removal.
  • Body portion 16 of closure 14 has an annular recess 20 therein which together with axial recess 22 in head portion 18 forms a thin penetrable zone 24 in closure member 14.
  • the thin penetrable zone 24 should have a minimum of at least 0.06 inches thickness when the elastomeric material of which stopper 14 is formed is butyl rubber. This minimum thickness assures that the apparatus 10 will maintain a vacuum for a period of at least 2 years.
  • a piston-barrier member 30 Nested beneath closure 14 is a piston-barrier member 30 which forms an interference-sliding fit with the interior walls 32 of container 12.
  • Piston-barrier 30 as shown in FIG. 1 has a central cylindrical body portion 34 and integral upper sealing ring 36 and lower sealing ring 38 which form a sliding seal with the interior wall 32 of container 12.
  • Within the central body portion 34 of piston-barrier member 30 there is an annular recess 35 which is provided as an alternate embodiment when it is desired to add chemicals 39 to the collected blood.
  • the chemical additive is stored within annular recess 35 prior to the collection of blood.
  • the volumetric area for annular recess 35 is sufficient to hold the chemical additive with a minimal amount of air space.
  • the amount of air space above the piston has a direct bearing on the accuracy of the filling of the tube. The more space above the piston 30 initially, the less accurate is the filling procedure. A small amount of space is required to allow the needle room to penetrate the stopper, but such space should be minimal.
  • the apparatus of the invention as shown in the embodiment of FIG. 1 may be assembled under conditions of a partial vacuum so that chamber 40 of container 12 will have a partial vacuum contained therein.
  • the vacuum employed is circa 26 millimeters of mercury.
  • the method of the invention is carried out by filling an evacuated apparatus of the invention 10 with blood, upon which analysis is desired.
  • FIG. 2 there is seen apparatus 10 which has been penetrated by cannula 35 through thin penetrable zone 24 of the closure 14.
  • the open end of cannula 37 terminates within recess 20.
  • Recess 20 should have a minimal volumetric capacity, i.e.; the minimum space required to allow the needle room to penetrate the stopper and receive an initial flow of blood.
  • the pressure above piston-barrier 30 is increased over the pressure found in evacuated chamber 40.
  • the pressure differential causes piston-barrier 30 to descend within container 12 while maintaining sealing engagement with the inner walls 32 of container 12.
  • Constriction 44 is a stop means positioned so that upper chamber 40A has a precise volumetric capacity as required for an accurate volumetric collection of blood.
  • the stop means may be a force fit plastic ring inserted in the container at the desired point. or a tubular sleeve of specified length inserted in the lower end of the container.
  • pistonbarrier 30 Upon striking stop means 44, pistonbarrier 30 is halted and when the pressure in upper chamber 40A equals the pressure of incoming blood, the filling of container 12 with blood terminates and cannula 37 may be withdrawn whereupon the thin penetrable self-sealing zone 24 seals the opening previously made by cannula 37.
  • the annular recess 35 contains a chemical additive such as heparin, sodium oxalate, potassium oxalate or the like then the incoming blood 5 automatically admixes therewith to result in an accurate volumetric collection of blood in admixture with a precise amount of chemical additive previously enclosed within recess '35. That portion of the container represented by chamber 408 will contain residual air not evacuated during assembly of the apparatus l0. Piston-barrier 30 forms a permanent seal between this residual air and the collected blood so that the collected blood is not exposed to atmospheric gases.
  • the apparatus may be centrifuged conventionally to effect a separation of the collected blood into its lighter liquid or plasma portion and its heavier substantially cellular portion.
  • F IG. 3 is a cross-sectional side elevation of a filled apparatus 10 shown following centrifugation wherein the blood has now been separated into its light liquid por tion 5A and its substantially cellular portion 53.
  • Apparatus for the collection of an accurate measure of blood which comprises:
  • a gas-proof tubular container having one open end and one closed end;
  • an elastomeric barrier-piston formed of an elastomeric material and which forms a sliding-seal with the interior side walls of said container;
  • said piston means for preventing said piston from traversing the entire length of said container; provided that at least one of said closure and said piston has a recess in the surface thereof which is proximal to the other of said closure and said piston, said recess providing only the minimum space required to allow the needle room to penetrate the stopper and receive an initial flow of blood; and
  • said apparatus having a partial vacuum in all chambers within said container.
  • a method of collecting an accurate measure of blood which comprises:
  • an elastomeric barrier-piston formed of an elastomeric material and which forms a sliding-seal with the interior side walls of said container;
  • At least one of said closure and said piston has a recess in the surface thereof which is proximal to the other of said closure and said piston, said recess providing only the minimum space required to allow the needle room to penetrate the stopper and receive an initial flow of blood; said apparatus having a partial vacuum in all chambers within said container; and

Abstract

Disclosed herein is an apparatus and method for obtaining accurate, consistent filling of an evacuated blood collecting tube under varying atmospheric pressure conditions. The apparatus comprises a gas-proof tubular container having one open end and one closed end; a gas-proof, elastomeric self-sealing closure to seal the open end; an elastomeric barrier-piston which forms a sliding-seal with the interior side walls of the container; and an indentation for preventing the piston from traversing the entire length of the container. The method of the invention comprises employing the apparatus of the invention in the collection of mammalian blood. The apparatus and method of the invention is particularly useful for the collection of blood with a simultaneous admixture of a chemical additive.

Description

United States 1 atent 11 1 1111 3,901,219 Kay 1451 Aug. 26, 1975 BLOOD COLLECTING CONTAINER AND METHOD Primary ExaminerRichard A. Gaudet Assistant Examiner-J. C. McGowan [75] lnvemor' Donald Sharon Mass' Attorney, Agent, or FirmKane, Dalsimer, Kane, [73] Assigneu; Becton, Dickinson and Company, Sullivan and Kurucz East Rutherford, NJ.
22 Filed: July 25, 1974 1 ABSTRACT [211 App]. NO: 491,820 Disclosed herein is an apparatus and method for obtaming accurate, consistent filling of an evacuated blood collecting tube under varying atmospheric pres- [52] US. Cl. 128/2 F; l28/DIG. 5 ure conditions, The apparatus comprises a gaspr00f {51] Int. Cl. A61B 5/14 t b l r container having one open end and one closed Field Of sealchm 128/2 DICI- 214 end; a gas-proof, elastomeric self-sealing closure to seal the open' end; an elastomeric barrier-piston which 425-4 R forms a sliding-seal with the interior side walls of the container; and an indentation for preventing the pis- [56] R f r C t d ton from traversing the entire length of the container. UNITED STATES PATENTS The method of the invention comprises employing the 3 508,653 4/1970 Coleman 128/2 F apparatus of the invention in the colleclio" of 3645253 2/1972 Govcrdc ct alm 128/2 F malian blood. The apparatus and method of the inven- 3,687,296 8/1972 Spinosa 128/2 F i n is p rti larly seful for the collection of blood 3,753,432 8/1973 Guerra 128/2 F with a simultaneous admixture of a chemical additive. 3,779,383 12/1973 Ayrcs 210/1310. 24 3,786,985 1/1974 Blaivas 210 1310. 24 4 Clams 3 Drawmg Flgures l5 i l l? BLOOD COLLECTING CONTAINER AND METHOD BACKGROUND OF THE INVENTION 1. Field of the Invention The invention concerns a method and apparatus for the collection of mammalian blood specimens and more particularly concerns an apparatus and method for the collection of an accurate measure of blood specimen from a mammal.
2. Brief Description of the Prior Art The art is replete with descriptions of method and apparatus for the collection of mammalian blood for the purpose of diagnostic determinations. One of the most convenient methods for the collection of mammalian blood is within an air evacuated collection tube such as that described in US. Pat. No. 2,460,641. At the present time, however, identically evacuated blood collection tubes will draw varying amounts of blood in different parts of the world and on different days in the same geographic locality. This is due to atmospheric pressure variations (which can be a result of weather conditions or altitude differences). The accurate filling of evacuated blood collection tubes is most critical in blood collection tubes which contain a chemical additive for admixture with the collected blood specimen. For example, when the evacuated tube contains an anticoagulant such as heparin. Too high or too low a blood to additive ratio may cause the blood sample to give inaccurate results in subsequent blood chemistry testing. This could ultimately lead to an error in analysis.
Prior hereto an apparatus and means for automatically collecting a measured amount of blood into an evacuated blood collection tube has not been available. The apparatus and method of my invention fills this long awaited need.
By the method and apparatus of my invention, it is now possible to collect almost automatically, an accurate measure of blood for clinical analysis. The collected blood may then be separated into its liquid and substantially cellular portions without transfer to a separate container for centrifuging. The apparatus of my invention is a unitary, simply constructed and economical unit which may be disposed of after a single use. The apparatus and method of my invention are readily employed by para-medical personnel having a minimum amount of training in accurate blood collection and analysis techniques.
SUMMARY OF THE INVENTION The invention comprises an apparatus for the collection of an accurate measure of blood which comprises: a gas-proof tubular container having one open end and one closed end; a gas-proof, elastomeric, self-sealing closure to seal said open end; an elastomeric barrierpiston formed of an elastomeric material and which forms a sliding-seal with the interior side walls of said container; and means for preventing said piston from traversing the entire length of said container; provided that at least one of said closure and said piston has a recess in the surface thereof which is proximal to the other of said closure and said piston. The invention also comprises the method of collecting an accurate measure of blood employing the apparatus of the invention.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a cross-sectional side elevation of an embodiment within the scope of the apparatus of the invention shown prior to its operation.
FIG. 2 is a cross-sectional side elevation of the embodiment seen in FIG. 1 but following its filling with blood.
FIG. 3 is a cross-sectional side elevation of the em bodiment of the invention as seen in FIG. 2 but following its centrifugation to separate the collected blood into its light liquid component and its heavy, substantially cellular component.
DETAILED DESCRIPTION OF THE INVENTION The apparatus of the invention may be fabricated from conventional materials. Illustratively, the gasproof container may be formed of glass. The gas-proof closures employed herein may be fabricated of any suitable elastomeric self-sealing materials. The preferred material for forming gas-proof closures is butyl rubber. The methods and techniques of assembling the apparatus of the invention will be obvious to those skilled in the art.
The apparatus of the invention and the method of the invention will now be further described and exemplified by reference to the various specific embodiments set forth in the drawings.
FIG. 1 is a cross-sectional side elevation of an apparatus of the invention referred to generally by the symbol 10. Apparatus 10 comprises a gas-proof tubular container member 12 having one end sealed with a gasproof, penetrable closure 14 and a second end 13 which is sealed. Closure 14 is a member which may be termed a stopper which may be characterized by its cylindrical body portion 16 which is inserted under compression into the open end of container 12 so as to maintain container 12 in a sealed gas type engagement. Stopper 14 also has an enlarged head portion 18 to facilitate its insertion and removal. Body portion 16 of closure 14 has an annular recess 20 therein which together with axial recess 22 in head portion 18 forms a thin penetrable zone 24 in closure member 14. The thin penetrable zone 24 should have a minimum of at least 0.06 inches thickness when the elastomeric material of which stopper 14 is formed is butyl rubber. This minimum thickness assures that the apparatus 10 will maintain a vacuum for a period of at least 2 years. Nested beneath closure 14 is a piston-barrier member 30 which forms an interference-sliding fit with the interior walls 32 of container 12. Piston-barrier 30 as shown in FIG. 1 has a central cylindrical body portion 34 and integral upper sealing ring 36 and lower sealing ring 38 which form a sliding seal with the interior wall 32 of container 12. Within the central body portion 34 of piston-barrier member 30 there is an annular recess 35 which is provided as an alternate embodiment when it is desired to add chemicals 39 to the collected blood. The chemical additive is stored within annular recess 35 prior to the collection of blood. The volumetric area for annular recess 35 is sufficient to hold the chemical additive with a minimal amount of air space. The amount of air space above the piston has a direct bearing on the accuracy of the filling of the tube. The more space above the piston 30 initially, the less accurate is the filling procedure. A small amount of space is required to allow the needle room to penetrate the stopper, but such space should be minimal.
The apparatus of the invention as shown in the embodiment of FIG. 1 may be assembled under conditions of a partial vacuum so that chamber 40 of container 12 will have a partial vacuum contained therein. In practice, the vacuum employed is circa 26 millimeters of mercury.
The method of the invention is carried out by filling an evacuated apparatus of the invention 10 with blood, upon which analysis is desired. Referring now to FIG. 2 there is seen apparatus 10 which has been penetrated by cannula 35 through thin penetrable zone 24 of the closure 14. The open end of cannula 37 terminates within recess 20. Recess 20 should have a minimal volumetric capacity, i.e.; the minimum space required to allow the needle room to penetrate the stopper and receive an initial flow of blood. As blood enters the axial recess 20, the pressure above piston-barrier 30 is increased over the pressure found in evacuated chamber 40. The pressure differential causes piston-barrier 30 to descend within container 12 while maintaining sealing engagement with the inner walls 32 of container 12. Piston-barrier 30 will descend within container 12 until it is stopped by constriction 44 which is integrally molded within the walls of container 12. Constriction 44 is a stop means positioned so that upper chamber 40A has a precise volumetric capacity as required for an accurate volumetric collection of blood. Alternatively, the stop means may be a force fit plastic ring inserted in the container at the desired point. or a tubular sleeve of specified length inserted in the lower end of the container. Upon striking stop means 44, pistonbarrier 30 is halted and when the pressure in upper chamber 40A equals the pressure of incoming blood, the filling of container 12 with blood terminates and cannula 37 may be withdrawn whereupon the thin penetrable self-sealing zone 24 seals the opening previously made by cannula 37. When the annular recess 35 contains a chemical additive such as heparin, sodium oxalate, potassium oxalate or the like then the incoming blood 5 automatically admixes therewith to result in an accurate volumetric collection of blood in admixture with a precise amount of chemical additive previously enclosed within recess '35. That portion of the container represented by chamber 408 will contain residual air not evacuated during assembly of the apparatus l0. Piston-barrier 30 forms a permanent seal between this residual air and the collected blood so that the collected blood is not exposed to atmospheric gases.
Following collection of blood 5, the apparatus may be centrifuged conventionally to effect a separation of the collected blood into its lighter liquid or plasma portion and its heavier substantially cellular portion.
F IG. 3 is a cross-sectional side elevation of a filled apparatus 10 shown following centrifugation wherein the blood has now been separated into its light liquid por tion 5A and its substantially cellular portion 53. To remove the light liquid portion for chemical analysis, one may remove closure 14 and remove by decantation or pipette the light liquid portion for chemical analysis.
What is claimed:
1. Apparatus for the collection of an accurate measure of blood which comprises:
a gas-proof tubular container having one open end and one closed end;
a gas-proof, elastomeric, self-sealing closure sealing said open end;
an elastomeric barrier-piston formed of an elastomeric material and which forms a sliding-seal with the interior side walls of said container;
means for preventing said piston from traversing the entire length of said container; provided that at least one of said closure and said piston has a recess in the surface thereof which is proximal to the other of said closure and said piston, said recess providing only the minimum space required to allow the needle room to penetrate the stopper and receive an initial flow of blood; and
said apparatus having a partial vacuum in all chambers within said container.
2. Apparatus according to claim 1 wherein said selfsealing closure has a thin zone which is penetrable by a cannula.
3. Apparatus according to claim 1 wherein said piston has integral sealing rings in the side walls thereof for forming a seal with the interior walls of said container.
4. A method of collecting an accurate measure of blood which comprises:
A. providing an air-evacuated tubular container having one open end and one closed end;
a gas-proof elastomeric self-sealing closure sealing said open end;
an elastomeric barrier-piston formed of an elastomeric material and which forms a sliding-seal with the interior side walls of said container;
means for preventing said piston from traversing the entire length of said container;
provided that at least one of said closure and said piston has a recess in the surface thereof which is proximal to the other of said closure and said piston, said recess providing only the minimum space required to allow the needle room to penetrate the stopper and receive an initial flow of blood; said apparatus having a partial vacuum in all chambers within said container; and
B. filling said container by inserting a cannula into said recess, said cannula being attached to a source of blood.

Claims (4)

1. Apparatus for the collection of an accurate measure of blood which comprises: a gas-proof tubular container having one open end and one closed end; a gas-proof, elastomeric, self-sealing closure sealing said open end; an elastomeric barrier-piston formed of an elastomeric material and which forms a sliding-seal with the interior side walls of said container; means for preventing said piston from traversing the entire length of said container; provided that at least one of said closure and said piston has a recess in the surface thereof which is proximal to the other of said closure and said piston, said recess providing only the minimum space required to allow the needle room to penetrate the stopper and receive an initial flow of blood; and said apparatus having a partial vacuum in all chambErs within said container.
2. Apparatus according to claim 1 wherein said self-sealing closure has a thin zone which is penetrable by a cannula.
3. Apparatus according to claim 1 wherein said piston has integral sealing rings in the side walls thereof for forming a seal with the interior walls of said container.
4. A method of collecting an accurate measure of blood which comprises: A. providing an air-evacuated tubular container having one open end and one closed end; a gas-proof elastomeric self-sealing closure sealing said open end; an elastomeric barrier-piston formed of an elastomeric material and which forms a sliding-seal with the interior side walls of said container; means for preventing said piston from traversing the entire length of said container; provided that at least one of said closure and said piston has a recess in the surface thereof which is proximal to the other of said closure and said piston, said recess providing only the minimum space required to allow the needle room to penetrate the stopper and receive an initial flow of blood; said apparatus having a partial vacuum in all chambers within said container; and B. filling said container by inserting a cannula into said recess, said cannula being attached to a source of blood.
US491820A 1974-07-25 1974-07-25 Blood collecting container and method Expired - Lifetime US3901219A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US491820A US3901219A (en) 1974-07-25 1974-07-25 Blood collecting container and method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US491820A US3901219A (en) 1974-07-25 1974-07-25 Blood collecting container and method

Publications (1)

Publication Number Publication Date
US3901219A true US3901219A (en) 1975-08-26

Family

ID=23953813

Family Applications (1)

Application Number Title Priority Date Filing Date
US491820A Expired - Lifetime US3901219A (en) 1974-07-25 1974-07-25 Blood collecting container and method

Country Status (1)

Country Link
US (1) US3901219A (en)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3986962A (en) * 1975-07-10 1976-10-19 Becton, Dickinson And Company Novel assembly for separating blood
US4020831A (en) * 1975-12-04 1977-05-03 Technicon Instruments Corporation Blood collecting syringe
US4091802A (en) * 1976-02-17 1978-05-30 Eastman Kodak Company Vented liquid collection device
US4147628A (en) * 1978-01-23 1979-04-03 Becton, Dickinson And Company Blood partitioning method
US4212307A (en) * 1978-01-12 1980-07-15 Concord Laboratories, Inc. Blood sampling syringe
US4215702A (en) * 1978-01-12 1980-08-05 Patrick Ayer Arterial blood extraction device
US4216782A (en) * 1977-02-15 1980-08-12 Sarstedt W Device for the extraction of blood
DE3012056A1 (en) * 1979-03-28 1980-10-09 Neuhaus Pharmaglas Bacteraemia detection appts. - comprising a blood sampling and a blood culture system for separate incubation of liq. and solid nutrient medium
EP0017127A2 (en) * 1979-03-23 1980-10-15 Terumo Corporation A method for separating blood and a barrier device therefor
US4245654A (en) * 1977-03-22 1981-01-20 Concord Laboratories, Inc. Blood sampling syringe
US4279863A (en) * 1979-09-12 1981-07-21 Sherwood Medical Industries, Inc. Reagent separator for a blood collection tube
US4361155A (en) * 1980-10-29 1982-11-30 Anastasio Frank W Blood sampling unit
US4588556A (en) * 1983-12-05 1986-05-13 Walter Sarstedt Kunststoff-Spritzgusswerk Arrangement for placing a separating gel between two phases located in a sample tube
WO1987001924A1 (en) * 1985-09-29 1987-04-09 Al Sioufi Habib Method and device for disinfecting biological fluids and container for same
US4818386A (en) * 1987-10-08 1989-04-04 Becton, Dickinson And Company Device for separating the components of a liquid sample having higher and lower specific gravities
US4936314A (en) * 1982-10-08 1990-06-26 Terumo Kabushiki Kaisha Method of evacuating and preserving a blood collecting device
DE4217104A1 (en) * 1992-05-22 1993-11-25 Salama Magdy Reservoir or reservoir system - for inactivation, inhibition and/or elimination of pathogens
US5342753A (en) * 1989-06-15 1994-08-30 Smith Jr William I Blood collecting tube with blood factor antibodies as anticoagulant
FR2722090A1 (en) * 1994-06-06 1996-01-12 Becton Dickinson Co BLOOD TAKING KIT
EP0728522A2 (en) * 1995-02-21 1996-08-28 Becton, Dickinson and Company Blood collection assembly having additive dispensing means and method for sample collection using same
US5593639A (en) * 1994-05-26 1997-01-14 Japan Synthetic Rubber Co., Ltd. Blood-sampling vessel
US6001087A (en) * 1996-09-30 1999-12-14 Becton Dickinson And Company Collection assembly with a reservoir
US6238578B1 (en) 1996-12-09 2001-05-29 Sherwood Services Ag Method for dispensing separator gel in a blood collection tube
US20020156439A1 (en) * 1997-09-12 2002-10-24 Michael J. Iskra Collection container assembly
US20040115689A1 (en) * 2000-11-08 2004-06-17 Augello Frank A. Method and device for collecting and stabilizing a biological sample
US20100160135A1 (en) * 2008-07-21 2010-06-24 Becton, Dickinson And Company Density Phase Separation Device
US20100288694A1 (en) * 2009-05-15 2010-11-18 Becton, Dickinson And Company Density Phase Separation Device
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US20150173660A1 (en) * 2011-10-20 2015-06-25 Becton, Dickinson And Company Blood Collection Assembly And Method for Use Thereof
US20150231631A1 (en) * 2012-11-30 2015-08-20 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US20160157767A1 (en) * 2008-03-05 2016-06-09 Becton, Dickinson And Company Capillary Action Collection Device and Container Assembly
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3508653A (en) * 1967-11-17 1970-04-28 Charles M Coleman Method and apparatus for fluid handling and separation
US3645253A (en) * 1968-11-12 1972-02-29 Organon Instrument for the withdrawal of body fluids
US3687296A (en) * 1971-03-26 1972-08-29 Ewi Research & Dev Corp Fluid separator
US3753432A (en) * 1971-03-10 1973-08-21 L Guerra Hypodermic syringe for blood tests
US3779383A (en) * 1972-04-25 1973-12-18 Becton Dickinson Co Sealed assembly for separation of blood components and method
US3786985A (en) * 1973-01-05 1974-01-22 Hoffmann La Roche Blood collection container

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3508653A (en) * 1967-11-17 1970-04-28 Charles M Coleman Method and apparatus for fluid handling and separation
US3645253A (en) * 1968-11-12 1972-02-29 Organon Instrument for the withdrawal of body fluids
US3753432A (en) * 1971-03-10 1973-08-21 L Guerra Hypodermic syringe for blood tests
US3687296A (en) * 1971-03-26 1972-08-29 Ewi Research & Dev Corp Fluid separator
US3779383A (en) * 1972-04-25 1973-12-18 Becton Dickinson Co Sealed assembly for separation of blood components and method
US3786985A (en) * 1973-01-05 1974-01-22 Hoffmann La Roche Blood collection container

Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3986962A (en) * 1975-07-10 1976-10-19 Becton, Dickinson And Company Novel assembly for separating blood
US4020831A (en) * 1975-12-04 1977-05-03 Technicon Instruments Corporation Blood collecting syringe
US4091802A (en) * 1976-02-17 1978-05-30 Eastman Kodak Company Vented liquid collection device
US4216782A (en) * 1977-02-15 1980-08-12 Sarstedt W Device for the extraction of blood
US4245654A (en) * 1977-03-22 1981-01-20 Concord Laboratories, Inc. Blood sampling syringe
US4212307A (en) * 1978-01-12 1980-07-15 Concord Laboratories, Inc. Blood sampling syringe
US4215702A (en) * 1978-01-12 1980-08-05 Patrick Ayer Arterial blood extraction device
US4147628A (en) * 1978-01-23 1979-04-03 Becton, Dickinson And Company Blood partitioning method
EP0017127A2 (en) * 1979-03-23 1980-10-15 Terumo Corporation A method for separating blood and a barrier device therefor
EP0017127A3 (en) * 1979-03-23 1980-12-10 Terumo Corporation A method for separating blood and a barrier device therefor
DE3012056A1 (en) * 1979-03-28 1980-10-09 Neuhaus Pharmaglas Bacteraemia detection appts. - comprising a blood sampling and a blood culture system for separate incubation of liq. and solid nutrient medium
US4279863A (en) * 1979-09-12 1981-07-21 Sherwood Medical Industries, Inc. Reagent separator for a blood collection tube
US4361155A (en) * 1980-10-29 1982-11-30 Anastasio Frank W Blood sampling unit
US4936314A (en) * 1982-10-08 1990-06-26 Terumo Kabushiki Kaisha Method of evacuating and preserving a blood collecting device
US4588556A (en) * 1983-12-05 1986-05-13 Walter Sarstedt Kunststoff-Spritzgusswerk Arrangement for placing a separating gel between two phases located in a sample tube
WO1987001924A1 (en) * 1985-09-29 1987-04-09 Al Sioufi Habib Method and device for disinfecting biological fluids and container for same
US4675159A (en) * 1985-09-29 1987-06-23 Al Sioufi Habib Method and device for disinfecting biological fluids and container for same
US4818386A (en) * 1987-10-08 1989-04-04 Becton, Dickinson And Company Device for separating the components of a liquid sample having higher and lower specific gravities
US5342753A (en) * 1989-06-15 1994-08-30 Smith Jr William I Blood collecting tube with blood factor antibodies as anticoagulant
DE4217104A1 (en) * 1992-05-22 1993-11-25 Salama Magdy Reservoir or reservoir system - for inactivation, inhibition and/or elimination of pathogens
US5593639A (en) * 1994-05-26 1997-01-14 Japan Synthetic Rubber Co., Ltd. Blood-sampling vessel
US5511558A (en) * 1994-06-06 1996-04-30 Becton, Dickinson And Company Blood collection assembly having additive dispensing means and method for sample collection using same
DE19519886C2 (en) * 1994-06-06 1998-11-05 Becton Dickinson Co Blood collection device and method for preparing a blood sample
FR2722090A1 (en) * 1994-06-06 1996-01-12 Becton Dickinson Co BLOOD TAKING KIT
EP0728522A2 (en) * 1995-02-21 1996-08-28 Becton, Dickinson and Company Blood collection assembly having additive dispensing means and method for sample collection using same
US5738670A (en) * 1995-02-21 1998-04-14 Becton, Dickinson And Company Blood collection assembly having additive dispensing means
EP0728522A3 (en) * 1995-02-21 1998-05-27 Becton, Dickinson and Company Blood collection assembly having additive dispensing means and method for sample collection using same
US20010007315A1 (en) * 1995-12-12 2001-07-12 Fiehler William R. Method and apparatus for dispensing separator gel in a blood collection tube
US6001087A (en) * 1996-09-30 1999-12-14 Becton Dickinson And Company Collection assembly with a reservoir
US6238578B1 (en) 1996-12-09 2001-05-29 Sherwood Services Ag Method for dispensing separator gel in a blood collection tube
US20020156439A1 (en) * 1997-09-12 2002-10-24 Michael J. Iskra Collection container assembly
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US20040115689A1 (en) * 2000-11-08 2004-06-17 Augello Frank A. Method and device for collecting and stabilizing a biological sample
US11944434B2 (en) 2008-03-05 2024-04-02 Becton, Dickinson And Company Capillary action collection device and container assembly
US10499840B2 (en) * 2008-03-05 2019-12-10 Becton, Dickinson And Company Capillary action collection device and container assembly
US20160157767A1 (en) * 2008-03-05 2016-06-09 Becton, Dickinson And Company Capillary Action Collection Device and Container Assembly
US8747781B2 (en) 2008-07-21 2014-06-10 Becton, Dickinson And Company Density phase separation device
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US20100160135A1 (en) * 2008-07-21 2010-06-24 Becton, Dickinson And Company Density Phase Separation Device
US10350591B2 (en) 2008-07-21 2019-07-16 Becton, Dickinson And Company Density phase separation device
US9933344B2 (en) 2008-07-21 2018-04-03 Becton, Dickinson And Company Density phase separation device
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US9339741B2 (en) 2008-07-21 2016-05-17 Becton, Dickinson And Company Density phase separation device
US9714890B2 (en) 2008-07-21 2017-07-25 Becton, Dickinson And Company Density phase separation device
US9700886B2 (en) 2008-07-21 2017-07-11 Becton, Dickinson And Company Density phase separation device
US9452427B2 (en) 2008-07-21 2016-09-27 Becton, Dickinson And Company Density phase separation device
US9364828B2 (en) 2009-05-15 2016-06-14 Becton, Dickinson And Company Density phase separation device
US10343157B2 (en) 2009-05-15 2019-07-09 Becton, Dickinson And Company Density phase separation device
US11786895B2 (en) 2009-05-15 2023-10-17 Becton, Dickinson And Company Density phase separation device
US8998000B2 (en) 2009-05-15 2015-04-07 Becton, Dickinson And Company Density phase separation device
US8794452B2 (en) 2009-05-15 2014-08-05 Becton, Dickinson And Company Density phase separation device
US9731290B2 (en) 2009-05-15 2017-08-15 Becton, Dickinson And Company Density phase separation device
US9802189B2 (en) 2009-05-15 2017-10-31 Becton, Dickinson And Company Density phase separation device
US9919307B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US9919308B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US9919309B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US11351535B2 (en) 2009-05-15 2022-06-07 Becton, Dickinson And Company Density phase separation device
US10807088B2 (en) 2009-05-15 2020-10-20 Becton, Dickinson And Company Density phase separation device
US9079123B2 (en) 2009-05-15 2015-07-14 Becton, Dickinson And Company Density phase separation device
US10376879B2 (en) 2009-05-15 2019-08-13 Becton, Dickinson And Company Density phase separation device
US10413898B2 (en) 2009-05-15 2019-09-17 Becton, Dickinson And Company Density phase separation device
US20100288694A1 (en) * 2009-05-15 2010-11-18 Becton, Dickinson And Company Density Phase Separation Device
US10456782B2 (en) 2009-05-15 2019-10-29 Becton, Dickinson And Company Density phase separation device
US10426391B2 (en) * 2011-10-20 2019-10-01 Becton, Dickinson And Company Blood collection cartridge, blood collection system, and blood collection method for use thereof
US20150173660A1 (en) * 2011-10-20 2015-06-25 Becton, Dickinson And Company Blood Collection Assembly And Method for Use Thereof
US9533303B2 (en) * 2012-11-30 2017-01-03 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US20150231631A1 (en) * 2012-11-30 2015-08-20 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid

Similar Documents

Publication Publication Date Title
US3901219A (en) Blood collecting container and method
RU2095024C1 (en) Blood sampling device intended for examination when centrifuging of this sample
EP0493838B1 (en) Constituent layer harvesting from a centrifuged sample in a tube
US3837376A (en) Blood serum collection tube and method
US4152269A (en) Collection and separation device
US5269317A (en) Intravenous blood sampling apparatus
US3930492A (en) Air-noncontact type blood sampling assembly
US3508653A (en) Method and apparatus for fluid handling and separation
US3957653A (en) Apparatus for collection, separation and isolation of blood
US3586064A (en) Blood serum collection tube and method of collection
US4134300A (en) Apparatus for evacuating and then collecting medium samples in containers sealed by a resilient stopper at substantially atmospheric pressure
US3901402A (en) Stopper-piston
US3706305A (en) Combination blood sampling vacuum syringe centrifuge container and specimen cup
US4154229A (en) Blood collection system with venipuncture indicator
US4022576A (en) Method and apparatus for preparation of liquids containing suspended material for examination
US3835835A (en) Two compartment locking sampling syringe
US8158062B2 (en) Disposable fluid sample collection device
US4703762A (en) Blood sampling device for obtaining dual samples of venous blood
US4037464A (en) Device for transferring blood or a similar fluid to a pipette
US3887464A (en) Serum/plasma separator with centrifugal valve seal
US4296759A (en) Blood collection device and method with anti-backflow means
EP0047176B1 (en) Device suitable for sampling blood
US3976579A (en) Novel assembly
JPH0670627B2 (en) Liquid sample component separation device and barrier assembly thereof
US4295974A (en) Blood sample collection and phase separation device